V.-M. Leppänen, A. E. Prota, M. Jeltsch, A. Anisimov, N. Kalkkinen, T. Strandin, H. Lankinen, A. Goldman, K. Ballmer-Hofer, K. Alitalo: Structural determinants of growth factor binding and specificity by VEGF receptor 2. In: Proceedings of the National Academy of Sciences. Band107, Nr.6, 2010, S.2425–2430, doi:10.1073/pnas.0914318107.
S. J. Oh, M. M. Jeltsch, R. Birkenhäger, J. E. McCarthy, H. A. Weich, B. Christ, K. Alitalo, J. Wilting: VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. In: Developmental Biology. Band188, Nr.1, 1997, S.96–109, doi:10.1006/dbio.1997.863.
M. Jeltsch, A. Kaipainen, V. Joukov, X. Meng, M. Lakso, H. Rauvala, M. Swartz, D. Fukumura, R. K. Jain, K. Alitalo: Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. In: Science. Band276, Nr.5317, 1997, S.1423–1425, doi:10.1126/science.276.5317.1423.
V. Joukov, T. Sorsa, V. Kumar, M. Jeltsch, L. Claesson-Welsh, Y. Cao, O. Saksela, N. Kalkkinen, K. Alitalo: Proteolytic processing regulates receptor specificity and activity of VEGF-C. In: The EMBO Journal. Band16, Nr.13, 1997, S.3898–3911, doi:10.1093/emboj/16.13.3898.
T. Tammela, G. Zarkada, E. Wallgard, A. Murtomäki, S. Suchting, M. Wirzenius, M. Waltari, M. Hellström, T. Schomber, R. Peltonen, C. Freitas, A. Duarte, H. Isoniemi, P. Laakkonen, G. Christofori, S. Ylä-Herttuala, M. Shibuya, B. Pytowski, A. Eichmann, C. Betsholtz, K. Alitalo: Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. In: Nature. Band454, Nr.7204, 2008, S.656–660, doi:10.1038/nature07083.
B. Le Bras, M. J. Barallobre, J. Homman-Ludiye, A. Ny, S. Wyns, T. Tammela, P. Haiko, M. J. Karkkainen, L. Yuan, M. P. Muriel, E. Chatzopoulou, C. Bréant, B. Zalc, P. Carmeliet, K. Alitalo, A. Eichmann, J. L. Thomas: VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. In: Nature Neuroscience. Band9, Nr.3, 2006, S.340–348, doi:10.1038/nn1646.
A. Machnik, W. Neuhofer, J. Jantsch, A. Dahlmann, T. Tammela, K. Machura, J. K. Park, F. X. Beck, D. N. Müller, W. Derer, J. Goss, A. Ziomber, P. Dietsch, H. Wagner, N. van Rooijen, A. Kurtz, K. F. Hilgers, K. Alitalo, K. U. Eckardt, F. C. Luft, D. Kerjaschki, J. Titze: Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. In: Nature Medicine. Band15, Nr.5, 2009, S.545–552, doi:10.1038/nm.1960.
K. Paavonen, N. Horelli-Kuitunen, D. Chilov, E. Kukk, S. Pennanen, O. P. Kallioniemi, K. Pajusola, B. Olofsson, U. Eriksson, V. Joukov, A. Palotie, K. Alitalo: Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively. In: Circulation. Band93, Nr.6, 1996, S.1079–1082, doi:10.1161/01.CIR.93.6.1079.
G. Siegfried, A. Basak, J. A. Cromlish, S. Benjannet, J. Marcinkiewicz, M. Chrétien, N. G. Seidah, A. M. Khatib: The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. In: The Journal of Clinical Investigation. Band111, Nr.11, 2003, S.1723–1732, doi:10.1172/JCI17220.
M. Jeltsch, S. K. Jha, D. Tvorogov, A. Anisimov, V. M. Leppänen, T. Holopainen, R. Kivelä, S. Ortega, T. Kärpanen, K. Alitalo: CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. In: Circulation. Band129, Nr.19, 2014, S.1962–1971, doi:10.1161/CIRCULATIONAHA.113.002779.
B. K. McColl, M. E. Baldwin, S. Roufail, C. Freeman, R. L. Moritz, R. J. Simpson, K. Alitalo, S. A. Stacker, M. G. Achen: Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D. In: The Journal of Experimental Medicine. Band198, Nr.6, 2003, S.863–868, doi:10.1084/jem.20030361.
Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch: KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D. In: eLife. Band8, 17. Mai 2019, ISSN2050-084X, S.–44478, doi:10.7554/eLife.44478 (elifesciences.org [abgerufen am 18. Mai 2019]).
M. J. Karkkainen, P. Haiko, K. Sainio, J. Partanen, J. Taipale, T. V. Petrova, M. Jeltsch, D. G. Jackson, M. Talikka, H. Rauvala, C. Betsholtz, K. Alitalo: Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. In: Nature Immunology. Band5, Nr.1, 2004, S.74–80, doi:10.1038/ni1013.
M. E. Baldwin, M. M. Halford, S. Roufail, R. A. Williams, M. L. Hibbs, D. Grail, H. Kubo, S. A. Stacker, M. G. Achen: Vascular endothelial growth factor D is dispensable for development of the lymphatic system. In: Molecular and Cellular Biology. Band25, Nr.6, 2005, S.2441–2449, doi:10.1128/MCB.25.6.2441-2449.2005.
M. E. Baldwin, B. Catimel, E. C. Nice, S. Roufail, N. E. Hall, K. L. Stenvers, M. J. Karkkainen, K. Alitalo, S. A. Stacker, M. G. Achen: The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man. In: The Journal of Biological Chemistry. Band276, Nr.22, 2001, S.19166–19171, doi:10.1074/jbc.M100097200.
E. Balboa-Beltran, M. J. Fernández-Seara, A. Pérez-Muñuzuri, R. Lago, C. García-Magán, M. L. Couce, B. Sobrino, J. Amigo, A. Carracedo, F. Barros: A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease. In: Journal of Medical Genetics. Band51, Nr.7, 2014, S.–2013–102020, doi:10.1136/jmedgenet-2013-102020.
B. Enholm, T. Karpanen, M. Jeltsch, H. Kubo, F. Stenback, R. Prevo, D. G. Jackson, S. Yla-Herttuala, K. Alitalo: Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin. In: Circulation Research. Band88, Nr.6, 2001, S.623–629, doi:10.1161/01.RES.88.6.623.
K. M. Honkonen, M. T. Visuri, T. V. Tervala, P. J. Halonen, M. Koivisto, M. T. Lähteenvuo, K. K. Alitalo, S. Ylä-Herttuala, A. M. Saaristo: Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema. In: Annals of Surgery. Band257, Nr.5, 2013, S.961–967, doi:10.1097/SLA.0b013e31826ed043.
P. Brouillard, L. Boon, M. Vikkula: Genetics of lymphatic anomalies. In: The Journal of Clinical Investigation. Band124, Nr.3, 2014, S.898–904, doi:10.1172/JCI71614.
M. J. Karkkainen, A. Saaristo, L. Jussila, K. A. Karila, E. C. Lawrence, K. Pajusola, H. Bueler, A. Eichmann, R. Kauppinen, M. I. Kettunen, S. Yla-Herttuala, D. N. Finegold, R. E. Ferrell, K. Alitalo: A model for gene therapy of human hereditary lymphedema. In: Proceedings of the National Academy of Sciences. Band98, Nr.22, 2001, S.12677–12682, doi:10.1073/pnas.221449198.
S. K. Jha, K. Rauniyar, T. Karpanen, V. M. Leppänen, P. Brouillard, M. Vikkula, K. Alitalo, M. Jeltsch: Efficient Activation of the Lymphangiogenic Growth Factor VEGF-C Requires the C-Terminal Domain of VEGF-C and the N-Terminal Domain of CCBE1. In: Scientific Reports. Band7, Nr.1, 2017, S.4916, doi:10.1038/s41598-017-04982-1.
D. Tvorogov, A. Anisimov, W. Zheng, V. M. Leppänen, T. Tammela, S. Laurinavicius, W. Holnthoner, H. Heloterä, T. Holopainen, M. Jeltsch, N. Kalkkinen, H. Lankinen, P. M. Ojala, K. Alitalo: Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. In: Cancer Cell. Band18, Nr.6, 2010, S.630–640, doi:10.1016/j.ccr.2010.11.001.
S. J. Mandriota, L. Jussila, M. Jeltsch, A. Compagni, D. Baetens, R. Prevo, S. Banerji, J. Huarte, R. Montesano, D. G. Jackson, L. Orci, K. Alitalo, G. Christofori, M. S. Pepper: Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. In: The EMBO Journal. Band20, Nr.4, 2001, S.672–682, doi:10.1093/emboj/20.4.672.
M. Tarsitano, S. De Falco, V. Colonna, J. D. McGhee, M. G. Persico: The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis. In: FASEB Journal. Band20, Nr.2, 2006, S.227–233, doi:10.1096/fj.05-4147com.
T. I. Heino, T. Kärpänen, G. Wahlström, M. Pulkkinen, U. Eriksson, K. Alitalo, C. Roos: The Drosophila VEGF receptor homolog is expressed in hemocytes. In: Mechanisms of Development. Band109, Nr.1, 2001, S.69–77, doi:10.1016/S0925-4773(01)00510-X.
K. Seipel, M. Eberhardt, P. Müller, E. Pescia, N. Yanze, V. Schmid: Homologs of vascular endothelial growth factor and receptor, VEGF and VEGFR, in the jellyfish Podocoryne carnea. In: Developmental Dynamics. Band231, Nr.2, 2004, S.303–312, doi:10.1002/dvdy.20139.
elifesciences.org
Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch: KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D. In: eLife. Band8, 17. Mai 2019, ISSN2050-084X, S.–44478, doi:10.7554/eLife.44478 (elifesciences.org [abgerufen am 18. Mai 2019]).
herantis.com
Herantis Pharma: Lymfactin® for lymphedema. 2014 (herantis.com).
zdb-katalog.de
Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch: KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D. In: eLife. Band8, 17. Mai 2019, ISSN2050-084X, S.–44478, doi:10.7554/eLife.44478 (elifesciences.org [abgerufen am 18. Mai 2019]).