5-HT2C receptor (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "5-HT2C receptor" in English language version.

refsWebsite

Global rank English rank

72nih.gov

4^th place

51doi.org

2^nd place

11semanticscholar.org

11^th place

8^th place

5harvard.edu

18^th place

17^th place

1ensembl.org

1,626^th place

1,007^th place

1unc.edu

1,538^th place

1,042^nd place

1acs.org

1,248^th place

1,104^th place

1worldcat.org

5^th place

acs.org (Global: 1,248^th place; English: 1,104^th place)

pubs.acs.org

Adhikari AS, Yadav A, Pandit S, Kumar S, Pandey VK, Maurya AK, et al. (26 November 2025). "Synthesis and Evaluation of Novel Aza-Aromatics as Dual 5-HT2A and 5-HT2C Receptor Agonists". ACS Medicinal Chemistry Letters. doi:10.1021/acsmedchemlett.5c00505. ISSN 1948-5875. Retrieved 29 November 2025.

doi.org (Global: 2^nd place; English: 2^nd place)

Stam NJ, Vanderheyden P, van Alebeek C, Klomp J, de Boer T, van Delft AM, et al. (November 1994). "Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor". European Journal of Pharmacology. 269 (3): 339–348. doi:10.1016/0922-4106(94)90042-6. PMID 7895773.
Herrick-Davis K, Grinde E, Lindsley T, Cowan A, Mazurkiewicz JE (July 2012). "Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers". The Journal of Biological Chemistry. 287 (28): 23604–23614. doi:10.1074/jbc.M112.350249. PMC 3390635. PMID 22593582.
Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, et al. (February 2018). "5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology". Cell. 172 (4): 719–730.e14. doi:10.1016/j.cell.2018.01.001. PMC 6309861. PMID 29398112.
Abramowski D, Rigo M, Duc D, Hoyer D, Staufenbiel M (December 1995). "Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera". Neuropharmacology. 34 (12): 1635–1645. doi:10.1016/0028-3908(95)00138-7. PMID 8788961. S2CID 45542707.
Hoffman BJ, Mezey E (April 1989). "Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain". FEBS Letters. 247 (2): 453–462. Bibcode:1989FEBSL.247..453H. doi:10.1016/0014-5793(89)81390-0. PMID 2714444. S2CID 23825490.
Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA (March 2005). "Modulation of dopamine release by striatal 5-HT2C receptors". Synapse. 55 (4): 242–251. doi:10.1002/syn.20109. PMID 15668911. S2CID 11405860.
Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (July 2007). "Serotonin 5-HT(2C) receptors regulate anxiety-like behavior". Genes, Brain, and Behavior. 6 (5): 491–496. doi:10.1111/j.1601-183X.2007.00316.x. PMID 17451451.
Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, et al. (May 2001). "RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy". Neuropsychopharmacology. 24 (5): 478–491. doi:10.1016/S0893-133X(00)00223-2. PMID 11282248.
Guaiana G, Gupta S, Chiodo D, Davies SJ, Haederle K, Koesters M (December 2013). "Agomelatine versus other antidepressive agents for major depression". The Cochrane Database of Systematic Reviews. 2013 (12) CD008851. doi:10.1002/14651858.CD008851.pub2. PMC 11289707. PMID 24343836.
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018). "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis". Lancet. 391 (10128): 1357–1366. doi:10.1016/S0140-6736(17)32802-7. PMC 5889788. PMID 29477251.
Ni YG, Miledi R (March 1997). "Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac)". Proceedings of the National Academy of Sciences of the United States of America. 94 (5): 2036–2040. Bibcode:1997PNAS...94.2036N. doi:10.1073/pnas.94.5.2036. PMC 20038. PMID 9050900.
Sánchez C, Hyttel J (August 1999). "Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding". Cellular and Molecular Neurobiology. 19 (4): 467–489. doi:10.1023/a:1006986824213. PMC 11545528. PMID 10379421.
Anttila SA, Leinonen EV (2001). "A review of the pharmacological and clinical profile of mirtazapine". CNS Drug Reviews. 7 (3): 249–264. doi:10.1111/j.1527-3458.2001.tb00198.x. PMC 6494141. PMID 11607047.
Frazer A (April 1997). "Pharmacology of antidepressants". Journal of Clinical Psychopharmacology. 17 (Suppl 1): 2S – 18S. doi:10.1097/00004714-199704001-00002. PMID 9090573.
Berg KA, Harvey JA, Spampinato U, Clarke WP (December 2005). "Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors". Trends in Pharmacological Sciences. 26 (12): 625–630. doi:10.1016/j.tips.2005.10.008. PMID 16269190.
Del'Guidice T, Lemay F, Lemasson M, Levasseur-Moreau J, Manta S, Etievant A, et al. (April 2014). "Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation". Neuropsychopharmacology. 39 (5): 1125–1134. doi:10.1038/npp.2013.313. PMC 3957106. PMID 24196946.
Esposito E (February 2006). "Serotonin-dopamine interaction as a focus of novel antidepressant drugs". Current Drug Targets. 7 (2): 177–185. doi:10.2174/138945006775515455. PMID 16475959.
Bubar MJ, Cunningham KA (2006). "Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence". Current Topics in Medicinal Chemistry. 6 (18): 1971–1985. doi:10.2174/156802606778522131. PMID 17017968.
Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, et al. (June 2007). "Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation". The Journal of Neuroscience. 27 (26): 6956–6964. doi:10.1523/JNEUROSCI.2584-06.2007. PMC 6672238. PMID 17596444.
Birzniece V, Johansson IM, Wang MD, Bäckström T, Olsson T (February 2002). "Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats". Neuroscience Letters. 319 (3): 157–161. doi:10.1016/S0304-3940(01)02570-8. PMID 11834317. S2CID 6902168.
Kishore S, Stamm S (January 2006). "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C". Science. 311 (5758): 230–232. Bibcode:2006Sci...311..230K. doi:10.1126/science.1118265. PMID 16357227. S2CID 44527461.
Sahoo T, del Gaudio D, German JR, Shinawi M, Peters SU, Person RE, et al. (June 2008). "Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster". Nature Genetics. 40 (6): 719–721. doi:10.1038/ng.158. PMC 2705197. PMID 18500341.
Adhikari AS, Yadav A, Pandit S, Kumar S, Pandey VK, Maurya AK, et al. (26 November 2025). "Synthesis and Evaluation of Novel Aza-Aromatics as Dual 5-HT2A and 5-HT2C Receptor Agonists". ACS Medicinal Chemistry Letters. doi:10.1021/acsmedchemlett.5c00505. ISSN 1948-5875. Retrieved 29 November 2025.
Rodriguez MM, Overshiner C, Leander JD, Li X, Morrow D, Conway RG, et al. (2017). "Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive-Compulsive Disorder". Frontiers in Psychiatry. 8: 89. doi:10.3389/fpsyt.2017.00089. PMC 5438973. PMID 28588509.
Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, et al. (June 2014). "Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors". Journal of Medicinal Chemistry. 57 (12): 5258–5269. doi:10.1021/jm5003292. PMID 24878222.
McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011). "A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference". Neuroscience Letters. 505 (1): 10–13. doi:10.1016/j.neulet.2011.07.036. PMC 3213641. PMID 21827831.
Stahl SM, Sommer B, Allers KA (January 2011). "Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder". The Journal of Sexual Medicine. 8 (1): 15–27. doi:10.1111/j.1743-6109.2010.02032.x. PMID 20840530.
Dekeyne A, Brocco M, Loiseau F, Gobert A, Rivet JM, Di Cara B, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization". The Journal of Pharmacology and Experimental Therapeutics. 340 (3): 765–780. doi:10.1124/jpet.111.187534. PMID 22178753. S2CID 11363664.
De Deurwaerdère P, Chagraoui A, Cunningham KA (2020). "Editorial: Contemporary Perspective on 5-HT_2C Receptor Function and Its Pharmacological Targeting". Frontiers in Pharmacology. 11 606414. doi:10.3389/fphar.2020.606414. PMC 7724505. PMID 33324228.
Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, et al. (January 2019). "Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT_2C Receptor". Journal of Medicinal Chemistry. 62 (1): 288–305. doi:10.1021/acs.jmedchem.8b00401. PMC 6533912. PMID 29620897.
Wold EA, Garcia EJ, Wild CT, Miszkiel JM, Soto CA, Chen J, et al. (July 2020). "Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties". Journal of Medicinal Chemistry. 63 (14): 7529–7544. doi:10.1021/acs.jmedchem.9b01953. PMC 8434884. PMID 32567857.
García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, et al. (December 2017). "A Positive Allosteric Modulator of the Serotonin 5-HT_2C Receptor for Obesity". Journal of Medicinal Chemistry. 60 (23): 9575–9584. doi:10.1021/acs.jmedchem.7b00994. PMID 29116785.
Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, et al. (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". The Journal of Biological Chemistry. 276 (16): 12974–12982. doi:10.1074/jbc.M008089200. PMID 11150294.
Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Letters. 424 (1–2): 63–68. Bibcode:1998FEBSL.424...63U. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516.
Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, et al. (May 1997). "Regulation of serotonin-2C receptor G-protein coupling by RNA editing". Nature. 387 (6630): 303–308. Bibcode:1997Natur.387..303B. doi:10.1038/387303a0. PMID 9153397. S2CID 4247011.
Fitzgerald LW, Iyer G, Conklin DS, Krause CM, Marshall A, Patterson JP, et al. (August 1999). "Messenger RNA editing of the human serotonin 5-HT2C receptor". Neuropsychopharmacology. 21 (2 Suppl): 82S – 90S. doi:10.1016/S0893-133X(99)00004-4. PMID 10432493.
Flomen R, Knight J, Sham P, Kerwin R, Makoff A (2004). "Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene". Nucleic Acids Research. 32 (7): 2113–2122. doi:10.1093/nar/gkh536. PMC 407821. PMID 15087490.
Hackler EA, Airey DC, Shannon CC, Sodhi MS, Sanders-Bush E (May 2006). "5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice". Neuroscience Research. 55 (1): 96–104. doi:10.1016/j.neures.2006.02.005. PMID 16580757. S2CID 3799598.
Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB, Sanders-Bush E (April 1999). "RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity". The Journal of Biological Chemistry. 274 (14): 9472–9478. doi:10.1074/jbc.274.14.9472. PMID 10092629.
Wang Q, O'Brien PJ, Chen CX, Cho DS, Murray JM, Nishikura K (March 2000). "Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin2C receptors". Journal of Neurochemistry. 74 (3): 1290–1300. doi:10.1046/j.1471-4159.2000.741290.x. PMID 10693963.
Yang W, Wang Q, Kanes SJ, Murray JM, Nishikura K (April 2004). "Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy". Brain Research. Molecular Brain Research. 124 (1): 70–78. doi:10.1016/j.molbrainres.2004.02.010. PMID 15093687.
Sukma M, Tohda M, Watanabe H, Matsumoto K (August 2005). "The mRNA expression differences of RNA editing enzymes in differentiated and undifferentiated NG108-15 cells". Journal of Pharmacological Sciences. 98 (4): 467–470. doi:10.1254/jphs.SC0050074. PMID 16082172.
Tohda M, Sukma M, Watanabe H (October 2004). "RNA editing and short variant of serotonin 2C receptor mRNA in neuronally differentiated NG108-15 cells". Journal of Pharmacological Sciences. 96 (2): 164–169. doi:10.1254/jphs.FP0040227. PMID 15492466.
Hartner JC, Schmittwolf C, Kispert A, Müller AM, Higuchi M, Seeburg PH (February 2004). "Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1". The Journal of Biological Chemistry. 279 (6): 4894–4902. doi:10.1074/jbc.M311347200. PMID 14615479.
Backstrom JR, Chang MS, Chu H, Niswender CM, Sanders-Bush E (August 1999). "Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD)". Neuropsychopharmacology. 21 (2 Suppl): 77S – 81S. doi:10.1016/S0893-133X(99)00005-6. PMID 10432492. S2CID 25007217.
Marion S, Weiner DM, Caron MG (January 2004). "RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms". The Journal of Biological Chemistry. 279 (4): 2945–2954. doi:10.1074/jbc.M308742200. PMID 14602721.
Baxter G, Kennett G, Blaney F, Blackburn T (March 1995). "5-HT2 receptor subtypes: a family re-united?". Trends in Pharmacological Sciences. 16 (3): 105–110. doi:10.1016/S0165-6147(00)88991-9. PMID 7792930.
Iwamoto K, Kato T (August 2003). "RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders". Neuroscience Letters. 346 (3): 169–172. doi:10.1016/S0304-3940(03)00608-6. PMID 12853111. S2CID 24977282.
Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C (April 2002). "Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims". Neuron. 34 (3): 349–356. doi:10.1016/S0896-6273(02)00660-8. PMID 11988167.
Iwamoto K, Nakatani N, Bundo M, Yoshikawa T, Kato T (September 2005). "Altered RNA editing of serotonin 2C receptor in a rat model of depression". Neuroscience Research. 53 (1): 69–76. doi:10.1016/j.neures.2005.06.001. PMID 16005997. S2CID 25363004.
Gurevich I, Englander MT, Adlersberg M, Siegal NB, Schmauss C (December 2002). "Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission". The Journal of Neuroscience. 22 (24): 10529–10532. doi:10.1523/JNEUROSCI.22-24-10529.2002. PMC 6758441. PMID 12486144.

ensembl.org (Global: 1,626^th place; English: 1,007^th place)

May2017.archive.ensembl.org

GRCm38: Ensembl release 89: ENSMUSG00000041380 – Ensembl, May 2017

harvard.edu (Global: 18^th place; English: 17^th place)

ui.adsabs.harvard.edu

Hoffman BJ, Mezey E (April 1989). "Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain". FEBS Letters. 247 (2): 453–462. Bibcode:1989FEBSL.247..453H. doi:10.1016/0014-5793(89)81390-0. PMID 2714444. S2CID 23825490.
Ni YG, Miledi R (March 1997). "Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac)". Proceedings of the National Academy of Sciences of the United States of America. 94 (5): 2036–2040. Bibcode:1997PNAS...94.2036N. doi:10.1073/pnas.94.5.2036. PMC 20038. PMID 9050900.
Kishore S, Stamm S (January 2006). "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C". Science. 311 (5758): 230–232. Bibcode:2006Sci...311..230K. doi:10.1126/science.1118265. PMID 16357227. S2CID 44527461.
Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Letters. 424 (1–2): 63–68. Bibcode:1998FEBSL.424...63U. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516.
Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, et al. (May 1997). "Regulation of serotonin-2C receptor G-protein coupling by RNA editing". Nature. 387 (6630): 303–308. Bibcode:1997Natur.387..303B. doi:10.1038/387303a0. PMID 9153397. S2CID 4247011.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Stam NJ, Vanderheyden P, van Alebeek C, Klomp J, de Boer T, van Delft AM, et al. (November 1994). "Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor". European Journal of Pharmacology. 269 (3): 339–348. doi:10.1016/0922-4106(94)90042-6. PMID 7895773.
Herrick-Davis K, Grinde E, Lindsley T, Cowan A, Mazurkiewicz JE (July 2012). "Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers". The Journal of Biological Chemistry. 287 (28): 23604–23614. doi:10.1074/jbc.M112.350249. PMC 3390635. PMID 22593582.
Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, et al. (February 2018). "5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology". Cell. 172 (4): 719–730.e14. doi:10.1016/j.cell.2018.01.001. PMC 6309861. PMID 29398112.
Abramowski D, Rigo M, Duc D, Hoyer D, Staufenbiel M (December 1995). "Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera". Neuropharmacology. 34 (12): 1635–1645. doi:10.1016/0028-3908(95)00138-7. PMID 8788961. S2CID 45542707.
Hoffman BJ, Mezey E (April 1989). "Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain". FEBS Letters. 247 (2): 453–462. Bibcode:1989FEBSL.247..453H. doi:10.1016/0014-5793(89)81390-0. PMID 2714444. S2CID 23825490.
Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA (March 2005). "Modulation of dopamine release by striatal 5-HT2C receptors". Synapse. 55 (4): 242–251. doi:10.1002/syn.20109. PMID 15668911. S2CID 11405860.
Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (July 2007). "Serotonin 5-HT(2C) receptors regulate anxiety-like behavior". Genes, Brain, and Behavior. 6 (5): 491–496. doi:10.1111/j.1601-183X.2007.00316.x. PMID 17451451.
Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, et al. (May 2001). "RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy". Neuropsychopharmacology. 24 (5): 478–491. doi:10.1016/S0893-133X(00)00223-2. PMID 11282248.
Guaiana G, Gupta S, Chiodo D, Davies SJ, Haederle K, Koesters M (December 2013). "Agomelatine versus other antidepressive agents for major depression". The Cochrane Database of Systematic Reviews. 2013 (12) CD008851. doi:10.1002/14651858.CD008851.pub2. PMC 11289707. PMID 24343836.
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018). "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis". Lancet. 391 (10128): 1357–1366. doi:10.1016/S0140-6736(17)32802-7. PMC 5889788. PMID 29477251.
Roth BL, Craigo SC, Choudhary MS, Uluer A, Monsma FJ, Shen Y, et al. (March 1994). "Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors". The Journal of Pharmacology and Experimental Therapeutics. 268 (3): 1403–1410. PMID 7908055.
Ni YG, Miledi R (March 1997). "Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac)". Proceedings of the National Academy of Sciences of the United States of America. 94 (5): 2036–2040. Bibcode:1997PNAS...94.2036N. doi:10.1073/pnas.94.5.2036. PMC 20038. PMID 9050900.
Sánchez C, Hyttel J (August 1999). "Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding". Cellular and Molecular Neurobiology. 19 (4): 467–489. doi:10.1023/a:1006986824213. PMC 11545528. PMID 10379421.
Anttila SA, Leinonen EV (2001). "A review of the pharmacological and clinical profile of mirtazapine". CNS Drug Reviews. 7 (3): 249–264. doi:10.1111/j.1527-3458.2001.tb00198.x. PMC 6494141. PMID 11607047.
Frazer A (April 1997). "Pharmacology of antidepressants". Journal of Clinical Psychopharmacology. 17 (Suppl 1): 2S – 18S. doi:10.1097/00004714-199704001-00002. PMID 9090573.
Berg KA, Harvey JA, Spampinato U, Clarke WP (December 2005). "Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors". Trends in Pharmacological Sciences. 26 (12): 625–630. doi:10.1016/j.tips.2005.10.008. PMID 16269190.
Del'Guidice T, Lemay F, Lemasson M, Levasseur-Moreau J, Manta S, Etievant A, et al. (April 2014). "Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation". Neuropsychopharmacology. 39 (5): 1125–1134. doi:10.1038/npp.2013.313. PMC 3957106. PMID 24196946.
Esposito E (February 2006). "Serotonin-dopamine interaction as a focus of novel antidepressant drugs". Current Drug Targets. 7 (2): 177–185. doi:10.2174/138945006775515455. PMID 16475959.
Bubar MJ, Cunningham KA (2006). "Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence". Current Topics in Medicinal Chemistry. 6 (18): 1971–1985. doi:10.2174/156802606778522131. PMID 17017968.
Jørgensen HS (November 2007). "Studies on the neuroendocrine role of serotonin". Danish Medical Bulletin. 54 (4): 266–288. PMID 18208678.
Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, et al. (June 2007). "Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation". The Journal of Neuroscience. 27 (26): 6956–6964. doi:10.1523/JNEUROSCI.2584-06.2007. PMC 6672238. PMID 17596444.
Birzniece V, Johansson IM, Wang MD, Bäckström T, Olsson T (February 2002). "Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats". Neuroscience Letters. 319 (3): 157–161. doi:10.1016/S0304-3940(01)02570-8. PMID 11834317. S2CID 6902168.
Kishore S, Stamm S (January 2006). "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C". Science. 311 (5758): 230–232. Bibcode:2006Sci...311..230K. doi:10.1126/science.1118265. PMID 16357227. S2CID 44527461.
Sahoo T, del Gaudio D, German JR, Shinawi M, Peters SU, Person RE, et al. (June 2008). "Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster". Nature Genetics. 40 (6): 719–721. doi:10.1038/ng.158. PMC 2705197. PMID 18500341.
Rodriguez MM, Overshiner C, Leander JD, Li X, Morrow D, Conway RG, et al. (2017). "Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive-Compulsive Disorder". Frontiers in Psychiatry. 8: 89. doi:10.3389/fpsyt.2017.00089. PMC 5438973. PMID 28588509.
Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, et al. (June 2014). "Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors". Journal of Medicinal Chemistry. 57 (12): 5258–5269. doi:10.1021/jm5003292. PMID 24878222.
McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011). "A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference". Neuroscience Letters. 505 (1): 10–13. doi:10.1016/j.neulet.2011.07.036. PMC 3213641. PMID 21827831.
Stahl SM, Sommer B, Allers KA (January 2011). "Multifunctional pharmacology of flibanserin: possible mechanism of therapeutic action in hypoactive sexual desire disorder". The Journal of Sexual Medicine. 8 (1): 15–27. doi:10.1111/j.1743-6109.2010.02032.x. PMID 20840530.
Dekeyne A, Brocco M, Loiseau F, Gobert A, Rivet JM, Di Cara B, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization". The Journal of Pharmacology and Experimental Therapeutics. 340 (3): 765–780. doi:10.1124/jpet.111.187534. PMID 22178753. S2CID 11363664.
De Deurwaerdère P, Chagraoui A, Cunningham KA (2020). "Editorial: Contemporary Perspective on 5-HT_2C Receptor Function and Its Pharmacological Targeting". Frontiers in Pharmacology. 11 606414. doi:10.3389/fphar.2020.606414. PMC 7724505. PMID 33324228.
Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, et al. (January 2019). "Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT_2C Receptor". Journal of Medicinal Chemistry. 62 (1): 288–305. doi:10.1021/acs.jmedchem.8b00401. PMC 6533912. PMID 29620897.
Wold EA, Garcia EJ, Wild CT, Miszkiel JM, Soto CA, Chen J, et al. (July 2020). "Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties". Journal of Medicinal Chemistry. 63 (14): 7529–7544. doi:10.1021/acs.jmedchem.9b01953. PMC 8434884. PMID 32567857.
García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, et al. (December 2017). "A Positive Allosteric Modulator of the Serotonin 5-HT_2C Receptor for Obesity". Journal of Medicinal Chemistry. 60 (23): 9575–9584. doi:10.1021/acs.jmedchem.7b00994. PMID 29116785.
Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, et al. (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". The Journal of Biological Chemistry. 276 (16): 12974–12982. doi:10.1074/jbc.M008089200. PMID 11150294.
Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Letters. 424 (1–2): 63–68. Bibcode:1998FEBSL.424...63U. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516.
Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, et al. (May 1997). "Regulation of serotonin-2C receptor G-protein coupling by RNA editing". Nature. 387 (6630): 303–308. Bibcode:1997Natur.387..303B. doi:10.1038/387303a0. PMID 9153397. S2CID 4247011.
Fitzgerald LW, Iyer G, Conklin DS, Krause CM, Marshall A, Patterson JP, et al. (August 1999). "Messenger RNA editing of the human serotonin 5-HT2C receptor". Neuropsychopharmacology. 21 (2 Suppl): 82S – 90S. doi:10.1016/S0893-133X(99)00004-4. PMID 10432493.
Flomen R, Knight J, Sham P, Kerwin R, Makoff A (2004). "Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene". Nucleic Acids Research. 32 (7): 2113–2122. doi:10.1093/nar/gkh536. PMC 407821. PMID 15087490.
Hackler EA, Airey DC, Shannon CC, Sodhi MS, Sanders-Bush E (May 2006). "5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice". Neuroscience Research. 55 (1): 96–104. doi:10.1016/j.neures.2006.02.005. PMID 16580757. S2CID 3799598.
Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB, Sanders-Bush E (April 1999). "RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity". The Journal of Biological Chemistry. 274 (14): 9472–9478. doi:10.1074/jbc.274.14.9472. PMID 10092629.
Wang Q, O'Brien PJ, Chen CX, Cho DS, Murray JM, Nishikura K (March 2000). "Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin2C receptors". Journal of Neurochemistry. 74 (3): 1290–1300. doi:10.1046/j.1471-4159.2000.741290.x. PMID 10693963.
Yang W, Wang Q, Kanes SJ, Murray JM, Nishikura K (April 2004). "Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy". Brain Research. Molecular Brain Research. 124 (1): 70–78. doi:10.1016/j.molbrainres.2004.02.010. PMID 15093687.
Sukma M, Tohda M, Watanabe H, Matsumoto K (August 2005). "The mRNA expression differences of RNA editing enzymes in differentiated and undifferentiated NG108-15 cells". Journal of Pharmacological Sciences. 98 (4): 467–470. doi:10.1254/jphs.SC0050074. PMID 16082172.
Tohda M, Sukma M, Watanabe H (October 2004). "RNA editing and short variant of serotonin 2C receptor mRNA in neuronally differentiated NG108-15 cells". Journal of Pharmacological Sciences. 96 (2): 164–169. doi:10.1254/jphs.FP0040227. PMID 15492466.
Hartner JC, Schmittwolf C, Kispert A, Müller AM, Higuchi M, Seeburg PH (February 2004). "Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1". The Journal of Biological Chemistry. 279 (6): 4894–4902. doi:10.1074/jbc.M311347200. PMID 14615479.
Backstrom JR, Chang MS, Chu H, Niswender CM, Sanders-Bush E (August 1999). "Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD)". Neuropsychopharmacology. 21 (2 Suppl): 77S – 81S. doi:10.1016/S0893-133X(99)00005-6. PMID 10432492. S2CID 25007217.
Marion S, Weiner DM, Caron MG (January 2004). "RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms". The Journal of Biological Chemistry. 279 (4): 2945–2954. doi:10.1074/jbc.M308742200. PMID 14602721.
Baxter G, Kennett G, Blaney F, Blackburn T (March 1995). "5-HT2 receptor subtypes: a family re-united?". Trends in Pharmacological Sciences. 16 (3): 105–110. doi:10.1016/S0165-6147(00)88991-9. PMID 7792930.
Iwamoto K, Kato T (August 2003). "RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders". Neuroscience Letters. 346 (3): 169–172. doi:10.1016/S0304-3940(03)00608-6. PMID 12853111. S2CID 24977282.
Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C (April 2002). "Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims". Neuron. 34 (3): 349–356. doi:10.1016/S0896-6273(02)00660-8. PMID 11988167.
Iwamoto K, Nakatani N, Bundo M, Yoshikawa T, Kato T (September 2005). "Altered RNA editing of serotonin 2C receptor in a rat model of depression". Neuroscience Research. 53 (1): 69–76. doi:10.1016/j.neures.2005.06.001. PMID 16005997. S2CID 25363004.
Gurevich I, Englander MT, Adlersberg M, Siegal NB, Schmauss C (December 2002). "Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission". The Journal of Neuroscience. 22 (24): 10529–10532. doi:10.1523/JNEUROSCI.22-24-10529.2002. PMC 6758441. PMID 12486144.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: HTR2C 5-hydroxytryptamine (serotonin) receptor 2C".
Herrick-Davis K, Grinde E, Lindsley T, Cowan A, Mazurkiewicz JE (July 2012). "Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers". The Journal of Biological Chemistry. 287 (28): 23604–23614. doi:10.1074/jbc.M112.350249. PMC 3390635. PMID 22593582.
Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, et al. (February 2018). "5-HT_2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology". Cell. 172 (4): 719–730.e14. doi:10.1016/j.cell.2018.01.001. PMC 6309861. PMID 29398112.
Guaiana G, Gupta S, Chiodo D, Davies SJ, Haederle K, Koesters M (December 2013). "Agomelatine versus other antidepressive agents for major depression". The Cochrane Database of Systematic Reviews. 2013 (12) CD008851. doi:10.1002/14651858.CD008851.pub2. PMC 11289707. PMID 24343836.
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al. (April 2018). "Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis". Lancet. 391 (10128): 1357–1366. doi:10.1016/S0140-6736(17)32802-7. PMC 5889788. PMID 29477251.
Ni YG, Miledi R (March 1997). "Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac)". Proceedings of the National Academy of Sciences of the United States of America. 94 (5): 2036–2040. Bibcode:1997PNAS...94.2036N. doi:10.1073/pnas.94.5.2036. PMC 20038. PMID 9050900.
Sánchez C, Hyttel J (August 1999). "Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding". Cellular and Molecular Neurobiology. 19 (4): 467–489. doi:10.1023/a:1006986824213. PMC 11545528. PMID 10379421.
Anttila SA, Leinonen EV (2001). "A review of the pharmacological and clinical profile of mirtazapine". CNS Drug Reviews. 7 (3): 249–264. doi:10.1111/j.1527-3458.2001.tb00198.x. PMC 6494141. PMID 11607047.
Del'Guidice T, Lemay F, Lemasson M, Levasseur-Moreau J, Manta S, Etievant A, et al. (April 2014). "Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation". Neuropsychopharmacology. 39 (5): 1125–1134. doi:10.1038/npp.2013.313. PMC 3957106. PMID 24196946.
Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, et al. (June 2007). "Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation". The Journal of Neuroscience. 27 (26): 6956–6964. doi:10.1523/JNEUROSCI.2584-06.2007. PMC 6672238. PMID 17596444.
Sahoo T, del Gaudio D, German JR, Shinawi M, Peters SU, Person RE, et al. (June 2008). "Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster". Nature Genetics. 40 (6): 719–721. doi:10.1038/ng.158. PMC 2705197. PMID 18500341.
Rodriguez MM, Overshiner C, Leander JD, Li X, Morrow D, Conway RG, et al. (2017). "Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive-Compulsive Disorder". Frontiers in Psychiatry. 8: 89. doi:10.3389/fpsyt.2017.00089. PMC 5438973. PMID 28588509.
McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011). "A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference". Neuroscience Letters. 505 (1): 10–13. doi:10.1016/j.neulet.2011.07.036. PMC 3213641. PMID 21827831.
De Deurwaerdère P, Chagraoui A, Cunningham KA (2020). "Editorial: Contemporary Perspective on 5-HT_2C Receptor Function and Its Pharmacological Targeting". Frontiers in Pharmacology. 11 606414. doi:10.3389/fphar.2020.606414. PMC 7724505. PMID 33324228.
Wild CT, Miszkiel JM, Wold EA, Soto CA, Ding C, Hartley RM, et al. (January 2019). "Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT_2C Receptor". Journal of Medicinal Chemistry. 62 (1): 288–305. doi:10.1021/acs.jmedchem.8b00401. PMC 6533912. PMID 29620897.
Wold EA, Garcia EJ, Wild CT, Miszkiel JM, Soto CA, Chen J, et al. (July 2020). "Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT_2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties". Journal of Medicinal Chemistry. 63 (14): 7529–7544. doi:10.1021/acs.jmedchem.9b01953. PMC 8434884. PMID 32567857.
Flomen R, Knight J, Sham P, Kerwin R, Makoff A (2004). "Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene". Nucleic Acids Research. 32 (7): 2113–2122. doi:10.1093/nar/gkh536. PMC 407821. PMID 15087490.
Gurevich I, Englander MT, Adlersberg M, Siegal NB, Schmauss C (December 2002). "Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission". The Journal of Neuroscience. 22 (24): 10529–10532. doi:10.1523/JNEUROSCI.22-24-10529.2002. PMC 6758441. PMID 12486144.

semanticscholar.org (Global: 11^th place; English: 8^th place)

api.semanticscholar.org

Abramowski D, Rigo M, Duc D, Hoyer D, Staufenbiel M (December 1995). "Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera". Neuropharmacology. 34 (12): 1635–1645. doi:10.1016/0028-3908(95)00138-7. PMID 8788961. S2CID 45542707.
Hoffman BJ, Mezey E (April 1989). "Distribution of serotonin 5-HT1C receptor mRNA in adult rat brain". FEBS Letters. 247 (2): 453–462. Bibcode:1989FEBSL.247..453H. doi:10.1016/0014-5793(89)81390-0. PMID 2714444. S2CID 23825490.
Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA (March 2005). "Modulation of dopamine release by striatal 5-HT2C receptors". Synapse. 55 (4): 242–251. doi:10.1002/syn.20109. PMID 15668911. S2CID 11405860.
Birzniece V, Johansson IM, Wang MD, Bäckström T, Olsson T (February 2002). "Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats". Neuroscience Letters. 319 (3): 157–161. doi:10.1016/S0304-3940(01)02570-8. PMID 11834317. S2CID 6902168.
Kishore S, Stamm S (January 2006). "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C". Science. 311 (5758): 230–232. Bibcode:2006Sci...311..230K. doi:10.1126/science.1118265. PMID 16357227. S2CID 44527461.
Dekeyne A, Brocco M, Loiseau F, Gobert A, Rivet JM, Di Cara B, et al. (March 2012). "S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization". The Journal of Pharmacology and Experimental Therapeutics. 340 (3): 765–780. doi:10.1124/jpet.111.187534. PMID 22178753. S2CID 11363664.
Burns CM, Chu H, Rueter SM, Hutchinson LK, Canton H, Sanders-Bush E, et al. (May 1997). "Regulation of serotonin-2C receptor G-protein coupling by RNA editing". Nature. 387 (6630): 303–308. Bibcode:1997Natur.387..303B. doi:10.1038/387303a0. PMID 9153397. S2CID 4247011.
Hackler EA, Airey DC, Shannon CC, Sodhi MS, Sanders-Bush E (May 2006). "5-HT(2C) receptor RNA editing in the amygdala of C57BL/6J, DBA/2J, and BALB/cJ mice". Neuroscience Research. 55 (1): 96–104. doi:10.1016/j.neures.2006.02.005. PMID 16580757. S2CID 3799598.
Backstrom JR, Chang MS, Chu H, Niswender CM, Sanders-Bush E (August 1999). "Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD)". Neuropsychopharmacology. 21 (2 Suppl): 77S – 81S. doi:10.1016/S0893-133X(99)00005-6. PMID 10432492. S2CID 25007217.
Iwamoto K, Kato T (August 2003). "RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders". Neuroscience Letters. 346 (3): 169–172. doi:10.1016/S0304-3940(03)00608-6. PMID 12853111. S2CID 24977282.
Iwamoto K, Nakatani N, Bundo M, Yoshikawa T, Kato T (September 2005). "Altered RNA editing of serotonin 2C receptor in a rat model of depression". Neuroscience Research. 53 (1): 69–76. doi:10.1016/j.neures.2005.06.001. PMID 16005997. S2CID 25363004.

unc.edu (Global: 1,538^th place; English: 1,042^nd place)

pdsp.unc.edu

Roth BL, Driscol J. "PDSP K_i Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 14 August 2017.

worldcat.org (Global: 5^th place; English: 5^th place)

search.worldcat.org

Adhikari AS, Yadav A, Pandit S, Kumar S, Pandey VK, Maurya AK, et al. (26 November 2025). "Synthesis and Evaluation of Novel Aza-Aromatics as Dual 5-HT2A and 5-HT2C Receptor Agonists". ACS Medicinal Chemistry Letters. doi:10.1021/acsmedchemlett.5c00505. ISSN 1948-5875. Retrieved 29 November 2025.

5-HT2C receptor (English Wikipedia)

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pubs.acs.org

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