Beta-ketoacyl-ACP synthase III (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Beta-ketoacyl-ACP synthase III" in English language version.

refsWebsite

Global rank English rank

43nih.gov

4^th place

31doi.org

2^nd place

8rcsb.org

8,838^th place

8,783^rd place

4semanticscholar.org

11^th place

8^th place

4harvard.edu

18^th place

17^th place

4tballiance.org

low place

3web.archive.org

1^st place

1lshtm.ac.uk

low place

1who.int

195^th place

302^nd place

doi.org

Davies C, Heath RJ, White SW, Rock CO (2000). "The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli". Structure. 8 (2): 185–95. doi:10.1016/S0969-2126(00)00094-0. PMID 10673437.
Han L, Lobo S, Reynolds KA (1998). "Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis". J. Bacteriol. 180 (17): 4481–6. doi:10.1128/JB.180.17.4481-4486.1998. PMC 107458. PMID 9721286.
Khandekar SS, Gentry DR, Van Aller GS, Warren P, Xiang H, Silverman C, Doyle ML, Chambers PA, Konstantinidis AK, Brandt M, Daines RA, Lonsdale JT (2001). "Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)". J. Biol. Chem. 276 (32): 30024–30. doi:10.1074/jbc.M101769200. PMID 11375394. S2CID 40184365.
Li Y, Florova G, Reynolds KA (2005). "Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)". J. Bacteriol. 187 (11): 3795–9. doi:10.1128/JB.187.11.3795-3799.2005. PMC 1112031. PMID 15901703.
Bhatt A, Molle V, Besra GS, Jacobs WR, Kremer L (June 2007). "The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development". Mol. Microbiol. 64 (6): 1442–54. doi:10.1111/j.1365-2958.2007.05761.x. PMID 17555433. S2CID 32586686.
Raman K, Rajagopalan P, Chandra N (October 2005). "Flux Balance Analysis of Mycolic Acid Pathway: Targets for Anti-Tubercular Drugs". PLOS Comput. Biol. 1 (5): e46. Bibcode:2005PLSCB...1...46R. doi:10.1371/journal.pcbi.0010046. PMC 1246807. PMID 16261191.
Sassetti CM, Boyd DH, Rubin EJ (April 2003). "Genes required for mycobacterial growth defined by high density mutagenesis". Mol. Microbiol. 48 (1): 77–84. doi:10.1046/j.1365-2958.2003.03425.x. PMID 12657046. S2CID 21383026.
PDB: 1HND, 1HNH, 1HNJ; Qiu X, Janson CA, Smith WW, Head M, Lonsdale J, Konstantinidis AK (March 2001). "Refined structures of beta-ketoacyl-acyl carrier protein synthase III". J. Mol. Biol. 307 (1): 341–56. doi:10.1006/jmbi.2000.4457. PMID 11243824.
PDB: 1HZP; Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT (June 2001). "Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III". J. Biol. Chem. 276 (23): 20516–22. doi:10.1074/jbc.M010762200. PMID 11278743. S2CID 21814082.
PDB: 1ZOW; Qiu X, Choudhry AE, Janson CA, Grooms M, Daines RA, Lonsdale JT, Khandekar SS (August 2005). "Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus". Protein Sci. 14 (8): 2087–94. doi:10.1110/ps.051501605. PMC 2279320. PMID 15987898.
PDB: 1HN9; Qiu X, Janson CA, Konstantinidis AK, Nwagwu S, Silverman C, Smith WW, Khandekar S, Lonsdale J, Abdel-Meguid SS (December 1999). "Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis". J. Biol. Chem. 274 (51): 36465–71. doi:10.1074/jbc.274.51.36465. PMID 10593943.
Choi KH, Kremer L, Besra GS, Rock CO (September 2000). "Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis". J. Biol. Chem. 275 (36): 28201–7. doi:10.1074/jbc.M003241200. PMID 10840036.
PDB: 1M1M, 2AJ9; Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS (September 2005). "Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity". J. Biol. Chem. 280 (37): 32539–47. doi:10.1074/jbc.M413216200. PMID 16040614.
PDB: 1MZS; Daines RA, Pendrak I, Sham K, Van Aller GS, Konstantinidis AK, Lonsdale JT, Janson CA, Qiu X, Brandt M, Khandekar SS, Silverman C, Head MS (January 2003). "First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling". J. Med. Chem. 46 (1): 5–8. doi:10.1021/jm025571b. PMID 12502353.
Nie Z, Perretta C, Lu J, Su Y, Margosiak S, Gajiwala KS, Cortez J, Nikulin V, Yager KM, Appelt K, Chu S (March 2005). "Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents". J. Med. Chem. 48 (5): 1596–609. doi:10.1021/jm049141s. PMID 15743201.
Ashek A, Cho SJ (March 2006). "A combined approach of docking and 3D QSAR study of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors". Bioorg. Med. Chem. 14 (5): 1474–82. doi:10.1016/j.bmc.2005.10.001. PMID 16275103.
PDB: 1U6S; Musayev F, Sachdeva S, Scarsdale JN, Reynolds KA, Wright HT (March 2005). "Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A". J. Mol. Biol. 346 (5): 1313–21. doi:10.1016/j.jmb.2004.12.044. PMID 15713483.
Veyron-Churlet R, Molle V, Taylor RC, Brown AK, Besra GS, Zanella-Cléon I, Fütterer K, Kremer L (March 2009). "The Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III Activity Is Inhibited by Phosphorylation on a Single Threonine Residue". J. Biol. Chem. 284 (10): 6414–24. doi:10.1074/jbc.M806537200. PMC 2649087. PMID 19074144.
Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA (September 2002). "Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis". Curr Pharm Biotechnol. 3 (3): 197–225. doi:10.2174/1389201023378328. PMID 12164478.
Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS (November 2003). "Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme". Bioorg. Med. Chem. Lett. 13 (21): 3685–8. doi:10.1016/j.bmcl.2003.08.015. PMID 14552758.
Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS (January 2004). "Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme". Bioorg. Med. Chem. Lett. 14 (2): 373–6. doi:10.1016/j.bmcl.2003.10.061. PMID 14698162.
He X, Reeve AM, Desai UR, Kellogg GE, Reynolds KA (August 2004). "1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)". Antimicrob. Agents Chemother. 48 (8): 3093–102. doi:10.1128/AAC.48.8.3093-3102.2004. PMC 478545. PMID 15273125.
Al-Balas Q, Anthony NG, Al-Jaidi B, Alnimr A, Abbott G, Brown AK, Taylor RC, Besra GS, McHugh TD, Gillespie SH, Johnston BF, Mackay SP, Coxon GD (2009). Todd MH (ed.). "Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH". PLOS ONE. 4 (5): e5617. Bibcode:2009PLoSO...4.5617A. doi:10.1371/journal.pone.0005617. PMC 2680598. PMID 19440303.
Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J (February 2006). "Discovery of FabH/FabF Inhibitors from Natural Products". Antimicrob. Agents Chemother. 50 (2): 519–26. doi:10.1128/AAC.50.2.519-526.2006. PMC 1366929. PMID 16436705.
Ondeyka JG, Zink DL, Young K, Painter R, Kodali S, Galgoci A, Collado J, Tormo JR, Basilio A, Vicente F, Wang J, Singh SB (March 2006). "Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy". J. Nat. Prod. 69 (3): 377–80. doi:10.1021/np050416w. PMID 16562839.
Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB (May 2007). "Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties". Proceedings of the National Academy of Sciences of the United States of America. 104 (18): 7612–6. Bibcode:2007PNAS..104.7612W. doi:10.1073/pnas.0700746104. PMC 1863502. PMID 17456595.
Brown AK, Taylor RC, Bhatt A, Fütterer K, Besra GS (2009). Ahmed N (ed.). "Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases". PLOS ONE. 4 (7): e6306. Bibcode:2009PLoSO...4.6306B. doi:10.1371/journal.pone.0006306. PMC 2707616. PMID 19609444.
Viader-Salvadó JM, Garza-González E, Valdez-Leal R, del Bosque-Moncayo MA, Tijerina-Menchaca R, Guerrero-Olazarán M (July 2001). "Mycolic Acid Index Susceptibility Method for Mycobacterium tuberculosis". J. Clin. Microbiol. 39 (7): 2642–5. doi:10.1128/JCM.39.7.2642-2645.2001. PMC 88200. PMID 11427584.
He X, Mueller JP, Reynolds KA (June 2000). "Development of a scintillation proximity assay for beta-ketoacyl-acyl carrier protein synthase III". Anal. Biochem. 282 (1): 107–14. doi:10.1006/abio.2000.4594. PMID 10860506.
Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C (May 2003). "The growing burden of tuberculosis: global trends and interactions with the HIV epidemic" (PDF). Arch. Intern. Med. 163 (9): 1009–21. doi:10.1001/archinte.163.9.1009. PMID 12742798.
Casenghi M, Cole ST, Nathan CF (November 2007). "New Approaches to Filling the Gap in Tuberculosis Drug Discovery". PLOS Med. 4 (11): e293. doi:10.1371/journal.pmed.0040293. PMC 2062479. PMID 17988169.

harvard.edu

ui.adsabs.harvard.edu

Raman K, Rajagopalan P, Chandra N (October 2005). "Flux Balance Analysis of Mycolic Acid Pathway: Targets for Anti-Tubercular Drugs". PLOS Comput. Biol. 1 (5): e46. Bibcode:2005PLSCB...1...46R. doi:10.1371/journal.pcbi.0010046. PMC 1246807. PMID 16261191.
Al-Balas Q, Anthony NG, Al-Jaidi B, Alnimr A, Abbott G, Brown AK, Taylor RC, Besra GS, McHugh TD, Gillespie SH, Johnston BF, Mackay SP, Coxon GD (2009). Todd MH (ed.). "Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH". PLOS ONE. 4 (5): e5617. Bibcode:2009PLoSO...4.5617A. doi:10.1371/journal.pone.0005617. PMC 2680598. PMID 19440303.
Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB (May 2007). "Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties". Proceedings of the National Academy of Sciences of the United States of America. 104 (18): 7612–6. Bibcode:2007PNAS..104.7612W. doi:10.1073/pnas.0700746104. PMC 1863502. PMID 17456595.
Brown AK, Taylor RC, Bhatt A, Fütterer K, Besra GS (2009). Ahmed N (ed.). "Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases". PLOS ONE. 4 (7): e6306. Bibcode:2009PLoSO...4.6306B. doi:10.1371/journal.pone.0006306. PMC 2707616. PMID 19609444.

lshtm.ac.uk

researchonline.lshtm.ac.uk

Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C (May 2003). "The growing burden of tuberculosis: global trends and interactions with the HIV epidemic" (PDF). Arch. Intern. Med. 163 (9): 1009–21. doi:10.1001/archinte.163.9.1009. PMID 12742798.

nih.gov

pubmed.ncbi.nlm.nih.gov

Davies C, Heath RJ, White SW, Rock CO (2000). "The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli". Structure. 8 (2): 185–95. doi:10.1016/S0969-2126(00)00094-0. PMID 10673437.
Han L, Lobo S, Reynolds KA (1998). "Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis". J. Bacteriol. 180 (17): 4481–6. doi:10.1128/JB.180.17.4481-4486.1998. PMC 107458. PMID 9721286.
Khandekar SS, Gentry DR, Van Aller GS, Warren P, Xiang H, Silverman C, Doyle ML, Chambers PA, Konstantinidis AK, Brandt M, Daines RA, Lonsdale JT (2001). "Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)". J. Biol. Chem. 276 (32): 30024–30. doi:10.1074/jbc.M101769200. PMID 11375394. S2CID 40184365.
Li Y, Florova G, Reynolds KA (2005). "Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)". J. Bacteriol. 187 (11): 3795–9. doi:10.1128/JB.187.11.3795-3799.2005. PMC 1112031. PMID 15901703.
Bhatt A, Molle V, Besra GS, Jacobs WR, Kremer L (June 2007). "The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development". Mol. Microbiol. 64 (6): 1442–54. doi:10.1111/j.1365-2958.2007.05761.x. PMID 17555433. S2CID 32586686.
Raman K, Rajagopalan P, Chandra N (October 2005). "Flux Balance Analysis of Mycolic Acid Pathway: Targets for Anti-Tubercular Drugs". PLOS Comput. Biol. 1 (5): e46. Bibcode:2005PLSCB...1...46R. doi:10.1371/journal.pcbi.0010046. PMC 1246807. PMID 16261191.
Sassetti CM, Boyd DH, Rubin EJ (April 2003). "Genes required for mycobacterial growth defined by high density mutagenesis". Mol. Microbiol. 48 (1): 77–84. doi:10.1046/j.1365-2958.2003.03425.x. PMID 12657046. S2CID 21383026.
PDB: 1HND, 1HNH, 1HNJ; Qiu X, Janson CA, Smith WW, Head M, Lonsdale J, Konstantinidis AK (March 2001). "Refined structures of beta-ketoacyl-acyl carrier protein synthase III". J. Mol. Biol. 307 (1): 341–56. doi:10.1006/jmbi.2000.4457. PMID 11243824.
PDB: 1HZP; Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT (June 2001). "Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III". J. Biol. Chem. 276 (23): 20516–22. doi:10.1074/jbc.M010762200. PMID 11278743. S2CID 21814082.
PDB: 1ZOW; Qiu X, Choudhry AE, Janson CA, Grooms M, Daines RA, Lonsdale JT, Khandekar SS (August 2005). "Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus". Protein Sci. 14 (8): 2087–94. doi:10.1110/ps.051501605. PMC 2279320. PMID 15987898.
PDB: 1HN9; Qiu X, Janson CA, Konstantinidis AK, Nwagwu S, Silverman C, Smith WW, Khandekar S, Lonsdale J, Abdel-Meguid SS (December 1999). "Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis". J. Biol. Chem. 274 (51): 36465–71. doi:10.1074/jbc.274.51.36465. PMID 10593943.
Choi KH, Kremer L, Besra GS, Rock CO (September 2000). "Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis". J. Biol. Chem. 275 (36): 28201–7. doi:10.1074/jbc.M003241200. PMID 10840036.
PDB: 1M1M, 2AJ9; Brown AK, Sridharan S, Kremer L, Lindenberg S, Dover LG, Sacchettini JC, Besra GS (September 2005). "Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity". J. Biol. Chem. 280 (37): 32539–47. doi:10.1074/jbc.M413216200. PMID 16040614.
PDB: 1MZS; Daines RA, Pendrak I, Sham K, Van Aller GS, Konstantinidis AK, Lonsdale JT, Janson CA, Qiu X, Brandt M, Khandekar SS, Silverman C, Head MS (January 2003). "First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling". J. Med. Chem. 46 (1): 5–8. doi:10.1021/jm025571b. PMID 12502353.
Nie Z, Perretta C, Lu J, Su Y, Margosiak S, Gajiwala KS, Cortez J, Nikulin V, Yager KM, Appelt K, Chu S (March 2005). "Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents". J. Med. Chem. 48 (5): 1596–609. doi:10.1021/jm049141s. PMID 15743201.
Ashek A, Cho SJ (March 2006). "A combined approach of docking and 3D QSAR study of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors". Bioorg. Med. Chem. 14 (5): 1474–82. doi:10.1016/j.bmc.2005.10.001. PMID 16275103.
PDB: 1U6S; Musayev F, Sachdeva S, Scarsdale JN, Reynolds KA, Wright HT (March 2005). "Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A". J. Mol. Biol. 346 (5): 1313–21. doi:10.1016/j.jmb.2004.12.044. PMID 15713483.
Veyron-Churlet R, Molle V, Taylor RC, Brown AK, Besra GS, Zanella-Cléon I, Fütterer K, Kremer L (March 2009). "The Mycobacterium tuberculosis β-Ketoacyl-Acyl Carrier Protein Synthase III Activity Is Inhibited by Phosphorylation on a Single Threonine Residue". J. Biol. Chem. 284 (10): 6414–24. doi:10.1074/jbc.M806537200. PMC 2649087. PMID 19074144.
Schroeder EK, de Souza N, Santos DS, Blanchard JS, Basso LA (September 2002). "Drugs that inhibit mycolic acid biosynthesis in Mycobacterium tuberculosis". Curr Pharm Biotechnol. 3 (3): 197–225. doi:10.2174/1389201023378328. PMID 12164478.
Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS (November 2003). "Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme". Bioorg. Med. Chem. Lett. 13 (21): 3685–8. doi:10.1016/j.bmcl.2003.08.015. PMID 14552758.
Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS (January 2004). "Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme". Bioorg. Med. Chem. Lett. 14 (2): 373–6. doi:10.1016/j.bmcl.2003.10.061. PMID 14698162.
He X, Reeve AM, Desai UR, Kellogg GE, Reynolds KA (August 2004). "1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)". Antimicrob. Agents Chemother. 48 (8): 3093–102. doi:10.1128/AAC.48.8.3093-3102.2004. PMC 478545. PMID 15273125.
Al-Balas Q, Anthony NG, Al-Jaidi B, Alnimr A, Abbott G, Brown AK, Taylor RC, Besra GS, McHugh TD, Gillespie SH, Johnston BF, Mackay SP, Coxon GD (2009). Todd MH (ed.). "Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH". PLOS ONE. 4 (5): e5617. Bibcode:2009PLoSO...4.5617A. doi:10.1371/journal.pone.0005617. PMC 2680598. PMID 19440303.
Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J (February 2006). "Discovery of FabH/FabF Inhibitors from Natural Products". Antimicrob. Agents Chemother. 50 (2): 519–26. doi:10.1128/AAC.50.2.519-526.2006. PMC 1366929. PMID 16436705.
Ondeyka JG, Zink DL, Young K, Painter R, Kodali S, Galgoci A, Collado J, Tormo JR, Basilio A, Vicente F, Wang J, Singh SB (March 2006). "Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy". J. Nat. Prod. 69 (3): 377–80. doi:10.1021/np050416w. PMID 16562839.
Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB (May 2007). "Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties". Proceedings of the National Academy of Sciences of the United States of America. 104 (18): 7612–6. Bibcode:2007PNAS..104.7612W. doi:10.1073/pnas.0700746104. PMC 1863502. PMID 17456595.
Brown AK, Taylor RC, Bhatt A, Fütterer K, Besra GS (2009). Ahmed N (ed.). "Platensimycin Activity against Mycobacterial β-Ketoacyl-ACP Synthases". PLOS ONE. 4 (7): e6306. Bibcode:2009PLoSO...4.6306B. doi:10.1371/journal.pone.0006306. PMC 2707616. PMID 19609444.
Viader-Salvadó JM, Garza-González E, Valdez-Leal R, del Bosque-Moncayo MA, Tijerina-Menchaca R, Guerrero-Olazarán M (July 2001). "Mycolic Acid Index Susceptibility Method for Mycobacterium tuberculosis". J. Clin. Microbiol. 39 (7): 2642–5. doi:10.1128/JCM.39.7.2642-2645.2001. PMC 88200. PMID 11427584.
He X, Mueller JP, Reynolds KA (June 2000). "Development of a scintillation proximity assay for beta-ketoacyl-acyl carrier protein synthase III". Anal. Biochem. 282 (1): 107–14. doi:10.1006/abio.2000.4594. PMID 10860506.
Corbett EL, Watt CJ, Walker N, Maher D, Williams BG, Raviglione MC, Dye C (May 2003). "The growing burden of tuberculosis: global trends and interactions with the HIV epidemic" (PDF). Arch. Intern. Med. 163 (9): 1009–21. doi:10.1001/archinte.163.9.1009. PMID 12742798.
Casenghi M, Cole ST, Nathan CF (November 2007). "New Approaches to Filling the Gap in Tuberculosis Drug Discovery". PLOS Med. 4 (11): e293. doi:10.1371/journal.pmed.0040293. PMC 2062479. PMID 17988169.

ncbi.nlm.nih.gov

Han L, Lobo S, Reynolds KA (1998). "Characterization of β-Ketoacyl-Acyl Carrier Protein Synthase III from Streptomyces glaucescens and Its Role in Initiation of Fatty Acid Biosynthesis". J. Bacteriol. 180 (17): 4481–6. doi:10.1128/JB.180.17.4481-4486.1998. PMC 107458. PMID 9721286.
Li Y, Florova G, Reynolds KA (2005). "Alteration of the Fatty Acid Profile of Streptomyces coelicolor by Replacement of the Initiation Enzyme 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)". J. Bacteriol. 187 (11): 3795–9. doi:10.1128/JB.187.11.3795-3799.2005. PMC 1112031. PMID 15901703.
Raman K, Rajagopalan P, Chandra N (October 2005). "Flux Balance Analysis of Mycolic Acid Pathway: Targets for Anti-Tubercular Drugs". PLOS Comput. Biol. 1 (5): e46. Bibcode:2005PLSCB...1...46R. doi:10.1371/journal.pcbi.0010046. PMC 1246807. PMID 16261191.
PDB: 1ZOW; Qiu X, Choudhry AE, Janson CA, Grooms M, Daines RA, Lonsdale JT, Khandekar SS (August 2005). "Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus". Protein Sci. 14 (8): 2087–94. doi:10.1110/ps.051501605. PMC 2279320. PMID 15987898.
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rcsb.org

PDB: 1HND, 1HNH, 1HNJ; Qiu X, Janson CA, Smith WW, Head M, Lonsdale J, Konstantinidis AK (March 2001). "Refined structures of beta-ketoacyl-acyl carrier protein synthase III". J. Mol. Biol. 307 (1): 341–56. doi:10.1006/jmbi.2000.4457. PMID 11243824.
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PDB: 1ZOW; Qiu X, Choudhry AE, Janson CA, Grooms M, Daines RA, Lonsdale JT, Khandekar SS (August 2005). "Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus". Protein Sci. 14 (8): 2087–94. doi:10.1110/ps.051501605. PMC 2279320. PMID 15987898.
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PDB: 1UB7Inagaki E, Kuramitsu S, Yokoyama S, Miyano M, Tahirov TH (2007) The Crystal Structure of Beta-Ketoacyl-[Acyl Carrier Protein] Synthase III (Fabh) from Thermus thermophilus.
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PDB: 1MZS; Daines RA, Pendrak I, Sham K, Van Aller GS, Konstantinidis AK, Lonsdale JT, Janson CA, Qiu X, Brandt M, Khandekar SS, Silverman C, Head MS (January 2003). "First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling". J. Med. Chem. 46 (1): 5–8. doi:10.1021/jm025571b. PMID 12502353.
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semanticscholar.org

api.semanticscholar.org

Khandekar SS, Gentry DR, Van Aller GS, Warren P, Xiang H, Silverman C, Doyle ML, Chambers PA, Konstantinidis AK, Brandt M, Daines RA, Lonsdale JT (2001). "Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)". J. Biol. Chem. 276 (32): 30024–30. doi:10.1074/jbc.M101769200. PMID 11375394. S2CID 40184365.
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PDB: 1HZP; Scarsdale JN, Kazanina G, He X, Reynolds KA, Wright HT (June 2001). "Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III". J. Biol. Chem. 276 (23): 20516–22. doi:10.1074/jbc.M010762200. PMID 11278743. S2CID 21814082.

tballiance.org

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who.int

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