DARPin (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "DARPin" in English language version.

refsWebsite

Global rank English rank

20nih.gov

4^th place

15doi.org

2^nd place

5clinicaltrials.gov

5,225^th place

4,062^nd place

4harvard.edu

18^th place

17^th place

3semanticscholar.org

11^th place

8^th place

2uzh.ch

3,633^rd place

3,091^st place

1athebio.com

low place

1worldcat.org

5^th place

1psu.edu

207^th place

136^th place

athebio.com

www.athebio.com

clinicaltrials.gov

Clinical trial number NCT02181517 for "A Study of Abicipar Pegol in Patients With Neovascular Age-related Macular Degeneration" at Clinicaltrials.gov.
Clinical trial number NCT02186119 for "A Study of Abicipar Pegol in Patients With Diabetic Macular Edema" at Clinicaltrials.gov.
Clinical trial number NCT02181504 for "A Study of Abicipar Pegol in Japanese Patients With Neovascular Age-related Macular Degeneration" at Clinicaltrials.gov.
Clinical trial number NCT02194426 for First-in-human Study to Investigate the Safety, Tolerability and Blood Levels of the Test Drug MP0250 in Cancer Patients" at Clinicaltrials.gov.
Clinical trial number NCT01042678 for "Study of MP0112 Intravitreal Injection in Patients With Diabetic Macula Edema" at ClinicalTrials.gov

doi.org

Plückthun A (2015). "Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy". Annu. Rev. Pharmacol. Toxicol. 55 (1): 489–511. doi:10.1146/annurev-pharmtox-010611-134654. PMID 25562645.
Mittl PR, Ernst P, Plückthun A (February 2020). "Chaperone-assisted structure elucidation with DARPins". Current Opinion in Structural Biology. 60: 93–100. doi:10.1016/j.sbi.2019.12.009. PMID 31918361. S2CID 210133068.
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PR, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A (January 2021). "Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism". Science Advances. 7 (5): eabe5504. Bibcode:2021SciA....7.5504D. doi:10.1126/sciadv.abe5504. PMC 7840143. PMID 33571132.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.
Castells-Graells, Roger; Meador, Kyle; Arbing, Mark A.; Sawaya, Michael R.; Gee, Morgan; Cascio, Duilio; Gleave, Emma; Debreczeni, Judit É.; Breed, Jason; Leopold, Karoline; Patel, Ankoor; Jahagirdar, Dushyant; Lyons, Bronwyn; Subramaniam, Sriram; Yeates, Todd (2023-09-12). "Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold". Proceedings of the National Academy of Sciences. 120 (37): e2305494120. doi:10.1073/pnas.2305494120. ISSN 0027-8424. PMC 10500258. PMID 37669364.
Binz HK, Stumpp MT, Forrer P, Amstutz P, Plückthun A (September 2003). "Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins". Journal of Molecular Biology. 332 (2): 489–503. CiteSeerX 10.1.1.627.317. doi:10.1016/S0022-2836(03)00896-9. PMID 12948497.
Mosavi, L. K.; Minor, D. L.; Peng, Z. -Y. (2002). "Consensus-derived structural determinants of the ankyrin repeat motif". Proceedings of the National Academy of Sciences. 99 (25): 16029–16034. Bibcode:2002PNAS...9916029M. doi:10.1073/pnas.252537899. PMC 138559. PMID 12461176.
Binz HK, Amstutz P, Kohl A, Stumpp MT, Briand C, Forrer P, Grütter MG, Plückthun A (May 2004). "High-affinity binders selected from designed ankyrin repeat protein libraries". Nature Biotechnology. 22 (5): 575–582. doi:10.1038/nbt962. PMID 15097997. S2CID 1191035.
Steiner D, Forrer P, Plückthun A (2008). "Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display" (PDF). Mol. Biol. 382 (5): 1211–1227. doi:10.1016/j.jmb.2008.07.085. PMID 18706916.
Steiner D, Forrer P, Stumpp MT, Plückthun A (May 2006). "Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display". Nature Biotechnology. 24 (7): 823–831. doi:10.1038/nbt1218. PMID 16823375. S2CID 869587.
Kohl A, Binz HK, Forrer P, Stumpp MT, Plückthun A, Grütter MG (May 2003). "Designed to be stable: Crystal structure of a consensus ankyrin repeat protein". Proc. Natl. Acad. Sci. USA. 100 (4): 1700–1775. Bibcode:2003PNAS..100.1700K. doi:10.1073/pnas.0337680100. PMC 149896. PMID 12566564.
Wetzel SK, Settanni G, Kenig M, Binz HK, Plückthun A (February 2008). "Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins" (PDF). Journal of Molecular Biology. 376 (1): 241–257. doi:10.1016/j.jmb.2007.11.046. PMID 18164721.
Simon M, Frey R, Zangemeister-Wittke U, Plückthun A (2013). "rthogonal assembly of a designed ankyrin repeat protein-cytotoxin conjugate with a clickable serum albumin module for half-life extension". Bioconjugate Chem. 24 (2): 1955–1966. doi:10.1021/bc200591x. PMID 22188139.
Martin-Killias P, Stefan N, Rothschild S, Plückthun A, Zangemeister-Wittke U (2011). "A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity". Clin. Cancer Res. 17 (1): 100–110. doi:10.1158/1078-0432.CCR-10-1303. PMID 21075824.
Zahnd C, Kawe M, Stumpp MT, de Pasquale C, Tamaskovic R, Nagy-Davidescu G, Dreier B, Schibli R, Binz HK, Waibel R, Plückthun A (2010). "Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size". Cancer Res. 70 (4): 1595–1605. doi:10.1158/0008-5472.CAN-09-2724. PMID 20124480.

harvard.edu

ui.adsabs.harvard.edu

Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PR, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A (January 2021). "Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism". Science Advances. 7 (5): eabe5504. Bibcode:2021SciA....7.5504D. doi:10.1126/sciadv.abe5504. PMC 7840143. PMID 33571132.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.
Mosavi, L. K.; Minor, D. L.; Peng, Z. -Y. (2002). "Consensus-derived structural determinants of the ankyrin repeat motif". Proceedings of the National Academy of Sciences. 99 (25): 16029–16034. Bibcode:2002PNAS...9916029M. doi:10.1073/pnas.252537899. PMC 138559. PMID 12461176.
Kohl A, Binz HK, Forrer P, Stumpp MT, Plückthun A, Grütter MG (May 2003). "Designed to be stable: Crystal structure of a consensus ankyrin repeat protein". Proc. Natl. Acad. Sci. USA. 100 (4): 1700–1775. Bibcode:2003PNAS..100.1700K. doi:10.1073/pnas.0337680100. PMC 149896. PMID 12566564.

nih.gov

pubmed.ncbi.nlm.nih.gov

Plückthun A (2015). "Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy". Annu. Rev. Pharmacol. Toxicol. 55 (1): 489–511. doi:10.1146/annurev-pharmtox-010611-134654. PMID 25562645.
Mittl PR, Ernst P, Plückthun A (February 2020). "Chaperone-assisted structure elucidation with DARPins". Current Opinion in Structural Biology. 60: 93–100. doi:10.1016/j.sbi.2019.12.009. PMID 31918361. S2CID 210133068.
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PR, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A (January 2021). "Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism". Science Advances. 7 (5): eabe5504. Bibcode:2021SciA....7.5504D. doi:10.1126/sciadv.abe5504. PMC 7840143. PMID 33571132.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.
Castells-Graells, Roger; Meador, Kyle; Arbing, Mark A.; Sawaya, Michael R.; Gee, Morgan; Cascio, Duilio; Gleave, Emma; Debreczeni, Judit É.; Breed, Jason; Leopold, Karoline; Patel, Ankoor; Jahagirdar, Dushyant; Lyons, Bronwyn; Subramaniam, Sriram; Yeates, Todd (2023-09-12). "Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold". Proceedings of the National Academy of Sciences. 120 (37): e2305494120. doi:10.1073/pnas.2305494120. ISSN 0027-8424. PMC 10500258. PMID 37669364.
Binz HK, Stumpp MT, Forrer P, Amstutz P, Plückthun A (September 2003). "Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins". Journal of Molecular Biology. 332 (2): 489–503. CiteSeerX 10.1.1.627.317. doi:10.1016/S0022-2836(03)00896-9. PMID 12948497.
Mosavi, L. K.; Minor, D. L.; Peng, Z. -Y. (2002). "Consensus-derived structural determinants of the ankyrin repeat motif". Proceedings of the National Academy of Sciences. 99 (25): 16029–16034. Bibcode:2002PNAS...9916029M. doi:10.1073/pnas.252537899. PMC 138559. PMID 12461176.
Binz HK, Amstutz P, Kohl A, Stumpp MT, Briand C, Forrer P, Grütter MG, Plückthun A (May 2004). "High-affinity binders selected from designed ankyrin repeat protein libraries". Nature Biotechnology. 22 (5): 575–582. doi:10.1038/nbt962. PMID 15097997. S2CID 1191035.
Steiner D, Forrer P, Plückthun A (2008). "Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display" (PDF). Mol. Biol. 382 (5): 1211–1227. doi:10.1016/j.jmb.2008.07.085. PMID 18706916.
Steiner D, Forrer P, Stumpp MT, Plückthun A (May 2006). "Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display". Nature Biotechnology. 24 (7): 823–831. doi:10.1038/nbt1218. PMID 16823375. S2CID 869587.
Kohl A, Binz HK, Forrer P, Stumpp MT, Plückthun A, Grütter MG (May 2003). "Designed to be stable: Crystal structure of a consensus ankyrin repeat protein". Proc. Natl. Acad. Sci. USA. 100 (4): 1700–1775. Bibcode:2003PNAS..100.1700K. doi:10.1073/pnas.0337680100. PMC 149896. PMID 12566564.
Wetzel SK, Settanni G, Kenig M, Binz HK, Plückthun A (February 2008). "Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins" (PDF). Journal of Molecular Biology. 376 (1): 241–257. doi:10.1016/j.jmb.2007.11.046. PMID 18164721.
Simon M, Frey R, Zangemeister-Wittke U, Plückthun A (2013). "rthogonal assembly of a designed ankyrin repeat protein-cytotoxin conjugate with a clickable serum albumin module for half-life extension". Bioconjugate Chem. 24 (2): 1955–1966. doi:10.1021/bc200591x. PMID 22188139.
Martin-Killias P, Stefan N, Rothschild S, Plückthun A, Zangemeister-Wittke U (2011). "A novel fusion toxin derived from an EpCAM-specific designed ankyrin repeat protein has potent antitumor activity". Clin. Cancer Res. 17 (1): 100–110. doi:10.1158/1078-0432.CCR-10-1303. PMID 21075824.
Zahnd C, Kawe M, Stumpp MT, de Pasquale C, Tamaskovic R, Nagy-Davidescu G, Dreier B, Schibli R, Binz HK, Waibel R, Plückthun A (2010). "Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size". Cancer Res. 70 (4): 1595–1605. doi:10.1158/0008-5472.CAN-09-2724. PMID 20124480.

ncbi.nlm.nih.gov

Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PR, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A (January 2021). "Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism". Science Advances. 7 (5): eabe5504. Bibcode:2021SciA....7.5504D. doi:10.1126/sciadv.abe5504. PMC 7840143. PMID 33571132.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.
Castells-Graells, Roger; Meador, Kyle; Arbing, Mark A.; Sawaya, Michael R.; Gee, Morgan; Cascio, Duilio; Gleave, Emma; Debreczeni, Judit É.; Breed, Jason; Leopold, Karoline; Patel, Ankoor; Jahagirdar, Dushyant; Lyons, Bronwyn; Subramaniam, Sriram; Yeates, Todd (2023-09-12). "Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold". Proceedings of the National Academy of Sciences. 120 (37): e2305494120. doi:10.1073/pnas.2305494120. ISSN 0027-8424. PMC 10500258. PMID 37669364.
Mosavi, L. K.; Minor, D. L.; Peng, Z. -Y. (2002). "Consensus-derived structural determinants of the ankyrin repeat motif". Proceedings of the National Academy of Sciences. 99 (25): 16029–16034. Bibcode:2002PNAS...9916029M. doi:10.1073/pnas.252537899. PMC 138559. PMID 12461176.
Kohl A, Binz HK, Forrer P, Stumpp MT, Plückthun A, Grütter MG (May 2003). "Designed to be stable: Crystal structure of a consensus ankyrin repeat protein". Proc. Natl. Acad. Sci. USA. 100 (4): 1700–1775. Bibcode:2003PNAS..100.1700K. doi:10.1073/pnas.0337680100. PMC 149896. PMID 12566564.

psu.edu

citeseerx.ist.psu.edu

Binz HK, Stumpp MT, Forrer P, Amstutz P, Plückthun A (September 2003). "Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins". Journal of Molecular Biology. 332 (2): 489–503. CiteSeerX 10.1.1.627.317. doi:10.1016/S0022-2836(03)00896-9. PMID 12948497.

semanticscholar.org

api.semanticscholar.org

Mittl PR, Ernst P, Plückthun A (February 2020). "Chaperone-assisted structure elucidation with DARPins". Current Opinion in Structural Biology. 60: 93–100. doi:10.1016/j.sbi.2019.12.009. PMID 31918361. S2CID 210133068.
Binz HK, Amstutz P, Kohl A, Stumpp MT, Briand C, Forrer P, Grütter MG, Plückthun A (May 2004). "High-affinity binders selected from designed ankyrin repeat protein libraries". Nature Biotechnology. 22 (5): 575–582. doi:10.1038/nbt962. PMID 15097997. S2CID 1191035.
Steiner D, Forrer P, Stumpp MT, Plückthun A (May 2006). "Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display". Nature Biotechnology. 24 (7): 823–831. doi:10.1038/nbt1218. PMID 16823375. S2CID 869587.

uzh.ch

zora.uzh.ch

Steiner D, Forrer P, Plückthun A (2008). "Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display" (PDF). Mol. Biol. 382 (5): 1211–1227. doi:10.1016/j.jmb.2008.07.085. PMID 18706916.
Wetzel SK, Settanni G, Kenig M, Binz HK, Plückthun A (February 2008). "Folding and unfolding mechanism of highly stable full-consensus ankyrin repeat proteins" (PDF). Journal of Molecular Biology. 376 (1): 241–257. doi:10.1016/j.jmb.2007.11.046. PMID 18164721.

worldcat.org

Castells-Graells, Roger; Meador, Kyle; Arbing, Mark A.; Sawaya, Michael R.; Gee, Morgan; Cascio, Duilio; Gleave, Emma; Debreczeni, Judit É.; Breed, Jason; Leopold, Karoline; Patel, Ankoor; Jahagirdar, Dushyant; Lyons, Bronwyn; Subramaniam, Sriram; Yeates, Todd (2023-09-12). "Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold". Proceedings of the National Academy of Sciences. 120 (37): e2305494120. doi:10.1073/pnas.2305494120. ISSN 0027-8424. PMC 10500258. PMID 37669364.