References analysis of the Wikipedia article "Drug metabolism" in the English version

doi.org

Jakoby WB, Ziegler DM (December 1990). "The enzymes of detoxication". J. Biol. Chem. 265 (34): 20715–8. doi:10.1016/S0021-9258(17)45272-0. PMID 2249981. Archived from the original on 2009-06-21. Retrieved 2012-12-29.

Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (September 2003). "Impact of drug transporter studies on drug discovery and development". Pharmacol. Rev. 55 (3): 425–61. doi:10.1124/pr.55.3.1. PMID 12869659. S2CID 724685.

Thornalley PJ (July 1990). "The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life". Biochem. J. 269 (1): 1–11. doi:10.1042/bj2690001. PMC 1131522. PMID 2198020.

Sies H (March 1997). "Oxidative stress: oxidants and antioxidants". Exp. Physiol. 82 (2): 291–5. doi:10.1113/expphysiol.1997.sp004024. PMID 9129943.

Guengerich FP (June 2001). "Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity". Chem. Res. Toxicol. 14 (6): 611–50. doi:10.1021/tx0002583. PMID 11409933.

Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG (March 2000). "The catalytic pathway of cytochrome p450cam at atomic resolution". Science. 287 (5458): 1615–22. Bibcode:2000Sci...287.1615S. doi:10.1126/science.287.5458.1615. PMID 10698731.

Akagah B, Lormier AT, Fournet A, Figadère B (December 2008). "Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates". Org. Biomol. Chem. 6 (24): 4494–7. doi:10.1039/b815963g. PMID 19039354.

Liston HL, Markowitz JS, DeVane CL (October 2001). "Drug glucuronidation in clinical psychopharmacology". J Clin Psychopharmacol. 21 (5): 500–15. doi:10.1097/00004714-200110000-00008. PMID 11593076. S2CID 6068811.

Badenhorst CP, van der Sluis R, Erasmus E, van Dijk AA (September 2013). "Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation". Expert Opinion on Drug Metabolism & Toxicology. 9 (9): 1139–1153. doi:10.1517/17425255.2013.796929. PMID 23650932. S2CID 23738007. Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A (CoASH). However, because of the small number of pharmaceutical drugs that are conjugated to glycine, the pathway has not yet been characterized in detail. Here, we review the causes and possible consequences of interindividual variation in the glycine conjugation pathway. ...
Figure 1. Glycine conjugation of benzoic acid. The glycine conjugation pathway consists of two steps. First benzoate is ligated to CoASH to form the high-energy benzoyl-CoA thioester. This reaction is catalyzed by the HXM-A and HXM-B medium-chain acid:CoA ligases and requires energy in the form of ATP. ... The benzoyl-CoA is then conjugated to glycine by GLYAT to form hippuric acid, releasing CoASH. In addition to the factors listed in the boxes, the levels of ATP, CoASH, and glycine may influence the overall rate of the glycine conjugation pathway.

Boyland E, Chasseaud LF (1969). "The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis". Adv. Enzymol. Relat. Areas Mol. Biol. Advances in Enzymology – and Related Areas of Molecular Biology. 32: 173–219. doi:10.1002/9780470122778.ch5. ISBN 9780470122778. PMID 4892500.

Homolya L, Váradi A, Sarkadi B (2003). "Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate". BioFactors. 17 (1–4): 103–14. doi:10.1002/biof.5520170111. PMID 12897433. S2CID 7744924.

König J, Nies AT, Cui Y, Leier I, Keppler D (December 1999). "Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance". Biochim. Biophys. Acta. 1461 (2): 377–94. doi:10.1016/S0005-2736(99)00169-8. PMID 10581368.

Heinken A, Hertel J, Acharya G, et al. (19 January 2023). "Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine". Nature Biotechnology. 41 (9): 1320–1331. doi:10.1038/s41587-022-01628-0. PMC 10497413. PMID 36658342.

Gutiérrez-Virgen, Jorge E.; Piña-Pozas, Maricela; Hernández-Tobías, Esther A.; Taja-Chayeb, Lucia; López-González, Ma. de Lourdes; Meraz-Ríos, Marco A.; Gómez, Rocío (2023-04-06). "NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review". PLOS ONE. 18 (4): e0283726. Bibcode:2023PLoSO..1883726G. doi:10.1371/journal.pone.0283726. ISSN 1932-6203. PMC 10079069. PMID 37023111.

Fukunaga, Koya; Kato, Ken; Okusaka, Takuji; Saito, Takeo; Ikeda, Masashi; Yoshida, Teruhiko; Zembutsu, Hitoshi; Iwata, Nakao; Mushiroda, Taisei (2021-03-18). "Functional Characterization of the Effects of N-acetyltransferase 2 Alleles on N-acetylation of Eight Drugs and Worldwide Distribution of Substrate-Specific Diversity". Frontiers in Genetics. 12: 652704. doi:10.3389/fgene.2021.652704. ISSN 1664-8021. PMC 8012690. PMID 33815485.

Muldoon, Megan; Beck, Mollie; Sebree, Nichlas; Yoder, Robin; Ritter, Stacey; Allen, Josiah D.; Alqahtani, Zuhair; Grund, Jaime; Philips, Brooke; Hesse, Kristina; El Rouby, Nihal (February 2024). "Real-world implementation of DPYD and UGT1A1 pharmacogenetic testing in a community-based cancer center". Clinical and Translational Science. 17 (2). doi:10.1111/cts.13704. ISSN 1752-8054. PMC 10818131.

Rostami-Hodjegan A, Tucker GT (February 2007). "Simulation and prediction of in vivo drug metabolism in human populations from in vitro data". Nat Rev Drug Discov. 6 (2): 140–8. doi:10.1038/nrd2173. PMID 17268485. S2CID 205476485.

Neuberger A, Smith RL (1983). "Richard Tecwyn Williams: the man, his work, his impact". Drug Metab. Rev. 14 (3): 559–607. doi:10.3109/03602538308991399. PMID 6347595.

Booth J, Boyland E, Sims P (June 1961). "An enzyme from rat liver catalysing conjugations with glutathione". Biochem. J. 79 (3): 516–24. doi:10.1042/bj0790516. PMC 1205680. PMID 16748905.

Omura T, Sato R (April 1962). "A new cytochrome in liver microsomes". J. Biol. Chem. 237 (4): 1375–6. doi:10.1016/S0021-9258(18)60338-2. PMID 14482007. Archived from the original on 2009-06-21. Retrieved 2012-12-29.

Estabrook RW (December 2003). "A passion for P450s (remembrances of the early history of research on cytochrome P450)". Drug Metab. Dispos. 31 (12): 1461–73. doi:10.1124/dmd.31.12.1461. PMID 14625342.

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jbc.org

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pubmed.ncbi.nlm.nih.gov

Sies H (March 1997). "Oxidative stress: oxidants and antioxidants". Exp. Physiol. 82 (2): 291–5. doi:10.1113/expphysiol.1997.sp004024. PMID 9129943.

Guengerich FP (June 2001). "Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity". Chem. Res. Toxicol. 14 (6): 611–50. doi:10.1021/tx0002583. PMID 11409933.

Commandeur JN, Stijntjes GJ, Vermeulen NP (June 1995). "Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics". Pharmacol. Rev. 47 (2): 271–330. PMID 7568330.

Murphy PJ (June 2001). "Xenobiotic metabolism: a look from the past to the future". Drug Metab. Dispos. 29 (6): 779–80. PMID 11353742. Archived from the original on 2009-06-21. Retrieved 2012-12-29.

Neuberger A, Smith RL (1983). "Richard Tecwyn Williams: the man, his work, his impact". Drug Metab. Rev. 14 (3): 559–607. doi:10.3109/03602538308991399. PMID 6347595.

Booth J, Boyland E, Sims P (June 1961). "An enzyme from rat liver catalysing conjugations with glutathione". Biochem. J. 79 (3): 516–24. doi:10.1042/bj0790516. PMC 1205680. PMID 16748905.

Estabrook RW, Cooper DY, Rosenthal O (1963). "The light reversible carbon monoxide inhibition of steroid C-21 hydroxylase system in adrenal cortex". Biochem Z. 338: 741–55. PMID 14087340.

ncbi.nlm.nih.gov

semanticscholar.org

api.semanticscholar.org

web.archive.org

"Acetonitrile (EHC 154, 1993)". www.inchem.org. Archived from the original on 2017-05-22. Retrieved 2017-05-03.

wiley.com

ascpt.onlinelibrary.wiley.com

Drug metabolism (English Wikipedia)

aspetjournals.org

dmd.aspetjournals.org