Obeticholic acid (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Obeticholic acid" in English language version.

refsWebsite

Global rank English rank

17nih.gov

4^th place

14doi.org

2^nd place

3europa.eu

68^th place

117^th place

3web.archive.org

1^st place

3semanticscholar.org

11^th place

8^th place

3fda.gov

447^th place

338^th place

1canada.ca

1,712^th place

1,063^rd place

1wsj.com

79^th place

65^th place

1clinicaltrials.gov

5,225^th place

4,062^nd place

1lecturio.com

5,619^th place

2,948^th place

1interceptpharma.com

low place

1thestreet.com

4,625^th place

2,767^th place

1pharmaceutical-technology.com

low place

1healio.com

low place

1handle.net

102^nd place

76^th place

canada.ca

"Liver disease". Health Canada. 9 May 2018. Retrieved 13 April 2024.

clinicaltrials.gov

"ClinicalTrials.gov".

doi.org

Gioiello A, Macchiarulo A, Carotti A, Filipponi P, Costantino G, Rizzo G, et al. (April 2011). "Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine". Bioorganic & Medicinal Chemistry. 19 (8): 2650–2658. doi:10.1016/j.bmc.2011.03.004. PMID 21459580.{{cite journal}}: CS1 maint: overridden setting (link)
Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, et al. (August 2002). "6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity". Journal of Medicinal Chemistry. 45 (17): 3569–3572. doi:10.1021/jm025529g. PMID 12166927.{{cite journal}}: CS1 maint: overridden setting (link)
Rizzo G, Renga B, Mencarelli A, Pellicciari R, Fiorucci S (September 2005). "Role of FXR in regulating bile acid homeostasis and relevance for human diseases". Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5 (3): 289–303. doi:10.2174/1568008054863781. PMID 16178789.
Hirschfield GM, Gershwin ME (January 2013). "The immunobiology and pathophysiology of primary biliary cirrhosis". Annual Review of Pathology. 8: 303–330. doi:10.1146/annurev-pathol-020712-164014. PMID 23347352.
Lindor KD (May 2011). "Farnesoid X receptor agonists for primary biliary cirrhosis". Current Opinion in Gastroenterology. 27 (3): 285–288. doi:10.1097/MOG.0b013e32834452c8. PMID 21297469. S2CID 43806943.
Fiorucci S, Cipriani S, Mencarelli A, Baldelli F, Bifulco G, Zampella A (August 2011). "Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA". Mini Reviews in Medicinal Chemistry. 11 (9): 753–762. doi:10.2174/138955711796355258. PMID 21707532.
Hirschfield GM, Mason A, Luketic V, Lindor K, Gordon SC, Mayo M, et al. (April 2015). "Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid". Gastroenterology. 148 (4): 751–61.e8. doi:10.1053/j.gastro.2014.12.005. PMID 25500425.{{cite journal}}: CS1 maint: overridden setting (link)
Adorini L, Pruzanski M, Shapiro D (September 2012). "Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis". Drug Discovery Today. 17 (17–18): 988–997. doi:10.1016/j.drudis.2012.05.012. PMID 22652341.
Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, et al. (September 2013). "Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease". Gastroenterology. 145 (3): 574–82.e1. doi:10.1053/j.gastro.2013.05.042. PMID 23727264.{{cite journal}}: CS1 maint: overridden setting (link)
Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, et al. (March 2015). "Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial". Lancet. 385 (9972): 956–965. doi:10.1016/S0140-6736(14)61933-4. PMC 4447192. PMID 25468160.{{cite journal}}: CS1 maint: overridden setting (link)
Verbeke L, Farre R, Trebicka J, Komuta M, Roskams T, Klein S, et al. (June 2014). "Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats". Hepatology. 59 (6): 2286–2298. doi:10.1002/hep.26939. PMID 24259407. S2CID 205891475.{{cite journal}}: CS1 maint: overridden setting (link)
Walters JR, Tasleem AM, Omer OS, Brydon WG, Dew T, le Roux CW (November 2009). "A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis". Clinical Gastroenterology and Hepatology. 7 (11): 1189–1194. doi:10.1016/j.cgh.2009.04.024. PMID 19426836.
Zhang JH, Nolan JD, Kennie SL, Johnston IM, Dew T, Dixon PH, et al. (May 2013). "Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids". American Journal of Physiology. Gastrointestinal and Liver Physiology. 304 (10): G940–G948. doi:10.1152/ajpgi.00398.2012. PMC 3652069. PMID 23518683.{{cite journal}}: CS1 maint: overridden setting (link)
Walters JR, Johnston IM, Nolan JD, Vassie C, Pruzanski ME, Shapiro DA (January 2015). "The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid". Alimentary Pharmacology & Therapeutics. 41 (1): 54–64. doi:10.1111/apt.12999. hdl:10044/1/21617. PMID 25329562. S2CID 44661338.

europa.eu

ema.europa.eu

"Ocaliva EPAR". European Medicines Agency. 27 July 2010. Retrieved 12 July 2024.
"EMA recommends revoking conditional marketing authorisation for Ocaliva". European Medicines Agency. 28 June 2024. Retrieved 29 June 2024.
"Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 24-27 June 2024". European Medicines Agency. 28 June 2024. Archived from the original on 12 July 2024. Retrieved 12 July 2024.

fda.gov

nctr-crs.fda.gov

"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

fda.gov

"FDA Approves Ocaliva for Rare, Chronic Liver Disease" (Press release). U.S. Food and Drug Administration (FDA). 31 May 2016. Archived from the original on 10 November 2016. Retrieved 15 November 2016.

accessdata.fda.gov

Egan AG. "Letter from Food and Drug Administration to Intercept Pharmaceuticals" (PDF). Center for Drug Evaluation and Research. U.S. Food and Drug Administration (FDA). Retrieved 15 November 2016.

handle.net

hdl.handle.net

Walters JR, Johnston IM, Nolan JD, Vassie C, Pruzanski ME, Shapiro DA (January 2015). "The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid". Alimentary Pharmacology & Therapeutics. 41 (1): 54–64. doi:10.1111/apt.12999. hdl:10044/1/21617. PMID 25329562. S2CID 44661338.

healio.com

"'Unfavorable benefit-risk': FDA panel votes against obeticholic acid approval for NASH". www.healio.com. Retrieved 26 September 2023.

interceptpharma.com

ir.interceptpharma.com

"Press release: Intercept Announces Positive Pivotal Phase 3 POISE Trial Results". Intercept Pharma. Archived from the original on 26 March 2014. Retrieved 27 March 2014.

lecturio.com

"Cirrhosis". The Lecturio Medical Concept Library. 28 September 2020. Retrieved 9 July 2021.

nih.gov

pubmed.ncbi.nlm.nih.gov

Gioiello A, Macchiarulo A, Carotti A, Filipponi P, Costantino G, Rizzo G, et al. (April 2011). "Extending SAR of bile acids as FXR ligands: discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine". Bioorganic & Medicinal Chemistry. 19 (8): 2650–2658. doi:10.1016/j.bmc.2011.03.004. PMID 21459580.{{cite journal}}: CS1 maint: overridden setting (link)
Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, et al. (August 2002). "6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity". Journal of Medicinal Chemistry. 45 (17): 3569–3572. doi:10.1021/jm025529g. PMID 12166927.{{cite journal}}: CS1 maint: overridden setting (link)
Rizzo G, Renga B, Mencarelli A, Pellicciari R, Fiorucci S (September 2005). "Role of FXR in regulating bile acid homeostasis and relevance for human diseases". Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5 (3): 289–303. doi:10.2174/1568008054863781. PMID 16178789.
Hirschfield GM, Gershwin ME (January 2013). "The immunobiology and pathophysiology of primary biliary cirrhosis". Annual Review of Pathology. 8: 303–330. doi:10.1146/annurev-pathol-020712-164014. PMID 23347352.
Lindor KD (May 2011). "Farnesoid X receptor agonists for primary biliary cirrhosis". Current Opinion in Gastroenterology. 27 (3): 285–288. doi:10.1097/MOG.0b013e32834452c8. PMID 21297469. S2CID 43806943.
Fiorucci S, Cipriani S, Mencarelli A, Baldelli F, Bifulco G, Zampella A (August 2011). "Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA". Mini Reviews in Medicinal Chemistry. 11 (9): 753–762. doi:10.2174/138955711796355258. PMID 21707532.
Hirschfield GM, Mason A, Luketic V, Lindor K, Gordon SC, Mayo M, et al. (April 2015). "Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid". Gastroenterology. 148 (4): 751–61.e8. doi:10.1053/j.gastro.2014.12.005. PMID 25500425.{{cite journal}}: CS1 maint: overridden setting (link)
Adorini L, Pruzanski M, Shapiro D (September 2012). "Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis". Drug Discovery Today. 17 (17–18): 988–997. doi:10.1016/j.drudis.2012.05.012. PMID 22652341.
Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, et al. (September 2013). "Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease". Gastroenterology. 145 (3): 574–82.e1. doi:10.1053/j.gastro.2013.05.042. PMID 23727264.{{cite journal}}: CS1 maint: overridden setting (link)
Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, et al. (March 2015). "Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial". Lancet. 385 (9972): 956–965. doi:10.1016/S0140-6736(14)61933-4. PMC 4447192. PMID 25468160.{{cite journal}}: CS1 maint: overridden setting (link)
Verbeke L, Farre R, Trebicka J, Komuta M, Roskams T, Klein S, et al. (June 2014). "Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats". Hepatology. 59 (6): 2286–2298. doi:10.1002/hep.26939. PMID 24259407. S2CID 205891475.{{cite journal}}: CS1 maint: overridden setting (link)
Walters JR, Tasleem AM, Omer OS, Brydon WG, Dew T, le Roux CW (November 2009). "A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis". Clinical Gastroenterology and Hepatology. 7 (11): 1189–1194. doi:10.1016/j.cgh.2009.04.024. PMID 19426836.
Zhang JH, Nolan JD, Kennie SL, Johnston IM, Dew T, Dixon PH, et al. (May 2013). "Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids". American Journal of Physiology. Gastrointestinal and Liver Physiology. 304 (10): G940–G948. doi:10.1152/ajpgi.00398.2012. PMC 3652069. PMID 23518683.{{cite journal}}: CS1 maint: overridden setting (link)
Walters JR, Johnston IM, Nolan JD, Vassie C, Pruzanski ME, Shapiro DA (January 2015). "The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid". Alimentary Pharmacology & Therapeutics. 41 (1): 54–64. doi:10.1111/apt.12999. hdl:10044/1/21617. PMID 25329562. S2CID 44661338.

ncbi.nlm.nih.gov

Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, et al. (March 2015). "Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial". Lancet. 385 (9972): 956–965. doi:10.1016/S0140-6736(14)61933-4. PMC 4447192. PMID 25468160.{{cite journal}}: CS1 maint: overridden setting (link)
Zhang JH, Nolan JD, Kennie SL, Johnston IM, Dew T, Dixon PH, et al. (May 2013). "Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids". American Journal of Physiology. Gastrointestinal and Liver Physiology. 304 (10): G940–G948. doi:10.1152/ajpgi.00398.2012. PMC 3652069. PMID 23518683.{{cite journal}}: CS1 maint: overridden setting (link)

dailymed.nlm.nih.gov

"Ocaliva- obeticholic acid tablet, film coated". DailyMed. Retrieved 17 December 2020.

pharmaceutical-technology.com

"Negative FDA AdCom vote for Intercept's obeticholic acid in NASH". GlobalData Healthcare. Pharmaceutical Technology. 1 June 2023. Retrieved 26 September 2023.

semanticscholar.org

api.semanticscholar.org

Lindor KD (May 2011). "Farnesoid X receptor agonists for primary biliary cirrhosis". Current Opinion in Gastroenterology. 27 (3): 285–288. doi:10.1097/MOG.0b013e32834452c8. PMID 21297469. S2CID 43806943.
Verbeke L, Farre R, Trebicka J, Komuta M, Roskams T, Klein S, et al. (June 2014). "Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats". Hepatology. 59 (6): 2286–2298. doi:10.1002/hep.26939. PMID 24259407. S2CID 205891475.{{cite journal}}: CS1 maint: overridden setting (link)
Walters JR, Johnston IM, Nolan JD, Vassie C, Pruzanski ME, Shapiro DA (January 2015). "The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid". Alimentary Pharmacology & Therapeutics. 41 (1): 54–64. doi:10.1111/apt.12999. hdl:10044/1/21617. PMID 25329562. S2CID 44661338.

thestreet.com

"Intercept Pharma, Government Scientists Spar over Negative Safety of Liver Drug, Emails Show". 20 May 2014.

web.archive.org

"FDA Approves Ocaliva for Rare, Chronic Liver Disease" (Press release). U.S. Food and Drug Administration (FDA). 31 May 2016. Archived from the original on 10 November 2016. Retrieved 15 November 2016.
"Press release: Intercept Announces Positive Pivotal Phase 3 POISE Trial Results". Intercept Pharma. Archived from the original on 26 March 2014. Retrieved 27 March 2014.
"Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 24-27 June 2024". European Medicines Agency. 28 June 2024. Archived from the original on 12 July 2024. Retrieved 12 July 2024.

wsj.com

online.wsj.com

"A $4 Billion Surprise for 45-Person Biotech". The Wall Street Journal. Retrieved 10 January 2014.