Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D (2003). "NF-kappa B functions in synaptic signaling and behavior". Nat. Neurosci.6 (10): 1072–8. PMID12947408. doi:10.1038/nn1110.
Levenson JM, Choi S, Lee SY, Cao YA, Ahn HJ, Worley KC, Pizzi M, Liou HC, Sweatt JD (2004). "A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel". J. Neurosci.24 (16): 3933–43. PMID15102909. doi:10.1523/JNEUROSCI.5646-03.2004.
Freudenthal R, Locatelli F, Hermitte G, Maldonado H, Lafourcade C, Delorenzi A, Romano A (1998). "Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus". Neurosci. Lett.242 (3): 143–6. PMID9530926. doi:10.1016/S0304-3940(98)00059-7.
Merlo E, Freudenthal R, Romano A (2002). "The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus". Neuroscience112 (1): 161–72. PMID12044481. doi:10.1016/S0306-4522(02)00049-0.
Sen R, Baltimore D (1986). "Multiple nuclear factors interact with the immunoglobulin enhancer sequences". Cell46 (5): 705–16. PMID3091258. doi:10.1016/0092-8674(86)90346-6.
Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M (2001). "Activation by IKKalpha of a second, evolutionary conserved, NF-κB signaling pathway". Science293 (5534): 1495–9. PMID11520989. doi:10.1126/science.1062677.
(a) Chandel NS, Trzyna WC, McClintock DS, Schumacker PT (2000). "Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin". J Immunol165 (2): 1013–1021. PMID10878378.; (b) Fitzgerald DC, Meade KG, McEvoy AN, Lillis L, Murphy EP, MacHugh DE, Baird AW (2007). "Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells". Vet Immunol Immunopathol116 (1-2): 59–68. PMID17276517. doi:10.1016/j.vetimm.2006.12.008.; (c) Renard P, Zachary MD, Bougelet C, Mirault ME, Haegeman G, Remacle J, Raes M (1997). "Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation". Biochem Pharmacol53 (2): 149–160. PMID9037247.; (d) Qin H, Wilson CA, Lee SJ, Zhao X, Benveniste EN (2005). "LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia". Blood106 (9): 3114–3122. PMC1895321. PMID16020513. doi:10.1182/blood-2005-02-0759.; (e) Takemoto Y, Yoshiyama M, Takeuchi K, Omura T, Komatsu R, Izumi Y, Kim S, Yoshikawa J (1999). "Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenol-induced cardiac remodeling". J Mol Cell Cardiol31 (11): 2017–2030. PMID10591028. doi:10.1006/jmcc.1999.1033.; (f) Hargrave BY, Tiangco DA, Lattanzio FA, Beebe SJ (2003). "Cocaine, not morphine, causes the generation of reactive oxygen species and activation of NF-kappaB in transiently cotransfected heart cells". Cardiovasc Toxicol3 (2): 141–151. PMID14501032. doi:10.1385/CT:3:2:141.; (g) Basu S, Rosenzweig KR, Youmell M, Price BD (1998). "The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage". Biochem Biophys Res Commun247 (1): 79–83. PMID9636658. doi:10.1006/bbrc.1998.8741.
Doyle SL, O'Neill LA (2006). "Toll-like receptors: from the discovery of NFκB to new insights into transcriptional regulations in innate immunity". Biochem. Pharmacol.72 (9): 1102–13. PMID16930560. doi:10.1016/j.bcp.2006.07.010.
Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K, Siebenlist U (1992). "The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition". Nature359 (6393): 339–42. PMID1406939. doi:10.1038/359339a0.
Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (1993). "The oncoprotein Bcl-3 directly transactivates through κ B motifs via association with DNA-binding p50B homodimers". Cell72 (5): 729–39. PMID8453667. doi:10.1016/0092-8674(93)90401-B.
Nelson DE, Ihekwaba AE, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB, White MR (2004). "Oscillations in NF-κB signaling control the dynamics of gene expression". Science306 (5696): 704–8. PMID15499023. doi:10.1126/science.1099962.
Adkins I, Schulz S, Borgmann S, Autenrieth IB, Gröbner S (2008). "Differential roles of Yersinia outer protein P-mediated inhibition of nuclear factor-κB in the induction of cell death in dendritic cells and macrophages". J. Med. Microbiol.57 (Pt 2): 139–44. PMID18201977. doi:10.1099/jmm.0.47437-0.
Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M (2004). "Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers". EMBO J23 (21): 4202–10. PMID11547050. doi:10.1038/sj.emboj.7600391.
Livolsi A, Busuttil V, Imbert V, Abraham RT, Peyron JF (2001). "Tyrosine phosphorylation-dependent activation of NF-κB. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases". Eur. J. Biochem.268 (5): 1508–15. PMID11231305. doi:10.1046/j.1432-1327.2001.02028.x.
Wang J, Fu XQ, Lei WL, Wang T, Sheng AL, Luo ZG (2010). "Nuclear factor kappaB controls acetylcholine receptor clustering at the neuromuscular junction". J. Neurosci.30 (33): 11104–13. PMID20720118. doi:10.1523/JNEUROSCI.2118-10.2010.
Boersma MC, Dresselhaus EC, De Biase LM, Mihalas AB, Bergles DE, Meffert MK (2011). "A Requirement for Nuclear Factor-κB in Developmental and Plasticity-Associated Synaptogenesis". J. Neurosci.31 (14): 5414–25. PMID21471377. doi:10.1523/JNEUROSCI.2456-10.2011.
Gutierrez H, Hale VA, Dolcet X, Davies A (2005). "NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS". Development132 (7): 1713–26. PMID15743881. doi:10.1242/dev.01702.
Borges K, Dingledine R (2001). "Functional organization of the GluR1 glutamate receptor promoter". J. Biol. Chem.276 (28): 25929–38. PMID11340067. doi:10.1074/jbc.M009105200.
Yu Z, Cheng G, Wen X, Wu GD, Lee WT, Pleasure D (2002). "Tumor necrosis factor alpha increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit GluR1 via an acid sphingomyelinase- and NF-kappaB-dependent mechanism". Neurobiol. Dis.11 (1): 199–213. PMID12460558. doi:10.1006/nbdi.2002.0530.
Richter M, Suau P, Ponte I (2002). "Sequence and analysis of the 5' flanking and 5' untranslated regions of the rat N-methyl-D-aspartate receptor 2A gene". Gene295 (1): 135–42. PMID12242020. doi:10.1016/S0378-1119(02)00833-8.
Begni S, Moraschi S, Bignotti S, Fumagalli F, Rillosi L, Perez J, Gennarelli M (2003). "Association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia". Biol. Psychiatry53 (7): 617–9. PMID12679240. doi:10.1016/S0006-3223(02)01783-3.
Zaheer A, Yorek MA, Lim R (2001). "Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion". Neurochem. Res.26 (12): 1293–9. PMID11885780. doi:10.1023/A:1014241300179.
Qiu J, Hu X, Nesic O, Grafe MR, Rassin DK, Wood TG, Perez-Polo JR (2004). "Effects of NF-kappaB oligonucleotide "decoys" on gene expression in P7 rat hippocampus after hypoxia/ischemia". J. Neurosci. Res.77 (1): 108–18. PMID15197744. doi:10.1002/jnr.20156.
Escárcega RO, Fuentes-Alexandro S, García-Carrasco M, Gatica A, Zamora A (2007). "The transcription factor nuclear factor-κB and cancer". Clinical Oncology (Royal College of Radiologists (Great Britain))19 (2): 154–61. PMID17355113. doi:10.1016/j.clon.2006.11.013.
Venuraju SM, Yerramasu A, Corder R, Lahiri A (2010). "Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity". J. Am. Coll. Cardiol.55 (19): 2049–61. PMID20447527. doi:10.1016/j.jacc.2010.03.013.
Song XQ, Lv LX, Li WQ, Hao YH, Zhao JP (2009). "The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia". Biol. Psychiatry65 (6): 481–8. PMID19058794. doi:10.1016/j.biopsych.2008.10.018.
Karin M (2008). "The IκB kinase - a bridge between inflammation and cancer". Cell Res.18 (3): 334–42. PMID18301380. doi:10.1038/cr.2008.30.
Mantovani A, Marchesi F, Portal C, Allavena P, Sica A (2008). "Linking inflammation reactions to cancer: novel targets for therapeutic strategies". Adv. Exp. Med. Biol.610: 112–27. PMID18593019. doi:10.1007/978-0-387-73898-7_9.
Paur I, Balstad TR, Kolberg M, Pedersen MK, Austenaa LM, Jacobs DR, Blomhoff R (2010). "Extract of oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice". Cancer Prev Res (Phila)3 (5): 653–63. PMID20424131. doi:10.1158/1940-6207.CAPR-09-0089.
Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development". Leukemia16 (6): 1053–68. PMID12040437. doi:10.1038/sj.leu.2402482.
Cvek B, Dvorak Z (2007). "Targeting of nuclear factor-κB and proteasome by dithiocarbamate complexes with metals". Curr. Pharm. Des.13 (30): 3155–67. PMID17979756. doi:10.2174/138161207782110390.
espacenet.com
worldwide.espacenet.com
US patent 6410516, Baltimore D; Sen R; Sharp PA; Singh H; Staudt L; Lebowitz JH; Baldwin Jr AS; Clerc RG; Corcoran LM; Baeuerle PA; Lenardo MJ; Fan C-M; Maniatis TPD, "Nuclear factors associated with transcriptional regulation", issued 2002-06-25. US patent reference | number = 6410516 | y = 2002 | m = 06 | d = 25 [1]
Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D (2003). "NF-kappa B functions in synaptic signaling and behavior". Nat. Neurosci.6 (10): 1072–8. PMID12947408. doi:10.1038/nn1110.
Levenson JM, Choi S, Lee SY, Cao YA, Ahn HJ, Worley KC, Pizzi M, Liou HC, Sweatt JD (2004). "A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel". J. Neurosci.24 (16): 3933–43. PMID15102909. doi:10.1523/JNEUROSCI.5646-03.2004.
Freudenthal R, Locatelli F, Hermitte G, Maldonado H, Lafourcade C, Delorenzi A, Romano A (1998). "Kappa-B like DNA-binding activity is enhanced after spaced training that induces long-term memory in the crab Chasmagnathus". Neurosci. Lett.242 (3): 143–6. PMID9530926. doi:10.1016/S0304-3940(98)00059-7.
Merlo E, Freudenthal R, Romano A (2002). "The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus". Neuroscience112 (1): 161–72. PMID12044481. doi:10.1016/S0306-4522(02)00049-0.
Sen R, Baltimore D (1986). "Multiple nuclear factors interact with the immunoglobulin enhancer sequences". Cell46 (5): 705–16. PMID3091258. doi:10.1016/0092-8674(86)90346-6.
Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M (2001). "Activation by IKKalpha of a second, evolutionary conserved, NF-κB signaling pathway". Science293 (5534): 1495–9. PMID11520989. doi:10.1126/science.1062677.
(a) Chandel NS, Trzyna WC, McClintock DS, Schumacker PT (2000). "Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin". J Immunol165 (2): 1013–1021. PMID10878378.; (b) Fitzgerald DC, Meade KG, McEvoy AN, Lillis L, Murphy EP, MacHugh DE, Baird AW (2007). "Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells". Vet Immunol Immunopathol116 (1-2): 59–68. PMID17276517. doi:10.1016/j.vetimm.2006.12.008.; (c) Renard P, Zachary MD, Bougelet C, Mirault ME, Haegeman G, Remacle J, Raes M (1997). "Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation". Biochem Pharmacol53 (2): 149–160. PMID9037247.; (d) Qin H, Wilson CA, Lee SJ, Zhao X, Benveniste EN (2005). "LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia". Blood106 (9): 3114–3122. PMC1895321. PMID16020513. doi:10.1182/blood-2005-02-0759.; (e) Takemoto Y, Yoshiyama M, Takeuchi K, Omura T, Komatsu R, Izumi Y, Kim S, Yoshikawa J (1999). "Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenol-induced cardiac remodeling". J Mol Cell Cardiol31 (11): 2017–2030. PMID10591028. doi:10.1006/jmcc.1999.1033.; (f) Hargrave BY, Tiangco DA, Lattanzio FA, Beebe SJ (2003). "Cocaine, not morphine, causes the generation of reactive oxygen species and activation of NF-kappaB in transiently cotransfected heart cells". Cardiovasc Toxicol3 (2): 141–151. PMID14501032. doi:10.1385/CT:3:2:141.; (g) Basu S, Rosenzweig KR, Youmell M, Price BD (1998). "The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage". Biochem Biophys Res Commun247 (1): 79–83. PMID9636658. doi:10.1006/bbrc.1998.8741.
Doyle SL, O'Neill LA (2006). "Toll-like receptors: from the discovery of NFκB to new insights into transcriptional regulations in innate immunity". Biochem. Pharmacol.72 (9): 1102–13. PMID16930560. doi:10.1016/j.bcp.2006.07.010.
Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K, Siebenlist U (1992). "The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-κB-mediated inhibition". Nature359 (6393): 339–42. PMID1406939. doi:10.1038/359339a0.
Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (1993). "The oncoprotein Bcl-3 directly transactivates through κ B motifs via association with DNA-binding p50B homodimers". Cell72 (5): 729–39. PMID8453667. doi:10.1016/0092-8674(93)90401-B.
Dobrzanski P, Ryseck RP, Bravo R (1995). "Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100". Oncogene10 (5): 1003–7. PMID7898917.
Nelson DE, Ihekwaba AE, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB, White MR (2004). "Oscillations in NF-κB signaling control the dynamics of gene expression". Science306 (5696): 704–8. PMID15499023. doi:10.1126/science.1099962.
Adkins I, Schulz S, Borgmann S, Autenrieth IB, Gröbner S (2008). "Differential roles of Yersinia outer protein P-mediated inhibition of nuclear factor-κB in the induction of cell death in dendritic cells and macrophages". J. Med. Microbiol.57 (Pt 2): 139–44. PMID18201977. doi:10.1099/jmm.0.47437-0.
Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M (2004). "Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers". EMBO J23 (21): 4202–10. PMID11547050. doi:10.1038/sj.emboj.7600391.
Livolsi A, Busuttil V, Imbert V, Abraham RT, Peyron JF (2001). "Tyrosine phosphorylation-dependent activation of NF-κB. Requirement for p56 LCK and ZAP-70 protein tyrosine kinases". Eur. J. Biochem.268 (5): 1508–15. PMID11231305. doi:10.1046/j.1432-1327.2001.02028.x.
Wang J, Fu XQ, Lei WL, Wang T, Sheng AL, Luo ZG (2010). "Nuclear factor kappaB controls acetylcholine receptor clustering at the neuromuscular junction". J. Neurosci.30 (33): 11104–13. PMID20720118. doi:10.1523/JNEUROSCI.2118-10.2010.
Boersma MC, Dresselhaus EC, De Biase LM, Mihalas AB, Bergles DE, Meffert MK (2011). "A Requirement for Nuclear Factor-κB in Developmental and Plasticity-Associated Synaptogenesis". J. Neurosci.31 (14): 5414–25. PMID21471377. doi:10.1523/JNEUROSCI.2456-10.2011.
Gutierrez H, Hale VA, Dolcet X, Davies A (2005). "NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS". Development132 (7): 1713–26. PMID15743881. doi:10.1242/dev.01702.
Borges K, Dingledine R (2001). "Functional organization of the GluR1 glutamate receptor promoter". J. Biol. Chem.276 (28): 25929–38. PMID11340067. doi:10.1074/jbc.M009105200.
Yu Z, Cheng G, Wen X, Wu GD, Lee WT, Pleasure D (2002). "Tumor necrosis factor alpha increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit GluR1 via an acid sphingomyelinase- and NF-kappaB-dependent mechanism". Neurobiol. Dis.11 (1): 199–213. PMID12460558. doi:10.1006/nbdi.2002.0530.
Richter M, Suau P, Ponte I (2002). "Sequence and analysis of the 5' flanking and 5' untranslated regions of the rat N-methyl-D-aspartate receptor 2A gene". Gene295 (1): 135–42. PMID12242020. doi:10.1016/S0378-1119(02)00833-8.
Begni S, Moraschi S, Bignotti S, Fumagalli F, Rillosi L, Perez J, Gennarelli M (2003). "Association between the G1001C polymorphism in the GRIN1 gene promoter region and schizophrenia". Biol. Psychiatry53 (7): 617–9. PMID12679240. doi:10.1016/S0006-3223(02)01783-3.
Zaheer A, Yorek MA, Lim R (2001). "Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion". Neurochem. Res.26 (12): 1293–9. PMID11885780. doi:10.1023/A:1014241300179.
Qiu J, Hu X, Nesic O, Grafe MR, Rassin DK, Wood TG, Perez-Polo JR (2004). "Effects of NF-kappaB oligonucleotide "decoys" on gene expression in P7 rat hippocampus after hypoxia/ischemia". J. Neurosci. Res.77 (1): 108–18. PMID15197744. doi:10.1002/jnr.20156.
Escárcega RO, Fuentes-Alexandro S, García-Carrasco M, Gatica A, Zamora A (2007). "The transcription factor nuclear factor-κB and cancer". Clinical Oncology (Royal College of Radiologists (Great Britain))19 (2): 154–61. PMID17355113. doi:10.1016/j.clon.2006.11.013.
Monaco C, Andreakos E, Kiriakidis S, Mauri C, Bicknell C, Foxwell B, Cheshire N, Paleolog E, Feldmann M. Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5634-9. Epub 2004 Apr 2. PubMed PMID 15064395Link to paper;; PubMed Central PMCID: PMC397455.
Venuraju SM, Yerramasu A, Corder R, Lahiri A (2010). "Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity". J. Am. Coll. Cardiol.55 (19): 2049–61. PMID20447527. doi:10.1016/j.jacc.2010.03.013.
Song XQ, Lv LX, Li WQ, Hao YH, Zhao JP (2009). "The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia". Biol. Psychiatry65 (6): 481–8. PMID19058794. doi:10.1016/j.biopsych.2008.10.018.
Karin M (2008). "The IκB kinase - a bridge between inflammation and cancer". Cell Res.18 (3): 334–42. PMID18301380. doi:10.1038/cr.2008.30.
Mantovani A, Marchesi F, Portal C, Allavena P, Sica A (2008). "Linking inflammation reactions to cancer: novel targets for therapeutic strategies". Adv. Exp. Med. Biol.610: 112–27. PMID18593019. doi:10.1007/978-0-387-73898-7_9.
Paur I, Balstad TR, Kolberg M, Pedersen MK, Austenaa LM, Jacobs DR, Blomhoff R (2010). "Extract of oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice". Cancer Prev Res (Phila)3 (5): 653–63. PMID20424131. doi:10.1158/1940-6207.CAPR-09-0089.
Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development". Leukemia16 (6): 1053–68. PMID12040437. doi:10.1038/sj.leu.2402482.
Cvek B, Dvorak Z (2007). "Targeting of nuclear factor-κB and proteasome by dithiocarbamate complexes with metals". Curr. Pharm. Des.13 (30): 3155–67. PMID17979756. doi:10.2174/138161207782110390.
pnas.org
Monaco C, Andreakos E, Kiriakidis S, Mauri C, Bicknell C, Foxwell B, Cheshire N, Paleolog E, Feldmann M. Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis. Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5634-9. Epub 2004 Apr 2. PubMed PMID 15064395Link to paper;; PubMed Central PMCID: PMC397455.