Epigenética do comportamento (Portuguese Wikipedia)
Analysis of information sources in references of the Wikipedia article "Epigenética do comportamento" in Portuguese language version.
refsWebsite
Global rank
Portuguese rank
18th place
51st place
622nd place
10th place
5th place
5th place
low place
low place
4,679th place
3,123rd place
149th place
155th place
3,867th place
2,241st place
annualreviews.org
- O'Donnell, Kieran J.; Meaney, Michael J. (7 de maio de 2020). «Epigenetics, Development, and Psychopathology». Annual Review of Clinical Psychology (em inglês) (1): 327–350. ISSN 1548-5943. doi:10.1146/annurev-clinpsy-050718-095530. Consultado em 10 de fevereiro de 2021
doi.org
dx.doi.org
- Miller G (julho de 2010). «Epigenetics. The seductive allure of behavioral epigenetics». Science. 329: 24–7. Bibcode:2010Sci...329...24M. PMID 20595592. doi:10.1126/science.329.5987.24
- Powledge T (2011). «Behavioral epigenetics: How nurture shapes nature». BioScience. 61: 588–592. doi:10.1525/bio.2011.61.8.4
- Champagne FA, Mashoodh R (2012). «Genes in context: Gene-environment interplay and the origins of individual differences in behaviour». Current Directions in Psychological Science. 18: 127–131. doi:10.1111/j.1467-8721.2009.01622.x
- Zhang TY, Meaney MJ (2010). «Epigenetics and the environmental regulation of the genome and its function». Annual Review of Psychology. 61: 439–66, C1-3. PMID 19958180. doi:10.1146/annurev.psych.60.110707.163625
- Bagot RC, Meaney MJ (agosto de 2010). «Epigenetics and the biological basis of gene x environment interactions». Journal of the American Academy of Child and Adolescent Psychiatry. 49: 752–71. PMID 20643310. doi:10.1016/j.jaac.2010.06.001
- Stuffrein-Roberts S, Joyce PR, Kennedy MA (fevereiro de 2008). «Role of epigenetics in mental disorders». The Australian and New Zealand Journal of Psychiatry. 42: 97–107. PMID 18197504. doi:10.1080/00048670701787495
- Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, Wang SC, Petronis A (março de 2008). «Epigenomic profiling reveals DNA-methylation changes associated with major psychosis». American Journal of Human Genetics. 82: 696–711. PMC 2427301. PMID 18319075. doi:10.1016/j.ajhg.2008.01.008
- Rana, Ajay Kumar (24 de janeiro de 2018). «Crime investigation through DNA methylation analysis: methods and applications in forensics». Egyptian Journal of Forensic Sciences. 8. doi:10.1186/s41935-018-0042-1
- Pennisi E (agosto de 2001). «Behind the scenes of gene expression». Science. 293: 1064–7. PMID 11498570. doi:10.1126/science.293.5532.1064
- Juliandi B, Abematsu M, Nakashima K (agosto de 2010). «Epigenetic regulation in neural stem cell differentiation». Development, Growth & Differentiation. 52: 493–504. PMID 20608952. doi:10.1111/j.1440-169X.2010.01175.x
- Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H (novembro de 2010). «Epigenetic choreographers of neurogenesis in the adult mammalian brain». Nature Neuroscience. 13: 1338–44. PMC 3324277. PMID 20975758. doi:10.1038/nn.2672
- Sun J, Sun J, Ming GL, Song H (março de 2011). «Epigenetic regulation of neurogenesis in the adult mammalian brain». The European Journal of Neuroscience. 33: 1087–93. PMC 3076719. PMID 21395852. doi:10.1111/j.1460-9568.2011.07607.x
- Bird A (maio de 2007). «Perceptions of epigenetics». Nature. 447: 396–8. Bibcode:2007Natur.447..396B. PMID 17522671. doi:10.1038/nature05913
- Mehler MF (dezembro de 2008). «Epigenetic principles and mechanisms underlying nervous system functions in health and disease». Progress in Neurobiology. 86: 305–41. PMC 2636693. PMID 18940229. doi:10.1016/j.pneurobio.2008.10.001
- Maze I, Nestler EJ (janeiro de 2011). «The epigenetic landscape of addiction». Annals of the New York Academy of Sciences. 1216: 99–113. Bibcode:2011NYASA1216...99M. PMC 3071632. PMID 21272014. doi:10.1111/j.1749-6632.2010.05893.x
- Reik W (maio de 2007). «Stability and flexibility of epigenetic gene regulation in mammalian development». Nature. 447: 425–32. Bibcode:2007Natur.447..425R. PMID 17522676. doi:10.1038/nature05918
- Gottesman II, Hanson DR (2005). «Human development: biological and genetic processes». Annual Review of Psychology. 56: 263–86. PMID 15709936. doi:10.1146/annurev.psych.56.091103.070208
- Campbell IC, Mill J, Uher R, Schmidt U (janeiro de 2011). «Eating disorders, gene-environment interactions and epigenetics». Neuroscience and Biobehavioral Reviews. 35: 784–93. PMID 20888360. doi:10.1016/j.neubiorev.2010.09.012
- Goto T, Monk M (junho de 1998). «Regulation of X-chromosome inactivation in development in mice and humans». Microbiology and Molecular Biology Reviews. 62: 362–78. PMC 98919. PMID 9618446. doi:10.1128/MMBR.62.2.362-378.1998
- Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ (agosto de 2004). «Epigenetic programming by maternal behavior». Nature Neuroscience. 7: 847–54. PMID 15220929. doi:10.1038/nn1276
- Kaminsky Z, Petronis A, Wang SC, Levine B, Ghaffar O, Floden D, Feinstein A (fevereiro de 2008). «Epigenetics of personality traits: an illustrative study of identical twins discordant for risk-taking behavior». Twin Research and Human Genetics. 11: 1–11. PMID 18251670. doi:10.1375/twin.11.1.1
- Kaminsky Z, Petronis A, Wang SC, Levine B, Ghaffar O, Floden D, Feinstein A (fevereiro de 2008). «Epigenetics of personality traits: an illustrative study of identical twins discordant for risk-taking behavior». Twin Research and Human Genetics. 11: 1–11. PMID 18251670. doi:10.1375/twin.11.1.1
- Masterpasqua F (2009). «Psychology and epigenetics». Review of General Psychology. 13: 194–201. doi:10.1037/a0016301
- Szyf M, McGowan P, Meaney MJ (janeiro de 2008). «The social environment and the epigenome». Environmental and Molecular Mutagenesis. 49: 46–60. PMID 18095330. doi:10.1002/em.20357
- González-Pardo H, Pérez Álvarez M (fevereiro de 2013). «Epigenetics and its implications for Psychology». Psicothema. 25: 3–12. PMID 23336536. doi:10.7334/psicothema2012.327
- Schiele, Miriam A.; Gottschalk, Michael G.; Domschke, Katharina (1 de abril de 2020). «The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention». Clinical Psychology Review (em inglês) (101830). ISSN 0272-7358. doi:10.1016/j.cpr.2020.101830. Consultado em 10 de fevereiro de 2021
- Day JJ, Sweatt JD (novembro de 2010). «DNA methylation and memory formation». Nature Neuroscience. 13: 1319–23. PMC 3130618. PMID 20975755. doi:10.1038/nn.2666
- Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (maio de 2007). «Recovery of learning and memory is associated with chromatin remodelling». Nature. 447: 178–82. Bibcode:2007Natur.447..178F. PMID 17468743. doi:10.1038/nature05772
- Gupta S, Kim SY, Artis S, Molfese DL, Schumacher A, Sweatt JD, Paylor RE, Lubin FD (março de 2010). «Histone methylation regulates memory formation». The Journal of Neuroscience. 30: 3589–99. PMC 2859898. PMID 20219993. doi:10.1523/JNEUROSCI.3732-09.2010
- Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH (março de 2012). «An epigenetic blockade of cognitive functions in the neurodegenerating brain». Nature. 483: 222–6. Bibcode:2012Natur.483..222G. PMC 3498952. PMID 22388814. doi:10.1038/nature10849
- Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A (maio de 2010). «Altered histone acetylation is associated with age-dependent memory impairment in mice». Science. 328: 753–6. Bibcode:2010Sci...328..753P. PMID 20448184. doi:10.1126/science.1186088
- O'Donnell, Kieran J.; Meaney, Michael J. (7 de maio de 2020). «Epigenetics, Development, and Psychopathology». Annual Review of Clinical Psychology (em inglês) (1): 327–350. ISSN 1548-5943. doi:10.1146/annurev-clinpsy-050718-095530. Consultado em 10 de fevereiro de 2021
- Broussard JI (janeiro de 2012). «Co-transmission of dopamine and glutamate». The Journal of General Physiology. 139 (1): 93–96. PMC 3250102. PMID 22200950. doi:10.1085/jgp.201110659.
Coincident and convergent input often induces plasticity on a postsynaptic neuron. The NAc integrates processed information about the environment from basolateral amygdala, hippocampus, and prefrontal cortex (PFC), as well as projections from midbrain dopamine neurons. Previous studies have demonstrated how dopamine modulates this integrative process. For example, high frequency stimulation potentiates hippocampal inputs to the NAc while simultaneously depressing PFC synapses (Goto and Grace, 2005). The converse was also shown to be true; stimulation at PFC potentiates PFC–NAc synapses but depresses hippocampal–NAc synapses. In light of the new functional evidence of midbrain dopamine/glutamate co-transmission (references above), new experiments of NAc function will have to test whether midbrain glutamatergic inputs bias or filter either limbic or cortical inputs to guide goal-directed behavior.
- Cadet JL, Brannock C, Jayanthi S, Krasnova IN (2015). «Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat». Molecular Neurobiology. 51 (2): 696–717. PMC 4359351. PMID 24939695. doi:10.1007/s12035-014-8776-8.
Figure 1
- Robison AJ, Nestler EJ (novembro de 2011). «Transcriptional and epigenetic mechanisms of addiction». Nature Reviews Neuroscience. 12 (11): 623–637. PMC 3272277. PMID 21989194. doi:10.1038/nrn3111.
ΔFosB serves as one of the master control proteins governing this structural plasticity. ... ΔFosB also represses G9a expression, leading to reduced repressive histone methylation at the cdk5 gene. The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression.
Figure 4: Epigenetic basis of drug regulation of gene expression - Nestler EJ (dezembro de 2012). «Transcriptional mechanisms of drug addiction». Clinical Psychopharmacology and Neuroscience. 10 (3): 136–143. PMC 3569166. PMID 23430970. doi:10.9758/cpn.2012.10.3.136.
The 35-37 kD ΔFosB isoforms accumulate with chronic drug exposure due to their extraordinarily long half-lives. ... As a result of its stability, the ΔFosB protein persists in neurons for at least several weeks after cessation of drug exposure. ... ΔFosB overexpression in nucleus accumbens induces NFκB ... In contrast, the ability of ΔFosB to repress the c-Fos gene occurs in concert with the recruitment of a histone deacetylase and presumably several other repressive proteins such as a repressive histone methyltransferase
- Nestler EJ (outubro de 2008). «Transcriptional mechanisms of addiction: Role of ΔFosB». Philosophical Transactions of the Royal Society B: Biological Sciences. 363 (1507): 3245–3255. PMC 2607320. PMID 18640924. doi:10.1098/rstb.2008.0067.
Recent evidence has shown that ΔFosB also represses the c-fos gene that helps create the molecular switch—from the induction of several short-lived Fos family proteins after acute drug exposure to the predominant accumulation of ΔFosB after chronic drug exposure
- Wong CC, Mill J, Fernandes C (março de 2011). «Drugs and addiction: an introduction to epigenetics». Addiction. 106: 480–9. PMID 21205049. doi:10.1111/j.1360-0443.2010.03321.x
- Andersen SL, Teicher MH (abril de 2009). «Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse». Neuroscience and Biobehavioral Reviews. 33: 516–24. PMC 2688959. PMID 18938197. doi:10.1016/j.neubiorev.2008.09.009
- Renthal W, Nestler EJ (agosto de 2008). «Epigenetic mechanisms in drug addiction». Trends in Molecular Medicine. 14: 341–50. PMC 2753378. PMID 18635399. doi:10.1016/j.molmed.2008.06.004
- Naassila M (2011). «Abstracts of ESBRA 2011, European Society for Biomedical Research on Alcoholism. Vienna, Austria. September 4–7, 2011». Alcohol and Alcoholism. 46 Suppl 1: i1-63. PMID 21863600. doi:10.1093/alcalc/agr085
- Launay JM, Del Pino M, Chironi G, Callebert J, Peoc'h K, Mégnien JL, Mallet J, Simon A, Rendu F (2009). «Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation». PLOS ONE. 4: e7959. Bibcode:2009PLoSO...4.7959L. PMC 2775922. PMID 19956754. doi:10.1371/journal.pone.0007959
- Marlatt GA, Baer JS, Donovan DM, Kivlahan DR (1988). «Addictive behaviors: etiology and treatment». Annual Review of Psychology. 39: 223–52. PMID 3278676. doi:10.1146/annurev.ps.39.020188.001255
- Bönsch D, Lenz B, Reulbach U, Kornhuber J, Bleich S (dezembro de 2004). «Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism». Journal of Neural Transmission. 111: 1611–6. PMID 15565495. doi:10.1007/s00702-004-0232-x
- He F, Lidow IA, Lidow MS (2006). «Consequences of paternal cocaine exposure in mice». Neurotoxicology and Teratology. 28: 198–209. PMID 16458479. doi:10.1016/j.ntt.2005.12.003
- Raney TJ, Thornton LM, Berrettini W, Brandt H, Crawford S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, LaVia M, Mitchell J, Rotondo A, Strober M, Woodside DB, Kaye WH, Bulik CM (maio de 2008). «Influence of overanxious disorder of childhood on the expression of anorexia nervosa». The International Journal of Eating Disorders. 41: 326–32. PMID 18213688. doi:10.1002/eat.20508
- Abdolmaleky HM, Thiagalingam S, Wilcox M (2005). «Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope». American Journal of Pharmacogenomics. 5: 149–60. PMID 15952869. doi:10.2165/00129785-200505030-00002
- Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser ES (abril de 2001). «Advancing paternal age and the risk of schizophrenia». Archives of General Psychiatry. 58: 361–7. PMID 11296097. doi:10.1001/archpsyc.58.4.361
- Rutten BP, Mill J (novembro de 2009). «Epigenetic mediation of environmental influences in major psychotic disorders». Schizophrenia Bulletin. 35: 1045–56. PMC 2762629. PMID 19783603. doi:10.1093/schbul/sbp104
- Yauk C, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ, Berndt ML, Pogribny IP, Koturbash I, Williams A, Douglas GR, Kovalchuk O (janeiro de 2008). «Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location». Proceedings of the National Academy of Sciences of the United States of America. 105: 605–10. Bibcode:2008PNAS..105..605Y. PMC 2206583. PMID 18195365. doi:10.1073/pnas.0705896105
- McGowan PO, Kato T (janeiro de 2008). «Epigenetics in mood disorders». Environmental Health and Preventive Medicine. 13: 16–24. PMC 2698240. PMID 19568875. doi:10.1007/s12199-007-0002-0
- Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, Smith CL, Shafa R, Aeali B, Carnevale J, Pan H, Papageorgis P, Ponte JF, Sivaraman V, Tsuang MT, Thiagalingam S (novembro de 2006). «Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder». Human Molecular Genetics. 15: 3132–45. PMC 2799943. PMID 16984965. doi:10.1093/hmg/ddl253
- Dempster EL, Mill J, Craig IW, Collier DA (2006). «The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression». BMC Medical Genetics. 7. 10 páginas. PMC 1456954. PMID 16483362. doi:10.1186/1471-2350-7-10
- Massart R, Mongeau R, Lanfumey L (setembro de 2012). «Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression». Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2485–94. PMC 3405682. PMID 22826347. doi:10.1098/rstb.2012.0212
- Pariante CM, Lightman SL (setembro de 2008). «The HPA axis in major depression: classical theories and new developments». Trends in Neurosciences. 31: 464–8. PMID 18675469. doi:10.1016/j.tins.2008.06.006
- Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (abril de 2006). «Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action». Nature Neuroscience. 9: 519–25. PMID 16501568. doi:10.1038/nn1659
- Gray JD, Milner TA, McEwen BS (junho de 2013). «Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors». Neuroscience. 239: 214–27. PMC 3743657. PMID 22922121. doi:10.1016/j.neuroscience.2012.08.034
- Hunter RG (2012). «Epigenetic effects of stress and corticosteroids in the brain». Frontiers in Cellular Neuroscience. 6. 18 páginas. PMC 3329877. PMID 22529779. doi:10.3389/fncel.2012.00018
- Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC (novembro de 2008). «Epigenetics in the nervous system». The Journal of Neuroscience. 28: 11753–9. PMC 3844836. PMID 19005036. doi:10.1523/JNEUROSCI.3797-08.2008
- Philibert RA, Beach SR, Gunter TD, Brody GH, Madan A, Gerrard M (março de 2010). «The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood». American Journal of Medical Genetics Part B. 153B: 619–28. PMC 3694401. PMID 19777560. doi:10.1002/ajmg.b.31031
- Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A (julho de 2008). «The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies». American Journal of Medical Genetics Part B. 147B: 543–9. PMC 3643119. PMID 17987668. doi:10.1002/ajmg.b.30657
- Philibert RA, Gunter TD, Beach SR, Brody GH, Madan A (julho de 2008). «MAOA methylation is associated with nicotine and alcohol dependence in women». American Journal of Medical Genetics Part B. 147B: 565–70. PMC 3685146. PMID 18454435. doi:10.1002/ajmg.b.30778
- Bodnar RJ (dezembro de 2010). «Endogenous opiates and behavior: 2009». Peptides. 31: 2325–59. PMC 2693002. PMID 20875476. doi:10.1016/j.peptides.2010.09.016
- Mill J, Petronis A (outubro de 2008). «Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility». Journal of Child Psychology and Psychiatry, and Allied Disciplines. 49: 1020–30. PMID 18492038. doi:10.1111/j.1469-7610.2008.01909.x
- Gunter TD, Vaughn MG, Philibert RA (2010). «Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature». Behavioral Sciences & the Law. 28: 148–73. PMID 20422643. doi:10.1002/bsl.923
- McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ (março de 2009). «Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse». Nature Neuroscience. 12: 342–8. PMC 2944040. PMID 19234457. doi:10.1038/nn.2270
- Herb BR, Wolschin F, Hansen KD, Aryee MJ, Langmead B, Irizarry R, Amdam GV, Feinberg AP (outubro de 2012). «Reversible switching between epigenetic states in honeybee behavioral subcastes». Nature Neuroscience. 15: 1371–3. PMC 3518384. PMID 22983211. doi:10.1038/nn.3218
- Kucharski R, Maleszka J, Foret S, Maleszka R (março de 2008). «Nutritional control of reproductive status in honeybees via DNA methylation». Science. 319: 1827–30. Bibcode:2008Sci...319.1827K. PMID 18339900. doi:10.1126/science.1153069
- Li-Byarlay H, Li Y, Stroud H, Feng S, Newman TC, Kaneda M, Hou KK, Worley KC, Elsik CG, Wickline SA, Jacobsen SE, Ma J, Robinson GE (julho de 2013). «RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee». Proceedings of the National Academy of Sciences of the United States of America. 110: 12750–5. Bibcode:2013PNAS..11012750L. PMC 3732956. PMID 23852726. doi:10.1073/pnas.1310735110
- Albert PR (novembro de 2010). «Epigenetics in mental illness: hope or hype?». Journal of Psychiatry & Neuroscience. 35: 366–8. PMC 2964366. PMID 20964959. doi:10.1503/jpn.100148
- Kalant H (maio de 2010). «What neurobiology cannot tell us about addiction». Addiction. 105: 780–9. PMID 19919596. doi:10.1111/j.1360-0443.2009.02739.x
- Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, Murray RM, Mill J (dezembro de 2011). «Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder». Human Molecular Genetics. 20: 4786–96. PMC 3221539. PMID 21908516. doi:10.1093/hmg/ddr416
frontiersin.org
journal.frontiersin.org
- Schechter DS, Moser DA, Giacobino A, Stenz L, Gex-Fabry M, Adouan W, Cordero MI, Suardi F, Manini A, Sancho-Rossignol A, Merminod G, Aue T, Ansermet F, Dayer AG, Rusconi-Serpa S. (epub maio de 29, 2015) Methylation of NR3C1 is related to maternal PTSD, parenting stress and maternal medial prefrontal cortical activity in response to child separation among mothers with histories of violence exposure. Frontiers in Psychology. http://journal.frontiersin.org/article/10.3389/fpsyg.2015.00690/abstract
genome.jp
- Kanehisa Laboratories (10 de outubro de 2014). «Amphetamine – Homo sapiens (human)». KEGG Pathway. Consultado em 31 de outubro de 2014.
Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefrontal cortex (mPFC), projection areas of mesocorticolimbic DA neurons and key components of the "brain reward circuit". Amphetamine achieves this elevation in extracellular levels of DA by promoting efflux from synaptic terminals. ... Chronic exposure to amphetamine induces a unique transcription factor delta FosB, which plays an essential role in long-term adaptive changes in the brain.
google.com.br
books.google.com.br
- Cloninger, C. Robert (20 de fevereiro de 2020). «Genetics of personality disorders». In: Geddes, John R.; Andreasen, Nancy C. New Oxford Textbook of Psychiatry (em inglês). [S.l.]: Oxford University Press
- Depue, Richard A.; Fu, Yu (1 de outubro de 2012). «Neurobiology and Neurochemistry of Temperament in Adults». In: Zentner, Marcel; Shiner, Rebecca L. Handbook of Temperament (em inglês). [S.l.]: Guilford Press
- Cloninger, C. Robert (2 de abril de 2007). «Genetics». In: Oldham, John M.; Skodol, Andrew E.; Bender, Donna S. The American Psychiatric Publishing Textbook of Personality Disorders (em inglês). [S.l.]: American Psychiatric Pub
- Fries, Gabriel R. (2020). «Genética e Epigenética dos Transtornos Psiquiátricos». In: Quevedo, João; Izquierdo, Ivan. Neurobiologia dos Transtornos Psiquiátricos. [S.l.]: Artmed Editora
- Brown, Mindy; Conradt, Elizabeth; Crowell, Sheila E. (2020). «Epigenetic Foundations of Emotional Dysregulation». In: Beauchaine, Theodore P.; Crowell, Sheila Elizabeth. The Oxford Handbook of Emotion Dysregulation (em inglês). [S.l.]: Oxford University Press
- Provenzi, Livio; Montirosso, Rosario (12 de novembro de 2020). Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions (em inglês). [S.l.]: Academic Press
harvard.edu
ui.adsabs.harvard.edu
- Miller G (julho de 2010). «Epigenetics. The seductive allure of behavioral epigenetics». Science. 329: 24–7. Bibcode:2010Sci...329...24M. PMID 20595592. doi:10.1126/science.329.5987.24
- Bird A (maio de 2007). «Perceptions of epigenetics». Nature. 447: 396–8. Bibcode:2007Natur.447..396B. PMID 17522671. doi:10.1038/nature05913
- Maze I, Nestler EJ (janeiro de 2011). «The epigenetic landscape of addiction». Annals of the New York Academy of Sciences. 1216: 99–113. Bibcode:2011NYASA1216...99M. PMC 3071632. PMID 21272014. doi:10.1111/j.1749-6632.2010.05893.x
- Reik W (maio de 2007). «Stability and flexibility of epigenetic gene regulation in mammalian development». Nature. 447: 425–32. Bibcode:2007Natur.447..425R. PMID 17522676. doi:10.1038/nature05918
- Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (maio de 2007). «Recovery of learning and memory is associated with chromatin remodelling». Nature. 447: 178–82. Bibcode:2007Natur.447..178F. PMID 17468743. doi:10.1038/nature05772
- Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH (março de 2012). «An epigenetic blockade of cognitive functions in the neurodegenerating brain». Nature. 483: 222–6. Bibcode:2012Natur.483..222G. PMC 3498952. PMID 22388814. doi:10.1038/nature10849
- Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A (maio de 2010). «Altered histone acetylation is associated with age-dependent memory impairment in mice». Science. 328: 753–6. Bibcode:2010Sci...328..753P. PMID 20448184. doi:10.1126/science.1186088
- Launay JM, Del Pino M, Chironi G, Callebert J, Peoc'h K, Mégnien JL, Mallet J, Simon A, Rendu F (2009). «Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation». PLOS ONE. 4: e7959. Bibcode:2009PLoSO...4.7959L. PMC 2775922. PMID 19956754. doi:10.1371/journal.pone.0007959
- Yauk C, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ, Berndt ML, Pogribny IP, Koturbash I, Williams A, Douglas GR, Kovalchuk O (janeiro de 2008). «Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location». Proceedings of the National Academy of Sciences of the United States of America. 105: 605–10. Bibcode:2008PNAS..105..605Y. PMC 2206583. PMID 18195365. doi:10.1073/pnas.0705896105
- Kucharski R, Maleszka J, Foret S, Maleszka R (março de 2008). «Nutritional control of reproductive status in honeybees via DNA methylation». Science. 319: 1827–30. Bibcode:2008Sci...319.1827K. PMID 18339900. doi:10.1126/science.1153069
- Li-Byarlay H, Li Y, Stroud H, Feng S, Newman TC, Kaneda M, Hou KK, Worley KC, Elsik CG, Wickline SA, Jacobsen SE, Ma J, Robinson GE (julho de 2013). «RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee». Proceedings of the National Academy of Sciences of the United States of America. 110: 12750–5. Bibcode:2013PNAS..11012750L. PMC 3732956. PMID 23852726. doi:10.1073/pnas.1310735110
nih.gov
ncbi.nlm.nih.gov
- Miller G (julho de 2010). «Epigenetics. The seductive allure of behavioral epigenetics». Science. 329: 24–7. Bibcode:2010Sci...329...24M. PMID 20595592. doi:10.1126/science.329.5987.24
- Zhang TY, Meaney MJ (2010). «Epigenetics and the environmental regulation of the genome and its function». Annual Review of Psychology. 61: 439–66, C1-3. PMID 19958180. doi:10.1146/annurev.psych.60.110707.163625
- Bagot RC, Meaney MJ (agosto de 2010). «Epigenetics and the biological basis of gene x environment interactions». Journal of the American Academy of Child and Adolescent Psychiatry. 49: 752–71. PMID 20643310. doi:10.1016/j.jaac.2010.06.001
- Stuffrein-Roberts S, Joyce PR, Kennedy MA (fevereiro de 2008). «Role of epigenetics in mental disorders». The Australian and New Zealand Journal of Psychiatry. 42: 97–107. PMID 18197504. doi:10.1080/00048670701787495
- Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L, Jia P, Assadzadeh A, Flanagan J, Schumacher A, Wang SC, Petronis A (março de 2008). «Epigenomic profiling reveals DNA-methylation changes associated with major psychosis». American Journal of Human Genetics. 82: 696–711. PMC 2427301. PMID 18319075. doi:10.1016/j.ajhg.2008.01.008
- Pennisi E (agosto de 2001). «Behind the scenes of gene expression». Science. 293: 1064–7. PMID 11498570. doi:10.1126/science.293.5532.1064
- Juliandi B, Abematsu M, Nakashima K (agosto de 2010). «Epigenetic regulation in neural stem cell differentiation». Development, Growth & Differentiation. 52: 493–504. PMID 20608952. doi:10.1111/j.1440-169X.2010.01175.x
- Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H (novembro de 2010). «Epigenetic choreographers of neurogenesis in the adult mammalian brain». Nature Neuroscience. 13: 1338–44. PMC 3324277. PMID 20975758. doi:10.1038/nn.2672
- Sun J, Sun J, Ming GL, Song H (março de 2011). «Epigenetic regulation of neurogenesis in the adult mammalian brain». The European Journal of Neuroscience. 33: 1087–93. PMC 3076719. PMID 21395852. doi:10.1111/j.1460-9568.2011.07607.x
- Bird A (maio de 2007). «Perceptions of epigenetics». Nature. 447: 396–8. Bibcode:2007Natur.447..396B. PMID 17522671. doi:10.1038/nature05913
- Mehler MF (dezembro de 2008). «Epigenetic principles and mechanisms underlying nervous system functions in health and disease». Progress in Neurobiology. 86: 305–41. PMC 2636693. PMID 18940229. doi:10.1016/j.pneurobio.2008.10.001
- Maze I, Nestler EJ (janeiro de 2011). «The epigenetic landscape of addiction». Annals of the New York Academy of Sciences. 1216: 99–113. Bibcode:2011NYASA1216...99M. PMC 3071632. PMID 21272014. doi:10.1111/j.1749-6632.2010.05893.x
- Reik W (maio de 2007). «Stability and flexibility of epigenetic gene regulation in mammalian development». Nature. 447: 425–32. Bibcode:2007Natur.447..425R. PMID 17522676. doi:10.1038/nature05918
- Gottesman II, Hanson DR (2005). «Human development: biological and genetic processes». Annual Review of Psychology. 56: 263–86. PMID 15709936. doi:10.1146/annurev.psych.56.091103.070208
- Campbell IC, Mill J, Uher R, Schmidt U (janeiro de 2011). «Eating disorders, gene-environment interactions and epigenetics». Neuroscience and Biobehavioral Reviews. 35: 784–93. PMID 20888360. doi:10.1016/j.neubiorev.2010.09.012
- Goto T, Monk M (junho de 1998). «Regulation of X-chromosome inactivation in development in mice and humans». Microbiology and Molecular Biology Reviews. 62: 362–78. PMC 98919. PMID 9618446. doi:10.1128/MMBR.62.2.362-378.1998
- Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ (agosto de 2004). «Epigenetic programming by maternal behavior». Nature Neuroscience. 7: 847–54. PMID 15220929. doi:10.1038/nn1276
- Kaminsky Z, Petronis A, Wang SC, Levine B, Ghaffar O, Floden D, Feinstein A (fevereiro de 2008). «Epigenetics of personality traits: an illustrative study of identical twins discordant for risk-taking behavior». Twin Research and Human Genetics. 11: 1–11. PMID 18251670. doi:10.1375/twin.11.1.1
- Kaminsky Z, Petronis A, Wang SC, Levine B, Ghaffar O, Floden D, Feinstein A (fevereiro de 2008). «Epigenetics of personality traits: an illustrative study of identical twins discordant for risk-taking behavior». Twin Research and Human Genetics. 11: 1–11. PMID 18251670. doi:10.1375/twin.11.1.1
- Szyf M, McGowan P, Meaney MJ (janeiro de 2008). «The social environment and the epigenome». Environmental and Molecular Mutagenesis. 49: 46–60. PMID 18095330. doi:10.1002/em.20357
- González-Pardo H, Pérez Álvarez M (fevereiro de 2013). «Epigenetics and its implications for Psychology». Psicothema. 25: 3–12. PMID 23336536. doi:10.7334/psicothema2012.327
- Day JJ, Sweatt JD (novembro de 2010). «DNA methylation and memory formation». Nature Neuroscience. 13: 1319–23. PMC 3130618. PMID 20975755. doi:10.1038/nn.2666
- Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH (maio de 2007). «Recovery of learning and memory is associated with chromatin remodelling». Nature. 447: 178–82. Bibcode:2007Natur.447..178F. PMID 17468743. doi:10.1038/nature05772
- Gupta S, Kim SY, Artis S, Molfese DL, Schumacher A, Sweatt JD, Paylor RE, Lubin FD (março de 2010). «Histone methylation regulates memory formation». The Journal of Neuroscience. 30: 3589–99. PMC 2859898. PMID 20219993. doi:10.1523/JNEUROSCI.3732-09.2010
- Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH (março de 2012). «An epigenetic blockade of cognitive functions in the neurodegenerating brain». Nature. 483: 222–6. Bibcode:2012Natur.483..222G. PMC 3498952. PMID 22388814. doi:10.1038/nature10849
- Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A (maio de 2010). «Altered histone acetylation is associated with age-dependent memory impairment in mice». Science. 328: 753–6. Bibcode:2010Sci...328..753P. PMID 20448184. doi:10.1126/science.1186088
- Renthal W, Nestler EJ (setembro de 2009). «Chromatin regulation in drug addiction and depression». Dialogues in Clinical Neuroscience. 11 (3): 257–268. PMC 2834246. PMID 19877494.
[Psychostimulants] increase cAMP levels in striatum, which activates protein kinase A (PKA) and leads to phosphorylation of its targets. This includes the cAMP response element binding protein (CREB), the phosphorylation of which induces its association with the histone acetyltransferase, CREB binding protein (CBP) to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response to psychostimulant exposure. ΔFosB is also upregulated by chronic psychostimulant treatments, and is known to activate certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic [signaling] from the prefrontal cortex to the NAc. Glutamatergic signaling elevates Ca2+ levels in NAc postsynaptic elements where it activates CaMK (calcium/calmodulin protein kinases) signaling, which, in addition to phosphorylating CREB, also phosphorylates HDAC5.
Figure 2: Psychostimulant-induced signaling events - Broussard JI (janeiro de 2012). «Co-transmission of dopamine and glutamate». The Journal of General Physiology. 139 (1): 93–96. PMC 3250102. PMID 22200950. doi:10.1085/jgp.201110659.
Coincident and convergent input often induces plasticity on a postsynaptic neuron. The NAc integrates processed information about the environment from basolateral amygdala, hippocampus, and prefrontal cortex (PFC), as well as projections from midbrain dopamine neurons. Previous studies have demonstrated how dopamine modulates this integrative process. For example, high frequency stimulation potentiates hippocampal inputs to the NAc while simultaneously depressing PFC synapses (Goto and Grace, 2005). The converse was also shown to be true; stimulation at PFC potentiates PFC–NAc synapses but depresses hippocampal–NAc synapses. In light of the new functional evidence of midbrain dopamine/glutamate co-transmission (references above), new experiments of NAc function will have to test whether midbrain glutamatergic inputs bias or filter either limbic or cortical inputs to guide goal-directed behavior.
- Cadet JL, Brannock C, Jayanthi S, Krasnova IN (2015). «Transcriptional and epigenetic substrates of methamphetamine addiction and withdrawal: evidence from a long-access self-administration model in the rat». Molecular Neurobiology. 51 (2): 696–717. PMC 4359351. PMID 24939695. doi:10.1007/s12035-014-8776-8.
Figure 1
- Robison AJ, Nestler EJ (novembro de 2011). «Transcriptional and epigenetic mechanisms of addiction». Nature Reviews Neuroscience. 12 (11): 623–637. PMC 3272277. PMID 21989194. doi:10.1038/nrn3111.
ΔFosB serves as one of the master control proteins governing this structural plasticity. ... ΔFosB also represses G9a expression, leading to reduced repressive histone methylation at the cdk5 gene. The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression.
Figure 4: Epigenetic basis of drug regulation of gene expression - Nestler EJ (dezembro de 2012). «Transcriptional mechanisms of drug addiction». Clinical Psychopharmacology and Neuroscience. 10 (3): 136–143. PMC 3569166. PMID 23430970. doi:10.9758/cpn.2012.10.3.136.
The 35-37 kD ΔFosB isoforms accumulate with chronic drug exposure due to their extraordinarily long half-lives. ... As a result of its stability, the ΔFosB protein persists in neurons for at least several weeks after cessation of drug exposure. ... ΔFosB overexpression in nucleus accumbens induces NFκB ... In contrast, the ability of ΔFosB to repress the c-Fos gene occurs in concert with the recruitment of a histone deacetylase and presumably several other repressive proteins such as a repressive histone methyltransferase
- Nestler EJ (outubro de 2008). «Transcriptional mechanisms of addiction: Role of ΔFosB». Philosophical Transactions of the Royal Society B: Biological Sciences. 363 (1507): 3245–3255. PMC 2607320. PMID 18640924. doi:10.1098/rstb.2008.0067.
Recent evidence has shown that ΔFosB also represses the c-fos gene that helps create the molecular switch—from the induction of several short-lived Fos family proteins after acute drug exposure to the predominant accumulation of ΔFosB after chronic drug exposure
- Wong CC, Mill J, Fernandes C (março de 2011). «Drugs and addiction: an introduction to epigenetics». Addiction. 106: 480–9. PMID 21205049. doi:10.1111/j.1360-0443.2010.03321.x
- Andersen SL, Teicher MH (abril de 2009). «Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse». Neuroscience and Biobehavioral Reviews. 33: 516–24. PMC 2688959. PMID 18938197. doi:10.1016/j.neubiorev.2008.09.009
- Renthal W, Nestler EJ (agosto de 2008). «Epigenetic mechanisms in drug addiction». Trends in Molecular Medicine. 14: 341–50. PMC 2753378. PMID 18635399. doi:10.1016/j.molmed.2008.06.004
- Naassila M (2011). «Abstracts of ESBRA 2011, European Society for Biomedical Research on Alcoholism. Vienna, Austria. September 4–7, 2011». Alcohol and Alcoholism. 46 Suppl 1: i1-63. PMID 21863600. doi:10.1093/alcalc/agr085
- Launay JM, Del Pino M, Chironi G, Callebert J, Peoc'h K, Mégnien JL, Mallet J, Simon A, Rendu F (2009). «Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation». PLOS ONE. 4: e7959. Bibcode:2009PLoSO...4.7959L. PMC 2775922. PMID 19956754. doi:10.1371/journal.pone.0007959
- Marlatt GA, Baer JS, Donovan DM, Kivlahan DR (1988). «Addictive behaviors: etiology and treatment». Annual Review of Psychology. 39: 223–52. PMID 3278676. doi:10.1146/annurev.ps.39.020188.001255
- Bönsch D, Lenz B, Reulbach U, Kornhuber J, Bleich S (dezembro de 2004). «Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism». Journal of Neural Transmission. 111: 1611–6. PMID 15565495. doi:10.1007/s00702-004-0232-x
- He F, Lidow IA, Lidow MS (2006). «Consequences of paternal cocaine exposure in mice». Neurotoxicology and Teratology. 28: 198–209. PMID 16458479. doi:10.1016/j.ntt.2005.12.003
- Raney TJ, Thornton LM, Berrettini W, Brandt H, Crawford S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, LaVia M, Mitchell J, Rotondo A, Strober M, Woodside DB, Kaye WH, Bulik CM (maio de 2008). «Influence of overanxious disorder of childhood on the expression of anorexia nervosa». The International Journal of Eating Disorders. 41: 326–32. PMID 18213688. doi:10.1002/eat.20508
- Abdolmaleky HM, Thiagalingam S, Wilcox M (2005). «Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope». American Journal of Pharmacogenomics. 5: 149–60. PMID 15952869. doi:10.2165/00129785-200505030-00002
- Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D, Susser ES (abril de 2001). «Advancing paternal age and the risk of schizophrenia». Archives of General Psychiatry. 58: 361–7. PMID 11296097. doi:10.1001/archpsyc.58.4.361
- Rutten BP, Mill J (novembro de 2009). «Epigenetic mediation of environmental influences in major psychotic disorders». Schizophrenia Bulletin. 35: 1045–56. PMC 2762629. PMID 19783603. doi:10.1093/schbul/sbp104
- Yauk C, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ, Berndt ML, Pogribny IP, Koturbash I, Williams A, Douglas GR, Kovalchuk O (janeiro de 2008). «Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location». Proceedings of the National Academy of Sciences of the United States of America. 105: 605–10. Bibcode:2008PNAS..105..605Y. PMC 2206583. PMID 18195365. doi:10.1073/pnas.0705896105
- McGowan PO, Kato T (janeiro de 2008). «Epigenetics in mood disorders». Environmental Health and Preventive Medicine. 13: 16–24. PMC 2698240. PMID 19568875. doi:10.1007/s12199-007-0002-0
- Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, Smith CL, Shafa R, Aeali B, Carnevale J, Pan H, Papageorgis P, Ponte JF, Sivaraman V, Tsuang MT, Thiagalingam S (novembro de 2006). «Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder». Human Molecular Genetics. 15: 3132–45. PMC 2799943. PMID 16984965. doi:10.1093/hmg/ddl253
- Dempster EL, Mill J, Craig IW, Collier DA (2006). «The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression». BMC Medical Genetics. 7. 10 páginas. PMC 1456954. PMID 16483362. doi:10.1186/1471-2350-7-10
- Massart R, Mongeau R, Lanfumey L (setembro de 2012). «Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression». Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2485–94. PMC 3405682. PMID 22826347. doi:10.1098/rstb.2012.0212
- Pariante CM, Lightman SL (setembro de 2008). «The HPA axis in major depression: classical theories and new developments». Trends in Neurosciences. 31: 464–8. PMID 18675469. doi:10.1016/j.tins.2008.06.006
- Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (abril de 2006). «Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action». Nature Neuroscience. 9: 519–25. PMID 16501568. doi:10.1038/nn1659
- Gray JD, Milner TA, McEwen BS (junho de 2013). «Dynamic plasticity: the role of glucocorticoids, brain-derived neurotrophic factor and other trophic factors». Neuroscience. 239: 214–27. PMC 3743657. PMID 22922121. doi:10.1016/j.neuroscience.2012.08.034
- Hunter RG (2012). «Epigenetic effects of stress and corticosteroids in the brain». Frontiers in Cellular Neuroscience. 6. 18 páginas. PMC 3329877. PMID 22529779. doi:10.3389/fncel.2012.00018
- Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC (novembro de 2008). «Epigenetics in the nervous system». The Journal of Neuroscience. 28: 11753–9. PMC 3844836. PMID 19005036. doi:10.1523/JNEUROSCI.3797-08.2008
- Philibert RA, Beach SR, Gunter TD, Brody GH, Madan A, Gerrard M (março de 2010). «The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood». American Journal of Medical Genetics Part B. 153B: 619–28. PMC 3694401. PMID 19777560. doi:10.1002/ajmg.b.31031
- Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A (julho de 2008). «The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies». American Journal of Medical Genetics Part B. 147B: 543–9. PMC 3643119. PMID 17987668. doi:10.1002/ajmg.b.30657
- Philibert RA, Gunter TD, Beach SR, Brody GH, Madan A (julho de 2008). «MAOA methylation is associated with nicotine and alcohol dependence in women». American Journal of Medical Genetics Part B. 147B: 565–70. PMC 3685146. PMID 18454435. doi:10.1002/ajmg.b.30778
- Bodnar RJ (dezembro de 2010). «Endogenous opiates and behavior: 2009». Peptides. 31: 2325–59. PMC 2693002. PMID 20875476. doi:10.1016/j.peptides.2010.09.016
- Mill J, Petronis A (outubro de 2008). «Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility». Journal of Child Psychology and Psychiatry, and Allied Disciplines. 49: 1020–30. PMID 18492038. doi:10.1111/j.1469-7610.2008.01909.x
- Gunter TD, Vaughn MG, Philibert RA (2010). «Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature». Behavioral Sciences & the Law. 28: 148–73. PMID 20422643. doi:10.1002/bsl.923
- McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ (março de 2009). «Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse». Nature Neuroscience. 12: 342–8. PMC 2944040. PMID 19234457. doi:10.1038/nn.2270
- Herb BR, Wolschin F, Hansen KD, Aryee MJ, Langmead B, Irizarry R, Amdam GV, Feinberg AP (outubro de 2012). «Reversible switching between epigenetic states in honeybee behavioral subcastes». Nature Neuroscience. 15: 1371–3. PMC 3518384. PMID 22983211. doi:10.1038/nn.3218
- Kucharski R, Maleszka J, Foret S, Maleszka R (março de 2008). «Nutritional control of reproductive status in honeybees via DNA methylation». Science. 319: 1827–30. Bibcode:2008Sci...319.1827K. PMID 18339900. doi:10.1126/science.1153069
- Li-Byarlay H, Li Y, Stroud H, Feng S, Newman TC, Kaneda M, Hou KK, Worley KC, Elsik CG, Wickline SA, Jacobsen SE, Ma J, Robinson GE (julho de 2013). «RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee». Proceedings of the National Academy of Sciences of the United States of America. 110: 12750–5. Bibcode:2013PNAS..11012750L. PMC 3732956. PMID 23852726. doi:10.1073/pnas.1310735110
- Albert PR (novembro de 2010). «Epigenetics in mental illness: hope or hype?». Journal of Psychiatry & Neuroscience. 35: 366–8. PMC 2964366. PMID 20964959. doi:10.1503/jpn.100148
- Kalant H (maio de 2010). «What neurobiology cannot tell us about addiction». Addiction. 105: 780–9. PMID 19919596. doi:10.1111/j.1360-0443.2009.02739.x
- Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, Murray RM, Mill J (dezembro de 2011). «Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder». Human Molecular Genetics. 20: 4786–96. PMC 3221539. PMID 21908516. doi:10.1093/hmg/ddr416
roadmapepigenomics.org
sciencedirect.com
- Schiele, Miriam A.; Gottschalk, Michael G.; Domschke, Katharina (1 de abril de 2020). «The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention». Clinical Psychology Review (em inglês) (101830). ISSN 0272-7358. doi:10.1016/j.cpr.2020.101830. Consultado em 10 de fevereiro de 2021
worldcat.org
- Schiele, Miriam A.; Gottschalk, Michael G.; Domschke, Katharina (1 de abril de 2020). «The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention». Clinical Psychology Review (em inglês) (101830). ISSN 0272-7358. doi:10.1016/j.cpr.2020.101830. Consultado em 10 de fevereiro de 2021
- O'Donnell, Kieran J.; Meaney, Michael J. (7 de maio de 2020). «Epigenetics, Development, and Psychopathology». Annual Review of Clinical Psychology (em inglês) (1): 327–350. ISSN 1548-5943. doi:10.1146/annurev-clinpsy-050718-095530. Consultado em 10 de fevereiro de 2021