Macielag MJ (2012). „Chemical properties of antibacterials and their uniqueness”. Ур.: Dougherty TJ, Pucci MJ. Antibiotic Discovery and Development. стр. 801—2. ISBN978-1-4614-1400-1. „The majority of [oral] drugs from the general reference set have molecular weights below 550. In contrast the molecular weight distribution of oral antibacterial agents is bimodal—between 340 and 450 Da but with another group in the 700–900 molecular weight range.”
doi.org
Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD (jun 2002). „Molecular properties that influence the oral bioavailability of drug candidates”. J. Med. Chem. 45 (12): 2615—23. PMID12036371. doi:10.1021/jm020017n.
Lipinski CA (decembar 2004). „Lead-and drug-like compounds: the rule-of-five revolution”. Drug Discovery Today: Technologies. 1 (4): 337—341. doi:10.1016/j.ddtec.2004.11.007.
Leeson PD, Springthorpe B (novembar 2007). „The influence of drug-like concepts on decision-making in medicinal chemistry”. Nature Reviews Drug Discovery. 6 (11): 881—90. PMID17971784. doi:10.1038/nrd2445.
Arkin MR, Wells JA (april 2004). „Small-molecule inhibitors of protein-protein interactions: progressing towards the dream”. Nature Reviews Drug Discovery. 3 (4): 301—17. PMID15060526. doi:10.1038/nrd1343.
nih.gov
ncbi.nlm.nih.gov
Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD (jun 2002). „Molecular properties that influence the oral bioavailability of drug candidates”. J. Med. Chem. 45 (12): 2615—23. PMID12036371. doi:10.1021/jm020017n.
Leeson PD, Springthorpe B (novembar 2007). „The influence of drug-like concepts on decision-making in medicinal chemistry”. Nature Reviews Drug Discovery. 6 (11): 881—90. PMID17971784. doi:10.1038/nrd2445.
Arkin MR, Wells JA (april 2004). „Small-molecule inhibitors of protein-protein interactions: progressing towards the dream”. Nature Reviews Drug Discovery. 3 (4): 301—17. PMID15060526. doi:10.1038/nrd1343.
