Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. August 1991, 66 (4): 807–15. PMID 1715244. doi:10.1016/0092-8674(91)90124-H.
Yang J, Symes K, Mercola M, Schreiber SL. Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. Current Biology. January 1998, 8 (1): 11–8. PMID 9427627. doi:10.1016/S0960-9822(98)70015-6.
Stockwell BR, Schreiber SL. Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers. Current Biology. June 1998, 8 (13): 761–70. PMID 9651680. doi:10.1016/S0960-9822(98)70299-4.
Brown EJ, Albers MW, Shin TB; et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. June 1994, 369 (6483): 756–8. PMID 8008069. doi:10.1038/369756a0. 引文格式1维护:显式使用等标签 (link)
Shamji AF, Nghiem P, Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Molecular Cell. August 2003, 12 (2): 271–80. PMID 14536067. doi:10.1016/j.molcel.2003.08.016.
Taunton J, Hassig CA, Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. April 1996, 272 (5260): 408–11. PMID 8602529. doi:10.1126/science.272.5260.408.
(a) Schreiber SL. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. March 2000, 287 (5460): 1964–9. PMID 10720315. doi:10.1126/science.287.5460.1964. (b) Burke MD, Berger EM, Schreiber SL. Generating diverse skeletons of small molecules combinatorially. Science. October 2003, 302 (5645): 613–8. PMID 14576427. doi:10.1126/science.1089946. (c) Burke MD, Schreiber SL. A planning strategy for diversity-oriented synthesis. Angewandte Chemie. January 2004, 43 (1): 46–58. PMID 14694470. doi:10.1002/anie.200300626.
Strausberg RL, Schreiber SL. From knowing to controlling: a path from genomics to drugs using small molecule probes. Science. April 2003, 300 (5617): 294–5. PMID 12690189. doi:10.1126/science.1083395.
Stockwell BR, Haggarty SJ, Schreiber SL. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chemistry & Biology. February 1999, 6 (2): 71–83. PMID 10021420. doi:10.1016/S1074-5521(99)80004-0.
Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. October 1999, 286 (5441): 971–4. PMID 10542155. doi:10.1126/science.286.5441.971.
Schreiber SL. Small molecules: the missing link in the central dogma. Nature Chemical Biology. July 2005, 1 (2): 64–6. PMID 16407997. doi:10.1038/nchembio0705-64.
nih.gov
ncbi.nlm.nih.gov
Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. August 1991, 66 (4): 807–15. PMID 1715244. doi:10.1016/0092-8674(91)90124-H.
Schreiber SL, Crabtree GR. Immunophilins, ligands, and the control of signal transduction. Harvey Lectures. 1995, 91: 99–114. PMID 9127988.
Yang J, Symes K, Mercola M, Schreiber SL. Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. Current Biology. January 1998, 8 (1): 11–8. PMID 9427627. doi:10.1016/S0960-9822(98)70015-6.
Stockwell BR, Schreiber SL. Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers. Current Biology. June 1998, 8 (13): 761–70. PMID 9651680. doi:10.1016/S0960-9822(98)70299-4.
Brown EJ, Albers MW, Shin TB; et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. June 1994, 369 (6483): 756–8. PMID 8008069. doi:10.1038/369756a0. 引文格式1维护:显式使用等标签 (link)
Shamji AF, Nghiem P, Schreiber SL. Integration of growth factor and nutrient signaling: implications for cancer biology. Molecular Cell. August 2003, 12 (2): 271–80. PMID 14536067. doi:10.1016/j.molcel.2003.08.016.
Taunton J, Hassig CA, Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. April 1996, 272 (5260): 408–11. PMID 8602529. doi:10.1126/science.272.5260.408.
(a) Schreiber SL. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. March 2000, 287 (5460): 1964–9. PMID 10720315. doi:10.1126/science.287.5460.1964. (b) Burke MD, Berger EM, Schreiber SL. Generating diverse skeletons of small molecules combinatorially. Science. October 2003, 302 (5645): 613–8. PMID 14576427. doi:10.1126/science.1089946. (c) Burke MD, Schreiber SL. A planning strategy for diversity-oriented synthesis. Angewandte Chemie. January 2004, 43 (1): 46–58. PMID 14694470. doi:10.1002/anie.200300626.
Strausberg RL, Schreiber SL. From knowing to controlling: a path from genomics to drugs using small molecule probes. Science. April 2003, 300 (5617): 294–5. PMID 12690189. doi:10.1126/science.1083395.
Stockwell BR, Haggarty SJ, Schreiber SL. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chemistry & Biology. February 1999, 6 (2): 71–83. PMID 10021420. doi:10.1016/S1074-5521(99)80004-0.
Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. October 1999, 286 (5441): 971–4. PMID 10542155. doi:10.1126/science.286.5441.971.
Schreiber SL. Small molecules: the missing link in the central dogma. Nature Chemical Biology. July 2005, 1 (2): 64–6. PMID 16407997. doi:10.1038/nchembio0705-64.