The Autophagy, Inflammation and Metabolism Center or AIM Center is an NIH-funded Center of Biomedical Research Excellence focused on the study of autophagy as a fundamental biological process and how it intersects with metabolism and quality control processes in eukaryotic cells. A special emphasis is on the role or autophagy in a wide spectrum of diseases with metabolic, inflammatory and immunological aspects. At the fundamental level, autophagy is a cytoplasmic pathway for the disposal of damaged or surplus organelles such as mitochondria, peroxisomes, lysosomes, endoplasmic reticulum, ribosomes, protein aggregates and also serves as a catabolic process providing nutrients through autodigestion at times of starvation. Autophagy has been implicated in cancer, neurodegeneration such as Alzheimer's disease, Huntington's disease and Parkinson's disease, diabetes, development, infections and immune diseases, as well as a process of relevance for aging. More information...
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