Greenwood is a city in and the county seat of Greenwood County, South Carolina, United States. The population in the 2020 United States Census was 22,545 down from 23,222 at the 2010 census. The city is home to Lander University. Greenwood is located slightly northwest of the center of Greenwood County. According to the United States Census Bureau, the city has a total area of 16.3 square miles (42.3 km2), of which 16.2 square miles (42.0 km2) are land and 0.1 square miles (0.3 km2), or 0.72%, are water. U.S. Routes 25, 178 and 221 pass through the eastern side of the city, bypassing the downtown area. US 25 leads north 51 miles (82 km) to Greenville and south 63 miles (101 km) to Augusta, Georgia, US 178 leads northwest 42 miles (68 km) to Anderson and southeast 29 miles (47 km) to Saluda, and US 221 leads northeast 26 miles (42 km) to Laurens and southwest 23 miles (37 km) to McCormick. More information...
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