Brookmeyer R, Gray S, Kawas C «Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset». Am J Public Health, 88, 9, setembre 1998, pàg. 1337–42. DOI: 10.2105/AJPH.88.9.1337. PMC: 1509089. PMID: 9736873.
Waldemar G, Dubois B, Emre M, et al. «Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline». Eur J Neurol, 14, 1, gener 2007, pàg. e1–26. DOI: 10.1111/j.1468-1331.2006.01605.x. PMID: 17222085.
Tabert MH, Liu X, Doty RL, Serby M, Zamora D, Pelton GH, Marder K, Albers MW, Stern Y, Devanand DP «A 10-item smell identification scale related to risk for Alzheimer's disease». Ann. Neurol., 58, 1, 2005, pàg. 155–160. DOI: 10.1002/ana.20533. PMID: 15984022.
Mölsä PK, Marttila RJ, Rinne UK «Survival and cause of death in Alzheimer's disease and multi-infarct dementia». Acta Neurol Scand, 74, 2, agost 1986, pàg. 103–7. DOI: 10.1111/j.1600-0404.1986.tb04634.x. PMID: 3776457 [Consulta: 4 agost 2008].
Thompson CA, Spilsbury K, Hall J, Birks Y, Barnes C, Adamson J «Systematic review of information and support interventions for caregivers of people with dementia». BMC Geriatr, 7, 2007, pàg. 18. DOI: 10.1186/1471-2318-7-18. PMC: 1951962. PMID: 17662119.
Schneider J, Murray J, Banerjee S, Mann A «EUROCARE: a cross-national study of co-resident spouse carers for people with Alzheimer's disease: I—Factors associated with carer burden». International Journal of Geriatric Psychiatry, 14, 8, agost 1999, pàg. 651–661. DOI: 10.1002/(SICI)1099-1166(199908)14:8<651::AID-GPS992>3.0.CO;2-B. PMID: 10489656 [Consulta: 4 juliol 2008].
Murray J, Schneider J, Banerjee S, Mann A «EUROCARE: a cross-national study of co-resident spouse carers for people with Alzheimer's disease: II--A qualitative analysis of the experience of caregiving». International Journal of Geriatric Psychiatry, 14, 8, agost 1999, pàg. 662–667. DOI: 10.1002/(SICI)1099-1166(199908)14:8<662::AID-GPS993>3.0.CO;2-4. PMID: 10489657.
Bäckman L, Jones S, Berger AK, Laukka EJ, Small BJ «Multiple cognitive deficits during the transition to Alzheimer's disease». J Intern Med, 256, 3, Sep 2004, pàg. 195–204. DOI: 10.1111/j.1365-2796.2004.01386.x. PMID: 15324363.
Nygård L «Instrumental activities of daily living: a stepping-stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment?». Acta Neurol Scand, Suppl, 179, 2003, pàg. 42–6. DOI: 10.1034/j.1600-0404.107.s179.8.x. PMID: 12603250.
Arnáiz E, Almkvist O «Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease». Acta Neurol. Scand., Suppl., 179, 2003, pàg. 34–41. DOI: 10.1034/j.1600-0404.107.s179.7.x. PMID: 12603249 [Consulta: 12 juny 2008].
Petersen RC «The current status of mild cognitive impairment—what do we tell our patients?». Nat Clin Pract Neurol, 3, 2, febrer 2007, pàg. 60–1. DOI: 10.1038/ncpneuro0402. PMID: 17279076.
Förstl H, Kurz A «Clinical features of Alzheimer's disease». European Archives of Psychiatry and Clinical Neuroscience, 249, 6, 1999, pàg. 288–290. DOI: 10.1007/s004060050101. PMID: 10653284.
Carlesimo GA, Oscar-Berman M «Memory deficits in Alzheimer's patients: a comprehensive review». Neuropsychol Rev, 3, 2, juny 1992, pàg. 119–69. DOI: 10.1007/BF01108841. PMID: 1300219.
Jelicic M, Bonebakker AE, Bonke B «Implicit memory performance of patients with Alzheimer's disease: a brief review». International Psychogeriatrics, 7, 3, 1995, pàg. 385–392. DOI: 10.1017/S1041610295002134. PMID: 8821346.
Taler V, Phillips NA «Language performance in Alzheimer's disease and mild cognitive impairment: a comparative review». J Clin Exp Neuropsychol, 30, 5, Jul 2008, pàg. 501–56. DOI: 10.1080/13803390701550128. PMID: 1856925.
Shen ZX «Brain cholinesterases: II. The molecular and cellular basis of Alzheimer's disease». Med Hypotheses, 63, 2, 2004, pàg. 308–21. DOI: 10.1016/j.mehy.2004.02.031. PMID: 15236795.
Hardy J, Allsop D «Amyloid deposition as the central event in the aetiology of Alzheimer's disease». Trends Pharmacol. Sci., 12, 10, octubre 1991, pàg. 383–88. DOI: 10.1016/0165-6147(91)90609-V. PMID: 1763432.
Mudher A, Lovestone S «Alzheimer's disease-do tauists and baptists finally shake hands?». Trends Neurosci., 25, 1, gener 2002, pàg. 22–26. DOI: 10.1016/S0166-2236(00)02031-2. PMID: 11801334.
Nistor M, Don M, Parekh M, et al. «Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain». Neurobiol Aging, 28, 10, octubre 2007, pàg. 1493–1506. DOI: 10.1016/j.neurobiolaging.2006.06.023. PMID: 16904243.
Polvikoski T, Sulkava R, Haltia M, et al. «Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein». N Engl J Med, 333, 19, novembre 1995, pàg. 1242–47. DOI: 10.1056/NEJM199511093331902. PMID: 7566000.
Transgenic mice:
Games D, Adams D, Alessandrini R, et al. «Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein». Nature, 373, 6514, febrer 1995, pàg. 523–27. DOI: 10.1038/373523a0. PMID: 7845465.
Holmes C, Boche D, Wilkinson D, et al. «Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial». Lancet, 372, 9634, 2008, pàg. 216–23. DOI: 10.1016/S0140-6736(08)61075-2. PMID: 18640458.
Lacor PN,et al. «Aß Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease». Journal of Neuroscience, 27, 4, gener 2007, pàg. 796–807. DOI: 10.1523/JNEUROSCI.3501-06.2007. PMID: 17251419.
Lauren J, Gimbel D, et al. «Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers». Nature, 457, 7233, febrer 2009, pàg. 1128–32. DOI: 10.1038/nature07761. PMID: 19242475.
Nikolaev, Anatoly; Todd McLaughlin, Dennis O'Leary, Marc Tessier-Lavigne «N-APP binds DR6 to cause axon pruning and neuron death via distinct caspases». Nature, 457, 7232, 19-02-2009, pàg. 981–989. DOI: 10.1038/nature07767. ISSN: 0028-0836. PMC: 2677572. PMID: 19225519 [Consulta: maig 2009].
Iqbal K, Alonso Adel C, Chen S, et al. «Tau pathology in Alzheimer disease and other tauopathies». Biochim Biophys Acta, 1739, 2-3, 2005, pàg. 198–210. DOI: 10.1016/j.bbadis.2004.09.008. PMID: 15615638.
Chun W, Johnson GV «The role of tau phosphorylation and cleavage in neuronal cell death». Front Biosci, 12, 2007, pàg. 733–56. DOI: 10.2741/2097. PMID: 17127334.
Bouras C, Hof PR, Giannakopoulos P, Michel JP, Morrison JH «Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital». Cereb. Cortex, 4, 2, 1994, pàg. 138–50. DOI: 10.1093/cercor/4.2.138. PMID: 8038565.
Kotzbauer PT, Trojanowsk JQ, Lee VM «Lewy body pathology in Alzheimer's disease». J Mol Neurosci, 17, 2, Oct 2001, pàg. 225–32. DOI: 10.1385/JMN:17:2:225. PMID: 11816795.
Hashimoto M, Rockenstein E, Crews L, Masliah E «Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases». Neuromolecular Med., 4, 1–2, 2003, pàg. 21–36. DOI: 10.1385/NMM:4:1-2:21. PMID: 14528050.
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J «Synapse formation and function is modulated by the amyloid precursor protein». J. Neurosci., 26, 27, juliol 2006, pàg. 7212–21. DOI: 10.1523/JNEUROSCI.1450-06.2006. PMID: 16822978.
Turner PR, O'Connor K, Tate WP, Abraham WC «Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory». Prog. Neurobiol., 70, 1, maig 2003, pàg. 1–32. DOI: 10.1016/S0301-0082(03)00089-3. PMID: 12927332.
Hooper NM «Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein». Biochem. Soc. Trans., 33, Pt 2, abril 2005, pàg. 335–8. DOI: 10.1042/BST0330335. PMID: 15787600.
Ohnishi S, Takano K «Amyloid fibrils from the viewpoint of protein folding». Cell. Mol. Life Sci., 61, 5, març 2004, pàg. 511–24. DOI: 10.1007/s00018-003-3264-8. PMID: 15004691.
Van Broeck B, Van Broeckhoven C, Kumar-Singh S «Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches». Neurodegener Dis, 4, 5, 2007, pàg. 349–65. DOI: 10.1159/000105156. PMID: 17622778.
Yankner BA, Duffy LK, Kirschner DA «Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides». Science (journal), 250, 4978, octubre 1990, pàg. 279–82. DOI: 10.1126/science.2218531. PMID: 2218531.
Chen X, Yan SD «Mitochondrial Abeta: a potential cause of metabolic dysfunction in Alzheimer's disease». IUBMB Life, 58, 12, desembre 2006, pàg. 686–94. DOI: 10.1080/15216540601047767. PMID: 17424907.
Greig NH, Mattson MP, Perry T, et al. «New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists». Ann. N. Y. Acad. Sci., 1035, desembre 2004, pàg. 290–315. DOI: 10.1196/annals.1332.018. PMID: 15681814.
Shioi J, Georgakopoulos A, Mehta P, et al. «FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta.». J Neurochem., 101, 3, 2007, pàg. 674–81. DOI: 10.1111/j.1471-4159.2006.04391.x. PMID: 17254019.
Strittmatter WJ, Saunders AM, Schmechel D, et al. «Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease». Proc. Natl. Acad. Sci. USA, 90, 5, març 1993, pàg. 1977–81. DOI: 10.1073/pnas.90.5.1977. PMC: 46003. PMID: 8446617.
Mahley RW, Weisgraber KH, Huang Y «Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease». Proc. Natl. Acad. Sci. U.S.A., 103, 15, abril 2006, pàg. 5644–51. DOI: 10.1073/pnas.0600549103. PMC: 1414631. PMID: 16567625.
Mendez MF «The accurate diagnosis of early-onset dementia». International Journal of Psychiatry Medicine, 36, 4, 2006, pàg. 401–412. DOI: 10.2190/Q6J4-R143-P630-KW41. PMID: 17407994.
Klafki HW, Staufenbiel M, Kornhuber J, Wiltfang J «Therapeutic approaches to Alzheimer's disease». Brain, 129, Pt 11, novembre 2006, pàg. 2840–55. DOI: 10.1093/brain/awl280. PMID: 17018549.
Dubois B, Feldman HH, Jacova C, et al. «Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria». Lancet Neurol, 6, 8, 2007, pàg. 734–46. DOI: 10.1016/S1474-4422(07)70178-3. PMID: 17616482.
Pasquier F «Early diagnosis of dementia: neuropsychology». J. Neurol., 246, 1, gener 1999, pàg. 6–15. DOI: 10.1007/s004150050299. PMID: 9987708.
Harvey PD, Moriarty PJ, Kleinman L, et al. «The validation of a caregiver assessment of dementia: the Dementia Severity Scale». Alzheimer Dis Assoc Disord, 19, 4, 2005, pàg. 186–94. DOI: 10.1097/01.wad.0000189034.43203.60. PMID: 16327345.
Antoine C, Antoine P, Guermonprez P, Frigard B «[Awareness of deficits and anosognosia in Alzheimer's disease.]» (en francès). Encephale, 30, 6, 2004, pàg. 570–7. DOI: 10.1016/S0013-7006(04)95472-3. PMID: 15738860.
Clarfield AM «The decreasing prevalence of reversible dementias: an updated meta-analysis». Arch. Intern. Med., 163, 18, octubre 2003, pàg. 2219–29. DOI: 10.1001/archinte.163.18.2219. PMID: 14557220.
Potter GG, Steffens DC «Contribution of depression to cognitive impairment and dementia in older adults». Neurologist, 13, 3, maig 2007, pàg. 105–17. DOI: 10.1097/01.nrl.0000252947.15389.a9. PMID: 17495754.
Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL «Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation». Clin Nucl Med, 31, 7, juliol 2006, pàg. 376–8. DOI: 10.1097/01.rlu.0000222736.81365.63. PMID: 16785801.
Dougall NJ, Bruggink S, Ebmeier KP «Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia». Am J Geriatr Psychiatry, 12, 6, 2004, pàg. 554–70. DOI: 10.1176/appi.ajgp.12.6.554. PMID: 15545324.
Marksteiner J, Hinterhuber H, Humpel C «Cerebrospinal fluid biomarkers for diagnosis of Alzheimer's disease: beta-amyloid(1-42), tau, phospho-tau-181 and total protein». Drugs Today, 43, 6, juny 2007, pàg. 423–31. DOI: 10.1358/dot.2007.43.6.1067341. PMID: 17612711.
PiB PET:
Kemppainen NM, Aalto S, Karrasch M, et al. «Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease». Ann. Neurol., 63, 1, gener 2008, pàg. 112–8. DOI: 10.1002/ana.21212. PMID: 18023012.
Szekely CA, Breitner JC, Zandi PP «Prevention of Alzheimer's disease». Int Rev Psychiatry, 19, 6, 2007, pàg. 693–706. DOI: 10.1080/09540260701797944. PMID: 18092245.
Patterson C, Feightner JW, Garcia A, Hsiung GY, MacKnight C, Sadovnick AD «Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease». CMAJ, 178, 5, febrer 2008, pàg. 548–56. DOI: 10.1503/cmaj.070796. PMC: 2244657. PMID: 18299540.
Rosendorff C, Beeri MS, Silverman JM «Cardiovascular risk factors for Alzheimer's disease». Am J Geriatr Cardiol, 16, 3, 2007, pàg. 143–9. DOI: 10.1111/j.1076-7460.2007.06696.x. PMID: 17483665.
Reiss AB, Wirkowski E «Role of HMG-CoA reductase inhibitors in neurological disorders : progress to date». Drugs, 67, 15, 2007, pàg. 2111–20. DOI: 10.2165/00003495-200767150-00001. PMID: 17927279.
Solfrizzi V, Capurso C, D'Introno A, et al. «Lifestyle-related factors in predementia and dementia syndromes». Expert Rev Neurother, 8, 1, gener 2008, pàg. 133–58. DOI: 10.1586/14737175.8.1.133. PMID: 18088206.
Panza F, Capurso C, D'Introno A, Colacicco AM, Frisardi V, Lorusso M, Santamato A, Seripa D, Pilotto A, Scafato E, Vendemiale G, Capurso A, Solfrizzi V. «Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes». J Alzheimers Dis, 17, 1, 5-2009, pàg. 7–31. DOI: 10.3233/JAD-2009-1009. PMID: 19494429.
Boothby LA, Doering PL «Vitamin C and vitamin E for Alzheimer's disease». Ann Pharmacother, 39, 12, desembre 2005, pàg. 2073–80. DOI: 10.1345/aph.1E495. PMID: 16227450.
Isaac MG, Quinn R, Tabet N «Vitamin E for Alzheimer's disease and mild cognitive impairment». Cochrane Database Syst Rev, 3, 2008, pàg. CD002854. DOI: 10.1002/14651858.CD002854.pub2. PMID: 18646084.
Malouf R, Grimley Evans J «Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people». Cochrane Database Syst Rev, 4, 2008, pàg. CD004514. DOI: 10.1002/14651858.CD004514.pub2. PMID: 18843658.
Szekely CA, Town T, Zandi PP «NSAIDs for the chemoprevention of Alzheimer's disease». Subcell Biochem, 42, 2007, pàg. 229–48. DOI: 10.1007/1-4020-5688-5_11. PMID: 17612054.
Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL «A potential role of the curry spice curcumin in Alzheimer's disease». Curr Alzheimer Res, 2, 2, abril 2005, pàg. 131–6. DOI: 10.2174/1567205053585882. ISSN: 1567-2050. PMC: 1702408. PMID: 15974909.
Aggarwal BB, Harikumar KB «Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases». Int J Biochem Cell Biol, 41, 1, gener 2009, pàg. 40–59. DOI: 10.1016/j.biocel.2008.06.010. PMID: 18662800.
Farquhar C, Marjoribanks J, Lethaby A, Suckling JA, Lamberts Q «Long term hormone therapy for perimenopausal and postmenopausal women». Cochrane Database Syst Rev, 2, 15-04-2009, pàg. CD004143. DOI: 10.1002/14651858.CD004143.pub3. PMID: 19370593.
Barrett-Connor, E; Laughlin, GA «Endogenous and exogenous estrogen, cognitive function, and dementia in postmenopausal women: evidence from epidemiologic studies and clinical trials». Semin Reprod Med, 27, 3, 5-2009, pàg. 275–82. DOI: 10.1055/s-0029-1216280. PMC: 2701737. PMID: 19401958.
Paradise M, Cooper C, Livingston G «Systematic review of the effect of education on survival in Alzheimer's disease». Int Psychogeriatr, 21, 1, febrer 2009, pàg. 25–32. DOI: 10.1017/S1041610208008053. PMID: 19026089.
Rondeau V, Commenges D, Jacqmin-Gadda H, Dartigues JF «Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study». Am J Epidemiol, 152, 1, juliol 2000, pàg. 59–66. DOI: 10.1093/aje/152.1.59. PMC: 2215380. PMID: 10901330.
Santibáñez M, Bolumar F, García AM «Occupational risk factors in Alzheimer's disease: a review assessing the quality of published epidemiological studies». Occupational and Environmental Medicine, 64, 11, 2007, pàg. 723–732. DOI: 10.1136/oem.2006.028209. PMID: 17525096.
Seidler A, Geller P, Nienhaus A, et al. «Occupational exposure to low frequency magnetic fields and dementia: a case-control study». Occup Environ Med, 64, 2, febrer 2007, pàg. 108–14. DOI: 10.1136/oem.2005.024190. PMID: 17043077.
Martyn CN, Coggon DN, Inskip H, Lacey RF, Young WF «Aluminum concentrations in drinking water and risk of Alzheimer's disease». Epidemiology, 8, 3, maig 1997, pàg. 281–6. DOI: 10.1097/00001648-199705000-00009. PMID: 9115023.
Graves AB, Rosner D, Echeverria D, Mortimer JA, Larson EB «Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease». Occup Environ Med, 55, 9, setembre 1998, pàg. 627–33. DOI: 10.1136/oem.55.9.627. PMC: 1757634. PMID: 9861186.
Hug, K; Röösli, M & Rapp, R «Magnetic field exposure and neurodegenerative diseases--recent epidemiological studies». Sozial- und Praventivmedizin, 51, 4, 2006, pàg. 210–20. DOI: 10.1007/s00038-006-5096-4. PMID: 17193783.
Hardell, L; Sage, C «Biological effects from electromagnetic field exposure and public exposure standards». Biomedicine & pharmacotherapy, 62, 2, Feb 2008, pàg. 104–9. DOI: 10.1016/j.biopha.2007.12.004. PMID: 18242044.
Davanipour, Z; Sobel, E «Long-term exposure to magnetic fields and the risks of Alzheimer's disease and breast cancer: Further biological research». Pathophysiology, ISP 16, 2-3, Aug 2009, pàg. 149–56. DOI: 10.1016/j.pathophys.2009.01.005. PMID: 19278839.
Kheifets, L; Bowman, Jd et al. «Future needs of occupational epidemiology of extremely low frequency electric and magnetic fields: review and recommendations». Occupational and environmental medicine, 66, 2, Feb 2009, pàg. 72–80. DOI: 10.1136/oem.2007.037994. PMID: 18805878.
Ballard C, Waite J «The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease». Cochrane Database Syst Rev, 1, 2006, pàg. CD003476. DOI: 10.1002/14651858.CD003476.pub2. PMID: 16437455.
Ballard C, Hanney ML, Theodoulou M, Douglas S, McShane R, Kossakowski K, Gill R, Juszczak E, Yu L-M, Jacoby R «The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial». Lancet Neurology, 8, 2, 09-01-2009, pàg. 151. DOI: 10.1016/S1474-4422(08)70295-3. PMID: 19138567.
Bottino CM, Carvalho IA, Alvarez AM, et al. «Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study». Clin Rehabil, 19, 8, 2005, pàg. 861–869. DOI: 10.1191/0269215505cr911oa. PMID: 16323385.
Hermans DG, Htay UH, McShane R «Non-pharmacological interventions for wandering of people with dementia in the domestic setting». Cochrane Database Syst Rev, 1, 2007, pàg. CD005994. DOI: 10.1002/14651858.CD005994.pub2. PMID: 17253573.
Robinson L, Hutchings D, Dickinson HO, et al. «Effectiveness and acceptability of non-pharmacological interventions to reduce wandering in dementia: a systematic review». Int J Geriatr Psychiatry, 22, 1, 2007, pàg. 9–22. DOI: 10.1002/gps.1643. PMID: 17096455.
Chung JC, Lai CK, Chung PM, French HP «Snoezelen for dementia». Cochrane Database Syst Rev, 4, 2002, pàg. CD003152. DOI: 10.1002/14651858.CD003152. PMID: 12519587.
Woods B, Spector A, Jones C, Orrell M, Davies S «Reminiscence therapy for dementia». Cochrane Database Syst Rev, 2, 2005, pàg. CD001120. DOI: 10.1002/14651858.CD001120.pub2. PMID: 15846613.
Zetteler J «Effectiveness of simulated presence therapy for individuals with dementia: a systematic review and meta-analysis». Aging Ment Health, 12, 6, novembre 2008, pàg. 779–85. DOI: 10.1080/13607860802380631. PMID: 19023729.
Spector A, Orrell M, Davies S, Woods B «Withdrawn: Reality orientation for dementia». Cochrane Database Syst Rev, 3, 2000, pàg. CD001119. DOI: 10.1002/14651858.CD001119.pub2. PMID: 17636652.
Spector A, Thorgrimsen L, Woods B, et al. «Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial». Br J Psychiatry, 183, 2003, pàg. 248–254. DOI: 10.1192/bjp.183.3.248. PMID: 12948999.
Dunne TE, Neargarder SA, Cipolloni PB, Cronin-Golomb A «Visual contrast enhances food and liquid intake in advanced Alzheimer's disease». Clinical Nutrition, 23, 4, 2004, pàg. 533–538. DOI: 10.1016/j.clnu.2003.09.015. PMID: 15297089.
Gambassi G, Landi F, Lapane KL, Sgadari A, Mor V, Bernabei R «Predictors of mortality in patients with Alzheimer's disease living in nursing homes». J. Neurol. Neurosurg. Psychiatr., 67, 1, juliol 1999, pàg. 59–65. DOI: 10.1136/jnnp.67.1.59. PMC: 1736445. PMID: 10369823.
Shega JW, Levin A, Hougham GW, et al. «Palliative Excellence in Alzheimer Care Efforts (PEACE): a program description». J Palliat Med, 6, 2, abril 2003, pàg. 315–20. DOI: 10.1089/109662103764978641. PMID: 12854952.
Dodge HH, Shen C, Pandav R, DeKosky ST, Ganguli M «Functional transitions and active life expectancy associated with Alzheimer disease». Arch. Neurol., 60, 2, febrer 2003, pàg. 253–9. DOI: 10.1001/archneur.60.2.253. PMID: 12580712.
Jagger C, Clarke M, Stone A «Predictors of survival with Alzheimer's disease: a community-based study». Psychol Med, 25, 1, gener 1995, pàg. 171–7. DOI: 10.1017/S0033291700028191. PMID: 7792352.
Ganguli M, Dodge HH, Shen C, Pandav RS, DeKosky ST «Alzheimer disease and mortality: a 15-year epidemiological study». Arch. Neurol., 62, 5, maig 2005, pàg. 779–84. DOI: 10.1001/archneur.62.5.779. PMID: 15883266.
Bermejo-Pareja F, Benito-León J, Vega S, Medrano MJ, Román GC «Incidence and subtypes of dementia in three elderly populations of central Spain». J. Neurol. Sci., 264, 1–2, gener 2008, pàg. 63–72. DOI: 10.1016/j.jns.2007.07.021. PMID: 17727890.
Di Carlo A, Baldereschi M, Amaducci L, et al. «Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study». J Am Geriatr Soc, 50, 1, 2002, pàg. 41–8. DOI: 10.1046/j.1532-5415.2002.50006.x. PMID: 12028245.
2000 U.S. estimates:
Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA «Alzheimer disease in the US population: prevalence estimates using the 2000 census». Arch. Neurol., 60, 8, 2003, pàg. 1119–22. DOI: 10.1001/archneur.60.8.1119. PMID: 12925369.
Brookmeyer R, Gray S, Kawas C «Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset». Am J Public Health, 88, 9, setembre 1998, pàg. 1337–42. DOI: 10.2105/AJPH.88.9.1337. PMC: 1509089. PMID: 9736873.
Waldemar G, Dubois B, Emre M, et al. «Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline». Eur J Neurol, 14, 1, gener 2007, pàg. e1–26. DOI: 10.1111/j.1468-1331.2006.01605.x. PMID: 17222085.
Tabert MH, Liu X, Doty RL, Serby M, Zamora D, Pelton GH, Marder K, Albers MW, Stern Y, Devanand DP «A 10-item smell identification scale related to risk for Alzheimer's disease». Ann. Neurol., 58, 1, 2005, pàg. 155–160. DOI: 10.1002/ana.20533. PMID: 15984022.
Mölsä PK, Marttila RJ, Rinne UK «Survival and cause of death in Alzheimer's disease and multi-infarct dementia». Acta Neurol Scand, 74, 2, agost 1986, pàg. 103–7. DOI: 10.1111/j.1600-0404.1986.tb04634.x. PMID: 3776457 [Consulta: 4 agost 2008].
Mölsä PK, Marttila RJ, Rinne UK «Long-term survival and predictors of mortality in Alzheimer's disease and multi-infarct dementia». ActaNeurol Scand, 91, 3, març 1995, pàg. 159–64. PMID: 7793228.
Tiraboschi P, Hansen LA, Thal LJ, Corey-Bloom J «The importance of neuritic plaques and tangles to the development and evolution of AD». Neurology, 62, 11, juny 2004, pàg. 1984–9. PMID: 15184601.
Thompson CA, Spilsbury K, Hall J, Birks Y, Barnes C, Adamson J «Systematic review of information and support interventions for caregivers of people with dementia». BMC Geriatr, 7, 2007, pàg. 18. DOI: 10.1186/1471-2318-7-18. PMC: 1951962. PMID: 17662119.
Schneider J, Murray J, Banerjee S, Mann A «EUROCARE: a cross-national study of co-resident spouse carers for people with Alzheimer's disease: I—Factors associated with carer burden». International Journal of Geriatric Psychiatry, 14, 8, agost 1999, pàg. 651–661. DOI: 10.1002/(SICI)1099-1166(199908)14:8<651::AID-GPS992>3.0.CO;2-B. PMID: 10489656 [Consulta: 4 juliol 2008].
Murray J, Schneider J, Banerjee S, Mann A «EUROCARE: a cross-national study of co-resident spouse carers for people with Alzheimer's disease: II--A qualitative analysis of the experience of caregiving». International Journal of Geriatric Psychiatry, 14, 8, agost 1999, pàg. 662–667. DOI: 10.1002/(SICI)1099-1166(199908)14:8<662::AID-GPS993>3.0.CO;2-4. PMID: 10489657.
Bonin-Guillaume S, Zekry D, Giacobini E, Gold G, Michel JP «Impact économique de la démence (English: The economical impact of dementia)» (en francès). Presse Med, 34, 1, gener 2005, pàg. 35–41. ISSN: 0755-4982. PMID: 15685097.
Bäckman L, Jones S, Berger AK, Laukka EJ, Small BJ «Multiple cognitive deficits during the transition to Alzheimer's disease». J Intern Med, 256, 3, Sep 2004, pàg. 195–204. DOI: 10.1111/j.1365-2796.2004.01386.x. PMID: 15324363.
Nygård L «Instrumental activities of daily living: a stepping-stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment?». Acta Neurol Scand, Suppl, 179, 2003, pàg. 42–6. DOI: 10.1034/j.1600-0404.107.s179.8.x. PMID: 12603250.
Arnáiz E, Almkvist O «Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease». Acta Neurol. Scand., Suppl., 179, 2003, pàg. 34–41. DOI: 10.1034/j.1600-0404.107.s179.7.x. PMID: 12603249 [Consulta: 12 juny 2008].
Petersen RC «The current status of mild cognitive impairment—what do we tell our patients?». Nat Clin Pract Neurol, 3, 2, febrer 2007, pàg. 60–1. DOI: 10.1038/ncpneuro0402. PMID: 17279076.
Förstl H, Kurz A «Clinical features of Alzheimer's disease». European Archives of Psychiatry and Clinical Neuroscience, 249, 6, 1999, pàg. 288–290. DOI: 10.1007/s004060050101. PMID: 10653284.
Carlesimo GA, Oscar-Berman M «Memory deficits in Alzheimer's patients: a comprehensive review». Neuropsychol Rev, 3, 2, juny 1992, pàg. 119–69. DOI: 10.1007/BF01108841. PMID: 1300219.
Jelicic M, Bonebakker AE, Bonke B «Implicit memory performance of patients with Alzheimer's disease: a brief review». International Psychogeriatrics, 7, 3, 1995, pàg. 385–392. DOI: 10.1017/S1041610295002134. PMID: 8821346.
Taler V, Phillips NA «Language performance in Alzheimer's disease and mild cognitive impairment: a comparative review». J Clin Exp Neuropsychol, 30, 5, Jul 2008, pàg. 501–56. DOI: 10.1080/13803390701550128. PMID: 1856925.
Frank EM «Effect of Alzheimer's disease on communication function». J S C Med Assoc, 90, 9, setembre 1994, pàg. 417–23. PMID: 7967534.
Gold DP, Reis MF, Markiewicz D, Andres D «When home caregiving ends: a longitudinal study of outcomes for caregivers of relatives with dementia». J Am Geriatr Soc, 43, 1, gener 1995, pàg. 10–6. PMID: 7806732.
Francis PT, Palmer AM, Snape M, Wilcock GK «The cholinergic hypothesis of Alzheimer's disease: a review of progress». J. Neurol. Neurosurg. Psychiatr., 66, 2, febrer 1999, pàg. 137–47. PMC: 1736202. PMID: 10071091.
Shen ZX «Brain cholinesterases: II. The molecular and cellular basis of Alzheimer's disease». Med Hypotheses, 63, 2, 2004, pàg. 308–21. DOI: 10.1016/j.mehy.2004.02.031. PMID: 15236795.
Hardy J, Allsop D «Amyloid deposition as the central event in the aetiology of Alzheimer's disease». Trends Pharmacol. Sci., 12, 10, octubre 1991, pàg. 383–88. DOI: 10.1016/0165-6147(91)90609-V. PMID: 1763432.
Mudher A, Lovestone S «Alzheimer's disease-do tauists and baptists finally shake hands?». Trends Neurosci., 25, 1, gener 2002, pàg. 22–26. DOI: 10.1016/S0166-2236(00)02031-2. PMID: 11801334.
Nistor M, Don M, Parekh M, et al. «Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain». Neurobiol Aging, 28, 10, octubre 2007, pàg. 1493–1506. DOI: 10.1016/j.neurobiolaging.2006.06.023. PMID: 16904243.
Polvikoski T, Sulkava R, Haltia M, et al. «Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein». N Engl J Med, 333, 19, novembre 1995, pàg. 1242–47. DOI: 10.1056/NEJM199511093331902. PMID: 7566000.
Transgenic mice:
Games D, Adams D, Alessandrini R, et al. «Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein». Nature, 373, 6514, febrer 1995, pàg. 523–27. DOI: 10.1038/373523a0. PMID: 7845465.
Holmes C, Boche D, Wilkinson D, et al. «Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial». Lancet, 372, 9634, 2008, pàg. 216–23. DOI: 10.1016/S0140-6736(08)61075-2. PMID: 18640458.
Lacor PN,et al. «Aß Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease». Journal of Neuroscience, 27, 4, gener 2007, pàg. 796–807. DOI: 10.1523/JNEUROSCI.3501-06.2007. PMID: 17251419.
Lauren J, Gimbel D, et al. «Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers». Nature, 457, 7233, febrer 2009, pàg. 1128–32. DOI: 10.1038/nature07761. PMID: 19242475.
Nikolaev, Anatoly; Todd McLaughlin, Dennis O'Leary, Marc Tessier-Lavigne «N-APP binds DR6 to cause axon pruning and neuron death via distinct caspases». Nature, 457, 7232, 19-02-2009, pàg. 981–989. DOI: 10.1038/nature07767. ISSN: 0028-0836. PMC: 2677572. PMID: 19225519 [Consulta: maig 2009].
Schmitz C, Rutten BP, Pielen A, et al. «Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease». Am J Pathol, 164, 4, 2004, pàg. 1495–1502. PMC: 1615337. PMID: 15039236.
Iqbal K, Alonso Adel C, Chen S, et al. «Tau pathology in Alzheimer disease and other tauopathies». Biochim Biophys Acta, 1739, 2-3, 2005, pàg. 198–210. DOI: 10.1016/j.bbadis.2004.09.008. PMID: 15615638.
Chun W, Johnson GV «The role of tau phosphorylation and cleavage in neuronal cell death». Front Biosci, 12, 2007, pàg. 733–56. DOI: 10.2741/2097. PMID: 17127334.
Alonso R, Pisa D, Rábano A, Carrasco L. «Alzheimer's disease and disseminated mycoses.». Eur J Clin Microbiol Infect Dis.. PMID: 24452965.
Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD. «Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease.». Sci Transl Med.. PMID: 27225182.
Pisa D, Alonso R, Rábano A, Rodal I, Carrasco L. «Different Brain Regions are Infected with Fungi in Alzheimer's Disease.». Nature Scientific Reports.. PMID: 26468932.
Ala TA, Doss RC, Sullivan CJ. «Reversible dementia: a case of cryptococcal meningitis masquerading as Alzheimer's disease.». J Alzheimers Dis.. PMID: 15505372.
Hoffmann M1, Muniz J, Carroll E, De Villasante J. «Cryptococcal meningitis misdiagnosed as Alzheimer's disease: complete neurological and cognitive recovery with treatment.». J Alzheimers Dis.. PMID: 19276545.
Bouras C, Hof PR, Giannakopoulos P, Michel JP, Morrison JH «Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital». Cereb. Cortex, 4, 2, 1994, pàg. 138–50. DOI: 10.1093/cercor/4.2.138. PMID: 8038565.
Kotzbauer PT, Trojanowsk JQ, Lee VM «Lewy body pathology in Alzheimer's disease». J Mol Neurosci, 17, 2, Oct 2001, pàg. 225–32. DOI: 10.1385/JMN:17:2:225. PMID: 11816795.
Hashimoto M, Rockenstein E, Crews L, Masliah E «Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases». Neuromolecular Med., 4, 1–2, 2003, pàg. 21–36. DOI: 10.1385/NMM:4:1-2:21. PMID: 14528050.
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J «Synapse formation and function is modulated by the amyloid precursor protein». J. Neurosci., 26, 27, juliol 2006, pàg. 7212–21. DOI: 10.1523/JNEUROSCI.1450-06.2006. PMID: 16822978.
Turner PR, O'Connor K, Tate WP, Abraham WC «Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory». Prog. Neurobiol., 70, 1, maig 2003, pàg. 1–32. DOI: 10.1016/S0301-0082(03)00089-3. PMID: 12927332.
Hooper NM «Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein». Biochem. Soc. Trans., 33, Pt 2, abril 2005, pàg. 335–8. DOI: 10.1042/BST0330335. PMID: 15787600.
Ohnishi S, Takano K «Amyloid fibrils from the viewpoint of protein folding». Cell. Mol. Life Sci., 61, 5, març 2004, pàg. 511–24. DOI: 10.1007/s00018-003-3264-8. PMID: 15004691.
Van Broeck B, Van Broeckhoven C, Kumar-Singh S «Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches». Neurodegener Dis, 4, 5, 2007, pàg. 349–65. DOI: 10.1159/000105156. PMID: 17622778.
Yankner BA, Duffy LK, Kirschner DA «Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides». Science (journal), 250, 4978, octubre 1990, pàg. 279–82. DOI: 10.1126/science.2218531. PMID: 2218531.
Chen X, Yan SD «Mitochondrial Abeta: a potential cause of metabolic dysfunction in Alzheimer's disease». IUBMB Life, 58, 12, desembre 2006, pàg. 686–94. DOI: 10.1080/15216540601047767. PMID: 17424907.
Greig NH, Mattson MP, Perry T, et al. «New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists». Ann. N. Y. Acad. Sci., 1035, desembre 2004, pàg. 290–315. DOI: 10.1196/annals.1332.018. PMID: 15681814.
Schindowski K, Belarbi K, Buée L «Neurotrophic factors in Alzheimer's disease: role of axonal transport». Genes, Brain and Behavior, 7, Suppl 1, Feb 2008, pàg. 43–56. PMID: 18184369.
Shioi J, Georgakopoulos A, Mehta P, et al. «FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta.». J Neurochem., 101, 3, 2007, pàg. 674–81. DOI: 10.1111/j.1471-4159.2006.04391.x. PMID: 17254019.
Strittmatter WJ, Saunders AM, Schmechel D, et al. «Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease». Proc. Natl. Acad. Sci. USA, 90, 5, març 1993, pàg. 1977–81. DOI: 10.1073/pnas.90.5.1977. PMC: 46003. PMID: 8446617.
Mahley RW, Weisgraber KH, Huang Y «Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease». Proc. Natl. Acad. Sci. U.S.A., 103, 15, abril 2006, pàg. 5644–51. DOI: 10.1073/pnas.0600549103. PMC: 1414631. PMID: 16567625.
Mendez MF «The accurate diagnosis of early-onset dementia». International Journal of Psychiatry Medicine, 36, 4, 2006, pàg. 401–412. DOI: 10.2190/Q6J4-R143-P630-KW41. PMID: 17407994.
Klafki HW, Staufenbiel M, Kornhuber J, Wiltfang J «Therapeutic approaches to Alzheimer's disease». Brain, 129, Pt 11, novembre 2006, pàg. 2840–55. DOI: 10.1093/brain/awl280. PMID: 17018549.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM «Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease». Neurology, 34, 7, juliol 1984, pàg. 939–44. PMID: 6610841.
Dubois B, Feldman HH, Jacova C, et al. «Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria». Lancet Neurol, 6, 8, 2007, pàg. 734–46. DOI: 10.1016/S1474-4422(07)70178-3. PMID: 17616482.
Blacker D, Albert MS, Bassett SS, Go RC, Harrell LE, Folstein MF «Reliability and validity of NINCDS-ADRDA criteria for Alzheimer's disease. The National Institute of Mental Health Genetics Initiative». Arch. Neurol., 51, 12, 1994, pàg. 1198–204. PMID: 7986174.
Ito N «[Clinical aspects of dementia]» (en japanese). Hokkaido Igaku Zasshi, 71, 3, maig 1996, pàg. 315–20. PMID: 8752526.
Tombaugh TN, McIntyre NJ «The mini-mental state examination: a comprehensive review». J Am Geriatr Soc, 40, 9, setembre 1992, pàg. 922–35. PMID: 1512391.
Pasquier F «Early diagnosis of dementia: neuropsychology». J. Neurol., 246, 1, gener 1999, pàg. 6–15. DOI: 10.1007/s004150050299. PMID: 9987708.
Harvey PD, Moriarty PJ, Kleinman L, et al. «The validation of a caregiver assessment of dementia: the Dementia Severity Scale». Alzheimer Dis Assoc Disord, 19, 4, 2005, pàg. 186–94. DOI: 10.1097/01.wad.0000189034.43203.60. PMID: 16327345.
Antoine C, Antoine P, Guermonprez P, Frigard B «[Awareness of deficits and anosognosia in Alzheimer's disease.]» (en francès). Encephale, 30, 6, 2004, pàg. 570–7. DOI: 10.1016/S0013-7006(04)95472-3. PMID: 15738860.
Cruz VT, Pais J, Teixeira A, Nunes B «[The initial symptoms of Alzheimer disease: caregiver perception]» (en portuguese). Acta Med Port, 17, 6, 2004, pàg. 435–44. PMID: 16197855.
Clarfield AM «The decreasing prevalence of reversible dementias: an updated meta-analysis». Arch. Intern. Med., 163, 18, octubre 2003, pàg. 2219–29. DOI: 10.1001/archinte.163.18.2219. PMID: 14557220.
Potter GG, Steffens DC «Contribution of depression to cognitive impairment and dementia in older adults». Neurologist, 13, 3, maig 2007, pàg. 105–17. DOI: 10.1097/01.nrl.0000252947.15389.a9. PMID: 17495754.
Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL «Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation». Clin Nucl Med, 31, 7, juliol 2006, pàg. 376–8. DOI: 10.1097/01.rlu.0000222736.81365.63. PMID: 16785801.
Dougall NJ, Bruggink S, Ebmeier KP «Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia». Am J Geriatr Psychiatry, 12, 6, 2004, pàg. 554–70. DOI: 10.1176/appi.ajgp.12.6.554. PMID: 15545324.
Marksteiner J, Hinterhuber H, Humpel C «Cerebrospinal fluid biomarkers for diagnosis of Alzheimer's disease: beta-amyloid(1-42), tau, phospho-tau-181 and total protein». Drugs Today, 43, 6, juny 2007, pàg. 423–31. DOI: 10.1358/dot.2007.43.6.1067341. PMID: 17612711.
PiB PET:
Kemppainen NM, Aalto S, Karrasch M, et al. «Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease». Ann. Neurol., 63, 1, gener 2008, pàg. 112–8. DOI: 10.1002/ana.21212. PMID: 18023012.
Prevention recommendations not supported:
Kawas CH «Medications and diet: protective factors for AD?». Alzheimer Dis Assoc Disord, 20, 3 Suppl 2, 2006, pàg. S89–96. PMID: 16917203.
Szekely CA, Breitner JC, Zandi PP «Prevention of Alzheimer's disease». Int Rev Psychiatry, 19, 6, 2007, pàg. 693–706. DOI: 10.1080/09540260701797944. PMID: 18092245.
Patterson C, Feightner JW, Garcia A, Hsiung GY, MacKnight C, Sadovnick AD «Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease». CMAJ, 178, 5, febrer 2008, pàg. 548–56. DOI: 10.1503/cmaj.070796. PMC: 2244657. PMID: 18299540.
Rosendorff C, Beeri MS, Silverman JM «Cardiovascular risk factors for Alzheimer's disease». Am J Geriatr Cardiol, 16, 3, 2007, pàg. 143–9. DOI: 10.1111/j.1076-7460.2007.06696.x. PMID: 17483665.
Reiss AB, Wirkowski E «Role of HMG-CoA reductase inhibitors in neurological disorders : progress to date». Drugs, 67, 15, 2007, pàg. 2111–20. DOI: 10.2165/00003495-200767150-00001. PMID: 17927279.
Solfrizzi V, Capurso C, D'Introno A, et al. «Lifestyle-related factors in predementia and dementia syndromes». Expert Rev Neurother, 8, 1, gener 2008, pàg. 133–58. DOI: 10.1586/14737175.8.1.133. PMID: 18088206.
Panza F, Capurso C, D'Introno A, Colacicco AM, Frisardi V, Lorusso M, Santamato A, Seripa D, Pilotto A, Scafato E, Vendemiale G, Capurso A, Solfrizzi V. «Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes». J Alzheimers Dis, 17, 1, 5-2009, pàg. 7–31. DOI: 10.3233/JAD-2009-1009. PMID: 19494429.
Boothby LA, Doering PL «Vitamin C and vitamin E for Alzheimer's disease». Ann Pharmacother, 39, 12, desembre 2005, pàg. 2073–80. DOI: 10.1345/aph.1E495. PMID: 16227450.
Isaac MG, Quinn R, Tabet N «Vitamin E for Alzheimer's disease and mild cognitive impairment». Cochrane Database Syst Rev, 3, 2008, pàg. CD002854. DOI: 10.1002/14651858.CD002854.pub2. PMID: 18646084.
Malouf R, Grimley Evans J «Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people». Cochrane Database Syst Rev, 4, 2008, pàg. CD004514. DOI: 10.1002/14651858.CD004514.pub2. PMID: 18843658.
Szekely CA, Town T, Zandi PP «NSAIDs for the chemoprevention of Alzheimer's disease». Subcell Biochem, 42, 2007, pàg. 229–48. DOI: 10.1007/1-4020-5688-5_11. PMID: 17612054.
Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL «A potential role of the curry spice curcumin in Alzheimer's disease». Curr Alzheimer Res, 2, 2, abril 2005, pàg. 131–6. DOI: 10.2174/1567205053585882. ISSN: 1567-2050. PMC: 1702408. PMID: 15974909.
Aggarwal BB, Harikumar KB «Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases». Int J Biochem Cell Biol, 41, 1, gener 2009, pàg. 40–59. DOI: 10.1016/j.biocel.2008.06.010. PMID: 18662800.
Farquhar C, Marjoribanks J, Lethaby A, Suckling JA, Lamberts Q «Long term hormone therapy for perimenopausal and postmenopausal women». Cochrane Database Syst Rev, 2, 15-04-2009, pàg. CD004143. DOI: 10.1002/14651858.CD004143.pub3. PMID: 19370593.
Barrett-Connor, E; Laughlin, GA «Endogenous and exogenous estrogen, cognitive function, and dementia in postmenopausal women: evidence from epidemiologic studies and clinical trials». Semin Reprod Med, 27, 3, 5-2009, pàg. 275–82. DOI: 10.1055/s-0029-1216280. PMC: 2701737. PMID: 19401958.
Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M «Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study». J Alzheimers Dis, 16, 1, gener 2009, pàg. 85–91. PMID: 19158424.
Paradise M, Cooper C, Livingston G «Systematic review of the effect of education on survival in Alzheimer's disease». Int Psychogeriatr, 21, 1, febrer 2009, pàg. 25–32. DOI: 10.1017/S1041610208008053. PMID: 19026089.
Shcherbatykh I, Carpenter DO «The role of metals in the etiology of Alzheimer's disease». J Alzheimers Dis, 11, 2, maig 2007, pàg. 191–205. PMID: 17522444.
Rondeau V, Commenges D, Jacqmin-Gadda H, Dartigues JF «Relation between aluminum concentrations in drinking water and Alzheimer's disease: an 8-year follow-up study». Am J Epidemiol, 152, 1, juliol 2000, pàg. 59–66. DOI: 10.1093/aje/152.1.59. PMC: 2215380. PMID: 10901330.
Kukull WA, Larson EB, Bowen JD, et al. «Solvent exposure as a risk factor for Alzheimer's disease: a case-control study». Am J Epidemiol, 141, 11, juny 1995, pàg. 1059–71; discussion 1072–9. PMID: 7771442.
Santibáñez M, Bolumar F, García AM «Occupational risk factors in Alzheimer's disease: a review assessing the quality of published epidemiological studies». Occupational and Environmental Medicine, 64, 11, 2007, pàg. 723–732. DOI: 10.1136/oem.2006.028209. PMID: 17525096.
Seidler A, Geller P, Nienhaus A, et al. «Occupational exposure to low frequency magnetic fields and dementia: a case-control study». Occup Environ Med, 64, 2, febrer 2007, pàg. 108–14. DOI: 10.1136/oem.2005.024190. PMID: 17043077.
Rondeau V «A review of epidemiologic studies on aluminum and silica in relation to Alzheimer's disease and associated disorders». Rev Environ Health, 17, 2, 2002, pàg. 107–21. PMID: 12222737.
Martyn CN, Coggon DN, Inskip H, Lacey RF, Young WF «Aluminum concentrations in drinking water and risk of Alzheimer's disease». Epidemiology, 8, 3, maig 1997, pàg. 281–6. DOI: 10.1097/00001648-199705000-00009. PMID: 9115023.
Graves AB, Rosner D, Echeverria D, Mortimer JA, Larson EB «Occupational exposures to solvents and aluminium and estimated risk of Alzheimer's disease». Occup Environ Med, 55, 9, setembre 1998, pàg. 627–33. DOI: 10.1136/oem.55.9.627. PMC: 1757634. PMID: 9861186.
Hug, K; Röösli, M & Rapp, R «Magnetic field exposure and neurodegenerative diseases--recent epidemiological studies». Sozial- und Praventivmedizin, 51, 4, 2006, pàg. 210–20. DOI: 10.1007/s00038-006-5096-4. PMID: 17193783.
Hardell, L; Sage, C «Biological effects from electromagnetic field exposure and public exposure standards». Biomedicine & pharmacotherapy, 62, 2, Feb 2008, pàg. 104–9. DOI: 10.1016/j.biopha.2007.12.004. PMID: 18242044.
Davanipour, Z; Sobel, E «Long-term exposure to magnetic fields and the risks of Alzheimer's disease and breast cancer: Further biological research». Pathophysiology, ISP 16, 2-3, Aug 2009, pàg. 149–56. DOI: 10.1016/j.pathophys.2009.01.005. PMID: 19278839.
Kheifets, L; Bowman, Jd et al. «Future needs of occupational epidemiology of extremely low frequency electric and magnetic fields: review and recommendations». Occupational and environmental medicine, 66, 2, Feb 2009, pàg. 72–80. DOI: 10.1136/oem.2007.037994. PMID: 18805878.
Geula C, Mesulam MM «Cholinesterases and the pathology of Alzheimer disease». Alzheimer Dis Assoc Disord, 9 Suppl 2, 1995, pàg. 23–28. PMID: 8534419.
Stahl SM «The new cholinesterase inhibitors for Alzheimer's disease, Part 2: illustrating their mechanisms of action». J Clin Psychiatry, 61, 11, 2000, pàg. 813–814. PMID: 11105732.
Raina P, Santaguida P, Ismaila A, et al. «Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline». Annals of Internal Medicine, 148, 5, 2008, pàg. 379–397. PMID: 18316756.
Antipsychotics use:
Ballard C, Waite J «The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease». Cochrane Database Syst Rev, 1, 2006, pàg. CD003476. DOI: 10.1002/14651858.CD003476.pub2. PMID: 16437455.
Ballard C, Hanney ML, Theodoulou M, Douglas S, McShane R, Kossakowski K, Gill R, Juszczak E, Yu L-M, Jacoby R «The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial». Lancet Neurology, 8, 2, 09-01-2009, pàg. 151. DOI: 10.1016/S1474-4422(08)70295-3. PMID: 19138567.
Bottino CM, Carvalho IA, Alvarez AM, et al. «Cognitive rehabilitation combined with drug treatment in Alzheimer's disease patients: a pilot study». Clin Rehabil, 19, 8, 2005, pàg. 861–869. DOI: 10.1191/0269215505cr911oa. PMID: 16323385.
Doody RS, Stevens JC, Beck C, et al. «Practice parameter: management of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology». Neurology, 56, 9, 2001, pàg. 1154–1166. PMID: 11342679.
Hermans DG, Htay UH, McShane R «Non-pharmacological interventions for wandering of people with dementia in the domestic setting». Cochrane Database Syst Rev, 1, 2007, pàg. CD005994. DOI: 10.1002/14651858.CD005994.pub2. PMID: 17253573.
Robinson L, Hutchings D, Dickinson HO, et al. «Effectiveness and acceptability of non-pharmacological interventions to reduce wandering in dementia: a systematic review». Int J Geriatr Psychiatry, 22, 1, 2007, pàg. 9–22. DOI: 10.1002/gps.1643. PMID: 17096455.
Chung JC, Lai CK, Chung PM, French HP «Snoezelen for dementia». Cochrane Database Syst Rev, 4, 2002, pàg. CD003152. DOI: 10.1002/14651858.CD003152. PMID: 12519587.
Woods B, Spector A, Jones C, Orrell M, Davies S «Reminiscence therapy for dementia». Cochrane Database Syst Rev, 2, 2005, pàg. CD001120. DOI: 10.1002/14651858.CD001120.pub2. PMID: 15846613.
Zetteler J «Effectiveness of simulated presence therapy for individuals with dementia: a systematic review and meta-analysis». Aging Ment Health, 12, 6, novembre 2008, pàg. 779–85. DOI: 10.1080/13607860802380631. PMID: 19023729.
Spector A, Orrell M, Davies S, Woods B «Withdrawn: Reality orientation for dementia». Cochrane Database Syst Rev, 3, 2000, pàg. CD001119. DOI: 10.1002/14651858.CD001119.pub2. PMID: 17636652.
Spector A, Thorgrimsen L, Woods B, et al. «Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial». Br J Psychiatry, 183, 2003, pàg. 248–254. DOI: 10.1192/bjp.183.3.248. PMID: 12948999.
Gitlin LN, Hauck WW, Dennis MP, Winter L «Maintenance of effects of the home environmental skill-building program for family caregivers and individuals with Alzheimer's disease and related disorders». J. Gerontol. A Biol. Sci. Med. Sci., 60, 3, març 2005, pàg. 368–74. PMID: 15860476.
Dunne TE, Neargarder SA, Cipolloni PB, Cronin-Golomb A «Visual contrast enhances food and liquid intake in advanced Alzheimer's disease». Clinical Nutrition, 23, 4, 2004, pàg. 533–538. DOI: 10.1016/j.clnu.2003.09.015. PMID: 15297089.
Dennehy C «Analysis of patients' rights: dementia and PEG insertion». Br J Nurs, 15, 1, 2006, pàg. 18–20. PMID: 16415742.
Gambassi G, Landi F, Lapane KL, Sgadari A, Mor V, Bernabei R «Predictors of mortality in patients with Alzheimer's disease living in nursing homes». J. Neurol. Neurosurg. Psychiatr., 67, 1, juliol 1999, pàg. 59–65. DOI: 10.1136/jnnp.67.1.59. PMC: 1736445. PMID: 10369823.
Shega JW, Levin A, Hougham GW, et al. «Palliative Excellence in Alzheimer Care Efforts (PEACE): a program description». J Palliat Med, 6, 2, abril 2003, pàg. 315–20. DOI: 10.1089/109662103764978641. PMID: 12854952.
Mitchell SL, Teno JM, Kiely DK, et al. «The clinical course of advanced dementia». N Engl J Med, 361, 16, Oct 2009, pàg. 1529–38. PMID: 19828530.
Bowen JD, Malter AD, Sheppard L, et al. «Predictors of mortality in patients diagnosed with probable Alzheimer's disease». Neurology, 47, 2, agost 1996, pàg. 433–9. PMID: 8757016.
Dodge HH, Shen C, Pandav R, DeKosky ST, Ganguli M «Functional transitions and active life expectancy associated with Alzheimer disease». Arch. Neurol., 60, 2, febrer 2003, pàg. 253–9. DOI: 10.1001/archneur.60.2.253. PMID: 12580712.
Larson EB, Shadlen MF, Wang L, et al. «Survival after initial diagnosis of Alzheimer disease». Ann. Intern. Med., 140, 7, abril 2004, pàg. 501–9. PMID: 15068977.
Jagger C, Clarke M, Stone A «Predictors of survival with Alzheimer's disease: a community-based study». Psychol Med, 25, 1, gener 1995, pàg. 171–7. DOI: 10.1017/S0033291700028191. PMID: 7792352.
Ganguli M, Dodge HH, Shen C, Pandav RS, DeKosky ST «Alzheimer disease and mortality: a 15-year epidemiological study». Arch. Neurol., 62, 5, maig 2005, pàg. 779–84. DOI: 10.1001/archneur.62.5.779. PMID: 15883266.
Bermejo-Pareja F, Benito-León J, Vega S, Medrano MJ, Román GC «Incidence and subtypes of dementia in three elderly populations of central Spain». J. Neurol. Sci., 264, 1–2, gener 2008, pàg. 63–72. DOI: 10.1016/j.jns.2007.07.021. PMID: 17727890.
Di Carlo A, Baldereschi M, Amaducci L, et al. «Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study». J Am Geriatr Soc, 50, 1, 2002, pàg. 41–8. DOI: 10.1046/j.1532-5415.2002.50006.x. PMID: 12028245.
Andersen K, Launer LJ, Dewey ME, et al. «Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group». Neurology, 53, 9, 1999, pàg. 1992–7. PMID: 10599770.
2000 U.S. estimates:
Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA «Alzheimer disease in the US population: prevalence estimates using the 2000 census». Arch. Neurol., 60, 8, 2003, pàg. 1119–22. DOI: 10.1001/archneur.60.8.1119. PMID: 12925369.
Bonin-Guillaume S, Zekry D, Giacobini E, Gold G, Michel JP «Impact économique de la démence (English: The economical impact of dementia)» (en francès). Presse Med, 34, 1, gener 2005, pàg. 35–41. ISSN: 0755-4982. PMID: 15685097.
Nikolaev, Anatoly; Todd McLaughlin, Dennis O'Leary, Marc Tessier-Lavigne «N-APP binds DR6 to cause axon pruning and neuron death via distinct caspases». Nature, 457, 7232, 19-02-2009, pàg. 981–989. DOI: 10.1038/nature07767. ISSN: 0028-0836. PMC: 2677572. PMID: 19225519 [Consulta: maig 2009].