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Jie Chen, Kaibo Mei, Lixia Xie, Ping Yuan, Jianyong Ma: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs. In: Nutrition Journal. Band20, Nr.1, 31. Oktober 2021, ISSN1475-2891, S.89, doi:10.1186/s12937-021-00744-y, PMID 34719404, PMC 8557713 (freier Volltext).
Andrew T. Levin, William P. Hanage, Nana Owusu-Boaitey, Kensington B. Cochran, Seamus P. Walsh, Gideon Meyerowitz-Katzcorresponding author: Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications. In: Eur J Epidemiol. 8. Dezember 2020, doi:10.1007/s10654-020-00698-1, PMID 33289900, PMC 7721859 (freier Volltext) – (springer.com [PDF] s. a. Supplementary file2 (XLSX 56 kB), Daten Diagramm aus Tabellenblatt „Metaregression Predictions“).: „The estimated age-specific IFR is very low for children and younger adults (e.g., 0.002% at age 10 and 0.01% at age 25) but increases progressively to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15 % at age 85. […] and exceeds 25 % for ages 90 and above. […] We obtain the following metaregression results: log10(IFR)=−3.27+0.0524∗age […] These results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults, for whom the infection fatality rate is two orders of magnitude greater than the annualized risk of a fatal automobile accident and far more dangerous than seasonal influenza. […] Consequently, public health measures to mitigate infections in older adults could substantially decrease total deaths.“
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Laura Semenzato et al. in The Lancet: Chronic diseases, health conditions and risk of COVID-19-related hospitalization and in-hospital mortality during the first wave of the epidemic in France: a cohort study of 66 million people. Research paper. In: Regional Health –- Europe. Band8. Elsevier, 16. Juli 2021, 100158, doi:10.1016/j.lanepe.2021.100158 (englisch, thelancet.com [PDF; 3,9MB; abgerufen am 9. September 2021] Diagramm-Daten: Table 2: Hospitalization with COVID-19): “Findings–- In a population of 66,050,090 people, 87,809 people (134 per 100,000) were hospitalized for COVID-19 between February 15, 2020 and June 15, 2020 and a subgroup of 15,661 people (24 per 100,000) died in hospital. A much higher risk was observed with increasing age, reaching a risk of hospitalization for COVID-19 more than five fold higher and a risk of COVID-19-related in-hospital mortality more than 100-fold higher in people aged 85 years and older (absolute risks of 750 and 268 per 100,000, respectively) compared to people aged 40 to 44 years. The strongest associations for both COVID-19-related hospitalization and in-hospital mortality were observed in people with Down syndrome […], mental retardation […], kid-ney transplantation […], lung transplantation […] end-stage renal disease on dialysis […] and active lung cancer […].”
V. O. Puntmann, M. L. Carerj, I. Wieters et al.: Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). In: JAMA Cardiology. Published online: 27. Juli 2020, doi:10.1001/jamacardio.2020.3557.
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Derek K. Chu, Elie A. Akl u. a.: Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. In: The Lancet. 1. Juni 2020, doi:10.1016/S0140-6736(20)31142-9.
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Patrick Hunziker: Minimizing exposure to respiratory droplets, ‘jet riders’ and aerosols in air-conditioned hospital rooms by a ‘Shield-and-Sink’ strategy. In: medRxiv. 16. Dezember 2020, doi:10.1101/2020.12.08.20233056 (medrxiv.org [abgerufen am 24. Dezember 2020]).
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Emmie de Wit,
Vincent J. Munster et al.: Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. In: NEJM, 16. April 2020, doi:10.1056/NEJMc2004973.
Jacob Burns u. a.: Reisebezogene Kontrollmaßnahmen zur Eindämmung der COVID‐19‐Pandemie: ein Rapid Review. In: Cochrane Database of Systematic Reviews. 16. September 2020, doi:10.1002/14651858.CD013717.
Meera Viswanathan u. a.: Universal screening for SARS‐CoV‐2 infection: a rapid review. In: Cochrane Database of Systematic Reviews. 15. September 2020, doi:10.1002/14651858.CD013718.
Barbara Nussbaumer-Streit u. a.: Quarantine alone or in combination with other public health measures to control COVID‐19: a rapid review. In: Cochrane Database of Systematic Reviews. 14. September 2020, doi:10.1002/14651858.CD013574.pub2.
Alba Mendez-Brito, Charbel El Bcheraoui, Francisco Pozo-Martin: Systematic review of empirical studies comparing the effectiveness of non-pharmaceutical interventions against COVID-19. In: Journal of Infection. Band83 (2021). Elsevier, 20. Juni 2021, S.281, 287–290, doi:10.1016/j.jinf.2021.06.018 (englisch, journalofinfection.com [PDF; 1,7MB; abgerufen am 31. August 2021]): “Early implementation was associated with a higher effectiveness in reducing COVID-19 cases and deaths, while general stringency of the NPIs was not. Conclusions: In this systematic review, we found that school closing, followed by workplace closing, business and venue closing and public event bans were the most effective NPIs in controlling the spread of COVID-19. […] Two health system measures found to be effective in reducing COVID-19 cases are public information campaigns and mask wearing requirements. […] In contrast, public transport closure, testing strategies, contact tracing strategies and isolation or quarantine strategies showed no evidence of being effective in the studies assessed. […] In conclusion, a cautious approach for reopening should be adapted to each context, with specific mitigation measures, stepwise opening and monitoring the effects of reopening for in-school and community transmission. […] The existence of super spreaders is considered to be a common characteristic of coronaviruses, and it is related with several factors, like prolonged indoor gatherings with poor ventilation. […] Regarding vaccine rollout, they considered that vaccination was increasingly contributing to the pandemic control, despite its effect having a significantly lower impact than the NPIs by the time of the study.”
Siri R. Kadire, Robert M. Wachter, Nicole Lurie: Delayed Second Dose versus Standard Regimen for Covid-19 Vaccination. In: New England Journal of Medicine. Band384, Nr.9, 4. März 2021, ISSN0028-4793, S.e28, doi:10.1056/NEJMclde2101987 (nejm.org [abgerufen am 17. August 2021]).
Patrick Hunziker: Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit. In: Precision Nanomedicine. Band4, Nr.3, 24. Juli 2021, S.805–820, doi:10.33218/001c.26101 (precisionnanomedicine.com [abgerufen am 17. August 2021]).
Harder T, Koch J, Vygen-Bonnet S, Scholz S, Pilic A, Reda S, Wichmann O: Wie gut schützt die COVID-19-Impfung vor SARS-CoV-2-Infektionen und SARS-CoV-2-Transmission? – Systematischer Review und Evidenzsynthese Epid Bull 2021;19:13 -23 | doi:10.25646/8442
Qiang Zhang et al.: A serological survey of SARS-CoV-2 in cat in Wuhan. In: Emerging Microbes & Infections. Band9, Nr.1, Januar 2020, S.2013–2019, doi:10.1080/22221751.2020.1817796, PMID 32867625, PMC 7534315 (freier Volltext): „Cat is susceptible to SARS-CoV-2. […] Our data demonstrated that SARS-CoV-2 has infected cats in Wuhan during the outbreak and described serum antibody dynamics in cats“
Jianzhong Shi et al.: Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2. In: Science.doi:10.1126/science.abb7015 (Volltext als PDF).
Die leitende Hebamme des englischen Gesundheitsdienstes NHS nahm den am 25. Juli erschienenen Preprint (siehe oben) zum Anlass, schwangere Frauen zum Impfen aufzurufen. In einem Brief (online) appellierte sie an Hebammen und Ärztinnen, Frauen zum Impfen zu ermutigen, um sich und ihr Baby zu schützen.
ersjournals.com
erj.ersjournals.com
James D. Chalmers, Megan L. Crichton, Pieter C. Goeminne, Bin Cao, Marc Humbert: Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline. In: European Respiratory Journal. Band57, Nr.4, April 2021, ISSN0903-1936, S.2100048, doi:10.1183/13993003.00048-2021, PMID 33692120, PMC 7947358 (freier Volltext) – (ersjournals.com [abgerufen am 3. Februar 2022]).
Tapiwa Ganyani et al. in Eurosurveillance: Estimating the generation interval for coronavirus disease (COVID-19) based on symptom onset data, March 2020. (PDF) In: 25(17):pii=2000257. eurosurveillance.org, 7. April 2020, abgerufen am 12. September 2021 (englisch): „As expected, the proportion of pre-symptomatic transmission increased from 48 % (95 % CrI: 32–67) in the baseline scenario to 66 % (95 % CrI: 45–84) when allowing for negative serial intervals, for the Singapore data, and from 62 % (95 % CrI: 50–76) to 77 % (95 % CrI: 65–87) for the Tianjin data. When the incubation period is larger, it is expected that these proportions will be higher and when it is smaller, they are expected to be lower. Hence, a large proportion of transmission appears to occur before symptom onset, which is an important point to consider when planning intervention strategies.“doi:10.2807/1560-7917.ES.2020.25.17.2000257, preprint war doi:10.1101/10.1101/2020.03.05.20031815
Launch of a European clinical trial against COVID-19. INSERM, 22. März 2020, abgerufen am 5. April 2020: „The great strength of this trial is its „adaptive“ nature. This means that ineffective experimental treatments can very quickly be dropped and replaced by other molecules that emerge from research efforts. We will therefore be able to make changes in real time, in line with the most recent scientific data, in order to find the best treatment for our patients“
jamanetwork.com
Valentina O. Puntmann, M. Ludovica Carerj, Imke Wieters, Masia Fahim, Christophe Arendt: Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). In: JAMA Cardiology. 27. Juli 2020, doi:10.1001/jamacardio.2020.3557 (online [abgerufen am 14. August 2020]).
Alba Mendez-Brito, Charbel El Bcheraoui, Francisco Pozo-Martin: Systematic review of empirical studies comparing the effectiveness of non-pharmaceutical interventions against COVID-19. In: Journal of Infection. Band83 (2021). Elsevier, 20. Juni 2021, S.281, 287–290, doi:10.1016/j.jinf.2021.06.018 (englisch, journalofinfection.com [PDF; 1,7MB; abgerufen am 31. August 2021]): “Early implementation was associated with a higher effectiveness in reducing COVID-19 cases and deaths, while general stringency of the NPIs was not. Conclusions: In this systematic review, we found that school closing, followed by workplace closing, business and venue closing and public event bans were the most effective NPIs in controlling the spread of COVID-19. […] Two health system measures found to be effective in reducing COVID-19 cases are public information campaigns and mask wearing requirements. […] In contrast, public transport closure, testing strategies, contact tracing strategies and isolation or quarantine strategies showed no evidence of being effective in the studies assessed. […] In conclusion, a cautious approach for reopening should be adapted to each context, with specific mitigation measures, stepwise opening and monitoring the effects of reopening for in-school and community transmission. […] The existence of super spreaders is considered to be a common characteristic of coronaviruses, and it is related with several factors, like prolonged indoor gatherings with poor ventilation. […] Regarding vaccine rollout, they considered that vaccination was increasingly contributing to the pandemic control, despite its effect having a significantly lower impact than the NPIs by the time of the study.”
Patrick Hunziker: Minimizing exposure to respiratory droplets, ‘jet riders’ and aerosols in air-conditioned hospital rooms by a ‘Shield-and-Sink’ strategy. In: medRxiv. 16. Dezember 2020, doi:10.1101/2020.12.08.20233056 (medrxiv.org [abgerufen am 25. Dezember 2020]).
Victor M. Corman, Verena Claudia Haage, Tobias Bleicker, Marie Luisa Schmidt, Barbara Mühlemann: Comparison of seven commercial SARS-CoV-2 rapid Point-of-Care Antigen tests. In: medRxiv. 13. November 2020, S.2020.11.12.20230292, doi:10.1101/2020.11.12.20230292 (medrxiv.org [abgerufen am 10. Dezember 2020]).
Hongchao Pan, Richard Peto, Quarraisha Abdool Karim, Marissa Alejandria, Ana Maria Henao Restrepo, Cesar Hernandez Garcia, Marie Paule Kieny, Reza Malekzadeh, Srinivas Murthy, Marie-Pierre Preziosi, Srinath Reddy, Mirta Roses, Vasee Sathiyamoorthy, John-Arne Rottingen, Soumya Swaminathan: Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results. Weltgesundheitsorganisation, 15. Oktober 2020, abgerufen am 15. Oktober 2020.
Patrick Hunziker: Minimizing exposure to respiratory droplets, ‘jet riders’ and aerosols in air-conditioned hospital rooms by a ‘Shield-and-Sink’ strategy. In: medRxiv. 16. Dezember 2020, doi:10.1101/2020.12.08.20233056 (medrxiv.org [abgerufen am 24. Dezember 2020]).
Bo Diao et al.: Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection. Open Access. In: Nature Communications. Band12, 4. Mai 2021, 2506, doi:10.1038/s41467-021-22781-1 (englisch, nature.com [PDF; 16,2MB; abgerufen am 12. September 2021]): “can directly infect human kidney, thus leading to acute kidney injury (AKI). […] retrospective analysis of clinical parameters from 85 patients with laboratory-confirmed coronavirus disease 2019 (COVID-19); moreover, kidney histopathology from six additional COVID-19 patients with post-mortem examinations was performed. We find that 27 % (23/85) of patients exhibited AKI. Haematoxylin & eosin staining shows that the kidneys from COVID-19 autopsies have moderate to severe tubular damage. In situ hybridization assays illustrate that viral RNA accumulates in tubules.”, preprint war doi:10.1101/2020.03.04.20031120
Roman Wölfel et al.: Virological assessment of hospitalized patients with COVID-2019. In: Nature. Band581, 1. April 2020, S.465–469, doi:10.1038/s41586-020-2196-x (englisch, nature.com [PDF; 3,1MB; abgerufen am 12. September 2021]): “Viral load also differs considerably between SARS and COVID-19. For SARS, it took 7 to 10 days after the onset of symptoms until peak RNA concentrations (of up to 5 x 105 copies per swab) were reached. In the present study, peak concentrations were reached before day 5, and were more than 1,000 times higher.”, preprint war doi:10.1101/2020.03.05.20030502
Hannah Peckhame et al.: Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. In: Nature Communications. Band11, Nr.1, 9. Dezember 2020, ISSN2041-1723, S.6317, doi:10.1038/s41467-020-19741-6 (nature.com [abgerufen am 7. Februar 2021]).
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Roman Wölfel, Victor M. Corman, Wolfgang Guggemos, Michael Seilmaier, Sabine Zange: Virological assessment of hospitalized patients with COVID-2019. In: Nature. 1. April 2020, ISSN1476-4687, S.1–10, doi:10.1038/s41586-020-2196-x (nature.com [abgerufen am 5. April 2020]).
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Fernando P. Polack et al.: Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. In: New England Journal of Medicine. 10. Dezember 2020, doi:10.1056/NEJMoa2034577, PMID 33301246, PMC 7745181 (freier Volltext) – (nejm.org [abgerufen am 24. Dezember 2020]).
Evan J. et al.: Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults. In: New England Journal of Medicine. 29. September 2020, doi:10.1056/NEJMoa2028436, PMID 32991794, PMC 7556339 (freier Volltext) – (nejm.org [abgerufen am 24. Dezember 2020]).
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F Tretter, EMJ Peters, J Sturmberg, J Bennett, E Voit, JW Dietrich, G Smith, W Weckwerth, Z Grossman, O Wolkenhauer, JA Marcum: Perspectives of (/memorandum for) systems thinking on COVID-19 pandemic and pathology. In: Journal of evaluation in clinical practice. 28. September 2022, doi:10.1111/jep.13772, PMID 36168893.
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Patrícia O. Guimarães, Daniel Quirk, Remo H. Furtado, Lilia N. Maia, José F. Saraiva: Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia. In: New England Journal of Medicine. Band385, Nr.5, 29. Juli 2021, ISSN0028-4793, S.406–415, doi:10.1056/NEJMoa2101643, PMID 34133856, PMC 8220898 (freier Volltext).
Andreas Neubauer, Thomas Wiesmann, Claus F. Vogelmeier, Elisabeth Mack, Chrysanthi Skevaki: Ruxolitinib for the treatment of SARS-CoV-2 induced acute respiratory distress syndrome (ARDS). In: Leukemia. Band34, Nr.8, August 2020, ISSN0887-6924, S.2276–2278, doi:10.1038/s41375-020-0907-9, PMID 32555296, PMC 7298698 (freier Volltext).
James D. Chalmers, Megan L. Crichton, Pieter C. Goeminne, Bin Cao, Marc Humbert: Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline. In: European Respiratory Journal. Band57, Nr.4, April 2021, ISSN0903-1936, S.2100048, doi:10.1183/13993003.00048-2021, PMID 33692120, PMC 7947358 (freier Volltext) – (ersjournals.com [abgerufen am 3. Februar 2022]).
Julia Kristin Stroehlein et al.: Vitamin D supplementation for the treatment of COVID-19: a living systematic review. In: The Cochrane Database of Systematic Reviews. Band5, 24. Mai 2021, S.CD015043, doi:10.1002/14651858.CD015043, PMID 34029377.
Jie Chen, Kaibo Mei, Lixia Xie, Ping Yuan, Jianyong Ma: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs. In: Nutrition Journal. Band20, Nr.1, 31. Oktober 2021, ISSN1475-2891, S.89, doi:10.1186/s12937-021-00744-y, PMID 34719404, PMC 8557713 (freier Volltext).
Andrew T. Levin, William P. Hanage, Nana Owusu-Boaitey, Kensington B. Cochran, Seamus P. Walsh, Gideon Meyerowitz-Katzcorresponding author: Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications. In: Eur J Epidemiol. 8. Dezember 2020, doi:10.1007/s10654-020-00698-1, PMID 33289900, PMC 7721859 (freier Volltext) – (springer.com [PDF] s. a. Supplementary file2 (XLSX 56 kB), Daten Diagramm aus Tabellenblatt „Metaregression Predictions“).: „The estimated age-specific IFR is very low for children and younger adults (e.g., 0.002% at age 10 and 0.01% at age 25) but increases progressively to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15 % at age 85. […] and exceeds 25 % for ages 90 and above. […] We obtain the following metaregression results: log10(IFR)=−3.27+0.0524∗age […] These results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults, for whom the infection fatality rate is two orders of magnitude greater than the annualized risk of a fatal automobile accident and far more dangerous than seasonal influenza. […] Consequently, public health measures to mitigate infections in older adults could substantially decrease total deaths.“
Qiang Zhang et al.: A serological survey of SARS-CoV-2 in cat in Wuhan. In: Emerging Microbes & Infections. Band9, Nr.1, Januar 2020, S.2013–2019, doi:10.1080/22221751.2020.1817796, PMID 32867625, PMC 7534315 (freier Volltext): „Cat is susceptible to SARS-CoV-2. […] Our data demonstrated that SARS-CoV-2 has infected cats in Wuhan during the outbreak and described serum antibody dynamics in cats“
Andres Wysling, Rom: Spitäler in Norditalien nah am Kollaps – keine Intensivpflege für alte Patienten mehr? In: Neue Zürcher Zeitung. (nzz.ch [abgerufen am 12. März 2020]).
Jetzt der Grippe zuvorkommen – mit der Grippeschutzimpfung! (Stand: 10. Oktober 2021). In: PEU-Website.Paul-Ehrlich-Institut (PEI), 6. Oktober 2021, abgerufen am 11. Oktober 2021 („Im Herbst 2021 ist die Grippeschutzimpfung vor dem Hintergrund der Corona-Pandemie besonders wichtig. Das Bundesministerium für Gesundheit (BMG), die Bundeszentrale für gesundheitliche Aufklärung (BZgA), das Robert Koch-Institut (RKI) und das Paul-Ehrlich-Institut (PEI) rufen daher insbesondere Menschen mit einem erhöhten Risiko für den schweren Verlauf einer Grippe auf, sich jetzt impfen zu lassen.“ → Quelle: ebenda).
Christina Hohmann-Jeddi: Covid-19-Impfung: EMA spricht sich für Auffrischung mit Spikevax aus. In: Pharmazeutische Zeitung (PZ). 26. Oktober 2021, abgerufen am 27. Oktober 2021 („Die Europäische Arzneimittelagentur spricht sich für eine Auffrischungsimpfung mit dem Coronaimpfstoff Spikevax® von Moderna aus. Für Erwachsene könne eine Boosterdosis erwogen werden, teilte die Behörde am Montag [25. Oktober 2021] mit.“ → Quelle: ebenda).
Patrick Hunziker: Personalized-dose Covid-19 vaccination in a wave of virus Variants of Concern: Trading individual efficacy for societal benefit. In: Precision Nanomedicine. Band4, Nr.3, 24. Juli 2021, S.805–820, doi:10.33218/001c.26101 (precisionnanomedicine.com [abgerufen am 17. August 2021]).
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Jianpeng Xiao et al. in International Journal of Infectious Diseases: The time-varying transmission dynamics of COVID-19 and synchronous public health interventions in China. In: International Journal for Infectious Diseases. Band103. Elsevier, Februar 2021, S.617–623, doi:10.1016/j.ijid.2020.11.005 (englisch, sciencedirect.com [PDF; 1,4MB; abgerufen am 12. September 2021]): “As of 20 March 2020, 80,739 locally acquired COVID-19 cases were identified in mainland China, with most cases reported between 20 January and 29 February 2020. The R0 value of COVID-19 in China and Wuhan was 5.0 and 4.8, respectively, which was greater than the R0 value of SARS in Guangdong (R0 = 2.3), Hong Kong (R0 = 2.3), and Beijing (R0 = 2.6).”, preprint war doi:10.1101/2020.01.25.919787
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Andrew T. Levin, William P. Hanage, Nana Owusu-Boaitey, Kensington B. Cochran, Seamus P. Walsh, Gideon Meyerowitz-Katzcorresponding author: Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications. In: Eur J Epidemiol. 8. Dezember 2020, doi:10.1007/s10654-020-00698-1, PMID 33289900, PMC 7721859 (freier Volltext) – (springer.com [PDF] s. a. Supplementary file2 (XLSX 56 kB), Daten Diagramm aus Tabellenblatt „Metaregression Predictions“).: „The estimated age-specific IFR is very low for children and younger adults (e.g., 0.002% at age 10 and 0.01% at age 25) but increases progressively to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15 % at age 85. […] and exceeds 25 % for ages 90 and above. […] We obtain the following metaregression results: log10(IFR)=−3.27+0.0524∗age […] These results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults, for whom the infection fatality rate is two orders of magnitude greater than the annualized risk of a fatal automobile accident and far more dangerous than seasonal influenza. […] Consequently, public health measures to mitigate infections in older adults could substantially decrease total deaths.“
static-content.springer.com
Andrew T. Levin, William P. Hanage, Nana Owusu-Boaitey, Kensington B. Cochran, Seamus P. Walsh, Gideon Meyerowitz-Katzcorresponding author: Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications. In: Eur J Epidemiol. 8. Dezember 2020, doi:10.1007/s10654-020-00698-1, PMID 33289900, PMC 7721859 (freier Volltext) – (springer.com [PDF] s. a. Supplementary file2 (XLSX 56 kB), Daten Diagramm aus Tabellenblatt „Metaregression Predictions“).: „The estimated age-specific IFR is very low for children and younger adults (e.g., 0.002% at age 10 and 0.01% at age 25) but increases progressively to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15 % at age 85. […] and exceeds 25 % for ages 90 and above. […] We obtain the following metaregression results: log10(IFR)=−3.27+0.0524∗age […] These results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults, for whom the infection fatality rate is two orders of magnitude greater than the annualized risk of a fatal automobile accident and far more dangerous than seasonal influenza. […] Consequently, public health measures to mitigate infections in older adults could substantially decrease total deaths.“
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