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J. P. de Magalhaes, D. Wuttke, S. H. Wood, M. Plank, C. Vora: Genome-environment interactions that modulate aging: powerful targets for drug discovery. In: Pharmacol Rev. Band64, Nr.1, 2012, S.88–101, doi:10.1124/pr.110.004499, PMID 22090473, PMC 3250080 (freier Volltext).
D. K. Ingram, G. S. Roth: Glycolytic inhibition as a strategy for developing calorie restriction mimetics. In: Experimental Gerontology. Band46, Nr.2–3 (Feb–Mar), 2011, S.148–154, doi:10.1016/j.exger.2010.12.001, PMID 21167272.
M. A. Lane, D. K. Ingram, G. S. Roth: 2-Deoxy-D-glucose feeding in rats mimics physiologic effects of calorie restriction. In: J Anti-Aging Med. Band1, Nr.4 (Winter), 1998, S.327–337, doi:10.1089/rej.1.1998.1.327.
Frank Madeo, Tobias Eisenberg, Federico Pietrocola, Guido Kroemer: Spermidine in health and disease. In: Science. Band359/6374, 26. Januar 2018, doi:10.1126/science.aan2788, PMID 29371440.
S. Kiechl, R. Pechlaner, P. Willeit, M. Notdurfter, B. Paulweber, K. Willeit, P. Werner, C. Ruckenstuhl, B. Iglseder, S. Weger, B. Mairhofer, M. Gartner, L. Kedenko, M. Chmelikova, S. Stekovic, H. Stuppner, F. Oberhollenzer, G. Kroemer, M. Mayr, T. Eisenberg, H. Tilg, F. Madeo, J. Willeit: Higher spermidine intake is linked to lower mortality: a prospective population-based study. In: The American Journal of Clinical Nutrition. Band108, Nr.2, August 2018, S.371–380, doi:10.1093/ajcn/nqy102, PMID 29955838.
Claudia Schwarz u. a.: Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. In: US National Library of Medecine. National Institutes of Health (Hrsg.): Aging (Albany NY). Band10/1, 10. Januar 2018, S.19–33, doi:10.18632/aging.101354, PMID 29315079.
T. M. Bass, D. Weinkove, K. Houthoofd, D. Gems, L. Partridge: Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. In: Mech. Ageing Dev. Band128, Nr.10, Oktober 2007, S.546–552, doi:10.1016/j.mad.2007.07.007, PMID 17875315.
Matt Kaeberlein, Thomas McDonagh, Birgit Heltweg, Jeffrey Hixon, Eric A. Westman, Seth D. Caldwell, Andrew Napper, Rory Curtis, Peter S. DiStefano, Stanley Fields, Antonio Bedalov, Brian K. Kennedy: Substrate specific activation of sirtuins by resveratrol. In: Journal of Biological Chemistry. Band280, Nr.17, 29. April 2005, S.17038–17045, doi:10.1074/jbc.M500655200, PMID 15684413 (jbc.org [abgerufen am 7. September 2013]).
S. Zou, J. R. Carey, P. Liedo, D. K. Ingram, H. G. Müller, J. L. Wang, F. Yao, B. Yu, A. Zhou: The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. In: Experimental Gerontology. Band44, Nr.6–7 (Jun–Jul), 2009, S.472–476, doi:10.1016/j.exger.2009.02.011, PMID 19264118, PMC 3044489 (freier Volltext).
K. J. Pearson, J. A. Baur, K. N. Lewis, L. Peshkin, N. L. Price, N. Labinskyy, W. R. Swindell, D. Kamara, R. K. Minor, E. Perez, H. A. Jamieson, Y. Zhang, S. R. Dunn, K. Sharma, N. Pleshko, L. A. Woollett, A. Csiszar, Y. Ikeno, D. Le Couteur, P. J. Elliott, K. G. Becker, P. Navas, D. K. Ingram, N. S. Wolf, Z. Ungvari, D. A. Sinclair, R. de Cabo: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. In: Cell Metab. Band8, Nr.2, August 2008, S.157–168, doi:10.1016/j.cmet.2008.06.011, PMID 18599363, PMC 2538685 (freier Volltext).
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Randy Strong, Richard A. Miller, Clinton M. Astle, Joseph A. Baur, Rafael de Cabo, Elizabeth Fernandez, Wen Guo, Martin Javors, James L. Kirkland, James F. Nelson, David A. Sinclair, Bruce Teter, David Williams, Nurulain Zaveri, Nancy L. Nadon, David E. Harrison: Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice. In: J Gerontol A Biol Sci Med Sci. Band68, Nr.1, Januar 2013, S.6–16, doi:10.1093/gerona/gls070, PMID 22451473, PMC 3598361 (freier Volltext).
P. L. da Luz, L. Tanaka, P. C. Brum, P. M. Dourado, D. Favarato, J. E. Krieger, F. R. Laurindo: Red wine and equivalent oral pharmacological doses of Resveratrol delay vascular aging but do not extend life span in rats. In: Atherosclerosis. Band224, Nr.1, September 2012, S.136–142, doi:10.1016/j.atherosclerosis.2012.06.007, PMID 22818625.
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A. Martin-Montalvo, E. M. Mercken, S. J. Mitchell, H. H. Palacios, P. L. Mote, M. Scheibye-Knudsen, A. P. Gomes, T. M. Ward, R. K. Minor, M. J. Blouin, M. Schwab, M. Pollak, Y. Zhang, Y. Yu, K. G. Becker, V. A. Bohr, D. K. Ingram, D. A. Sinclair, N. S. Wolf, S. R. Spindler, M. Bernier, R. de Cabo: Metformin improves healthspan and lifespan in mice. In: Nature Communications. Band4, 31. Juli 2013, S.2192, doi:10.1038/ncomms3192, PMID 23900241, PMC 3736576 (freier Volltext).
D. L. Smith Jr, C. F. Elam Jr, J. A. Mattison, M. A. Lane, G. S. Roth, D. K. Ingram, D. B. Allison: Metformin supplementation and life span in Fischer-344 rats. In: J Gerontol A Biol Sci Med Sci. Band65, Nr.5, Mai 2010, S.468–474, doi:10.1093/gerona/glq033, PMID 20304770.
D. S. Williams, A. Cash, L. Hamadani, T. Diemer: Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. In: Aging Cell. Band8, Nr.6, 2009, S.765–768, doi:10.1111/j.1474-9726.2009.00527.x, PMID 19793063.
J. M. Haslam, H. A. Krebs: The permeabiliity of mitochondria to oxaloacetate and malate. In: Biochem J. Band107, Nr.5, 1968, S.659–667, doi:10.1042/bj1070659, PMID 16742587.
R. K. Minor, D. L. Smith, A. M. Sossong, S. Kaushik, S. Poosala, E. L. Spangler, G. S. Roth, M. Lane, D. B. Allison, R. de Cabo, D. K. Ingram, J. A. Mattison: Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. In: Toxicol Appl Pharmacol. Band243, Nr.3, 15. März 2010, S.332–339, doi:10.1016/j.taap.2009.11.025, PMID 20026095, PMC 2830378 (freier Volltext).
T. J. Schulz, K. Zarse, A. Voigt, N. Urban, M. Birringer, M. Ristow: Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. In: Cell Metab. Band6, Nr.4, 2007, S.280–293, doi:10.1016/j.cmet.2007.08.011, PMID 17908557.
M. N. Stanfel, L. S. Shamieh, M. Kaeberlein, B. K. Kennedy: The TOR pathway comes of age. In: Biochim Biophys Acta. Band1790, Nr.10, Oktober 2009, S.1067–1074, doi:10.1016/j.bbagen.2009.06.007, PMID 19539012, PMC 3981532 (freier Volltext).
R. A. Miller, D. E. Harrison, C. M. Astle, E. Fernandez, K. Flurkey, M. Han, M. A. Javors, X. Li, N. L. Nadon, J. F. Nelson, S. Pletcher, A. B. Salmon, Z. D. Sharp, S. Van Roekel, L. Winkleman, R. Strong: Rapamycin-Mediated Lifespan Increase in Mice is Dose and Sex-Dependent and Appears Metabolically Distinct from Dietary Restriction. In: Aging Cell. Band13, Nr.3, Juni 2014, S.468–477, doi:10.1111/acel.12194, PMID 24341993, PMC 4032600 (freier Volltext).
Z. Yu, R. Wang, W. C. Fok, A. Coles, A. B. Salmon, V. I. Pérez: Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver. In: J Gerontol A Biol Sci Med Sci. Band70, Nr.4, April 2014, S.410–420, doi:10.1093/gerona/glu053, PMID 24755936.
W. C. Fok, A. Bokov, J. Gelfond, Z. Yu, Y. Zhang, M. Doderer, Y. Chen, M. Javors, W. H. Wood, Y. Zhang, K. G. Becker, A. Richardson, V. I. Pérez: Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. In: Aging Cell. Band13, Nr.2, April 2014, S.311–319, doi:10.1111/acel.12175, PMID 24304444.
Matt Kaeberlein, Thomas McDonagh, Birgit Heltweg, Jeffrey Hixon, Eric A. Westman, Seth D. Caldwell, Andrew Napper, Rory Curtis, Peter S. DiStefano, Stanley Fields, Antonio Bedalov, Brian K. Kennedy: Substrate specific activation of sirtuins by resveratrol. In: Journal of Biological Chemistry. Band280, Nr.17, 29. April 2005, S.17038–17045, doi:10.1074/jbc.M500655200, PMID 15684413 (jbc.org [abgerufen am 7. September 2013]).
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Sibylle Nikolai, Kathrin Pallauf, Patricia Huebbe, Gerald Rimbach: Energy restriction and potential energy restriction mimetics. In: Nutrition Research Reviews. Band28, Nr.2, Dezember 2015, S.1–21, doi:10.1017/S0954422415000062, PMID 26391585.
J. P. de Magalhaes, D. Wuttke, S. H. Wood, M. Plank, C. Vora: Genome-environment interactions that modulate aging: powerful targets for drug discovery. In: Pharmacol Rev. Band64, Nr.1, 2012, S.88–101, doi:10.1124/pr.110.004499, PMID 22090473, PMC 3250080 (freier Volltext).
D. K. Ingram, G. S. Roth: Glycolytic inhibition as a strategy for developing calorie restriction mimetics. In: Experimental Gerontology. Band46, Nr.2–3 (Feb–Mar), 2011, S.148–154, doi:10.1016/j.exger.2010.12.001, PMID 21167272.
Frank Madeo, Tobias Eisenberg, Federico Pietrocola, Guido Kroemer: Spermidine in health and disease. In: Science. Band359/6374, 26. Januar 2018, doi:10.1126/science.aan2788, PMID 29371440.
S. Kiechl, R. Pechlaner, P. Willeit, M. Notdurfter, B. Paulweber, K. Willeit, P. Werner, C. Ruckenstuhl, B. Iglseder, S. Weger, B. Mairhofer, M. Gartner, L. Kedenko, M. Chmelikova, S. Stekovic, H. Stuppner, F. Oberhollenzer, G. Kroemer, M. Mayr, T. Eisenberg, H. Tilg, F. Madeo, J. Willeit: Higher spermidine intake is linked to lower mortality: a prospective population-based study. In: The American Journal of Clinical Nutrition. Band108, Nr.2, August 2018, S.371–380, doi:10.1093/ajcn/nqy102, PMID 29955838.
Claudia Schwarz u. a.: Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. In: US National Library of Medecine. National Institutes of Health (Hrsg.): Aging (Albany NY). Band10/1, 10. Januar 2018, S.19–33, doi:10.18632/aging.101354, PMID 29315079.
T. M. Bass, D. Weinkove, K. Houthoofd, D. Gems, L. Partridge: Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. In: Mech. Ageing Dev. Band128, Nr.10, Oktober 2007, S.546–552, doi:10.1016/j.mad.2007.07.007, PMID 17875315.
Matt Kaeberlein, Thomas McDonagh, Birgit Heltweg, Jeffrey Hixon, Eric A. Westman, Seth D. Caldwell, Andrew Napper, Rory Curtis, Peter S. DiStefano, Stanley Fields, Antonio Bedalov, Brian K. Kennedy: Substrate specific activation of sirtuins by resveratrol. In: Journal of Biological Chemistry. Band280, Nr.17, 29. April 2005, S.17038–17045, doi:10.1074/jbc.M500655200, PMID 15684413 (jbc.org [abgerufen am 7. September 2013]).
S. Zou, J. R. Carey, P. Liedo, D. K. Ingram, H. G. Müller, J. L. Wang, F. Yao, B. Yu, A. Zhou: The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. In: Experimental Gerontology. Band44, Nr.6–7 (Jun–Jul), 2009, S.472–476, doi:10.1016/j.exger.2009.02.011, PMID 19264118, PMC 3044489 (freier Volltext).
K. J. Pearson, J. A. Baur, K. N. Lewis, L. Peshkin, N. L. Price, N. Labinskyy, W. R. Swindell, D. Kamara, R. K. Minor, E. Perez, H. A. Jamieson, Y. Zhang, S. R. Dunn, K. Sharma, N. Pleshko, L. A. Woollett, A. Csiszar, Y. Ikeno, D. Le Couteur, P. J. Elliott, K. G. Becker, P. Navas, D. K. Ingram, N. S. Wolf, Z. Ungvari, D. A. Sinclair, R. de Cabo: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. In: Cell Metab. Band8, Nr.2, August 2008, S.157–168, doi:10.1016/j.cmet.2008.06.011, PMID 18599363, PMC 2538685 (freier Volltext).
R. A. Miller, D. E. Harrison, C. M. Astle, J. A. Baur, A. R. Boyd, R. de Cabo, E. Fernandez, K. Flurkey, M. A. Javors, J. F. Nelson, C. J. Orihuela, S. Pletcher, Z. D. Sharp, D. Sinclair, J. W. Starnes, J. E. Wilkinson, N. L. Nadon, R. Strong: Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. In: J. Gerontol. A Biol. Sci. Med. Sci. Band66, Nr.2, Februar 2011, S.191–201, doi:10.1093/gerona/glq178, PMID 20974732, PMC 3021372 (freier Volltext).
Randy Strong, Richard A. Miller, Clinton M. Astle, Joseph A. Baur, Rafael de Cabo, Elizabeth Fernandez, Wen Guo, Martin Javors, James L. Kirkland, James F. Nelson, David A. Sinclair, Bruce Teter, David Williams, Nurulain Zaveri, Nancy L. Nadon, David E. Harrison: Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice. In: J Gerontol A Biol Sci Med Sci. Band68, Nr.1, Januar 2013, S.6–16, doi:10.1093/gerona/gls070, PMID 22451473, PMC 3598361 (freier Volltext).
P. L. da Luz, L. Tanaka, P. C. Brum, P. M. Dourado, D. Favarato, J. E. Krieger, F. R. Laurindo: Red wine and equivalent oral pharmacological doses of Resveratrol delay vascular aging but do not extend life span in rats. In: Atherosclerosis. Band224, Nr.1, September 2012, S.136–142, doi:10.1016/j.atherosclerosis.2012.06.007, PMID 22818625.
J. M. Dhahbi, P. L. Mote, G. M. Fahy, S. R. Spindler: Identification of potential caloric restriction mimetics by microarray profiling. In: Physiol Genomics. Band23, Nr.3, 17. November 2005, S.343–350, doi:10.1152/physiolgenomics.00069.2005, PMID 16189280.
A. V. Arkad'eva, A. A. Mamonov, I. G. Popovich, V. N. Anisimov, V. M. Mikhel'son, I. M. Spivak: Metformin slows down ageing processes at the cellular level in SHR mice. In: Tsitologiia. Band53, Nr.2, 2011, S.166–174, PMID 21516824.
A. Martin-Montalvo, E. M. Mercken, S. J. Mitchell, H. H. Palacios, P. L. Mote, M. Scheibye-Knudsen, A. P. Gomes, T. M. Ward, R. K. Minor, M. J. Blouin, M. Schwab, M. Pollak, Y. Zhang, Y. Yu, K. G. Becker, V. A. Bohr, D. K. Ingram, D. A. Sinclair, N. S. Wolf, S. R. Spindler, M. Bernier, R. de Cabo: Metformin improves healthspan and lifespan in mice. In: Nature Communications. Band4, 31. Juli 2013, S.2192, doi:10.1038/ncomms3192, PMID 23900241, PMC 3736576 (freier Volltext).
D. L. Smith Jr, C. F. Elam Jr, J. A. Mattison, M. A. Lane, G. S. Roth, D. K. Ingram, D. B. Allison: Metformin supplementation and life span in Fischer-344 rats. In: J Gerontol A Biol Sci Med Sci. Band65, Nr.5, Mai 2010, S.468–474, doi:10.1093/gerona/glq033, PMID 20304770.
D. S. Williams, A. Cash, L. Hamadani, T. Diemer: Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. In: Aging Cell. Band8, Nr.6, 2009, S.765–768, doi:10.1111/j.1474-9726.2009.00527.x, PMID 19793063.
J. M. Haslam, H. A. Krebs: The permeabiliity of mitochondria to oxaloacetate and malate. In: Biochem J. Band107, Nr.5, 1968, S.659–667, doi:10.1042/bj1070659, PMID 16742587.
R. K. Minor, D. L. Smith, A. M. Sossong, S. Kaushik, S. Poosala, E. L. Spangler, G. S. Roth, M. Lane, D. B. Allison, R. de Cabo, D. K. Ingram, J. A. Mattison: Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. In: Toxicol Appl Pharmacol. Band243, Nr.3, 15. März 2010, S.332–339, doi:10.1016/j.taap.2009.11.025, PMID 20026095, PMC 2830378 (freier Volltext).
T. J. Schulz, K. Zarse, A. Voigt, N. Urban, M. Birringer, M. Ristow: Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. In: Cell Metab. Band6, Nr.4, 2007, S.280–293, doi:10.1016/j.cmet.2007.08.011, PMID 17908557.
M. N. Stanfel, L. S. Shamieh, M. Kaeberlein, B. K. Kennedy: The TOR pathway comes of age. In: Biochim Biophys Acta. Band1790, Nr.10, Oktober 2009, S.1067–1074, doi:10.1016/j.bbagen.2009.06.007, PMID 19539012, PMC 3981532 (freier Volltext).
R. A. Miller, D. E. Harrison, C. M. Astle, E. Fernandez, K. Flurkey, M. Han, M. A. Javors, X. Li, N. L. Nadon, J. F. Nelson, S. Pletcher, A. B. Salmon, Z. D. Sharp, S. Van Roekel, L. Winkleman, R. Strong: Rapamycin-Mediated Lifespan Increase in Mice is Dose and Sex-Dependent and Appears Metabolically Distinct from Dietary Restriction. In: Aging Cell. Band13, Nr.3, Juni 2014, S.468–477, doi:10.1111/acel.12194, PMID 24341993, PMC 4032600 (freier Volltext).
Z. Yu, R. Wang, W. C. Fok, A. Coles, A. B. Salmon, V. I. Pérez: Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver. In: J Gerontol A Biol Sci Med Sci. Band70, Nr.4, April 2014, S.410–420, doi:10.1093/gerona/glu053, PMID 24755936.
W. C. Fok, A. Bokov, J. Gelfond, Z. Yu, Y. Zhang, M. Doderer, Y. Chen, M. Javors, W. H. Wood, Y. Zhang, K. G. Becker, A. Richardson, V. I. Pérez: Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver. In: Aging Cell. Band13, Nr.2, April 2014, S.311–319, doi:10.1111/acel.12175, PMID 24304444.