Pasternak GW, Pan YX: Mu opioids and their receptors: evolution of a concept. In: Pharmacol Rev. 65. Jahrgang, Nr.4, 2013, S.1257–317, doi:10.1124/pr.112.007138, PMID 24076545, PMC 3799236 (freier Volltext).
Dietis N, Rowbotham DJ, Lambert DG: Opioid receptor subtypes: fact or artifact? In: Br J Anaesth. 107. Jahrgang, Nr.1, Juli 2011, S.8–18, doi:10.1093/bja/aer115, PMID 21613279.
Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR: Identification of two related pentapeptides from the brain with potent opiate agonist activity. In: Nature. 258. Jahrgang, Nr.5536, 1975, S.577–80, doi:10.1038/258577a0, PMID 1207728.
Fricker LD, Margolis EB, Gomes I, Devi LA: Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. In: Mol Pharmacol. 98. Jahrgang, Nr.2, 2020, S.96–108, doi:10.1124/mol.120.119388, PMID 32487735, PMC 7330675 (freier Volltext).
Evans CJ, Keith DE, Morrison H, Magendzo K, Edwards RH: Cloning of a delta opioid receptor by functional expression. In: Science. 258. Jahrgang, Nr.5090, 1992, S.1952–5, doi:10.1126/science.1335167, PMID 1335167.
Meng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ, Akil H: Cloning and pharmacological characterization of a rat kappa opioid receptor. In: Proc Natl Acad Sci U S A. 90. Jahrgang, Nr.21, 1993, S.9954–8, doi:10.1073/pnas.90.21.9954, PMID 8234341, PMC 47691 (freier Volltext).
Mollereau C, Parmentier M, Mailleux P, Butour JL, Moisand C, Chalon P, Caput D, Vassart G, Meunier JC: ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. In: FEBS Lett. 341. Jahrgang, Nr.1, 1994, S.33–8, doi:10.1016/0014-5793(94)80235-1, PMID 8137918.
Befort K, Mattéi MG, Roeckel N, Kieffer B: Chromosomal localization of the delta opioid receptor gene to human 1p34.3-p36.1 and mouse 4D bands by in situ hybridization. In: Genomics. 20. Jahrgang, Nr.1, 1994, S.143–5, doi:10.1006/geno.1994.1146, PMID 8020949.
Wang JB, Johnson PS, Persico AM, Hawkins AL, Griffin CA, Uhl GR: Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. In: FEBS Lett. 338. Jahrgang, Nr.2, 1994, S.217–22, doi:10.1016/0014-5793(94)80368-4, PMID 7905839.
Yasuda K, Espinosa R, Takeda J, Le Beau MM, Bell GI: Localization of the kappa opioid receptor gene to human chromosome band 8q11.2. In: Genomics. 19. Jahrgang, Nr.3, 1994, S.596–7, doi:10.1006/geno.1994.1117, PMID 8188308.
Bare LA, Mansson E, Yang D: Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain. In: FEBS Lett. 354. Jahrgang, Nr.2, 1994, S.213–6, doi:10.1016/0014-5793(94)01129-x, PMID 7957926.
Beispiel: O’Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK: A µ-opioid receptor modulator that works cooperatively with naloxone. In: Nature. 631. Jahrgang, Nr.8021, 2024, S.686–693, doi:10.1038/s41586-024-07587-7, PMID 38961287.
Beispiel: Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I: Structural and dynamic insights into the activation of the μ-opioid receptor by an allosteric modulator. In: Nat Commun. 15. Jahrgang, Nr.1, 2024, S.3544, doi:10.1038/s41467-024-47792-6, PMID 38740791, PMC 11091225 (freier Volltext).
Piltonen M, Krokhotin A, Parisien M, Bérubé P, Djambazian H, Sladek R, Dokholyan NV, Shabalina SA, Diatchenko L: Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants. In: Cell Mol Neurobiol. 41. Jahrgang, Nr.5, 2021, S.1039–1055, doi:10.1007/s10571-020-00971-7, PMID 33010019, PMC 8159799 (freier Volltext).
Piltonen M, Parisien M, Grégoire S, Chabot-Doré AJ, Jafarnejad SM, Bérubé P, Djambazian H, Sladek R, Geneau G, Willett P, Stone LS, Shabalina SA, Diatchenko L: Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms. In: Mol Neurobiol. 56. Jahrgang, Nr.4, 2019, S.2855–2869, doi:10.1007/s12035-018-1253-z, PMID 30066306.
Ugur M, Derouiche L, Massotte D: Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo. In: Front Pharmacol. 9. Jahrgang, 2018, S.1240, doi:10.3389/fphar.2018.01240, PMID 30483121, PMC 6244869 (freier Volltext).
Zhang L, Zhang JT, Hang L, Liu T: Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective. In: Front Pharmacol. 11. Jahrgang, 2020, S.1078, doi:10.3389/fphar.2020.01078, PMID 32760281, PMC 7373791 (freier Volltext).
Gaborit M, Massotte D: Therapeutic potential of opioid receptor heteromers in chronic pain and associated comorbidities. In: Br J Pharmacol. 180. Jahrgang, Nr.7, 2023, S.994–1013, doi:10.1111/bph.15772, PMID 34883528.
Cechova K, Lan C, Macik M, Barthes NPF, Jung M, Ulbrich MH: Kappa but not delta or mu opioid receptors form homodimers at low membrane densities. In: Cell Mol Life Sci. 78. Jahrgang, Nr.23, 2021, S.7557–7568, doi:10.1007/s00018-021-03963-y, PMID 34657173, PMC 8629795 (freier Volltext).
Li-Wei C, Can G, De-He Z, Qiang W, Xue-Jun X, Jie C, Zhi-Qiang C: Homodimerization of human mu-opioid receptor overexpressed in Sf9 insect cells. In: Protein Pept Lett. 9. Jahrgang, Nr.2, 2002, S.145–52, doi:10.2174/0929866023408850, PMID 12141912.
Fujita W, Gomes I, Devi LA: Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities. In: Br J Pharmacol. 172. Jahrgang, Nr.2, 2015, S.375–87, doi:10.1111/bph.12663, PMID 24571499, PMC 4292954 (freier Volltext).
Pasternak GW, Pan YX: Mu opioids and their receptors: evolution of a concept. In: Pharmacol Rev. 65. Jahrgang, Nr.4, 2013, S.1257–317, doi:10.1124/pr.112.007138, PMID 24076545, PMC 3799236 (freier Volltext).
Dietis N, Rowbotham DJ, Lambert DG: Opioid receptor subtypes: fact or artifact? In: Br J Anaesth. 107. Jahrgang, Nr.1, Juli 2011, S.8–18, doi:10.1093/bja/aer115, PMID 21613279.
Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR: Identification of two related pentapeptides from the brain with potent opiate agonist activity. In: Nature. 258. Jahrgang, Nr.5536, 1975, S.577–80, doi:10.1038/258577a0, PMID 1207728.
Fricker LD, Margolis EB, Gomes I, Devi LA: Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. In: Mol Pharmacol. 98. Jahrgang, Nr.2, 2020, S.96–108, doi:10.1124/mol.120.119388, PMID 32487735, PMC 7330675 (freier Volltext).
Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE: The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. In: J Pharmacol Exp Ther. 197. Jahrgang, Nr.3, 1976, S.517–32, PMID 945347.
Evans CJ, Keith DE, Morrison H, Magendzo K, Edwards RH: Cloning of a delta opioid receptor by functional expression. In: Science. 258. Jahrgang, Nr.5090, 1992, S.1952–5, doi:10.1126/science.1335167, PMID 1335167.
Meng F, Xie GX, Thompson RC, Mansour A, Goldstein A, Watson SJ, Akil H: Cloning and pharmacological characterization of a rat kappa opioid receptor. In: Proc Natl Acad Sci U S A. 90. Jahrgang, Nr.21, 1993, S.9954–8, doi:10.1073/pnas.90.21.9954, PMID 8234341, PMC 47691 (freier Volltext).
Chen Y, Mestek A, Liu J, Hurley JA, Yu L: Molecular cloning and functional expression of a mu-opioid receptor from rat brain. In: Mol Pharmacol. 44. Jahrgang, Nr.1, 1993, S.8–12, PMID 8393525.
Mollereau C, Parmentier M, Mailleux P, Butour JL, Moisand C, Chalon P, Caput D, Vassart G, Meunier JC: ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. In: FEBS Lett. 341. Jahrgang, Nr.1, 1994, S.33–8, doi:10.1016/0014-5793(94)80235-1, PMID 8137918.
Befort K, Mattéi MG, Roeckel N, Kieffer B: Chromosomal localization of the delta opioid receptor gene to human 1p34.3-p36.1 and mouse 4D bands by in situ hybridization. In: Genomics. 20. Jahrgang, Nr.1, 1994, S.143–5, doi:10.1006/geno.1994.1146, PMID 8020949.
Wang JB, Johnson PS, Persico AM, Hawkins AL, Griffin CA, Uhl GR: Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment. In: FEBS Lett. 338. Jahrgang, Nr.2, 1994, S.217–22, doi:10.1016/0014-5793(94)80368-4, PMID 7905839.
Yasuda K, Espinosa R, Takeda J, Le Beau MM, Bell GI: Localization of the kappa opioid receptor gene to human chromosome band 8q11.2. In: Genomics. 19. Jahrgang, Nr.3, 1994, S.596–7, doi:10.1006/geno.1994.1117, PMID 8188308.
Bare LA, Mansson E, Yang D: Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain. In: FEBS Lett. 354. Jahrgang, Nr.2, 1994, S.213–6, doi:10.1016/0014-5793(94)01129-x, PMID 7957926.
Beispiel: O’Brien ES, Rangari VA, El Daibani A, Eans SO, Hammond HR, White E, Wang H, Shiimura Y, Krishna Kumar K, Jiang Q, Appourchaux K, Huang W, Zhang C, Kennedy BJ, Mathiesen JM, Che T, McLaughlin JP, Majumdar S, Kobilka BK: A µ-opioid receptor modulator that works cooperatively with naloxone. In: Nature. 631. Jahrgang, Nr.8021, 2024, S.686–693, doi:10.1038/s41586-024-07587-7, PMID 38961287.
Beispiel: Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I: Structural and dynamic insights into the activation of the μ-opioid receptor by an allosteric modulator. In: Nat Commun. 15. Jahrgang, Nr.1, 2024, S.3544, doi:10.1038/s41467-024-47792-6, PMID 38740791, PMC 11091225 (freier Volltext).
Piltonen M, Krokhotin A, Parisien M, Bérubé P, Djambazian H, Sladek R, Dokholyan NV, Shabalina SA, Diatchenko L: Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants. In: Cell Mol Neurobiol. 41. Jahrgang, Nr.5, 2021, S.1039–1055, doi:10.1007/s10571-020-00971-7, PMID 33010019, PMC 8159799 (freier Volltext).
Piltonen M, Parisien M, Grégoire S, Chabot-Doré AJ, Jafarnejad SM, Bérubé P, Djambazian H, Sladek R, Geneau G, Willett P, Stone LS, Shabalina SA, Diatchenko L: Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms. In: Mol Neurobiol. 56. Jahrgang, Nr.4, 2019, S.2855–2869, doi:10.1007/s12035-018-1253-z, PMID 30066306.
Ugur M, Derouiche L, Massotte D: Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo. In: Front Pharmacol. 9. Jahrgang, 2018, S.1240, doi:10.3389/fphar.2018.01240, PMID 30483121, PMC 6244869 (freier Volltext).
Zhang L, Zhang JT, Hang L, Liu T: Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective. In: Front Pharmacol. 11. Jahrgang, 2020, S.1078, doi:10.3389/fphar.2020.01078, PMID 32760281, PMC 7373791 (freier Volltext).
Gaborit M, Massotte D: Therapeutic potential of opioid receptor heteromers in chronic pain and associated comorbidities. In: Br J Pharmacol. 180. Jahrgang, Nr.7, 2023, S.994–1013, doi:10.1111/bph.15772, PMID 34883528.
Cechova K, Lan C, Macik M, Barthes NPF, Jung M, Ulbrich MH: Kappa but not delta or mu opioid receptors form homodimers at low membrane densities. In: Cell Mol Life Sci. 78. Jahrgang, Nr.23, 2021, S.7557–7568, doi:10.1007/s00018-021-03963-y, PMID 34657173, PMC 8629795 (freier Volltext).
Li-Wei C, Can G, De-He Z, Qiang W, Xue-Jun X, Jie C, Zhi-Qiang C: Homodimerization of human mu-opioid receptor overexpressed in Sf9 insect cells. In: Protein Pept Lett. 9. Jahrgang, Nr.2, 2002, S.145–52, doi:10.2174/0929866023408850, PMID 12141912.
Fujita W, Gomes I, Devi LA: Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities. In: Br J Pharmacol. 172. Jahrgang, Nr.2, 2015, S.375–87, doi:10.1111/bph.12663, PMID 24571499, PMC 4292954 (freier Volltext).