B. Knudsen, J. Lucas, P. Nelson: Serine Proteases (Type II) Spanning the Plasma Membrane. In: M. Schwab (Hrsg.): Encyclopedia of Cancer. Springer, Berlin, Heidelberg, 2011. doi:10.1007/978-3-642-16483-5_5257
Jean Kaoru Millet, Gary R. Whittaker: Host cell proteases: critical determinants of coronavirus tropism and pathogenesis. In: Virus Res. 16. April 2015, doi:10.1016/j.virusres.2014.11.021 (englisch).
A. Shulla, T. Heald-Sargent, G. Subramanya, J. Zhao, S. Perlman, T. Gallagher: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. In: Journal of Virology. Band 85, Nummer 2, Januar 2011, S. 873–882, doi:10.1128/JVI.02062-10. PMID 21068237, PMC 3020023 (freier Volltext).
K. Shirato, K. Kanou, M. Kawase, S. Matsuyama: Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. In: J Virol. Dez 2016, doi:10.1128/JVI.01387-16. PMID 27733646.
A. Zumla, J. F. Chan, E. I. Azhar, D. S. Hui, K. Y. Yuen: Coronaviruses - drug discovery and therapeutic options. In: Nature reviews. Drug discovery. Band 15, Nummer 5, 2016, S. 327–347, doi:10.1038/nrd.2015.37. PMID 26868298 (Review).
J. K. Sai, M. Suyama, Y. Kubokawa, Y. Matsumura, K. Inami, S. Watanabe: Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic disease. In: Journal of gastroenterology. Band 45, Nummer 3, März 2010, S. 335–341, doi:10.1007/s00535-009-0148-1. PMID 19876587.
R. Talukdar, R. K. Tandon: Pancreatic stellate cells: new target in the treatment of chronic pancreatitis. In: Journal of gastroenterology and hepatology. Band 23, Nummer 1, Januar 2008, S. 34–41, doi:10.1111/j.1440-1746.2007.05206.x. PMID 17995943 (Review).
J. F. W. Chan, S. K. P. Lau, K. K. W. To, V. C. C. Cheng, P. C. Y. Woo, K.-Y. Yuen: Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. In: Clin Microbiol Rev. 15. März 2015, doi:10.1128/CMR.00102-14 (englisch).
A. V. Ovcharenko, O. P. Zhirnov: Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice. In: Antiviral research. Band 23, Nummer 2, Februar 1994, S. 107–118, doi:10.1016/0166-3542(94)90038-8. PMID 7511880.
M. Yamamoto, S. Matsuyama, X. Li, M. Takeda, Y. Kawaguchi, J. I. Inoue, Z. Matsuda: Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. In: Antimicrobial agents and chemotherapy. Band 60, Nummer 11, 11 2016, S. 6532–6539, doi:10.1128/AAC.01043-16. PMID 27550352, PMC 5075056 (freier Volltext).
J. M. Lucas, C. Heinlein, T. Kim, S. A. Hernandez, M. S. Malik, L. D. True, C. Morrissey, E. Corey, B. Montgomery, E. Mostaghel, N. Clegg, I. Coleman, C. M. Brown, E. L. Schneider, C. Craik, J. A. Simon, A. Bedalov, P. S. Nelson: The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. In: Cancer discovery. Band 4, Nummer 11, November 2014, S. 1310–1325, doi:10.1158/2159-8290.CD-13-1010. PMID 25122198, PMC 4409786 (freier Volltext).
E. Böttcher, C. Freuer, T. Steinmetzer, H. D. Klenk, W. Garten: MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. In: Vaccine. Band 27, Nummer 45, Oktober 2009, S. 6324–6329, doi:10.1016/j.vaccine.2009.03.029. PMID 19840668.
G. Simmons, S. Bertram, I. Glowacka, I. Steffen, C. Chaipan, J. Agudelo, K. Lu, A. J. Rennekamp, H. Hofmann, P. Bates, S. Pöhlmann: Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion. In: Virology. Band 413, Nummer 2, Mai 2011, S. 265–274, doi:10.1016/j.virol.2011.02.020. PMID 21435673, PMC 3086175 (freier Volltext).
D. Meyer, F. Sielaff, M. Hammami, E. Böttcher-Friebertshäuser, W. Garten, T. Steinmetzer: Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. In: The Biochemical journal. Band 452, Nummer 2, Juni 2013, S. 331–343, doi:10.1042/BJ20130101. PMID 23527573.
E. Böttcher-Friebertshäuser, C. Freuer, F. Sielaff, S. Schmidt, M. Eickmann, J. Uhlendorff, T. Steinmetzer, H. D. Klenk, W. Garten: Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. In: Journal of Virology. Band 84, Nummer 11, Juni 2010, S. 5605–5614, doi:10.1128/JVI.00140-10. PMID 20237084, PMC 2876594 (freier Volltext).
N. Iwata-Yoshikawa, T. Okamura, Y. Shimizu, H. Hasegawa, M. Takeda, N. Nagata: TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. In: J Virol. 5. März 2019, doi:10.1128/JVI.01815-18 (englisch).
Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S. Schiergens, Georg Herrler, Nai-Huei Wu, Andreas Nitsche, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. In: Cell. 2020. doi:10.1016/j.cell.2020.02.052
Bryce A. Schuler, A. Christian Habermann, Erin J. Plosa, Chase J. Taylor, Christopher Jetter, Nicholas M. Negretti, Meghan E. Kapp, John T. Benjamin, Peter Gulleman, David S. Nichols, Lior Z. Braunstein, Alice Hackett, Michael Koval, Susan H. Guttentag, Timothy S. Blackwell, Steven A. Webber, Nicholas E. Banovich, Jonathan A. Kropski, Jennifer M. S. Sucre: Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium. In: JCI. 2020. doi:10.1172/JCI140766
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A. Shulla, T. Heald-Sargent, G. Subramanya, J. Zhao, S. Perlman, T. Gallagher: A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry. In: Journal of Virology. Band 85, Nummer 2, Januar 2011, S. 873–882, doi:10.1128/JVI.02062-10. PMID 21068237, PMC 3020023 (freier Volltext).
K. Shirato, K. Kanou, M. Kawase, S. Matsuyama: Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. In: J Virol. Dez 2016, doi:10.1128/JVI.01387-16. PMID 27733646.
A. Zumla, J. F. Chan, E. I. Azhar, D. S. Hui, K. Y. Yuen: Coronaviruses - drug discovery and therapeutic options. In: Nature reviews. Drug discovery. Band 15, Nummer 5, 2016, S. 327–347, doi:10.1038/nrd.2015.37. PMID 26868298 (Review).
J. K. Sai, M. Suyama, Y. Kubokawa, Y. Matsumura, K. Inami, S. Watanabe: Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic disease. In: Journal of gastroenterology. Band 45, Nummer 3, März 2010, S. 335–341, doi:10.1007/s00535-009-0148-1. PMID 19876587.
R. Talukdar, R. K. Tandon: Pancreatic stellate cells: new target in the treatment of chronic pancreatitis. In: Journal of gastroenterology and hepatology. Band 23, Nummer 1, Januar 2008, S. 34–41, doi:10.1111/j.1440-1746.2007.05206.x. PMID 17995943 (Review).
A. V. Ovcharenko, O. P. Zhirnov: Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice. In: Antiviral research. Band 23, Nummer 2, Februar 1994, S. 107–118, doi:10.1016/0166-3542(94)90038-8. PMID 7511880.
M. Yamamoto, S. Matsuyama, X. Li, M. Takeda, Y. Kawaguchi, J. I. Inoue, Z. Matsuda: Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay. In: Antimicrobial agents and chemotherapy. Band 60, Nummer 11, 11 2016, S. 6532–6539, doi:10.1128/AAC.01043-16. PMID 27550352, PMC 5075056 (freier Volltext).
J. M. Lucas, C. Heinlein, T. Kim, S. A. Hernandez, M. S. Malik, L. D. True, C. Morrissey, E. Corey, B. Montgomery, E. Mostaghel, N. Clegg, I. Coleman, C. M. Brown, E. L. Schneider, C. Craik, J. A. Simon, A. Bedalov, P. S. Nelson: The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. In: Cancer discovery. Band 4, Nummer 11, November 2014, S. 1310–1325, doi:10.1158/2159-8290.CD-13-1010. PMID 25122198, PMC 4409786 (freier Volltext).
E. Böttcher, C. Freuer, T. Steinmetzer, H. D. Klenk, W. Garten: MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition. In: Vaccine. Band 27, Nummer 45, Oktober 2009, S. 6324–6329, doi:10.1016/j.vaccine.2009.03.029. PMID 19840668.
G. Simmons, S. Bertram, I. Glowacka, I. Steffen, C. Chaipan, J. Agudelo, K. Lu, A. J. Rennekamp, H. Hofmann, P. Bates, S. Pöhlmann: Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion. In: Virology. Band 413, Nummer 2, Mai 2011, S. 265–274, doi:10.1016/j.virol.2011.02.020. PMID 21435673, PMC 3086175 (freier Volltext).
D. Meyer, F. Sielaff, M. Hammami, E. Böttcher-Friebertshäuser, W. Garten, T. Steinmetzer: Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. In: The Biochemical journal. Band 452, Nummer 2, Juni 2013, S. 331–343, doi:10.1042/BJ20130101. PMID 23527573.
E. Böttcher-Friebertshäuser, C. Freuer, F. Sielaff, S. Schmidt, M. Eickmann, J. Uhlendorff, T. Steinmetzer, H. D. Klenk, W. Garten: Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. In: Journal of Virology. Band 84, Nummer 11, Juni 2010, S. 5605–5614, doi:10.1128/JVI.00140-10. PMID 20237084, PMC 2876594 (freier Volltext).
