Αναστολέας ενζύμου (Greek Wikipedia)

Analysis of information sources in references of the Wikipedia article "Αναστολέας ενζύμου" in Greek language version.

refsWebsite

Global rank Greek rank

111nih.gov

4^th place

90doi.org

2^nd place

3^rd place

19web.archive.org

1^st place

12archive.org

6^th place

5^th place

11books.google.com

3^rd place

6^th place

4harvard.edu

18^th place

57^th place

1rcsb.org

8,838^th place

low place

1dtic.mil

833^rd place

1,293^rd place

1wiley-vch.de

low place

1clinicalkey.com

low place

1zenodo.org

621^st place

1,469^th place

1qub.ac.uk

8,565^th place

3,194^th place

1scientificamerican.com

896^th place

1,055^th place

1worldcat.org

5^th place

8^th place

1mhmedical.com

6,846^th place

low place

archive.org

Palmer T, Bonner PL (2007). «Enzyme inhibition.». Enzymes: Biochemistry, Biotechnology, Clinical Chemistry (2nd έκδοση). Woodhead Publishing. σελίδες 126–152 (135). doi:10.1533/9780857099921.2.126. ISBN 978-1-904275-27-5.
Voet D, Voet JG, Pratt CW (2016). «Chapter 12: Enzyme Kinetics, Inhibition, and Control». Fundamentals of Biochemistry: Life at the Molecular Level (Fifth έκδοση). Hoboken, NJ: Wiley. σελίδες 361–401. ISBN 978-1-118-91840-1.
«Amylase/creatinine clearance fraction in patients on chronic hemodialysis». Annals of Internal Medicine 86 (1): 65–66. January 1977. doi:10.7326/0003-4819-86-1-65. PMID 319722. https://archive.org/details/sim_annals-of-internal-medicine_1977-01_86_1/page/65.
Price N, Hames B, Rickwood D (1996). Proteins LabFax. BIOS Scientific Publishers. ISBN 978-0-12-564710-6.
«Application of mass spectrometry for target identification and characterization». Medicinal Research Reviews 19 (4): 307–319. July 1999. doi:10.1002/(SICI)1098-1128(199907)19:4<307::AID-MED4>3.0.CO;2-2. PMID 10398927. https://archive.org/details/sim_medicinal-research-reviews_1999-07_19_4/page/307.
Brenner GM (2000). Pharmacology (1st έκδοση). Philadelphia, PA: W.B. Saunders. ISBN 978-0-7216-7757-6.
«Suicide substrates, mechanism-based enzyme inactivators: recent developments». Annual Review of Biochemistry 53: 493–535. 1984. doi:10.1146/annurev.bi.53.070184.002425. PMID 6433782. https://archive.org/details/sim_annual-review-of-biochemistry_1984_53_annual/page/493.
Price NC, Stevens L (1999). Fundamentals of enzymology : the cell and molecular biology of catalytic proteins (3rd έκδοση). Oxford University Press. ISBN 978-0-19-850229-6.
«Antimuscarinic intoxication resulting from the ingestion of moonflower seeds». The Annals of Pharmacotherapy 39 (1): 173–176. January 2005. doi:10.1345/aph.1D536. PMID 15572604. https://archive.org/details/sim_annals-of-pharmacotherapy_2005-01_39_1/page/173.
«Toxins of Amanita phalloides». Toxicon 36 (1): 13–24. January 1998. doi:10.1016/S0041-0101(97)00074-3. PMID 9604278. https://archive.org/details/sim_toxicon_1998-01_36_1/page/13.
Savage GP, Morrison SC (2003). «Trypsin inhibitors.». Στο: Caballero B, επιμ. Encyclopedia of Food Sciences and Nutrition (Second έκδοση). Academic Press. σελίδες 5878–5884. doi:10.1016/B0-12-227055-X/00934-2. ISBN 978-0-12-227055-0.
«Overview of herbicide mechanisms of action». Environmental Health Perspectives 87: 263–271. July 1990. doi:10.2307/3431034. PMID 1980104. PMC 1567841. https://archive.org/details/sim_environmental-health-perspectives_1990-07_87/page/263.

books.google.com

Plaxton WC (2004). «Principles of Metabolic Control». Στο: Storey KB, επιμ. Functional Metabolism: Regulation and Adaptation. Hoboken, N.J.: John Wiley & Sons. σελίδες 1–24 (12). ISBN 978-0-471-67557-0. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
Rydzewski RM (2010). «Chapter 7.2.1: Competition and Allostery». Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research (1st έκδοση). Amsterdam: Elsevier. σελίδες 281–285. ISBN 978-0-08-091488-6. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 20 Ιουλίου 2022.
Patrick GL (2013). «Chapter 7: Enzymes as Drug Targets». An Introduction to Medicinal Chemistry (Fifth έκδοση). Oxford, UK: Oxford University Press. σελ. 90. ISBN 978-0-19-969739-7. Αρχειοθετήθηκε από το πρωτότυπο στις 20 Ιουλίου 2022. Ανακτήθηκε στις 20 Ιουλίου 2022.
Kuriyan J, Konforti B, Wemmer D (2012). «Molecular Recognition: The Thermodynamics of Binding». The Molecules of Life : Physical and Chemical Principles (First έκδοση). Boca Raton, FL: Garland Science. σελίδες 531–580. ISBN 978-1-135-08892-7. Αρχειοθετήθηκε από το πρωτότυπο στις 7 Ιουνίου 2022. Ανακτήθηκε στις 7 Ιουνίου 2022.
Patrick GL (2017). «Enzymes as Drug Targets». An Introduction to Medicinal Chemistry (Sixth έκδοση). Oxford, United Kingdom: Oxford University Press. σελ. 95. ISBN 978-0-19-874969-1. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 3 Ιουνίου 2022.
Purich DL (2010). «Irreversible Enzyme Inhibition by Affinity Labelling Agents». Enzyme Kinetics: Catalysis and Control: A Reference of Theory and Best-Practice Methods. San Diego, Calif.: Elsevier Academic. σελ. 542. ISBN 978-0-12-380925-4. Αρχειοθετήθηκε από το πρωτότυπο στις 20 Ιουλίου 2022. Ανακτήθηκε στις 20 Ιουλίου 2022.
Stenersen J (2004). «Chapter 5: Specific Enzyme Inhibitors». Chemical Pesticides Mode of Action and Toxicology. Boca Raton: CRC Press. σελίδες 73–114. ISBN 978-0-203-64683-0. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
Orencio-Trejo M, Utrilla J, Fernández-Sandoval MT, Huerta-Beristain G, Gosset G, Martinez A (2010). «Engineering the Escherichia coli Fermentative Metabolism». Στο: Cordes M, Wittmann C, Krull R, επιμ. Biosystems Engineering II: Linking Cellular Networks and Bioprocesses. Berlin: Springer Science & Business Media. σελίδες 77–78. ISBN 978-3-642-13865-2.
Finkel R, Cubeddu LX, Clark MA (2009). «Chapter 41: Antiinfammatory Drugs». Pharmacology (4th έκδοση). Philadelphia: Lippincott Williams & Wilkins. σελίδες 499–518 (502). ISBN 978-0-7817-7155-9. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
Gupta RC (2006). «Classification and Uses of Organophosphates and Carbamates». Στο: Gupta RC, επιμ. Toxicology of Organophosphate and Carbamate Compounds. Amsterdam: Elsevier Academic Press. σελίδες 5–24. ISBN 978-0-08-054310-9. Αρχειοθετήθηκε από το πρωτότυπο στις 21 Ιουλίου 2022. Ανακτήθηκε στις 21 Ιουλίου 2022.
Hirai K, Uchida A, Ohno R (2012). «Major Synthetic Routes for Modern Herbicide Classes and Agrochemical Characteristics». Στο: Böger P, Wakabayashi K, Hirai K, επιμ. Herbicide Classes in Development. Springer Science & Business Media. σελίδες 179–195. doi:10.1007/978-3-642-59416-8_10. ISBN 978-3-642-59416-8. Αρχειοθετήθηκε από το πρωτότυπο στις 27 Ιουνίου 2022. Ανακτήθηκε στις 27 Ιουνίου 2022. Chapter 10.2.1: Sulfonylurea acetolactate synthase inhibitors

clinicalkey.com

Page C, Pitchford S (2021). «Venoms, toxins, poisons and herbs». Dale's Pharmacology Condensed E-Book (Third έκδοση). Philadelphia, Pa.: Elsevier Health Sciences. σελίδες 153–155. ISBN 978-0-7020-7819-4. Αρχειοθετήθηκε από το πρωτότυπο στις 25 Απριλίου 2013. Ανακτήθηκε στις 3 Ιουνίου 2022.

doi.org

dx.doi.org

«Control and regulation of pathways via negative feedback». Journal of the Royal Society, Interface 14 (127): 1–13. February 2017. doi:10.1098/rsif.2016.0848. PMID 28202588.
«Drugs from the deep: marine natural products as drug candidates». Drug Discovery Today 8 (12): 536–44. June 2003. doi:10.1016/s1359-6446(03)02713-2. PMID 12821301.
«SERPINs-From Trap to Treatment». Frontiers in Medicine 6: 25. 2019. doi:10.3389/fmed.2019.00025. PMID 30809526.
«Interaction of human placental ribonuclease with placental ribonuclease inhibitor». Biochemistry 30 (8): 2246–2255. February 1991. doi:10.1021/bi00222a030. PMID 1998683.
«Protease propeptide structures, mechanisms of activation, and functions». Critical Reviews in Biochemistry and Molecular Biology 55 (2): 111–165. April 2020. doi:10.1080/10409238.2020.1742090. PMID 32290726.
«Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators». PLOS ONE 14 (3): e0214255. 2019. doi:10.1371/journal.pone.0214255. PMID 30917186. Bibcode: 2019PLoSO..1414255J.
«The Taxonomy of Covalent Inhibitors». Biochemistry 57 (24): 3326–3337. June 2018. doi:10.1021/acs.biochem.8b00315. PMID 29689165.
«The kinetics of enzyme-catalysed reactions with two or more substrates or products. II. Inhibition: nomenclature and theory». Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects 67: 173–187. February 1963. doi:10.1016/0926-6569(63)90226-8. PMID 14021668.
«Enzyme-Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality». SLAS Discovery: Advancing Life Sciences R & D 24 (5): 515–522 (516). June 2019. doi:10.1177/2472555219829898. PMID 30811960. «In some cases, the inhibitor may bind to a distinct site on the enzyme that is in allosteric communication with the substrate binding pocket. In many cases, allosteric, substrate competitive compounds result in conformational changes to the enzyme that change the ability of the enzyme to bind substrate.».
«Limitations of conventional inhibitor classifications». Integrative Biology 3 (12): 1197–1201. December 2011. doi:10.1039/c1ib00053e. PMID 22038120.
«A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase». Biochimica et Biophysica Acta (BBA) - General Subjects 1770 (5): 733–746. May 2007. doi:10.1016/j.bbagen.2007.01.001. PMID 17307293.
«Using linear and non-linear regression to fit biochemical data». Trends in Biochemical Sciences 15 (12): 455–458. December 1990. doi:10.1016/0968-0004(90)90295-M. PMID 2077683.
«A comparison of the parameter estimating procedures for the Michaelis-Menten model». Journal of Theoretical Biology 145 (4): 457–464. August 1990. doi:10.1016/S0022-5193(05)80481-3. PMID 2246896. Bibcode: 1990JThBi.145..457T.
«Amylase/creatinine clearance fraction in patients on chronic hemodialysis». Annals of Internal Medicine 86 (1): 65–66. January 1977. doi:10.7326/0003-4819-86-1-65. PMID 319722. https://archive.org/details/sim_annals-of-internal-medicine_1977-01_86_1/page/65.
«A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant». Journal of Medicinal Chemistry 32 (5): 937–940. May 1989. doi:10.1021/jm00125a002. PMID 2709379.
«Multisubstrate Adduct Inhibitors of Glycinamide Ribonucleotide Transformylase: Synthetic and Enzyme Generated.». Tetrahedron 47 (14–15): 2351–2364. 1991. doi:10.1016/S0040-4020(01)81773-7.
«Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis». Science 279 (5347): 98–102. January 1998. doi:10.1126/science.279.5347.98. PMID 9417034. Bibcode: 1998Sci...279...98R.
«Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124». Proceedings of the National Academy of Sciences of the United States of America 107 (11): 4878–4883. March 2010. doi:10.1073/pnas.0909141107. PMID 20194791. Bibcode: 2010PNAS..107.4878A.
«Multisubstrate adduct inhibitors: drug design and biological tools». Journal of Enzyme Inhibition and Medicinal Chemistry 24 (6): 1291–318. December 2009. doi:10.3109/14756360902843809. PMID 19912064.
«Antiviral drug discovery targeting to viral proteases». Current Pharmaceutical Design 12 (11): 1301–1314. 2006. doi:10.2174/138161206776361110. PMID 16611117.
«Proteases and protease inhibitors in infectious diseases». Medicinal Research Reviews 38 (4): 1295–1331. July 2018. doi:10.1002/med.21475. PMID 29149530.
«Recent developments of peptidomimetic HIV-1 protease inhibitors». Current Medicinal Chemistry 18 (29): 4513–37. 2011. doi:10.2174/092986711797287566. PMID 21864279.
«Enzymatic Transition States and Drug Design». Chemical Reviews 118 (22): 11194–11258. November 2018. doi:10.1021/acs.chemrev.8b00369. PMID 30335982.
«Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor». Current Medicinal Chemistry 7 (6): 663–672. June 2000. doi:10.2174/0929867003374886. PMID 10702632.
«The design, synthesis and application of stereochemical and directional peptide isomers: a critical review». Current Protein & Peptide Science 4 (5): 339–356. October 2003. doi:10.2174/1389203033487054. PMID 14529528.
«Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges». ACS Chemical Biology 10 (1): 175–89. January 2015. doi:10.1021/cb5008376. PMID 25494294.
«Peptide inhibitors of protein kinases-discovery, characterisation and use». Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1754 (1–2): 79–99. December 2005. doi:10.1016/j.bbapap.2005.07.025. PMID 16182621.
«Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology». Journal of Medicinal Chemistry 62 (12): 5673–5724. June 2019. doi:10.1021/acs.jmedchem.8b01153. PMID 30565923.
«Approaches for improved identification of mechanisms of enzyme inactivation.». Progress in Biotechnology (Elsevier) 15: 77–82. January 1998. doi:10.1016/S0921-0423(98)80013-0. ISBN 978-0-444-82970-2. «Enzyme inactivation is generally explained as a chemical process involving several phenomena like aggregation, dissociation into subunits, or denaturation (conformational changes), which occur simultaneously during the inactivation of a specific enzyme.».
«Profiling the specific reactivity of the proteome with non-directed activity-based probes». Chemistry & Biology 8 (1): 81–95. January 2001. doi:10.1016/S1074-5521(00)90060-7. PMID 11182321.
«Comparison of methods for analyzing kinetic data from mechanism-based enzyme inactivation: application to nitric oxide synthase». AAPS PharmSci 2 (1): 68–77. 2000. doi:10.1208/ps020108. PMID 11741224.
«Application of mass spectrometry for target identification and characterization». Medicinal Research Reviews 19 (4): 307–319. July 1999. doi:10.1002/(SICI)1098-1128(199907)19:4<307::AID-MED4>3.0.CO;2-2. PMID 10398927. https://archive.org/details/sim_medicinal-research-reviews_1999-07_19_4/page/307.
«Development of a matrix-assisted laser desorption/ionization-mass spectrometry screening test to evidence reversible and irreversible inhibitors of CDC25 phosphatases». Analytical Biochemistry 430 (1): 83–91. November 2012. doi:10.1016/j.ab.2012.08.006. PMID 22902804.
«Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites». The Journal of Biological Chemistry 267 (1): 150–158. January 1992. doi:10.1016/S0021-9258(18)48472-4. PMID 1730582.
«Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogs». Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 869 (3): 275–285. February 1986. doi:10.1016/0167-4838(86)90067-1. PMID 3511964.
«Reaction of formaldehyde and of methanol with xanthine oxidase». European Journal of Biochemistry 18 (1): 65–72. January 1971. doi:10.1111/j.1432-1033.1971.tb01215.x. PMID 4322209.
«Herpes simplex virus type 1 and human DNA polymerase interactions with 2'-deoxyguanosine 5'-triphosphate analogs. Kinetics of incorporation into DNA and induction of inhibition». The Journal of Biological Chemistry 264 (32): 19039–19044. November 1989. doi:10.1016/S0021-9258(19)47263-3. PMID 2553730.
PDB: 1GXF; «Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design». The Journal of Biological Chemistry 279 (28): 29493–500. July 2004. doi:10.1074/jbc.M403187200. PMID 15102853.
«Suicide substrates, mechanism-based enzyme inactivators: recent developments». Annual Review of Biochemistry 53: 493–535. 1984. doi:10.1146/annurev.bi.53.070184.002425. PMID 6433782. https://archive.org/details/sim_annual-review-of-biochemistry_1984_53_annual/page/493.
«Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design». The Journal of Biological Chemistry 279 (28): 29493–29500. July 2004. doi:10.1074/jbc.M403187200. PMID 15102853.
«Enzyme inhibitors as chemical tools to study enzyme catalysis: rational design, synthesis, and applications». Chemical Record (New York, N.Y.) 5 (4): 209–28. 2005. doi:10.1002/tcr.20045. PMID 16041744.
«Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes». BioFactors 10 (1): 1–14. 1999. doi:10.1002/biof.5520100101. PMID 10475585.
«Substrate variants versus transition state analogues as noncovalent reversible enzyme inhibitors». Bioorganic & Medicinal Chemistry 12 (15): 4081–4088. August 2004. doi:10.1016/j.bmc.2004.05.041. PMID 15246086. https://zenodo.org/record/998967. Ανακτήθηκε στις 14 April 2022.
«Barnase and barstar: two small proteins to fold and fit together». Trends in Biochemical Sciences 14 (11): 450–454. November 1989. doi:10.1016/0968-0004(89)90104-7. PMID 2696173.
«Biodiversity as a source of anticancer drugs». Current Drug Targets 7 (3): 265–277. March 2006. doi:10.2174/138945006776054942. PMID 16515527.
«Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action». Current Cancer Drug Targets 3 (3): 193–203. June 2003. doi:10.2174/1568009033481967. PMID 12769688.
«Natural Product Inhibitors of Acetylcholinesterase». Current Organic Chemistry 10 (8): 825–847. 2006. doi:10.2174/138527206776894410.
«A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia». Dementia and Geriatric Cognitive Disorders 45 (3–4): 131–151. 2018. doi:10.1159/000486546. PMID 29734182.
«Antimuscarinic intoxication resulting from the ingestion of moonflower seeds». The Annals of Pharmacotherapy 39 (1): 173–176. January 2005. doi:10.1345/aph.1D536. PMID 15572604. https://archive.org/details/sim_annals-of-pharmacotherapy_2005-01_39_1/page/173.
«Toxins of Amanita phalloides». Toxicon 36 (1): 13–24. January 1998. doi:10.1016/S0041-0101(97)00074-3. PMID 9604278. https://archive.org/details/sim_toxicon_1998-01_36_1/page/13.
«Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins». Current Medicinal Chemistry 9 (22): 1981–1989. November 2002. doi:10.2174/0929867023368827. PMID 12369866.
«Ricin: An Ancient Story for a Timeless Plant Toxin». Toxins 11 (6): 324. June 2019. doi:10.3390/toxins11060324. PMID 31174319.
«Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin». Toxins 11 (6): 350. June 2019. doi:10.3390/toxins11060350. PMID 31216687.
«Cytotoxic ribosome-inactivating lectins from plants». Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1701 (1–2): 1–14. September 2004. doi:10.1016/j.bbapap.2004.06.004. PMID 15450171.
«A comprehensive map of molecular drug targets». Nature Reviews. Drug Discovery 16 (1): 19–34 (Figure 1C). January 2017. doi:10.1038/nrd.2016.230. PMID 27910877. «Figure 1C: Clinical success of privileged protein family classes (% approved drugs targeting each target class): Reductase 7.62, Kinase 5.94, Protease 3.35, Hydrolase 2.76, NPTase 2.09, Transferase 1.92, Lyase 1.59, Isomerase 1.51, Phosphodiesterase 1.50, Cytochrome p450 0.84, Epigenetic eraser 0.33, Total enzyme targets of approved drugs = 29.45%».
«A comprehensive review of protein kinase inhibitors for cancer therapy». Expert Review of Anticancer Therapy 18 (12): 1249–1270. December 2018. doi:10.1080/14737140.2018.1527688. PMID 30259761.
«Current and future status of JAK inhibitors». Lancet 398 (10302): 803–816. August 2021. doi:10.1016/S0140-6736(21)00438-4. PMID 34454676.
«Anticancer antifolates: current status and future directions». Current Pharmaceutical Design 9 (31): 2593–2613. 2003. doi:10.2174/1381612033453712. PMID 14529544.
«The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction». Sexual Medicine Reviews 7 (1): 115–128. January 2019. doi:10.1016/j.sxmr.2018.06.005. PMID 30301707.
«Erectile dysfunction: from biochemical pharmacology to advances in medical therapy». European Journal of Endocrinology 143 (2): 143–154. August 2000. doi:10.1530/eje.0.1430143. PMID 10913932.
«Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases». European Journal of Medicinal Chemistry 194: 112262. May 2020. doi:10.1016/j.ejmech.2020.112262. PMID 32248005. https://pure.qub.ac.uk/en/publications/breaking-down-the-cell-wall-strategies-for-antibiotic-discovery-targeting-bacterial-transpeptidases(e1bd1fbf-37a6-44ce-afdf-cc255bf217e6).html. Ανακτήθηκε στις 20 July 2022.
«Cutting and stitching: the cross-linking of peptidoglycan in the assembly of the bacterial cell wall». ACS Chemical Biology 2 (9): 602–5. September 2007. doi:10.1021/cb700182u. PMID 17894443.
«Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore risks?». Infection 49 (1): 29–56. February 2021. doi:10.1007/s15010-020-01536-y. PMID 33367978.
«Ribosome-targeting antibacterial agents: Advances, challenges, and opportunities». Medicinal Research Reviews 41 (4): 1855–1889. July 2021. doi:10.1002/med.21780. PMID 33501747.
«Bacterial fatty acid metabolism in modern antibiotic discovery». Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862 (11): 1300–1309. November 2017. doi:10.1016/j.bbalip.2016.09.014. PMID 27668701.
«Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges». Current Topics in Medicinal Chemistry 19 (18): 1571–1598. 2019. doi:10.2174/1568026619666190619115243. PMID 31237209.
«Protease inhibitor therapy for hepatitis C virus-infection». Expert Opinion on Pharmacotherapy 19 (6): 577–587. April 2018. doi:10.1080/14656566.2018.1454428. PMID 29595065.
«Approved HIV reverse transcriptase inhibitors in the past decade». Acta Pharmaceutica Sinica B 12 (4): 1567–1590. April 2022. doi:10.1016/j.apsb.2021.11.009. PMID 35847492.
«Antivirals Targeting the Neuraminidase». Cold Spring Harbor Perspectives in Medicine 12 (1): a038455. January 2022. doi:10.1101/cshperspect.a038455. PMID 32152244.
«Targeting the terminase: An important step forward in the treatment and prophylaxis of human cytomegalovirus infections». Antiviral Research 161: 116–124. January 2019. doi:10.1016/j.antiviral.2018.11.005. PMID 30472161.
«Treatment of Myasthenia Gravis». Neurologic Clinics 36 (2): 311–337. May 2018. doi:10.1016/j.ncl.2018.01.011. PMID 29655452.
«Acetylcholinesterase: A Primary Target for Drugs and Insecticides». Mini Reviews in Medicinal Chemistry 17 (17): 1665–1676. 2017. doi:10.2174/1389557517666170120153930. PMID 28117022.
«Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops». Amino Acids 30 (2): 195–204. March 2006. doi:10.1007/s00726-005-0254-1. PMID 16547651.
«Overview of herbicide mechanisms of action». Environmental Health Perspectives 87: 263–271. July 1990. doi:10.2307/3431034. PMID 1980104. PMC 1567841. https://archive.org/details/sim_environmental-health-perspectives_1990-07_87/page/263.
«Drug discovery for enzymes». Drug Discovery Today 26 (4): 875–886. April 2021. doi:10.1016/j.drudis.2021.01.006. PMID 33454380.
«Structural biology and drug discovery». Current Pharmaceutical Design 12 (17): 2087–2097. 2006. doi:10.2174/138161206777585201. PMID 16796557.
«Approaches to the description and prediction of the binding affinity of small-molecule ligands to macromolecular receptors». Angewandte Chemie 41 (15): 2644–2676. August 2002. doi:10.1002/1521-3773(20020802)41:15<2644::AID-ANIE2644>3.0.CO;2-O. PMID 12203463.
«Automated medicinal chemistry». Drug Discovery Today 11 (11–12): 561–568. June 2006. doi:10.1016/j.drudis.2006.04.005. PMID 16713909.
«Fragment-based approaches to enzyme inhibition». Current Opinion in Biotechnology 18 (6): 489–96. December 2007. doi:10.1016/j.copbio.2007.09.003. PMID 17959370.
«Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets». Bioorganic & Medicinal Chemistry Letters 39: 127851. May 2021. doi:10.1016/j.bmcl.2021.127851. PMID 33631371.
«Covalent Docking in Drug Discovery: Scope and Limitations». Current Pharmaceutical Design 26 (44): 5684–5699. 2020. doi:10.2174/1381612824999201105164942. PMID 33155894.
«Mechanisms of Proteolytic Enzymes and Their Inhibition in QM/MM Studies». International Journal of Molecular Sciences 22 (6): 3232. March 2021. doi:10.3390/ijms22063232. PMID 33810118.

doi.org

Copeland RA (Μαρτίου 2013). «Why Enzymes as Drug Targets? Enzyme are Essential for Life». Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (Second έκδοση). John Wiley & Sons, Inc. σελίδες 1–23. doi:10.1002/9781118540398.ch1. ISBN 978-1-118-48813-3.
Palmer T, Bonner PL (2007). «Enzyme inhibition.». Enzymes: Biochemistry, Biotechnology, Clinical Chemistry (2nd έκδοση). Woodhead Publishing. σελίδες 126–152 (135). doi:10.1533/9780857099921.2.126. ISBN 978-1-904275-27-5.
Radzicka A, Wolfenden R (1995). «Transition state and multisubstrate analog inhibitors». Enzyme Kinetics and Mechanism Part D: Developments in Enzyme Dynamics. Methods in Enzymology. 249. σελίδες 284–312. doi:10.1016/0076-6879(95)49039-6. ISBN 9780121821500. PMID 7791615.
Szedlacsek SE, Duggleby RG (1995). «[6] Kinetics of slow and tight-binding inhibitors». Kinetics of slow and tight-binding inhibitors. Methods in Enzymology. 249. σελίδες 144–80. doi:10.1016/0076-6879(95)49034-5. ISBN 978-0-12-182150-0. PMID 7791610.
Cohen JA, Oosterbaan RA, Berends F (1967). «[81] Organophosphorus compounds». Enzyme Structure. Methods in Enzymology. 11. σελίδες 686–702. doi:10.1016/S0076-6879(67)11085-9. ISBN 978-0-12-181860-9. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Φεβρουαρίου 2018.
Savage GP, Morrison SC (2003). «Trypsin inhibitors.». Στο: Caballero B, επιμ. Encyclopedia of Food Sciences and Nutrition (Second έκδοση). Academic Press. σελίδες 5878–5884. doi:10.1016/B0-12-227055-X/00934-2. ISBN 978-0-12-227055-0.
Li G, Jing X, Pan, Zhang P, De Clercq E (2021). «Antiviral Classification». Στο: Bamford D, Zuckerman MA, επιμ. Encyclopedia of Virology. 5 (4th έκδοση). Amsterdam: Academic Press. σελίδες 129–130. doi:10.1016/B978-0-12-814515-9.00126-0 . ISBN 978-0-12-814516-6. OCLC 1240584737.
Hirai K, Uchida A, Ohno R (2012). «Major Synthetic Routes for Modern Herbicide Classes and Agrochemical Characteristics». Στο: Böger P, Wakabayashi K, Hirai K, επιμ. Herbicide Classes in Development. Springer Science & Business Media. σελίδες 179–195. doi:10.1007/978-3-642-59416-8_10. ISBN 978-3-642-59416-8. Αρχειοθετήθηκε από το πρωτότυπο στις 27 Ιουνίου 2022. Ανακτήθηκε στις 27 Ιουνίου 2022. Chapter 10.2.1: Sulfonylurea acetolactate synthase inhibitors

dtic.mil

oai.dtic.mil

Cohen JA, Oosterbaan RA, Berends F (1967). «[81] Organophosphorus compounds». Enzyme Structure. Methods in Enzymology. 11. σελίδες 686–702. doi:10.1016/S0076-6879(67)11085-9. ISBN 978-0-12-181860-9. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Φεβρουαρίου 2018.

harvard.edu

adsabs.harvard.edu

«Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators». PLOS ONE 14 (3): e0214255. 2019. doi:10.1371/journal.pone.0214255. PMID 30917186. Bibcode: 2019PLoSO..1414255J.
«A comparison of the parameter estimating procedures for the Michaelis-Menten model». Journal of Theoretical Biology 145 (4): 457–464. August 1990. doi:10.1016/S0022-5193(05)80481-3. PMID 2246896. Bibcode: 1990JThBi.145..457T.
«Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis». Science 279 (5347): 98–102. January 1998. doi:10.1126/science.279.5347.98. PMID 9417034. Bibcode: 1998Sci...279...98R.
«Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124». Proceedings of the National Academy of Sciences of the United States of America 107 (11): 4878–4883. March 2010. doi:10.1073/pnas.0909141107. PMID 20194791. Bibcode: 2010PNAS..107.4878A.

mhmedical.com

accessanesthesiology.mhmedical.com

Butterworth JF, IV, Mackey DC, Wasnick JD, επιμ. (2013). «Chapter 12. Cholinesterase Inhibitors & Other Pharmacologic Antagonists to Neuromuscular Blocking Agents.». Morgan & Mikhail's Clinical Anesthesiology (5th έκδοση). McGraw Hill. Αρχειοθετήθηκε από το πρωτότυπο στις 30 Ιουνίου 2022. Ανακτήθηκε στις 9 Απριλίου 2022.

nih.gov

ncbi.nlm.nih.gov

«Control and regulation of pathways via negative feedback». Journal of the Royal Society, Interface 14 (127): 1–13. February 2017. doi:10.1098/rsif.2016.0848. PMID 28202588.
«Drugs from the deep: marine natural products as drug candidates». Drug Discovery Today 8 (12): 536–44. June 2003. doi:10.1016/s1359-6446(03)02713-2. PMID 12821301.
«SERPINs-From Trap to Treatment». Frontiers in Medicine 6: 25. 2019. doi:10.3389/fmed.2019.00025. PMID 30809526.
«Interaction of human placental ribonuclease with placental ribonuclease inhibitor». Biochemistry 30 (8): 2246–2255. February 1991. doi:10.1021/bi00222a030. PMID 1998683.
«Protease propeptide structures, mechanisms of activation, and functions». Critical Reviews in Biochemistry and Molecular Biology 55 (2): 111–165. April 2020. doi:10.1080/10409238.2020.1742090. PMID 32290726.
«Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators». PLOS ONE 14 (3): e0214255. 2019. doi:10.1371/journal.pone.0214255. PMID 30917186. Bibcode: 2019PLoSO..1414255J.
«The Taxonomy of Covalent Inhibitors». Biochemistry 57 (24): 3326–3337. June 2018. doi:10.1021/acs.biochem.8b00315. PMID 29689165.
«The kinetics of enzyme-catalysed reactions with two or more substrates or products. II. Inhibition: nomenclature and theory». Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects 67: 173–187. February 1963. doi:10.1016/0926-6569(63)90226-8. PMID 14021668.
Berg J, Tymoczko J, Stryer L (2002). Biochemistry. W. H. Freeman and Company. ISBN 978-0-7167-4955-4. Αρχειοθετήθηκε από το πρωτότυπο στις 26 Σεπτεμβρίου 2009. Ανακτήθηκε στις 31 Αυγούστου 2017.
Delaune KP, Alsayouri K (Σεπτεμβρίου 2021). «Physiology: Noncompetitive Inhibitor». StatPearls. Treasure Island (FL): StatPearls Publishing. σελ. 31424826. PMID 31424826. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Νοεμβρίου 2021. Ανακτήθηκε στις 3 Απριλίου 2022.
«Enzyme-Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality». SLAS Discovery: Advancing Life Sciences R & D 24 (5): 515–522 (516). June 2019. doi:10.1177/2472555219829898. PMID 30811960. «In some cases, the inhibitor may bind to a distinct site on the enzyme that is in allosteric communication with the substrate binding pocket. In many cases, allosteric, substrate competitive compounds result in conformational changes to the enzyme that change the ability of the enzyme to bind substrate.».
«Limitations of conventional inhibitor classifications». Integrative Biology 3 (12): 1197–1201. December 2011. doi:10.1039/c1ib00053e. PMID 22038120.
«A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase». Biochimica et Biophysica Acta (BBA) - General Subjects 1770 (5): 733–746. May 2007. doi:10.1016/j.bbagen.2007.01.001. PMID 17307293.
Strelow J, Dewe W, Iversen PW, Brooks PB, Radding JA, McGee J, Weidner J (Οκτωβρίου 2012). «Mechanism of Action Assays for Enzymes». Στο: Markossian S, Grossman A, Brimacombe K, και άλλοι., επιμ. Assay Guidance Manual. Eli Lilly & Company and the National Center for Advancing Translational Sciences. PMID 22553872. Αρχειοθετήθηκε από το πρωτότυπο στις 15 Ιουνίου 2022. Ανακτήθηκε στις 9 Απριλίου 2022.
«Making cool drugs hot: isothermal titration calorimetry as a tool to study binding energetics». BioTechniques 31 (1): 164–6, 168, 170 passim. July 2001. PMID 11464510.
«Using linear and non-linear regression to fit biochemical data». Trends in Biochemical Sciences 15 (12): 455–458. December 1990. doi:10.1016/0968-0004(90)90295-M. PMID 2077683.
«A comparison of the parameter estimating procedures for the Michaelis-Menten model». Journal of Theoretical Biology 145 (4): 457–464. August 1990. doi:10.1016/S0022-5193(05)80481-3. PMID 2246896. Bibcode: 1990JThBi.145..457T.
Radzicka A, Wolfenden R (1995). «Transition state and multisubstrate analog inhibitors». Enzyme Kinetics and Mechanism Part D: Developments in Enzyme Dynamics. Methods in Enzymology. 249. σελίδες 284–312. doi:10.1016/0076-6879(95)49039-6. ISBN 9780121821500. PMID 7791615.
«Amylase/creatinine clearance fraction in patients on chronic hemodialysis». Annals of Internal Medicine 86 (1): 65–66. January 1977. doi:10.7326/0003-4819-86-1-65. PMID 319722. https://archive.org/details/sim_annals-of-internal-medicine_1977-01_86_1/page/65.
«A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant». Journal of Medicinal Chemistry 32 (5): 937–940. May 1989. doi:10.1021/jm00125a002. PMID 2709379.
«Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis». Science 279 (5347): 98–102. January 1998. doi:10.1126/science.279.5347.98. PMID 9417034. Bibcode: 1998Sci...279...98R.
«Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124». Proceedings of the National Academy of Sciences of the United States of America 107 (11): 4878–4883. March 2010. doi:10.1073/pnas.0909141107. PMID 20194791. Bibcode: 2010PNAS..107.4878A.
«Multisubstrate adduct inhibitors: drug design and biological tools». Journal of Enzyme Inhibition and Medicinal Chemistry 24 (6): 1291–318. December 2009. doi:10.3109/14756360902843809. PMID 19912064.
«Antiviral drug discovery targeting to viral proteases». Current Pharmaceutical Design 12 (11): 1301–1314. 2006. doi:10.2174/138161206776361110. PMID 16611117.
«Proteases and protease inhibitors in infectious diseases». Medicinal Research Reviews 38 (4): 1295–1331. July 2018. doi:10.1002/med.21475. PMID 29149530.
«Recent developments of peptidomimetic HIV-1 protease inhibitors». Current Medicinal Chemistry 18 (29): 4513–37. 2011. doi:10.2174/092986711797287566. PMID 21864279.
«Enzymatic Transition States and Drug Design». Chemical Reviews 118 (22): 11194–11258. November 2018. doi:10.1021/acs.chemrev.8b00369. PMID 30335982.
«Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor». Current Medicinal Chemistry 7 (6): 663–672. June 2000. doi:10.2174/0929867003374886. PMID 10702632.
«The design, synthesis and application of stereochemical and directional peptide isomers: a critical review». Current Protein & Peptide Science 4 (5): 339–356. October 2003. doi:10.2174/1389203033487054. PMID 14529528.
«Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges». ACS Chemical Biology 10 (1): 175–89. January 2015. doi:10.1021/cb5008376. PMID 25494294.
«Peptide inhibitors of protein kinases-discovery, characterisation and use». Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1754 (1–2): 79–99. December 2005. doi:10.1016/j.bbapap.2005.07.025. PMID 16182621.
«Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology». Journal of Medicinal Chemistry 62 (12): 5673–5724. June 2019. doi:10.1021/acs.jmedchem.8b01153. PMID 30565923.
«Profiling the specific reactivity of the proteome with non-directed activity-based probes». Chemistry & Biology 8 (1): 81–95. January 2001. doi:10.1016/S1074-5521(00)90060-7. PMID 11182321.
«Comparison of methods for analyzing kinetic data from mechanism-based enzyme inactivation: application to nitric oxide synthase». AAPS PharmSci 2 (1): 68–77. 2000. doi:10.1208/ps020108. PMID 11741224.
«Application of mass spectrometry for target identification and characterization». Medicinal Research Reviews 19 (4): 307–319. July 1999. doi:10.1002/(SICI)1098-1128(199907)19:4<307::AID-MED4>3.0.CO;2-2. PMID 10398927. https://archive.org/details/sim_medicinal-research-reviews_1999-07_19_4/page/307.
«Development of a matrix-assisted laser desorption/ionization-mass spectrometry screening test to evidence reversible and irreversible inhibitors of CDC25 phosphatases». Analytical Biochemistry 430 (1): 83–91. November 2012. doi:10.1016/j.ab.2012.08.006. PMID 22902804.
«Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites». The Journal of Biological Chemistry 267 (1): 150–158. January 1992. doi:10.1016/S0021-9258(18)48472-4. PMID 1730582.
Szedlacsek SE, Duggleby RG (1995). «[6] Kinetics of slow and tight-binding inhibitors». Kinetics of slow and tight-binding inhibitors. Methods in Enzymology. 249. σελίδες 144–80. doi:10.1016/0076-6879(95)49034-5. ISBN 978-0-12-182150-0. PMID 7791610.
«Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogs». Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 869 (3): 275–285. February 1986. doi:10.1016/0167-4838(86)90067-1. PMID 3511964.
«Reaction of formaldehyde and of methanol with xanthine oxidase». European Journal of Biochemistry 18 (1): 65–72. January 1971. doi:10.1111/j.1432-1033.1971.tb01215.x. PMID 4322209.
«Herpes simplex virus type 1 and human DNA polymerase interactions with 2'-deoxyguanosine 5'-triphosphate analogs. Kinetics of incorporation into DNA and induction of inhibition». The Journal of Biological Chemistry 264 (32): 19039–19044. November 1989. doi:10.1016/S0021-9258(19)47263-3. PMID 2553730.
PDB: 1GXF; «Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design». The Journal of Biological Chemistry 279 (28): 29493–500. July 2004. doi:10.1074/jbc.M403187200. PMID 15102853.
«Suicide substrates, mechanism-based enzyme inactivators: recent developments». Annual Review of Biochemistry 53: 493–535. 1984. doi:10.1146/annurev.bi.53.070184.002425. PMID 6433782. https://archive.org/details/sim_annual-review-of-biochemistry_1984_53_annual/page/493.
«Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design». The Journal of Biological Chemistry 279 (28): 29493–29500. July 2004. doi:10.1074/jbc.M403187200. PMID 15102853.
«Enzyme inhibitors as chemical tools to study enzyme catalysis: rational design, synthesis, and applications». Chemical Record (New York, N.Y.) 5 (4): 209–28. 2005. doi:10.1002/tcr.20045. PMID 16041744.
Greathouse B, Zahra F, Brady MF (Σεπτεμβρίου 2021). «Acetylcholinesterase Inhibitors Toxicity». StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30571049. Αρχειοθετήθηκε από το πρωτότυπο στις 17 Ιανουαρίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
«Fructose-2,6-bisphosphate and control of carbohydrate metabolism in eukaryotes». BioFactors 10 (1): 1–14. 1999. doi:10.1002/biof.5520100101. PMID 10475585.
«Substrate variants versus transition state analogues as noncovalent reversible enzyme inhibitors». Bioorganic & Medicinal Chemistry 12 (15): 4081–4088. August 2004. doi:10.1016/j.bmc.2004.05.041. PMID 15246086. https://zenodo.org/record/998967. Ανακτήθηκε στις 14 April 2022.
«Barnase and barstar: two small proteins to fold and fit together». Trends in Biochemical Sciences 14 (11): 450–454. November 1989. doi:10.1016/0968-0004(89)90104-7. PMID 2696173.
«Biodiversity as a source of anticancer drugs». Current Drug Targets 7 (3): 265–277. March 2006. doi:10.2174/138945006776054942. PMID 16515527.
«Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action». Current Cancer Drug Targets 3 (3): 193–203. June 2003. doi:10.2174/1568009033481967. PMID 12769688.
«A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia». Dementia and Geriatric Cognitive Disorders 45 (3–4): 131–151. 2018. doi:10.1159/000486546. PMID 29734182.
«Antimuscarinic intoxication resulting from the ingestion of moonflower seeds». The Annals of Pharmacotherapy 39 (1): 173–176. January 2005. doi:10.1345/aph.1D536. PMID 15572604. https://archive.org/details/sim_annals-of-pharmacotherapy_2005-01_39_1/page/173.
«Toxins of Amanita phalloides». Toxicon 36 (1): 13–24. January 1998. doi:10.1016/S0041-0101(97)00074-3. PMID 9604278. https://archive.org/details/sim_toxicon_1998-01_36_1/page/13.
«Molecular enzymology underlying regulation of protein phosphatase-1 by natural toxins». Current Medicinal Chemistry 9 (22): 1981–1989. November 2002. doi:10.2174/0929867023368827. PMID 12369866.
«The toxicology of microcystin-LR: occurrence, toxicokinetics, toxicodynamics, diagnosis and treatment». Veterinary and Human Toxicology 43 (5): 294–297. October 2001. PMID 11577938.
«Ricin: An Ancient Story for a Timeless Plant Toxin». Toxins 11 (6): 324. June 2019. doi:10.3390/toxins11060324. PMID 31174319.
«Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin». Toxins 11 (6): 350. June 2019. doi:10.3390/toxins11060350. PMID 31216687.
«Cytotoxic ribosome-inactivating lectins from plants». Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1701 (1–2): 1–14. September 2004. doi:10.1016/j.bbapap.2004.06.004. PMID 15450171.
«A comprehensive map of molecular drug targets». Nature Reviews. Drug Discovery 16 (1): 19–34 (Figure 1C). January 2017. doi:10.1038/nrd.2016.230. PMID 27910877. «Figure 1C: Clinical success of privileged protein family classes (% approved drugs targeting each target class): Reductase 7.62, Kinase 5.94, Protease 3.35, Hydrolase 2.76, NPTase 2.09, Transferase 1.92, Lyase 1.59, Isomerase 1.51, Phosphodiesterase 1.50, Cytochrome p450 0.84, Epigenetic eraser 0.33, Total enzyme targets of approved drugs = 29.45%».
«A comprehensive review of protein kinase inhibitors for cancer therapy». Expert Review of Anticancer Therapy 18 (12): 1249–1270. December 2018. doi:10.1080/14737140.2018.1527688. PMID 30259761.
«Current and future status of JAK inhibitors». Lancet 398 (10302): 803–816. August 2021. doi:10.1016/S0140-6736(21)00438-4. PMID 34454676.
«Anticancer antifolates: current status and future directions». Current Pharmaceutical Design 9 (31): 2593–2613. 2003. doi:10.2174/1381612033453712. PMID 14529544.
«The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction». Sexual Medicine Reviews 7 (1): 115–128. January 2019. doi:10.1016/j.sxmr.2018.06.005. PMID 30301707.
«Erectile dysfunction: from biochemical pharmacology to advances in medical therapy». European Journal of Endocrinology 143 (2): 143–154. August 2000. doi:10.1530/eje.0.1430143. PMID 10913932.
«Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases». European Journal of Medicinal Chemistry 194: 112262. May 2020. doi:10.1016/j.ejmech.2020.112262. PMID 32248005. https://pure.qub.ac.uk/en/publications/breaking-down-the-cell-wall-strategies-for-antibiotic-discovery-targeting-bacterial-transpeptidases(e1bd1fbf-37a6-44ce-afdf-cc255bf217e6).html. Ανακτήθηκε στις 20 July 2022.
«Cutting and stitching: the cross-linking of peptidoglycan in the assembly of the bacterial cell wall». ACS Chemical Biology 2 (9): 602–5. September 2007. doi:10.1021/cb700182u. PMID 17894443.
«Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore risks?». Infection 49 (1): 29–56. February 2021. doi:10.1007/s15010-020-01536-y. PMID 33367978.
«How do antibiotics kill bacterial cells but not human cells?». Scientific American 294 (6): 98. 13 March 2006. PMID 16711368. https://www.scientificamerican.com/article/how-do-antibiotics-kill-b/. Ανακτήθηκε στις 9 April 2022.
«Ribosome-targeting antibacterial agents: Advances, challenges, and opportunities». Medicinal Research Reviews 41 (4): 1855–1889. July 2021. doi:10.1002/med.21780. PMID 33501747.
«Bacterial fatty acid metabolism in modern antibiotic discovery». Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862 (11): 1300–1309. November 2017. doi:10.1016/j.bbalip.2016.09.014. PMID 27668701.
«Protease Inhibitors for the Treatment of HIV/AIDS: Recent Advances and Future Challenges». Current Topics in Medicinal Chemistry 19 (18): 1571–1598. 2019. doi:10.2174/1568026619666190619115243. PMID 31237209.
«Protease inhibitor therapy for hepatitis C virus-infection». Expert Opinion on Pharmacotherapy 19 (6): 577–587. April 2018. doi:10.1080/14656566.2018.1454428. PMID 29595065.
«Approved HIV reverse transcriptase inhibitors in the past decade». Acta Pharmaceutica Sinica B 12 (4): 1567–1590. April 2022. doi:10.1016/j.apsb.2021.11.009. PMID 35847492.
«Antivirals Targeting the Neuraminidase». Cold Spring Harbor Perspectives in Medicine 12 (1): a038455. January 2022. doi:10.1101/cshperspect.a038455. PMID 32152244.
«Targeting the terminase: An important step forward in the treatment and prophylaxis of human cytomegalovirus infections». Antiviral Research 161: 116–124. January 2019. doi:10.1016/j.antiviral.2018.11.005. PMID 30472161.
«Treatment of Myasthenia Gravis». Neurologic Clinics 36 (2): 311–337. May 2018. doi:10.1016/j.ncl.2018.01.011. PMID 29655452.
«Acetylcholinesterase: A Primary Target for Drugs and Insecticides». Mini Reviews in Medicinal Chemistry 17 (17): 1665–1676. 2017. doi:10.2174/1389557517666170120153930. PMID 28117022.
«Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops». Amino Acids 30 (2): 195–204. March 2006. doi:10.1007/s00726-005-0254-1. PMID 16547651.
«Overview of herbicide mechanisms of action». Environmental Health Perspectives 87: 263–271. July 1990. doi:10.2307/3431034. PMID 1980104. PMC 1567841. https://archive.org/details/sim_environmental-health-perspectives_1990-07_87/page/263.
«Drug discovery for enzymes». Drug Discovery Today 26 (4): 875–886. April 2021. doi:10.1016/j.drudis.2021.01.006. PMID 33454380.
«Structural biology and drug discovery». Current Pharmaceutical Design 12 (17): 2087–2097. 2006. doi:10.2174/138161206777585201. PMID 16796557.
«Approaches to the description and prediction of the binding affinity of small-molecule ligands to macromolecular receptors». Angewandte Chemie 41 (15): 2644–2676. August 2002. doi:10.1002/1521-3773(20020802)41:15<2644::AID-ANIE2644>3.0.CO;2-O. PMID 12203463.
«Automated medicinal chemistry». Drug Discovery Today 11 (11–12): 561–568. June 2006. doi:10.1016/j.drudis.2006.04.005. PMID 16713909.
«Fragment-based approaches to enzyme inhibition». Current Opinion in Biotechnology 18 (6): 489–96. December 2007. doi:10.1016/j.copbio.2007.09.003. PMID 17959370.
«Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets». Bioorganic & Medicinal Chemistry Letters 39: 127851. May 2021. doi:10.1016/j.bmcl.2021.127851. PMID 33631371.
«Covalent Docking in Drug Discovery: Scope and Limitations». Current Pharmaceutical Design 26 (44): 5684–5699. 2020. doi:10.2174/1381612824999201105164942. PMID 33155894.
«Mechanisms of Proteolytic Enzymes and Their Inhibition in QM/MM Studies». International Journal of Molecular Sciences 22 (6): 3232. March 2021. doi:10.3390/ijms22063232. PMID 33810118.

pubmedcentral.nih.gov

«Control and regulation of pathways via negative feedback». Journal of the Royal Society, Interface 14 (127): 1–13. February 2017. doi:10.1098/rsif.2016.0848. PMID 28202588.
«SERPINs-From Trap to Treatment». Frontiers in Medicine 6: 25. 2019. doi:10.3389/fmed.2019.00025. PMID 30809526.
«Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators». PLOS ONE 14 (3): e0214255. 2019. doi:10.1371/journal.pone.0214255. PMID 30917186. Bibcode: 2019PLoSO..1414255J.
«The Taxonomy of Covalent Inhibitors». Biochemistry 57 (24): 3326–3337. June 2018. doi:10.1021/acs.biochem.8b00315. PMID 29689165.
«Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124». Proceedings of the National Academy of Sciences of the United States of America 107 (11): 4878–4883. March 2010. doi:10.1073/pnas.0909141107. PMID 20194791. Bibcode: 2010PNAS..107.4878A.
«Enzymatic Transition States and Drug Design». Chemical Reviews 118 (22): 11194–11258. November 2018. doi:10.1021/acs.chemrev.8b00369. PMID 30335982.
«Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges». ACS Chemical Biology 10 (1): 175–89. January 2015. doi:10.1021/cb5008376. PMID 25494294.
«Comparison of methods for analyzing kinetic data from mechanism-based enzyme inactivation: application to nitric oxide synthase». AAPS PharmSci 2 (1): 68–77. 2000. doi:10.1208/ps020108. PMID 11741224.
PDB: 1GXF; «Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design». The Journal of Biological Chemistry 279 (28): 29493–500. July 2004. doi:10.1074/jbc.M403187200. PMID 15102853.
«Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design». The Journal of Biological Chemistry 279 (28): 29493–29500. July 2004. doi:10.1074/jbc.M403187200. PMID 15102853.
«Ricin: An Ancient Story for a Timeless Plant Toxin». Toxins 11 (6): 324. June 2019. doi:10.3390/toxins11060324. PMID 31174319.
«Intracellular Transport and Cytotoxicity of the Protein Toxin Ricin». Toxins 11 (6): 350. June 2019. doi:10.3390/toxins11060350. PMID 31216687.
«A comprehensive map of molecular drug targets». Nature Reviews. Drug Discovery 16 (1): 19–34 (Figure 1C). January 2017. doi:10.1038/nrd.2016.230. PMID 27910877. «Figure 1C: Clinical success of privileged protein family classes (% approved drugs targeting each target class): Reductase 7.62, Kinase 5.94, Protease 3.35, Hydrolase 2.76, NPTase 2.09, Transferase 1.92, Lyase 1.59, Isomerase 1.51, Phosphodiesterase 1.50, Cytochrome p450 0.84, Epigenetic eraser 0.33, Total enzyme targets of approved drugs = 29.45%».
«A comprehensive review of protein kinase inhibitors for cancer therapy». Expert Review of Anticancer Therapy 18 (12): 1249–1270. December 2018. doi:10.1080/14737140.2018.1527688. PMID 30259761.
«Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore risks?». Infection 49 (1): 29–56. February 2021. doi:10.1007/s15010-020-01536-y. PMID 33367978.
«Bacterial fatty acid metabolism in modern antibiotic discovery». Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1862 (11): 1300–1309. November 2017. doi:10.1016/j.bbalip.2016.09.014. PMID 27668701.
«Approved HIV reverse transcriptase inhibitors in the past decade». Acta Pharmaceutica Sinica B 12 (4): 1567–1590. April 2022. doi:10.1016/j.apsb.2021.11.009. PMID 35847492.
«Antivirals Targeting the Neuraminidase». Cold Spring Harbor Perspectives in Medicine 12 (1): a038455. January 2022. doi:10.1101/cshperspect.a038455. PMID 32152244.
«Treatment of Myasthenia Gravis». Neurologic Clinics 36 (2): 311–337. May 2018. doi:10.1016/j.ncl.2018.01.011. PMID 29655452.
«Overview of herbicide mechanisms of action». Environmental Health Perspectives 87: 263–271. July 1990. doi:10.2307/3431034. PMID 1980104. PMC 1567841. https://archive.org/details/sim_environmental-health-perspectives_1990-07_87/page/263.
«Fragment-based approaches to enzyme inhibition». Current Opinion in Biotechnology 18 (6): 489–96. December 2007. doi:10.1016/j.copbio.2007.09.003. PMID 17959370.
«Mechanisms of Proteolytic Enzymes and Their Inhibition in QM/MM Studies». International Journal of Molecular Sciences 22 (6): 3232. March 2021. doi:10.3390/ijms22063232. PMID 33810118.

assay.nih.gov

«Types of Inhibition». NIH Center for Translational Therapeutics. Αρχειοθετήθηκε από το πρωτότυπο στις 8 Σεπτεμβρίου 2011. Ανακτήθηκε στις 2 Απριλίου 2012.

qub.ac.uk

pure.qub.ac.uk

«Breaking down the cell wall: Strategies for antibiotic discovery targeting bacterial transpeptidases». European Journal of Medicinal Chemistry 194: 112262. May 2020. doi:10.1016/j.ejmech.2020.112262. PMID 32248005. https://pure.qub.ac.uk/en/publications/breaking-down-the-cell-wall-strategies-for-antibiotic-discovery-targeting-bacterial-transpeptidases(e1bd1fbf-37a6-44ce-afdf-cc255bf217e6).html. Ανακτήθηκε στις 20 July 2022.

rcsb.org

PDB: 1GXF; «Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design». The Journal of Biological Chemistry 279 (28): 29493–500. July 2004. doi:10.1074/jbc.M403187200. PMID 15102853.

scientificamerican.com

«How do antibiotics kill bacterial cells but not human cells?». Scientific American 294 (6): 98. 13 March 2006. PMID 16711368. https://www.scientificamerican.com/article/how-do-antibiotics-kill-b/. Ανακτήθηκε στις 9 April 2022.

web.archive.org

Plaxton WC (2004). «Principles of Metabolic Control». Στο: Storey KB, επιμ. Functional Metabolism: Regulation and Adaptation. Hoboken, N.J.: John Wiley & Sons. σελίδες 1–24 (12). ISBN 978-0-471-67557-0. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
Rydzewski RM (2010). «Chapter 7.2.1: Competition and Allostery». Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research (1st έκδοση). Amsterdam: Elsevier. σελίδες 281–285. ISBN 978-0-08-091488-6. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 20 Ιουλίου 2022.
Patrick GL (2013). «Chapter 7: Enzymes as Drug Targets». An Introduction to Medicinal Chemistry (Fifth έκδοση). Oxford, UK: Oxford University Press. σελ. 90. ISBN 978-0-19-969739-7. Αρχειοθετήθηκε από το πρωτότυπο στις 20 Ιουλίου 2022. Ανακτήθηκε στις 20 Ιουλίου 2022.
Kuriyan J, Konforti B, Wemmer D (2012). «Molecular Recognition: The Thermodynamics of Binding». The Molecules of Life : Physical and Chemical Principles (First έκδοση). Boca Raton, FL: Garland Science. σελίδες 531–580. ISBN 978-1-135-08892-7. Αρχειοθετήθηκε από το πρωτότυπο στις 7 Ιουνίου 2022. Ανακτήθηκε στις 7 Ιουνίου 2022.
Berg J, Tymoczko J, Stryer L (2002). Biochemistry. W. H. Freeman and Company. ISBN 978-0-7167-4955-4. Αρχειοθετήθηκε από το πρωτότυπο στις 26 Σεπτεμβρίου 2009. Ανακτήθηκε στις 31 Αυγούστου 2017.
«Types of Inhibition». NIH Center for Translational Therapeutics. Αρχειοθετήθηκε από το πρωτότυπο στις 8 Σεπτεμβρίου 2011. Ανακτήθηκε στις 2 Απριλίου 2012.
Delaune KP, Alsayouri K (Σεπτεμβρίου 2021). «Physiology: Noncompetitive Inhibitor». StatPearls. Treasure Island (FL): StatPearls Publishing. σελ. 31424826. PMID 31424826. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Νοεμβρίου 2021. Ανακτήθηκε στις 3 Απριλίου 2022.
Strelow J, Dewe W, Iversen PW, Brooks PB, Radding JA, McGee J, Weidner J (Οκτωβρίου 2012). «Mechanism of Action Assays for Enzymes». Στο: Markossian S, Grossman A, Brimacombe K, και άλλοι., επιμ. Assay Guidance Manual. Eli Lilly & Company and the National Center for Advancing Translational Sciences. PMID 22553872. Αρχειοθετήθηκε από το πρωτότυπο στις 15 Ιουνίου 2022. Ανακτήθηκε στις 9 Απριλίου 2022.
Patrick GL (2017). «Enzymes as Drug Targets». An Introduction to Medicinal Chemistry (Sixth έκδοση). Oxford, United Kingdom: Oxford University Press. σελ. 95. ISBN 978-0-19-874969-1. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 3 Ιουνίου 2022.
Purich DL (2010). «Irreversible Enzyme Inhibition by Affinity Labelling Agents». Enzyme Kinetics: Catalysis and Control: A Reference of Theory and Best-Practice Methods. San Diego, Calif.: Elsevier Academic. σελ. 542. ISBN 978-0-12-380925-4. Αρχειοθετήθηκε από το πρωτότυπο στις 20 Ιουλίου 2022. Ανακτήθηκε στις 20 Ιουλίου 2022.
Cohen JA, Oosterbaan RA, Berends F (1967). «[81] Organophosphorus compounds». Enzyme Structure. Methods in Enzymology. 11. σελίδες 686–702. doi:10.1016/S0076-6879(67)11085-9. ISBN 978-0-12-181860-9. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Φεβρουαρίου 2018.
Pereira DM, Andrade C, Valentão P, Andrade PB (Οκτωβρίου 2017). «Natural products as enzyme inhibitors.» (PDF). Natural Products Targeting Clinically Relevant Enzymes (First έκδοση). Wiley-VCH Verlag GmbH & Co. KGaA. ISBN 978-3-527-34205-1. Αρχειοθετήθηκε (PDF) από το πρωτότυπο στις 5 Δεκεμβρίου 2022. Ανακτήθηκε στις 3 Απριλίου 2022.
Page C, Pitchford S (2021). «Venoms, toxins, poisons and herbs». Dale's Pharmacology Condensed E-Book (Third έκδοση). Philadelphia, Pa.: Elsevier Health Sciences. σελίδες 153–155. ISBN 978-0-7020-7819-4. Αρχειοθετήθηκε από το πρωτότυπο στις 25 Απριλίου 2013. Ανακτήθηκε στις 3 Ιουνίου 2022.
Stenersen J (2004). «Chapter 5: Specific Enzyme Inhibitors». Chemical Pesticides Mode of Action and Toxicology. Boca Raton: CRC Press. σελίδες 73–114. ISBN 978-0-203-64683-0. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
Greathouse B, Zahra F, Brady MF (Σεπτεμβρίου 2021). «Acetylcholinesterase Inhibitors Toxicity». StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30571049. Αρχειοθετήθηκε από το πρωτότυπο στις 17 Ιανουαρίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
Finkel R, Cubeddu LX, Clark MA (2009). «Chapter 41: Antiinfammatory Drugs». Pharmacology (4th έκδοση). Philadelphia: Lippincott Williams & Wilkins. σελίδες 499–518 (502). ISBN 978-0-7817-7155-9. Αρχειοθετήθηκε από το πρωτότυπο στις 28 Μαρτίου 2023. Ανακτήθηκε στις 14 Απριλίου 2022.
Gupta RC (2006). «Classification and Uses of Organophosphates and Carbamates». Στο: Gupta RC, επιμ. Toxicology of Organophosphate and Carbamate Compounds. Amsterdam: Elsevier Academic Press. σελίδες 5–24. ISBN 978-0-08-054310-9. Αρχειοθετήθηκε από το πρωτότυπο στις 21 Ιουλίου 2022. Ανακτήθηκε στις 21 Ιουλίου 2022.
Butterworth JF, IV, Mackey DC, Wasnick JD, επιμ. (2013). «Chapter 12. Cholinesterase Inhibitors & Other Pharmacologic Antagonists to Neuromuscular Blocking Agents.». Morgan & Mikhail's Clinical Anesthesiology (5th έκδοση). McGraw Hill. Αρχειοθετήθηκε από το πρωτότυπο στις 30 Ιουνίου 2022. Ανακτήθηκε στις 9 Απριλίου 2022.
Hirai K, Uchida A, Ohno R (2012). «Major Synthetic Routes for Modern Herbicide Classes and Agrochemical Characteristics». Στο: Böger P, Wakabayashi K, Hirai K, επιμ. Herbicide Classes in Development. Springer Science & Business Media. σελίδες 179–195. doi:10.1007/978-3-642-59416-8_10. ISBN 978-3-642-59416-8. Αρχειοθετήθηκε από το πρωτότυπο στις 27 Ιουνίου 2022. Ανακτήθηκε στις 27 Ιουνίου 2022. Chapter 10.2.1: Sulfonylurea acetolactate synthase inhibitors

wiley-vch.de

application.wiley-vch.de

Pereira DM, Andrade C, Valentão P, Andrade PB (Οκτωβρίου 2017). «Natural products as enzyme inhibitors.» (PDF). Natural Products Targeting Clinically Relevant Enzymes (First έκδοση). Wiley-VCH Verlag GmbH & Co. KGaA. ISBN 978-3-527-34205-1. Αρχειοθετήθηκε (PDF) από το πρωτότυπο στις 5 Δεκεμβρίου 2022. Ανακτήθηκε στις 3 Απριλίου 2022.

worldcat.org

Li G, Jing X, Pan, Zhang P, De Clercq E (2021). «Antiviral Classification». Στο: Bamford D, Zuckerman MA, επιμ. Encyclopedia of Virology. 5 (4th έκδοση). Amsterdam: Academic Press. σελίδες 129–130. doi:10.1016/B978-0-12-814515-9.00126-0 . ISBN 978-0-12-814516-6. OCLC 1240584737.

zenodo.org

«Substrate variants versus transition state analogues as noncovalent reversible enzyme inhibitors». Bioorganic & Medicinal Chemistry 12 (15): 4081–4088. August 2004. doi:10.1016/j.bmc.2004.05.041. PMID 15246086. https://zenodo.org/record/998967. Ανακτήθηκε στις 14 April 2022.