ATM serine/threonine kinase (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "ATM serine/threonine kinase" in English language version.

refsWebsite

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90nih.gov

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63doi.org

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17semanticscholar.org

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10harvard.edu

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3clinicaltrials.gov

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2ensembl.org

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2nature.com

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2worldcat.org

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1uniprot.org

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1dnatube.com

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1uq.edu.au

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clinicaltrials.gov

"CTG Labs - NCBI". clinicaltrials.gov. 16 September 2022. Retrieved 2023-08-29.
"CTG Labs - NCBI". clinicaltrials.gov. Retrieved 2023-08-29.
"CTG Labs - NCBI". clinicaltrials.gov. 18 July 2023. Retrieved 2023-08-29.

dnatube.com

Friedenson B (August 2007). "The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers". BMC Cancer. 7: 152. doi:10.1186/1471-2407-7-152. PMC 1959234. PMID 17683622.
- "The BRCA1/2 pathway prevents leukemias and lymphomas". Dnatube.

doi.org

Lee JH, Paull TT (December 2021). "Cellular functions of the protein kinase ATM and their relevance to human disease". Nature Reviews Molecular Cell Biology. 22 (12): 796–814. doi:10.1038/s41580-021-00394-2. ISSN 1471-0080. PMID 34429537. S2CID 237294441.
Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. (June 1995). "A single ataxia telangiectasia gene with a product similar to PI-3 kinase". Science. 268 (5218): 1749–53. Bibcode:1995Sci...268.1749S. doi:10.1126/science.7792600. PMID 7792600.
Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. (September 1998). "Enhanced phosphorylation of p53 by ATM in response to DNA damage". Science. 281 (5383): 1674–7. Bibcode:1998Sci...281.1674B. doi:10.1126/science.281.5383.1674. PMID 9733514.
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. (September 1998). "Activation of the ATM kinase by ionizing radiation and phosphorylation of p53". Science. 281 (5383): 1677–9. Bibcode:1998Sci...281.1677C. doi:10.1126/science.281.5383.1677. PMID 9733515.
Lee JH, Paull TT (December 2007). "Activation and regulation of ATM kinase activity in response to DNA double-strand breaks". Oncogene. 26 (56): 7741–8. doi:10.1038/sj.onc.1210872. PMID 18066086.
Stakyte K, Rotheneder M, Lammens K, Bartho JD, Grädler U, Fuchß T, et al. (October 2021). "Molecular basis of human ATM kinase inhibition". Nature Structural & Molecular Biology. 28 (10): 789–798. doi:10.1038/s41594-021-00654-x. ISSN 1545-9985. PMID 34556870. S2CID 237615473.
Lempiäinen H, Halazonetis TD (October 2009). "Emerging common themes in regulation of PIKKs and PI3Ks". The EMBO Journal. 28 (20): 3067–73. doi:10.1038/emboj.2009.281. PMC 2752028. PMID 19779456.
Huang X, Halicka HD, Darzynkiewicz Z (November 2004). "Detection of histone H2AX phosphorylation on Ser-139 as an indicator of DNA damage (DNA double-strand breaks)". Current Protocols in Cytometry. Chapter 7: Unit 7.27. doi:10.1002/0471142956.cy0727s30. ISBN 0-471-14295-6. PMID 18770804. S2CID 32281084.
Valentin-Vega YA, Maclean KH, Tait-Mulder J, Milasta S, Steeves M, Dorsey FC, et al. (February 2012). "Mitochondrial dysfunction in ataxia-telangiectasia". Blood. 119 (6): 1490–500. doi:10.1182/blood-2011-08-373639. PMC 3286212. PMID 22144182.
Datan E, Roy SG, Germain G, Zali N, McLean JE, Golshan G, et al. (March 2016). "Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation". Cell Death & Disease. 7 (e2127): e2127. doi:10.1038/cddis.2015.409. PMC 4823927. PMID 26938301.
Bakkenist CJ, Kastan MB (January 2003). "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation". Nature. 421 (6922): 499–506. Bibcode:2003Natur.421..499B. doi:10.1038/nature01368. PMID 12556884. S2CID 4403303.
Hall MJ, Bernhisel R, Hughes E, Larson K, Rosenthal ET, Singh NA, et al. (April 2021). "Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers". Cancer Prevention Research. 14 (4): 433–440. doi:10.1158/1940-6207.CAPR-20-0448. PMC 8026745. PMID 33509806.
Canman CE, Lim DS (December 1998). "The role of ATM in DNA damage responses and cancer". Oncogene. 17 (25): 3301–8. doi:10.1038/sj.onc.1202577. PMID 9916992.
Kurz EU, Lees-Miller SP (2004). "DNA damage-induced activation of ATM and ATM-dependent signaling pathways". DNA Repair. 3 (8–9): 889–900. doi:10.1016/j.dnarep.2004.03.029. PMID 15279774.
Cremona CA, Behrens A (June 2014). "ATM signalling and cancer". Oncogene. 33 (26): 3351–60. doi:10.1038/onc.2013.275. PMID 23851492.
Friedenson B (August 2007). "The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers". BMC Cancer. 7: 152. doi:10.1186/1471-2407-7-152. PMC 1959234. PMID 17683622.
- "The BRCA1/2 pathway prevents leukemias and lymphomas". Dnatube.
- Armstrong SA, Schultz CW, Azimi-Sadjadi A, Brody JR, Pishvaian MJ (November 2019). "ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications". Molecular Cancer Therapeutics. 18 (11): 1899–1908. doi:10.1158/1535-7163.MCT-19-0208. PMC 6830515. PMID 31676541.
- Dunlop CR, Wallez Y, Johnson TI, Bernaldo de Quirós Fernández S, Durant ST, Cadogan EB, et al. (August 2020). "Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models". British Journal of Cancer. 123 (9): 1424–1436. doi:10.1038/s41416-020-1016-2. PMC 7591912. PMID 32741974. S2CID 220931196.
- Kwok M, Davies N, Agathanggelou A, Smith E, Oldreive C, Petermann E, et al. (February 2016). "ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells". Blood. 127 (5): 582–95. doi:10.1182/blood-2015-05-644872. PMID 26563132.
- Min A, Im SA, Jang H, Kim S, Lee M, Kim DK, et al. (April 2017). "AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells". Molecular Cancer Therapeutics. 16 (4): 566–577. doi:10.1158/1535-7163.MCT-16-0378. PMID 28138034. S2CID 34149115.
- Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ (December 2015). "The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo". Oncotarget. 6 (42): 44289–305. doi:10.18632/oncotarget.6247. PMC 4792557. PMID 26517239.
- Mehdipour P, Karami F, Javan F, Mehrazin M (August 2015). "Linking ATM Promoter Methylation to Cell Cycle Protein Expression in Brain Tumor Patients: Cellular Molecular Triangle Correlation in ATM Territory". Molecular Neurobiology. 52 (1): 293–302. doi:10.1007/s12035-014-8864-9. PMID 25159481. S2CID 35412479.
- Delmonico L, dos Santos Moreira A, Franco MF, Esteves EB, Scherrer L, Gallo CV, et al. (October 2015). "CDKN2A (p14(ARF)/p16(INK4a)) and ATM promoter methylation in patients with impalpable breast lesions". Human Pathology. 46 (10): 1540–7. doi:10.1016/j.humpath.2015.06.016. PMID 26255234.
- Vo QN, Kim WJ, Cvitanovic L, Boudreau DA, Ginzinger DG, Brown KD (December 2004). "The ATM gene is a target for epigenetic silencing in locally advanced breast cancer". Oncogene. 23 (58): 9432–7. doi:10.1038/sj.onc.1208092. PMID 15516988.
- Safar AM, Spencer H, Su X, Coffey M, Cooney CA, Ratnasinghe LD, et al. (June 2005). "Methylation profiling of archived non-small cell lung cancer: a promising prognostic system". Clinical Cancer Research. 11 (12): 4400–5. doi:10.1158/1078-0432.CCR-04-2378. PMID 15958624.
- Bolt J, Vo QN, Kim WJ, McWhorter AJ, Thomson J, Hagensee ME, et al. (November 2005). "The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms". Oral Oncology. 41 (10): 1013–20. doi:10.1016/j.oraloncology.2005.06.003. PMID 16139561.
- Kastan MB (April 2008). "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture". Molecular Cancer Research. 6 (4): 517–24. doi:10.1158/1541-7786.MCR-08-0020. PMID 18403632.
- Harper JW, Elledge SJ (December 2007). "The DNA damage response: ten years after". Molecular Cell. 28 (5): 739–45. doi:10.1016/j.molcel.2007.11.015. PMID 18082599.
- O'Hagan HM, Mohammad HP, Baylin SB (August 2008). "Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island". PLOS Genetics. 4 (8): e1000155. doi:10.1371/journal.pgen.1000155. PMC 2491723. PMID 18704159.
- Cuozzo C, Porcellini A, Angrisano T, Morano A, Lee B, Di Pardo A, et al. (July 2007). "DNA damage, homology-directed repair, and DNA methylation". PLOS Genetics. 3 (7): e110. doi:10.1371/journal.pgen.0030110. PMC 1913100. PMID 17616978.
- Hamer G, Kal HB, Westphal CH, Ashley T, de Rooij DG (April 2004). "Ataxia telangiectasia mutated expression and activation in the testis". Biology of Reproduction. 70 (4): 1206–12. doi:10.1095/biolreprod.103.024950. PMID 14681204.
- Galetzka D, Weis E, Kohlschmidt N, Bitz O, Stein R, Haaf T (April 2007). "Expression of somatic DNA repair genes in human testes". Journal of Cellular Biochemistry. 100 (5): 1232–9. doi:10.1002/jcb.21113. PMID 17177185. S2CID 23743474.
- Barlow C, Liyanage M, Moens PB, Tarsounas M, Nagashima K, Brown K, et al. (October 1998). "Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I". Development. 125 (20): 4007–17. doi:10.1242/dev.125.20.4007. PMID 9735362.
- Titus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K, et al. (February 2013). "Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans". Science Translational Medicine. 5 (172): 172ra21. doi:10.1126/scitranslmed.3004925. PMC 5130338. PMID 23408054.
- Blasina A, Price BD, Turenne GA, McGowan CH (October 1999). "Caffeine inhibits the checkpoint kinase ATM". Current Biology. 9 (19): 1135–1138. Bibcode:1999CBio....9.1135B. doi:10.1016/s0960-9822(99)80486-2. PMID 10531013.
- Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, et al. (July 2008). "Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity". Molecular Cancer Therapeutics. 7 (7): 1851–1863. doi:10.1158/1535-7163.MCT-08-0017. PMID 18606717.
- Toledo LI, Murga M, Zur R, Soria R, Rodriguez A, Martinez S, et al. (June 2011). "A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations". Nature Structural & Molecular Biology. 18 (6): 721–727. doi:10.1038/nsmb.2076. PMC 4869831. PMID 21552262.
- Pike KG, Barlaam B, Cadogan E, Campbell A, Chen Y, Colclough N, et al. (May 2018). "The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)". Journal of Medicinal Chemistry. 61 (9): 3823–3841. doi:10.1021/acs.jmedchem.7b01896. PMID 29683659.
- Zimmermann A, Zenke FT, Chiu LY, Dahmen H, Pehl U, Fuchss T, et al. (June 2022). "A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies". Molecular Cancer Therapeutics. 21 (6): 859–870. doi:10.1158/1535-7163.MCT-21-0934. PMC 9381122. PMID 35405736.
- Dimitrov T, Anli C, Moschopoulou AA, Kronenberger T, Kudolo M, Geibel C, et al. (May 2022). "Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity". European Journal of Medicinal Chemistry. 235: 114234. doi:10.1016/j.ejmech.2022.114234. PMID 35325634. S2CID 247356817.
- Chen G, Yuan SS, Liu W, Xu Y, Trujillo K, Song B, et al. (April 1999). "Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl". The Journal of Biological Chemistry. 274 (18): 12748–52. doi:10.1074/jbc.274.18.12748. PMID 10212258.
- Kishi S, Zhou XZ, Ziv Y, Khoo C, Hill DE, Shiloh Y, et al. (August 2001). "Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks". The Journal of Biological Chemistry. 276 (31): 29282–91. doi:10.1074/jbc.M011534200. PMID 11375976.
- Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, et al. (May 1997). "Interaction between ATM protein and c-Abl in response to DNA damage". Nature. 387 (6632): 520–3. Bibcode:1997Natur.387R.520S. doi:10.1038/387520a0. PMID 9168117. S2CID 4334242.
- Kim ST, Lim DS, Canman CE, Kastan MB (December 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". The Journal of Biological Chemistry. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
- Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (April 2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures". Genes & Development. 14 (8): 927–39. doi:10.1101/gad.14.8.927. PMC 316544. PMID 10783165.
- Cortez D, Wang Y, Qin J, Elledge SJ (November 1999). "Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks". Science. 286 (5442): 1162–6. doi:10.1126/science.286.5442.1162. PMID 10550055.
- Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, et al. (December 2000). "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress". Genes & Development. 14 (23): 2989–3002. doi:10.1101/gad.851000. PMC 317107. PMID 11114888.
- Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK (May 2001). "Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies" (PDF). The Journal of Biological Chemistry. 276 (20): 17276–80. doi:10.1074/jbc.M011681200. PMID 11278964. S2CID 43554268.
- Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, et al. (August 2002). "Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM". The Journal of Biological Chemistry. 277 (34): 30515–23. doi:10.1074/jbc.M203801200. PMID 12034743.
- Suzuki K, Kodama S, Watanabe M (September 1999). "Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation". The Journal of Biological Chemistry. 274 (36): 25571–5. doi:10.1074/jbc.274.36.25571. PMID 10464290.
- Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, et al. (May 2002). "Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways". Cell. 109 (4): 459–72. doi:10.1016/s0092-8674(02)00747-x. PMID 12086603. S2CID 16580666.
- Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/s0014-4827(03)00261-1. PMID 14499622.
- Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, et al. (January 2005). "Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression". Molecular and Cellular Biology. 25 (2): 661–70. doi:10.1128/MCB.25.2.661-670.2005. PMC 543410. PMID 15632067.
- Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, et al. (July 2004). "BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage". The Journal of Biological Chemistry. 279 (30): 31251–8. doi:10.1074/jbc.M405372200. PMID 15159397.
- Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, et al. (December 1998). "ATM associates with and phosphorylates p53: mapping the region of interaction". Nature Genetics. 20 (4): 398–400. doi:10.1038/3882. PMID 9843217. S2CID 23994762.
- Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, et al. (June 2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses". Nature. 411 (6840): 969–74. Bibcode:2001Natur.411..969B. doi:10.1038/35082110. PMID 11418864. S2CID 4429058.
- Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, et al. (July 2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature. 406 (6792): 210–5. Bibcode:2000Natur.406..210L. doi:10.1038/35018134. PMID 10910365. S2CID 3266654.
- Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (April 2005). "Rheb binds and regulates the mTOR kinase". Current Biology. 15 (8): 702–13. Bibcode:2005CBio...15..702L. doi:10.1016/j.cub.2005.02.053. PMID 15854902. S2CID 3078706.
- Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, et al. (November 2008). "ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage". Proceedings of the National Academy of Sciences of the United States of America. 105 (47): 18519–24. Bibcode:2008PNAS..10518519C. doi:10.1073/pnas.0803313105. PMC 2587585. PMID 19015526.
- Kim ST, Xu B, Kastan MB (March 2002). "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage". Genes & Development. 16 (5): 560–70. doi:10.1101/gad.970602. PMC 155347. PMID 11877376.
- Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, et al. (December 2002). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1". Nature Cell Biology. 4 (12): 993–7. doi:10.1038/ncb884. PMID 12447390. S2CID 12380387.
- Ward IM, Minn K, Jorda KG, Chen J (May 2003). "Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX". The Journal of Biological Chemistry. 278 (22): 19579–82. doi:10.1074/jbc.C300117200. PMID 12697768.
- Oikemus SR, McGinnis N, Queiroz-Machado J, Tukachinsky H, Takada S, Sunkel CE, et al. (August 2004). "Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect". Genes & Development. 18 (15): 1850–61. doi:10.1101/gad.1202504. PMC 517405. PMID 15256487.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000149311 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034218 – Ensembl, May 2017

harvard.edu

ui.adsabs.harvard.edu

Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. (June 1995). "A single ataxia telangiectasia gene with a product similar to PI-3 kinase". Science. 268 (5218): 1749–53. Bibcode:1995Sci...268.1749S. doi:10.1126/science.7792600. PMID 7792600.
Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. (September 1998). "Enhanced phosphorylation of p53 by ATM in response to DNA damage". Science. 281 (5383): 1674–7. Bibcode:1998Sci...281.1674B. doi:10.1126/science.281.5383.1674. PMID 9733514.
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. (September 1998). "Activation of the ATM kinase by ionizing radiation and phosphorylation of p53". Science. 281 (5383): 1677–9. Bibcode:1998Sci...281.1677C. doi:10.1126/science.281.5383.1677. PMID 9733515.
Bakkenist CJ, Kastan MB (January 2003). "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation". Nature. 421 (6922): 499–506. Bibcode:2003Natur.421..499B. doi:10.1038/nature01368. PMID 12556884. S2CID 4403303.
Blasina A, Price BD, Turenne GA, McGowan CH (October 1999). "Caffeine inhibits the checkpoint kinase ATM". Current Biology. 9 (19): 1135–1138. Bibcode:1999CBio....9.1135B. doi:10.1016/s0960-9822(99)80486-2. PMID 10531013.
Shafman T, Khanna KK, Kedar P, Spring K, Kozlov S, Yen T, et al. (May 1997). "Interaction between ATM protein and c-Abl in response to DNA damage". Nature. 387 (6632): 520–3. Bibcode:1997Natur.387R.520S. doi:10.1038/387520a0. PMID 9168117. S2CID 4334242.
Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, et al. (June 2001). "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses". Nature. 411 (6840): 969–74. Bibcode:2001Natur.411..969B. doi:10.1038/35082110. PMID 11418864. S2CID 4429058.
Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, et al. (July 2000). "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response". Nature. 406 (6792): 210–5. Bibcode:2000Natur.406..210L. doi:10.1038/35018134. PMID 10910365. S2CID 3266654.
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J (April 2005). "Rheb binds and regulates the mTOR kinase". Current Biology. 15 (8): 702–13. Bibcode:2005CBio...15..702L. doi:10.1016/j.cub.2005.02.053. PMID 15854902. S2CID 3078706.
Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, et al. (November 2008). "ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage". Proceedings of the National Academy of Sciences of the United States of America. 105 (47): 18519–24. Bibcode:2008PNAS..10518519C. doi:10.1073/pnas.0803313105. PMC 2587585. PMID 19015526.

nature.com

Lee JH, Paull TT (December 2021). "Cellular functions of the protein kinase ATM and their relevance to human disease". Nature Reviews Molecular Cell Biology. 22 (12): 796–814. doi:10.1038/s41580-021-00394-2. ISSN 1471-0080. PMID 34429537. S2CID 237294441.
Stakyte K, Rotheneder M, Lammens K, Bartho JD, Grädler U, Fuchß T, et al. (October 2021). "Molecular basis of human ATM kinase inhibition". Nature Structural & Molecular Biology. 28 (10): 789–798. doi:10.1038/s41594-021-00654-x. ISSN 1545-9985. PMID 34556870. S2CID 237615473.

nih.gov

pubmed.ncbi.nlm.nih.gov

Lee JH, Paull TT (December 2021). "Cellular functions of the protein kinase ATM and their relevance to human disease". Nature Reviews Molecular Cell Biology. 22 (12): 796–814. doi:10.1038/s41580-021-00394-2. ISSN 1471-0080. PMID 34429537. S2CID 237294441.
Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, et al. (June 1995). "A single ataxia telangiectasia gene with a product similar to PI-3 kinase". Science. 268 (5218): 1749–53. Bibcode:1995Sci...268.1749S. doi:10.1126/science.7792600. PMID 7792600.
Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. (September 1998). "Enhanced phosphorylation of p53 by ATM in response to DNA damage". Science. 281 (5383): 1674–7. Bibcode:1998Sci...281.1674B. doi:10.1126/science.281.5383.1674. PMID 9733514.
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. (September 1998). "Activation of the ATM kinase by ionizing radiation and phosphorylation of p53". Science. 281 (5383): 1677–9. Bibcode:1998Sci...281.1677C. doi:10.1126/science.281.5383.1677. PMID 9733515.
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ncbi.nlm.nih.gov
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- Hall MJ, Bernhisel R, Hughes E, Larson K, Rosenthal ET, Singh NA, et al. (April 2021). "Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers". Cancer Prevention Research. 14 (4): 433–440. doi:10.1158/1940-6207.CAPR-20-0448. PMC 8026745. PMID 33509806.
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  - "The BRCA1/2 pathway prevents leukemias and lymphomas". Dnatube.
  - Armstrong SA, Schultz CW, Azimi-Sadjadi A, Brody JR, Pishvaian MJ (November 2019). "ATM Dysfunction in Pancreatic Adenocarcinoma and Associated Therapeutic Implications". Molecular Cancer Therapeutics. 18 (11): 1899–1908. doi:10.1158/1535-7163.MCT-19-0208. PMC 6830515. PMID 31676541.
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  - O'Hagan HM, Mohammad HP, Baylin SB (August 2008). "Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island". PLOS Genetics. 4 (8): e1000155. doi:10.1371/journal.pgen.1000155. PMC 2491723. PMID 18704159.
  - Cuozzo C, Porcellini A, Angrisano T, Morano A, Lee B, Di Pardo A, et al. (July 2007). "DNA damage, homology-directed repair, and DNA methylation". PLOS Genetics. 3 (7): e110. doi:10.1371/journal.pgen.0030110. PMC 1913100. PMID 17616978.
  - Titus S, Li F, Stobezki R, Akula K, Unsal E, Jeong K, et al. (February 2013). "Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans". Science Translational Medicine. 5 (172): 172ra21. doi:10.1126/scitranslmed.3004925. PMC 5130338. PMID 23408054.
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  - Zimmermann A, Zenke FT, Chiu LY, Dahmen H, Pehl U, Fuchss T, et al. (June 2022). "A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies". Molecular Cancer Therapeutics. 21 (6): 859–870. doi:10.1158/1535-7163.MCT-21-0934. PMC 9381122. PMID 35405736.
  - Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J (April 2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures". Genes & Development. 14 (8): 927–39. doi:10.1101/gad.14.8.927. PMC 316544. PMID 10783165.
  - Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, et al. (December 2000). "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress". Genes & Development. 14 (23): 2989–3002. doi:10.1101/gad.851000. PMC 317107. PMID 11114888.
  - Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, et al. (January 2005). "Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression". Molecular and Cellular Biology. 25 (2): 661–70. doi:10.1128/MCB.25.2.661-670.2005. PMC 543410. PMID 15632067.
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  - Kim ST, Xu B, Kastan MB (March 2002). "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage". Genes & Development. 16 (5): 560–70. doi:10.1101/gad.970602. PMC 155347. PMID 11877376.
  - Oikemus SR, McGinnis N, Queiroz-Machado J, Tukachinsky H, Takada S, Sunkel CE, et al. (August 2004). "Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect". Genes & Development. 18 (15): 1850–61. doi:10.1101/gad.1202504. PMC 517405. PMID 15256487.

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uniprot.org

"Serine-protein kinase ATM - Homo sapiens (Human)".

uq.edu.au

espace.library.uq.edu.au

Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK (May 2001). "Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies" (PDF). The Journal of Biological Chemistry. 276 (20): 17276–80. doi:10.1074/jbc.M011681200. PMID 11278964. S2CID 43554268.

worldcat.org

Lee JH, Paull TT (December 2021). "Cellular functions of the protein kinase ATM and their relevance to human disease". Nature Reviews Molecular Cell Biology. 22 (12): 796–814. doi:10.1038/s41580-021-00394-2. ISSN 1471-0080. PMID 34429537. S2CID 237294441.
Stakyte K, Rotheneder M, Lammens K, Bartho JD, Grädler U, Fuchß T, et al. (October 2021). "Molecular basis of human ATM kinase inhibition". Nature Structural & Molecular Biology. 28 (10): 789–798. doi:10.1038/s41594-021-00654-x. ISSN 1545-9985. PMID 34556870. S2CID 237615473.