Anaplastic lymphoma kinase (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Anaplastic lymphoma kinase" in English language version.

refsWebsite

Global rank English rank

105nih.gov

4^th place

69doi.org

2^nd place

14semanticscholar.org

11^th place

8^th place

12harvard.edu

18^th place

17^th place

2ensembl.org

1,626^th place

1,007^th place

2fda.gov

447^th place

338^th place

1roche.com

low place

doi.org

Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, et al. (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–1284. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.
Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, et al. (January 1997). "Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system". Oncogene. 14 (4): 439–449. doi:10.1038/sj.onc.1200849. PMID 9053841.
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, et al. (May 1997). "ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)". Oncogene. 14 (18): 2175–2188. doi:10.1038/sj.onc.1201062. PMID 9174053.
Lorén CE, Scully A, Grabbe C, Edeen PT, Thomas J, McKeown M, et al. (June 2001). "Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo". Genes to Cells. 6 (6): 531–544. doi:10.1046/j.1365-2443.2001.00440.x. PMC 1975818. PMID 11442633.
Liao EH, Hung W, Abrams B, Zhen M (July 2004). "An SCF-like ubiquitin ligase complex that controls presynaptic differentiation". Nature. 430 (6997): 345–350. Bibcode:2004Natur.430..345L. doi:10.1038/nature02647. PMID 15208641. S2CID 4428538.
Yao S, Cheng M, Zhang Q, Wasik M, Kelsh R, Winkler C (May 2013). "Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish". PLOS ONE. 8 (5): e63757. Bibcode:2013PLoSO...863757Y. doi:10.1371/journal.pone.0063757. PMC 3648509. PMID 23667670.
Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, et al. (September 2015). "FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase". eLife. 4: e09811. doi:10.7554/eLife.09811. PMC 4658194. PMID 26418745.
Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, et al. (December 2015). "Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions". Proceedings of the National Academy of Sciences of the United States of America. 112 (52): 15862–15867. Bibcode:2015PNAS..11215862R. doi:10.1073/pnas.1520099112. PMC 4702955. PMID 26630010.
Zhang H, Pao LI, Zhou A, Brace AD, Halenbeck R, Hsu AW, et al. (November 2014). "Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome". Proceedings of the National Academy of Sciences of the United States of America. 111 (44): 15741–15745. Bibcode:2014PNAS..11115741Z. doi:10.1073/pnas.1412009111. PMC 4226105. PMID 25331893.
Englund C, Lorén CE, Grabbe C, Varshney GK, Deleuil F, Hallberg B, et al. (October 2003). "Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion". Nature. 425 (6957): 512–516. Bibcode:2003Natur.425..512E. doi:10.1038/nature01950. PMID 14523447. S2CID 4425423.
Lee HH, Norris A, Weiss JB, Frasch M (October 2003). "Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers". Nature. 425 (6957): 507–512. Bibcode:2003Natur.425..507L. doi:10.1038/nature01916. PMID 14523446. S2CID 4424062.
Reiner DJ, Ailion M, Thomas JH, Meyer BJ (August 2008). "C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling". Current Biology. 18 (15): 1101–1109. Bibcode:2008CBio...18.1101R. doi:10.1016/j.cub.2008.06.060. PMC 3489285. PMID 18674914.
Hallberg B, Palmer RH (October 2013). "Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology". Nature Reviews. Cancer. 13 (10): 685–700. doi:10.1038/nrc3580. PMID 24060861. S2CID 21345361.
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, et al. (April 1996). "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)". Proceedings of the National Academy of Sciences of the United States of America. 93 (9): 4181–4186. Bibcode:1996PNAS...93.4181F. doi:10.1073/pnas.93.9.4181. PMC 39508. PMID 8633037.
Motegi A, Fujimoto J, Kotani M, Sakuraba H, Yamamoto T (July 2004). "ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth". Journal of Cell Science. 117 (Pt 15): 3319–3329. doi:10.1242/jcs.01183. PMID 15226403.
Degoutin J, Vigny M, Gouzi JY (February 2007). "ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation". FEBS Letters. 581 (4): 727–734. doi:10.1016/j.febslet.2007.01.039. PMID 17274988. S2CID 40978851.
Cussac D, Greenland C, Roche S, Bai RY, Duyster J, Morris SW, et al. (February 2004). "Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity". Blood. 103 (4): 1464–1471. doi:10.1182/blood-2003-04-1038. PMID 14563642.
Voena C, Conte C, Ambrogio C, Boeri Erba E, Boccalatte F, Mohammed S, et al. (May 2007). "The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration". Cancer Research. 67 (9): 4278–4286. doi:10.1158/0008-5472.CAN-06-4350. PMID 17483340.
Bai RY, Dieter P, Peschel C, Morris SW, Duyster J (December 1998). "Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity". Molecular and Cellular Biology. 18 (12): 6951–6961. doi:10.1128/mcb.18.12.6951. PMC 109278. PMID 9819383.
Bai RY, Ouyang T, Miething C, Morris SW, Peschel C, Duyster J (December 2000). "Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway". Blood. 96 (13): 4319–4327. doi:10.1182/blood.V96.13.4319. PMID 11110708.
Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, et al. (September 2011). "The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning". PLOS Genetics. 7 (9): e1002281. doi:10.1371/journal.pgen.1002281. PMC 3174217. PMID 21949657.
Gu TL, Tothova Z, Scheijen B, Griffin JD, Gilliland DG, Sternberg DW (June 2004). "NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a". Blood. 103 (12): 4622–4629. doi:10.1182/blood-2003-03-0820. PMID 14962911.
Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R, et al. (January 2005). "Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma". Blood. 105 (2): 827–829. doi:10.1182/blood-2004-06-2125. PMC 1382060. PMID 15374880.
Ouyang T, Bai RY, Bassermann F, von Klitzing C, Klumpen S, Miething C, et al. (August 2003). "Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA)". The Journal of Biological Chemistry. 278 (32): 30028–30036. doi:10.1074/jbc.M300883200. PMID 12748172.
Bassermann F, von Klitzing C, Münch S, Bai RY, Kawaguchi H, Morris SW, et al. (July 2005). "NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry". Cell. 122 (1): 45–57. doi:10.1016/j.cell.2005.04.034. PMID 16009132. S2CID 16122567.
Colomba A, Courilleau D, Ramel D, Billadeau DD, Espinos E, Delsol G, et al. (April 2008). "Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas". Oncogene. 27 (19): 2728–2736. doi:10.1038/sj.onc.1210921. PMID 17998938.
Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, et al. (November 2008). "The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation". Cancer Research. 68 (21): 8899–8907. doi:10.1158/0008-5472.CAN-08-2568. PMC 2596920. PMID 18974134.
Ambrogio C, Voena C, Manazza AD, Piva R, Riera L, Barberis L, et al. (December 2005). "p130Cas mediates the transforming properties of the anaplastic lymphoma kinase". Blood. 106 (12): 3907–3916. doi:10.1182/blood-2005-03-1204. PMC 1895100. PMID 16105984.
Hegazy SA, Wang P, Anand M, Ingham RJ, Gelebart P, Lai R (June 2010). "The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions". The Journal of Biological Chemistry. 285 (26): 19813–19820. doi:10.1074/jbc.M110.121988. PMC 2888392. PMID 20424160.
Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, et al. (September 2011). "The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness". The Journal of Biological Chemistry. 286 (37): 32105–32114. doi:10.1074/jbc.M111.227512. PMC 3173219. PMID 21737449.
Palmer RH, Vernersson E, Grabbe C, Hallberg B (May 2009). "Anaplastic lymphoma kinase: signalling in development and disease". The Biochemical Journal. 420 (3): 345–361. doi:10.1042/BJ20090387. PMC 2708929. PMID 19459784.
Vernersson E, Khoo NK, Henriksson ML, Roos G, Palmer RH, Hallberg B (June 2006). "Characterization of the expression of the ALK receptor tyrosine kinase in mice". Gene Expression Patterns. 6 (5): 448–461. doi:10.1016/j.modgep.2005.11.006. PMID 16458083.
Souttou B, Carvalho NB, Raulais D, Vigny M (March 2001). "Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 276 (12): 9526–9531. doi:10.1074/jbc.M007333200. PMID 11121404.
Moog-Lutz C, Degoutin J, Gouzi JY, Frobert Y, Brunet-de Carvalho N, Bureau J, et al. (July 2005). "Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin". The Journal of Biological Chemistry. 280 (28): 26039–26048. doi:10.1074/jbc.M501972200. PMID 15886198.
Gouzi JY, Moog-Lutz C, Vigny M, Brunet-de Carvalho N (December 2005). "Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells". Journal of Cell Science. 118 (Pt 24): 5811–5823. doi:10.1242/jcs.02695. PMID 16317043.
Stute C, Schimmelpfeng K, Renkawitz-Pohl R, Palmer RH, Holz A (February 2004). "Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling". Development. 131 (4): 743–754. doi:10.1242/dev.00972. PMID 14757637.
Bilsland JG, Wheeldon A, Mead A, Znamenskiy P, Almond S, Waters KA, et al. (February 2008). "Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications". Neuropsychopharmacology. 33 (3): 685–700. doi:10.1038/sj.npp.1301446. PMID 17487225.
Weiss JB, Xue C, Benice T, Xue L, Morris SW, Raber J (January 2012). "Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis". Pharmacology, Biochemistry, and Behavior. 100 (3): 566–574. doi:10.1016/j.pbb.2011.10.024. PMID 22079349. S2CID 2386055.
Witek B, El Wakil A, Nord C, Ahlgren U, Eriksson M, Vernersson-Lindahl E, et al. (May 2015). "Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism". PLOS ONE. 10 (5): e0123542. Bibcode:2015PLoSO..1023542W. doi:10.1371/journal.pone.0123542. PMC 4425494. PMID 25955180.
Bazigou E, Apitz H, Johansson J, Lorén CE, Hirst EM, Chen PL, et al. (March 2007). "Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila". Cell. 128 (5): 961–975. doi:10.1016/j.cell.2007.02.024. PMID 17350579. S2CID 10341647.
Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP (August 2011). "Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila". Cell. 146 (3): 435–447. doi:10.1016/j.cell.2011.06.040. PMID 21816278. S2CID 4287148.
Rohrbough J, Broadie K (October 2010). "Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap". Development. 137 (20): 3523–3533. doi:10.1242/dev.047878. PMC 2947762. PMID 20876658.
Rohrbough J, Kent KS, Broadie K, Weiss JB (March 2013). "Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture". Developmental Neurobiology. 73 (3): 189–208. doi:10.1002/dneu.22056. PMC 3565053. PMID 22949158.
Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, et al. (Jul 2011). "An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol". PLOS ONE. 6 (7): e22636. Bibcode:2011PLoSO...622636L. doi:10.1371/journal.pone.0022636. PMC 3142173. PMID 21799923.
Schweitzer P, Cates-Gatto C, Varodayan FP, Nadav T, Roberto M, Lasek AW, et al. (August 2016). "Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice". Neuropharmacology. 107: 1–8. doi:10.1016/j.neuropharm.2016.03.003. PMC 4912883. PMID 26946429.
Dutton JW, Chen H, You C, Brodie MS, Lasek AW (May 2017). "Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area". Addiction Biology. 22 (3): 665–678. doi:10.1111/adb.12358. PMC 4940304. PMID 26752591.
Mangieri RA, Maier EY, Buske TR, Lasek AW, Morrisett RA (Aug 2017). "Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell". Frontiers in Pharmacology. 8: 533. doi:10.3389/fphar.2017.00533. PMC 5559467. PMID 28860990.
Bai L, Sehgal A (November 2015). "Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep". PLOS Genetics. 11 (11): e1005611. doi:10.1371/journal.pgen.1005611. PMC 4633181. PMID 26536237.
Gouzi JY, Bouraimi M, Roussou IG, Moressis A, Skoulakis EM (August 2018). "The Drosophila Receptor Tyrosine Kinase Alk Constrains Long-Term Memory Formation". The Journal of Neuroscience. 38 (35): 7701–7712. doi:10.1523/JNEUROSCI.0784-18.2018. PMC 6705970. PMID 30030398.
Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, et al. (May 2020). "The neuronal receptor tyrosine kinase Alk is a target for longevity". Aging Cell. 19 (5): e13137. doi:10.1111/acel.13137. PMC 7253064. PMID 32291952.
Orthofer M, Valsesia A, Mägi R, Wang QP, Kaczanowska J, Kozieradzki I, et al. (June 2020). "Identification of ALK in Thinness". Cell. 181 (6): 1246–1262.e22. doi:10.1016/j.cell.2020.04.034. PMID 32442405. S2CID 218762956.
Mologni L (July 2012). "Inhibitors of the anaplastic lymphoma kinase". Expert Opinion on Investigational Drugs. 21 (7): 985–994. doi:10.1517/13543784.2012.690031. PMID 22612599. S2CID 24564015.
Patcas A, Chis AF, Militaru CF, Bordea IR, Rajnoveanu R, Coza OF, et al. (February 2022). "An insight into lung cancer: a comprehensive review exploring ALK TKI and mechanisms of resistance". Bosnian Journal of Basic Medical Sciences. 22 (1): 1–13. doi:10.17305/bjbms.2021.5859. PMC 8860314. PMID 34082691.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. (February 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma". Journal of Thoracic Oncology. 6 (2): 244–285. doi:10.1097/JTO.0b013e318206a221. PMC 4513953. PMID 21252716.
Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, et al. (October 2008). "Identification of ALK as a major familial neuroblastoma predisposition gene". Nature. 455 (7215): 930–935. Bibcode:2008Natur.455..930M. doi:10.1038/nature07261. PMC 2672043. PMID 18724359.
Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, et al. (August 2002). "Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor". Genes, Chromosomes & Cancer. 34 (4): 354–362. doi:10.1002/gcc.10033. PMID 12112524. S2CID 22808049.
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, et al. (August 2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". The American Journal of Pathology. 157 (2): 377–384. doi:10.1016/S0002-9440(10)64550-6. PMC 1850130. PMID 10934142.
Sukov WR, Hodge JC, Lohse CM, Akre MK, Leibovich BC, Thompson RH, et al. (November 2012). "ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients". Modern Pathology. 25 (11): 1516–1525. doi:10.1038/modpathol.2012.107. PMID 22743654.
Sugawara E, Togashi Y, Kuroda N, Sakata S, Hatano S, Asaka R, et al. (September 2012). "Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method". Cancer. 118 (18): 4427–4436. doi:10.1002/cncr.27391. PMID 22252991. S2CID 9387860.
Debelenko LV, Raimondi SC, Daw N, Shivakumar BR, Huang D, Nelson M, et al. (March 2011). "Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum". Modern Pathology. 24 (3): 430–442. doi:10.1038/modpathol.2010.213. PMID 21076462.
Mariño-Enríquez A, Ou WB, Weldon CB, Fletcher JA, Pérez-Atayde AR (March 2011). "ALK rearrangement in sickle cell trait-associated renal medullary carcinoma". Genes, Chromosomes & Cancer. 50 (3): 146–153. doi:10.1002/gcc.20839. PMID 21213368. S2CID 39004672.
Jazii FR, Najafi Z, Malekzadeh R, Conrads TP, Ziaee AA, Abnet C, et al. (November 2006). "Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer". World Journal of Gastroenterology. 12 (44): 7104–7112. doi:10.3748/wjg.v12.i44.7104. PMC 4087770. PMID 17131471.
Lin E, Li L, Guan Y, Soriano R, Rivers CS, Mohan S, et al. (September 2009). "Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers". Molecular Cancer Research. 7 (9): 1466–1476. doi:10.1158/1541-7786.MCR-08-0522. PMID 19737969.
Tuma RS (January 2012). "ALK gene amplified in most inflammatory breast cancers". Journal of the National Cancer Institute. 104 (2): 87–88. doi:10.1093/jnci/djr553. PMID 22215853.
Powers C, Aigner A, Stoica GE, McDonnell K, Wellstein A (April 2002). "Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth". The Journal of Biological Chemistry. 277 (16): 14153–14158. doi:10.1074/jbc.M112354200. PMID 11809760.
Stoica GE, Kuo A, Aigner A, Sunitha I, Souttou B, Malerczyk C, et al. (May 2001). "Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin". The Journal of Biological Chemistry. 276 (20): 16772–16779. doi:10.1074/jbc.M010660200. PMID 11278720.
Murugan AK, Xing M (July 2011). "Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene". Cancer Research. 71 (13): 4403–4411. doi:10.1158/0008-5472.CAN-10-4041. PMC 3129369. PMID 21596819.
Gambacorti-Passerini C, Messa C, Pogliani EM (February 2011). "Crizotinib in anaplastic large-cell lymphoma". The New England Journal of Medicine. 364 (8): 775–776. doi:10.1056/NEJMc1013224. PMID 21345110.
Gambacorti Passerini C, Farina F, Stasia A, Redaelli S, Ceccon M, Mologni L, et al. (February 2014). "Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients". Journal of the National Cancer Institute. 106 (2): djt378. doi:10.1093/jnci/djt378. PMID 24491302.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000171094 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055471 – Ensembl, May 2017

fda.gov

accessdata.fda.gov

"Xalkori Approved for Lung Cancer". FDA.
"ZYKADIA (ceritinib) capsules, for oral use Initial U.S. Approval: 2014" (PDF). United States Food and Drug Administration.

harvard.edu

ui.adsabs.harvard.edu

Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, et al. (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–1284. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.
Liao EH, Hung W, Abrams B, Zhen M (July 2004). "An SCF-like ubiquitin ligase complex that controls presynaptic differentiation". Nature. 430 (6997): 345–350. Bibcode:2004Natur.430..345L. doi:10.1038/nature02647. PMID 15208641. S2CID 4428538.
Yao S, Cheng M, Zhang Q, Wasik M, Kelsh R, Winkler C (May 2013). "Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish". PLOS ONE. 8 (5): e63757. Bibcode:2013PLoSO...863757Y. doi:10.1371/journal.pone.0063757. PMC 3648509. PMID 23667670.
Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, et al. (December 2015). "Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions". Proceedings of the National Academy of Sciences of the United States of America. 112 (52): 15862–15867. Bibcode:2015PNAS..11215862R. doi:10.1073/pnas.1520099112. PMC 4702955. PMID 26630010.
Zhang H, Pao LI, Zhou A, Brace AD, Halenbeck R, Hsu AW, et al. (November 2014). "Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome". Proceedings of the National Academy of Sciences of the United States of America. 111 (44): 15741–15745. Bibcode:2014PNAS..11115741Z. doi:10.1073/pnas.1412009111. PMC 4226105. PMID 25331893.
Englund C, Lorén CE, Grabbe C, Varshney GK, Deleuil F, Hallberg B, et al. (October 2003). "Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion". Nature. 425 (6957): 512–516. Bibcode:2003Natur.425..512E. doi:10.1038/nature01950. PMID 14523447. S2CID 4425423.
Lee HH, Norris A, Weiss JB, Frasch M (October 2003). "Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers". Nature. 425 (6957): 507–512. Bibcode:2003Natur.425..507L. doi:10.1038/nature01916. PMID 14523446. S2CID 4424062.
Reiner DJ, Ailion M, Thomas JH, Meyer BJ (August 2008). "C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling". Current Biology. 18 (15): 1101–1109. Bibcode:2008CBio...18.1101R. doi:10.1016/j.cub.2008.06.060. PMC 3489285. PMID 18674914.
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, et al. (April 1996). "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)". Proceedings of the National Academy of Sciences of the United States of America. 93 (9): 4181–4186. Bibcode:1996PNAS...93.4181F. doi:10.1073/pnas.93.9.4181. PMC 39508. PMID 8633037.
Witek B, El Wakil A, Nord C, Ahlgren U, Eriksson M, Vernersson-Lindahl E, et al. (May 2015). "Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism". PLOS ONE. 10 (5): e0123542. Bibcode:2015PLoSO..1023542W. doi:10.1371/journal.pone.0123542. PMC 4425494. PMID 25955180.
Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, et al. (Jul 2011). "An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol". PLOS ONE. 6 (7): e22636. Bibcode:2011PLoSO...622636L. doi:10.1371/journal.pone.0022636. PMC 3142173. PMID 21799923.
Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, et al. (October 2008). "Identification of ALK as a major familial neuroblastoma predisposition gene". Nature. 455 (7215): 930–935. Bibcode:2008Natur.455..930M. doi:10.1038/nature07261. PMC 2672043. PMID 18724359.

nih.gov

pubmed.ncbi.nlm.nih.gov

Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL, et al. (March 1994). "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma". Science. 263 (5151): 1281–1284. Bibcode:1994Sci...263.1281M. doi:10.1126/science.8122112. PMID 8122112.
Shiota M, Fujimoto J, Semba T, Satoh H, Yamamoto T, Mori S (June 1994). "Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3". Oncogene. 9 (6): 1567–1574. PMID 8183550.
Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, et al. (January 1997). "Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system". Oncogene. 14 (4): 439–449. doi:10.1038/sj.onc.1200849. PMID 9053841.
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, et al. (May 1997). "ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)". Oncogene. 14 (18): 2175–2188. doi:10.1038/sj.onc.1201062. PMID 9174053.
Lorén CE, Scully A, Grabbe C, Edeen PT, Thomas J, McKeown M, et al. (June 2001). "Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo". Genes to Cells. 6 (6): 531–544. doi:10.1046/j.1365-2443.2001.00440.x. PMC 1975818. PMID 11442633.
Liao EH, Hung W, Abrams B, Zhen M (July 2004). "An SCF-like ubiquitin ligase complex that controls presynaptic differentiation". Nature. 430 (6997): 345–350. Bibcode:2004Natur.430..345L. doi:10.1038/nature02647. PMID 15208641. S2CID 4428538.
Yao S, Cheng M, Zhang Q, Wasik M, Kelsh R, Winkler C (May 2013). "Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish". PLOS ONE. 8 (5): e63757. Bibcode:2013PLoSO...863757Y. doi:10.1371/journal.pone.0063757. PMC 3648509. PMID 23667670.
Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, et al. (September 2015). "FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase". eLife. 4: e09811. doi:10.7554/eLife.09811. PMC 4658194. PMID 26418745.
Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, et al. (December 2015). "Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions". Proceedings of the National Academy of Sciences of the United States of America. 112 (52): 15862–15867. Bibcode:2015PNAS..11215862R. doi:10.1073/pnas.1520099112. PMC 4702955. PMID 26630010.
Zhang H, Pao LI, Zhou A, Brace AD, Halenbeck R, Hsu AW, et al. (November 2014). "Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome". Proceedings of the National Academy of Sciences of the United States of America. 111 (44): 15741–15745. Bibcode:2014PNAS..11115741Z. doi:10.1073/pnas.1412009111. PMC 4226105. PMID 25331893.
Englund C, Lorén CE, Grabbe C, Varshney GK, Deleuil F, Hallberg B, et al. (October 2003). "Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion". Nature. 425 (6957): 512–516. Bibcode:2003Natur.425..512E. doi:10.1038/nature01950. PMID 14523447. S2CID 4425423.
Lee HH, Norris A, Weiss JB, Frasch M (October 2003). "Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers". Nature. 425 (6957): 507–512. Bibcode:2003Natur.425..507L. doi:10.1038/nature01916. PMID 14523446. S2CID 4424062.
Reiner DJ, Ailion M, Thomas JH, Meyer BJ (August 2008). "C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling". Current Biology. 18 (15): 1101–1109. Bibcode:2008CBio...18.1101R. doi:10.1016/j.cub.2008.06.060. PMC 3489285. PMID 18674914.
Hallberg B, Palmer RH (October 2013). "Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology". Nature Reviews. Cancer. 13 (10): 685–700. doi:10.1038/nrc3580. PMID 24060861. S2CID 21345361.
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, et al. (April 1996). "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)". Proceedings of the National Academy of Sciences of the United States of America. 93 (9): 4181–4186. Bibcode:1996PNAS...93.4181F. doi:10.1073/pnas.93.9.4181. PMC 39508. PMID 8633037.
Motegi A, Fujimoto J, Kotani M, Sakuraba H, Yamamoto T (July 2004). "ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth". Journal of Cell Science. 117 (Pt 15): 3319–3329. doi:10.1242/jcs.01183. PMID 15226403.
Degoutin J, Vigny M, Gouzi JY (February 2007). "ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation". FEBS Letters. 581 (4): 727–734. doi:10.1016/j.febslet.2007.01.039. PMID 17274988. S2CID 40978851.
Cussac D, Greenland C, Roche S, Bai RY, Duyster J, Morris SW, et al. (February 2004). "Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity". Blood. 103 (4): 1464–1471. doi:10.1182/blood-2003-04-1038. PMID 14563642.
Voena C, Conte C, Ambrogio C, Boeri Erba E, Boccalatte F, Mohammed S, et al. (May 2007). "The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration". Cancer Research. 67 (9): 4278–4286. doi:10.1158/0008-5472.CAN-06-4350. PMID 17483340.
Bai RY, Dieter P, Peschel C, Morris SW, Duyster J (December 1998). "Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity". Molecular and Cellular Biology. 18 (12): 6951–6961. doi:10.1128/mcb.18.12.6951. PMC 109278. PMID 9819383.
Bai RY, Ouyang T, Miething C, Morris SW, Peschel C, Duyster J (December 2000). "Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway". Blood. 96 (13): 4319–4327. doi:10.1182/blood.V96.13.4319. PMID 11110708.
Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, et al. (September 2011). "The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning". PLOS Genetics. 7 (9): e1002281. doi:10.1371/journal.pgen.1002281. PMC 3174217. PMID 21949657.
Gu TL, Tothova Z, Scheijen B, Griffin JD, Gilliland DG, Sternberg DW (June 2004). "NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a". Blood. 103 (12): 4622–4629. doi:10.1182/blood-2003-03-0820. PMID 14962911.
Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R, et al. (January 2005). "Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma". Blood. 105 (2): 827–829. doi:10.1182/blood-2004-06-2125. PMC 1382060. PMID 15374880.
Ouyang T, Bai RY, Bassermann F, von Klitzing C, Klumpen S, Miething C, et al. (August 2003). "Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA)". The Journal of Biological Chemistry. 278 (32): 30028–30036. doi:10.1074/jbc.M300883200. PMID 12748172.
Bassermann F, von Klitzing C, Münch S, Bai RY, Kawaguchi H, Morris SW, et al. (July 2005). "NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry". Cell. 122 (1): 45–57. doi:10.1016/j.cell.2005.04.034. PMID 16009132. S2CID 16122567.
Colomba A, Courilleau D, Ramel D, Billadeau DD, Espinos E, Delsol G, et al. (April 2008). "Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas". Oncogene. 27 (19): 2728–2736. doi:10.1038/sj.onc.1210921. PMID 17998938.
Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, et al. (November 2008). "The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation". Cancer Research. 68 (21): 8899–8907. doi:10.1158/0008-5472.CAN-08-2568. PMC 2596920. PMID 18974134.
Ambrogio C, Voena C, Manazza AD, Piva R, Riera L, Barberis L, et al. (December 2005). "p130Cas mediates the transforming properties of the anaplastic lymphoma kinase". Blood. 106 (12): 3907–3916. doi:10.1182/blood-2005-03-1204. PMC 1895100. PMID 16105984.
Hegazy SA, Wang P, Anand M, Ingham RJ, Gelebart P, Lai R (June 2010). "The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions". The Journal of Biological Chemistry. 285 (26): 19813–19820. doi:10.1074/jbc.M110.121988. PMC 2888392. PMID 20424160.
Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, et al. (September 2011). "The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness". The Journal of Biological Chemistry. 286 (37): 32105–32114. doi:10.1074/jbc.M111.227512. PMC 3173219. PMID 21737449.
Palmer RH, Vernersson E, Grabbe C, Hallberg B (May 2009). "Anaplastic lymphoma kinase: signalling in development and disease". The Biochemical Journal. 420 (3): 345–361. doi:10.1042/BJ20090387. PMC 2708929. PMID 19459784.
Vernersson E, Khoo NK, Henriksson ML, Roos G, Palmer RH, Hallberg B (June 2006). "Characterization of the expression of the ALK receptor tyrosine kinase in mice". Gene Expression Patterns. 6 (5): 448–461. doi:10.1016/j.modgep.2005.11.006. PMID 16458083.
Souttou B, Carvalho NB, Raulais D, Vigny M (March 2001). "Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 276 (12): 9526–9531. doi:10.1074/jbc.M007333200. PMID 11121404.
Moog-Lutz C, Degoutin J, Gouzi JY, Frobert Y, Brunet-de Carvalho N, Bureau J, et al. (July 2005). "Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin". The Journal of Biological Chemistry. 280 (28): 26039–26048. doi:10.1074/jbc.M501972200. PMID 15886198.
Gouzi JY, Moog-Lutz C, Vigny M, Brunet-de Carvalho N (December 2005). "Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells". Journal of Cell Science. 118 (Pt 24): 5811–5823. doi:10.1242/jcs.02695. PMID 16317043.
Stute C, Schimmelpfeng K, Renkawitz-Pohl R, Palmer RH, Holz A (February 2004). "Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling". Development. 131 (4): 743–754. doi:10.1242/dev.00972. PMID 14757637.
Bilsland JG, Wheeldon A, Mead A, Znamenskiy P, Almond S, Waters KA, et al. (February 2008). "Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications". Neuropsychopharmacology. 33 (3): 685–700. doi:10.1038/sj.npp.1301446. PMID 17487225.
Weiss JB, Xue C, Benice T, Xue L, Morris SW, Raber J (January 2012). "Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis". Pharmacology, Biochemistry, and Behavior. 100 (3): 566–574. doi:10.1016/j.pbb.2011.10.024. PMID 22079349. S2CID 2386055.
Witek B, El Wakil A, Nord C, Ahlgren U, Eriksson M, Vernersson-Lindahl E, et al. (May 2015). "Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism". PLOS ONE. 10 (5): e0123542. Bibcode:2015PLoSO..1023542W. doi:10.1371/journal.pone.0123542. PMC 4425494. PMID 25955180.
Bazigou E, Apitz H, Johansson J, Lorén CE, Hirst EM, Chen PL, et al. (March 2007). "Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila". Cell. 128 (5): 961–975. doi:10.1016/j.cell.2007.02.024. PMID 17350579. S2CID 10341647.
Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP (August 2011). "Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila". Cell. 146 (3): 435–447. doi:10.1016/j.cell.2011.06.040. PMID 21816278. S2CID 4287148.
Rohrbough J, Broadie K (October 2010). "Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap". Development. 137 (20): 3523–3533. doi:10.1242/dev.047878. PMC 2947762. PMID 20876658.
Rohrbough J, Kent KS, Broadie K, Weiss JB (March 2013). "Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture". Developmental Neurobiology. 73 (3): 189–208. doi:10.1002/dneu.22056. PMC 3565053. PMID 22949158.
Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, et al. (Jul 2011). "An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol". PLOS ONE. 6 (7): e22636. Bibcode:2011PLoSO...622636L. doi:10.1371/journal.pone.0022636. PMC 3142173. PMID 21799923.
Schweitzer P, Cates-Gatto C, Varodayan FP, Nadav T, Roberto M, Lasek AW, et al. (August 2016). "Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice". Neuropharmacology. 107: 1–8. doi:10.1016/j.neuropharm.2016.03.003. PMC 4912883. PMID 26946429.
Dutton JW, Chen H, You C, Brodie MS, Lasek AW (May 2017). "Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area". Addiction Biology. 22 (3): 665–678. doi:10.1111/adb.12358. PMC 4940304. PMID 26752591.
Mangieri RA, Maier EY, Buske TR, Lasek AW, Morrisett RA (Aug 2017). "Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell". Frontiers in Pharmacology. 8: 533. doi:10.3389/fphar.2017.00533. PMC 5559467. PMID 28860990.
Bai L, Sehgal A (November 2015). "Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep". PLOS Genetics. 11 (11): e1005611. doi:10.1371/journal.pgen.1005611. PMC 4633181. PMID 26536237.
Gouzi JY, Bouraimi M, Roussou IG, Moressis A, Skoulakis EM (August 2018). "The Drosophila Receptor Tyrosine Kinase Alk Constrains Long-Term Memory Formation". The Journal of Neuroscience. 38 (35): 7701–7712. doi:10.1523/JNEUROSCI.0784-18.2018. PMC 6705970. PMID 30030398.
Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, et al. (May 2020). "The neuronal receptor tyrosine kinase Alk is a target for longevity". Aging Cell. 19 (5): e13137. doi:10.1111/acel.13137. PMC 7253064. PMID 32291952.
Orthofer M, Valsesia A, Mägi R, Wang QP, Kaczanowska J, Kozieradzki I, et al. (June 2020). "Identification of ALK in Thinness". Cell. 181 (6): 1246–1262.e22. doi:10.1016/j.cell.2020.04.034. PMID 32442405. S2CID 218762956.
Mologni L (July 2012). "Inhibitors of the anaplastic lymphoma kinase". Expert Opinion on Investigational Drugs. 21 (7): 985–994. doi:10.1517/13543784.2012.690031. PMID 22612599. S2CID 24564015.
Patcas A, Chis AF, Militaru CF, Bordea IR, Rajnoveanu R, Coza OF, et al. (February 2022). "An insight into lung cancer: a comprehensive review exploring ALK TKI and mechanisms of resistance". Bosnian Journal of Basic Medical Sciences. 22 (1): 1–13. doi:10.17305/bjbms.2021.5859. PMC 8860314. PMID 34082691.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. (February 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma". Journal of Thoracic Oncology. 6 (2): 244–285. doi:10.1097/JTO.0b013e318206a221. PMC 4513953. PMID 21252716.
Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, et al. (October 2008). "Identification of ALK as a major familial neuroblastoma predisposition gene". Nature. 455 (7215): 930–935. Bibcode:2008Natur.455..930M. doi:10.1038/nature07261. PMC 2672043. PMID 18724359.
Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, et al. (August 2002). "Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor". Genes, Chromosomes & Cancer. 34 (4): 354–362. doi:10.1002/gcc.10033. PMID 12112524. S2CID 22808049.
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, et al. (August 2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". The American Journal of Pathology. 157 (2): 377–384. doi:10.1016/S0002-9440(10)64550-6. PMC 1850130. PMID 10934142.
Sukov WR, Hodge JC, Lohse CM, Akre MK, Leibovich BC, Thompson RH, et al. (November 2012). "ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients". Modern Pathology. 25 (11): 1516–1525. doi:10.1038/modpathol.2012.107. PMID 22743654.
Sugawara E, Togashi Y, Kuroda N, Sakata S, Hatano S, Asaka R, et al. (September 2012). "Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method". Cancer. 118 (18): 4427–4436. doi:10.1002/cncr.27391. PMID 22252991. S2CID 9387860.
Debelenko LV, Raimondi SC, Daw N, Shivakumar BR, Huang D, Nelson M, et al. (March 2011). "Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum". Modern Pathology. 24 (3): 430–442. doi:10.1038/modpathol.2010.213. PMID 21076462.
Mariño-Enríquez A, Ou WB, Weldon CB, Fletcher JA, Pérez-Atayde AR (March 2011). "ALK rearrangement in sickle cell trait-associated renal medullary carcinoma". Genes, Chromosomes & Cancer. 50 (3): 146–153. doi:10.1002/gcc.20839. PMID 21213368. S2CID 39004672.
Jazii FR, Najafi Z, Malekzadeh R, Conrads TP, Ziaee AA, Abnet C, et al. (November 2006). "Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer". World Journal of Gastroenterology. 12 (44): 7104–7112. doi:10.3748/wjg.v12.i44.7104. PMC 4087770. PMID 17131471.
Yaakup H, Sagap I, Fadilah SA (October 2008). "Primary oesophageal Ki (CD30)-positive ALK+ anaplastic large cell lymphoma of T-cell phenotype". Singapore Medical Journal. 49 (10): e289 – e292. PMID 18946602.
Lin E, Li L, Guan Y, Soriano R, Rivers CS, Mohan S, et al. (September 2009). "Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers". Molecular Cancer Research. 7 (9): 1466–1476. doi:10.1158/1541-7786.MCR-08-0522. PMID 19737969.
Tuma RS (January 2012). "ALK gene amplified in most inflammatory breast cancers". Journal of the National Cancer Institute. 104 (2): 87–88. doi:10.1093/jnci/djr553. PMID 22215853.
Powers C, Aigner A, Stoica GE, McDonnell K, Wellstein A (April 2002). "Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth". The Journal of Biological Chemistry. 277 (16): 14153–14158. doi:10.1074/jbc.M112354200. PMID 11809760.
Stoica GE, Kuo A, Aigner A, Sunitha I, Souttou B, Malerczyk C, et al. (May 2001). "Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin". The Journal of Biological Chemistry. 276 (20): 16772–16779. doi:10.1074/jbc.M010660200. PMID 11278720.
Murugan AK, Xing M (July 2011). "Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene". Cancer Research. 71 (13): 4403–4411. doi:10.1158/0008-5472.CAN-10-4041. PMC 3129369. PMID 21596819.
Gambacorti-Passerini C, Messa C, Pogliani EM (February 2011). "Crizotinib in anaplastic large-cell lymphoma". The New England Journal of Medicine. 364 (8): 775–776. doi:10.1056/NEJMc1013224. PMID 21345110.
Gambacorti Passerini C, Farina F, Stasia A, Redaelli S, Ceccon M, Mologni L, et al. (February 2014). "Crizotinib in advanced, chemoresistant anaplastic lymphoma kinase-positive lymphoma patients". Journal of the National Cancer Institute. 106 (2): djt378. doi:10.1093/jnci/djt378. PMID 24491302.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ALK anaplastic lymphoma kinase (Ki-1)".
Lorén CE, Scully A, Grabbe C, Edeen PT, Thomas J, McKeown M, et al. (June 2001). "Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo". Genes to Cells. 6 (6): 531–544. doi:10.1046/j.1365-2443.2001.00440.x. PMC 1975818. PMID 11442633.
Yao S, Cheng M, Zhang Q, Wasik M, Kelsh R, Winkler C (May 2013). "Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish". PLOS ONE. 8 (5): e63757. Bibcode:2013PLoSO...863757Y. doi:10.1371/journal.pone.0063757. PMC 3648509. PMID 23667670.
Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, et al. (September 2015). "FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase". eLife. 4: e09811. doi:10.7554/eLife.09811. PMC 4658194. PMID 26418745.
Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, et al. (December 2015). "Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions". Proceedings of the National Academy of Sciences of the United States of America. 112 (52): 15862–15867. Bibcode:2015PNAS..11215862R. doi:10.1073/pnas.1520099112. PMC 4702955. PMID 26630010.
Zhang H, Pao LI, Zhou A, Brace AD, Halenbeck R, Hsu AW, et al. (November 2014). "Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome". Proceedings of the National Academy of Sciences of the United States of America. 111 (44): 15741–15745. Bibcode:2014PNAS..11115741Z. doi:10.1073/pnas.1412009111. PMC 4226105. PMID 25331893.
Reiner DJ, Ailion M, Thomas JH, Meyer BJ (August 2008). "C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling". Current Biology. 18 (15): 1101–1109. Bibcode:2008CBio...18.1101R. doi:10.1016/j.cub.2008.06.060. PMC 3489285. PMID 18674914.
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, et al. (April 1996). "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)". Proceedings of the National Academy of Sciences of the United States of America. 93 (9): 4181–4186. Bibcode:1996PNAS...93.4181F. doi:10.1073/pnas.93.9.4181. PMC 39508. PMID 8633037.
Bai RY, Dieter P, Peschel C, Morris SW, Duyster J (December 1998). "Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity". Molecular and Cellular Biology. 18 (12): 6951–6961. doi:10.1128/mcb.18.12.6951. PMC 109278. PMID 9819383.
Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, et al. (September 2011). "The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning". PLOS Genetics. 7 (9): e1002281. doi:10.1371/journal.pgen.1002281. PMC 3174217. PMID 21949657.
Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R, et al. (January 2005). "Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma". Blood. 105 (2): 827–829. doi:10.1182/blood-2004-06-2125. PMC 1382060. PMID 15374880.
Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, et al. (November 2008). "The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation". Cancer Research. 68 (21): 8899–8907. doi:10.1158/0008-5472.CAN-08-2568. PMC 2596920. PMID 18974134.
Ambrogio C, Voena C, Manazza AD, Piva R, Riera L, Barberis L, et al. (December 2005). "p130Cas mediates the transforming properties of the anaplastic lymphoma kinase". Blood. 106 (12): 3907–3916. doi:10.1182/blood-2005-03-1204. PMC 1895100. PMID 16105984.
Hegazy SA, Wang P, Anand M, Ingham RJ, Gelebart P, Lai R (June 2010). "The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions". The Journal of Biological Chemistry. 285 (26): 19813–19820. doi:10.1074/jbc.M110.121988. PMC 2888392. PMID 20424160.
Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, et al. (September 2011). "The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness". The Journal of Biological Chemistry. 286 (37): 32105–32114. doi:10.1074/jbc.M111.227512. PMC 3173219. PMID 21737449.
Palmer RH, Vernersson E, Grabbe C, Hallberg B (May 2009). "Anaplastic lymphoma kinase: signalling in development and disease". The Biochemical Journal. 420 (3): 345–361. doi:10.1042/BJ20090387. PMC 2708929. PMID 19459784.
Witek B, El Wakil A, Nord C, Ahlgren U, Eriksson M, Vernersson-Lindahl E, et al. (May 2015). "Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism". PLOS ONE. 10 (5): e0123542. Bibcode:2015PLoSO..1023542W. doi:10.1371/journal.pone.0123542. PMC 4425494. PMID 25955180.
Rohrbough J, Broadie K (October 2010). "Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap". Development. 137 (20): 3523–3533. doi:10.1242/dev.047878. PMC 2947762. PMID 20876658.
Rohrbough J, Kent KS, Broadie K, Weiss JB (March 2013). "Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture". Developmental Neurobiology. 73 (3): 189–208. doi:10.1002/dneu.22056. PMC 3565053. PMID 22949158.
Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, et al. (Jul 2011). "An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol". PLOS ONE. 6 (7): e22636. Bibcode:2011PLoSO...622636L. doi:10.1371/journal.pone.0022636. PMC 3142173. PMID 21799923.
Schweitzer P, Cates-Gatto C, Varodayan FP, Nadav T, Roberto M, Lasek AW, et al. (August 2016). "Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice". Neuropharmacology. 107: 1–8. doi:10.1016/j.neuropharm.2016.03.003. PMC 4912883. PMID 26946429.
Dutton JW, Chen H, You C, Brodie MS, Lasek AW (May 2017). "Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area". Addiction Biology. 22 (3): 665–678. doi:10.1111/adb.12358. PMC 4940304. PMID 26752591.
Mangieri RA, Maier EY, Buske TR, Lasek AW, Morrisett RA (Aug 2017). "Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell". Frontiers in Pharmacology. 8: 533. doi:10.3389/fphar.2017.00533. PMC 5559467. PMID 28860990.
Bai L, Sehgal A (November 2015). "Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep". PLOS Genetics. 11 (11): e1005611. doi:10.1371/journal.pgen.1005611. PMC 4633181. PMID 26536237.
Gouzi JY, Bouraimi M, Roussou IG, Moressis A, Skoulakis EM (August 2018). "The Drosophila Receptor Tyrosine Kinase Alk Constrains Long-Term Memory Formation". The Journal of Neuroscience. 38 (35): 7701–7712. doi:10.1523/JNEUROSCI.0784-18.2018. PMC 6705970. PMID 30030398.
Woodling NS, Aleyakpo B, Dyson MC, Minkley LJ, Rajasingam A, Dobson AJ, et al. (May 2020). "The neuronal receptor tyrosine kinase Alk is a target for longevity". Aging Cell. 19 (5): e13137. doi:10.1111/acel.13137. PMC 7253064. PMID 32291952.
Patcas A, Chis AF, Militaru CF, Bordea IR, Rajnoveanu R, Coza OF, et al. (February 2022). "An insight into lung cancer: a comprehensive review exploring ALK TKI and mechanisms of resistance". Bosnian Journal of Basic Medical Sciences. 22 (1): 1–13. doi:10.17305/bjbms.2021.5859. PMC 8860314. PMID 34082691.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. (February 2011). "International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma". Journal of Thoracic Oncology. 6 (2): 244–285. doi:10.1097/JTO.0b013e318206a221. PMC 4513953. PMID 21252716.
Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, et al. (October 2008). "Identification of ALK as a major familial neuroblastoma predisposition gene". Nature. 455 (7215): 930–935. Bibcode:2008Natur.455..930M. doi:10.1038/nature07261. PMC 2672043. PMID 18724359.
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, et al. (August 2000). "TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors". The American Journal of Pathology. 157 (2): 377–384. doi:10.1016/S0002-9440(10)64550-6. PMC 1850130. PMID 10934142.
Jazii FR, Najafi Z, Malekzadeh R, Conrads TP, Ziaee AA, Abnet C, et al. (November 2006). "Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer". World Journal of Gastroenterology. 12 (44): 7104–7112. doi:10.3748/wjg.v12.i44.7104. PMC 4087770. PMID 17131471.
Murugan AK, Xing M (July 2011). "Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene". Cancer Research. 71 (13): 4403–4411. doi:10.1158/0008-5472.CAN-10-4041. PMC 3129369. PMID 21596819.

roche.com

diagnostics.roche.com

"VENTANA ALK (D5F3) CDx Assay". Diagnostics.

semanticscholar.org

api.semanticscholar.org

Liao EH, Hung W, Abrams B, Zhen M (July 2004). "An SCF-like ubiquitin ligase complex that controls presynaptic differentiation". Nature. 430 (6997): 345–350. Bibcode:2004Natur.430..345L. doi:10.1038/nature02647. PMID 15208641. S2CID 4428538.
Englund C, Lorén CE, Grabbe C, Varshney GK, Deleuil F, Hallberg B, et al. (October 2003). "Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion". Nature. 425 (6957): 512–516. Bibcode:2003Natur.425..512E. doi:10.1038/nature01950. PMID 14523447. S2CID 4425423.
Lee HH, Norris A, Weiss JB, Frasch M (October 2003). "Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers". Nature. 425 (6957): 507–512. Bibcode:2003Natur.425..507L. doi:10.1038/nature01916. PMID 14523446. S2CID 4424062.
Hallberg B, Palmer RH (October 2013). "Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology". Nature Reviews. Cancer. 13 (10): 685–700. doi:10.1038/nrc3580. PMID 24060861. S2CID 21345361.
Degoutin J, Vigny M, Gouzi JY (February 2007). "ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation". FEBS Letters. 581 (4): 727–734. doi:10.1016/j.febslet.2007.01.039. PMID 17274988. S2CID 40978851.
Bassermann F, von Klitzing C, Münch S, Bai RY, Kawaguchi H, Morris SW, et al. (July 2005). "NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry". Cell. 122 (1): 45–57. doi:10.1016/j.cell.2005.04.034. PMID 16009132. S2CID 16122567.
Weiss JB, Xue C, Benice T, Xue L, Morris SW, Raber J (January 2012). "Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis". Pharmacology, Biochemistry, and Behavior. 100 (3): 566–574. doi:10.1016/j.pbb.2011.10.024. PMID 22079349. S2CID 2386055.
Bazigou E, Apitz H, Johansson J, Lorén CE, Hirst EM, Chen PL, et al. (March 2007). "Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila". Cell. 128 (5): 961–975. doi:10.1016/j.cell.2007.02.024. PMID 17350579. S2CID 10341647.
Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP (August 2011). "Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila". Cell. 146 (3): 435–447. doi:10.1016/j.cell.2011.06.040. PMID 21816278. S2CID 4287148.
Orthofer M, Valsesia A, Mägi R, Wang QP, Kaczanowska J, Kozieradzki I, et al. (June 2020). "Identification of ALK in Thinness". Cell. 181 (6): 1246–1262.e22. doi:10.1016/j.cell.2020.04.034. PMID 32442405. S2CID 218762956.
Mologni L (July 2012). "Inhibitors of the anaplastic lymphoma kinase". Expert Opinion on Investigational Drugs. 21 (7): 985–994. doi:10.1517/13543784.2012.690031. PMID 22612599. S2CID 24564015.
Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B, et al. (August 2002). "Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor". Genes, Chromosomes & Cancer. 34 (4): 354–362. doi:10.1002/gcc.10033. PMID 12112524. S2CID 22808049.
Sugawara E, Togashi Y, Kuroda N, Sakata S, Hatano S, Asaka R, et al. (September 2012). "Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method". Cancer. 118 (18): 4427–4436. doi:10.1002/cncr.27391. PMID 22252991. S2CID 9387860.
Mariño-Enríquez A, Ou WB, Weldon CB, Fletcher JA, Pérez-Atayde AR (March 2011). "ALK rearrangement in sickle cell trait-associated renal medullary carcinoma". Genes, Chromosomes & Cancer. 50 (3): 146–153. doi:10.1002/gcc.20839. PMID 21213368. S2CID 39004672.