Aspartame (English Wikipedia)

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Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW, et al. (2007). "Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies". Critical Reviews in Toxicology. 37 (8): 629–727. doi:10.1080/10408440701516184. PMID 17828671. S2CID 7316097.
Butchko HH, Stargel WW, Comer CP, Mayhew DA, Benninger C, Blackburn GL, et al. (April 2002). "Aspartame: review of safety". Regulatory Toxicology and Pharmacology. 35 (2 Pt 2): S1–93. doi:10.1006/rtph.2002.1542. PMID 12180494.
Nahon DF, Roozen JP, de Graaf C (February 1998). "Sensory evaluation of mixtures of maltitol or aspartame, sucrose and an orange aroma". Chemical Senses. 23 (1): 59–66. doi:10.1093/chemse/23.1.59. PMID 9530970.
EFSA Panel On Food Additives And Nutrient Sources Added To Food (10 December 2013). "Scientific Opinion on the re-evaluation of aspartame (E 951) as a food additive". EFSA Journal. 11 (12): 3496. doi:10.2903/j.efsa.2013.3496. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
Renwick AG (April 2006). "The intake of intense sweeteners – an update review" (PDF). Food Additives and Contaminants. 23 (4): 327–338. doi:10.1080/02652030500442532. PMID 16546879. S2CID 27351427. Archived (PDF) from the original on 23 August 2022. Retrieved 22 April 2022.
Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, et al. (July 2017). "Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies". CMAJ. 189 (28): E929–E939. doi:10.1503/cmaj.161390. PMC 5515645. PMID 28716847.
Rogers PJ, Hogenkamp PS, de Graaf C, Higgs S, Lluch A, Ness AR, et al. (March 2016). "Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies". International Journal of Obesity. 40 (3): 381–394. doi:10.1038/ijo.2015.177. PMC 4786736. PMID 26365102.
Miller PE, Perez V (September 2014). "Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies". The American Journal of Clinical Nutrition. 100 (3): 765–777. doi:10.3945/ajcn.113.082826. PMC 4135487. PMID 24944060.
Santos NC, de Araujo LM, De Luca Canto G, Guerra EN, Coelho MS, Borin MF (April 2017). "Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials". Critical Reviews in Food Science and Nutrition. 58 (12): 2068–2081. doi:10.1080/10408398.2017.1304358. PMID 28394643. S2CID 43863824.
Marinovich M, Galli CL, Bosetti C, Gallus S, La Vecchia C (October 2013). "Aspartame, low-calorie sweeteners and disease: regulatory safety and epidemiological issues". Food and Chemical Toxicology. 60: 109–115. doi:10.1016/j.fct.2013.07.040. PMID 23891579.
Kirkland D, Gatehouse D (October 2015). "Aspartame: A review of genotoxicity data". Food and Chemical Toxicology. 84: 161–168. doi:10.1016/j.fct.2015.08.021. PMID 26321723.
Haighton L, Roberts A, Jonaitis T, Lynch B (1 April 2019). "Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria". Regulatory Toxicology and Pharmacology. 103: 352–362. doi:10.1016/j.yrtph.2019.01.033. ISSN 0273-2300. PMID 30716379. S2CID 73442105.
Riboli E, Beland FA, Lachenmeier DW, Marques MM, Phillips DH, Schernhammer E, et al. (August 2023). "Carcinogenicity of aspartame, methyleugenol, and isoeugenol". The Lancet Oncology. 24 (8): 848–850. doi:10.1016/S1470-2045(23)00341-8. hdl:2158/1320996. PMID 37454664. S2CID 259894482. Archived from the original on 14 July 2023. Retrieved 14 July 2023.
Naddaf M (14 July 2023). "Aspartame is a possible carcinogen: the science behind the decision". Nature. doi:10.1038/d41586-023-02306-0. PMID 37452160. S2CID 259904544. Archived from the original on 30 July 2023. Retrieved 14 July 2023.
Baker-Smith CM, de Ferranti SD, Cochran WJ, et al. (November 2019). "Policy Statement: The Use of Nonnutritive Sweeteners in Children". Pediatrics. 144 (5). doi:10.1542/peds.2019-2765. PMID 31659005.
Sun-Edelstein C, Mauskop A (June 2009). "Foods and supplements in the management of migraine headaches". The Clinical Journal of Pain. 25 (5): 446–452. CiteSeerX 10.1.1.530.1223. doi:10.1097/AJP.0b013e31819a6f65. PMID 19454881. S2CID 3042635.
Li S, Geng J, Wu G, Gao X, Fu Y, Ren H (February 2018). "Removal of artificial sweeteners and their effects on microbial communities in sequencing batch reactors". Scientific Reports. 8 (1): 3399. Bibcode:2018NatSR...8.3399L. doi:10.1038/s41598-018-21564-x. PMC 5821853. PMID 29467367. S2CID 3384839.
Lange FT, Scheurer M, Brauch HJ (July 2012). "Artificial sweeteners – a recently recognized class of emerging environmental contaminants: a review". Analytical and Bioanalytical Chemistry. 403 (9): 2503–2518. doi:10.1007/s00216-012-5892-z. PMID 22543693. S2CID 33178173.
Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (April 2002). "Human receptors for sweet and umami taste". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4692–4696. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, et al. (March 2002). "An amino-acid taste receptor". Nature. 416 (6877): 199–202. Bibcode:2002Natur.416..199N. doi:10.1038/nature726. PMID 11894099. S2CID 1730089.
Ahmad SY, Friel JK, Mackay DS (September 2020). "Effect of sucralose and aspartame on glucose metabolism and gut hormones". Nutrition Reviews. 78 (9): 725–746. doi:10.1093/nutrit/nuz099. PMID 32065635.
Lin SY, Cheng YD (October 2000). "Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system". Food Additives and Contaminants. 17 (10): 821–827. doi:10.1080/026520300420385. PMID 11103265. S2CID 10065876.
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Panel on Food Additives and Nutrient Sources added to Food (2006). "Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a new long-term carcinogenicity study on aspartame". The EFSA Journal. 356 (5): 1–44. doi:10.2903/j.efsa.2006.356.
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Li S, Geng J, Wu G, Gao X, Fu Y, Ren H (February 2018). "Removal of artificial sweeteners and their effects on microbial communities in sequencing batch reactors". Scientific Reports. 8 (1): 3399. Bibcode:2018NatSR...8.3399L. doi:10.1038/s41598-018-21564-x. PMC 5821853. PMID 29467367. S2CID 3384839.
Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (April 2002). "Human receptors for sweet and umami taste". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4692–4696. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
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Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW, et al. (2007). "Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies". Critical Reviews in Toxicology. 37 (8): 629–727. doi:10.1080/10408440701516184. PMID 17828671. S2CID 7316097.
Butchko HH, Stargel WW, Comer CP, Mayhew DA, Benninger C, Blackburn GL, et al. (April 2002). "Aspartame: review of safety". Regulatory Toxicology and Pharmacology. 35 (2 Pt 2): S1–93. doi:10.1006/rtph.2002.1542. PMID 12180494.
Nahon DF, Roozen JP, de Graaf C (February 1998). "Sensory evaluation of mixtures of maltitol or aspartame, sucrose and an orange aroma". Chemical Senses. 23 (1): 59–66. doi:10.1093/chemse/23.1.59. PMID 9530970.
Renwick AG (April 2006). "The intake of intense sweeteners – an update review" (PDF). Food Additives and Contaminants. 23 (4): 327–338. doi:10.1080/02652030500442532. PMID 16546879. S2CID 27351427. Archived (PDF) from the original on 23 August 2022. Retrieved 22 April 2022.
Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, et al. (July 2017). "Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies". CMAJ. 189 (28): E929–E939. doi:10.1503/cmaj.161390. PMC 5515645. PMID 28716847.
Rogers PJ, Hogenkamp PS, de Graaf C, Higgs S, Lluch A, Ness AR, et al. (March 2016). "Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies". International Journal of Obesity. 40 (3): 381–394. doi:10.1038/ijo.2015.177. PMC 4786736. PMID 26365102.
Miller PE, Perez V (September 2014). "Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies". The American Journal of Clinical Nutrition. 100 (3): 765–777. doi:10.3945/ajcn.113.082826. PMC 4135487. PMID 24944060.
Santos NC, de Araujo LM, De Luca Canto G, Guerra EN, Coelho MS, Borin MF (April 2017). "Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials". Critical Reviews in Food Science and Nutrition. 58 (12): 2068–2081. doi:10.1080/10408398.2017.1304358. PMID 28394643. S2CID 43863824.
Marinovich M, Galli CL, Bosetti C, Gallus S, La Vecchia C (October 2013). "Aspartame, low-calorie sweeteners and disease: regulatory safety and epidemiological issues". Food and Chemical Toxicology. 60: 109–115. doi:10.1016/j.fct.2013.07.040. PMID 23891579.
Kirkland D, Gatehouse D (October 2015). "Aspartame: A review of genotoxicity data". Food and Chemical Toxicology. 84: 161–168. doi:10.1016/j.fct.2015.08.021. PMID 26321723.
Haighton L, Roberts A, Jonaitis T, Lynch B (1 April 2019). "Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria". Regulatory Toxicology and Pharmacology. 103: 352–362. doi:10.1016/j.yrtph.2019.01.033. ISSN 0273-2300. PMID 30716379. S2CID 73442105.
Riboli E, Beland FA, Lachenmeier DW, Marques MM, Phillips DH, Schernhammer E, et al. (August 2023). "Carcinogenicity of aspartame, methyleugenol, and isoeugenol". The Lancet Oncology. 24 (8): 848–850. doi:10.1016/S1470-2045(23)00341-8. hdl:2158/1320996. PMID 37454664. S2CID 259894482. Archived from the original on 14 July 2023. Retrieved 14 July 2023.
Naddaf M (14 July 2023). "Aspartame is a possible carcinogen: the science behind the decision". Nature. doi:10.1038/d41586-023-02306-0. PMID 37452160. S2CID 259904544. Archived from the original on 30 July 2023. Retrieved 14 July 2023.
Baker-Smith CM, de Ferranti SD, Cochran WJ, et al. (November 2019). "Policy Statement: The Use of Nonnutritive Sweeteners in Children". Pediatrics. 144 (5). doi:10.1542/peds.2019-2765. PMID 31659005.
Sun-Edelstein C, Mauskop A (June 2009). "Foods and supplements in the management of migraine headaches". The Clinical Journal of Pain. 25 (5): 446–452. CiteSeerX 10.1.1.530.1223. doi:10.1097/AJP.0b013e31819a6f65. PMID 19454881. S2CID 3042635.
Li S, Geng J, Wu G, Gao X, Fu Y, Ren H (February 2018). "Removal of artificial sweeteners and their effects on microbial communities in sequencing batch reactors". Scientific Reports. 8 (1): 3399. Bibcode:2018NatSR...8.3399L. doi:10.1038/s41598-018-21564-x. PMC 5821853. PMID 29467367. S2CID 3384839.
Lange FT, Scheurer M, Brauch HJ (July 2012). "Artificial sweeteners – a recently recognized class of emerging environmental contaminants: a review". Analytical and Bioanalytical Chemistry. 403 (9): 2503–2518. doi:10.1007/s00216-012-5892-z. PMID 22543693. S2CID 33178173.
Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (April 2002). "Human receptors for sweet and umami taste". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4692–4696. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, et al. (March 2002). "An amino-acid taste receptor". Nature. 416 (6877): 199–202. Bibcode:2002Natur.416..199N. doi:10.1038/nature726. PMID 11894099. S2CID 1730089.
Ahmad SY, Friel JK, Mackay DS (September 2020). "Effect of sucralose and aspartame on glucose metabolism and gut hormones". Nutrition Reviews. 78 (9): 725–746. doi:10.1093/nutrit/nuz099. PMID 32065635.
Lin SY, Cheng YD (October 2000). "Simultaneous formation and detection of the reaction product of solid-state aspartame sweetener by FT-IR/DSC microscopic system". Food Additives and Contaminants. 17 (10): 821–827. doi:10.1080/026520300420385. PMID 11103265. S2CID 10065876.
Yagasaki M, Hashimoto S (November 2008). "Synthesis and application of dipeptides; current status and perspectives". Applied Microbiology and Biotechnology. 81 (1): 13–22. doi:10.1007/s00253-008-1590-3. PMID 18795289. S2CID 10200090.

ncbi.nlm.nih.gov

Azad MB, Abou-Setta AM, Chauhan BF, Rabbani R, Lys J, Copstein L, et al. (July 2017). "Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies". CMAJ. 189 (28): E929–E939. doi:10.1503/cmaj.161390. PMC 5515645. PMID 28716847.
Rogers PJ, Hogenkamp PS, de Graaf C, Higgs S, Lluch A, Ness AR, et al. (March 2016). "Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies". International Journal of Obesity. 40 (3): 381–394. doi:10.1038/ijo.2015.177. PMC 4786736. PMID 26365102.
Miller PE, Perez V (September 2014). "Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies". The American Journal of Clinical Nutrition. 100 (3): 765–777. doi:10.3945/ajcn.113.082826. PMC 4135487. PMID 24944060.
Li S, Geng J, Wu G, Gao X, Fu Y, Ren H (February 2018). "Removal of artificial sweeteners and their effects on microbial communities in sequencing batch reactors". Scientific Reports. 8 (1): 3399. Bibcode:2018NatSR...8.3399L. doi:10.1038/s41598-018-21564-x. PMC 5821853. PMID 29467367. S2CID 3384839.
Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (April 2002). "Human receptors for sweet and umami taste". Proceedings of the National Academy of Sciences of the United States of America. 99 (7): 4692–4696. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.

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Haighton L, Roberts A, Jonaitis T, Lynch B (1 April 2019). "Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria". Regulatory Toxicology and Pharmacology. 103: 352–362. doi:10.1016/j.yrtph.2019.01.033. ISSN 0273-2300. PMID 30716379. S2CID 73442105.