BIA 10-2474 (English Wikipedia)

Rogers MB (29 January 2016). "Will Death in French Drug Trial Lead to Tighter Phase 1 Rules?". www.alzforum.org; Biomedical Research Forum. Retrieved 5 January 2016.

archive.today

"Essai clinique BIA-102474-101- Bial/Biotrial : Chronologie". Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). Archived from the original on 2016-01-28. Retrieved 2016-01-28.
"Six hospitalized in Bial clinical trial in France". BioWorld.com. Archived from the original on 2016-01-16. Retrieved 2016-01-17.

bbc.co.uk

news.bbc.co.uk

"Six taken ill after drug trials". BBC. 15 March 2006. Retrieved 5 February 2016.

bbc.com

"France clinical trial: 90 given drug, one man brain-dead". BBC. January 15, 2016. Retrieved January 16, 2016.
"France clinical trial: 'No known antidote' to drug". BBC News. 15 January 2016. Retrieved 18 January 2016.

bfarm.de

"Zwischenfall bei einer klinischen Prüfung in Frankreich: keine vergleichbaren Fälle in Deutschland. Probandensicherheit hat bei der Genehmigung klinischer Prüfungen höchste Priorität". Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM). 19 January 2016. Retrieved 26 January 2016.

bial.com

"News Release - Phase I Clinical Trial Rennes". www.bial.com. Archived from the original on 22 January 2016. Retrieved 21 January 2016.

biotrial.com

"PRESS RELEASE - IGAS Status Report: Clarifications from Biotrial". www.biotrial.com. 5 February 2016. Archived from the original on 6 February 2016. Retrieved 6 February 2016.
"Message from Biotrial". www.biotrial.com. 15 January 2016. Archived from the original on 2016-06-28. Retrieved 17 January 2016.
"Communication from Biotrial February 5th, 2016". www.biotrial.com. 5 February 2016. Archived from the original on 26 February 2016. Retrieved 6 February 2016.

bioworld.com

"Six hospitalized in Bial clinical trial in France". BioWorld.com. Archived from the original on 2016-01-16. Retrieved 2016-01-17.

bloomberg.com

Benoit A, Kitamura M (15 January 2016). "France Ties Brain-Dead Person to Tests of Bial-Portela Drug". Bloomberg.com.

breizh-info.com

"Essai thérapeutique mortel à Biotrial Rennes. Le contenu du test du Bia 10 – 2474 de Bial révélé [exclusif]". Breizh-info.com. 15 January 2016. Retrieved 17 January 2016.

cdsouthan.blogspot.se

Southan C (23 January 2016). "Molecular details related to BIA 10-2474". Retrieved 29 January 2016.

channel4.com

blogs.channel4.com

Macdonald V (2 February 2016). "French drug trial death: interview with victim's brother". Channel 4 News. Retrieved 6 February 2016.

chu-rennes.fr

"COMMUNIQUE DE PRESSE: Point de situation n°2 concernant les patients hospitalisés au CHU et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 17 January 2016. Archived from the original (PDF) on 3 February 2016. Retrieved 18 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°4 concernant les patients hospitalisés au CHU de Rennes et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 19 January 2016. Archived from the original (PDF) on 22 January 2016. Retrieved 25 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°5 concernant les patients hospitalisés au CHU de Rennes et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 20 January 2016. Archived from the original (PDF) on 3 February 2016. Retrieved 21 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°7 concernant les patients hospitalisés dans des structures proches de leur domicile et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 26 January 2016. Archived from the original (PDF) on 5 February 2016. Retrieved 27 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°6 concernant les patients hospitalisés au CHU de Rennes et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 21 January 2016. Archived from the original (PDF) on 3 February 2016. Retrieved 25 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°3 concernant les patients hospitalisés au CHU et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 18 January 2016. Archived from the original (PDF) on 22 January 2016. Retrieved 24 January 2016.

clinicaltrials.gov

"Seven studies found for: jnj-42165279". Clinicaltrials.gov. Retrieved 2016-01-19.
"2 studies found for: V158866". Clinicaltrials.gov. Retrieved 2016-01-19.

collabchem.com

Ekins S (21 January 2016). "Lets do it all again updating predictions for the 'real' BIA 10-2474". Collaborative Chemistry Forum. Retrieved 5 February 2016.

doi.org

Otrubova K, Ezzili C, Boger DL (August 2011). "The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)". Bioorganic & Medicinal Chemistry Letters. 21 (16): 4674–4685. doi:10.1016/j.bmcl.2011.06.096. PMC 3146581. PMID 21764305.
Bisogno T, Maccarrone M (May 2013). "Latest advances in the discovery of fatty acid amide hydrolase inhibitors". Expert Opinion on Drug Discovery. 8 (5): 509–522. doi:10.1517/17460441.2013.780021. PMID 23488865. S2CID 33195822.
Casassus B (23 January 2016). "France investigates drug trial disaster" (PDF). The Lancet. 387 (10016): 326. doi:10.1016/S0140-6736(16)00154-9. PMID 26842439. S2CID 31310363.
Callaway E, Butler D (22 January 2016). "Researchers question design of fatal French clinical trial". Nature News. doi:10.1038/nature.2016.19221. S2CID 181956785.
Butler D, Callaway E (January 2016). "Scientists in the dark after French clinical trial proves fatal". Nature. 529 (7586): 263–264. Bibcode:2016Natur.529..263B. doi:10.1038/nature.2016.19189. PMID 26791697.
Casassus B (February 2016). "France releases interim report on drug trial disaster". Lancet. 387 (10019): 634–635. doi:10.1016/S0140-6736(16)00318-4. PMID 26876704. S2CID 39093208.
Feldwisch-Drentrup H (25 July 2016). "Europe overhauls rules for 'first-in-human' trials in wake of French disaster". Science. doi:10.1126/science.aag0686. Retrieved 19 October 2016.
Kerbrat A, Ferré JC, Fillatre P, Ronzière T, Vannier S, Carsin-Nicol B, et al. (November 2016). "Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase". The New England Journal of Medicine. 375 (18): 1717–1725. doi:10.1056/NEJMoa1604221. PMID 27806235.
Randerson J (22 December 2016). "Fatal French clinical trial failed to check data before raising drug dose". Nature. doi:10.1038/nature.2016.21190. S2CID 78424247. Retrieved 18 May 2018.
Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, et al. (June 2014). "Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain". ACS Medicinal Chemistry Letters. 5 (6): 717–721. doi:10.1021/ml5001239. PMC 4060928. PMID 24944750.
Ahn K, Johnson DS, Cravatt BF (July 2009). "Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders". Expert Opinion on Drug Discovery. 4 (7): 763–784. doi:10.1517/17460440903018857. PMC 2882713. PMID 20544003.
Shanks KG, Behonick GS, Dahn T, Terrell A (October 2013). "Identification of novel third-generation synthetic cannabinoids in products by ultra-performance liquid chromatography and time-of-flight mass spectrometry". Journal of Analytical Toxicology. 37 (8): 517–525. doi:10.1093/jat/bkt062. PMID 23946450.
Uchiyama N, Matsuda S, Kawamura M, Shimokawa Y, Kikura-Hanajiri R, Aritake K, et al. (October 2014). "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products". Forensic Science International. 243: 1–13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262.

espacenet.com

worldwide.espacenet.com

WO 2015012708A1, Da Costa CP, Rosa P, Gusmão de Noronha R, Kiss LE, "Imidazolecarboxamides and their use as FAAH inhibitors", published 29 January 2015, assigned to Bial Portela & CA SA.
WO 2015016729, Kiss LE, Gusmão de Noronha R, Da Costa CP, Rosa P, Pinto R, "Urea compounds and their use as FAAH enzyme inhibitors", published Feb 5, 2015, assigned to Bial Portela & CA SA.
WO 2010074588, Kiss LE, Learmonth WO2010074588A2, Da Costa CP, Rosa P, Gusmão de Noronha R, Palma PN, Soares da Siliva PM, Beliaev A, "Pharmaceutical Compounds", published 1 July 2010, assigned to Bial Portela & CA SA.

europa.eu

ema.europa.eu

"Strategies to identify and mitigate risks for first-in-human clinical trials with investigational medicinal products (CHMP/SWP/28367/07)" (PDF). European Medicines Agency. 1 September 2007. Retrieved 22 January 2016.
"Proposals to revise guidance on first-in-human clinical trials". European Medicines Agency, London. 21 July 2016. Retrieved 19 October 2016.

fda.gov

"FDA works with regulatory partners to understand French-based Biotrial phase 1 clinical study". US Food and Drug Administration. 22 January 2016. Retrieved 23 January 2016.

ft.com

Ward A, Wise P (24 January 2016). "Drugmaker in fatal trial received EU funds". The Financial Times. Retrieved 24 January 2016.

go.com

abcnews.go.com

Adamson B (January 15, 2016). "Botched Drug Trial Leaves 1 Brain Dead, 5 in Hospital". ABC, AP. Retrieved January 16, 2016.

harvard.edu

ui.adsabs.harvard.edu

Butler D, Callaway E (January 2016). "Scientists in the dark after French clinical trial proves fatal". Nature. 529 (7586): 263–264. Bibcode:2016Natur.529..263B. doi:10.1038/nature.2016.19189. PMID 26791697.

in-pharmatechnologist.com

MacDonald G (26 February 2016). "Bial cannot rule out link between BIA 10-2474 and lung lesions in study dogs". In-Pharma Technologist. Retrieved 15 March 2016.
MacDonald G (19 January 2016). "FAAH inhibitor safety under microscope after Bial drug trial death". In-Pharma Technologist. Retrieved 5 February 2016.

irishtimes.com

Marlowe L (1 March 2016). "Survivor of lethal French drug trial speaks out". The Irish Times. Retrieved 17 March 2016.

janssen.com

"Janssen Research & Development, LLC Voluntarily Suspends Dosing in Phase 2 Clinical Trials of Experimental Treatment for Mood Disorders". Janssen.com. 17 January 2016. Archived from the original on 2016-01-25. Retrieved 21 January 2016.

ladepeche.fr

"Accident "inédit" lors d'un essai clinique: un homme en état de mort cérébrale, cinq hospitalisés". La Depeche. January 15, 2016. Retrieved January 18, 2016.

ledauphine.com

"ESSAI CLINIQUE MORTEL. Le frère de la victime : "Je lui ai dit de ne pas le faire"". Le Dauphine. 11 March 2016. Retrieved 15 March 2016.
"France/Monde - Essai thérapeutique : 90 personnes ont pris la molécule". Ledauphine.com. Retrieved 2016-01-17.

lefigaro.fr

sante.lefigaro.fr

"Drame de Rennes : le protocole de l'essai clinique en accusation". sante.lefigaro.fr. 2016-01-21. Retrieved 2016-01-21.

lemonde.fr

"Essai clinique de Rennes : " Des choses ont été cachées ", selon les proches de la victime". Le Monde.fr. Le Monde. 11 March 2016. Retrieved 15 March 2016.
"Ce que l'on sait de l'accident survenu lors d'un essai clinique à Rennes", Le Monde, 15 January 2016

merck.com

"Merck Pipeline, Oct 2009" (PDF). Merck. 15 October 2009. Archived from the original (PDF) on 20 October 2016. Retrieved 15 January 2016.

nature.com

Callaway E, Butler D (22 January 2016). "Researchers question design of fatal French clinical trial". Nature News. doi:10.1038/nature.2016.19221. S2CID 181956785.
Randerson J (22 December 2016). "Fatal French clinical trial failed to check data before raising drug dose". Nature. doi:10.1038/nature.2016.21190. S2CID 78424247. Retrieved 18 May 2018.

newscientist.com

Mackenzie D. "Six in hospital after French pain relief drug trial goes wrong". New Scientist.

nih.gov

pubmed.ncbi.nlm.nih.gov

Otrubova K, Ezzili C, Boger DL (August 2011). "The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)". Bioorganic & Medicinal Chemistry Letters. 21 (16): 4674–4685. doi:10.1016/j.bmcl.2011.06.096. PMC 3146581. PMID 21764305.
Bisogno T, Maccarrone M (May 2013). "Latest advances in the discovery of fatty acid amide hydrolase inhibitors". Expert Opinion on Drug Discovery. 8 (5): 509–522. doi:10.1517/17460441.2013.780021. PMID 23488865. S2CID 33195822.
Casassus B (23 January 2016). "France investigates drug trial disaster" (PDF). The Lancet. 387 (10016): 326. doi:10.1016/S0140-6736(16)00154-9. PMID 26842439. S2CID 31310363.
Butler D, Callaway E (January 2016). "Scientists in the dark after French clinical trial proves fatal". Nature. 529 (7586): 263–264. Bibcode:2016Natur.529..263B. doi:10.1038/nature.2016.19189. PMID 26791697.
Casassus B (February 2016). "France releases interim report on drug trial disaster". Lancet. 387 (10019): 634–635. doi:10.1016/S0140-6736(16)00318-4. PMID 26876704. S2CID 39093208.
Kerbrat A, Ferré JC, Fillatre P, Ronzière T, Vannier S, Carsin-Nicol B, et al. (November 2016). "Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase". The New England Journal of Medicine. 375 (18): 1717–1725. doi:10.1056/NEJMoa1604221. PMID 27806235.
Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, et al. (June 2014). "Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain". ACS Medicinal Chemistry Letters. 5 (6): 717–721. doi:10.1021/ml5001239. PMC 4060928. PMID 24944750.
Ahn K, Johnson DS, Cravatt BF (July 2009). "Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders". Expert Opinion on Drug Discovery. 4 (7): 763–784. doi:10.1517/17460440903018857. PMC 2882713. PMID 20544003.
Shanks KG, Behonick GS, Dahn T, Terrell A (October 2013). "Identification of novel third-generation synthetic cannabinoids in products by ultra-performance liquid chromatography and time-of-flight mass spectrometry". Journal of Analytical Toxicology. 37 (8): 517–525. doi:10.1093/jat/bkt062. PMID 23946450.
Uchiyama N, Matsuda S, Kawamura M, Shimokawa Y, Kikura-Hanajiri R, Aritake K, et al. (October 2014). "Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products". Forensic Science International. 243: 1–13. doi:10.1016/j.forsciint.2014.03.013. PMID 24769262.

ncbi.nlm.nih.gov

Otrubova K, Ezzili C, Boger DL (August 2011). "The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)". Bioorganic & Medicinal Chemistry Letters. 21 (16): 4674–4685. doi:10.1016/j.bmcl.2011.06.096. PMC 3146581. PMID 21764305.
Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, et al. (June 2014). "Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain". ACS Medicinal Chemistry Letters. 5 (6): 717–721. doi:10.1021/ml5001239. PMC 4060928. PMID 24944750.
Ahn K, Johnson DS, Cravatt BF (July 2009). "Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders". Expert Opinion on Drug Discovery. 4 (7): 763–784. doi:10.1517/17460440903018857. PMC 2882713. PMID 20544003.

ouest-france.fr

Benotame L, Clero O (19 January 2016). "Essai clinique: le patient décédé était un artiste". L'Edition du Soir Ouest France. Retrieved 6 February 2016.
"Essai thérapeutique à Rennes. Une mort cérébrale, cinq hospitalisés". Ouest-France. 15 January 2016. Retrieved 24 January 2016.
"Essai thérapeutique. Que dit la loi?". Ouest-France. 15 January 2016. Retrieved 27 January 2016.

publico.pt

Cunha Freitas A (5 July 2016). "Bial vai lançar medicamento para Parkinson no final do Verão". Público (Portugal). Retrieved 18 May 2018.

raps.org

"EMA Will Assess ANSM Review of Botched Clinical Trial in France". RAPS Regulatory Affairs Professional Society. 19 January 2016. Retrieved 24 January 2016.

reuters.com

Blamont M (January 15, 2016). "French drug trial disaster leaves one brain dead, five injured". Reuters. Retrieved January 16, 2016.
Blamont M (15 January 2016). "French drug trial disaster leaves one brain dead, five injured". Reuters. Retrieved 24 January 2016.

sante.fr

ansm.sante.fr

"La survenue d'effets graves ayant entraîné l'hospitalisation de 6 patients, dont un en état de mort cérébrale, a conduit à l'arrêt prématuré d'un essai clinique du laboratoire BIAL - Point d'information". Agence Nationale de Sécurité du Médicament, France (ANSM). 15 January 2016. Archived from the original on 2016-01-18. Retrieved 2016-01-16.
"Essai clinique de Rennes - Rapport final du CSST " inhibiteurs de la FAAH "". Agence Nationale de Sécurité du Médicament et des Produits de Santé(ANSM). 19 April 2016. Archived from the original on 2016-05-30. Retrieved 22 May 2016.
"Clinical Study Protocol N° BIA-102474-101 (Version 1.2, 1 July 2015)" (PDF). 1 July 2015. Retrieved 22 Jan 2016 – via ANSM.
"Version anglaise : Minutes of the Temporary Specialist Scientific Committee (TSSC) meeting on "FAAH (Fatty Acid Amide Hydrolase) Inhibitors" of 15/02/2016 (08/03/2016)". Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). 7 March 2016. Archived from the original on 12 March 2016. Retrieved 10 March 2016.
"Essai clinique BIA-102474-101 du laboratoire BIAL : Publication du protocole clinique" (in French). Agence Nationale de Sécurité du Médicament et des Produits de Santé. 22 Jan 2016. Archived from the original on 2016-01-31. Retrieved 2016-01-25.
"Essai clinique BIA-102474-101- Bial/Biotrial : Chronologie". Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). Archived from the original on 2016-01-28. Retrieved 2016-01-28.
"CSST Examens des données cliniques et d'imagerie cérébrale des volontaires sains inclus dans l'essai mené avec le BIA 10-2474 et conduit à Rennes". Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). 25 November 2016. Archived from the original on 19 May 2018. Retrieved 18 May 2018.

science.org

Feldwisch-Drentrup H (8 June 2017). "New clues to why a French drug trial went horribly wrong". Science. Retrieved 18 May 2018.
Enserink M (16 January 2016). "More details emerge on fateful French drug trial". Science Magazine. Retrieved 18 January 2016.
Enserink M (16 January 2016). "More Details Emerge on Fateful French Drug Trial". Science. Retrieved 16 January 2016.
Enserink M (23 May 2016). "France tightens rules in wake of fatal clinical trial". Science. Retrieved 18 May 2018.
Feldwisch-Drentrup H (25 July 2016). "Europe overhauls rules for 'first-in-human' trials in wake of French disaster". Science. doi:10.1126/science.aag0686. Retrieved 19 October 2016.

sciencemediacentre.org

"Expert reaction to French drug trial - reports of one patient dying and five others in hospital and of the Paris prosecutor's office having opened an investigation into what happened". Science Media Centre, London. 16 January 2016. Retrieved 21 January 2016.

semanticscholar.org

api.semanticscholar.org

Bisogno T, Maccarrone M (May 2013). "Latest advances in the discovery of fatty acid amide hydrolase inhibitors". Expert Opinion on Drug Discovery. 8 (5): 509–522. doi:10.1517/17460441.2013.780021. PMID 23488865. S2CID 33195822.
Casassus B (23 January 2016). "France investigates drug trial disaster" (PDF). The Lancet. 387 (10016): 326. doi:10.1016/S0140-6736(16)00154-9. PMID 26842439. S2CID 31310363.
Callaway E, Butler D (22 January 2016). "Researchers question design of fatal French clinical trial". Nature News. doi:10.1038/nature.2016.19221. S2CID 181956785.
Casassus B (February 2016). "France releases interim report on drug trial disaster". Lancet. 387 (10019): 634–635. doi:10.1016/S0140-6736(16)00318-4. PMID 26876704. S2CID 39093208.
Randerson J (22 December 2016). "Fatal French clinical trial failed to check data before raising drug dose". Nature. doi:10.1038/nature.2016.21190. S2CID 78424247. Retrieved 18 May 2018.

"Accident grave dans le cadre d'un essai clinique - Intervention de Marisol Touraine à Rennes". Ministère des Affaires Sociales, de la Santé et des Droits des Femmes, France. 15 January 2016. Archived from the original on 20 January 2016. Retrieved 17 January 2016.
"NOTE D'ETAPE : ENQUETE SUR DES INCIDENTS GRAVES SURVENUS DANS LE CADRE DE LA REALISATION D'UN ESSAI CLINIQUE" (PDF). Inspection générale des affaires sociales. February 2016. Retrieved 5 February 2016.
"Intervention de Marisol Touraine - Conférence de presse - Accident d'essai clinique – point d'étape". Ministère des Affaires Sociales, de la Santé et des Droits des Femmes, France. 4 February 2016. Retrieved 5 February 2016.

spiegel.de

"Todesfall bei Medikamententest: Ministerin wirft Institut Biotrial Fehler vor" (in German). Der Spiegel. February 4, 2016. Retrieved February 4, 2016.

statslife.org.uk

"RSS issues statement regarding tragic 'first-in-man' clinical trial". Royal Statistical Society. 26 January 2016. Retrieved 28 January 2016.

theguardian.com

"French drug trial leaves one brain dead and five critically ill". The Guardian. 15 January 2016. Retrieved 24 January 2016.
Agence France-Presse (18 January 2016). "Man dies in Rennes hospital after drug trial left him brain dead". The Guardian. Retrieved 19 January 2016.
AFP Paris (8 March 2016). "Man who died in French drug trial had 'unprecedented' reaction, say experts". The Guardian Online. Retrieved 15 March 2016.

thelancet.com

Casassus B (23 January 2016). "France investigates drug trial disaster" (PDF). The Lancet. 387 (10016): 326. doi:10.1016/S0140-6736(16)00154-9. PMID 26842439. S2CID 31310363.

web.archive.org

"News Release - Phase I Clinical Trial Rennes". www.bial.com. Archived from the original on 22 January 2016. Retrieved 21 January 2016.
"La survenue d'effets graves ayant entraîné l'hospitalisation de 6 patients, dont un en état de mort cérébrale, a conduit à l'arrêt prématuré d'un essai clinique du laboratoire BIAL - Point d'information". Agence Nationale de Sécurité du Médicament, France (ANSM). 15 January 2016. Archived from the original on 2016-01-18. Retrieved 2016-01-16.
"Accident grave dans le cadre d'un essai clinique - Intervention de Marisol Touraine à Rennes". Ministère des Affaires Sociales, de la Santé et des Droits des Femmes, France. 15 January 2016. Archived from the original on 20 January 2016. Retrieved 17 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°2 concernant les patients hospitalisés au CHU et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 17 January 2016. Archived from the original (PDF) on 3 February 2016. Retrieved 18 January 2016.
"Essai clinique de Rennes - Rapport final du CSST " inhibiteurs de la FAAH "". Agence Nationale de Sécurité du Médicament et des Produits de Santé(ANSM). 19 April 2016. Archived from the original on 2016-05-30. Retrieved 22 May 2016.
"Version anglaise : Minutes of the Temporary Specialist Scientific Committee (TSSC) meeting on "FAAH (Fatty Acid Amide Hydrolase) Inhibitors" of 15/02/2016 (08/03/2016)". Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). 7 March 2016. Archived from the original on 12 March 2016. Retrieved 10 March 2016.
"Essai clinique BIA-102474-101 du laboratoire BIAL : Publication du protocole clinique" (in French). Agence Nationale de Sécurité du Médicament et des Produits de Santé. 22 Jan 2016. Archived from the original on 2016-01-31. Retrieved 2016-01-25.
"PRESS RELEASE - IGAS Status Report: Clarifications from Biotrial". www.biotrial.com. 5 February 2016. Archived from the original on 6 February 2016. Retrieved 6 February 2016.
"Message from Biotrial". www.biotrial.com. 15 January 2016. Archived from the original on 2016-06-28. Retrieved 17 January 2016.
"Communication from Biotrial February 5th, 2016". www.biotrial.com. 5 February 2016. Archived from the original on 26 February 2016. Retrieved 6 February 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°4 concernant les patients hospitalisés au CHU de Rennes et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 19 January 2016. Archived from the original (PDF) on 22 January 2016. Retrieved 25 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°5 concernant les patients hospitalisés au CHU de Rennes et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 20 January 2016. Archived from the original (PDF) on 3 February 2016. Retrieved 21 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°7 concernant les patients hospitalisés dans des structures proches de leur domicile et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 26 January 2016. Archived from the original (PDF) on 5 February 2016. Retrieved 27 January 2016.
"COMMUNIQUE DE PRESSE: Point de situation n°6 concernant les patients hospitalisés au CHU de Rennes et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 21 January 2016. Archived from the original (PDF) on 3 February 2016. Retrieved 25 January 2016.
"CSST Examens des données cliniques et d'imagerie cérébrale des volontaires sains inclus dans l'essai mené avec le BIA 10-2474 et conduit à Rennes". Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM). 25 November 2016. Archived from the original on 19 May 2018. Retrieved 18 May 2018.
"COMMUNIQUE DE PRESSE: Point de situation n°3 concernant les patients hospitalisés au CHU et les personnes volontaires incluses dans l'essai clinique réalisé par le centre de recherche privé Biotrial pour le compte de la société Bial" (PDF). University Hospital Rennes. 18 January 2016. Archived from the original (PDF) on 22 January 2016. Retrieved 24 January 2016.
"Merck Pipeline, Oct 2009" (PDF). Merck. 15 October 2009. Archived from the original (PDF) on 20 October 2016. Retrieved 15 January 2016.
"Janssen Research & Development, LLC Voluntarily Suspends Dosing in Phase 2 Clinical Trials of Experimental Treatment for Mood Disorders". Janssen.com. 17 January 2016. Archived from the original on 2016-01-25. Retrieved 21 January 2016.

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"Clinical Study Protocol N° BIA-102474-101 (Version 2.0, 16 October 2015)". Le Figaro. 21 January 2016. Retrieved 23 January 2016.