Bruce Beutler (English Wikipedia)

Hildebrandt, Sabine; Kammertöns, Thomas; Lechner, Christian; Schmitt, Philipp; Schumann, Ralf R. (2019). "Dr. Käthe Beutler, 1896–1999". Medizinhistorisches Journal. 54 (4): 294–346. doi:10.25162/mhj-2019-0009. ISSN 0025-8431. S2CID 213008951.

biopharmadive.com

Gardner, Jonathan (November 1, 2021). "A three-decade monopoly: how Amgen built a patent thicket around its top-selling drug | BioPharma Dive". BioPharma Dive. Retrieved March 9, 2023.

biorxiv.org

Lazar, Daniel C.; Wang, Wesley W.; Chiu, Tzu-Yuan; Li, Weichao; Jadhav, Appaso M.; Wozniak, Jacob M.; Gazaniga, Nathalia; Theofilopoulos, Argyrios N.; Teijaro, John R.; Parker, Christopher G. (October 7, 2022), Chemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity, doi:10.1101/2022.10.07.511216, S2CID 252820006

catanzaroinforma.it

"Umg, laurea honoris causa al Premio Nobel Bruce Alan Beutler". September 23, 2019.

delmartimes.net

Eric (April 24, 2009). "TSRI's Beutler shares America's largest prize in medicine". Del Mar Times. Retrieved March 9, 2023.

doi.org

Poltorak, A.; He, X.; Smirnova, I.; Liu, M. Y.; Van Huffel, C.; Du, X.; Birdwell, D.; Alejos, E.; Silva, M.; Galanos, C.; Freudenberg, M.; Ricciardi-Castagnoli, P.; Layton, B.; Beutler, B. (December 11, 1998). "Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene". Science. 282 (5396): 2085–2088. doi:10.1126/science.282.5396.2085. ISSN 0036-8075. PMID 9851930.
Hemmi, Hiroaki; Kaisho, Tsuneyasu; Takeuchi, Osamu; Sato, Shintaro; Sanjo, Hideki; Hoshino, Katsuaki; Horiuchi, Takao; Tomizawa, Hideyuki; Takeda, Kiyoshi; Akira, Shizuo (January 22, 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nature Immunology. 3 (2): 196–200. doi:10.1038/ni758. ISSN 1529-2908. PMID 11812998. S2CID 1694900.
Hemmi, H.; Takeuchi, O.; Kawai, T.; Kaisho, T.; Sato, S.; Sanjo, H.; Matsumoto, M.; Hoshino, K.; Wagner, H.; Takeda, K.; Akira, S. (December 7, 2000). "A Toll-like receptor recognizes bacterial DNA". Nature. 408 (6813): 740–745. Bibcode:2000Natur.408..740H. doi:10.1038/35047123. ISSN 0028-0836. PMID 11130078. S2CID 4405163.
Takeuchi, O.; Hoshino, K.; Kawai, T.; Sanjo, H.; Takada, H.; Ogawa, T.; Takeda, K.; Akira, S. (October 1, 1999). "Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components". Immunity. 11 (4): 443–451. doi:10.1016/s1074-7613(00)80119-3. ISSN 1074-7613. PMID 10549626.
Takeuchi, O.; Kawai, T.; Mühlradt, P. F.; Morr, M.; Radolf, J. D.; Zychlinsky, A.; Takeda, K.; Akira, S. (July 1, 2001). "Discrimination of bacterial lipoproteins by Toll-like receptor 6". International Immunology. 13 (7): 933–940. doi:10.1093/intimm/13.7.933. ISSN 0953-8178. PMID 11431423.
Takeuchi, Osamu; Sato, Shintaro; Horiuchi, Takao; Hoshino, Katsuaki; Takeda, Kiyoshi; Dong, Zhongyun; Modlin, Robert L.; Akira, Shizuo (July 1, 2002). "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". Journal of Immunology. 169 (1): 10–14. doi:10.4049/jimmunol.169.1.10. ISSN 0022-1767. PMID 12077222. S2CID 22686400.
Ravindran, S. (2013). "Profile of Bruce A. Beutler". Proceedings of the National Academy of Sciences. 110 (32): 12857–8. Bibcode:2013PNAS..11012857R. doi:10.1073/pnas.1311624110. PMC 3740904. PMID 23858464.
Beutler, E.; West, C.; Beutler, B. (October 1974). "Electrophoretic polymorphism of glutathione peroxidase". Annals of Human Genetics. 38 (2): 163–169. doi:10.1111/j.1469-1809.1974.tb01947.x. ISSN 0003-4800. PMID 4467780. S2CID 32294741.
Beutler, E.; Beutler, B.; Matsumoto, J. (July 15, 1975). "Glutathione peroxidase activity of inorganic selenium and seleno-DL-cysteine". Experientia. 31 (7): 769–770. doi:10.1007/BF01938453. ISSN 0014-4754. PMID 1140308. S2CID 26234261.
Ohno, S. (January 1977). "The original function of MHC antigens as the general plasma membrane anchorage site of organogenesis-directing proteins". Immunological Reviews. 33: 59–69. doi:10.1111/j.1600-065X.1977.tb00362.x. ISSN 0105-2896. PMID 66186. S2CID 45992817.
Beutler, B.; Nagai, Y.; Ohno, S.; Klein, G.; Shapiro, I. M. (March 1978). "The HLA-dependent expression of testis- organizing H-Y antigen by human male cells". Cell. 13 (3): 509–513. doi:10.1016/0092-8674(78)90324-0. ISSN 0092-8674. PMID 77737. S2CID 33827976.
Beutler, B.; Greenwald, D.; Hulmes, J. D.; Chang, M.; Pan, Y. C.; Mathison, J.; Ulevitch, R.; Cerami, A. (August 1, 1985). "Identity of tumour necrosis factor and the macrophage-secreted factor cachectin". Nature. 316 (6028): 552–554. Bibcode:1985Natur.316..552B. doi:10.1038/316552a0. ISSN 0028-0836. PMID 2993897. S2CID 4339006.
Beutler, B.; Mahoney, J.; Le Trang, N.; Pekala, P.; Cerami, A. (May 1, 1985). "Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells". The Journal of Experimental Medicine. 161 (5): 984–995. doi:10.1084/jem.161.5.984. ISSN 0022-1007. PMC 2187615. PMID 3872925.
Aggarwal, B. B.; Kohr, W. J.; Hass, P. E.; Moffat, B.; Spencer, S. A.; Henzel, W. J.; Bringman, T. S.; Nedwin, G. E.; Goeddel, D. V.; Harkins, R. N. (February 25, 1985). "Human tumor necrosis factor. Production, purification, and characterization". The Journal of Biological Chemistry. 260 (4): 2345–2354. doi:10.1016/S0021-9258(18)89560-6. ISSN 0021-9258. PMID 3871770.
Beutler, B.; Milsark, I. W.; Cerami, A. C. (August 30, 1985). "Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin". Science. 229 (4716): 869–871. Bibcode:1985Sci...229..869B. doi:10.1126/science.3895437. ISSN 0036-8075. PMID 3895437.
Dayer, J. M.; Beutler, B.; Cerami, A. (December 1, 1985). "Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts". The Journal of Experimental Medicine. 162 (6): 2163–2168. doi:10.1084/jem.162.6.2163. ISSN 0022-1007. PMC 2187983. PMID 2999289.
Feldmann, M.; Brennan, F. M.; Maini, R. N. (1996). "Role of cytokines in rheumatoid arthritis". Annual Review of Immunology. 14: 397–440. doi:10.1146/annurev.immunol.14.1.397. ISSN 0732-0582. PMID 8717520.
Engelmann, H.; Novick, D.; Wallach, D. (January 25, 1990). "Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors". The Journal of Biological Chemistry. 265 (3): 1531–1536. doi:10.1016/S0021-9258(19)40049-5. ISSN 0021-9258. PMID 2153136.
Loetscher, H.; Pan, Y. C.; Lahm, H. W.; Gentz, R.; Brockhaus, M.; Tabuchi, H.; Lesslauer, W. (April 20, 1990). "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor". Cell. 61 (2): 351–359. doi:10.1016/0092-8674(90)90815-v. ISSN 0092-8674. PMID 2158862. S2CID 42245440.
Nophar, Y.; Kemper, O.; Brakebusch, C.; Englemann, H.; Zwang, R.; Aderka, D.; Holtmann, H.; Wallach, D. (October 1, 1990). "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor". The EMBO Journal. 9 (10): 3269–3278. doi:10.1002/j.1460-2075.1990.tb07526.x. ISSN 0261-4189. PMC 552060. PMID 1698610.
Schall, T. J.; Lewis, M.; Koller, K. J.; Lee, A.; Rice, G. C.; Wong, G. H.; Gatanaga, T.; Granger, G. A.; Lentz, R.; Raab, H. (April 20, 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell. 61 (2): 361–370. doi:10.1016/0092-8674(90)90816-w. ISSN 0092-8674. PMID 2158863. S2CID 36187863.
Smith, C. A.; Davis, T.; Anderson, D.; Solam, L.; Beckmann, M. P.; Jerzy, R.; Dower, S. K.; Cosman, D.; Goodwin, R. G. (May 25, 1990). "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins". Science. 248 (4958): 1019–1023. Bibcode:1990Sci...248.1019S. doi:10.1126/science.2160731. ISSN 0036-8075. PMID 2160731.
Poltorak, A.; Peppel, K.; Beutler, B. (February 28, 1994). "Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations". Journal of Immunological Methods. 169 (1): 93–99. doi:10.1016/0022-1759(94)90128-7. ISSN 0022-1759. PMID 8133076.
Peppel, K.; Crawford, D.; Beutler, B. (December 1, 1991). "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity". The Journal of Experimental Medicine. 174 (6): 1483–1489. doi:10.1084/jem.174.6.1483. ISSN 0022-1007. PMC 2119031. PMID 1660525.
Beutler, B.; Poltorak, A. (July 2001). "Sepsis and evolution of the innate immune response". Critical Care Medicine. 29 (7 Suppl): S2–6, discussion S6–7. doi:10.1097/00003246-200107001-00002. ISSN 0090-3493. PMID 11445725.
Johnson, A. G.; Gaines, S.; Landy, M. (February 1, 1956). "Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide". The Journal of Experimental Medicine. 103 (2): 225–246. doi:10.1084/jem.103.2.225. ISSN 0022-1007. PMC 2136584. PMID 13286429.
Coutinho, A.; Meo, T. (December 1978). "Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice". Immunogenetics. 7 (1): 17–24. doi:10.1007/BF01843983. ISSN 0093-7711. PMID 21302052. S2CID 29425605.
Watson, J.; Riblet, R. (November 1, 1974). "Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic respones [sic] to lipopolysaccharides". The Journal of Experimental Medicine. 140 (5): 1147–1161. doi:10.1084/jem.140.5.1147. ISSN 0022-1007. PMC 2139714. PMID 4138849.
Sultzer, B. M. (September 21, 1968). "Genetic control of leucocyte responses to endotoxin". Nature. 219 (5160): 1253–1254. Bibcode:1968Natur.219.1253S. doi:10.1038/2191253a0. ISSN 0028-0836. PMID 4877918. S2CID 41633552.
Beutler, Bruce (January 2002). "Toll-like receptors: how they work and what they do". Current Opinion in Hematology. 9 (1): 2–10. doi:10.1097/00062752-200201000-00002. ISSN 1065-6251. PMID 11753071. S2CID 36843541.
Du, X.; Poltorak, A.; Silva, M.; Beutler, B. (1999). "Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor". Blood Cells, Molecules & Diseases. 25 (5–6): 328–338. doi:10.1006/bcmd.1999.0262. ISSN 1079-9796. PMID 10660480.
Poltorak, A.; Ricciardi-Castagnoli, P.; Citterio, S.; Beutler, B. (February 29, 2000). "Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2163–2167. Bibcode:2000PNAS...97.2163P. doi:10.1073/pnas.040565397. ISSN 0027-8424. PMC 15771. PMID 10681462.
Shimazu, R.; Akashi, S.; Ogata, H.; Nagai, Y.; Fukudome, K.; Miyake, K.; Kimoto, M. (June 7, 1999). "MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4". The Journal of Experimental Medicine. 189 (11): 1777–1782. doi:10.1084/jem.189.11.1777. ISSN 0022-1007. PMC 2193086. PMID 10359581.
Park, Beom Seok; Song, Dong Hyun; Kim, Ho Min; Choi, Byong-Seok; Lee, Hayyoung; Lee, Jie-Oh (April 30, 2009). "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex". Nature. 458 (7242): 1191–1195. Bibcode:2009Natur.458.1191P. doi:10.1038/nature07830. ISSN 1476-4687. PMID 19252480. S2CID 4396446.
Lemaitre, B.; Nicolas, E.; Michaut, L.; Reichhart, J. M.; Hoffmann, J. A. (September 20, 1996). "The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults". Cell. 86 (6): 973–983. doi:10.1016/s0092-8674(00)80172-5. ISSN 0092-8674. PMID 8808632. S2CID 10736743.
Medzhitov, R.; Preston-Hurlburt, P.; Janeway, C. A. (July 24, 1997). "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity". Nature. 388 (6640): 394–397. doi:10.1038/41131. ISSN 0028-0836. PMID 9237759. S2CID 4311321.
Kirschning, C. J.; Wesche, H.; Merrill Ayres, T.; Rothe, M. (December 7, 1998). "Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide". The Journal of Experimental Medicine. 188 (11): 2091–2097. doi:10.1084/jem.188.11.2091. ISSN 0022-1007. PMC 2212382. PMID 9841923.
Yang, R. B.; Mark, M. R.; Gray, A.; Huang, A.; Xie, M. H.; Zhang, M.; Goddard, A.; Wood, W. I.; Gurney, A. L.; Godowski, P. J. (September 17, 1998). "Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling". Nature. 395 (6699): 284–288. Bibcode:1998Natur.395..284Y. doi:10.1038/26239. ISSN 0028-0836. PMID 9751057. S2CID 4422827.
Christensen, Sean R.; Shupe, Jonathan; Nickerson, Kevin; Kashgarian, Michael; Flavell, Richard A.; Shlomchik, Mark J. (September 2006). "Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus". Immunity. 25 (3): 417–428. doi:10.1016/j.immuni.2006.07.013. ISSN 1074-7613. PMID 16973389.
Brown, Grant J.; Cañete, Pablo F.; Wang, Hao; Medhavy, Arti; Bones, Josiah; Roco, Jonathan A.; He, Yuke; Qin, Yuting; Cappello, Jean; Ellyard, Julia I.; Bassett, Katharine; Shen, Qian; Burgio, Gaetan; Zhang, Yaoyuan; Turnbull, Cynthia (May 2022). "TLR7 gain-of-function genetic variation causes human lupus". Nature. 605 (7909): 349–356. Bibcode:2022Natur.605..349B. doi:10.1038/s41586-022-04642-z. ISSN 1476-4687. PMC 9095492. PMID 35477763.
Leibler, Claire; John, Shinu; Elsner, Rebecca A.; Thomas, Kayla B.; Smita, Shuchi; Joachim, Stephen; Levack, Russell C.; Callahan, Derrick J.; Gordon, Rachael A.; Bastacky, Sheldon; Fukui, Ryutaro; Miyake, Kensuke; Gingras, Sebastien; Nickerson, Kevin M.; Shlomchik, Mark J. (October 2022). "Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus". Nature Immunology. 23 (10): 1457–1469. doi:10.1038/s41590-022-01310-2. ISSN 1529-2916. PMC 9561083. PMID 36151396.
Baccala, Roberto; Gonzalez-Quintial, Rosana; Blasius, Amanda L.; Rimann, Ivo; Ozato, Keiko; Kono, Dwight H.; Beutler, Bruce; Theofilopoulos, Argyrios N. (February 19, 2013). "Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus". Proceedings of the National Academy of Sciences of the United States of America. 110 (8): 2940–2945. Bibcode:2013PNAS..110.2940B. doi:10.1073/pnas.1222798110. ISSN 1091-6490. PMC 3581947. PMID 23382217.
Kono, Dwight H.; Haraldsson, M. Katarina; Lawson, Brian R.; Pollard, K. Michael; Koh, Yi Ting; Du, Xin; Arnold, Carrie N.; Baccala, Roberto; Silverman, Gregg J.; Beutler, Bruce A.; Theofilopoulos, Argyrios N. (July 21, 2009). "Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus". Proceedings of the National Academy of Sciences of the United States of America. 106 (29): 12061–12066. Bibcode:2009PNAS..10612061K. doi:10.1073/pnas.0905441106. ISSN 1091-6490. PMC 2715524. PMID 19574451.
Lau, Christina M.; Broughton, Courtney; Tabor, Abigail S.; Akira, Shizuo; Flavell, Richard A.; Mamula, Mark J.; Christensen, Sean R.; Shlomchik, Mark J.; Viglianti, Gregory A.; Rifkin, Ian R.; Marshak-Rothstein, Ann (November 7, 2005). "RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement". The Journal of Experimental Medicine. 202 (9): 1171–1177. doi:10.1084/jem.20050630. ISSN 0022-1007. PMC 2213226. PMID 16260486.
Leadbetter, Elizabeth A.; Rifkin, Ian R.; Hohlbaum, Andreas M.; Beaudette, Britte C.; Shlomchik, Mark J.; Marshak-Rothstein, Ann (April 11, 2002). "Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors". Nature. 416 (6881): 603–607. doi:10.1038/416603a. ISSN 0028-0836. PMID 11948342. S2CID 4370544.
Viglianti, Gregory A.; Lau, Christina M.; Hanley, Timothy M.; Miko, Benjamin A.; Shlomchik, Mark J.; Marshak-Rothstein, Ann (December 2003). "Activation of autoreactive B cells by CpG dsDNA". Immunity. 19 (6): 837–847. doi:10.1016/s1074-7613(03)00323-6. ISSN 1074-7613. PMID 14670301.
Beutler, Bruce; Du, Xin; Xia, Yu (July 2007). "Precis on forward genetics in mice". Nature Immunology. 8 (7): 659–664. doi:10.1038/ni0707-659. ISSN 1529-2908. PMID 17579639. S2CID 28309476.
Hoebe, K.; Du, X.; Georgel, P.; Janssen, E.; Tabeta, K.; Kim, S. O.; Goode, J.; Lin, P.; Mann, N.; Mudd, S.; Crozat, K.; Sovath, S.; Han, J.; Beutler, B. (August 14, 2003). "Identification of Lps2 as a key transducer of MyD88-independent TIR signalling". Nature. 424 (6950): 743–748. Bibcode:2003Natur.424..743H. doi:10.1038/nature01889. ISSN 1476-4687. PMID 12872135. S2CID 15608748.
Hoebe, Kasper; Georgel, Philippe; Rutschmann, Sophie; Du, Xin; Mudd, Suzanne; Crozat, Karine; Sovath, Sosathya; Shamel, Louis; Hartung, Thomas; Zähringer, Ulrich; Beutler, Bruce (February 3, 2005). "CD36 is a sensor of diacylglycerides". Nature. 433 (7025): 523–527. Bibcode:2005Natur.433..523H. doi:10.1038/nature03253. ISSN 1476-4687. PMID 15690042. S2CID 4406318.
Tabeta, Koichi; Hoebe, Kasper; Janssen, Edith M.; Du, Xin; Georgel, Philippe; Crozat, Karine; Mudd, Suzanne; Mann, Navjiwan; Sovath, Sosathya; Goode, Jason; Shamel, Louis; Herskovits, Anat A.; Portnoy, Daniel A.; Cooke, Michael; Tarantino, Lisa M. (January 15, 2006). "The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9". Nature Immunology. 7 (2): 156–164. doi:10.1038/ni1297. ISSN 1529-2908. PMID 16415873. S2CID 33401155.
Croker, Ben A.; Lawson, Brian R.; Rutschmann, Sophie; Berger, Michael; Eidenschenk, Celine; Blasius, Amanda L.; Moresco, Eva Marie Y.; Sovath, Sosathya; Cengia, Louise; Shultz, Leonard D.; Theofilopoulos, Argyrios N.; Pettersson, Sven; Beutler, Bruce Alan (September 30, 2008). "Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger". Proceedings of the National Academy of Sciences of the United States of America. 105 (39): 15028–15033. Bibcode:2008PNAS..10515028C. doi:10.1073/pnas.0806619105. ISSN 1091-6490. PMC 2567487. PMID 18806225.
Shi, Hexin; Wang, Ying; Li, Xiaohong; Zhan, Xiaoming; Tang, Miao; Fina, Maggy; Su, Lijing; Pratt, David; Bu, Chun Hui; Hildebrand, Sara; Lyon, Stephen; Scott, Lindsay; Quan, Jiexia; Sun, Qihua; Russell, Jamie (December 7, 2015). "NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component". Nature Immunology. 17 (3): 250–258. doi:10.1038/ni.3333. ISSN 1529-2916. PMC 4862588. PMID 26642356.
Sun, Lei; Jiang, Zhengfan; Acosta-Rodriguez, Victoria A.; Berger, Michael; Du, Xin; Choi, Jin Huk; Wang, Jianhui; Wang, Kuan-Wen; Kilaru, Gokhul K.; Mohawk, Jennifer A.; Quan, Jiexia; Scott, Lindsay; Hildebrand, Sara; Li, Xiaohong; Tang, Miao (November 6, 2017). "HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections". The Journal of Experimental Medicine. 214 (11): 3263–3277. doi:10.1084/jem.20161630. ISSN 1540-9538. PMC 5679162. PMID 28970238.
Shi, Hexin; Sun, Lei; Wang, Ying; Liu, Aijie; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Hildebrand, Sara; Quan, Jiexia; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (March 2, 2021). "N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization". Nature Communications. 12 (1): 1379. Bibcode:2021NatCo..12.1379S. doi:10.1038/s41467-021-21711-5. ISSN 2041-1723. PMC 7925594. PMID 33654074.
Kim, You-Me; Brinkmann, Melanie M.; Paquet, Marie-Eve; Ploegh, Hidde L. (March 13, 2008). "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes". Nature. 452 (7184): 234–238. Bibcode:2008Natur.452..234K. doi:10.1038/nature06726. ISSN 1476-4687. PMID 18305481. S2CID 4397023.
Casrouge, Armanda; Zhang, Shen-Ying; Eidenschenk, Céline; Jouanguy, Emmanuelle; Puel, Anne; Yang, Kun; Alcais, Alexandre; Picard, Capucine; Mahfoufi, Nora; Nicolas, Nathalie; Lorenzo, Lazaro; Plancoulaine, Sabine; Sénéchal, Brigitte; Geissmann, Frédéric; Tabeta, Koichi (October 13, 2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797): 308–312. Bibcode:2006Sci...314..308C. doi:10.1126/science.1128346. ISSN 1095-9203. PMID 16973841. S2CID 12501759.
Blasius, Amanda L.; Arnold, Carrie N.; Georgel, Philippe; Rutschmann, Sophie; Xia, Yu; Lin, Pei; Ross, Charles; Li, Xiaohong; Smart, Nora G.; Beutler, Bruce (November 16, 2010). "Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19973–19978. Bibcode:2010PNAS..10719973B. doi:10.1073/pnas.1014051107. ISSN 1091-6490. PMC 2993408. PMID 21045126.
Lazar, Daniel C.; Wang, Wesley W.; Chiu, Tzu-Yuan; Li, Weichao; Jadhav, Appaso M.; Wozniak, Jacob M.; Gazaniga, Nathalia; Theofilopoulos, Argyrios N.; Teijaro, John R.; Parker, Christopher G. (October 7, 2022), Chemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity, doi:10.1101/2022.10.07.511216, S2CID 252820006
Beutler, Bruce; Crozat, Karine; Koziol, James A.; Georgel, Philippe (February 2005). "Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model". Current Opinion in Immunology. 17 (1): 36–43. doi:10.1016/j.coi.2004.11.004. ISSN 0952-7915. PMID 15653308.
Beutler, Bruce; Eidenschenk, Celine; Crozat, Karine; Imler, Jean-Luc; Takeuchi, Osamu; Hoffmann, Jules A.; Akira, Shizuo (October 2007). "Genetic analysis of resistance to viral infection". Nature Reviews. Immunology. 7 (10): 753–766. doi:10.1038/nri2174. ISSN 1474-1741. PMID 17893693. S2CID 37705652.
Croker, B.; Crozat, K.; Berger, M.; Xia, Y.; Sovath, S.; Schaffer, L.; Eleftherianos, I.; Imler, J. L.; Beutler, B. (2007). "ATP-sensitive potassium channels mediate survival during infection in mammals and insects". Nature Genetics. 39 (12): 1453–1460. doi:10.1038/ng.2007.25. PMID 18026101. S2CID 41183715.
Brandl, Katharina; Rutschmann, Sophie; Li, Xiaohong; Du, Xin; Xiao, Nengming; Schnabl, Bernd; Brenner, David A.; Beutler, Bruce (March 3, 2009). "Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3300–3305. Bibcode:2009PNAS..106.3300B. doi:10.1073/pnas.0813036106. ISSN 1091-6490. PMC 2651297. PMID 19202076.
Brandl, Katharina; Sun, Lei; Neppl, Christina; Siggs, Owen M.; Le Gall, Sylvain M.; Tomisato, Wataru; Li, Xiaohong; Du, Xin; Maennel, Daniela N.; Blobel, Carl P.; Beutler, Bruce (November 16, 2010). "MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19967–19972. Bibcode:2010PNAS..10719967B. doi:10.1073/pnas.1014669107. ISSN 1091-6490. PMC 2993336. PMID 21041656.
Brandl, Katharina; Tomisato, Wataru; Li, Xiaohong; Neppl, Christina; Pirie, Elaine; Falk, Werner; Xia, Yu; Moresco, Eva Marie Y.; Baccala, Roberto; Theofilopoulos, Argyrios N.; Schnabl, Bernd; Beutler, Bruce (July 31, 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12650–12655. Bibcode:2012PNAS..10912650B. doi:10.1073/pnas.1210366109. ISSN 1091-6490. PMC 3412000. PMID 22802641.
McAlpine, William; Sun, Lei; Wang, Kuan-Wen; Liu, Aijie; Jain, Ruchi; San Miguel, Miguel; Wang, Jianhui; Zhang, Zhao; Hayse, Braden; McAlpine, Sarah Grace; Choi, Jin Huk; Zhong, Xue; Ludwig, Sara; Russell, Jamie; Zhan, Xiaoming (December 4, 2018). "Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function". Proceedings of the National Academy of Sciences of the United States of America. 115 (49): E11523 – E11531. Bibcode:2018PNAS..11511523M. doi:10.1073/pnas.1814753115. ISSN 1091-6490. PMC 6298088. PMID 30442666.
McAlpine, William; Wang, Kuan-Wen; Choi, Jin Huk; San Miguel, Miguel; McAlpine, Sarah Grace; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao; Bu, Chun Hui; Murray, Anne R.; Moresco, Eva Marie Y. (September 27, 2018). "The class I myosin MYO1D binds to lipid and protects against colitis". Disease Models & Mechanisms. 11 (9): dmm035923. doi:10.1242/dmm.035923. ISSN 1754-8411. PMC 6176994. PMID 30279225.
Wang, Kuan-Wen; Zhan, Xiaoming; McAlpine, William; Zhang, Zhao; Choi, Jin Huk; Shi, Hexin; Misawa, Takuma; Yue, Tao; Zhang, Duanwu; Wang, Ying; Ludwig, Sara; Russell, Jamie; Tang, Miao; Li, Xiaohong; Murray, Anne R. (June 4, 2019). "Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice". Proceedings of the National Academy of Sciences of the United States of America. 116 (23): 11380–11389. Bibcode:2019PNAS..11611380W. doi:10.1073/pnas.1901407116. ISSN 1091-6490. PMC 6561264. PMID 31097594.
Turer, Emre; McAlpine, William; Wang, Kuan-Wen; Lu, Tianshi; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Murray, Anne R.; Beutler, Bruce (February 14, 2017). "Creatine maintains intestinal homeostasis and protects against colitis". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1273 – E1281. Bibcode:2017PNAS..114E1273T. doi:10.1073/pnas.1621400114. ISSN 1091-6490. PMC 5321020. PMID 28137860.
SoRelle, Jeffrey A.; Chen, Zhe; Wang, Jianhui; Yue, Tao; Choi, Jin Huk; Wang, Kuan-Wen; Zhong, Xue; Hildebrand, Sara; Russell, Jamie; Scott, Lindsay; Xu, Darui; Zhan, Xiaowei; Bu, Chun Hui; Wang, Tao; Choi, Mihwa (April 2021). "Dominant atopy risk mutations identified by mouse forward genetic analysis". Allergy. 76 (4): 1095–1108. doi:10.1111/all.14564. ISSN 1398-9995. PMC 7889751. PMID 32810290.
Chatenoud, Lucienne; Marquet, Cindy; Valette, Fabrice; Scott, Lindsay; Quan, Jiexia; Bu, Chun Hui; Hildebrand, Sara; Moresco, Eva Marie Y.; Bach, Jean-François; Beutler, Bruce (June 1, 2022). "Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice". Disease Models & Mechanisms. 15 (6): dmm049484. doi:10.1242/dmm.049484. ISSN 1754-8411. PMC 9178510. PMID 35502705.
Foray, Anne-Perrine; Candon, Sophie; Hildebrand, Sara; Marquet, Cindy; Valette, Fabrice; Pecquet, Coralie; Lemoine, Sebastien; Langa-Vives, Francina; Dumas, Michael; Hu, Peipei; Santamaria, Pere; You, Sylvaine; Lyon, Stephen; Scott, Lindsay; Bu, Chun Hui (November 23, 2021). "De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes". Proceedings of the National Academy of Sciences of the United States of America. 118 (47): e2112032118. Bibcode:2021PNAS..11812032F. doi:10.1073/pnas.2112032118. ISSN 1091-6490. PMC 8617500. PMID 34782469.
Zhang, Zhao; Turer, Emre; Li, Xiaohong; Zhan, Xiaoming; Choi, Mihwa; Tang, Miao; Press, Amanda; Smith, Steven R.; Divoux, Adeline; Moresco, Eva Marie Y.; Beutler, Bruce (October 18, 2016). "Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice". Proceedings of the National Academy of Sciences of the United States of America. 113 (42): E6418 – E6426. Bibcode:2016PNAS..113E6418Z. doi:10.1073/pnas.1614467113. ISSN 1091-6490. PMC 5081616. PMID 27708159.
Turer, Emre E.; San Miguel, Miguel; Wang, Kuan-Wen; McAlpine, William; Ou, Feiya; Li, Xiaohong; Tang, Miao; Zang, Zhao; Wang, Jianhui; Hayse, Braden; Evers, Bret; Zhan, Xiaoming; Russell, Jamie; Beutler, Bruce (December 18, 2018). "A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis". Disease Models & Mechanisms. 11 (12): dmm035451. doi:10.1242/dmm.035451. ISSN 1754-8411. PMC 6307907. PMID 30563851.
Zhang, Zhao; Jiang, Yiao; Su, Lijing; Ludwig, Sara; Zhang, Xuechun; Tang, Miao; Li, Xiaohong; Anderton, Priscilla; Zhan, Xiaoming; Choi, Mihwa; Russell, Jamie; Bu, Chun-Hui; Lyon, Stephen; Xu, Darui; Hildebrand, Sara (November 1, 2022). "Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis". Cell Metabolism. 34 (11): 1860–1874.e4. doi:10.1016/j.cmet.2022.09.018. ISSN 1932-7420. PMC 9633419. PMID 36228616.
Berger, Michael; Krebs, Philippe; Crozat, Karine; Li, Xiaohong; Croker, Ben A.; Siggs, Owen M.; Popkin, Daniel; Du, Xin; Lawson, Brian R.; Theofilopoulos, Argyrios N.; Xia, Yu; Khovananth, Kevin; Moresco, Eva Marie; Satoh, Takashi; Takeuchi, Osamu (April 2010). "An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence". Nature Immunology. 11 (4): 335–343. doi:10.1038/ni.1847. ISSN 1529-2916. PMC 2861894. PMID 20190759.
Siggs, Owen M.; Arnold, Carrie N.; Huber, Christoph; Pirie, Elaine; Xia, Yu; Lin, Pei; Nemazee, David; Beutler, Bruce (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–440. doi:10.1038/ni.2012. ISSN 1529-2916. PMC 3079768. PMID 21423172.
Siggs, Owen M.; Li, Xiaohong; Xia, Yu; Beutler, Bruce (January 16, 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. ISSN 1540-9538. PMC 3260866. PMID 22201126.
Choi, Jin Huk; Han, Jonghee; Theodoropoulos, Panayotis C.; Zhong, Xue; Wang, Jianhui; Medler, Dawson; Ludwig, Sara; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Gallagher, Thomas; Yu, Gang; Beutler, Bruce (March 3, 2020). "Essential requirement for nicastrin in marginal zone and B-1 B cell development". Proceedings of the National Academy of Sciences of the United States of America. 117 (9): 4894–4901. Bibcode:2020PNAS..117.4894C. doi:10.1073/pnas.1916645117. ISSN 1091-6490. PMC 7060662. PMID 32071239.
Choi, Jin Huk; Zhong, Xue; McAlpine, William; Liao, Tzu-Chieh; Zhang, Duanwu; Fang, Beibei; Russell, Jamie; Ludwig, Sara; Nair-Gill, Evan; Zhang, Zhao; Wang, Kuan-Wen; Misawa, Takuma; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao (May 10, 2019). "LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling". Science. 364 (6440): eaau0812. doi:10.1126/science.aau0812. ISSN 1095-9203. PMC 7206793. PMID 31073040.
Choi, Jin Huk; Zhong, Xue; Zhang, Zhao; Su, Lijing; McAlpine, William; Misawa, Takuma; Liao, Tzu-Chieh; Zhan, Xiaoming; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Moresco, Eva Marie Y.; Beutler, Bruce (April 6, 2020). "Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development". The Journal of Experimental Medicine. 217 (4): e20190006. doi:10.1084/jem.20190006. ISSN 1540-9538. PMC 7144532. PMID 31985756.
Zhang, Duanwu; Yue, Tao; Choi, Jin Huk; Nair-Gill, Evan; Zhong, Xue; Wang, Kuan-Wen; Zhan, Xiaoming; Li, Xiaohong; Choi, Mihwa; Tang, Miao; Quan, Jiexia; Hildebrand, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (October 2019). "Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40". Nature Immunology. 20 (10): 1322–1334. doi:10.1038/s41590-019-0464-4. ISSN 1529-2916. PMC 7179765. PMID 31427773.
Zhong, Xue; Choi, Jin Huk; Hildebrand, Sara; Ludwig, Sara; Wang, Jianhui; Nair-Gill, Evan; Liao, Tzu-Chieh; Moresco, James J.; Liu, Aijie; Quan, Jiexia; Sun, Qihua; Zhang, Duanwu; Zhan, Xiaoming; Choi, Mihwa; Li, Xiaohong (May 3, 2022). "RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice". Proceedings of the National Academy of Sciences of the United States of America. 119 (18): e2200128119. Bibcode:2022PNAS..11900128Z. doi:10.1073/pnas.2200128119. ISSN 1091-6490. PMC 9170173. PMID 35482923.
Zhong, Xue; Su, Lijing; Yang, Yi; Nair-Gill, Evan; Tang, Miao; Anderton, Priscilla; Li, Xiaohong; Wang, Jianhui; Zhan, Xiaoming; Tomchick, Diana R.; Brautigam, Chad A.; Moresco, Eva Marie Y.; Choi, Jin Huk; Beutler, Bruce (April 14, 2020). "Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function". Proceedings of the National Academy of Sciences of the United States of America. 117 (15): 8563–8572. Bibcode:2020PNAS..117.8563Z. doi:10.1073/pnas.2000703117. ISSN 1091-6490. PMC 7165429. PMID 32220963.
Misawa, Takuma; SoRelle, Jeffrey A.; Choi, Jin Huk; Yue, Tao; Wang, Kuan-Wen; McAlpine, William; Wang, Jianhui; Liu, Aijie; Tabeta, Koichi; Turer, Emre E.; Evers, Bret; Nair-Gill, Evan; Poddar, Subhajit; Su, Lijing; Ou, Feiya (January 24, 2020). "Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation". Science Immunology. 5 (43): eaaz0085. doi:10.1126/sciimmunol.aaz0085. ISSN 2470-9468. PMC 7278039. PMID 31980486.
Arnold, Carrie N.; Pirie, Elaine; Dosenovic, Pia; McInerney, Gerald M.; Xia, Yu; Wang, Nathaniel; Li, Xiaohong; Siggs, Owen M.; Karlsson Hedestam, Gunilla B.; Beutler, Bruce (July 31, 2012). "A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12286–12293. doi:10.1073/pnas.1209134109. ISSN 1091-6490. PMC 3411946. PMID 22761313.
Choi, Jin Huk; Wang, Kuan-Wen; Zhang, Duanwu; Zhan, Xiaowei; Wang, Tao; Bu, Chun-Hui; Behrendt, Cassie L.; Zeng, Ming; Wang, Ying; Misawa, Takuma; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Scott, Lindsay; Hildebrand, Sara (February 14, 2017). "IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1196 – E1204. Bibcode:2017PNAS..114E1196C. doi:10.1073/pnas.1621258114. ISSN 1091-6490. PMC 5321007. PMID 28137874.
Yue, Tao; Zhan, Xiaoming; Zhang, Duanwu; Jain, Ruchi; Wang, Kuan-Wen; Choi, Jin Huk; Misawa, Takuma; Su, Lijing; Quan, Jiexia; Hildebrand, Sara; Xu, Darui; Li, Xiaohong; Turer, Emre; Sun, Lei; Moresco, Eva Marie Y. (May 14, 2021). "SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity". Science. 372 (6543): eaba4220. doi:10.1126/science.aba4220. ISSN 1095-9203. PMC 8442736. PMID 33986151.
Nair-Gill, Evan; Bonora, Massimo; Zhong, Xue; Liu, Aijie; Miranda, Amber; Stewart, Nathan; Ludwig, Sara; Russell, Jamie; Gallagher, Thomas; Pinton, Paolo; Beutler, Bruce (May 3, 2021). "Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases". The EMBO Journal. 40 (9): e104888. doi:10.15252/embj.2020104888. ISSN 1460-2075. PMC 8090855. PMID 33630350.
Du, X.; She, E.; Gelbart, T.; Truksa, J.; Lee, P.; Xia, Y.; Khovananth, K.; Mudd, S.; Mann, N.; Moresco, E. M. Y.; Beutler, E.; Beutler, B. (2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. PMC 2430097. PMID 18451267.
Du, X.; Schwander, M.; Moresco, E. M. Y.; Viviani, P.; Haller, C.; Hildebrand, M. S.; Pak, K.; Tarantino, L.; Roberts, A.; Richardson, H.; Koob, G.; Najmabadi, H.; Ryan, A. F.; Smith, R. J. H.; Muller, U.; Beutler, B. (2008). "A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy of Sciences. 105 (38): 14609–14614. Bibcode:2008PNAS..10514609D. doi:10.1073/pnas.0807219105. PMC 2567147. PMID 18794526.
Blasius, Amanda L.; Brandl, Katharina; Crozat, Karine; Xia, Yu; Khovananth, Kevin; Krebs, Philippe; Smart, Nora G.; Zampolli, Antonella; Ruggeri, Zaverio M.; Beutler, Bruce A. (February 24, 2009). "Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2706–2711. Bibcode:2009PNAS..106.2706B. doi:10.1073/pnas.0813208106. ISSN 1091-6490. PMC 2650330. PMID 19202056.
Rutschmann, Sophie; Crozat, Karine; Li, Xiaohong; Du, Xin; Hanselman, Jeffrey C.; Shigeoka, Alana A.; Brandl, Katharina; Popkin, Daniel L.; McKay, Dianne B.; Xia, Yu; Moresco, Eva Marie Y.; Beutler, Bruce (April 2012). "Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice". G3: Genes, Genomes, Genetics. 2 (4): 499–504. doi:10.1534/g3.112.002196. ISSN 2160-1836. PMC 3337478. PMID 22540041.
Chen, Zhe; Holland, William; Shelton, John M.; Ali, Aktar; Zhan, Xiaoming; Won, Sungyong; Tomisato, Wataru; Liu, Chen; Li, Xiaohong; Moresco, Eva Marie Y.; Beutler, Bruce (May 20, 2014). "Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 111 (20): 7367–7372. Bibcode:2014PNAS..111.7367C. doi:10.1073/pnas.1406511111. ISSN 1091-6490. PMC 4034201. PMID 24799716.
Zhang, Zhao; Gallagher, Thomas; Scherer, Philipp E.; Beutler, Bruce (May 26, 2020). "Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome". Proceedings of the National Academy of Sciences of the United States of America. 117 (21): 11829–11835. Bibcode:2020PNAS..11711829Z. doi:10.1073/pnas.2000118117. ISSN 1091-6490. PMC 7260979. PMID 32381739.
Zhang, Zhao; Xun, Yu; Rong, Shunxing; Yan, Lijuan; SoRelle, Jeffrey A.; Li, Xiaohong; Tang, Miao; Keller, Katie; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (July 16, 2022). "Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity". Nature Communications. 13 (1): 4136. Bibcode:2022NatCo..13.4136Z. doi:10.1038/s41467-022-31812-4. ISSN 2041-1723. PMC 9288484. PMID 35842425.
Smyth, Ian; Du, Xin; Taylor, Martin S.; Justice, Monica J.; Beutler, Bruce; Jackson, Ian J. (September 14, 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13560–13565. Bibcode:2004PNAS..10113560S. doi:10.1073/pnas.0402760101. ISSN 0027-8424. PMC 518794. PMID 15345741.
Al-Fadhli, Fatima M.; Afqi, Manal; Sairafi, Mona Hamza; Almuntashri, Makki; Alharby, Essa; Alharbi, Ghadeer; Abdud Samad, Firoz; Hashmi, Jamil Amjad; Zaytuni, Dimah; Bahashwan, Ahmed A.; Choi, Jin Huk; Peake, Roy W. A.; Beutler, Bruce; Almontashiri, Naif A. M. (May 2021). "Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes". Clinical Genetics. 99 (5): 694–703. doi:10.1111/cge.13930. ISSN 1399-0004. PMID 33495992. S2CID 231710148.
Israel, Laura; Wang, Ying; Bulek, Katarzyna; Della Mina, Erika; Zhang, Zhao; Pedergnana, Vincent; Chrabieh, Maya; Lemmens, Nicole A.; Sancho-Shimizu, Vanessa; Descatoire, Marc; Lasseau, Théo; Israelsson, Elisabeth; Lorenzo, Lazaro; Yun, Ling; Belkadi, Aziz (February 23, 2017). "Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity". Cell. 168 (5): 789–800.e10. doi:10.1016/j.cell.2017.01.039. ISSN 1097-4172. PMC 5328639. PMID 28235196.
Melis, Maria Antonietta; Cau, Milena; Congiu, Rita; Sole, Gabriella; Barella, Susanna; Cao, Antonio; Westerman, Mark; Cazzola, Mario; Galanello, Renzo (October 2008). "A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron". Haematologica. 93 (10): 1473–1479. doi:10.3324/haematol.13342. ISSN 1592-8721. PMID 18603562. S2CID 23364362.
El Hayek, Lauretta; Tuncay, Islam Oguz; Nijem, Nadine; Russell, Jamie; Ludwig, Sara; Kaur, Kiran; Li, Xiaohong; Anderton, Priscilla; Tang, Miao; Gerard, Amanda; Heinze, Anja; Zacher, Pia; Alsaif, Hessa S.; Rad, Aboulfazl; Hassanpour, Kazem (December 22, 2020). "KDM5A mutations identified in autism spectrum disorder using forward genetics". eLife. 9: e56883. doi:10.7554/eLife.56883. ISSN 2050-084X. PMC 7755391. PMID 33350388.
Rios, Jonathan J.; Denton, Kristin; Yu, Hao; Manickam, Kandamurugu; Garner, Shannon; Russell, Jamie; Ludwig, Sara; Rosenfeld, Jill A.; Liu, Pengfei; Munch, Jake; Sucato, Daniel J.; Beutler, Bruce; Wise, Carol A. (June 1, 2021). "Saturation mutagenesis defines novel mouse models of severe spine deformity". Disease Models & Mechanisms. 14 (6): dmm048901. doi:10.1242/dmm.048901. ISSN 1754-8411. PMC 8246263. PMID 34142127.
Rios, Jonathan J.; Denton, Kristin; Russell, Jamie; Kozlitina, Julia; Ferreira, Carlos R.; Lewanda, Amy F.; Mayfield, Joshua E.; Moresco, Eva; Ludwig, Sara; Tang, Miao; Li, Xiaohong; Lyon, Stephen; Khanshour, Anas; Paria, Nandina; Khalid, Aysha (August 2021). "Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice". Journal of Bone and Mineral Research. 36 (8): 1548–1565. doi:10.1002/jbmr.4323. ISSN 1523-4681. PMC 8862308. PMID 33905568.
Andrews, T. D.; Whittle, B.; Field, M. A.; Balakishnan, B.; Zhang, Y.; Shao, Y.; Cho, V.; Kirk, M.; Singh, M.; Xia, Y.; Hager, J.; Winslade, S.; Sjollema, G.; Beutler, B.; Enders, A. (May 2012). "Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models". Open Biology. 2 (5): 120061. doi:10.1098/rsob.120061. ISSN 2046-2441. PMC 3376740. PMID 22724066.
Bull, Katherine R.; Rimmer, Andrew J.; Siggs, Owen M.; Miosge, Lisa A.; Roots, Carla M.; Enders, Anselm; Bertram, Edward M.; Crockford, Tanya L.; Whittle, Belinda; Potter, Paul K.; Simon, Michelle M.; Mallon, Ann-Marie; Brown, Steve D. M.; Beutler, Bruce; Goodnow, Christopher C. (2013). "Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations". PLOS Genetics. 9 (1): e1003219. doi:10.1371/journal.pgen.1003219. ISSN 1553-7404. PMC 3561070. PMID 23382690.
Xia, Yu; Won, Sungyong; Du, Xin; Lin, Pei; Ross, Charles; La Vine, Diantha; Wiltshire, Sean; Leiva, Gabriel; Vidal, Silvia M.; Whittle, Belinda; Goodnow, Christopher C.; Koziol, James; Moresco, Eva Marie Y.; Beutler, Bruce (December 2010). "Bulk segregation mapping of mutations in closely related strains of mice". Genetics. 186 (4): 1139–1146. doi:10.1534/genetics.110.121160. ISSN 1943-2631. PMC 2998299. PMID 20923982.
Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Lyon, Stephen; Pratt, David; Hildebrand, Sara; Choi, Jin Huk; Zhang, Zhao; Zeng, Ming; Wang, Kuan-wen; Turer, Emre; Chen, Zhe; Zhang, Duanwu; Yue, Tao; Wang, Ying (February 3, 2015). "Real-time resolution of point mutations that cause phenovariance in mice". Proceedings of the National Academy of Sciences of the United States of America. 112 (5): E440–449. Bibcode:2015PNAS..112E.440W. doi:10.1073/pnas.1423216112. ISSN 1091-6490. PMC 4321302. PMID 25605905.
Wang, Tao; Bu, Chun Hui; Hildebrand, Sara; Jia, Gaoxiang; Siggs, Owen M.; Lyon, Stephen; Pratt, David; Scott, Lindsay; Russell, Jamie; Ludwig, Sara; Murray, Anne R.; Moresco, Eva Marie Y.; Beutler, Bruce (January 30, 2018). "Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database". Nature Communications. 9 (1): 441. Bibcode:2018NatCo...9..441W. doi:10.1038/s41467-017-02806-4. ISSN 2041-1723. PMC 5789985. PMID 29382827.
Xu, Darui; Lyon, Stephen; Bu, Chun Hui; Hildebrand, Sara; Choi, Jin Huk; Zhong, Xue; Liu, Aijie; Turer, Emre E.; Zhang, Zhao; Russell, Jamie; Ludwig, Sara; Mahrt, Elena; Nair-Gill, Evan; Shi, Hexin; Wang, Ying (July 13, 2021). "Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning". Proceedings of the National Academy of Sciences of the United States of America. 118 (28): e2106786118. Bibcode:2021PNAS..11806786X. doi:10.1073/pnas.2106786118. ISSN 1091-6490. PMC 8285956. PMID 34260399.
Chen, Bo; Aredo, Bogale; Ding, Yi; Zhong, Xin; Zhu, Yuanfei; Zhao, Cynthia X.; Kumar, Ashwani; Xing, Chao; Gautron, Laurent; Lyon, Stephen; Russell, Jamie; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Ludwig, Sara (June 9, 2020). "Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 12931–12942. Bibcode:2020PNAS..11712931C. doi:10.1073/pnas.1921224117. ISSN 1091-6490. PMC 7293615. PMID 32457148.
Wang, Yibing; Cao, Liqin; Lee, Chia-Ying; Matsuo, Tomohiko; Wu, Kejia; Asher, Greg; Tang, Lijun; Saitoh, Tsuyoshi; Russell, Jamie; Klewe-Nebenius, Daniela; Wang, Li; Soya, Shingo; Hasegawa, Emi; Chérasse, Yoan; Zhou, Jiamin (May 23, 2018). "Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors". Nature Communications. 9 (1): 2041. Bibcode:2018NatCo...9.2041W. doi:10.1038/s41467-018-04324-3. ISSN 2041-1723. PMC 5966455. PMID 29795268.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Mifune, Yuto; Su, Lijing; Shi, Hexin; Moresco, Eva Marie Y.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (October 31, 2018). "Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists". Journal of the American Chemical Society. 140 (43): 14440–14454. doi:10.1021/jacs.8b09223. ISSN 1520-5126. PMC 6209530. PMID 30272974.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Su, Lijing; Surakattula, Murali M. R. P.; Berger, Michael; Huang, Hua; Beutler, Elliot K.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (May 26, 2016). "Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists". Journal of Medicinal Chemistry. 59 (10): 4812–4830. doi:10.1021/acs.jmedchem.6b00177. ISSN 1520-4804. PMC 4882283. PMID 27050713.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Mifune, Yuto; Shi, Hexin; Wang, Kuan-Wen; Zhan, Xiaoming; Liu, Aijie; Wang, Jianhui; Li, Xiaohong; Tang, Miao; Ludwig, Sara; Hildebrand, Sara; Zhou, Kejin (September 11, 2018). "Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice". Proceedings of the National Academy of Sciences of the United States of America. 115 (37): E8698 – E8706. Bibcode:2018PNAS..115E8698W. doi:10.1073/pnas.1809232115. ISSN 1091-6490. PMC 6140543. PMID 30150374.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Whitby, Landon R.; Surakattula, Murali M. R. P.; Huang, Hua; Shi, Hexin; Choi, Jin Huk; Wang, Kuan-wen; Moresco, Eva Marie Y.; Berger, Michael; Zhan, Xiaoming; Zhang, Hong; Boger, Dale L. (February 16, 2016). "TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS". Proceedings of the National Academy of Sciences of the United States of America. 113 (7): E884–893. Bibcode:2016PNAS..113E.884W. doi:10.1073/pnas.1525639113. ISSN 1091-6490. PMC 4763747. PMID 26831104.
Su, Lijing; Athamna, Muhammad; Wang, Ying; Wang, Junmei; Freudenberg, Marina; Yue, Tao; Wang, Jianhui; Moresco, Eva Marie Y.; He, Haoming; Zor, Tsaffrir; Beutler, Bruce (July 27, 2021). "Sulfatides are endogenous ligands for the TLR4-MD-2 complex". Proceedings of the National Academy of Sciences of the United States of America. 118 (30): e2105316118. Bibcode:2021PNAS..11805316S. doi:10.1073/pnas.2105316118. ISSN 1091-6490. PMC 8325290. PMID 34290146.
Su, Lijing; Wang, Ying; Wang, Junmei; Mifune, Yuto; Morin, Matthew D.; Jones, Brian T.; Moresco, Eva Marie Y.; Boger, Dale L.; Beutler, Bruce; Zhang, Hong (March 28, 2019). "Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim". Journal of Medicinal Chemistry. 62 (6): 2938–2949. doi:10.1021/acs.jmedchem.8b01583. ISSN 1520-4804. PMC 6537610. PMID 30829478.
Yang, Ming-Hsiu; Russell, Jamie L.; Mifune, Yuto; Wang, Ying; Shi, Hexin; Moresco, Eva Marie Y.; Siegwart, Daniel J.; Beutler, Bruce; Boger, Dale L. (July 14, 2022). "Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response". Journal of Medicinal Chemistry. 65 (13): 9230–9252. doi:10.1021/acs.jmedchem.2c00419. ISSN 1520-4804. PMC 9283309. PMID 35767437.
Beutler, Bruce (January 1, 2009). "Ernest Beutler (1928–2008)". Haematologica. 94 (1): 154–156. doi:10.3324/haematol.13863. ISSN 1592-8721. PMC 2625414. PMID 19118377. S2CID 43531611.
Beutler, E. (February 1959). "The hemolytic effect of primaquine and related compounds: a review". Blood. 14 (2): 103–139. doi:10.1182/blood.V14.2.103.103. ISSN 0006-4971. PMID 13618370.
Beutler, E (February 1961). "Hematology: Iron Metabolism". Annual Review of Medicine. 12 (1): 195–210. doi:10.1146/annurev.me.12.020161.001211. ISSN 0066-4219.
Beutler, Ernest (July 2006). "Lysosomal storage diseases: natural history and ethical and economic aspects". Molecular Genetics and Metabolism. 88 (3): 208–215. doi:10.1016/j.ymgme.2006.01.010. ISSN 1096-7192. PMID 16515872.
Piro, L. D.; Carrera, C. J.; Carson, D. A.; Beutler, E. (April 19, 1990). "Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine". The New England Journal of Medicine. 322 (16): 1117–1121. doi:10.1056/NEJM199004193221605. ISSN 0028-4793. PMID 1969613.
Beutler, E.; Yeh, M.; Fairbanks, V. F. (January 15, 1962). "The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker". Proceedings of the National Academy of Sciences of the United States of America. 48 (1): 9–16. Bibcode:1962PNAS...48....9B. doi:10.1073/pnas.48.1.9. ISSN 0027-8424. PMC 285481. PMID 13868717.
Beutler, Bruce; Beutler, Ernest (December 12, 2002). "Toll-like receptor 4 polymorphisms and atherogenesis". The New England Journal of Medicine. 347 (24): 1978–1980, author reply 1978–1980. doi:10.1056/NEJM200212123472416. ISSN 1533-4406. PMID 12479194.
Beutler, E.; Gelbart, T.; Han, J. H.; Koziol, J. A.; Beutler, B. (January 1989). "Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage". Proceedings of the National Academy of Sciences of the United States of America. 86 (1): 192–196. Bibcode:1989PNAS...86..192B. doi:10.1073/pnas.86.1.192. ISSN 0027-8424. PMC 286430. PMID 2463621.
Truksa, Jaroslav; Gelbart, Terri; Peng, Hongfan; Beutler, Ernest; Beutler, Bruce; Lee, Pauline (November 2009). "Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6". British Journal of Haematology. 147 (4): 571–581. doi:10.1111/j.1365-2141.2009.07873.x. ISSN 1365-2141. PMID 19751239. S2CID 205266224.
Du, Xin; She, Ellen; Gelbart, Terri; Truksa, Jaroslav; Lee, Pauline; Xia, Yu; Khovananth, Kevin; Mudd, Suzanne; Mann, Navjiwan; Moresco, Eva Marie Y.; Beutler, Ernest; Beutler, Bruce (May 23, 2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. ISSN 1095-9203. PMC 2430097. PMID 18451267.
Hildebrandt, Sabine; Kammertöns, Thomas; Lechner, Christian; Schmitt, Philipp; Schumann, Ralf R. (2019). "Dr. Käthe Beutler, 1896–1999". Medizinhistorisches Journal. 54 (4): 294–346. doi:10.25162/mhj-2019-0009. ISSN 0025-8431. S2CID 213008951.

harvard.edu

ui.adsabs.harvard.edu

Hemmi, H.; Takeuchi, O.; Kawai, T.; Kaisho, T.; Sato, S.; Sanjo, H.; Matsumoto, M.; Hoshino, K.; Wagner, H.; Takeda, K.; Akira, S. (December 7, 2000). "A Toll-like receptor recognizes bacterial DNA". Nature. 408 (6813): 740–745. Bibcode:2000Natur.408..740H. doi:10.1038/35047123. ISSN 0028-0836. PMID 11130078. S2CID 4405163.
Ravindran, S. (2013). "Profile of Bruce A. Beutler". Proceedings of the National Academy of Sciences. 110 (32): 12857–8. Bibcode:2013PNAS..11012857R. doi:10.1073/pnas.1311624110. PMC 3740904. PMID 23858464.
Beutler, B.; Greenwald, D.; Hulmes, J. D.; Chang, M.; Pan, Y. C.; Mathison, J.; Ulevitch, R.; Cerami, A. (August 1, 1985). "Identity of tumour necrosis factor and the macrophage-secreted factor cachectin". Nature. 316 (6028): 552–554. Bibcode:1985Natur.316..552B. doi:10.1038/316552a0. ISSN 0028-0836. PMID 2993897. S2CID 4339006.
Beutler, B.; Milsark, I. W.; Cerami, A. C. (August 30, 1985). "Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin". Science. 229 (4716): 869–871. Bibcode:1985Sci...229..869B. doi:10.1126/science.3895437. ISSN 0036-8075. PMID 3895437.
Smith, C. A.; Davis, T.; Anderson, D.; Solam, L.; Beckmann, M. P.; Jerzy, R.; Dower, S. K.; Cosman, D.; Goodwin, R. G. (May 25, 1990). "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins". Science. 248 (4958): 1019–1023. Bibcode:1990Sci...248.1019S. doi:10.1126/science.2160731. ISSN 0036-8075. PMID 2160731.
Sultzer, B. M. (September 21, 1968). "Genetic control of leucocyte responses to endotoxin". Nature. 219 (5160): 1253–1254. Bibcode:1968Natur.219.1253S. doi:10.1038/2191253a0. ISSN 0028-0836. PMID 4877918. S2CID 41633552.
Poltorak, A.; Ricciardi-Castagnoli, P.; Citterio, S.; Beutler, B. (February 29, 2000). "Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2163–2167. Bibcode:2000PNAS...97.2163P. doi:10.1073/pnas.040565397. ISSN 0027-8424. PMC 15771. PMID 10681462.
Park, Beom Seok; Song, Dong Hyun; Kim, Ho Min; Choi, Byong-Seok; Lee, Hayyoung; Lee, Jie-Oh (April 30, 2009). "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex". Nature. 458 (7242): 1191–1195. Bibcode:2009Natur.458.1191P. doi:10.1038/nature07830. ISSN 1476-4687. PMID 19252480. S2CID 4396446.
Yang, R. B.; Mark, M. R.; Gray, A.; Huang, A.; Xie, M. H.; Zhang, M.; Goddard, A.; Wood, W. I.; Gurney, A. L.; Godowski, P. J. (September 17, 1998). "Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling". Nature. 395 (6699): 284–288. Bibcode:1998Natur.395..284Y. doi:10.1038/26239. ISSN 0028-0836. PMID 9751057. S2CID 4422827.
Brown, Grant J.; Cañete, Pablo F.; Wang, Hao; Medhavy, Arti; Bones, Josiah; Roco, Jonathan A.; He, Yuke; Qin, Yuting; Cappello, Jean; Ellyard, Julia I.; Bassett, Katharine; Shen, Qian; Burgio, Gaetan; Zhang, Yaoyuan; Turnbull, Cynthia (May 2022). "TLR7 gain-of-function genetic variation causes human lupus". Nature. 605 (7909): 349–356. Bibcode:2022Natur.605..349B. doi:10.1038/s41586-022-04642-z. ISSN 1476-4687. PMC 9095492. PMID 35477763.
Baccala, Roberto; Gonzalez-Quintial, Rosana; Blasius, Amanda L.; Rimann, Ivo; Ozato, Keiko; Kono, Dwight H.; Beutler, Bruce; Theofilopoulos, Argyrios N. (February 19, 2013). "Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus". Proceedings of the National Academy of Sciences of the United States of America. 110 (8): 2940–2945. Bibcode:2013PNAS..110.2940B. doi:10.1073/pnas.1222798110. ISSN 1091-6490. PMC 3581947. PMID 23382217.
Kono, Dwight H.; Haraldsson, M. Katarina; Lawson, Brian R.; Pollard, K. Michael; Koh, Yi Ting; Du, Xin; Arnold, Carrie N.; Baccala, Roberto; Silverman, Gregg J.; Beutler, Bruce A.; Theofilopoulos, Argyrios N. (July 21, 2009). "Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus". Proceedings of the National Academy of Sciences of the United States of America. 106 (29): 12061–12066. Bibcode:2009PNAS..10612061K. doi:10.1073/pnas.0905441106. ISSN 1091-6490. PMC 2715524. PMID 19574451.
Hoebe, K.; Du, X.; Georgel, P.; Janssen, E.; Tabeta, K.; Kim, S. O.; Goode, J.; Lin, P.; Mann, N.; Mudd, S.; Crozat, K.; Sovath, S.; Han, J.; Beutler, B. (August 14, 2003). "Identification of Lps2 as a key transducer of MyD88-independent TIR signalling". Nature. 424 (6950): 743–748. Bibcode:2003Natur.424..743H. doi:10.1038/nature01889. ISSN 1476-4687. PMID 12872135. S2CID 15608748.
Hoebe, Kasper; Georgel, Philippe; Rutschmann, Sophie; Du, Xin; Mudd, Suzanne; Crozat, Karine; Sovath, Sosathya; Shamel, Louis; Hartung, Thomas; Zähringer, Ulrich; Beutler, Bruce (February 3, 2005). "CD36 is a sensor of diacylglycerides". Nature. 433 (7025): 523–527. Bibcode:2005Natur.433..523H. doi:10.1038/nature03253. ISSN 1476-4687. PMID 15690042. S2CID 4406318.
Croker, Ben A.; Lawson, Brian R.; Rutschmann, Sophie; Berger, Michael; Eidenschenk, Celine; Blasius, Amanda L.; Moresco, Eva Marie Y.; Sovath, Sosathya; Cengia, Louise; Shultz, Leonard D.; Theofilopoulos, Argyrios N.; Pettersson, Sven; Beutler, Bruce Alan (September 30, 2008). "Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger". Proceedings of the National Academy of Sciences of the United States of America. 105 (39): 15028–15033. Bibcode:2008PNAS..10515028C. doi:10.1073/pnas.0806619105. ISSN 1091-6490. PMC 2567487. PMID 18806225.
Shi, Hexin; Sun, Lei; Wang, Ying; Liu, Aijie; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Hildebrand, Sara; Quan, Jiexia; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (March 2, 2021). "N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization". Nature Communications. 12 (1): 1379. Bibcode:2021NatCo..12.1379S. doi:10.1038/s41467-021-21711-5. ISSN 2041-1723. PMC 7925594. PMID 33654074.
Kim, You-Me; Brinkmann, Melanie M.; Paquet, Marie-Eve; Ploegh, Hidde L. (March 13, 2008). "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes". Nature. 452 (7184): 234–238. Bibcode:2008Natur.452..234K. doi:10.1038/nature06726. ISSN 1476-4687. PMID 18305481. S2CID 4397023.
Casrouge, Armanda; Zhang, Shen-Ying; Eidenschenk, Céline; Jouanguy, Emmanuelle; Puel, Anne; Yang, Kun; Alcais, Alexandre; Picard, Capucine; Mahfoufi, Nora; Nicolas, Nathalie; Lorenzo, Lazaro; Plancoulaine, Sabine; Sénéchal, Brigitte; Geissmann, Frédéric; Tabeta, Koichi (October 13, 2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797): 308–312. Bibcode:2006Sci...314..308C. doi:10.1126/science.1128346. ISSN 1095-9203. PMID 16973841. S2CID 12501759.
Blasius, Amanda L.; Arnold, Carrie N.; Georgel, Philippe; Rutschmann, Sophie; Xia, Yu; Lin, Pei; Ross, Charles; Li, Xiaohong; Smart, Nora G.; Beutler, Bruce (November 16, 2010). "Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19973–19978. Bibcode:2010PNAS..10719973B. doi:10.1073/pnas.1014051107. ISSN 1091-6490. PMC 2993408. PMID 21045126.
Brandl, Katharina; Rutschmann, Sophie; Li, Xiaohong; Du, Xin; Xiao, Nengming; Schnabl, Bernd; Brenner, David A.; Beutler, Bruce (March 3, 2009). "Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3300–3305. Bibcode:2009PNAS..106.3300B. doi:10.1073/pnas.0813036106. ISSN 1091-6490. PMC 2651297. PMID 19202076.
Brandl, Katharina; Sun, Lei; Neppl, Christina; Siggs, Owen M.; Le Gall, Sylvain M.; Tomisato, Wataru; Li, Xiaohong; Du, Xin; Maennel, Daniela N.; Blobel, Carl P.; Beutler, Bruce (November 16, 2010). "MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19967–19972. Bibcode:2010PNAS..10719967B. doi:10.1073/pnas.1014669107. ISSN 1091-6490. PMC 2993336. PMID 21041656.
Brandl, Katharina; Tomisato, Wataru; Li, Xiaohong; Neppl, Christina; Pirie, Elaine; Falk, Werner; Xia, Yu; Moresco, Eva Marie Y.; Baccala, Roberto; Theofilopoulos, Argyrios N.; Schnabl, Bernd; Beutler, Bruce (July 31, 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12650–12655. Bibcode:2012PNAS..10912650B. doi:10.1073/pnas.1210366109. ISSN 1091-6490. PMC 3412000. PMID 22802641.
McAlpine, William; Sun, Lei; Wang, Kuan-Wen; Liu, Aijie; Jain, Ruchi; San Miguel, Miguel; Wang, Jianhui; Zhang, Zhao; Hayse, Braden; McAlpine, Sarah Grace; Choi, Jin Huk; Zhong, Xue; Ludwig, Sara; Russell, Jamie; Zhan, Xiaoming (December 4, 2018). "Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function". Proceedings of the National Academy of Sciences of the United States of America. 115 (49): E11523 – E11531. Bibcode:2018PNAS..11511523M. doi:10.1073/pnas.1814753115. ISSN 1091-6490. PMC 6298088. PMID 30442666.
Wang, Kuan-Wen; Zhan, Xiaoming; McAlpine, William; Zhang, Zhao; Choi, Jin Huk; Shi, Hexin; Misawa, Takuma; Yue, Tao; Zhang, Duanwu; Wang, Ying; Ludwig, Sara; Russell, Jamie; Tang, Miao; Li, Xiaohong; Murray, Anne R. (June 4, 2019). "Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice". Proceedings of the National Academy of Sciences of the United States of America. 116 (23): 11380–11389. Bibcode:2019PNAS..11611380W. doi:10.1073/pnas.1901407116. ISSN 1091-6490. PMC 6561264. PMID 31097594.
Turer, Emre; McAlpine, William; Wang, Kuan-Wen; Lu, Tianshi; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Murray, Anne R.; Beutler, Bruce (February 14, 2017). "Creatine maintains intestinal homeostasis and protects against colitis". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1273 – E1281. Bibcode:2017PNAS..114E1273T. doi:10.1073/pnas.1621400114. ISSN 1091-6490. PMC 5321020. PMID 28137860.
Foray, Anne-Perrine; Candon, Sophie; Hildebrand, Sara; Marquet, Cindy; Valette, Fabrice; Pecquet, Coralie; Lemoine, Sebastien; Langa-Vives, Francina; Dumas, Michael; Hu, Peipei; Santamaria, Pere; You, Sylvaine; Lyon, Stephen; Scott, Lindsay; Bu, Chun Hui (November 23, 2021). "De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes". Proceedings of the National Academy of Sciences of the United States of America. 118 (47): e2112032118. Bibcode:2021PNAS..11812032F. doi:10.1073/pnas.2112032118. ISSN 1091-6490. PMC 8617500. PMID 34782469.
Zhang, Zhao; Turer, Emre; Li, Xiaohong; Zhan, Xiaoming; Choi, Mihwa; Tang, Miao; Press, Amanda; Smith, Steven R.; Divoux, Adeline; Moresco, Eva Marie Y.; Beutler, Bruce (October 18, 2016). "Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice". Proceedings of the National Academy of Sciences of the United States of America. 113 (42): E6418 – E6426. Bibcode:2016PNAS..113E6418Z. doi:10.1073/pnas.1614467113. ISSN 1091-6490. PMC 5081616. PMID 27708159.
Choi, Jin Huk; Han, Jonghee; Theodoropoulos, Panayotis C.; Zhong, Xue; Wang, Jianhui; Medler, Dawson; Ludwig, Sara; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Gallagher, Thomas; Yu, Gang; Beutler, Bruce (March 3, 2020). "Essential requirement for nicastrin in marginal zone and B-1 B cell development". Proceedings of the National Academy of Sciences of the United States of America. 117 (9): 4894–4901. Bibcode:2020PNAS..117.4894C. doi:10.1073/pnas.1916645117. ISSN 1091-6490. PMC 7060662. PMID 32071239.
Zhong, Xue; Choi, Jin Huk; Hildebrand, Sara; Ludwig, Sara; Wang, Jianhui; Nair-Gill, Evan; Liao, Tzu-Chieh; Moresco, James J.; Liu, Aijie; Quan, Jiexia; Sun, Qihua; Zhang, Duanwu; Zhan, Xiaoming; Choi, Mihwa; Li, Xiaohong (May 3, 2022). "RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice". Proceedings of the National Academy of Sciences of the United States of America. 119 (18): e2200128119. Bibcode:2022PNAS..11900128Z. doi:10.1073/pnas.2200128119. ISSN 1091-6490. PMC 9170173. PMID 35482923.
Zhong, Xue; Su, Lijing; Yang, Yi; Nair-Gill, Evan; Tang, Miao; Anderton, Priscilla; Li, Xiaohong; Wang, Jianhui; Zhan, Xiaoming; Tomchick, Diana R.; Brautigam, Chad A.; Moresco, Eva Marie Y.; Choi, Jin Huk; Beutler, Bruce (April 14, 2020). "Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function". Proceedings of the National Academy of Sciences of the United States of America. 117 (15): 8563–8572. Bibcode:2020PNAS..117.8563Z. doi:10.1073/pnas.2000703117. ISSN 1091-6490. PMC 7165429. PMID 32220963.
Choi, Jin Huk; Wang, Kuan-Wen; Zhang, Duanwu; Zhan, Xiaowei; Wang, Tao; Bu, Chun-Hui; Behrendt, Cassie L.; Zeng, Ming; Wang, Ying; Misawa, Takuma; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Scott, Lindsay; Hildebrand, Sara (February 14, 2017). "IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1196 – E1204. Bibcode:2017PNAS..114E1196C. doi:10.1073/pnas.1621258114. ISSN 1091-6490. PMC 5321007. PMID 28137874.
Du, X.; She, E.; Gelbart, T.; Truksa, J.; Lee, P.; Xia, Y.; Khovananth, K.; Mudd, S.; Mann, N.; Moresco, E. M. Y.; Beutler, E.; Beutler, B. (2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. PMC 2430097. PMID 18451267.
Du, X.; Schwander, M.; Moresco, E. M. Y.; Viviani, P.; Haller, C.; Hildebrand, M. S.; Pak, K.; Tarantino, L.; Roberts, A.; Richardson, H.; Koob, G.; Najmabadi, H.; Ryan, A. F.; Smith, R. J. H.; Muller, U.; Beutler, B. (2008). "A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy of Sciences. 105 (38): 14609–14614. Bibcode:2008PNAS..10514609D. doi:10.1073/pnas.0807219105. PMC 2567147. PMID 18794526.
Blasius, Amanda L.; Brandl, Katharina; Crozat, Karine; Xia, Yu; Khovananth, Kevin; Krebs, Philippe; Smart, Nora G.; Zampolli, Antonella; Ruggeri, Zaverio M.; Beutler, Bruce A. (February 24, 2009). "Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2706–2711. Bibcode:2009PNAS..106.2706B. doi:10.1073/pnas.0813208106. ISSN 1091-6490. PMC 2650330. PMID 19202056.
Chen, Zhe; Holland, William; Shelton, John M.; Ali, Aktar; Zhan, Xiaoming; Won, Sungyong; Tomisato, Wataru; Liu, Chen; Li, Xiaohong; Moresco, Eva Marie Y.; Beutler, Bruce (May 20, 2014). "Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 111 (20): 7367–7372. Bibcode:2014PNAS..111.7367C. doi:10.1073/pnas.1406511111. ISSN 1091-6490. PMC 4034201. PMID 24799716.
Zhang, Zhao; Gallagher, Thomas; Scherer, Philipp E.; Beutler, Bruce (May 26, 2020). "Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome". Proceedings of the National Academy of Sciences of the United States of America. 117 (21): 11829–11835. Bibcode:2020PNAS..11711829Z. doi:10.1073/pnas.2000118117. ISSN 1091-6490. PMC 7260979. PMID 32381739.
Zhang, Zhao; Xun, Yu; Rong, Shunxing; Yan, Lijuan; SoRelle, Jeffrey A.; Li, Xiaohong; Tang, Miao; Keller, Katie; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (July 16, 2022). "Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity". Nature Communications. 13 (1): 4136. Bibcode:2022NatCo..13.4136Z. doi:10.1038/s41467-022-31812-4. ISSN 2041-1723. PMC 9288484. PMID 35842425.
Smyth, Ian; Du, Xin; Taylor, Martin S.; Justice, Monica J.; Beutler, Bruce; Jackson, Ian J. (September 14, 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13560–13565. Bibcode:2004PNAS..10113560S. doi:10.1073/pnas.0402760101. ISSN 0027-8424. PMC 518794. PMID 15345741.
Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Lyon, Stephen; Pratt, David; Hildebrand, Sara; Choi, Jin Huk; Zhang, Zhao; Zeng, Ming; Wang, Kuan-wen; Turer, Emre; Chen, Zhe; Zhang, Duanwu; Yue, Tao; Wang, Ying (February 3, 2015). "Real-time resolution of point mutations that cause phenovariance in mice". Proceedings of the National Academy of Sciences of the United States of America. 112 (5): E440–449. Bibcode:2015PNAS..112E.440W. doi:10.1073/pnas.1423216112. ISSN 1091-6490. PMC 4321302. PMID 25605905.
Wang, Tao; Bu, Chun Hui; Hildebrand, Sara; Jia, Gaoxiang; Siggs, Owen M.; Lyon, Stephen; Pratt, David; Scott, Lindsay; Russell, Jamie; Ludwig, Sara; Murray, Anne R.; Moresco, Eva Marie Y.; Beutler, Bruce (January 30, 2018). "Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database". Nature Communications. 9 (1): 441. Bibcode:2018NatCo...9..441W. doi:10.1038/s41467-017-02806-4. ISSN 2041-1723. PMC 5789985. PMID 29382827.
Xu, Darui; Lyon, Stephen; Bu, Chun Hui; Hildebrand, Sara; Choi, Jin Huk; Zhong, Xue; Liu, Aijie; Turer, Emre E.; Zhang, Zhao; Russell, Jamie; Ludwig, Sara; Mahrt, Elena; Nair-Gill, Evan; Shi, Hexin; Wang, Ying (July 13, 2021). "Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning". Proceedings of the National Academy of Sciences of the United States of America. 118 (28): e2106786118. Bibcode:2021PNAS..11806786X. doi:10.1073/pnas.2106786118. ISSN 1091-6490. PMC 8285956. PMID 34260399.
Chen, Bo; Aredo, Bogale; Ding, Yi; Zhong, Xin; Zhu, Yuanfei; Zhao, Cynthia X.; Kumar, Ashwani; Xing, Chao; Gautron, Laurent; Lyon, Stephen; Russell, Jamie; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Ludwig, Sara (June 9, 2020). "Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 12931–12942. Bibcode:2020PNAS..11712931C. doi:10.1073/pnas.1921224117. ISSN 1091-6490. PMC 7293615. PMID 32457148.
Wang, Yibing; Cao, Liqin; Lee, Chia-Ying; Matsuo, Tomohiko; Wu, Kejia; Asher, Greg; Tang, Lijun; Saitoh, Tsuyoshi; Russell, Jamie; Klewe-Nebenius, Daniela; Wang, Li; Soya, Shingo; Hasegawa, Emi; Chérasse, Yoan; Zhou, Jiamin (May 23, 2018). "Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors". Nature Communications. 9 (1): 2041. Bibcode:2018NatCo...9.2041W. doi:10.1038/s41467-018-04324-3. ISSN 2041-1723. PMC 5966455. PMID 29795268.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Mifune, Yuto; Shi, Hexin; Wang, Kuan-Wen; Zhan, Xiaoming; Liu, Aijie; Wang, Jianhui; Li, Xiaohong; Tang, Miao; Ludwig, Sara; Hildebrand, Sara; Zhou, Kejin (September 11, 2018). "Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice". Proceedings of the National Academy of Sciences of the United States of America. 115 (37): E8698 – E8706. Bibcode:2018PNAS..115E8698W. doi:10.1073/pnas.1809232115. ISSN 1091-6490. PMC 6140543. PMID 30150374.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Whitby, Landon R.; Surakattula, Murali M. R. P.; Huang, Hua; Shi, Hexin; Choi, Jin Huk; Wang, Kuan-wen; Moresco, Eva Marie Y.; Berger, Michael; Zhan, Xiaoming; Zhang, Hong; Boger, Dale L. (February 16, 2016). "TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS". Proceedings of the National Academy of Sciences of the United States of America. 113 (7): E884–893. Bibcode:2016PNAS..113E.884W. doi:10.1073/pnas.1525639113. ISSN 1091-6490. PMC 4763747. PMID 26831104.
Su, Lijing; Athamna, Muhammad; Wang, Ying; Wang, Junmei; Freudenberg, Marina; Yue, Tao; Wang, Jianhui; Moresco, Eva Marie Y.; He, Haoming; Zor, Tsaffrir; Beutler, Bruce (July 27, 2021). "Sulfatides are endogenous ligands for the TLR4-MD-2 complex". Proceedings of the National Academy of Sciences of the United States of America. 118 (30): e2105316118. Bibcode:2021PNAS..11805316S. doi:10.1073/pnas.2105316118. ISSN 1091-6490. PMC 8325290. PMID 34290146.
Beutler, E.; Yeh, M.; Fairbanks, V. F. (January 15, 1962). "The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker". Proceedings of the National Academy of Sciences of the United States of America. 48 (1): 9–16. Bibcode:1962PNAS...48....9B. doi:10.1073/pnas.48.1.9. ISSN 0027-8424. PMC 285481. PMID 13868717.
Beutler, E.; Gelbart, T.; Han, J. H.; Koziol, J. A.; Beutler, B. (January 1989). "Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage". Proceedings of the National Academy of Sciences of the United States of America. 86 (1): 192–196. Bibcode:1989PNAS...86..192B. doi:10.1073/pnas.86.1.192. ISSN 0027-8424. PMC 286430. PMID 2463621.
Du, Xin; She, Ellen; Gelbart, Terri; Truksa, Jaroslav; Lee, Pauline; Xia, Yu; Khovananth, Kevin; Mudd, Suzanne; Mann, Navjiwan; Moresco, Eva Marie Y.; Beutler, Ernest; Beutler, Bruce (May 23, 2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. ISSN 1095-9203. PMC 2430097. PMID 18451267.

hematology.org

Wailoo, Keith. "Ernest Beutler QA - Hematology.org". Retrieved March 9, 2023.

nih.gov

pubmed.ncbi.nlm.nih.gov

Poltorak, A.; He, X.; Smirnova, I.; Liu, M. Y.; Van Huffel, C.; Du, X.; Birdwell, D.; Alejos, E.; Silva, M.; Galanos, C.; Freudenberg, M.; Ricciardi-Castagnoli, P.; Layton, B.; Beutler, B. (December 11, 1998). "Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene". Science. 282 (5396): 2085–2088. doi:10.1126/science.282.5396.2085. ISSN 0036-8075. PMID 9851930.
Hemmi, Hiroaki; Kaisho, Tsuneyasu; Takeuchi, Osamu; Sato, Shintaro; Sanjo, Hideki; Hoshino, Katsuaki; Horiuchi, Takao; Tomizawa, Hideyuki; Takeda, Kiyoshi; Akira, Shizuo (January 22, 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nature Immunology. 3 (2): 196–200. doi:10.1038/ni758. ISSN 1529-2908. PMID 11812998. S2CID 1694900.
Hemmi, H.; Takeuchi, O.; Kawai, T.; Kaisho, T.; Sato, S.; Sanjo, H.; Matsumoto, M.; Hoshino, K.; Wagner, H.; Takeda, K.; Akira, S. (December 7, 2000). "A Toll-like receptor recognizes bacterial DNA". Nature. 408 (6813): 740–745. Bibcode:2000Natur.408..740H. doi:10.1038/35047123. ISSN 0028-0836. PMID 11130078. S2CID 4405163.
Takeuchi, O.; Hoshino, K.; Kawai, T.; Sanjo, H.; Takada, H.; Ogawa, T.; Takeda, K.; Akira, S. (October 1, 1999). "Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components". Immunity. 11 (4): 443–451. doi:10.1016/s1074-7613(00)80119-3. ISSN 1074-7613. PMID 10549626.
Takeuchi, O.; Kawai, T.; Mühlradt, P. F.; Morr, M.; Radolf, J. D.; Zychlinsky, A.; Takeda, K.; Akira, S. (July 1, 2001). "Discrimination of bacterial lipoproteins by Toll-like receptor 6". International Immunology. 13 (7): 933–940. doi:10.1093/intimm/13.7.933. ISSN 0953-8178. PMID 11431423.
Takeuchi, Osamu; Sato, Shintaro; Horiuchi, Takao; Hoshino, Katsuaki; Takeda, Kiyoshi; Dong, Zhongyun; Modlin, Robert L.; Akira, Shizuo (July 1, 2002). "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". Journal of Immunology. 169 (1): 10–14. doi:10.4049/jimmunol.169.1.10. ISSN 0022-1767. PMID 12077222. S2CID 22686400.
Ravindran, S. (2013). "Profile of Bruce A. Beutler". Proceedings of the National Academy of Sciences. 110 (32): 12857–8. Bibcode:2013PNAS..11012857R. doi:10.1073/pnas.1311624110. PMC 3740904. PMID 23858464.
Beutler, E.; West, C.; Beutler, B. (October 1974). "Electrophoretic polymorphism of glutathione peroxidase". Annals of Human Genetics. 38 (2): 163–169. doi:10.1111/j.1469-1809.1974.tb01947.x. ISSN 0003-4800. PMID 4467780. S2CID 32294741.
Beutler, E.; Beutler, B.; Matsumoto, J. (July 15, 1975). "Glutathione peroxidase activity of inorganic selenium and seleno-DL-cysteine". Experientia. 31 (7): 769–770. doi:10.1007/BF01938453. ISSN 0014-4754. PMID 1140308. S2CID 26234261.
Ohno, S. (January 1977). "The original function of MHC antigens as the general plasma membrane anchorage site of organogenesis-directing proteins". Immunological Reviews. 33: 59–69. doi:10.1111/j.1600-065X.1977.tb00362.x. ISSN 0105-2896. PMID 66186. S2CID 45992817.
Beutler, B.; Nagai, Y.; Ohno, S.; Klein, G.; Shapiro, I. M. (March 1978). "The HLA-dependent expression of testis- organizing H-Y antigen by human male cells". Cell. 13 (3): 509–513. doi:10.1016/0092-8674(78)90324-0. ISSN 0092-8674. PMID 77737. S2CID 33827976.
Beutler, B.; Greenwald, D.; Hulmes, J. D.; Chang, M.; Pan, Y. C.; Mathison, J.; Ulevitch, R.; Cerami, A. (August 1, 1985). "Identity of tumour necrosis factor and the macrophage-secreted factor cachectin". Nature. 316 (6028): 552–554. Bibcode:1985Natur.316..552B. doi:10.1038/316552a0. ISSN 0028-0836. PMID 2993897. S2CID 4339006.
Beutler, B.; Mahoney, J.; Le Trang, N.; Pekala, P.; Cerami, A. (May 1, 1985). "Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells". The Journal of Experimental Medicine. 161 (5): 984–995. doi:10.1084/jem.161.5.984. ISSN 0022-1007. PMC 2187615. PMID 3872925.
Aggarwal, B. B.; Kohr, W. J.; Hass, P. E.; Moffat, B.; Spencer, S. A.; Henzel, W. J.; Bringman, T. S.; Nedwin, G. E.; Goeddel, D. V.; Harkins, R. N. (February 25, 1985). "Human tumor necrosis factor. Production, purification, and characterization". The Journal of Biological Chemistry. 260 (4): 2345–2354. doi:10.1016/S0021-9258(18)89560-6. ISSN 0021-9258. PMID 3871770.
Beutler, B.; Milsark, I. W.; Cerami, A. C. (August 30, 1985). "Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin". Science. 229 (4716): 869–871. Bibcode:1985Sci...229..869B. doi:10.1126/science.3895437. ISSN 0036-8075. PMID 3895437.
Dayer, J. M.; Beutler, B.; Cerami, A. (December 1, 1985). "Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts". The Journal of Experimental Medicine. 162 (6): 2163–2168. doi:10.1084/jem.162.6.2163. ISSN 0022-1007. PMC 2187983. PMID 2999289.
Feldmann, M.; Brennan, F. M.; Maini, R. N. (1996). "Role of cytokines in rheumatoid arthritis". Annual Review of Immunology. 14: 397–440. doi:10.1146/annurev.immunol.14.1.397. ISSN 0732-0582. PMID 8717520.
Engelmann, H.; Novick, D.; Wallach, D. (January 25, 1990). "Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors". The Journal of Biological Chemistry. 265 (3): 1531–1536. doi:10.1016/S0021-9258(19)40049-5. ISSN 0021-9258. PMID 2153136.
Loetscher, H.; Pan, Y. C.; Lahm, H. W.; Gentz, R.; Brockhaus, M.; Tabuchi, H.; Lesslauer, W. (April 20, 1990). "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor". Cell. 61 (2): 351–359. doi:10.1016/0092-8674(90)90815-v. ISSN 0092-8674. PMID 2158862. S2CID 42245440.
Nophar, Y.; Kemper, O.; Brakebusch, C.; Englemann, H.; Zwang, R.; Aderka, D.; Holtmann, H.; Wallach, D. (October 1, 1990). "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor". The EMBO Journal. 9 (10): 3269–3278. doi:10.1002/j.1460-2075.1990.tb07526.x. ISSN 0261-4189. PMC 552060. PMID 1698610.
Schall, T. J.; Lewis, M.; Koller, K. J.; Lee, A.; Rice, G. C.; Wong, G. H.; Gatanaga, T.; Granger, G. A.; Lentz, R.; Raab, H. (April 20, 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell. 61 (2): 361–370. doi:10.1016/0092-8674(90)90816-w. ISSN 0092-8674. PMID 2158863. S2CID 36187863.
Smith, C. A.; Davis, T.; Anderson, D.; Solam, L.; Beckmann, M. P.; Jerzy, R.; Dower, S. K.; Cosman, D.; Goodwin, R. G. (May 25, 1990). "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins". Science. 248 (4958): 1019–1023. Bibcode:1990Sci...248.1019S. doi:10.1126/science.2160731. ISSN 0036-8075. PMID 2160731.
Poltorak, A.; Peppel, K.; Beutler, B. (February 28, 1994). "Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations". Journal of Immunological Methods. 169 (1): 93–99. doi:10.1016/0022-1759(94)90128-7. ISSN 0022-1759. PMID 8133076.
Peppel, K.; Crawford, D.; Beutler, B. (December 1, 1991). "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity". The Journal of Experimental Medicine. 174 (6): 1483–1489. doi:10.1084/jem.174.6.1483. ISSN 0022-1007. PMC 2119031. PMID 1660525.
Beutler, B.; Poltorak, A. (July 2001). "Sepsis and evolution of the innate immune response". Critical Care Medicine. 29 (7 Suppl): S2–6, discussion S6–7. doi:10.1097/00003246-200107001-00002. ISSN 0090-3493. PMID 11445725.
Johnson, A. G.; Gaines, S.; Landy, M. (February 1, 1956). "Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide". The Journal of Experimental Medicine. 103 (2): 225–246. doi:10.1084/jem.103.2.225. ISSN 0022-1007. PMC 2136584. PMID 13286429.
Coutinho, A.; Meo, T. (December 1978). "Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice". Immunogenetics. 7 (1): 17–24. doi:10.1007/BF01843983. ISSN 0093-7711. PMID 21302052. S2CID 29425605.
Watson, J.; Riblet, R. (November 1, 1974). "Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic respones [sic] to lipopolysaccharides". The Journal of Experimental Medicine. 140 (5): 1147–1161. doi:10.1084/jem.140.5.1147. ISSN 0022-1007. PMC 2139714. PMID 4138849.
Sultzer, B. M. (September 21, 1968). "Genetic control of leucocyte responses to endotoxin". Nature. 219 (5160): 1253–1254. Bibcode:1968Natur.219.1253S. doi:10.1038/2191253a0. ISSN 0028-0836. PMID 4877918. S2CID 41633552.
Beutler, Bruce (January 2002). "Toll-like receptors: how they work and what they do". Current Opinion in Hematology. 9 (1): 2–10. doi:10.1097/00062752-200201000-00002. ISSN 1065-6251. PMID 11753071. S2CID 36843541.
Du, X.; Poltorak, A.; Silva, M.; Beutler, B. (1999). "Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor". Blood Cells, Molecules & Diseases. 25 (5–6): 328–338. doi:10.1006/bcmd.1999.0262. ISSN 1079-9796. PMID 10660480.
Poltorak, A.; Ricciardi-Castagnoli, P.; Citterio, S.; Beutler, B. (February 29, 2000). "Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2163–2167. Bibcode:2000PNAS...97.2163P. doi:10.1073/pnas.040565397. ISSN 0027-8424. PMC 15771. PMID 10681462.
Shimazu, R.; Akashi, S.; Ogata, H.; Nagai, Y.; Fukudome, K.; Miyake, K.; Kimoto, M. (June 7, 1999). "MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4". The Journal of Experimental Medicine. 189 (11): 1777–1782. doi:10.1084/jem.189.11.1777. ISSN 0022-1007. PMC 2193086. PMID 10359581.
Park, Beom Seok; Song, Dong Hyun; Kim, Ho Min; Choi, Byong-Seok; Lee, Hayyoung; Lee, Jie-Oh (April 30, 2009). "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex". Nature. 458 (7242): 1191–1195. Bibcode:2009Natur.458.1191P. doi:10.1038/nature07830. ISSN 1476-4687. PMID 19252480. S2CID 4396446.
Lemaitre, B.; Nicolas, E.; Michaut, L.; Reichhart, J. M.; Hoffmann, J. A. (September 20, 1996). "The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults". Cell. 86 (6): 973–983. doi:10.1016/s0092-8674(00)80172-5. ISSN 0092-8674. PMID 8808632. S2CID 10736743.
Medzhitov, R.; Preston-Hurlburt, P.; Janeway, C. A. (July 24, 1997). "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity". Nature. 388 (6640): 394–397. doi:10.1038/41131. ISSN 0028-0836. PMID 9237759. S2CID 4311321.
Kirschning, C. J.; Wesche, H.; Merrill Ayres, T.; Rothe, M. (December 7, 1998). "Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide". The Journal of Experimental Medicine. 188 (11): 2091–2097. doi:10.1084/jem.188.11.2091. ISSN 0022-1007. PMC 2212382. PMID 9841923.
Yang, R. B.; Mark, M. R.; Gray, A.; Huang, A.; Xie, M. H.; Zhang, M.; Goddard, A.; Wood, W. I.; Gurney, A. L.; Godowski, P. J. (September 17, 1998). "Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling". Nature. 395 (6699): 284–288. Bibcode:1998Natur.395..284Y. doi:10.1038/26239. ISSN 0028-0836. PMID 9751057. S2CID 4422827.
Beutler, B.; Poltorak, A. (June 2000). "Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response". European Cytokine Network. 11 (2): 143–152. ISSN 1148-5493. PMID 10903793.
Christensen, Sean R.; Shupe, Jonathan; Nickerson, Kevin; Kashgarian, Michael; Flavell, Richard A.; Shlomchik, Mark J. (September 2006). "Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus". Immunity. 25 (3): 417–428. doi:10.1016/j.immuni.2006.07.013. ISSN 1074-7613. PMID 16973389.
Brown, Grant J.; Cañete, Pablo F.; Wang, Hao; Medhavy, Arti; Bones, Josiah; Roco, Jonathan A.; He, Yuke; Qin, Yuting; Cappello, Jean; Ellyard, Julia I.; Bassett, Katharine; Shen, Qian; Burgio, Gaetan; Zhang, Yaoyuan; Turnbull, Cynthia (May 2022). "TLR7 gain-of-function genetic variation causes human lupus". Nature. 605 (7909): 349–356. Bibcode:2022Natur.605..349B. doi:10.1038/s41586-022-04642-z. ISSN 1476-4687. PMC 9095492. PMID 35477763.
Leibler, Claire; John, Shinu; Elsner, Rebecca A.; Thomas, Kayla B.; Smita, Shuchi; Joachim, Stephen; Levack, Russell C.; Callahan, Derrick J.; Gordon, Rachael A.; Bastacky, Sheldon; Fukui, Ryutaro; Miyake, Kensuke; Gingras, Sebastien; Nickerson, Kevin M.; Shlomchik, Mark J. (October 2022). "Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus". Nature Immunology. 23 (10): 1457–1469. doi:10.1038/s41590-022-01310-2. ISSN 1529-2916. PMC 9561083. PMID 36151396.
Baccala, Roberto; Gonzalez-Quintial, Rosana; Blasius, Amanda L.; Rimann, Ivo; Ozato, Keiko; Kono, Dwight H.; Beutler, Bruce; Theofilopoulos, Argyrios N. (February 19, 2013). "Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus". Proceedings of the National Academy of Sciences of the United States of America. 110 (8): 2940–2945. Bibcode:2013PNAS..110.2940B. doi:10.1073/pnas.1222798110. ISSN 1091-6490. PMC 3581947. PMID 23382217.
Kono, Dwight H.; Haraldsson, M. Katarina; Lawson, Brian R.; Pollard, K. Michael; Koh, Yi Ting; Du, Xin; Arnold, Carrie N.; Baccala, Roberto; Silverman, Gregg J.; Beutler, Bruce A.; Theofilopoulos, Argyrios N. (July 21, 2009). "Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus". Proceedings of the National Academy of Sciences of the United States of America. 106 (29): 12061–12066. Bibcode:2009PNAS..10612061K. doi:10.1073/pnas.0905441106. ISSN 1091-6490. PMC 2715524. PMID 19574451.
Lau, Christina M.; Broughton, Courtney; Tabor, Abigail S.; Akira, Shizuo; Flavell, Richard A.; Mamula, Mark J.; Christensen, Sean R.; Shlomchik, Mark J.; Viglianti, Gregory A.; Rifkin, Ian R.; Marshak-Rothstein, Ann (November 7, 2005). "RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement". The Journal of Experimental Medicine. 202 (9): 1171–1177. doi:10.1084/jem.20050630. ISSN 0022-1007. PMC 2213226. PMID 16260486.
Leadbetter, Elizabeth A.; Rifkin, Ian R.; Hohlbaum, Andreas M.; Beaudette, Britte C.; Shlomchik, Mark J.; Marshak-Rothstein, Ann (April 11, 2002). "Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors". Nature. 416 (6881): 603–607. doi:10.1038/416603a. ISSN 0028-0836. PMID 11948342. S2CID 4370544.
Viglianti, Gregory A.; Lau, Christina M.; Hanley, Timothy M.; Miko, Benjamin A.; Shlomchik, Mark J.; Marshak-Rothstein, Ann (December 2003). "Activation of autoreactive B cells by CpG dsDNA". Immunity. 19 (6): 837–847. doi:10.1016/s1074-7613(03)00323-6. ISSN 1074-7613. PMID 14670301.
Beutler, Bruce; Du, Xin; Xia, Yu (July 2007). "Precis on forward genetics in mice". Nature Immunology. 8 (7): 659–664. doi:10.1038/ni0707-659. ISSN 1529-2908. PMID 17579639. S2CID 28309476.
Hoebe, K.; Du, X.; Georgel, P.; Janssen, E.; Tabeta, K.; Kim, S. O.; Goode, J.; Lin, P.; Mann, N.; Mudd, S.; Crozat, K.; Sovath, S.; Han, J.; Beutler, B. (August 14, 2003). "Identification of Lps2 as a key transducer of MyD88-independent TIR signalling". Nature. 424 (6950): 743–748. Bibcode:2003Natur.424..743H. doi:10.1038/nature01889. ISSN 1476-4687. PMID 12872135. S2CID 15608748.
Hoebe, Kasper; Georgel, Philippe; Rutschmann, Sophie; Du, Xin; Mudd, Suzanne; Crozat, Karine; Sovath, Sosathya; Shamel, Louis; Hartung, Thomas; Zähringer, Ulrich; Beutler, Bruce (February 3, 2005). "CD36 is a sensor of diacylglycerides". Nature. 433 (7025): 523–527. Bibcode:2005Natur.433..523H. doi:10.1038/nature03253. ISSN 1476-4687. PMID 15690042. S2CID 4406318.
Tabeta, Koichi; Hoebe, Kasper; Janssen, Edith M.; Du, Xin; Georgel, Philippe; Crozat, Karine; Mudd, Suzanne; Mann, Navjiwan; Sovath, Sosathya; Goode, Jason; Shamel, Louis; Herskovits, Anat A.; Portnoy, Daniel A.; Cooke, Michael; Tarantino, Lisa M. (January 15, 2006). "The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9". Nature Immunology. 7 (2): 156–164. doi:10.1038/ni1297. ISSN 1529-2908. PMID 16415873. S2CID 33401155.
Croker, Ben A.; Lawson, Brian R.; Rutschmann, Sophie; Berger, Michael; Eidenschenk, Celine; Blasius, Amanda L.; Moresco, Eva Marie Y.; Sovath, Sosathya; Cengia, Louise; Shultz, Leonard D.; Theofilopoulos, Argyrios N.; Pettersson, Sven; Beutler, Bruce Alan (September 30, 2008). "Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger". Proceedings of the National Academy of Sciences of the United States of America. 105 (39): 15028–15033. Bibcode:2008PNAS..10515028C. doi:10.1073/pnas.0806619105. ISSN 1091-6490. PMC 2567487. PMID 18806225.
Shi, Hexin; Wang, Ying; Li, Xiaohong; Zhan, Xiaoming; Tang, Miao; Fina, Maggy; Su, Lijing; Pratt, David; Bu, Chun Hui; Hildebrand, Sara; Lyon, Stephen; Scott, Lindsay; Quan, Jiexia; Sun, Qihua; Russell, Jamie (December 7, 2015). "NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component". Nature Immunology. 17 (3): 250–258. doi:10.1038/ni.3333. ISSN 1529-2916. PMC 4862588. PMID 26642356.
Sun, Lei; Jiang, Zhengfan; Acosta-Rodriguez, Victoria A.; Berger, Michael; Du, Xin; Choi, Jin Huk; Wang, Jianhui; Wang, Kuan-Wen; Kilaru, Gokhul K.; Mohawk, Jennifer A.; Quan, Jiexia; Scott, Lindsay; Hildebrand, Sara; Li, Xiaohong; Tang, Miao (November 6, 2017). "HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections". The Journal of Experimental Medicine. 214 (11): 3263–3277. doi:10.1084/jem.20161630. ISSN 1540-9538. PMC 5679162. PMID 28970238.
Shi, Hexin; Sun, Lei; Wang, Ying; Liu, Aijie; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Hildebrand, Sara; Quan, Jiexia; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (March 2, 2021). "N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization". Nature Communications. 12 (1): 1379. Bibcode:2021NatCo..12.1379S. doi:10.1038/s41467-021-21711-5. ISSN 2041-1723. PMC 7925594. PMID 33654074.
Kim, You-Me; Brinkmann, Melanie M.; Paquet, Marie-Eve; Ploegh, Hidde L. (March 13, 2008). "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes". Nature. 452 (7184): 234–238. Bibcode:2008Natur.452..234K. doi:10.1038/nature06726. ISSN 1476-4687. PMID 18305481. S2CID 4397023.
Casrouge, Armanda; Zhang, Shen-Ying; Eidenschenk, Céline; Jouanguy, Emmanuelle; Puel, Anne; Yang, Kun; Alcais, Alexandre; Picard, Capucine; Mahfoufi, Nora; Nicolas, Nathalie; Lorenzo, Lazaro; Plancoulaine, Sabine; Sénéchal, Brigitte; Geissmann, Frédéric; Tabeta, Koichi (October 13, 2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797): 308–312. Bibcode:2006Sci...314..308C. doi:10.1126/science.1128346. ISSN 1095-9203. PMID 16973841. S2CID 12501759.
Blasius, Amanda L.; Arnold, Carrie N.; Georgel, Philippe; Rutschmann, Sophie; Xia, Yu; Lin, Pei; Ross, Charles; Li, Xiaohong; Smart, Nora G.; Beutler, Bruce (November 16, 2010). "Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19973–19978. Bibcode:2010PNAS..10719973B. doi:10.1073/pnas.1014051107. ISSN 1091-6490. PMC 2993408. PMID 21045126.
Beutler, Bruce; Crozat, Karine; Koziol, James A.; Georgel, Philippe (February 2005). "Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model". Current Opinion in Immunology. 17 (1): 36–43. doi:10.1016/j.coi.2004.11.004. ISSN 0952-7915. PMID 15653308.
Beutler, Bruce; Eidenschenk, Celine; Crozat, Karine; Imler, Jean-Luc; Takeuchi, Osamu; Hoffmann, Jules A.; Akira, Shizuo (October 2007). "Genetic analysis of resistance to viral infection". Nature Reviews. Immunology. 7 (10): 753–766. doi:10.1038/nri2174. ISSN 1474-1741. PMID 17893693. S2CID 37705652.
Croker, B.; Crozat, K.; Berger, M.; Xia, Y.; Sovath, S.; Schaffer, L.; Eleftherianos, I.; Imler, J. L.; Beutler, B. (2007). "ATP-sensitive potassium channels mediate survival during infection in mammals and insects". Nature Genetics. 39 (12): 1453–1460. doi:10.1038/ng.2007.25. PMID 18026101. S2CID 41183715.
Brandl, Katharina; Rutschmann, Sophie; Li, Xiaohong; Du, Xin; Xiao, Nengming; Schnabl, Bernd; Brenner, David A.; Beutler, Bruce (March 3, 2009). "Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3300–3305. Bibcode:2009PNAS..106.3300B. doi:10.1073/pnas.0813036106. ISSN 1091-6490. PMC 2651297. PMID 19202076.
Brandl, Katharina; Sun, Lei; Neppl, Christina; Siggs, Owen M.; Le Gall, Sylvain M.; Tomisato, Wataru; Li, Xiaohong; Du, Xin; Maennel, Daniela N.; Blobel, Carl P.; Beutler, Bruce (November 16, 2010). "MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19967–19972. Bibcode:2010PNAS..10719967B. doi:10.1073/pnas.1014669107. ISSN 1091-6490. PMC 2993336. PMID 21041656.
Brandl, Katharina; Tomisato, Wataru; Li, Xiaohong; Neppl, Christina; Pirie, Elaine; Falk, Werner; Xia, Yu; Moresco, Eva Marie Y.; Baccala, Roberto; Theofilopoulos, Argyrios N.; Schnabl, Bernd; Beutler, Bruce (July 31, 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12650–12655. Bibcode:2012PNAS..10912650B. doi:10.1073/pnas.1210366109. ISSN 1091-6490. PMC 3412000. PMID 22802641.
McAlpine, William; Sun, Lei; Wang, Kuan-Wen; Liu, Aijie; Jain, Ruchi; San Miguel, Miguel; Wang, Jianhui; Zhang, Zhao; Hayse, Braden; McAlpine, Sarah Grace; Choi, Jin Huk; Zhong, Xue; Ludwig, Sara; Russell, Jamie; Zhan, Xiaoming (December 4, 2018). "Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function". Proceedings of the National Academy of Sciences of the United States of America. 115 (49): E11523 – E11531. Bibcode:2018PNAS..11511523M. doi:10.1073/pnas.1814753115. ISSN 1091-6490. PMC 6298088. PMID 30442666.
McAlpine, William; Wang, Kuan-Wen; Choi, Jin Huk; San Miguel, Miguel; McAlpine, Sarah Grace; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao; Bu, Chun Hui; Murray, Anne R.; Moresco, Eva Marie Y. (September 27, 2018). "The class I myosin MYO1D binds to lipid and protects against colitis". Disease Models & Mechanisms. 11 (9): dmm035923. doi:10.1242/dmm.035923. ISSN 1754-8411. PMC 6176994. PMID 30279225.
Wang, Kuan-Wen; Zhan, Xiaoming; McAlpine, William; Zhang, Zhao; Choi, Jin Huk; Shi, Hexin; Misawa, Takuma; Yue, Tao; Zhang, Duanwu; Wang, Ying; Ludwig, Sara; Russell, Jamie; Tang, Miao; Li, Xiaohong; Murray, Anne R. (June 4, 2019). "Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice". Proceedings of the National Academy of Sciences of the United States of America. 116 (23): 11380–11389. Bibcode:2019PNAS..11611380W. doi:10.1073/pnas.1901407116. ISSN 1091-6490. PMC 6561264. PMID 31097594.
Turer, Emre; McAlpine, William; Wang, Kuan-Wen; Lu, Tianshi; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Murray, Anne R.; Beutler, Bruce (February 14, 2017). "Creatine maintains intestinal homeostasis and protects against colitis". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1273 – E1281. Bibcode:2017PNAS..114E1273T. doi:10.1073/pnas.1621400114. ISSN 1091-6490. PMC 5321020. PMID 28137860.
SoRelle, Jeffrey A.; Chen, Zhe; Wang, Jianhui; Yue, Tao; Choi, Jin Huk; Wang, Kuan-Wen; Zhong, Xue; Hildebrand, Sara; Russell, Jamie; Scott, Lindsay; Xu, Darui; Zhan, Xiaowei; Bu, Chun Hui; Wang, Tao; Choi, Mihwa (April 2021). "Dominant atopy risk mutations identified by mouse forward genetic analysis". Allergy. 76 (4): 1095–1108. doi:10.1111/all.14564. ISSN 1398-9995. PMC 7889751. PMID 32810290.
Chatenoud, Lucienne; Marquet, Cindy; Valette, Fabrice; Scott, Lindsay; Quan, Jiexia; Bu, Chun Hui; Hildebrand, Sara; Moresco, Eva Marie Y.; Bach, Jean-François; Beutler, Bruce (June 1, 2022). "Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice". Disease Models & Mechanisms. 15 (6): dmm049484. doi:10.1242/dmm.049484. ISSN 1754-8411. PMC 9178510. PMID 35502705.
Foray, Anne-Perrine; Candon, Sophie; Hildebrand, Sara; Marquet, Cindy; Valette, Fabrice; Pecquet, Coralie; Lemoine, Sebastien; Langa-Vives, Francina; Dumas, Michael; Hu, Peipei; Santamaria, Pere; You, Sylvaine; Lyon, Stephen; Scott, Lindsay; Bu, Chun Hui (November 23, 2021). "De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes". Proceedings of the National Academy of Sciences of the United States of America. 118 (47): e2112032118. Bibcode:2021PNAS..11812032F. doi:10.1073/pnas.2112032118. ISSN 1091-6490. PMC 8617500. PMID 34782469.
Zhang, Zhao; Turer, Emre; Li, Xiaohong; Zhan, Xiaoming; Choi, Mihwa; Tang, Miao; Press, Amanda; Smith, Steven R.; Divoux, Adeline; Moresco, Eva Marie Y.; Beutler, Bruce (October 18, 2016). "Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice". Proceedings of the National Academy of Sciences of the United States of America. 113 (42): E6418 – E6426. Bibcode:2016PNAS..113E6418Z. doi:10.1073/pnas.1614467113. ISSN 1091-6490. PMC 5081616. PMID 27708159.
Turer, Emre E.; San Miguel, Miguel; Wang, Kuan-Wen; McAlpine, William; Ou, Feiya; Li, Xiaohong; Tang, Miao; Zang, Zhao; Wang, Jianhui; Hayse, Braden; Evers, Bret; Zhan, Xiaoming; Russell, Jamie; Beutler, Bruce (December 18, 2018). "A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis". Disease Models & Mechanisms. 11 (12): dmm035451. doi:10.1242/dmm.035451. ISSN 1754-8411. PMC 6307907. PMID 30563851.
Zhang, Zhao; Jiang, Yiao; Su, Lijing; Ludwig, Sara; Zhang, Xuechun; Tang, Miao; Li, Xiaohong; Anderton, Priscilla; Zhan, Xiaoming; Choi, Mihwa; Russell, Jamie; Bu, Chun-Hui; Lyon, Stephen; Xu, Darui; Hildebrand, Sara (November 1, 2022). "Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis". Cell Metabolism. 34 (11): 1860–1874.e4. doi:10.1016/j.cmet.2022.09.018. ISSN 1932-7420. PMC 9633419. PMID 36228616.
Berger, Michael; Krebs, Philippe; Crozat, Karine; Li, Xiaohong; Croker, Ben A.; Siggs, Owen M.; Popkin, Daniel; Du, Xin; Lawson, Brian R.; Theofilopoulos, Argyrios N.; Xia, Yu; Khovananth, Kevin; Moresco, Eva Marie; Satoh, Takashi; Takeuchi, Osamu (April 2010). "An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence". Nature Immunology. 11 (4): 335–343. doi:10.1038/ni.1847. ISSN 1529-2916. PMC 2861894. PMID 20190759.
Siggs, Owen M.; Arnold, Carrie N.; Huber, Christoph; Pirie, Elaine; Xia, Yu; Lin, Pei; Nemazee, David; Beutler, Bruce (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–440. doi:10.1038/ni.2012. ISSN 1529-2916. PMC 3079768. PMID 21423172.
Siggs, Owen M.; Li, Xiaohong; Xia, Yu; Beutler, Bruce (January 16, 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. ISSN 1540-9538. PMC 3260866. PMID 22201126.
Choi, Jin Huk; Han, Jonghee; Theodoropoulos, Panayotis C.; Zhong, Xue; Wang, Jianhui; Medler, Dawson; Ludwig, Sara; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Gallagher, Thomas; Yu, Gang; Beutler, Bruce (March 3, 2020). "Essential requirement for nicastrin in marginal zone and B-1 B cell development". Proceedings of the National Academy of Sciences of the United States of America. 117 (9): 4894–4901. Bibcode:2020PNAS..117.4894C. doi:10.1073/pnas.1916645117. ISSN 1091-6490. PMC 7060662. PMID 32071239.
Choi, Jin Huk; Zhong, Xue; McAlpine, William; Liao, Tzu-Chieh; Zhang, Duanwu; Fang, Beibei; Russell, Jamie; Ludwig, Sara; Nair-Gill, Evan; Zhang, Zhao; Wang, Kuan-Wen; Misawa, Takuma; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao (May 10, 2019). "LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling". Science. 364 (6440): eaau0812. doi:10.1126/science.aau0812. ISSN 1095-9203. PMC 7206793. PMID 31073040.
Choi, Jin Huk; Zhong, Xue; Zhang, Zhao; Su, Lijing; McAlpine, William; Misawa, Takuma; Liao, Tzu-Chieh; Zhan, Xiaoming; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Moresco, Eva Marie Y.; Beutler, Bruce (April 6, 2020). "Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development". The Journal of Experimental Medicine. 217 (4): e20190006. doi:10.1084/jem.20190006. ISSN 1540-9538. PMC 7144532. PMID 31985756.
Zhang, Duanwu; Yue, Tao; Choi, Jin Huk; Nair-Gill, Evan; Zhong, Xue; Wang, Kuan-Wen; Zhan, Xiaoming; Li, Xiaohong; Choi, Mihwa; Tang, Miao; Quan, Jiexia; Hildebrand, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (October 2019). "Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40". Nature Immunology. 20 (10): 1322–1334. doi:10.1038/s41590-019-0464-4. ISSN 1529-2916. PMC 7179765. PMID 31427773.
Zhong, Xue; Choi, Jin Huk; Hildebrand, Sara; Ludwig, Sara; Wang, Jianhui; Nair-Gill, Evan; Liao, Tzu-Chieh; Moresco, James J.; Liu, Aijie; Quan, Jiexia; Sun, Qihua; Zhang, Duanwu; Zhan, Xiaoming; Choi, Mihwa; Li, Xiaohong (May 3, 2022). "RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice". Proceedings of the National Academy of Sciences of the United States of America. 119 (18): e2200128119. Bibcode:2022PNAS..11900128Z. doi:10.1073/pnas.2200128119. ISSN 1091-6490. PMC 9170173. PMID 35482923.
Zhong, Xue; Su, Lijing; Yang, Yi; Nair-Gill, Evan; Tang, Miao; Anderton, Priscilla; Li, Xiaohong; Wang, Jianhui; Zhan, Xiaoming; Tomchick, Diana R.; Brautigam, Chad A.; Moresco, Eva Marie Y.; Choi, Jin Huk; Beutler, Bruce (April 14, 2020). "Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function". Proceedings of the National Academy of Sciences of the United States of America. 117 (15): 8563–8572. Bibcode:2020PNAS..117.8563Z. doi:10.1073/pnas.2000703117. ISSN 1091-6490. PMC 7165429. PMID 32220963.
Misawa, Takuma; SoRelle, Jeffrey A.; Choi, Jin Huk; Yue, Tao; Wang, Kuan-Wen; McAlpine, William; Wang, Jianhui; Liu, Aijie; Tabeta, Koichi; Turer, Emre E.; Evers, Bret; Nair-Gill, Evan; Poddar, Subhajit; Su, Lijing; Ou, Feiya (January 24, 2020). "Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation". Science Immunology. 5 (43): eaaz0085. doi:10.1126/sciimmunol.aaz0085. ISSN 2470-9468. PMC 7278039. PMID 31980486.
Arnold, Carrie N.; Pirie, Elaine; Dosenovic, Pia; McInerney, Gerald M.; Xia, Yu; Wang, Nathaniel; Li, Xiaohong; Siggs, Owen M.; Karlsson Hedestam, Gunilla B.; Beutler, Bruce (July 31, 2012). "A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12286–12293. doi:10.1073/pnas.1209134109. ISSN 1091-6490. PMC 3411946. PMID 22761313.
Choi, Jin Huk; Wang, Kuan-Wen; Zhang, Duanwu; Zhan, Xiaowei; Wang, Tao; Bu, Chun-Hui; Behrendt, Cassie L.; Zeng, Ming; Wang, Ying; Misawa, Takuma; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Scott, Lindsay; Hildebrand, Sara (February 14, 2017). "IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1196 – E1204. Bibcode:2017PNAS..114E1196C. doi:10.1073/pnas.1621258114. ISSN 1091-6490. PMC 5321007. PMID 28137874.
Yue, Tao; Zhan, Xiaoming; Zhang, Duanwu; Jain, Ruchi; Wang, Kuan-Wen; Choi, Jin Huk; Misawa, Takuma; Su, Lijing; Quan, Jiexia; Hildebrand, Sara; Xu, Darui; Li, Xiaohong; Turer, Emre; Sun, Lei; Moresco, Eva Marie Y. (May 14, 2021). "SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity". Science. 372 (6543): eaba4220. doi:10.1126/science.aba4220. ISSN 1095-9203. PMC 8442736. PMID 33986151.
Nair-Gill, Evan; Bonora, Massimo; Zhong, Xue; Liu, Aijie; Miranda, Amber; Stewart, Nathan; Ludwig, Sara; Russell, Jamie; Gallagher, Thomas; Pinton, Paolo; Beutler, Bruce (May 3, 2021). "Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases". The EMBO Journal. 40 (9): e104888. doi:10.15252/embj.2020104888. ISSN 1460-2075. PMC 8090855. PMID 33630350.
Du, X.; She, E.; Gelbart, T.; Truksa, J.; Lee, P.; Xia, Y.; Khovananth, K.; Mudd, S.; Mann, N.; Moresco, E. M. Y.; Beutler, E.; Beutler, B. (2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. PMC 2430097. PMID 18451267.
Du, X.; Schwander, M.; Moresco, E. M. Y.; Viviani, P.; Haller, C.; Hildebrand, M. S.; Pak, K.; Tarantino, L.; Roberts, A.; Richardson, H.; Koob, G.; Najmabadi, H.; Ryan, A. F.; Smith, R. J. H.; Muller, U.; Beutler, B. (2008). "A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy of Sciences. 105 (38): 14609–14614. Bibcode:2008PNAS..10514609D. doi:10.1073/pnas.0807219105. PMC 2567147. PMID 18794526.
Blasius, Amanda L.; Brandl, Katharina; Crozat, Karine; Xia, Yu; Khovananth, Kevin; Krebs, Philippe; Smart, Nora G.; Zampolli, Antonella; Ruggeri, Zaverio M.; Beutler, Bruce A. (February 24, 2009). "Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2706–2711. Bibcode:2009PNAS..106.2706B. doi:10.1073/pnas.0813208106. ISSN 1091-6490. PMC 2650330. PMID 19202056.
Rutschmann, Sophie; Crozat, Karine; Li, Xiaohong; Du, Xin; Hanselman, Jeffrey C.; Shigeoka, Alana A.; Brandl, Katharina; Popkin, Daniel L.; McKay, Dianne B.; Xia, Yu; Moresco, Eva Marie Y.; Beutler, Bruce (April 2012). "Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice". G3: Genes, Genomes, Genetics. 2 (4): 499–504. doi:10.1534/g3.112.002196. ISSN 2160-1836. PMC 3337478. PMID 22540041.
Chen, Zhe; Holland, William; Shelton, John M.; Ali, Aktar; Zhan, Xiaoming; Won, Sungyong; Tomisato, Wataru; Liu, Chen; Li, Xiaohong; Moresco, Eva Marie Y.; Beutler, Bruce (May 20, 2014). "Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 111 (20): 7367–7372. Bibcode:2014PNAS..111.7367C. doi:10.1073/pnas.1406511111. ISSN 1091-6490. PMC 4034201. PMID 24799716.
Zhang, Zhao; Gallagher, Thomas; Scherer, Philipp E.; Beutler, Bruce (May 26, 2020). "Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome". Proceedings of the National Academy of Sciences of the United States of America. 117 (21): 11829–11835. Bibcode:2020PNAS..11711829Z. doi:10.1073/pnas.2000118117. ISSN 1091-6490. PMC 7260979. PMID 32381739.
Zhang, Zhao; Xun, Yu; Rong, Shunxing; Yan, Lijuan; SoRelle, Jeffrey A.; Li, Xiaohong; Tang, Miao; Keller, Katie; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (July 16, 2022). "Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity". Nature Communications. 13 (1): 4136. Bibcode:2022NatCo..13.4136Z. doi:10.1038/s41467-022-31812-4. ISSN 2041-1723. PMC 9288484. PMID 35842425.
Smyth, Ian; Du, Xin; Taylor, Martin S.; Justice, Monica J.; Beutler, Bruce; Jackson, Ian J. (September 14, 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13560–13565. Bibcode:2004PNAS..10113560S. doi:10.1073/pnas.0402760101. ISSN 0027-8424. PMC 518794. PMID 15345741.
Al-Fadhli, Fatima M.; Afqi, Manal; Sairafi, Mona Hamza; Almuntashri, Makki; Alharby, Essa; Alharbi, Ghadeer; Abdud Samad, Firoz; Hashmi, Jamil Amjad; Zaytuni, Dimah; Bahashwan, Ahmed A.; Choi, Jin Huk; Peake, Roy W. A.; Beutler, Bruce; Almontashiri, Naif A. M. (May 2021). "Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes". Clinical Genetics. 99 (5): 694–703. doi:10.1111/cge.13930. ISSN 1399-0004. PMID 33495992. S2CID 231710148.
Israel, Laura; Wang, Ying; Bulek, Katarzyna; Della Mina, Erika; Zhang, Zhao; Pedergnana, Vincent; Chrabieh, Maya; Lemmens, Nicole A.; Sancho-Shimizu, Vanessa; Descatoire, Marc; Lasseau, Théo; Israelsson, Elisabeth; Lorenzo, Lazaro; Yun, Ling; Belkadi, Aziz (February 23, 2017). "Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity". Cell. 168 (5): 789–800.e10. doi:10.1016/j.cell.2017.01.039. ISSN 1097-4172. PMC 5328639. PMID 28235196.
Melis, Maria Antonietta; Cau, Milena; Congiu, Rita; Sole, Gabriella; Barella, Susanna; Cao, Antonio; Westerman, Mark; Cazzola, Mario; Galanello, Renzo (October 2008). "A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron". Haematologica. 93 (10): 1473–1479. doi:10.3324/haematol.13342. ISSN 1592-8721. PMID 18603562. S2CID 23364362.
El Hayek, Lauretta; Tuncay, Islam Oguz; Nijem, Nadine; Russell, Jamie; Ludwig, Sara; Kaur, Kiran; Li, Xiaohong; Anderton, Priscilla; Tang, Miao; Gerard, Amanda; Heinze, Anja; Zacher, Pia; Alsaif, Hessa S.; Rad, Aboulfazl; Hassanpour, Kazem (December 22, 2020). "KDM5A mutations identified in autism spectrum disorder using forward genetics". eLife. 9: e56883. doi:10.7554/eLife.56883. ISSN 2050-084X. PMC 7755391. PMID 33350388.
Rios, Jonathan J.; Denton, Kristin; Yu, Hao; Manickam, Kandamurugu; Garner, Shannon; Russell, Jamie; Ludwig, Sara; Rosenfeld, Jill A.; Liu, Pengfei; Munch, Jake; Sucato, Daniel J.; Beutler, Bruce; Wise, Carol A. (June 1, 2021). "Saturation mutagenesis defines novel mouse models of severe spine deformity". Disease Models & Mechanisms. 14 (6): dmm048901. doi:10.1242/dmm.048901. ISSN 1754-8411. PMC 8246263. PMID 34142127.
Rios, Jonathan J.; Denton, Kristin; Russell, Jamie; Kozlitina, Julia; Ferreira, Carlos R.; Lewanda, Amy F.; Mayfield, Joshua E.; Moresco, Eva; Ludwig, Sara; Tang, Miao; Li, Xiaohong; Lyon, Stephen; Khanshour, Anas; Paria, Nandina; Khalid, Aysha (August 2021). "Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice". Journal of Bone and Mineral Research. 36 (8): 1548–1565. doi:10.1002/jbmr.4323. ISSN 1523-4681. PMC 8862308. PMID 33905568.
Andrews, T. D.; Whittle, B.; Field, M. A.; Balakishnan, B.; Zhang, Y.; Shao, Y.; Cho, V.; Kirk, M.; Singh, M.; Xia, Y.; Hager, J.; Winslade, S.; Sjollema, G.; Beutler, B.; Enders, A. (May 2012). "Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models". Open Biology. 2 (5): 120061. doi:10.1098/rsob.120061. ISSN 2046-2441. PMC 3376740. PMID 22724066.
Bull, Katherine R.; Rimmer, Andrew J.; Siggs, Owen M.; Miosge, Lisa A.; Roots, Carla M.; Enders, Anselm; Bertram, Edward M.; Crockford, Tanya L.; Whittle, Belinda; Potter, Paul K.; Simon, Michelle M.; Mallon, Ann-Marie; Brown, Steve D. M.; Beutler, Bruce; Goodnow, Christopher C. (2013). "Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations". PLOS Genetics. 9 (1): e1003219. doi:10.1371/journal.pgen.1003219. ISSN 1553-7404. PMC 3561070. PMID 23382690.
Xia, Yu; Won, Sungyong; Du, Xin; Lin, Pei; Ross, Charles; La Vine, Diantha; Wiltshire, Sean; Leiva, Gabriel; Vidal, Silvia M.; Whittle, Belinda; Goodnow, Christopher C.; Koziol, James; Moresco, Eva Marie Y.; Beutler, Bruce (December 2010). "Bulk segregation mapping of mutations in closely related strains of mice". Genetics. 186 (4): 1139–1146. doi:10.1534/genetics.110.121160. ISSN 1943-2631. PMC 2998299. PMID 20923982.
Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Lyon, Stephen; Pratt, David; Hildebrand, Sara; Choi, Jin Huk; Zhang, Zhao; Zeng, Ming; Wang, Kuan-wen; Turer, Emre; Chen, Zhe; Zhang, Duanwu; Yue, Tao; Wang, Ying (February 3, 2015). "Real-time resolution of point mutations that cause phenovariance in mice". Proceedings of the National Academy of Sciences of the United States of America. 112 (5): E440–449. Bibcode:2015PNAS..112E.440W. doi:10.1073/pnas.1423216112. ISSN 1091-6490. PMC 4321302. PMID 25605905.
Wang, Tao; Bu, Chun Hui; Hildebrand, Sara; Jia, Gaoxiang; Siggs, Owen M.; Lyon, Stephen; Pratt, David; Scott, Lindsay; Russell, Jamie; Ludwig, Sara; Murray, Anne R.; Moresco, Eva Marie Y.; Beutler, Bruce (January 30, 2018). "Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database". Nature Communications. 9 (1): 441. Bibcode:2018NatCo...9..441W. doi:10.1038/s41467-017-02806-4. ISSN 2041-1723. PMC 5789985. PMID 29382827.
Xu, Darui; Lyon, Stephen; Bu, Chun Hui; Hildebrand, Sara; Choi, Jin Huk; Zhong, Xue; Liu, Aijie; Turer, Emre E.; Zhang, Zhao; Russell, Jamie; Ludwig, Sara; Mahrt, Elena; Nair-Gill, Evan; Shi, Hexin; Wang, Ying (July 13, 2021). "Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning". Proceedings of the National Academy of Sciences of the United States of America. 118 (28): e2106786118. Bibcode:2021PNAS..11806786X. doi:10.1073/pnas.2106786118. ISSN 1091-6490. PMC 8285956. PMID 34260399.
Chen, Bo; Aredo, Bogale; Ding, Yi; Zhong, Xin; Zhu, Yuanfei; Zhao, Cynthia X.; Kumar, Ashwani; Xing, Chao; Gautron, Laurent; Lyon, Stephen; Russell, Jamie; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Ludwig, Sara (June 9, 2020). "Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 12931–12942. Bibcode:2020PNAS..11712931C. doi:10.1073/pnas.1921224117. ISSN 1091-6490. PMC 7293615. PMID 32457148.
Wang, Yibing; Cao, Liqin; Lee, Chia-Ying; Matsuo, Tomohiko; Wu, Kejia; Asher, Greg; Tang, Lijun; Saitoh, Tsuyoshi; Russell, Jamie; Klewe-Nebenius, Daniela; Wang, Li; Soya, Shingo; Hasegawa, Emi; Chérasse, Yoan; Zhou, Jiamin (May 23, 2018). "Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors". Nature Communications. 9 (1): 2041. Bibcode:2018NatCo...9.2041W. doi:10.1038/s41467-018-04324-3. ISSN 2041-1723. PMC 5966455. PMID 29795268.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Mifune, Yuto; Su, Lijing; Shi, Hexin; Moresco, Eva Marie Y.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (October 31, 2018). "Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists". Journal of the American Chemical Society. 140 (43): 14440–14454. doi:10.1021/jacs.8b09223. ISSN 1520-5126. PMC 6209530. PMID 30272974.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Su, Lijing; Surakattula, Murali M. R. P.; Berger, Michael; Huang, Hua; Beutler, Elliot K.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (May 26, 2016). "Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists". Journal of Medicinal Chemistry. 59 (10): 4812–4830. doi:10.1021/acs.jmedchem.6b00177. ISSN 1520-4804. PMC 4882283. PMID 27050713.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Mifune, Yuto; Shi, Hexin; Wang, Kuan-Wen; Zhan, Xiaoming; Liu, Aijie; Wang, Jianhui; Li, Xiaohong; Tang, Miao; Ludwig, Sara; Hildebrand, Sara; Zhou, Kejin (September 11, 2018). "Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice". Proceedings of the National Academy of Sciences of the United States of America. 115 (37): E8698 – E8706. Bibcode:2018PNAS..115E8698W. doi:10.1073/pnas.1809232115. ISSN 1091-6490. PMC 6140543. PMID 30150374.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Whitby, Landon R.; Surakattula, Murali M. R. P.; Huang, Hua; Shi, Hexin; Choi, Jin Huk; Wang, Kuan-wen; Moresco, Eva Marie Y.; Berger, Michael; Zhan, Xiaoming; Zhang, Hong; Boger, Dale L. (February 16, 2016). "TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS". Proceedings of the National Academy of Sciences of the United States of America. 113 (7): E884–893. Bibcode:2016PNAS..113E.884W. doi:10.1073/pnas.1525639113. ISSN 1091-6490. PMC 4763747. PMID 26831104.
Su, Lijing; Athamna, Muhammad; Wang, Ying; Wang, Junmei; Freudenberg, Marina; Yue, Tao; Wang, Jianhui; Moresco, Eva Marie Y.; He, Haoming; Zor, Tsaffrir; Beutler, Bruce (July 27, 2021). "Sulfatides are endogenous ligands for the TLR4-MD-2 complex". Proceedings of the National Academy of Sciences of the United States of America. 118 (30): e2105316118. Bibcode:2021PNAS..11805316S. doi:10.1073/pnas.2105316118. ISSN 1091-6490. PMC 8325290. PMID 34290146.
Su, Lijing; Wang, Ying; Wang, Junmei; Mifune, Yuto; Morin, Matthew D.; Jones, Brian T.; Moresco, Eva Marie Y.; Boger, Dale L.; Beutler, Bruce; Zhang, Hong (March 28, 2019). "Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim". Journal of Medicinal Chemistry. 62 (6): 2938–2949. doi:10.1021/acs.jmedchem.8b01583. ISSN 1520-4804. PMC 6537610. PMID 30829478.
Yang, Ming-Hsiu; Russell, Jamie L.; Mifune, Yuto; Wang, Ying; Shi, Hexin; Moresco, Eva Marie Y.; Siegwart, Daniel J.; Beutler, Bruce; Boger, Dale L. (July 14, 2022). "Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response". Journal of Medicinal Chemistry. 65 (13): 9230–9252. doi:10.1021/acs.jmedchem.2c00419. ISSN 1520-4804. PMC 9283309. PMID 35767437.
Beutler, Bruce (January 1, 2009). "Ernest Beutler (1928–2008)". Haematologica. 94 (1): 154–156. doi:10.3324/haematol.13863. ISSN 1592-8721. PMC 2625414. PMID 19118377. S2CID 43531611.
Beutler, E. (February 1959). "The hemolytic effect of primaquine and related compounds: a review". Blood. 14 (2): 103–139. doi:10.1182/blood.V14.2.103.103. ISSN 0006-4971. PMID 13618370.
Beutler, Ernest (July 2006). "Lysosomal storage diseases: natural history and ethical and economic aspects". Molecular Genetics and Metabolism. 88 (3): 208–215. doi:10.1016/j.ymgme.2006.01.010. ISSN 1096-7192. PMID 16515872.
Beutler, E.; Blume, K. G.; Bross, K. J.; Chillar, R. K.; Ellington, O. B.; Fahey, J. L.; Farbstein, M. J.; Schmidt, G. M.; Spruce, W. E.; Turner, M. A. (1979). "Bone marrow transplantation as the treatment of choice for "good risk" adult patients with acute leukemia". Transactions of the Association of American Physicians. 92: 189–195. ISSN 0066-9458. PMID 398617.
Piro, L. D.; Carrera, C. J.; Carson, D. A.; Beutler, E. (April 19, 1990). "Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine". The New England Journal of Medicine. 322 (16): 1117–1121. doi:10.1056/NEJM199004193221605. ISSN 0028-4793. PMID 1969613.
Beutler, E.; Yeh, M.; Fairbanks, V. F. (January 15, 1962). "The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker". Proceedings of the National Academy of Sciences of the United States of America. 48 (1): 9–16. Bibcode:1962PNAS...48....9B. doi:10.1073/pnas.48.1.9. ISSN 0027-8424. PMC 285481. PMID 13868717.
Beutler, Bruce; Beutler, Ernest (December 12, 2002). "Toll-like receptor 4 polymorphisms and atherogenesis". The New England Journal of Medicine. 347 (24): 1978–1980, author reply 1978–1980. doi:10.1056/NEJM200212123472416. ISSN 1533-4406. PMID 12479194.
Beutler, E.; Gelbart, T.; Han, J. H.; Koziol, J. A.; Beutler, B. (January 1989). "Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage". Proceedings of the National Academy of Sciences of the United States of America. 86 (1): 192–196. Bibcode:1989PNAS...86..192B. doi:10.1073/pnas.86.1.192. ISSN 0027-8424. PMC 286430. PMID 2463621.
Truksa, Jaroslav; Gelbart, Terri; Peng, Hongfan; Beutler, Ernest; Beutler, Bruce; Lee, Pauline (November 2009). "Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6". British Journal of Haematology. 147 (4): 571–581. doi:10.1111/j.1365-2141.2009.07873.x. ISSN 1365-2141. PMID 19751239. S2CID 205266224.
Du, Xin; She, Ellen; Gelbart, Terri; Truksa, Jaroslav; Lee, Pauline; Xia, Yu; Khovananth, Kevin; Mudd, Suzanne; Mann, Navjiwan; Moresco, Eva Marie Y.; Beutler, Ernest; Beutler, Bruce (May 23, 2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. ISSN 1095-9203. PMC 2430097. PMID 18451267.

ncbi.nlm.nih.gov

Ravindran, S. (2013). "Profile of Bruce A. Beutler". Proceedings of the National Academy of Sciences. 110 (32): 12857–8. Bibcode:2013PNAS..11012857R. doi:10.1073/pnas.1311624110. PMC 3740904. PMID 23858464.
Beutler, B.; Mahoney, J.; Le Trang, N.; Pekala, P.; Cerami, A. (May 1, 1985). "Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells". The Journal of Experimental Medicine. 161 (5): 984–995. doi:10.1084/jem.161.5.984. ISSN 0022-1007. PMC 2187615. PMID 3872925.
Dayer, J. M.; Beutler, B.; Cerami, A. (December 1, 1985). "Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts". The Journal of Experimental Medicine. 162 (6): 2163–2168. doi:10.1084/jem.162.6.2163. ISSN 0022-1007. PMC 2187983. PMID 2999289.
Nophar, Y.; Kemper, O.; Brakebusch, C.; Englemann, H.; Zwang, R.; Aderka, D.; Holtmann, H.; Wallach, D. (October 1, 1990). "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor". The EMBO Journal. 9 (10): 3269–3278. doi:10.1002/j.1460-2075.1990.tb07526.x. ISSN 0261-4189. PMC 552060. PMID 1698610.
Peppel, K.; Crawford, D.; Beutler, B. (December 1, 1991). "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity". The Journal of Experimental Medicine. 174 (6): 1483–1489. doi:10.1084/jem.174.6.1483. ISSN 0022-1007. PMC 2119031. PMID 1660525.
Johnson, A. G.; Gaines, S.; Landy, M. (February 1, 1956). "Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide". The Journal of Experimental Medicine. 103 (2): 225–246. doi:10.1084/jem.103.2.225. ISSN 0022-1007. PMC 2136584. PMID 13286429.
Watson, J.; Riblet, R. (November 1, 1974). "Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic respones [sic] to lipopolysaccharides". The Journal of Experimental Medicine. 140 (5): 1147–1161. doi:10.1084/jem.140.5.1147. ISSN 0022-1007. PMC 2139714. PMID 4138849.
Poltorak, A.; Ricciardi-Castagnoli, P.; Citterio, S.; Beutler, B. (February 29, 2000). "Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2163–2167. Bibcode:2000PNAS...97.2163P. doi:10.1073/pnas.040565397. ISSN 0027-8424. PMC 15771. PMID 10681462.
Shimazu, R.; Akashi, S.; Ogata, H.; Nagai, Y.; Fukudome, K.; Miyake, K.; Kimoto, M. (June 7, 1999). "MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4". The Journal of Experimental Medicine. 189 (11): 1777–1782. doi:10.1084/jem.189.11.1777. ISSN 0022-1007. PMC 2193086. PMID 10359581.
Kirschning, C. J.; Wesche, H.; Merrill Ayres, T.; Rothe, M. (December 7, 1998). "Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide". The Journal of Experimental Medicine. 188 (11): 2091–2097. doi:10.1084/jem.188.11.2091. ISSN 0022-1007. PMC 2212382. PMID 9841923.
Brown, Grant J.; Cañete, Pablo F.; Wang, Hao; Medhavy, Arti; Bones, Josiah; Roco, Jonathan A.; He, Yuke; Qin, Yuting; Cappello, Jean; Ellyard, Julia I.; Bassett, Katharine; Shen, Qian; Burgio, Gaetan; Zhang, Yaoyuan; Turnbull, Cynthia (May 2022). "TLR7 gain-of-function genetic variation causes human lupus". Nature. 605 (7909): 349–356. Bibcode:2022Natur.605..349B. doi:10.1038/s41586-022-04642-z. ISSN 1476-4687. PMC 9095492. PMID 35477763.
Leibler, Claire; John, Shinu; Elsner, Rebecca A.; Thomas, Kayla B.; Smita, Shuchi; Joachim, Stephen; Levack, Russell C.; Callahan, Derrick J.; Gordon, Rachael A.; Bastacky, Sheldon; Fukui, Ryutaro; Miyake, Kensuke; Gingras, Sebastien; Nickerson, Kevin M.; Shlomchik, Mark J. (October 2022). "Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus". Nature Immunology. 23 (10): 1457–1469. doi:10.1038/s41590-022-01310-2. ISSN 1529-2916. PMC 9561083. PMID 36151396.
Baccala, Roberto; Gonzalez-Quintial, Rosana; Blasius, Amanda L.; Rimann, Ivo; Ozato, Keiko; Kono, Dwight H.; Beutler, Bruce; Theofilopoulos, Argyrios N. (February 19, 2013). "Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus". Proceedings of the National Academy of Sciences of the United States of America. 110 (8): 2940–2945. Bibcode:2013PNAS..110.2940B. doi:10.1073/pnas.1222798110. ISSN 1091-6490. PMC 3581947. PMID 23382217.
Kono, Dwight H.; Haraldsson, M. Katarina; Lawson, Brian R.; Pollard, K. Michael; Koh, Yi Ting; Du, Xin; Arnold, Carrie N.; Baccala, Roberto; Silverman, Gregg J.; Beutler, Bruce A.; Theofilopoulos, Argyrios N. (July 21, 2009). "Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus". Proceedings of the National Academy of Sciences of the United States of America. 106 (29): 12061–12066. Bibcode:2009PNAS..10612061K. doi:10.1073/pnas.0905441106. ISSN 1091-6490. PMC 2715524. PMID 19574451.
Lau, Christina M.; Broughton, Courtney; Tabor, Abigail S.; Akira, Shizuo; Flavell, Richard A.; Mamula, Mark J.; Christensen, Sean R.; Shlomchik, Mark J.; Viglianti, Gregory A.; Rifkin, Ian R.; Marshak-Rothstein, Ann (November 7, 2005). "RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement". The Journal of Experimental Medicine. 202 (9): 1171–1177. doi:10.1084/jem.20050630. ISSN 0022-1007. PMC 2213226. PMID 16260486.
Croker, Ben A.; Lawson, Brian R.; Rutschmann, Sophie; Berger, Michael; Eidenschenk, Celine; Blasius, Amanda L.; Moresco, Eva Marie Y.; Sovath, Sosathya; Cengia, Louise; Shultz, Leonard D.; Theofilopoulos, Argyrios N.; Pettersson, Sven; Beutler, Bruce Alan (September 30, 2008). "Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger". Proceedings of the National Academy of Sciences of the United States of America. 105 (39): 15028–15033. Bibcode:2008PNAS..10515028C. doi:10.1073/pnas.0806619105. ISSN 1091-6490. PMC 2567487. PMID 18806225.
Shi, Hexin; Wang, Ying; Li, Xiaohong; Zhan, Xiaoming; Tang, Miao; Fina, Maggy; Su, Lijing; Pratt, David; Bu, Chun Hui; Hildebrand, Sara; Lyon, Stephen; Scott, Lindsay; Quan, Jiexia; Sun, Qihua; Russell, Jamie (December 7, 2015). "NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component". Nature Immunology. 17 (3): 250–258. doi:10.1038/ni.3333. ISSN 1529-2916. PMC 4862588. PMID 26642356.
Sun, Lei; Jiang, Zhengfan; Acosta-Rodriguez, Victoria A.; Berger, Michael; Du, Xin; Choi, Jin Huk; Wang, Jianhui; Wang, Kuan-Wen; Kilaru, Gokhul K.; Mohawk, Jennifer A.; Quan, Jiexia; Scott, Lindsay; Hildebrand, Sara; Li, Xiaohong; Tang, Miao (November 6, 2017). "HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections". The Journal of Experimental Medicine. 214 (11): 3263–3277. doi:10.1084/jem.20161630. ISSN 1540-9538. PMC 5679162. PMID 28970238.
Shi, Hexin; Sun, Lei; Wang, Ying; Liu, Aijie; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Hildebrand, Sara; Quan, Jiexia; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (March 2, 2021). "N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization". Nature Communications. 12 (1): 1379. Bibcode:2021NatCo..12.1379S. doi:10.1038/s41467-021-21711-5. ISSN 2041-1723. PMC 7925594. PMID 33654074.
Blasius, Amanda L.; Arnold, Carrie N.; Georgel, Philippe; Rutschmann, Sophie; Xia, Yu; Lin, Pei; Ross, Charles; Li, Xiaohong; Smart, Nora G.; Beutler, Bruce (November 16, 2010). "Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19973–19978. Bibcode:2010PNAS..10719973B. doi:10.1073/pnas.1014051107. ISSN 1091-6490. PMC 2993408. PMID 21045126.
Brandl, Katharina; Rutschmann, Sophie; Li, Xiaohong; Du, Xin; Xiao, Nengming; Schnabl, Bernd; Brenner, David A.; Beutler, Bruce (March 3, 2009). "Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3300–3305. Bibcode:2009PNAS..106.3300B. doi:10.1073/pnas.0813036106. ISSN 1091-6490. PMC 2651297. PMID 19202076.
Brandl, Katharina; Sun, Lei; Neppl, Christina; Siggs, Owen M.; Le Gall, Sylvain M.; Tomisato, Wataru; Li, Xiaohong; Du, Xin; Maennel, Daniela N.; Blobel, Carl P.; Beutler, Bruce (November 16, 2010). "MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19967–19972. Bibcode:2010PNAS..10719967B. doi:10.1073/pnas.1014669107. ISSN 1091-6490. PMC 2993336. PMID 21041656.
Brandl, Katharina; Tomisato, Wataru; Li, Xiaohong; Neppl, Christina; Pirie, Elaine; Falk, Werner; Xia, Yu; Moresco, Eva Marie Y.; Baccala, Roberto; Theofilopoulos, Argyrios N.; Schnabl, Bernd; Beutler, Bruce (July 31, 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12650–12655. Bibcode:2012PNAS..10912650B. doi:10.1073/pnas.1210366109. ISSN 1091-6490. PMC 3412000. PMID 22802641.
McAlpine, William; Sun, Lei; Wang, Kuan-Wen; Liu, Aijie; Jain, Ruchi; San Miguel, Miguel; Wang, Jianhui; Zhang, Zhao; Hayse, Braden; McAlpine, Sarah Grace; Choi, Jin Huk; Zhong, Xue; Ludwig, Sara; Russell, Jamie; Zhan, Xiaoming (December 4, 2018). "Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function". Proceedings of the National Academy of Sciences of the United States of America. 115 (49): E11523 – E11531. Bibcode:2018PNAS..11511523M. doi:10.1073/pnas.1814753115. ISSN 1091-6490. PMC 6298088. PMID 30442666.
McAlpine, William; Wang, Kuan-Wen; Choi, Jin Huk; San Miguel, Miguel; McAlpine, Sarah Grace; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao; Bu, Chun Hui; Murray, Anne R.; Moresco, Eva Marie Y. (September 27, 2018). "The class I myosin MYO1D binds to lipid and protects against colitis". Disease Models & Mechanisms. 11 (9): dmm035923. doi:10.1242/dmm.035923. ISSN 1754-8411. PMC 6176994. PMID 30279225.
Wang, Kuan-Wen; Zhan, Xiaoming; McAlpine, William; Zhang, Zhao; Choi, Jin Huk; Shi, Hexin; Misawa, Takuma; Yue, Tao; Zhang, Duanwu; Wang, Ying; Ludwig, Sara; Russell, Jamie; Tang, Miao; Li, Xiaohong; Murray, Anne R. (June 4, 2019). "Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice". Proceedings of the National Academy of Sciences of the United States of America. 116 (23): 11380–11389. Bibcode:2019PNAS..11611380W. doi:10.1073/pnas.1901407116. ISSN 1091-6490. PMC 6561264. PMID 31097594.
Turer, Emre; McAlpine, William; Wang, Kuan-Wen; Lu, Tianshi; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Murray, Anne R.; Beutler, Bruce (February 14, 2017). "Creatine maintains intestinal homeostasis and protects against colitis". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1273 – E1281. Bibcode:2017PNAS..114E1273T. doi:10.1073/pnas.1621400114. ISSN 1091-6490. PMC 5321020. PMID 28137860.
SoRelle, Jeffrey A.; Chen, Zhe; Wang, Jianhui; Yue, Tao; Choi, Jin Huk; Wang, Kuan-Wen; Zhong, Xue; Hildebrand, Sara; Russell, Jamie; Scott, Lindsay; Xu, Darui; Zhan, Xiaowei; Bu, Chun Hui; Wang, Tao; Choi, Mihwa (April 2021). "Dominant atopy risk mutations identified by mouse forward genetic analysis". Allergy. 76 (4): 1095–1108. doi:10.1111/all.14564. ISSN 1398-9995. PMC 7889751. PMID 32810290.
Chatenoud, Lucienne; Marquet, Cindy; Valette, Fabrice; Scott, Lindsay; Quan, Jiexia; Bu, Chun Hui; Hildebrand, Sara; Moresco, Eva Marie Y.; Bach, Jean-François; Beutler, Bruce (June 1, 2022). "Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice". Disease Models & Mechanisms. 15 (6): dmm049484. doi:10.1242/dmm.049484. ISSN 1754-8411. PMC 9178510. PMID 35502705.
Foray, Anne-Perrine; Candon, Sophie; Hildebrand, Sara; Marquet, Cindy; Valette, Fabrice; Pecquet, Coralie; Lemoine, Sebastien; Langa-Vives, Francina; Dumas, Michael; Hu, Peipei; Santamaria, Pere; You, Sylvaine; Lyon, Stephen; Scott, Lindsay; Bu, Chun Hui (November 23, 2021). "De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes". Proceedings of the National Academy of Sciences of the United States of America. 118 (47): e2112032118. Bibcode:2021PNAS..11812032F. doi:10.1073/pnas.2112032118. ISSN 1091-6490. PMC 8617500. PMID 34782469.
Zhang, Zhao; Turer, Emre; Li, Xiaohong; Zhan, Xiaoming; Choi, Mihwa; Tang, Miao; Press, Amanda; Smith, Steven R.; Divoux, Adeline; Moresco, Eva Marie Y.; Beutler, Bruce (October 18, 2016). "Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice". Proceedings of the National Academy of Sciences of the United States of America. 113 (42): E6418 – E6426. Bibcode:2016PNAS..113E6418Z. doi:10.1073/pnas.1614467113. ISSN 1091-6490. PMC 5081616. PMID 27708159.
Turer, Emre E.; San Miguel, Miguel; Wang, Kuan-Wen; McAlpine, William; Ou, Feiya; Li, Xiaohong; Tang, Miao; Zang, Zhao; Wang, Jianhui; Hayse, Braden; Evers, Bret; Zhan, Xiaoming; Russell, Jamie; Beutler, Bruce (December 18, 2018). "A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis". Disease Models & Mechanisms. 11 (12): dmm035451. doi:10.1242/dmm.035451. ISSN 1754-8411. PMC 6307907. PMID 30563851.
Zhang, Zhao; Jiang, Yiao; Su, Lijing; Ludwig, Sara; Zhang, Xuechun; Tang, Miao; Li, Xiaohong; Anderton, Priscilla; Zhan, Xiaoming; Choi, Mihwa; Russell, Jamie; Bu, Chun-Hui; Lyon, Stephen; Xu, Darui; Hildebrand, Sara (November 1, 2022). "Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis". Cell Metabolism. 34 (11): 1860–1874.e4. doi:10.1016/j.cmet.2022.09.018. ISSN 1932-7420. PMC 9633419. PMID 36228616.
Berger, Michael; Krebs, Philippe; Crozat, Karine; Li, Xiaohong; Croker, Ben A.; Siggs, Owen M.; Popkin, Daniel; Du, Xin; Lawson, Brian R.; Theofilopoulos, Argyrios N.; Xia, Yu; Khovananth, Kevin; Moresco, Eva Marie; Satoh, Takashi; Takeuchi, Osamu (April 2010). "An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence". Nature Immunology. 11 (4): 335–343. doi:10.1038/ni.1847. ISSN 1529-2916. PMC 2861894. PMID 20190759.
Siggs, Owen M.; Arnold, Carrie N.; Huber, Christoph; Pirie, Elaine; Xia, Yu; Lin, Pei; Nemazee, David; Beutler, Bruce (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–440. doi:10.1038/ni.2012. ISSN 1529-2916. PMC 3079768. PMID 21423172.
Siggs, Owen M.; Li, Xiaohong; Xia, Yu; Beutler, Bruce (January 16, 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. ISSN 1540-9538. PMC 3260866. PMID 22201126.
Choi, Jin Huk; Han, Jonghee; Theodoropoulos, Panayotis C.; Zhong, Xue; Wang, Jianhui; Medler, Dawson; Ludwig, Sara; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Gallagher, Thomas; Yu, Gang; Beutler, Bruce (March 3, 2020). "Essential requirement for nicastrin in marginal zone and B-1 B cell development". Proceedings of the National Academy of Sciences of the United States of America. 117 (9): 4894–4901. Bibcode:2020PNAS..117.4894C. doi:10.1073/pnas.1916645117. ISSN 1091-6490. PMC 7060662. PMID 32071239.
Choi, Jin Huk; Zhong, Xue; McAlpine, William; Liao, Tzu-Chieh; Zhang, Duanwu; Fang, Beibei; Russell, Jamie; Ludwig, Sara; Nair-Gill, Evan; Zhang, Zhao; Wang, Kuan-Wen; Misawa, Takuma; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao (May 10, 2019). "LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling". Science. 364 (6440): eaau0812. doi:10.1126/science.aau0812. ISSN 1095-9203. PMC 7206793. PMID 31073040.
Choi, Jin Huk; Zhong, Xue; Zhang, Zhao; Su, Lijing; McAlpine, William; Misawa, Takuma; Liao, Tzu-Chieh; Zhan, Xiaoming; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Moresco, Eva Marie Y.; Beutler, Bruce (April 6, 2020). "Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development". The Journal of Experimental Medicine. 217 (4): e20190006. doi:10.1084/jem.20190006. ISSN 1540-9538. PMC 7144532. PMID 31985756.
Zhang, Duanwu; Yue, Tao; Choi, Jin Huk; Nair-Gill, Evan; Zhong, Xue; Wang, Kuan-Wen; Zhan, Xiaoming; Li, Xiaohong; Choi, Mihwa; Tang, Miao; Quan, Jiexia; Hildebrand, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (October 2019). "Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40". Nature Immunology. 20 (10): 1322–1334. doi:10.1038/s41590-019-0464-4. ISSN 1529-2916. PMC 7179765. PMID 31427773.
Zhong, Xue; Choi, Jin Huk; Hildebrand, Sara; Ludwig, Sara; Wang, Jianhui; Nair-Gill, Evan; Liao, Tzu-Chieh; Moresco, James J.; Liu, Aijie; Quan, Jiexia; Sun, Qihua; Zhang, Duanwu; Zhan, Xiaoming; Choi, Mihwa; Li, Xiaohong (May 3, 2022). "RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice". Proceedings of the National Academy of Sciences of the United States of America. 119 (18): e2200128119. Bibcode:2022PNAS..11900128Z. doi:10.1073/pnas.2200128119. ISSN 1091-6490. PMC 9170173. PMID 35482923.
Zhong, Xue; Su, Lijing; Yang, Yi; Nair-Gill, Evan; Tang, Miao; Anderton, Priscilla; Li, Xiaohong; Wang, Jianhui; Zhan, Xiaoming; Tomchick, Diana R.; Brautigam, Chad A.; Moresco, Eva Marie Y.; Choi, Jin Huk; Beutler, Bruce (April 14, 2020). "Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function". Proceedings of the National Academy of Sciences of the United States of America. 117 (15): 8563–8572. Bibcode:2020PNAS..117.8563Z. doi:10.1073/pnas.2000703117. ISSN 1091-6490. PMC 7165429. PMID 32220963.
Misawa, Takuma; SoRelle, Jeffrey A.; Choi, Jin Huk; Yue, Tao; Wang, Kuan-Wen; McAlpine, William; Wang, Jianhui; Liu, Aijie; Tabeta, Koichi; Turer, Emre E.; Evers, Bret; Nair-Gill, Evan; Poddar, Subhajit; Su, Lijing; Ou, Feiya (January 24, 2020). "Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation". Science Immunology. 5 (43): eaaz0085. doi:10.1126/sciimmunol.aaz0085. ISSN 2470-9468. PMC 7278039. PMID 31980486.
Arnold, Carrie N.; Pirie, Elaine; Dosenovic, Pia; McInerney, Gerald M.; Xia, Yu; Wang, Nathaniel; Li, Xiaohong; Siggs, Owen M.; Karlsson Hedestam, Gunilla B.; Beutler, Bruce (July 31, 2012). "A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12286–12293. doi:10.1073/pnas.1209134109. ISSN 1091-6490. PMC 3411946. PMID 22761313.
Choi, Jin Huk; Wang, Kuan-Wen; Zhang, Duanwu; Zhan, Xiaowei; Wang, Tao; Bu, Chun-Hui; Behrendt, Cassie L.; Zeng, Ming; Wang, Ying; Misawa, Takuma; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Scott, Lindsay; Hildebrand, Sara (February 14, 2017). "IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1196 – E1204. Bibcode:2017PNAS..114E1196C. doi:10.1073/pnas.1621258114. ISSN 1091-6490. PMC 5321007. PMID 28137874.
Yue, Tao; Zhan, Xiaoming; Zhang, Duanwu; Jain, Ruchi; Wang, Kuan-Wen; Choi, Jin Huk; Misawa, Takuma; Su, Lijing; Quan, Jiexia; Hildebrand, Sara; Xu, Darui; Li, Xiaohong; Turer, Emre; Sun, Lei; Moresco, Eva Marie Y. (May 14, 2021). "SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity". Science. 372 (6543): eaba4220. doi:10.1126/science.aba4220. ISSN 1095-9203. PMC 8442736. PMID 33986151.
Nair-Gill, Evan; Bonora, Massimo; Zhong, Xue; Liu, Aijie; Miranda, Amber; Stewart, Nathan; Ludwig, Sara; Russell, Jamie; Gallagher, Thomas; Pinton, Paolo; Beutler, Bruce (May 3, 2021). "Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases". The EMBO Journal. 40 (9): e104888. doi:10.15252/embj.2020104888. ISSN 1460-2075. PMC 8090855. PMID 33630350.
Du, X.; She, E.; Gelbart, T.; Truksa, J.; Lee, P.; Xia, Y.; Khovananth, K.; Mudd, S.; Mann, N.; Moresco, E. M. Y.; Beutler, E.; Beutler, B. (2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. PMC 2430097. PMID 18451267.
Du, X.; Schwander, M.; Moresco, E. M. Y.; Viviani, P.; Haller, C.; Hildebrand, M. S.; Pak, K.; Tarantino, L.; Roberts, A.; Richardson, H.; Koob, G.; Najmabadi, H.; Ryan, A. F.; Smith, R. J. H.; Muller, U.; Beutler, B. (2008). "A catechol-O-methyltransferase that is essential for auditory function in mice and humans". Proceedings of the National Academy of Sciences. 105 (38): 14609–14614. Bibcode:2008PNAS..10514609D. doi:10.1073/pnas.0807219105. PMC 2567147. PMID 18794526.
Blasius, Amanda L.; Brandl, Katharina; Crozat, Karine; Xia, Yu; Khovananth, Kevin; Krebs, Philippe; Smart, Nora G.; Zampolli, Antonella; Ruggeri, Zaverio M.; Beutler, Bruce A. (February 24, 2009). "Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2706–2711. Bibcode:2009PNAS..106.2706B. doi:10.1073/pnas.0813208106. ISSN 1091-6490. PMC 2650330. PMID 19202056.
Rutschmann, Sophie; Crozat, Karine; Li, Xiaohong; Du, Xin; Hanselman, Jeffrey C.; Shigeoka, Alana A.; Brandl, Katharina; Popkin, Daniel L.; McKay, Dianne B.; Xia, Yu; Moresco, Eva Marie Y.; Beutler, Bruce (April 2012). "Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice". G3: Genes, Genomes, Genetics. 2 (4): 499–504. doi:10.1534/g3.112.002196. ISSN 2160-1836. PMC 3337478. PMID 22540041.
Chen, Zhe; Holland, William; Shelton, John M.; Ali, Aktar; Zhan, Xiaoming; Won, Sungyong; Tomisato, Wataru; Liu, Chen; Li, Xiaohong; Moresco, Eva Marie Y.; Beutler, Bruce (May 20, 2014). "Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 111 (20): 7367–7372. Bibcode:2014PNAS..111.7367C. doi:10.1073/pnas.1406511111. ISSN 1091-6490. PMC 4034201. PMID 24799716.
Zhang, Zhao; Gallagher, Thomas; Scherer, Philipp E.; Beutler, Bruce (May 26, 2020). "Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome". Proceedings of the National Academy of Sciences of the United States of America. 117 (21): 11829–11835. Bibcode:2020PNAS..11711829Z. doi:10.1073/pnas.2000118117. ISSN 1091-6490. PMC 7260979. PMID 32381739.
Zhang, Zhao; Xun, Yu; Rong, Shunxing; Yan, Lijuan; SoRelle, Jeffrey A.; Li, Xiaohong; Tang, Miao; Keller, Katie; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (July 16, 2022). "Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity". Nature Communications. 13 (1): 4136. Bibcode:2022NatCo..13.4136Z. doi:10.1038/s41467-022-31812-4. ISSN 2041-1723. PMC 9288484. PMID 35842425.
Smyth, Ian; Du, Xin; Taylor, Martin S.; Justice, Monica J.; Beutler, Bruce; Jackson, Ian J. (September 14, 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13560–13565. Bibcode:2004PNAS..10113560S. doi:10.1073/pnas.0402760101. ISSN 0027-8424. PMC 518794. PMID 15345741.
Israel, Laura; Wang, Ying; Bulek, Katarzyna; Della Mina, Erika; Zhang, Zhao; Pedergnana, Vincent; Chrabieh, Maya; Lemmens, Nicole A.; Sancho-Shimizu, Vanessa; Descatoire, Marc; Lasseau, Théo; Israelsson, Elisabeth; Lorenzo, Lazaro; Yun, Ling; Belkadi, Aziz (February 23, 2017). "Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity". Cell. 168 (5): 789–800.e10. doi:10.1016/j.cell.2017.01.039. ISSN 1097-4172. PMC 5328639. PMID 28235196.
El Hayek, Lauretta; Tuncay, Islam Oguz; Nijem, Nadine; Russell, Jamie; Ludwig, Sara; Kaur, Kiran; Li, Xiaohong; Anderton, Priscilla; Tang, Miao; Gerard, Amanda; Heinze, Anja; Zacher, Pia; Alsaif, Hessa S.; Rad, Aboulfazl; Hassanpour, Kazem (December 22, 2020). "KDM5A mutations identified in autism spectrum disorder using forward genetics". eLife. 9: e56883. doi:10.7554/eLife.56883. ISSN 2050-084X. PMC 7755391. PMID 33350388.
Rios, Jonathan J.; Denton, Kristin; Yu, Hao; Manickam, Kandamurugu; Garner, Shannon; Russell, Jamie; Ludwig, Sara; Rosenfeld, Jill A.; Liu, Pengfei; Munch, Jake; Sucato, Daniel J.; Beutler, Bruce; Wise, Carol A. (June 1, 2021). "Saturation mutagenesis defines novel mouse models of severe spine deformity". Disease Models & Mechanisms. 14 (6): dmm048901. doi:10.1242/dmm.048901. ISSN 1754-8411. PMC 8246263. PMID 34142127.
Rios, Jonathan J.; Denton, Kristin; Russell, Jamie; Kozlitina, Julia; Ferreira, Carlos R.; Lewanda, Amy F.; Mayfield, Joshua E.; Moresco, Eva; Ludwig, Sara; Tang, Miao; Li, Xiaohong; Lyon, Stephen; Khanshour, Anas; Paria, Nandina; Khalid, Aysha (August 2021). "Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice". Journal of Bone and Mineral Research. 36 (8): 1548–1565. doi:10.1002/jbmr.4323. ISSN 1523-4681. PMC 8862308. PMID 33905568.
Andrews, T. D.; Whittle, B.; Field, M. A.; Balakishnan, B.; Zhang, Y.; Shao, Y.; Cho, V.; Kirk, M.; Singh, M.; Xia, Y.; Hager, J.; Winslade, S.; Sjollema, G.; Beutler, B.; Enders, A. (May 2012). "Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models". Open Biology. 2 (5): 120061. doi:10.1098/rsob.120061. ISSN 2046-2441. PMC 3376740. PMID 22724066.
Bull, Katherine R.; Rimmer, Andrew J.; Siggs, Owen M.; Miosge, Lisa A.; Roots, Carla M.; Enders, Anselm; Bertram, Edward M.; Crockford, Tanya L.; Whittle, Belinda; Potter, Paul K.; Simon, Michelle M.; Mallon, Ann-Marie; Brown, Steve D. M.; Beutler, Bruce; Goodnow, Christopher C. (2013). "Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations". PLOS Genetics. 9 (1): e1003219. doi:10.1371/journal.pgen.1003219. ISSN 1553-7404. PMC 3561070. PMID 23382690.
Xia, Yu; Won, Sungyong; Du, Xin; Lin, Pei; Ross, Charles; La Vine, Diantha; Wiltshire, Sean; Leiva, Gabriel; Vidal, Silvia M.; Whittle, Belinda; Goodnow, Christopher C.; Koziol, James; Moresco, Eva Marie Y.; Beutler, Bruce (December 2010). "Bulk segregation mapping of mutations in closely related strains of mice". Genetics. 186 (4): 1139–1146. doi:10.1534/genetics.110.121160. ISSN 1943-2631. PMC 2998299. PMID 20923982.
Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Lyon, Stephen; Pratt, David; Hildebrand, Sara; Choi, Jin Huk; Zhang, Zhao; Zeng, Ming; Wang, Kuan-wen; Turer, Emre; Chen, Zhe; Zhang, Duanwu; Yue, Tao; Wang, Ying (February 3, 2015). "Real-time resolution of point mutations that cause phenovariance in mice". Proceedings of the National Academy of Sciences of the United States of America. 112 (5): E440–449. Bibcode:2015PNAS..112E.440W. doi:10.1073/pnas.1423216112. ISSN 1091-6490. PMC 4321302. PMID 25605905.
Wang, Tao; Bu, Chun Hui; Hildebrand, Sara; Jia, Gaoxiang; Siggs, Owen M.; Lyon, Stephen; Pratt, David; Scott, Lindsay; Russell, Jamie; Ludwig, Sara; Murray, Anne R.; Moresco, Eva Marie Y.; Beutler, Bruce (January 30, 2018). "Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database". Nature Communications. 9 (1): 441. Bibcode:2018NatCo...9..441W. doi:10.1038/s41467-017-02806-4. ISSN 2041-1723. PMC 5789985. PMID 29382827.
Xu, Darui; Lyon, Stephen; Bu, Chun Hui; Hildebrand, Sara; Choi, Jin Huk; Zhong, Xue; Liu, Aijie; Turer, Emre E.; Zhang, Zhao; Russell, Jamie; Ludwig, Sara; Mahrt, Elena; Nair-Gill, Evan; Shi, Hexin; Wang, Ying (July 13, 2021). "Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning". Proceedings of the National Academy of Sciences of the United States of America. 118 (28): e2106786118. Bibcode:2021PNAS..11806786X. doi:10.1073/pnas.2106786118. ISSN 1091-6490. PMC 8285956. PMID 34260399.
Chen, Bo; Aredo, Bogale; Ding, Yi; Zhong, Xin; Zhu, Yuanfei; Zhao, Cynthia X.; Kumar, Ashwani; Xing, Chao; Gautron, Laurent; Lyon, Stephen; Russell, Jamie; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Ludwig, Sara (June 9, 2020). "Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 12931–12942. Bibcode:2020PNAS..11712931C. doi:10.1073/pnas.1921224117. ISSN 1091-6490. PMC 7293615. PMID 32457148.
Wang, Yibing; Cao, Liqin; Lee, Chia-Ying; Matsuo, Tomohiko; Wu, Kejia; Asher, Greg; Tang, Lijun; Saitoh, Tsuyoshi; Russell, Jamie; Klewe-Nebenius, Daniela; Wang, Li; Soya, Shingo; Hasegawa, Emi; Chérasse, Yoan; Zhou, Jiamin (May 23, 2018). "Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors". Nature Communications. 9 (1): 2041. Bibcode:2018NatCo...9.2041W. doi:10.1038/s41467-018-04324-3. ISSN 2041-1723. PMC 5966455. PMID 29795268.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Mifune, Yuto; Su, Lijing; Shi, Hexin; Moresco, Eva Marie Y.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (October 31, 2018). "Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists". Journal of the American Chemical Society. 140 (43): 14440–14454. doi:10.1021/jacs.8b09223. ISSN 1520-5126. PMC 6209530. PMID 30272974.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Su, Lijing; Surakattula, Murali M. R. P.; Berger, Michael; Huang, Hua; Beutler, Elliot K.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (May 26, 2016). "Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists". Journal of Medicinal Chemistry. 59 (10): 4812–4830. doi:10.1021/acs.jmedchem.6b00177. ISSN 1520-4804. PMC 4882283. PMID 27050713.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Mifune, Yuto; Shi, Hexin; Wang, Kuan-Wen; Zhan, Xiaoming; Liu, Aijie; Wang, Jianhui; Li, Xiaohong; Tang, Miao; Ludwig, Sara; Hildebrand, Sara; Zhou, Kejin (September 11, 2018). "Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice". Proceedings of the National Academy of Sciences of the United States of America. 115 (37): E8698 – E8706. Bibcode:2018PNAS..115E8698W. doi:10.1073/pnas.1809232115. ISSN 1091-6490. PMC 6140543. PMID 30150374.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Whitby, Landon R.; Surakattula, Murali M. R. P.; Huang, Hua; Shi, Hexin; Choi, Jin Huk; Wang, Kuan-wen; Moresco, Eva Marie Y.; Berger, Michael; Zhan, Xiaoming; Zhang, Hong; Boger, Dale L. (February 16, 2016). "TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS". Proceedings of the National Academy of Sciences of the United States of America. 113 (7): E884–893. Bibcode:2016PNAS..113E.884W. doi:10.1073/pnas.1525639113. ISSN 1091-6490. PMC 4763747. PMID 26831104.
Su, Lijing; Athamna, Muhammad; Wang, Ying; Wang, Junmei; Freudenberg, Marina; Yue, Tao; Wang, Jianhui; Moresco, Eva Marie Y.; He, Haoming; Zor, Tsaffrir; Beutler, Bruce (July 27, 2021). "Sulfatides are endogenous ligands for the TLR4-MD-2 complex". Proceedings of the National Academy of Sciences of the United States of America. 118 (30): e2105316118. Bibcode:2021PNAS..11805316S. doi:10.1073/pnas.2105316118. ISSN 1091-6490. PMC 8325290. PMID 34290146.
Su, Lijing; Wang, Ying; Wang, Junmei; Mifune, Yuto; Morin, Matthew D.; Jones, Brian T.; Moresco, Eva Marie Y.; Boger, Dale L.; Beutler, Bruce; Zhang, Hong (March 28, 2019). "Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim". Journal of Medicinal Chemistry. 62 (6): 2938–2949. doi:10.1021/acs.jmedchem.8b01583. ISSN 1520-4804. PMC 6537610. PMID 30829478.
Yang, Ming-Hsiu; Russell, Jamie L.; Mifune, Yuto; Wang, Ying; Shi, Hexin; Moresco, Eva Marie Y.; Siegwart, Daniel J.; Beutler, Bruce; Boger, Dale L. (July 14, 2022). "Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response". Journal of Medicinal Chemistry. 65 (13): 9230–9252. doi:10.1021/acs.jmedchem.2c00419. ISSN 1520-4804. PMC 9283309. PMID 35767437.
Beutler, Bruce (January 1, 2009). "Ernest Beutler (1928–2008)". Haematologica. 94 (1): 154–156. doi:10.3324/haematol.13863. ISSN 1592-8721. PMC 2625414. PMID 19118377. S2CID 43531611.
Beutler, E.; Yeh, M.; Fairbanks, V. F. (January 15, 1962). "The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker". Proceedings of the National Academy of Sciences of the United States of America. 48 (1): 9–16. Bibcode:1962PNAS...48....9B. doi:10.1073/pnas.48.1.9. ISSN 0027-8424. PMC 285481. PMID 13868717.
Beutler, E.; Gelbart, T.; Han, J. H.; Koziol, J. A.; Beutler, B. (January 1989). "Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage". Proceedings of the National Academy of Sciences of the United States of America. 86 (1): 192–196. Bibcode:1989PNAS...86..192B. doi:10.1073/pnas.86.1.192. ISSN 0027-8424. PMC 286430. PMID 2463621.
Du, Xin; She, Ellen; Gelbart, Terri; Truksa, Jaroslav; Lee, Pauline; Xia, Yu; Khovananth, Kevin; Mudd, Suzanne; Mann, Navjiwan; Moresco, Eva Marie Y.; Beutler, Ernest; Beutler, Bruce (May 23, 2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. ISSN 1095-9203. PMC 2430097. PMID 18451267.

nobelprize.org

"Nobel Prize in Physiology or Medicine 2011" (Press release). Nobel Foundation. October 3, 2011.
"Bruce A. Beutler - Biographical - NobelPrize.org". Retrieved March 9, 2023.

nytimes.com

"HANS G. BEUTLER, 46, PHYSICIST, IS DEAD; Research Aide on the Chicago U. Faculty Was Spectroscopist". The New York Times. December 19, 1942. Retrieved March 9, 2023.

peoplenewspapers.com

"Lamplighter Has Ties to Nobel Prize Winner - People Newspapers". October 5, 2011. Retrieved November 30, 2023.

science.co.il

"Jewish Nobel Prize laureates - Physiology and medicine". www.science.co.il. Retrieved March 29, 2023.

semanticscholar.org

api.semanticscholar.org

Hemmi, Hiroaki; Kaisho, Tsuneyasu; Takeuchi, Osamu; Sato, Shintaro; Sanjo, Hideki; Hoshino, Katsuaki; Horiuchi, Takao; Tomizawa, Hideyuki; Takeda, Kiyoshi; Akira, Shizuo (January 22, 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nature Immunology. 3 (2): 196–200. doi:10.1038/ni758. ISSN 1529-2908. PMID 11812998. S2CID 1694900.
Hemmi, H.; Takeuchi, O.; Kawai, T.; Kaisho, T.; Sato, S.; Sanjo, H.; Matsumoto, M.; Hoshino, K.; Wagner, H.; Takeda, K.; Akira, S. (December 7, 2000). "A Toll-like receptor recognizes bacterial DNA". Nature. 408 (6813): 740–745. Bibcode:2000Natur.408..740H. doi:10.1038/35047123. ISSN 0028-0836. PMID 11130078. S2CID 4405163.
Takeuchi, Osamu; Sato, Shintaro; Horiuchi, Takao; Hoshino, Katsuaki; Takeda, Kiyoshi; Dong, Zhongyun; Modlin, Robert L.; Akira, Shizuo (July 1, 2002). "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". Journal of Immunology. 169 (1): 10–14. doi:10.4049/jimmunol.169.1.10. ISSN 0022-1767. PMID 12077222. S2CID 22686400.
Beutler, E.; West, C.; Beutler, B. (October 1974). "Electrophoretic polymorphism of glutathione peroxidase". Annals of Human Genetics. 38 (2): 163–169. doi:10.1111/j.1469-1809.1974.tb01947.x. ISSN 0003-4800. PMID 4467780. S2CID 32294741.
Beutler, E.; Beutler, B.; Matsumoto, J. (July 15, 1975). "Glutathione peroxidase activity of inorganic selenium and seleno-DL-cysteine". Experientia. 31 (7): 769–770. doi:10.1007/BF01938453. ISSN 0014-4754. PMID 1140308. S2CID 26234261.
Ohno, S. (January 1977). "The original function of MHC antigens as the general plasma membrane anchorage site of organogenesis-directing proteins". Immunological Reviews. 33: 59–69. doi:10.1111/j.1600-065X.1977.tb00362.x. ISSN 0105-2896. PMID 66186. S2CID 45992817.
Beutler, B.; Nagai, Y.; Ohno, S.; Klein, G.; Shapiro, I. M. (March 1978). "The HLA-dependent expression of testis- organizing H-Y antigen by human male cells". Cell. 13 (3): 509–513. doi:10.1016/0092-8674(78)90324-0. ISSN 0092-8674. PMID 77737. S2CID 33827976.
Beutler, B.; Greenwald, D.; Hulmes, J. D.; Chang, M.; Pan, Y. C.; Mathison, J.; Ulevitch, R.; Cerami, A. (August 1, 1985). "Identity of tumour necrosis factor and the macrophage-secreted factor cachectin". Nature. 316 (6028): 552–554. Bibcode:1985Natur.316..552B. doi:10.1038/316552a0. ISSN 0028-0836. PMID 2993897. S2CID 4339006.
Loetscher, H.; Pan, Y. C.; Lahm, H. W.; Gentz, R.; Brockhaus, M.; Tabuchi, H.; Lesslauer, W. (April 20, 1990). "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor". Cell. 61 (2): 351–359. doi:10.1016/0092-8674(90)90815-v. ISSN 0092-8674. PMID 2158862. S2CID 42245440.
Schall, T. J.; Lewis, M.; Koller, K. J.; Lee, A.; Rice, G. C.; Wong, G. H.; Gatanaga, T.; Granger, G. A.; Lentz, R.; Raab, H. (April 20, 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell. 61 (2): 361–370. doi:10.1016/0092-8674(90)90816-w. ISSN 0092-8674. PMID 2158863. S2CID 36187863.
Coutinho, A.; Meo, T. (December 1978). "Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice". Immunogenetics. 7 (1): 17–24. doi:10.1007/BF01843983. ISSN 0093-7711. PMID 21302052. S2CID 29425605.
Sultzer, B. M. (September 21, 1968). "Genetic control of leucocyte responses to endotoxin". Nature. 219 (5160): 1253–1254. Bibcode:1968Natur.219.1253S. doi:10.1038/2191253a0. ISSN 0028-0836. PMID 4877918. S2CID 41633552.
Beutler, Bruce (January 2002). "Toll-like receptors: how they work and what they do". Current Opinion in Hematology. 9 (1): 2–10. doi:10.1097/00062752-200201000-00002. ISSN 1065-6251. PMID 11753071. S2CID 36843541.
Park, Beom Seok; Song, Dong Hyun; Kim, Ho Min; Choi, Byong-Seok; Lee, Hayyoung; Lee, Jie-Oh (April 30, 2009). "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex". Nature. 458 (7242): 1191–1195. Bibcode:2009Natur.458.1191P. doi:10.1038/nature07830. ISSN 1476-4687. PMID 19252480. S2CID 4396446.
Lemaitre, B.; Nicolas, E.; Michaut, L.; Reichhart, J. M.; Hoffmann, J. A. (September 20, 1996). "The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults". Cell. 86 (6): 973–983. doi:10.1016/s0092-8674(00)80172-5. ISSN 0092-8674. PMID 8808632. S2CID 10736743.
Medzhitov, R.; Preston-Hurlburt, P.; Janeway, C. A. (July 24, 1997). "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity". Nature. 388 (6640): 394–397. doi:10.1038/41131. ISSN 0028-0836. PMID 9237759. S2CID 4311321.
Yang, R. B.; Mark, M. R.; Gray, A.; Huang, A.; Xie, M. H.; Zhang, M.; Goddard, A.; Wood, W. I.; Gurney, A. L.; Godowski, P. J. (September 17, 1998). "Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling". Nature. 395 (6699): 284–288. Bibcode:1998Natur.395..284Y. doi:10.1038/26239. ISSN 0028-0836. PMID 9751057. S2CID 4422827.
Leadbetter, Elizabeth A.; Rifkin, Ian R.; Hohlbaum, Andreas M.; Beaudette, Britte C.; Shlomchik, Mark J.; Marshak-Rothstein, Ann (April 11, 2002). "Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors". Nature. 416 (6881): 603–607. doi:10.1038/416603a. ISSN 0028-0836. PMID 11948342. S2CID 4370544.
Beutler, Bruce; Du, Xin; Xia, Yu (July 2007). "Precis on forward genetics in mice". Nature Immunology. 8 (7): 659–664. doi:10.1038/ni0707-659. ISSN 1529-2908. PMID 17579639. S2CID 28309476.
Hoebe, K.; Du, X.; Georgel, P.; Janssen, E.; Tabeta, K.; Kim, S. O.; Goode, J.; Lin, P.; Mann, N.; Mudd, S.; Crozat, K.; Sovath, S.; Han, J.; Beutler, B. (August 14, 2003). "Identification of Lps2 as a key transducer of MyD88-independent TIR signalling". Nature. 424 (6950): 743–748. Bibcode:2003Natur.424..743H. doi:10.1038/nature01889. ISSN 1476-4687. PMID 12872135. S2CID 15608748.
Hoebe, Kasper; Georgel, Philippe; Rutschmann, Sophie; Du, Xin; Mudd, Suzanne; Crozat, Karine; Sovath, Sosathya; Shamel, Louis; Hartung, Thomas; Zähringer, Ulrich; Beutler, Bruce (February 3, 2005). "CD36 is a sensor of diacylglycerides". Nature. 433 (7025): 523–527. Bibcode:2005Natur.433..523H. doi:10.1038/nature03253. ISSN 1476-4687. PMID 15690042. S2CID 4406318.
Tabeta, Koichi; Hoebe, Kasper; Janssen, Edith M.; Du, Xin; Georgel, Philippe; Crozat, Karine; Mudd, Suzanne; Mann, Navjiwan; Sovath, Sosathya; Goode, Jason; Shamel, Louis; Herskovits, Anat A.; Portnoy, Daniel A.; Cooke, Michael; Tarantino, Lisa M. (January 15, 2006). "The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9". Nature Immunology. 7 (2): 156–164. doi:10.1038/ni1297. ISSN 1529-2908. PMID 16415873. S2CID 33401155.
Kim, You-Me; Brinkmann, Melanie M.; Paquet, Marie-Eve; Ploegh, Hidde L. (March 13, 2008). "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes". Nature. 452 (7184): 234–238. Bibcode:2008Natur.452..234K. doi:10.1038/nature06726. ISSN 1476-4687. PMID 18305481. S2CID 4397023.
Casrouge, Armanda; Zhang, Shen-Ying; Eidenschenk, Céline; Jouanguy, Emmanuelle; Puel, Anne; Yang, Kun; Alcais, Alexandre; Picard, Capucine; Mahfoufi, Nora; Nicolas, Nathalie; Lorenzo, Lazaro; Plancoulaine, Sabine; Sénéchal, Brigitte; Geissmann, Frédéric; Tabeta, Koichi (October 13, 2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797): 308–312. Bibcode:2006Sci...314..308C. doi:10.1126/science.1128346. ISSN 1095-9203. PMID 16973841. S2CID 12501759.
Lazar, Daniel C.; Wang, Wesley W.; Chiu, Tzu-Yuan; Li, Weichao; Jadhav, Appaso M.; Wozniak, Jacob M.; Gazaniga, Nathalia; Theofilopoulos, Argyrios N.; Teijaro, John R.; Parker, Christopher G. (October 7, 2022), Chemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity, doi:10.1101/2022.10.07.511216, S2CID 252820006
Beutler, Bruce; Eidenschenk, Celine; Crozat, Karine; Imler, Jean-Luc; Takeuchi, Osamu; Hoffmann, Jules A.; Akira, Shizuo (October 2007). "Genetic analysis of resistance to viral infection". Nature Reviews. Immunology. 7 (10): 753–766. doi:10.1038/nri2174. ISSN 1474-1741. PMID 17893693. S2CID 37705652.
Croker, B.; Crozat, K.; Berger, M.; Xia, Y.; Sovath, S.; Schaffer, L.; Eleftherianos, I.; Imler, J. L.; Beutler, B. (2007). "ATP-sensitive potassium channels mediate survival during infection in mammals and insects". Nature Genetics. 39 (12): 1453–1460. doi:10.1038/ng.2007.25. PMID 18026101. S2CID 41183715.
Al-Fadhli, Fatima M.; Afqi, Manal; Sairafi, Mona Hamza; Almuntashri, Makki; Alharby, Essa; Alharbi, Ghadeer; Abdud Samad, Firoz; Hashmi, Jamil Amjad; Zaytuni, Dimah; Bahashwan, Ahmed A.; Choi, Jin Huk; Peake, Roy W. A.; Beutler, Bruce; Almontashiri, Naif A. M. (May 2021). "Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes". Clinical Genetics. 99 (5): 694–703. doi:10.1111/cge.13930. ISSN 1399-0004. PMID 33495992. S2CID 231710148.
Melis, Maria Antonietta; Cau, Milena; Congiu, Rita; Sole, Gabriella; Barella, Susanna; Cao, Antonio; Westerman, Mark; Cazzola, Mario; Galanello, Renzo (October 2008). "A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron". Haematologica. 93 (10): 1473–1479. doi:10.3324/haematol.13342. ISSN 1592-8721. PMID 18603562. S2CID 23364362.
Beutler, Bruce (January 1, 2009). "Ernest Beutler (1928–2008)". Haematologica. 94 (1): 154–156. doi:10.3324/haematol.13863. ISSN 1592-8721. PMC 2625414. PMID 19118377. S2CID 43531611.
Truksa, Jaroslav; Gelbart, Terri; Peng, Hongfan; Beutler, Ernest; Beutler, Bruce; Lee, Pauline (November 2009). "Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6". British Journal of Haematology. 147 (4): 571–581. doi:10.1111/j.1365-2141.2009.07873.x. ISSN 1365-2141. PMID 19751239. S2CID 205266224.
Hildebrandt, Sabine; Kammertöns, Thomas; Lechner, Christian; Schmitt, Philipp; Schumann, Ralf R. (2019). "Dr. Käthe Beutler, 1896–1999". Medizinhistorisches Journal. 54 (4): 294–346. doi:10.25162/mhj-2019-0009. ISSN 0025-8431. S2CID 213008951.

shawprize.org

"2011 Life Science & Medicine". The Shaw Prize. Retrieved November 30, 2023.
"Bruce A Beutler". The Shaw Prize. Retrieved November 30, 2023.

the-asci.org

beta.the-asci.org

"Bruce Beutler, MD". The American Society for Clinical Investigation. Retrieved October 18, 2023.

uchicago.edu

news.uchicago.edu

Easton, John (October 10, 2011). "Alumnus Bruce Beutler, MD'81, to receive 2011 Nobel Prize in Medicine". uchicago news. Retrieved March 9, 2023.

universitetsavisa.no

Kristoffer Furberg (March 20, 2015). "169 nye NTNU-doktorer hedret". Universitetsavisa (in Norwegian). Archived from the original on July 14, 2018. Retrieved March 25, 2015.

utsouthwestern.edu

"Center for the Genetics of Host Defense - UT Southwestern, Dallas, TX". Retrieved March 9, 2023.

web.archive.org

Kristoffer Furberg (March 20, 2015). "169 nye NTNU-doktorer hedret". Universitetsavisa (in Norwegian). Archived from the original on July 14, 2018. Retrieved March 25, 2015.

worldcat.org

search.worldcat.org

Poltorak, A.; He, X.; Smirnova, I.; Liu, M. Y.; Van Huffel, C.; Du, X.; Birdwell, D.; Alejos, E.; Silva, M.; Galanos, C.; Freudenberg, M.; Ricciardi-Castagnoli, P.; Layton, B.; Beutler, B. (December 11, 1998). "Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene". Science. 282 (5396): 2085–2088. doi:10.1126/science.282.5396.2085. ISSN 0036-8075. PMID 9851930.
Hemmi, Hiroaki; Kaisho, Tsuneyasu; Takeuchi, Osamu; Sato, Shintaro; Sanjo, Hideki; Hoshino, Katsuaki; Horiuchi, Takao; Tomizawa, Hideyuki; Takeda, Kiyoshi; Akira, Shizuo (January 22, 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nature Immunology. 3 (2): 196–200. doi:10.1038/ni758. ISSN 1529-2908. PMID 11812998. S2CID 1694900.
Hemmi, H.; Takeuchi, O.; Kawai, T.; Kaisho, T.; Sato, S.; Sanjo, H.; Matsumoto, M.; Hoshino, K.; Wagner, H.; Takeda, K.; Akira, S. (December 7, 2000). "A Toll-like receptor recognizes bacterial DNA". Nature. 408 (6813): 740–745. Bibcode:2000Natur.408..740H. doi:10.1038/35047123. ISSN 0028-0836. PMID 11130078. S2CID 4405163.
Takeuchi, O.; Hoshino, K.; Kawai, T.; Sanjo, H.; Takada, H.; Ogawa, T.; Takeda, K.; Akira, S. (October 1, 1999). "Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components". Immunity. 11 (4): 443–451. doi:10.1016/s1074-7613(00)80119-3. ISSN 1074-7613. PMID 10549626.
Takeuchi, O.; Kawai, T.; Mühlradt, P. F.; Morr, M.; Radolf, J. D.; Zychlinsky, A.; Takeda, K.; Akira, S. (July 1, 2001). "Discrimination of bacterial lipoproteins by Toll-like receptor 6". International Immunology. 13 (7): 933–940. doi:10.1093/intimm/13.7.933. ISSN 0953-8178. PMID 11431423.
Takeuchi, Osamu; Sato, Shintaro; Horiuchi, Takao; Hoshino, Katsuaki; Takeda, Kiyoshi; Dong, Zhongyun; Modlin, Robert L.; Akira, Shizuo (July 1, 2002). "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". Journal of Immunology. 169 (1): 10–14. doi:10.4049/jimmunol.169.1.10. ISSN 0022-1767. PMID 12077222. S2CID 22686400.
Beutler, E.; West, C.; Beutler, B. (October 1974). "Electrophoretic polymorphism of glutathione peroxidase". Annals of Human Genetics. 38 (2): 163–169. doi:10.1111/j.1469-1809.1974.tb01947.x. ISSN 0003-4800. PMID 4467780. S2CID 32294741.
Beutler, E.; Beutler, B.; Matsumoto, J. (July 15, 1975). "Glutathione peroxidase activity of inorganic selenium and seleno-DL-cysteine". Experientia. 31 (7): 769–770. doi:10.1007/BF01938453. ISSN 0014-4754. PMID 1140308. S2CID 26234261.
Ohno, S. (January 1977). "The original function of MHC antigens as the general plasma membrane anchorage site of organogenesis-directing proteins". Immunological Reviews. 33: 59–69. doi:10.1111/j.1600-065X.1977.tb00362.x. ISSN 0105-2896. PMID 66186. S2CID 45992817.
Beutler, B.; Nagai, Y.; Ohno, S.; Klein, G.; Shapiro, I. M. (March 1978). "The HLA-dependent expression of testis- organizing H-Y antigen by human male cells". Cell. 13 (3): 509–513. doi:10.1016/0092-8674(78)90324-0. ISSN 0092-8674. PMID 77737. S2CID 33827976.
Beutler, B.; Greenwald, D.; Hulmes, J. D.; Chang, M.; Pan, Y. C.; Mathison, J.; Ulevitch, R.; Cerami, A. (August 1, 1985). "Identity of tumour necrosis factor and the macrophage-secreted factor cachectin". Nature. 316 (6028): 552–554. Bibcode:1985Natur.316..552B. doi:10.1038/316552a0. ISSN 0028-0836. PMID 2993897. S2CID 4339006.
Beutler, B.; Mahoney, J.; Le Trang, N.; Pekala, P.; Cerami, A. (May 1, 1985). "Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells". The Journal of Experimental Medicine. 161 (5): 984–995. doi:10.1084/jem.161.5.984. ISSN 0022-1007. PMC 2187615. PMID 3872925.
Aggarwal, B. B.; Kohr, W. J.; Hass, P. E.; Moffat, B.; Spencer, S. A.; Henzel, W. J.; Bringman, T. S.; Nedwin, G. E.; Goeddel, D. V.; Harkins, R. N. (February 25, 1985). "Human tumor necrosis factor. Production, purification, and characterization". The Journal of Biological Chemistry. 260 (4): 2345–2354. doi:10.1016/S0021-9258(18)89560-6. ISSN 0021-9258. PMID 3871770.
Beutler, B.; Milsark, I. W.; Cerami, A. C. (August 30, 1985). "Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin". Science. 229 (4716): 869–871. Bibcode:1985Sci...229..869B. doi:10.1126/science.3895437. ISSN 0036-8075. PMID 3895437.
Dayer, J. M.; Beutler, B.; Cerami, A. (December 1, 1985). "Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts". The Journal of Experimental Medicine. 162 (6): 2163–2168. doi:10.1084/jem.162.6.2163. ISSN 0022-1007. PMC 2187983. PMID 2999289.
Feldmann, M.; Brennan, F. M.; Maini, R. N. (1996). "Role of cytokines in rheumatoid arthritis". Annual Review of Immunology. 14: 397–440. doi:10.1146/annurev.immunol.14.1.397. ISSN 0732-0582. PMID 8717520.
Engelmann, H.; Novick, D.; Wallach, D. (January 25, 1990). "Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors". The Journal of Biological Chemistry. 265 (3): 1531–1536. doi:10.1016/S0021-9258(19)40049-5. ISSN 0021-9258. PMID 2153136.
Loetscher, H.; Pan, Y. C.; Lahm, H. W.; Gentz, R.; Brockhaus, M.; Tabuchi, H.; Lesslauer, W. (April 20, 1990). "Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor". Cell. 61 (2): 351–359. doi:10.1016/0092-8674(90)90815-v. ISSN 0092-8674. PMID 2158862. S2CID 42245440.
Nophar, Y.; Kemper, O.; Brakebusch, C.; Englemann, H.; Zwang, R.; Aderka, D.; Holtmann, H.; Wallach, D. (October 1, 1990). "Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor". The EMBO Journal. 9 (10): 3269–3278. doi:10.1002/j.1460-2075.1990.tb07526.x. ISSN 0261-4189. PMC 552060. PMID 1698610.
Schall, T. J.; Lewis, M.; Koller, K. J.; Lee, A.; Rice, G. C.; Wong, G. H.; Gatanaga, T.; Granger, G. A.; Lentz, R.; Raab, H. (April 20, 1990). "Molecular cloning and expression of a receptor for human tumor necrosis factor". Cell. 61 (2): 361–370. doi:10.1016/0092-8674(90)90816-w. ISSN 0092-8674. PMID 2158863. S2CID 36187863.
Smith, C. A.; Davis, T.; Anderson, D.; Solam, L.; Beckmann, M. P.; Jerzy, R.; Dower, S. K.; Cosman, D.; Goodwin, R. G. (May 25, 1990). "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins". Science. 248 (4958): 1019–1023. Bibcode:1990Sci...248.1019S. doi:10.1126/science.2160731. ISSN 0036-8075. PMID 2160731.
Poltorak, A.; Peppel, K.; Beutler, B. (February 28, 1994). "Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations". Journal of Immunological Methods. 169 (1): 93–99. doi:10.1016/0022-1759(94)90128-7. ISSN 0022-1759. PMID 8133076.
Peppel, K.; Crawford, D.; Beutler, B. (December 1, 1991). "A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity". The Journal of Experimental Medicine. 174 (6): 1483–1489. doi:10.1084/jem.174.6.1483. ISSN 0022-1007. PMC 2119031. PMID 1660525.
Beutler, B.; Poltorak, A. (July 2001). "Sepsis and evolution of the innate immune response". Critical Care Medicine. 29 (7 Suppl): S2–6, discussion S6–7. doi:10.1097/00003246-200107001-00002. ISSN 0090-3493. PMID 11445725.
Johnson, A. G.; Gaines, S.; Landy, M. (February 1, 1956). "Studies on the O antigen of Salmonella typhosa. V. Enhancement of antibody response to protein antigens by the purified lipopolysaccharide". The Journal of Experimental Medicine. 103 (2): 225–246. doi:10.1084/jem.103.2.225. ISSN 0022-1007. PMC 2136584. PMID 13286429.
Coutinho, A.; Meo, T. (December 1978). "Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice". Immunogenetics. 7 (1): 17–24. doi:10.1007/BF01843983. ISSN 0093-7711. PMID 21302052. S2CID 29425605.
Watson, J.; Riblet, R. (November 1, 1974). "Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic respones [sic] to lipopolysaccharides". The Journal of Experimental Medicine. 140 (5): 1147–1161. doi:10.1084/jem.140.5.1147. ISSN 0022-1007. PMC 2139714. PMID 4138849.
Sultzer, B. M. (September 21, 1968). "Genetic control of leucocyte responses to endotoxin". Nature. 219 (5160): 1253–1254. Bibcode:1968Natur.219.1253S. doi:10.1038/2191253a0. ISSN 0028-0836. PMID 4877918. S2CID 41633552.
Beutler, Bruce (January 2002). "Toll-like receptors: how they work and what they do". Current Opinion in Hematology. 9 (1): 2–10. doi:10.1097/00062752-200201000-00002. ISSN 1065-6251. PMID 11753071. S2CID 36843541.
Du, X.; Poltorak, A.; Silva, M.; Beutler, B. (1999). "Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor". Blood Cells, Molecules & Diseases. 25 (5–6): 328–338. doi:10.1006/bcmd.1999.0262. ISSN 1079-9796. PMID 10660480.
Poltorak, A.; Ricciardi-Castagnoli, P.; Citterio, S.; Beutler, B. (February 29, 2000). "Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2163–2167. Bibcode:2000PNAS...97.2163P. doi:10.1073/pnas.040565397. ISSN 0027-8424. PMC 15771. PMID 10681462.
Shimazu, R.; Akashi, S.; Ogata, H.; Nagai, Y.; Fukudome, K.; Miyake, K.; Kimoto, M. (June 7, 1999). "MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4". The Journal of Experimental Medicine. 189 (11): 1777–1782. doi:10.1084/jem.189.11.1777. ISSN 0022-1007. PMC 2193086. PMID 10359581.
Park, Beom Seok; Song, Dong Hyun; Kim, Ho Min; Choi, Byong-Seok; Lee, Hayyoung; Lee, Jie-Oh (April 30, 2009). "The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex". Nature. 458 (7242): 1191–1195. Bibcode:2009Natur.458.1191P. doi:10.1038/nature07830. ISSN 1476-4687. PMID 19252480. S2CID 4396446.
Lemaitre, B.; Nicolas, E.; Michaut, L.; Reichhart, J. M.; Hoffmann, J. A. (September 20, 1996). "The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults". Cell. 86 (6): 973–983. doi:10.1016/s0092-8674(00)80172-5. ISSN 0092-8674. PMID 8808632. S2CID 10736743.
Medzhitov, R.; Preston-Hurlburt, P.; Janeway, C. A. (July 24, 1997). "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity". Nature. 388 (6640): 394–397. doi:10.1038/41131. ISSN 0028-0836. PMID 9237759. S2CID 4311321.
Kirschning, C. J.; Wesche, H.; Merrill Ayres, T.; Rothe, M. (December 7, 1998). "Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide". The Journal of Experimental Medicine. 188 (11): 2091–2097. doi:10.1084/jem.188.11.2091. ISSN 0022-1007. PMC 2212382. PMID 9841923.
Yang, R. B.; Mark, M. R.; Gray, A.; Huang, A.; Xie, M. H.; Zhang, M.; Goddard, A.; Wood, W. I.; Gurney, A. L.; Godowski, P. J. (September 17, 1998). "Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling". Nature. 395 (6699): 284–288. Bibcode:1998Natur.395..284Y. doi:10.1038/26239. ISSN 0028-0836. PMID 9751057. S2CID 4422827.
Beutler, B.; Poltorak, A. (June 2000). "Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response". European Cytokine Network. 11 (2): 143–152. ISSN 1148-5493. PMID 10903793.
Christensen, Sean R.; Shupe, Jonathan; Nickerson, Kevin; Kashgarian, Michael; Flavell, Richard A.; Shlomchik, Mark J. (September 2006). "Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus". Immunity. 25 (3): 417–428. doi:10.1016/j.immuni.2006.07.013. ISSN 1074-7613. PMID 16973389.
Brown, Grant J.; Cañete, Pablo F.; Wang, Hao; Medhavy, Arti; Bones, Josiah; Roco, Jonathan A.; He, Yuke; Qin, Yuting; Cappello, Jean; Ellyard, Julia I.; Bassett, Katharine; Shen, Qian; Burgio, Gaetan; Zhang, Yaoyuan; Turnbull, Cynthia (May 2022). "TLR7 gain-of-function genetic variation causes human lupus". Nature. 605 (7909): 349–356. Bibcode:2022Natur.605..349B. doi:10.1038/s41586-022-04642-z. ISSN 1476-4687. PMC 9095492. PMID 35477763.
Leibler, Claire; John, Shinu; Elsner, Rebecca A.; Thomas, Kayla B.; Smita, Shuchi; Joachim, Stephen; Levack, Russell C.; Callahan, Derrick J.; Gordon, Rachael A.; Bastacky, Sheldon; Fukui, Ryutaro; Miyake, Kensuke; Gingras, Sebastien; Nickerson, Kevin M.; Shlomchik, Mark J. (October 2022). "Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus". Nature Immunology. 23 (10): 1457–1469. doi:10.1038/s41590-022-01310-2. ISSN 1529-2916. PMC 9561083. PMID 36151396.
Baccala, Roberto; Gonzalez-Quintial, Rosana; Blasius, Amanda L.; Rimann, Ivo; Ozato, Keiko; Kono, Dwight H.; Beutler, Bruce; Theofilopoulos, Argyrios N. (February 19, 2013). "Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus". Proceedings of the National Academy of Sciences of the United States of America. 110 (8): 2940–2945. Bibcode:2013PNAS..110.2940B. doi:10.1073/pnas.1222798110. ISSN 1091-6490. PMC 3581947. PMID 23382217.
Kono, Dwight H.; Haraldsson, M. Katarina; Lawson, Brian R.; Pollard, K. Michael; Koh, Yi Ting; Du, Xin; Arnold, Carrie N.; Baccala, Roberto; Silverman, Gregg J.; Beutler, Bruce A.; Theofilopoulos, Argyrios N. (July 21, 2009). "Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus". Proceedings of the National Academy of Sciences of the United States of America. 106 (29): 12061–12066. Bibcode:2009PNAS..10612061K. doi:10.1073/pnas.0905441106. ISSN 1091-6490. PMC 2715524. PMID 19574451.
Lau, Christina M.; Broughton, Courtney; Tabor, Abigail S.; Akira, Shizuo; Flavell, Richard A.; Mamula, Mark J.; Christensen, Sean R.; Shlomchik, Mark J.; Viglianti, Gregory A.; Rifkin, Ian R.; Marshak-Rothstein, Ann (November 7, 2005). "RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement". The Journal of Experimental Medicine. 202 (9): 1171–1177. doi:10.1084/jem.20050630. ISSN 0022-1007. PMC 2213226. PMID 16260486.
Leadbetter, Elizabeth A.; Rifkin, Ian R.; Hohlbaum, Andreas M.; Beaudette, Britte C.; Shlomchik, Mark J.; Marshak-Rothstein, Ann (April 11, 2002). "Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors". Nature. 416 (6881): 603–607. doi:10.1038/416603a. ISSN 0028-0836. PMID 11948342. S2CID 4370544.
Viglianti, Gregory A.; Lau, Christina M.; Hanley, Timothy M.; Miko, Benjamin A.; Shlomchik, Mark J.; Marshak-Rothstein, Ann (December 2003). "Activation of autoreactive B cells by CpG dsDNA". Immunity. 19 (6): 837–847. doi:10.1016/s1074-7613(03)00323-6. ISSN 1074-7613. PMID 14670301.
Beutler, Bruce; Du, Xin; Xia, Yu (July 2007). "Precis on forward genetics in mice". Nature Immunology. 8 (7): 659–664. doi:10.1038/ni0707-659. ISSN 1529-2908. PMID 17579639. S2CID 28309476.
Hoebe, K.; Du, X.; Georgel, P.; Janssen, E.; Tabeta, K.; Kim, S. O.; Goode, J.; Lin, P.; Mann, N.; Mudd, S.; Crozat, K.; Sovath, S.; Han, J.; Beutler, B. (August 14, 2003). "Identification of Lps2 as a key transducer of MyD88-independent TIR signalling". Nature. 424 (6950): 743–748. Bibcode:2003Natur.424..743H. doi:10.1038/nature01889. ISSN 1476-4687. PMID 12872135. S2CID 15608748.
Hoebe, Kasper; Georgel, Philippe; Rutschmann, Sophie; Du, Xin; Mudd, Suzanne; Crozat, Karine; Sovath, Sosathya; Shamel, Louis; Hartung, Thomas; Zähringer, Ulrich; Beutler, Bruce (February 3, 2005). "CD36 is a sensor of diacylglycerides". Nature. 433 (7025): 523–527. Bibcode:2005Natur.433..523H. doi:10.1038/nature03253. ISSN 1476-4687. PMID 15690042. S2CID 4406318.
Tabeta, Koichi; Hoebe, Kasper; Janssen, Edith M.; Du, Xin; Georgel, Philippe; Crozat, Karine; Mudd, Suzanne; Mann, Navjiwan; Sovath, Sosathya; Goode, Jason; Shamel, Louis; Herskovits, Anat A.; Portnoy, Daniel A.; Cooke, Michael; Tarantino, Lisa M. (January 15, 2006). "The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9". Nature Immunology. 7 (2): 156–164. doi:10.1038/ni1297. ISSN 1529-2908. PMID 16415873. S2CID 33401155.
Croker, Ben A.; Lawson, Brian R.; Rutschmann, Sophie; Berger, Michael; Eidenschenk, Celine; Blasius, Amanda L.; Moresco, Eva Marie Y.; Sovath, Sosathya; Cengia, Louise; Shultz, Leonard D.; Theofilopoulos, Argyrios N.; Pettersson, Sven; Beutler, Bruce Alan (September 30, 2008). "Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger". Proceedings of the National Academy of Sciences of the United States of America. 105 (39): 15028–15033. Bibcode:2008PNAS..10515028C. doi:10.1073/pnas.0806619105. ISSN 1091-6490. PMC 2567487. PMID 18806225.
Shi, Hexin; Wang, Ying; Li, Xiaohong; Zhan, Xiaoming; Tang, Miao; Fina, Maggy; Su, Lijing; Pratt, David; Bu, Chun Hui; Hildebrand, Sara; Lyon, Stephen; Scott, Lindsay; Quan, Jiexia; Sun, Qihua; Russell, Jamie (December 7, 2015). "NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component". Nature Immunology. 17 (3): 250–258. doi:10.1038/ni.3333. ISSN 1529-2916. PMC 4862588. PMID 26642356.
Sun, Lei; Jiang, Zhengfan; Acosta-Rodriguez, Victoria A.; Berger, Michael; Du, Xin; Choi, Jin Huk; Wang, Jianhui; Wang, Kuan-Wen; Kilaru, Gokhul K.; Mohawk, Jennifer A.; Quan, Jiexia; Scott, Lindsay; Hildebrand, Sara; Li, Xiaohong; Tang, Miao (November 6, 2017). "HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections". The Journal of Experimental Medicine. 214 (11): 3263–3277. doi:10.1084/jem.20161630. ISSN 1540-9538. PMC 5679162. PMID 28970238.
Shi, Hexin; Sun, Lei; Wang, Ying; Liu, Aijie; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Hildebrand, Sara; Quan, Jiexia; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (March 2, 2021). "N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization". Nature Communications. 12 (1): 1379. Bibcode:2021NatCo..12.1379S. doi:10.1038/s41467-021-21711-5. ISSN 2041-1723. PMC 7925594. PMID 33654074.
Kim, You-Me; Brinkmann, Melanie M.; Paquet, Marie-Eve; Ploegh, Hidde L. (March 13, 2008). "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes". Nature. 452 (7184): 234–238. Bibcode:2008Natur.452..234K. doi:10.1038/nature06726. ISSN 1476-4687. PMID 18305481. S2CID 4397023.
Casrouge, Armanda; Zhang, Shen-Ying; Eidenschenk, Céline; Jouanguy, Emmanuelle; Puel, Anne; Yang, Kun; Alcais, Alexandre; Picard, Capucine; Mahfoufi, Nora; Nicolas, Nathalie; Lorenzo, Lazaro; Plancoulaine, Sabine; Sénéchal, Brigitte; Geissmann, Frédéric; Tabeta, Koichi (October 13, 2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797): 308–312. Bibcode:2006Sci...314..308C. doi:10.1126/science.1128346. ISSN 1095-9203. PMID 16973841. S2CID 12501759.
Blasius, Amanda L.; Arnold, Carrie N.; Georgel, Philippe; Rutschmann, Sophie; Xia, Yu; Lin, Pei; Ross, Charles; Li, Xiaohong; Smart, Nora G.; Beutler, Bruce (November 16, 2010). "Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19973–19978. Bibcode:2010PNAS..10719973B. doi:10.1073/pnas.1014051107. ISSN 1091-6490. PMC 2993408. PMID 21045126.
Beutler, Bruce; Crozat, Karine; Koziol, James A.; Georgel, Philippe (February 2005). "Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model". Current Opinion in Immunology. 17 (1): 36–43. doi:10.1016/j.coi.2004.11.004. ISSN 0952-7915. PMID 15653308.
Beutler, Bruce; Eidenschenk, Celine; Crozat, Karine; Imler, Jean-Luc; Takeuchi, Osamu; Hoffmann, Jules A.; Akira, Shizuo (October 2007). "Genetic analysis of resistance to viral infection". Nature Reviews. Immunology. 7 (10): 753–766. doi:10.1038/nri2174. ISSN 1474-1741. PMID 17893693. S2CID 37705652.
Brandl, Katharina; Rutschmann, Sophie; Li, Xiaohong; Du, Xin; Xiao, Nengming; Schnabl, Bernd; Brenner, David A.; Beutler, Bruce (March 3, 2009). "Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3300–3305. Bibcode:2009PNAS..106.3300B. doi:10.1073/pnas.0813036106. ISSN 1091-6490. PMC 2651297. PMID 19202076.
Brandl, Katharina; Sun, Lei; Neppl, Christina; Siggs, Owen M.; Le Gall, Sylvain M.; Tomisato, Wataru; Li, Xiaohong; Du, Xin; Maennel, Daniela N.; Blobel, Carl P.; Beutler, Bruce (November 16, 2010). "MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands". Proceedings of the National Academy of Sciences of the United States of America. 107 (46): 19967–19972. Bibcode:2010PNAS..10719967B. doi:10.1073/pnas.1014669107. ISSN 1091-6490. PMC 2993336. PMID 21041656.
Brandl, Katharina; Tomisato, Wataru; Li, Xiaohong; Neppl, Christina; Pirie, Elaine; Falk, Werner; Xia, Yu; Moresco, Eva Marie Y.; Baccala, Roberto; Theofilopoulos, Argyrios N.; Schnabl, Bernd; Beutler, Bruce (July 31, 2012). "Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12650–12655. Bibcode:2012PNAS..10912650B. doi:10.1073/pnas.1210366109. ISSN 1091-6490. PMC 3412000. PMID 22802641.
McAlpine, William; Sun, Lei; Wang, Kuan-Wen; Liu, Aijie; Jain, Ruchi; San Miguel, Miguel; Wang, Jianhui; Zhang, Zhao; Hayse, Braden; McAlpine, Sarah Grace; Choi, Jin Huk; Zhong, Xue; Ludwig, Sara; Russell, Jamie; Zhan, Xiaoming (December 4, 2018). "Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function". Proceedings of the National Academy of Sciences of the United States of America. 115 (49): E11523 – E11531. Bibcode:2018PNAS..11511523M. doi:10.1073/pnas.1814753115. ISSN 1091-6490. PMC 6298088. PMID 30442666.
McAlpine, William; Wang, Kuan-Wen; Choi, Jin Huk; San Miguel, Miguel; McAlpine, Sarah Grace; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao; Bu, Chun Hui; Murray, Anne R.; Moresco, Eva Marie Y. (September 27, 2018). "The class I myosin MYO1D binds to lipid and protects against colitis". Disease Models & Mechanisms. 11 (9): dmm035923. doi:10.1242/dmm.035923. ISSN 1754-8411. PMC 6176994. PMID 30279225.
Wang, Kuan-Wen; Zhan, Xiaoming; McAlpine, William; Zhang, Zhao; Choi, Jin Huk; Shi, Hexin; Misawa, Takuma; Yue, Tao; Zhang, Duanwu; Wang, Ying; Ludwig, Sara; Russell, Jamie; Tang, Miao; Li, Xiaohong; Murray, Anne R. (June 4, 2019). "Enhanced susceptibility to chemically induced colitis caused by excessive endosomal TLR signaling in LRBA-deficient mice". Proceedings of the National Academy of Sciences of the United States of America. 116 (23): 11380–11389. Bibcode:2019PNAS..11611380W. doi:10.1073/pnas.1901407116. ISSN 1091-6490. PMC 6561264. PMID 31097594.
Turer, Emre; McAlpine, William; Wang, Kuan-Wen; Lu, Tianshi; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Murray, Anne R.; Beutler, Bruce (February 14, 2017). "Creatine maintains intestinal homeostasis and protects against colitis". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1273 – E1281. Bibcode:2017PNAS..114E1273T. doi:10.1073/pnas.1621400114. ISSN 1091-6490. PMC 5321020. PMID 28137860.
SoRelle, Jeffrey A.; Chen, Zhe; Wang, Jianhui; Yue, Tao; Choi, Jin Huk; Wang, Kuan-Wen; Zhong, Xue; Hildebrand, Sara; Russell, Jamie; Scott, Lindsay; Xu, Darui; Zhan, Xiaowei; Bu, Chun Hui; Wang, Tao; Choi, Mihwa (April 2021). "Dominant atopy risk mutations identified by mouse forward genetic analysis". Allergy. 76 (4): 1095–1108. doi:10.1111/all.14564. ISSN 1398-9995. PMC 7889751. PMID 32810290.
Chatenoud, Lucienne; Marquet, Cindy; Valette, Fabrice; Scott, Lindsay; Quan, Jiexia; Bu, Chun Hui; Hildebrand, Sara; Moresco, Eva Marie Y.; Bach, Jean-François; Beutler, Bruce (June 1, 2022). "Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice". Disease Models & Mechanisms. 15 (6): dmm049484. doi:10.1242/dmm.049484. ISSN 1754-8411. PMC 9178510. PMID 35502705.
Foray, Anne-Perrine; Candon, Sophie; Hildebrand, Sara; Marquet, Cindy; Valette, Fabrice; Pecquet, Coralie; Lemoine, Sebastien; Langa-Vives, Francina; Dumas, Michael; Hu, Peipei; Santamaria, Pere; You, Sylvaine; Lyon, Stephen; Scott, Lindsay; Bu, Chun Hui (November 23, 2021). "De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes". Proceedings of the National Academy of Sciences of the United States of America. 118 (47): e2112032118. Bibcode:2021PNAS..11812032F. doi:10.1073/pnas.2112032118. ISSN 1091-6490. PMC 8617500. PMID 34782469.
Zhang, Zhao; Turer, Emre; Li, Xiaohong; Zhan, Xiaoming; Choi, Mihwa; Tang, Miao; Press, Amanda; Smith, Steven R.; Divoux, Adeline; Moresco, Eva Marie Y.; Beutler, Bruce (October 18, 2016). "Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice". Proceedings of the National Academy of Sciences of the United States of America. 113 (42): E6418 – E6426. Bibcode:2016PNAS..113E6418Z. doi:10.1073/pnas.1614467113. ISSN 1091-6490. PMC 5081616. PMID 27708159.
Turer, Emre E.; San Miguel, Miguel; Wang, Kuan-Wen; McAlpine, William; Ou, Feiya; Li, Xiaohong; Tang, Miao; Zang, Zhao; Wang, Jianhui; Hayse, Braden; Evers, Bret; Zhan, Xiaoming; Russell, Jamie; Beutler, Bruce (December 18, 2018). "A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis". Disease Models & Mechanisms. 11 (12): dmm035451. doi:10.1242/dmm.035451. ISSN 1754-8411. PMC 6307907. PMID 30563851.
Zhang, Zhao; Jiang, Yiao; Su, Lijing; Ludwig, Sara; Zhang, Xuechun; Tang, Miao; Li, Xiaohong; Anderton, Priscilla; Zhan, Xiaoming; Choi, Mihwa; Russell, Jamie; Bu, Chun-Hui; Lyon, Stephen; Xu, Darui; Hildebrand, Sara (November 1, 2022). "Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis". Cell Metabolism. 34 (11): 1860–1874.e4. doi:10.1016/j.cmet.2022.09.018. ISSN 1932-7420. PMC 9633419. PMID 36228616.
Berger, Michael; Krebs, Philippe; Crozat, Karine; Li, Xiaohong; Croker, Ben A.; Siggs, Owen M.; Popkin, Daniel; Du, Xin; Lawson, Brian R.; Theofilopoulos, Argyrios N.; Xia, Yu; Khovananth, Kevin; Moresco, Eva Marie; Satoh, Takashi; Takeuchi, Osamu (April 2010). "An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence". Nature Immunology. 11 (4): 335–343. doi:10.1038/ni.1847. ISSN 1529-2916. PMC 2861894. PMID 20190759.
Siggs, Owen M.; Arnold, Carrie N.; Huber, Christoph; Pirie, Elaine; Xia, Yu; Lin, Pei; Nemazee, David; Beutler, Bruce (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–440. doi:10.1038/ni.2012. ISSN 1529-2916. PMC 3079768. PMID 21423172.
Siggs, Owen M.; Li, Xiaohong; Xia, Yu; Beutler, Bruce (January 16, 2012). "ZBTB1 is a determinant of lymphoid development". The Journal of Experimental Medicine. 209 (1): 19–27. doi:10.1084/jem.20112084. ISSN 1540-9538. PMC 3260866. PMID 22201126.
Choi, Jin Huk; Han, Jonghee; Theodoropoulos, Panayotis C.; Zhong, Xue; Wang, Jianhui; Medler, Dawson; Ludwig, Sara; Zhan, Xiaoming; Li, Xiaohong; Tang, Miao; Gallagher, Thomas; Yu, Gang; Beutler, Bruce (March 3, 2020). "Essential requirement for nicastrin in marginal zone and B-1 B cell development". Proceedings of the National Academy of Sciences of the United States of America. 117 (9): 4894–4901. Bibcode:2020PNAS..117.4894C. doi:10.1073/pnas.1916645117. ISSN 1091-6490. PMC 7060662. PMID 32071239.
Choi, Jin Huk; Zhong, Xue; McAlpine, William; Liao, Tzu-Chieh; Zhang, Duanwu; Fang, Beibei; Russell, Jamie; Ludwig, Sara; Nair-Gill, Evan; Zhang, Zhao; Wang, Kuan-Wen; Misawa, Takuma; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao (May 10, 2019). "LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling". Science. 364 (6440): eaau0812. doi:10.1126/science.aau0812. ISSN 1095-9203. PMC 7206793. PMID 31073040.
Choi, Jin Huk; Zhong, Xue; Zhang, Zhao; Su, Lijing; McAlpine, William; Misawa, Takuma; Liao, Tzu-Chieh; Zhan, Xiaoming; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Moresco, Eva Marie Y.; Beutler, Bruce (April 6, 2020). "Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development". The Journal of Experimental Medicine. 217 (4): e20190006. doi:10.1084/jem.20190006. ISSN 1540-9538. PMC 7144532. PMID 31985756.
Zhang, Duanwu; Yue, Tao; Choi, Jin Huk; Nair-Gill, Evan; Zhong, Xue; Wang, Kuan-Wen; Zhan, Xiaoming; Li, Xiaohong; Choi, Mihwa; Tang, Miao; Quan, Jiexia; Hildebrand, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (October 2019). "Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40". Nature Immunology. 20 (10): 1322–1334. doi:10.1038/s41590-019-0464-4. ISSN 1529-2916. PMC 7179765. PMID 31427773.
Zhong, Xue; Choi, Jin Huk; Hildebrand, Sara; Ludwig, Sara; Wang, Jianhui; Nair-Gill, Evan; Liao, Tzu-Chieh; Moresco, James J.; Liu, Aijie; Quan, Jiexia; Sun, Qihua; Zhang, Duanwu; Zhan, Xiaoming; Choi, Mihwa; Li, Xiaohong (May 3, 2022). "RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice". Proceedings of the National Academy of Sciences of the United States of America. 119 (18): e2200128119. Bibcode:2022PNAS..11900128Z. doi:10.1073/pnas.2200128119. ISSN 1091-6490. PMC 9170173. PMID 35482923.
Zhong, Xue; Su, Lijing; Yang, Yi; Nair-Gill, Evan; Tang, Miao; Anderton, Priscilla; Li, Xiaohong; Wang, Jianhui; Zhan, Xiaoming; Tomchick, Diana R.; Brautigam, Chad A.; Moresco, Eva Marie Y.; Choi, Jin Huk; Beutler, Bruce (April 14, 2020). "Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function". Proceedings of the National Academy of Sciences of the United States of America. 117 (15): 8563–8572. Bibcode:2020PNAS..117.8563Z. doi:10.1073/pnas.2000703117. ISSN 1091-6490. PMC 7165429. PMID 32220963.
Misawa, Takuma; SoRelle, Jeffrey A.; Choi, Jin Huk; Yue, Tao; Wang, Kuan-Wen; McAlpine, William; Wang, Jianhui; Liu, Aijie; Tabeta, Koichi; Turer, Emre E.; Evers, Bret; Nair-Gill, Evan; Poddar, Subhajit; Su, Lijing; Ou, Feiya (January 24, 2020). "Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation". Science Immunology. 5 (43): eaaz0085. doi:10.1126/sciimmunol.aaz0085. ISSN 2470-9468. PMC 7278039. PMID 31980486.
Arnold, Carrie N.; Pirie, Elaine; Dosenovic, Pia; McInerney, Gerald M.; Xia, Yu; Wang, Nathaniel; Li, Xiaohong; Siggs, Owen M.; Karlsson Hedestam, Gunilla B.; Beutler, Bruce (July 31, 2012). "A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12286–12293. doi:10.1073/pnas.1209134109. ISSN 1091-6490. PMC 3411946. PMID 22761313.
Choi, Jin Huk; Wang, Kuan-Wen; Zhang, Duanwu; Zhan, Xiaowei; Wang, Tao; Bu, Chun-Hui; Behrendt, Cassie L.; Zeng, Ming; Wang, Ying; Misawa, Takuma; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Scott, Lindsay; Hildebrand, Sara (February 14, 2017). "IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice". Proceedings of the National Academy of Sciences of the United States of America. 114 (7): E1196 – E1204. Bibcode:2017PNAS..114E1196C. doi:10.1073/pnas.1621258114. ISSN 1091-6490. PMC 5321007. PMID 28137874.
Yue, Tao; Zhan, Xiaoming; Zhang, Duanwu; Jain, Ruchi; Wang, Kuan-Wen; Choi, Jin Huk; Misawa, Takuma; Su, Lijing; Quan, Jiexia; Hildebrand, Sara; Xu, Darui; Li, Xiaohong; Turer, Emre; Sun, Lei; Moresco, Eva Marie Y. (May 14, 2021). "SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity". Science. 372 (6543): eaba4220. doi:10.1126/science.aba4220. ISSN 1095-9203. PMC 8442736. PMID 33986151.
Nair-Gill, Evan; Bonora, Massimo; Zhong, Xue; Liu, Aijie; Miranda, Amber; Stewart, Nathan; Ludwig, Sara; Russell, Jamie; Gallagher, Thomas; Pinton, Paolo; Beutler, Bruce (May 3, 2021). "Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases". The EMBO Journal. 40 (9): e104888. doi:10.15252/embj.2020104888. ISSN 1460-2075. PMC 8090855. PMID 33630350.
Blasius, Amanda L.; Brandl, Katharina; Crozat, Karine; Xia, Yu; Khovananth, Kevin; Krebs, Philippe; Smart, Nora G.; Zampolli, Antonella; Ruggeri, Zaverio M.; Beutler, Bruce A. (February 24, 2009). "Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2706–2711. Bibcode:2009PNAS..106.2706B. doi:10.1073/pnas.0813208106. ISSN 1091-6490. PMC 2650330. PMID 19202056.
Rutschmann, Sophie; Crozat, Karine; Li, Xiaohong; Du, Xin; Hanselman, Jeffrey C.; Shigeoka, Alana A.; Brandl, Katharina; Popkin, Daniel L.; McKay, Dianne B.; Xia, Yu; Moresco, Eva Marie Y.; Beutler, Bruce (April 2012). "Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice". G3: Genes, Genomes, Genetics. 2 (4): 499–504. doi:10.1534/g3.112.002196. ISSN 2160-1836. PMC 3337478. PMID 22540041.
Chen, Zhe; Holland, William; Shelton, John M.; Ali, Aktar; Zhan, Xiaoming; Won, Sungyong; Tomisato, Wataru; Liu, Chen; Li, Xiaohong; Moresco, Eva Marie Y.; Beutler, Bruce (May 20, 2014). "Mutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling". Proceedings of the National Academy of Sciences of the United States of America. 111 (20): 7367–7372. Bibcode:2014PNAS..111.7367C. doi:10.1073/pnas.1406511111. ISSN 1091-6490. PMC 4034201. PMID 24799716.
Zhang, Zhao; Gallagher, Thomas; Scherer, Philipp E.; Beutler, Bruce (May 26, 2020). "Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome". Proceedings of the National Academy of Sciences of the United States of America. 117 (21): 11829–11835. Bibcode:2020PNAS..11711829Z. doi:10.1073/pnas.2000118117. ISSN 1091-6490. PMC 7260979. PMID 32381739.
Zhang, Zhao; Xun, Yu; Rong, Shunxing; Yan, Lijuan; SoRelle, Jeffrey A.; Li, Xiaohong; Tang, Miao; Keller, Katie; Ludwig, Sara; Moresco, Eva Marie Y.; Beutler, Bruce (July 16, 2022). "Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity". Nature Communications. 13 (1): 4136. Bibcode:2022NatCo..13.4136Z. doi:10.1038/s41467-022-31812-4. ISSN 2041-1723. PMC 9288484. PMID 35842425.
Smyth, Ian; Du, Xin; Taylor, Martin S.; Justice, Monica J.; Beutler, Bruce; Jackson, Ian J. (September 14, 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proceedings of the National Academy of Sciences of the United States of America. 101 (37): 13560–13565. Bibcode:2004PNAS..10113560S. doi:10.1073/pnas.0402760101. ISSN 0027-8424. PMC 518794. PMID 15345741.
Al-Fadhli, Fatima M.; Afqi, Manal; Sairafi, Mona Hamza; Almuntashri, Makki; Alharby, Essa; Alharbi, Ghadeer; Abdud Samad, Firoz; Hashmi, Jamil Amjad; Zaytuni, Dimah; Bahashwan, Ahmed A.; Choi, Jin Huk; Peake, Roy W. A.; Beutler, Bruce; Almontashiri, Naif A. M. (May 2021). "Biallelic loss of function variant in the unfolded protein response gene PDIA6 is associated with asphyxiating thoracic dystrophy and neonatal-onset diabetes". Clinical Genetics. 99 (5): 694–703. doi:10.1111/cge.13930. ISSN 1399-0004. PMID 33495992. S2CID 231710148.
Israel, Laura; Wang, Ying; Bulek, Katarzyna; Della Mina, Erika; Zhang, Zhao; Pedergnana, Vincent; Chrabieh, Maya; Lemmens, Nicole A.; Sancho-Shimizu, Vanessa; Descatoire, Marc; Lasseau, Théo; Israelsson, Elisabeth; Lorenzo, Lazaro; Yun, Ling; Belkadi, Aziz (February 23, 2017). "Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity". Cell. 168 (5): 789–800.e10. doi:10.1016/j.cell.2017.01.039. ISSN 1097-4172. PMC 5328639. PMID 28235196.
Melis, Maria Antonietta; Cau, Milena; Congiu, Rita; Sole, Gabriella; Barella, Susanna; Cao, Antonio; Westerman, Mark; Cazzola, Mario; Galanello, Renzo (October 2008). "A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron". Haematologica. 93 (10): 1473–1479. doi:10.3324/haematol.13342. ISSN 1592-8721. PMID 18603562. S2CID 23364362.
El Hayek, Lauretta; Tuncay, Islam Oguz; Nijem, Nadine; Russell, Jamie; Ludwig, Sara; Kaur, Kiran; Li, Xiaohong; Anderton, Priscilla; Tang, Miao; Gerard, Amanda; Heinze, Anja; Zacher, Pia; Alsaif, Hessa S.; Rad, Aboulfazl; Hassanpour, Kazem (December 22, 2020). "KDM5A mutations identified in autism spectrum disorder using forward genetics". eLife. 9: e56883. doi:10.7554/eLife.56883. ISSN 2050-084X. PMC 7755391. PMID 33350388.
Rios, Jonathan J.; Denton, Kristin; Yu, Hao; Manickam, Kandamurugu; Garner, Shannon; Russell, Jamie; Ludwig, Sara; Rosenfeld, Jill A.; Liu, Pengfei; Munch, Jake; Sucato, Daniel J.; Beutler, Bruce; Wise, Carol A. (June 1, 2021). "Saturation mutagenesis defines novel mouse models of severe spine deformity". Disease Models & Mechanisms. 14 (6): dmm048901. doi:10.1242/dmm.048901. ISSN 1754-8411. PMC 8246263. PMID 34142127.
Rios, Jonathan J.; Denton, Kristin; Russell, Jamie; Kozlitina, Julia; Ferreira, Carlos R.; Lewanda, Amy F.; Mayfield, Joshua E.; Moresco, Eva; Ludwig, Sara; Tang, Miao; Li, Xiaohong; Lyon, Stephen; Khanshour, Anas; Paria, Nandina; Khalid, Aysha (August 2021). "Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice". Journal of Bone and Mineral Research. 36 (8): 1548–1565. doi:10.1002/jbmr.4323. ISSN 1523-4681. PMC 8862308. PMID 33905568.
Andrews, T. D.; Whittle, B.; Field, M. A.; Balakishnan, B.; Zhang, Y.; Shao, Y.; Cho, V.; Kirk, M.; Singh, M.; Xia, Y.; Hager, J.; Winslade, S.; Sjollema, G.; Beutler, B.; Enders, A. (May 2012). "Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models". Open Biology. 2 (5): 120061. doi:10.1098/rsob.120061. ISSN 2046-2441. PMC 3376740. PMID 22724066.
Bull, Katherine R.; Rimmer, Andrew J.; Siggs, Owen M.; Miosge, Lisa A.; Roots, Carla M.; Enders, Anselm; Bertram, Edward M.; Crockford, Tanya L.; Whittle, Belinda; Potter, Paul K.; Simon, Michelle M.; Mallon, Ann-Marie; Brown, Steve D. M.; Beutler, Bruce; Goodnow, Christopher C. (2013). "Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations". PLOS Genetics. 9 (1): e1003219. doi:10.1371/journal.pgen.1003219. ISSN 1553-7404. PMC 3561070. PMID 23382690.
Xia, Yu; Won, Sungyong; Du, Xin; Lin, Pei; Ross, Charles; La Vine, Diantha; Wiltshire, Sean; Leiva, Gabriel; Vidal, Silvia M.; Whittle, Belinda; Goodnow, Christopher C.; Koziol, James; Moresco, Eva Marie Y.; Beutler, Bruce (December 2010). "Bulk segregation mapping of mutations in closely related strains of mice". Genetics. 186 (4): 1139–1146. doi:10.1534/genetics.110.121160. ISSN 1943-2631. PMC 2998299. PMID 20923982.
Wang, Tao; Zhan, Xiaowei; Bu, Chun-Hui; Lyon, Stephen; Pratt, David; Hildebrand, Sara; Choi, Jin Huk; Zhang, Zhao; Zeng, Ming; Wang, Kuan-wen; Turer, Emre; Chen, Zhe; Zhang, Duanwu; Yue, Tao; Wang, Ying (February 3, 2015). "Real-time resolution of point mutations that cause phenovariance in mice". Proceedings of the National Academy of Sciences of the United States of America. 112 (5): E440–449. Bibcode:2015PNAS..112E.440W. doi:10.1073/pnas.1423216112. ISSN 1091-6490. PMC 4321302. PMID 25605905.
Wang, Tao; Bu, Chun Hui; Hildebrand, Sara; Jia, Gaoxiang; Siggs, Owen M.; Lyon, Stephen; Pratt, David; Scott, Lindsay; Russell, Jamie; Ludwig, Sara; Murray, Anne R.; Moresco, Eva Marie Y.; Beutler, Bruce (January 30, 2018). "Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database". Nature Communications. 9 (1): 441. Bibcode:2018NatCo...9..441W. doi:10.1038/s41467-017-02806-4. ISSN 2041-1723. PMC 5789985. PMID 29382827.
Xu, Darui; Lyon, Stephen; Bu, Chun Hui; Hildebrand, Sara; Choi, Jin Huk; Zhong, Xue; Liu, Aijie; Turer, Emre E.; Zhang, Zhao; Russell, Jamie; Ludwig, Sara; Mahrt, Elena; Nair-Gill, Evan; Shi, Hexin; Wang, Ying (July 13, 2021). "Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning". Proceedings of the National Academy of Sciences of the United States of America. 118 (28): e2106786118. Bibcode:2021PNAS..11806786X. doi:10.1073/pnas.2106786118. ISSN 1091-6490. PMC 8285956. PMID 34260399.
Chen, Bo; Aredo, Bogale; Ding, Yi; Zhong, Xin; Zhu, Yuanfei; Zhao, Cynthia X.; Kumar, Ashwani; Xing, Chao; Gautron, Laurent; Lyon, Stephen; Russell, Jamie; Li, Xiaohong; Tang, Miao; Anderton, Priscilla; Ludwig, Sara (June 9, 2020). "Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 12931–12942. Bibcode:2020PNAS..11712931C. doi:10.1073/pnas.1921224117. ISSN 1091-6490. PMC 7293615. PMID 32457148.
Wang, Yibing; Cao, Liqin; Lee, Chia-Ying; Matsuo, Tomohiko; Wu, Kejia; Asher, Greg; Tang, Lijun; Saitoh, Tsuyoshi; Russell, Jamie; Klewe-Nebenius, Daniela; Wang, Li; Soya, Shingo; Hasegawa, Emi; Chérasse, Yoan; Zhou, Jiamin (May 23, 2018). "Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors". Nature Communications. 9 (1): 2041. Bibcode:2018NatCo...9.2041W. doi:10.1038/s41467-018-04324-3. ISSN 2041-1723. PMC 5966455. PMID 29795268.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Mifune, Yuto; Su, Lijing; Shi, Hexin; Moresco, Eva Marie Y.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (October 31, 2018). "Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists". Journal of the American Chemical Society. 140 (43): 14440–14454. doi:10.1021/jacs.8b09223. ISSN 1520-5126. PMC 6209530. PMID 30272974.
Morin, Matthew D.; Wang, Ying; Jones, Brian T.; Su, Lijing; Surakattula, Murali M. R. P.; Berger, Michael; Huang, Hua; Beutler, Elliot K.; Zhang, Hong; Beutler, Bruce; Boger, Dale L. (May 26, 2016). "Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists". Journal of Medicinal Chemistry. 59 (10): 4812–4830. doi:10.1021/acs.jmedchem.6b00177. ISSN 1520-4804. PMC 4882283. PMID 27050713.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Mifune, Yuto; Shi, Hexin; Wang, Kuan-Wen; Zhan, Xiaoming; Liu, Aijie; Wang, Jianhui; Li, Xiaohong; Tang, Miao; Ludwig, Sara; Hildebrand, Sara; Zhou, Kejin (September 11, 2018). "Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice". Proceedings of the National Academy of Sciences of the United States of America. 115 (37): E8698 – E8706. Bibcode:2018PNAS..115E8698W. doi:10.1073/pnas.1809232115. ISSN 1091-6490. PMC 6140543. PMID 30150374.
Wang, Ying; Su, Lijing; Morin, Matthew D.; Jones, Brian T.; Whitby, Landon R.; Surakattula, Murali M. R. P.; Huang, Hua; Shi, Hexin; Choi, Jin Huk; Wang, Kuan-wen; Moresco, Eva Marie Y.; Berger, Michael; Zhan, Xiaoming; Zhang, Hong; Boger, Dale L. (February 16, 2016). "TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS". Proceedings of the National Academy of Sciences of the United States of America. 113 (7): E884–893. Bibcode:2016PNAS..113E.884W. doi:10.1073/pnas.1525639113. ISSN 1091-6490. PMC 4763747. PMID 26831104.
Su, Lijing; Athamna, Muhammad; Wang, Ying; Wang, Junmei; Freudenberg, Marina; Yue, Tao; Wang, Jianhui; Moresco, Eva Marie Y.; He, Haoming; Zor, Tsaffrir; Beutler, Bruce (July 27, 2021). "Sulfatides are endogenous ligands for the TLR4-MD-2 complex". Proceedings of the National Academy of Sciences of the United States of America. 118 (30): e2105316118. Bibcode:2021PNAS..11805316S. doi:10.1073/pnas.2105316118. ISSN 1091-6490. PMC 8325290. PMID 34290146.
Su, Lijing; Wang, Ying; Wang, Junmei; Mifune, Yuto; Morin, Matthew D.; Jones, Brian T.; Moresco, Eva Marie Y.; Boger, Dale L.; Beutler, Bruce; Zhang, Hong (March 28, 2019). "Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim". Journal of Medicinal Chemistry. 62 (6): 2938–2949. doi:10.1021/acs.jmedchem.8b01583. ISSN 1520-4804. PMC 6537610. PMID 30829478.
Yang, Ming-Hsiu; Russell, Jamie L.; Mifune, Yuto; Wang, Ying; Shi, Hexin; Moresco, Eva Marie Y.; Siegwart, Daniel J.; Beutler, Bruce; Boger, Dale L. (July 14, 2022). "Next-Generation Diprovocims with Potent Human and Murine TLR1/TLR2 Agonist Activity That Activate the Innate and Adaptive Immune Response". Journal of Medicinal Chemistry. 65 (13): 9230–9252. doi:10.1021/acs.jmedchem.2c00419. ISSN 1520-4804. PMC 9283309. PMID 35767437.
Beutler, Bruce (January 1, 2009). "Ernest Beutler (1928–2008)". Haematologica. 94 (1): 154–156. doi:10.3324/haematol.13863. ISSN 1592-8721. PMC 2625414. PMID 19118377. S2CID 43531611.
Beutler, E. (February 1959). "The hemolytic effect of primaquine and related compounds: a review". Blood. 14 (2): 103–139. doi:10.1182/blood.V14.2.103.103. ISSN 0006-4971. PMID 13618370.
Beutler, E (February 1961). "Hematology: Iron Metabolism". Annual Review of Medicine. 12 (1): 195–210. doi:10.1146/annurev.me.12.020161.001211. ISSN 0066-4219.
Beutler, Ernest (July 2006). "Lysosomal storage diseases: natural history and ethical and economic aspects". Molecular Genetics and Metabolism. 88 (3): 208–215. doi:10.1016/j.ymgme.2006.01.010. ISSN 1096-7192. PMID 16515872.
Beutler, E.; Blume, K. G.; Bross, K. J.; Chillar, R. K.; Ellington, O. B.; Fahey, J. L.; Farbstein, M. J.; Schmidt, G. M.; Spruce, W. E.; Turner, M. A. (1979). "Bone marrow transplantation as the treatment of choice for "good risk" adult patients with acute leukemia". Transactions of the Association of American Physicians. 92: 189–195. ISSN 0066-9458. PMID 398617.
Piro, L. D.; Carrera, C. J.; Carson, D. A.; Beutler, E. (April 19, 1990). "Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine". The New England Journal of Medicine. 322 (16): 1117–1121. doi:10.1056/NEJM199004193221605. ISSN 0028-4793. PMID 1969613.
Beutler, E.; Yeh, M.; Fairbanks, V. F. (January 15, 1962). "The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker". Proceedings of the National Academy of Sciences of the United States of America. 48 (1): 9–16. Bibcode:1962PNAS...48....9B. doi:10.1073/pnas.48.1.9. ISSN 0027-8424. PMC 285481. PMID 13868717.
Beutler, Bruce; Beutler, Ernest (December 12, 2002). "Toll-like receptor 4 polymorphisms and atherogenesis". The New England Journal of Medicine. 347 (24): 1978–1980, author reply 1978–1980. doi:10.1056/NEJM200212123472416. ISSN 1533-4406. PMID 12479194.
Beutler, E.; Gelbart, T.; Han, J. H.; Koziol, J. A.; Beutler, B. (January 1989). "Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage". Proceedings of the National Academy of Sciences of the United States of America. 86 (1): 192–196. Bibcode:1989PNAS...86..192B. doi:10.1073/pnas.86.1.192. ISSN 0027-8424. PMC 286430. PMID 2463621.
Truksa, Jaroslav; Gelbart, Terri; Peng, Hongfan; Beutler, Ernest; Beutler, Bruce; Lee, Pauline (November 2009). "Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6". British Journal of Haematology. 147 (4): 571–581. doi:10.1111/j.1365-2141.2009.07873.x. ISSN 1365-2141. PMID 19751239. S2CID 205266224.
Du, Xin; She, Ellen; Gelbart, Terri; Truksa, Jaroslav; Lee, Pauline; Xia, Yu; Khovananth, Kevin; Mudd, Suzanne; Mann, Navjiwan; Moresco, Eva Marie Y.; Beutler, Ernest; Beutler, Bruce (May 23, 2008). "The serine protease TMPRSS6 is required to sense iron deficiency". Science. 320 (5879): 1088–1092. Bibcode:2008Sci...320.1088D. doi:10.1126/science.1157121. ISSN 1095-9203. PMC 2430097. PMID 18451267.
Hildebrandt, Sabine; Kammertöns, Thomas; Lechner, Christian; Schmitt, Philipp; Schumann, Ralf R. (2019). "Dr. Käthe Beutler, 1896–1999". Medizinhistorisches Journal. 54 (4): 294–346. doi:10.25162/mhj-2019-0009. ISSN 0025-8431. S2CID 213008951.