CYP2R1 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "CYP2R1" in English language version.

refsWebsite

Global rank English rank

22nih.gov

4^th place

11doi.org

2^nd place

2ensembl.org

1,626^th place

1,007^th place

2harvard.edu

18^th place

17^th place

2semanticscholar.org

11^th place

8^th place

1wikipathways.org

low place

1mousephenotype.org

low place

doi.org

Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW (September 2003). "De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase". J Biol Chem. 278 (39): 38084–93. doi:10.1074/jbc.M307028200. PMC 4450819. PMID 12867411.
Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW (May 2004). "Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase". Proc Natl Acad Sci U S A. 101 (20): 7711–5. Bibcode:2004PNAS..101.7711C. doi:10.1073/pnas.0402490101. PMC 419671. PMID 15128933.
Bikle DD (March 2014). "Vitamin D metabolism, mechanism of action, and clinical applications". Chemistry & Biology. 21 (3): 319–29. doi:10.1016/j.chembiol.2013.12.016. PMC 3968073. PMID 24529992.
Bouillon R, Bikle D (November 2019). "Vitamin D Metabolism Revised: Fall of Dogmas". Journal of Bone and Mineral Research (Review). 34 (11): 1985–1992. doi:10.1002/jbmr.3884. PMC 9000993. PMID 31589774.
Nelson DR (Dec 2002). "Comparison of P450s from human and fugu: 420 million years of vertebrate P450 evolution". Arch Biochem Biophys. 409 (1): 18–24. doi:10.1016/S0003-9861(02)00553-2. PMID 12464240.
Ramos-Lopez E, Brück P, Jansen T, et al. (2008). "CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans". Diabetes Metab. Res. Rev. 23 (8): 631–6. doi:10.1002/dmrr.719. PMID 17607662. S2CID 376070.
Manousaki D, Dudding T, Haworth S, Hsu YH, Liu CT, Medina-Gómez C, et al. (December 2018). "Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis". American Journal of Human Genetics. 103 (6): 1053. doi:10.1016/j.ajhg.2018.11.010. PMC 6288274. PMID 30526863.
Thacher TD, Levine MA (October 2017). "CYP2R1 mutations causing vitamin D-deficiency rickets". J Steroid Biochem Mol Biol. 173: 333–336. doi:10.1016/j.jsbmb.2016.07.014. PMID 27473561. S2CID 1693344.
Molin A, Wiedemann A, Demers N, Kaufmann M, Do Cao J, Mainard L, et al. (September 2017). "Vitamin D-Dependent Rickets Type 1B (25-Hydroxylase Deficiency): A Rare Condition or a Misdiagnosed Condition?". Journal of Bone and Mineral Research. 32 (9): 1893–1899. doi:10.1002/jbmr.3181. PMID 28548312.
Zhu JG, Ochalek JT, Kaufmann M, Jones G, Deluca HF (September 2013). "CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo". Proc Natl Acad Sci U S A. 110 (39): 15650–5. Bibcode:2013PNAS..11015650Z. doi:10.1073/pnas.1315006110. PMC 3785760. PMID 24019477.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000186104 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030670 – Ensembl, May 2017

harvard.edu

ui.adsabs.harvard.edu

Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW (May 2004). "Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase". Proc Natl Acad Sci U S A. 101 (20): 7711–5. Bibcode:2004PNAS..101.7711C. doi:10.1073/pnas.0402490101. PMC 419671. PMID 15128933.
Zhu JG, Ochalek JT, Kaufmann M, Jones G, Deluca HF (September 2013). "CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo". Proc Natl Acad Sci U S A. 110 (39): 15650–5. Bibcode:2013PNAS..11015650Z. doi:10.1073/pnas.1315006110. PMC 3785760. PMID 24019477.

mousephenotype.org

"Cyp2r1 Mouse Gene Details". www.mousephenotype.org. International Mouse Phenotyping Consortium. Retrieved 8 March 2021.

nih.gov

pubmed.ncbi.nlm.nih.gov

Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW (September 2003). "De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase". J Biol Chem. 278 (39): 38084–93. doi:10.1074/jbc.M307028200. PMC 4450819. PMID 12867411.
Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW (May 2004). "Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase". Proc Natl Acad Sci U S A. 101 (20): 7711–5. Bibcode:2004PNAS..101.7711C. doi:10.1073/pnas.0402490101. PMC 419671. PMID 15128933.
Bikle DD (March 2014). "Vitamin D metabolism, mechanism of action, and clinical applications". Chemistry & Biology. 21 (3): 319–29. doi:10.1016/j.chembiol.2013.12.016. PMC 3968073. PMID 24529992.
Bouillon R, Bikle D (November 2019). "Vitamin D Metabolism Revised: Fall of Dogmas". Journal of Bone and Mineral Research (Review). 34 (11): 1985–1992. doi:10.1002/jbmr.3884. PMC 9000993. PMID 31589774.
Nelson DR (Dec 2002). "Comparison of P450s from human and fugu: 420 million years of vertebrate P450 evolution". Arch Biochem Biophys. 409 (1): 18–24. doi:10.1016/S0003-9861(02)00553-2. PMID 12464240.
Ramos-Lopez E, Brück P, Jansen T, et al. (2008). "CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans". Diabetes Metab. Res. Rev. 23 (8): 631–6. doi:10.1002/dmrr.719. PMID 17607662. S2CID 376070.
Manousaki D, Dudding T, Haworth S, Hsu YH, Liu CT, Medina-Gómez C, et al. (December 2018). "Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis". American Journal of Human Genetics. 103 (6): 1053. doi:10.1016/j.ajhg.2018.11.010. PMC 6288274. PMID 30526863.
Thacher TD, Levine MA (October 2017). "CYP2R1 mutations causing vitamin D-deficiency rickets". J Steroid Biochem Mol Biol. 173: 333–336. doi:10.1016/j.jsbmb.2016.07.014. PMID 27473561. S2CID 1693344.
Molin A, Wiedemann A, Demers N, Kaufmann M, Do Cao J, Mainard L, et al. (September 2017). "Vitamin D-Dependent Rickets Type 1B (25-Hydroxylase Deficiency): A Rare Condition or a Misdiagnosed Condition?". Journal of Bone and Mineral Research. 32 (9): 1893–1899. doi:10.1002/jbmr.3181. PMID 28548312.
Zhu JG, Ochalek JT, Kaufmann M, Jones G, Deluca HF (September 2013). "CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo". Proc Natl Acad Sci U S A. 110 (39): 15650–5. Bibcode:2013PNAS..11015650Z. doi:10.1073/pnas.1315006110. PMC 3785760. PMID 24019477.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW (September 2003). "De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase". J Biol Chem. 278 (39): 38084–93. doi:10.1074/jbc.M307028200. PMC 4450819. PMID 12867411.
Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW (May 2004). "Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase". Proc Natl Acad Sci U S A. 101 (20): 7711–5. Bibcode:2004PNAS..101.7711C. doi:10.1073/pnas.0402490101. PMC 419671. PMID 15128933.
"Entrez Gene: CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1".
Bikle DD (March 2014). "Vitamin D metabolism, mechanism of action, and clinical applications". Chemistry & Biology. 21 (3): 319–29. doi:10.1016/j.chembiol.2013.12.016. PMC 3968073. PMID 24529992.
Bouillon R, Bikle D (November 2019). "Vitamin D Metabolism Revised: Fall of Dogmas". Journal of Bone and Mineral Research (Review). 34 (11): 1985–1992. doi:10.1002/jbmr.3884. PMC 9000993. PMID 31589774.
Manousaki D, Dudding T, Haworth S, Hsu YH, Liu CT, Medina-Gómez C, et al. (December 2018). "Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis". American Journal of Human Genetics. 103 (6): 1053. doi:10.1016/j.ajhg.2018.11.010. PMC 6288274. PMID 30526863.
Zhu JG, Ochalek JT, Kaufmann M, Jones G, Deluca HF (September 2013). "CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo". Proc Natl Acad Sci U S A. 110 (39): 15650–5. Bibcode:2013PNAS..11015650Z. doi:10.1073/pnas.1315006110. PMC 3785760. PMID 24019477.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

ods.od.nih.gov

"Office of Dietary Supplements - Vitamin D". ods.od.nih.gov. 9 October 2020. Retrieved 7 March 2021.

semanticscholar.org

api.semanticscholar.org

Ramos-Lopez E, Brück P, Jansen T, et al. (2008). "CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans". Diabetes Metab. Res. Rev. 23 (8): 631–6. doi:10.1002/dmrr.719. PMID 17607662. S2CID 376070.
Thacher TD, Levine MA (October 2017). "CYP2R1 mutations causing vitamin D-deficiency rickets". J Steroid Biochem Mol Biol. 173: 333–336. doi:10.1016/j.jsbmb.2016.07.014. PMID 27473561. S2CID 1693344.

wikipathways.org

The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".