Analysis of information sources in references of the Wikipedia article "Chlormadinone acetate" in English language version.
The first progesterone derivative 17-acetoxyprogesterone was developed by Schering in 1954 followed by medroxyprogesterone acetate in 1957. This was followed by [megestrol] acetate and chlormadinone acetate in 1959.
In principle, DNA adduct formation is not unique for CPA. DNA adducts in the rat liver were also found after in vitro incubation with megestrol and chlormadinone, as well as after in vivo exposure with both these compounds and with ethinylestradiol. [8-11] However, the adduct level generated by chlormadinone and megestrol is about 30 to 50 times lower than that after CPA.[12] [...] with chlormadinone [acetate] we found 5 liver cell adenomas, 5 focal nodular hyperplasias and 1 liver cell carcinoma.
In principle, DNA adduct formation is not unique for CPA. DNA adducts in the rat liver were also found after in vitro incubation with megestrol and chlormadinone, as well as after in vivo exposure with both these compounds and with ethinylestradiol. [8-11] However, the adduct level generated by chlormadinone and megestrol is about 30 to 50 times lower than that after CPA.[12] [...] with chlormadinone [acetate] we found 5 liver cell adenomas, 5 focal nodular hyperplasias and 1 liver cell carcinoma.
In principle, DNA adduct formation is not unique for CPA. DNA adducts in the rat liver were also found after in vitro incubation with megestrol and chlormadinone, as well as after in vivo exposure with both these compounds and with ethinylestradiol. [8-11] However, the adduct level generated by chlormadinone and megestrol is about 30 to 50 times lower than that after CPA.[12] [...] with chlormadinone [acetate] we found 5 liver cell adenomas, 5 focal nodular hyperplasias and 1 liver cell carcinoma.
