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Crocetin (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Crocetin" in English language version.

refsWebsite
Global rank English rank
17nih.gov
4th place
4th place
16doi.org
2nd place
2nd place
4semanticscholar.org
11th place
8th place
2espacenet.com
800th place
676th place
1clinicaltrials.gov
5,225th place
4,062nd place
1diffusionpharma.com
low place
low place

clinicaltrials.gov

diffusionpharma.com

investors.diffusionpharma.com

doi.org

  • Umigai N, Murakami K, Ulit MV, et al. (May 2011). "The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration". Phytomedicine. 18 (7): 575–8. doi:10.1016/j.phymed.2010.10.019. PMID 21112749.
  • Ichi, T; Higashimura, Y; Katayama, T; Koda, T; Shimizu, T; Tada, M (1995). "Analysis of Crocetin Derivatives from Gardenia". Nippon Shokuhin Kagaku Kogaku Kaishi. 42 (10): 776–783. doi:10.3136/nskkk.42.776. S2CID 87600533.
  • Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU, Jung WS, Cho KH, Park JH, Kang I, Hong JW, Lee EH (2010). "Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells". European Journal of Pharmacology. 648 (1–3): 110–6. doi:10.1016/j.ejphar.2010.09.003. PMID 20854811.
  • Mizuma H, Tanaka M, Nozaki S, Mizuno K, Tahara T, Ataka S, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (March 2009). "Daily oral administration of crocetin attenuates physical fatigue in human subjects". Nutrition Research. 29 (3): 145–50. doi:10.1016/j.nutres.2009.02.003. PMID 19358927.
  • Kuratsune H, Umigai N, Takeno R, Kajimoto Y, Nakano T (September 2010). "Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study". Phytomedicine. 17 (11): 840–3. doi:10.1016/j.phymed.2010.03.025. PMID 20537515.
  • Yamauchi, M; Tsuruma, K; Imai, S; Nakanishi, T; Umigai, N; Shimazawa, M; Hara, H (2011). "Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity". European Journal of Pharmacology. 650 (1): 110–9. doi:10.1016/j.ejphar.2010.09.081. PMID 20951131.
  • Gainer, J (2008). "Trans-sodium crocetinate for treating hypoxia/ischemia". Expert Opinion on Investigational Drugs. 17 (6): 917–924. doi:10.1517/13543784.17.6.917. PMID 18491992. S2CID 71663644.
  • Giassi L; et al. (2001). "Trans-Sodium Crocetinate Restores Blood Pressure, Heart Rate, and Plasma Lactate after Hemorrhagic Shock". Journal of Trauma-Injury Infection & Critical Care. 51 (5): 932–938. doi:10.1097/00005373-200111000-00018. PMID 11706343.
  • Lapchak P (2010). "Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: A combination therapy study with tissue plasminogen activator". Brain Research. 1309: 136–145. doi:10.1016/j.brainres.2009.10.067. PMID 19891959. S2CID 25369069.
  • Mohler E; et al. (2010). "Evaluation of trans sodium crocetinate on safety and exercise performance in patients with peripheral artery disease and intermittent claudication". Vascular Medicine. 16 (5): 346–352. doi:10.1177/1358863X11422742. PMC 4182020. PMID 22003000.
  • Stennett a; et al. (2006). "Trans sodium crocetinate and diffusion enhancement". The Journal of Physical Chemistry B. 110 (37): 18078–18080. doi:10.1021/jp064308+. PMID 16970413.
  • Laidig, K.E.; J.L. Gainer; V. Daggett (1998). "Altering Diffusivity in Biological Solutions through Modification of Solution Structure and Dynamics". Journal of the American Chemical Society. 120 (36): 9394–9395. doi:10.1021/ja981656j.
  • Manabe H; et al. (2010). "Protection against focal ischemic injury to the brain by trans-sodium crocetinate". Journal of Neurosurgery. 113 (4): 802–809. doi:10.3171/2009.10.JNS09562. PMC 3380430. PMID 19961314.
  • Berger F, Hensel A, Nieber K (2011). "Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices". Neuroscience. 180: 238–47. doi:10.1016/j.neuroscience.2011.02.037. PMID 21352900. S2CID 23525322.
  • Lautenschläger M, Lechtenberg M, Sendker J, Hensel A (2014). "Effective isolation protocol for secondary metabolites from saffron: semi-preparative scale preparation of crocin-1 and trans-crocetin". Fitoterapia. 92: 290–5. doi:10.1016/j.fitote.2013.11.014. PMID 24321578.
  • Lautenschläger M, Sendker J, Hüwel S, Galla HJ, Brandt S, Düfer M, Riehemann K, Hensel A (2015). "Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier". Phytomedicine. 22 (1): 36–44. doi:10.1016/j.phymed.2014.10.009. PMID 25636868.

espacenet.com

worldwide.espacenet.com

  • US patent 8,206,751, Gainer J, "New Class of Therapeutics that Enhance Small Molecule Diffusion", issued 2009-04-30 
  • US patent 6,060,511, Gainer J, "Trans-sodium crocetinate, methods of making and methods of use thereof", issued 2000-05-09 

nih.gov

pubmed.ncbi.nlm.nih.gov

  • Umigai N, Murakami K, Ulit MV, et al. (May 2011). "The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration". Phytomedicine. 18 (7): 575–8. doi:10.1016/j.phymed.2010.10.019. PMID 21112749.
  • Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU, Jung WS, Cho KH, Park JH, Kang I, Hong JW, Lee EH (2010). "Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells". European Journal of Pharmacology. 648 (1–3): 110–6. doi:10.1016/j.ejphar.2010.09.003. PMID 20854811.
  • Mizuma H, Tanaka M, Nozaki S, Mizuno K, Tahara T, Ataka S, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y (March 2009). "Daily oral administration of crocetin attenuates physical fatigue in human subjects". Nutrition Research. 29 (3): 145–50. doi:10.1016/j.nutres.2009.02.003. PMID 19358927.
  • Kuratsune H, Umigai N, Takeno R, Kajimoto Y, Nakano T (September 2010). "Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study". Phytomedicine. 17 (11): 840–3. doi:10.1016/j.phymed.2010.03.025. PMID 20537515.
  • Yamauchi, M; Tsuruma, K; Imai, S; Nakanishi, T; Umigai, N; Shimazawa, M; Hara, H (2011). "Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity". European Journal of Pharmacology. 650 (1): 110–9. doi:10.1016/j.ejphar.2010.09.081. PMID 20951131.
  • Gainer, J (2008). "Trans-sodium crocetinate for treating hypoxia/ischemia". Expert Opinion on Investigational Drugs. 17 (6): 917–924. doi:10.1517/13543784.17.6.917. PMID 18491992. S2CID 71663644.
  • Giassi L; et al. (2001). "Trans-Sodium Crocetinate Restores Blood Pressure, Heart Rate, and Plasma Lactate after Hemorrhagic Shock". Journal of Trauma-Injury Infection & Critical Care. 51 (5): 932–938. doi:10.1097/00005373-200111000-00018. PMID 11706343.
  • Lapchak P (2010). "Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: A combination therapy study with tissue plasminogen activator". Brain Research. 1309: 136–145. doi:10.1016/j.brainres.2009.10.067. PMID 19891959. S2CID 25369069.
  • Mohler E; et al. (2010). "Evaluation of trans sodium crocetinate on safety and exercise performance in patients with peripheral artery disease and intermittent claudication". Vascular Medicine. 16 (5): 346–352. doi:10.1177/1358863X11422742. PMC 4182020. PMID 22003000.
  • Stennett a; et al. (2006). "Trans sodium crocetinate and diffusion enhancement". The Journal of Physical Chemistry B. 110 (37): 18078–18080. doi:10.1021/jp064308+. PMID 16970413.
  • Manabe H; et al. (2010). "Protection against focal ischemic injury to the brain by trans-sodium crocetinate". Journal of Neurosurgery. 113 (4): 802–809. doi:10.3171/2009.10.JNS09562. PMC 3380430. PMID 19961314.
  • Berger F, Hensel A, Nieber K (2011). "Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices". Neuroscience. 180: 238–47. doi:10.1016/j.neuroscience.2011.02.037. PMID 21352900. S2CID 23525322.
  • Lautenschläger M, Lechtenberg M, Sendker J, Hensel A (2014). "Effective isolation protocol for secondary metabolites from saffron: semi-preparative scale preparation of crocin-1 and trans-crocetin". Fitoterapia. 92: 290–5. doi:10.1016/j.fitote.2013.11.014. PMID 24321578.
  • Lautenschläger M, Sendker J, Hüwel S, Galla HJ, Brandt S, Düfer M, Riehemann K, Hensel A (2015). "Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier". Phytomedicine. 22 (1): 36–44. doi:10.1016/j.phymed.2014.10.009. PMID 25636868.

ncbi.nlm.nih.gov

pubchem.ncbi.nlm.nih.gov

semanticscholar.org

api.semanticscholar.org