DNA-PKcs (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "DNA-PKcs" in English language version.

refsWebsite

Global rank English rank

84nih.gov

4^th place

53doi.org

2^nd place

8harvard.edu

18^th place

17^th place

4semanticscholar.org

11^th place

8^th place

2ensembl.org

1,626^th place

1,007^th place

1web.archive.org

1^st place

1psu.edu

207^th place

136^th place

1aacrjournals.org

8,869^th place

8,487^th place

aacrjournals.org (Global: 8,869^th place; English: 8,487^th place)

Zenke FT, Zimmermann A, Sirrenberg C, Dahmen H, Kirkin V, Pehl U, et al. (2020). "Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models". Molecular Cancer Therapeutics. 19 (5): 1091–1101. doi:10.1158/1535-7163.MCT-19-0734. PMID 32220971.

doi.org (Global: 2^nd place; English: 2^nd place)

Kumar KR (2023). "Lost in the bloom: DNA-PKcs in green plants". Front Plant Sci. 14 1231678. Bibcode:2023FrPS...1431678K. doi:10.3389/fpls.2023.1231678. PMC 10419180. PMID 37575944.
Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW (August 1995). "Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7515–9. Bibcode:1995PNAS...92.7515S. doi:10.1073/pnas.92.16.7515. PMC 41370. PMID 7638222.
Sibanda BL, Chirgadze DY, Blundell TL (January 2010). "Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats". Nature. 463 (7277): 118–121. doi:10.1038/nature08648. PMC 2811870. PMID 20023628.
Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. (September 1995). "DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product". Cell. 82 (5): 849–856. doi:10.1016/0092-8674(95)90482-4. PMID 7671312.
Meek K, Dang V, Lees-Miller SP (2008). Chapter 2 DNA-PK. Advances in Immunology. Vol. 99. pp. 33–58. doi:10.1016/S0065-2776(08)00602-0. ISBN 978-0-12-374325-1. PMID 19117531.
Meek K, Jutkowitz A, Allen L, Glover J, Convery E, Massa A, et al. (August 2009). "SCID dogs: similar transplant potential but distinct intra-uterine growth defects and premature replicative senescence compared with SCID mice". Journal of Immunology. 183 (4): 2529–36. doi:10.4049/jimmunol.0801406. PMC 4047667. PMID 19635917.
Anne Esguerra Z, Watanabe G, Okitsu CY, Hsieh CL, Lieber MR (April 2020). "DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination". Molecular Immunology. 120: 93–100. doi:10.1016/j.molimm.2020.01.018. PMC 7184946. PMID 32113132.
Wang S, Guo M, Ouyang H, Li X, Cordon-Cardo C, Kurimasa A, et al. (February 2000). "The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest". Proc Natl Acad Sci U S A. 97 (4): 1584–8. Bibcode:2000PNAS...97.1584W. doi:10.1073/pnas.97.4.1584. PMC 26478. PMID 10677503.
Bernstein C, Bernstein H, Payne CM, Garewal H (June 2002). "DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis". Mutat Res. 511 (2): 145–78. Bibcode:2002MRRMR.511..145B. doi:10.1016/s1383-5742(02)00009-1. PMID 12052432.
Kastan MB (April 2008). "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture". Molecular Cancer Research. 6 (4): 517–524. doi:10.1158/1541-7786.MCR-08-0020. PMID 18403632.
Harper JW, Elledge SJ (December 2007). "The DNA damage response: ten years after". Molecular Cell. 28 (5): 739–745. doi:10.1016/j.molcel.2007.11.015. PMID 18082599.
Dietlein F, Reinhardt HC (December 2014). "Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy". Clinical Cancer Research. 20 (23): 5882–7. doi:10.1158/1078-0432.CCR-14-1165. PMID 25451105.
O'Hagan HM, Mohammad HP, Baylin SB (August 2008). "Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island". PLOS Genetics. 4 (8) e1000155. doi:10.1371/journal.pgen.1000155. PMC 2491723. PMID 18704159.
Cuozzo C, Porcellini A, Angrisano T, Morano A, Lee B, Di Pardo A, et al. (July 2007). "DNA damage, homology-directed repair, and DNA methylation". PLOS Genetics. 3 (7) e110. doi:10.1371/journal.pgen.0030110. PMC 1913100. PMID 17616978.
Er TK, Su YF, Wu CC, Chen CC, Wang J, Hsieh TH, et al. (July 2016). "Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer". Journal of Molecular Medicine. 94 (7): 835–847. doi:10.1007/s00109-016-1395-2. PMID 26920370. S2CID 16399834.
Wang X, Szabo C, Qian C, Amadio PG, Thibodeau SN, Cerhan JR, et al. (February 2008). "Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers". Cancer Research. 68 (4): 971–5. doi:10.1158/0008-5472.CAN-07-6272. PMID 18281469.
Söderlund Leifler K, Queseth S, Fornander T, Askmalm MS (December 2010). "Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer". International Journal of Oncology. 37 (6): 1547–54. doi:10.3892/ijo_00000808. PMID 21042724.
Bouchaert P, Guerif S, Debiais C, Irani J, Fromont G (December 2012). "DNA-PKcs expression predicts response to radiotherapy in prostate cancer". International Journal of Radiation Oncology, Biology, Physics. 84 (5): 1179–85. doi:10.1016/j.ijrobp.2012.02.014. PMID 22494583.
Lee SW, Cho KJ, Park JH, Kim SY, Nam SY, Lee BJ, et al. (August 2005). "Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma". International Journal of Radiation Oncology, Biology, Physics. 62 (5): 1451–7. doi:10.1016/j.ijrobp.2004.12.049. PMID 16029807.
Abdel-Fatah TM, Arora A, Moseley P, Coveney C, Perry C, Johnson K, et al. (December 2014). "ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers". BBA Clinical. 2: 10–17. doi:10.1016/j.bbacli.2014.08.001. PMC 4633921. PMID 26674120.
Lee HS, Yang HK, Kim WH, Choe G (April 2005). "Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers". Cancer Research and Treatment. 37 (2): 98–102. doi:10.4143/crt.2005.37.2.98. PMC 2785401. PMID 19956487.
Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, et al. (July 2010). "Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation". PLOS ONE. 5 (7) e11397. Bibcode:2010PLoSO...511397Y. doi:10.1371/journal.pone.0011397. PMC 2895662. PMID 20617180.
Li M, Tian L, Ren H, Chen X, Wang Y, Ge J, et al. (August 2015). "MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8". Journal of Translational Medicine. 13 271. doi:10.1186/s12967-015-0626-6. PMC 4545549. PMID 26286725.
Liu Z, Wang J, Mao Y, Zou B, Fan X (January 2016). "MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells". Oncology Letters. 11 (1): 433–8. doi:10.3892/ol.2015.3832. PMC 4727073. PMID 26870229.
Li AY, Boo LM, Wang SY, Lin HH, Wang CC, Yen Y, et al. (July 2009). "Suppression of nonhomologous end joining repair by overexpression of HMGA2". Cancer Research. 69 (14): 5699–5706. doi:10.1158/0008-5472.CAN-08-4833. PMC 2737594. PMID 19549901.
Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K, Mori M (April 2008). "Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family". Clinical Cancer Research. 14 (8): 2334–40. doi:10.1158/1078-0432.CCR-07-4667. PMID 18413822.
Wu A, Wu K, Li J, Mo Y, Lin Y, Wang Y, et al. (March 2015). "Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma". Journal of Translational Medicine. 13 105. doi:10.1186/s12967-015-0462-8. PMC 4391148. PMID 25884389.
Vrba L, Muñoz-Rodríguez JL, Stampfer MR, Futscher BW (2013). "miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer". PLOS ONE. 8 (1) e54398. Bibcode:2013PLoSO...854398V. doi:10.1371/journal.pone.0054398. PMC 3547033. PMID 23342147.
Lee HS, Choe G, Park KU, Park DJ, Yang HK, Lee BL, et al. (October 2007). "Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer". International Journal of Oncology. 31 (4): 859–866. doi:10.3892/ijo.31.4.859. PMID 17786318.
Shintani S, Mihara M, Li C, Nakahara Y, Hino S, Nakashiro K, et al. (October 2003). "Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma". Cancer Science. 94 (10): 894–900. doi:10.1111/j.1349-7006.2003.tb01372.x. PMC 11160163. PMID 14556663. S2CID 2126685.
Riabinska A, Daheim M, Herter-Sprie GS, Winkler J, Fritz C, Hallek M, et al. (June 2013). "Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors". Science Translational Medicine. 5 (189): 189ra78. doi:10.1126/scitranslmed.3005814. PMID 23761041. S2CID 206681916.
Hsu FM, Zhang S, Chen BP (June 2012). "Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment". Translational Cancer Research. 1 (1): 22–34. doi:10.3978/j.issn.2218-676X.2012.04.01. PMC 3431019. PMID 22943041.
Espejel S, Martín M, Klatt P, Martín-Caballero J, Flores JM, Blasco MA (May 2004). "Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice". EMBO Reports. 5 (5): 503–9. doi:10.1038/sj.embor.7400127. PMC 1299048. PMID 15105825.
Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, et al. (2014). "The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency". PLOS ONE. 9 (4) e93568. Bibcode:2014PLoSO...993568R. doi:10.1371/journal.pone.0093568. PMC 3989187. PMID 24740260.
Kim ST, Lim DS, Canman CE, Kastan MB (December 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". The Journal of Biological Chemistry. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Suzuki K, Kodama S, Watanabe M (September 1999). "Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation". The Journal of Biological Chemistry. 274 (36): 25571–5. doi:10.1074/jbc.274.36.25571. PMID 10464290.
Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP (July 1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes & Development. 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. PMC 317006. PMID 9679063.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y (August 2003). "Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex". The Journal of Biological Chemistry. 278 (32): 29940–7. doi:10.1074/jbc.M301765200. PMID 12756247.
Liu L, Kwak YT, Bex F, García-Martínez LF, Li XH, Meek K, et al. (July 1998). "DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties". Molecular and Cellular Biology. 18 (7): 4221–34. doi:10.1128/MCB.18.7.4221. PMC 109006. PMID 9632806.
Wu X, Lieber MR (October 1997). "Interaction between DNA-dependent protein kinase and a novel protein, KIP". Mutation Research. 385 (1): 13–20. doi:10.1016/s0921-8777(97)00035-9. PMID 9372844.
Ma Y, Pannicke U, Schwarz K, Lieber MR (March 2002). "Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination". Cell. 108 (6): 781–794. doi:10.1016/s0092-8674(02)00671-2. PMID 11955432.
Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. CiteSeerX 10.1.1.615.1747. doi:10.1074/jbc.273.4.2136. PMID 9442054. S2CID 8781571.
Jin S, Kharbanda S, Mayer B, Kufe D, Weaver DT (October 1997). "Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit". The Journal of Biological Chemistry. 272 (40): 24763–6. doi:10.1074/jbc.272.40.24763. PMID 9312071.
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1578 (1–3): 59–72. doi:10.1016/s0167-4781(02)00497-9. PMID 12393188.
Gell D, Jackson SP (September 1999). "Mapping of protein-protein interactions within the DNA-dependent protein kinase complex". Nucleic Acids Research. 27 (17): 3494–3502. doi:10.1093/nar/27.17.3494. PMC 148593. PMID 10446239.
Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proceedings of the National Academy of Sciences of the United States of America. 97 (11): 6212–7. Bibcode:2000PNAS...97.6212K. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.
Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y (March 1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes". The EMBO Journal. 18 (5): 1397–1406. doi:10.1093/emboj/18.5.1397. PMC 1171229. PMID 10064605.
Karmakar P, Piotrowski J, Brosh RM, Sommers JA, Miller SP, Cheng WH, et al. (May 2002). "Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation". The Journal of Biological Chemistry. 277 (21): 18291–302. doi:10.1074/jbc.M111523200. PMID 11889123.
Goldberg FW, Finlay MR, Ting AK, Beattie D, Lamont GM, Fallan C, et al. (April 2020). "The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor". Journal of Medicinal Chemistry. 63 (7): 3461–3471. doi:10.1021/acs.jmedchem.9b01684. PMID 31851518.
Zenke FT, Zimmermann A, Sirrenberg C, Dahmen H, Kirkin V, Pehl U, et al. (2020). "Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models". Molecular Cancer Therapeutics. 19 (5): 1091–1101. doi:10.1158/1535-7163.MCT-19-0734. PMID 32220971.
Khan AJ, Misenko SM, Thandoni A, Schiff D, Jhawar SR, Bunting SF, et al. (May 2018). "VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells". Oncotarget. 9 (40): 25833–25841. doi:10.18632/oncotarget.25383. PMC 5995231. PMID 29899825.
Berger M, Wortmann L, Buchgraber P, Lücking U, Zitzmann-Kolbe S, Wengner AM, et al. (September 2021). "BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies". Journal of Medicinal Chemistry. 64 (17): 12723–12737. doi:10.1021/acs.jmedchem.1c00762. PMID 34428039.

ensembl.org (Global: 1,626^th place; English: 1,007^th place)

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000253729 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022672 – Ensembl, May 2017

harvard.edu (Global: 18^th place; English: 17^th place)

ui.adsabs.harvard.edu

Kumar KR (2023). "Lost in the bloom: DNA-PKcs in green plants". Front Plant Sci. 14 1231678. Bibcode:2023FrPS...1431678K. doi:10.3389/fpls.2023.1231678. PMC 10419180. PMID 37575944.
Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW (August 1995). "Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7515–9. Bibcode:1995PNAS...92.7515S. doi:10.1073/pnas.92.16.7515. PMC 41370. PMID 7638222.
Wang S, Guo M, Ouyang H, Li X, Cordon-Cardo C, Kurimasa A, et al. (February 2000). "The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest". Proc Natl Acad Sci U S A. 97 (4): 1584–8. Bibcode:2000PNAS...97.1584W. doi:10.1073/pnas.97.4.1584. PMC 26478. PMID 10677503.
Bernstein C, Bernstein H, Payne CM, Garewal H (June 2002). "DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis". Mutat Res. 511 (2): 145–78. Bibcode:2002MRRMR.511..145B. doi:10.1016/s1383-5742(02)00009-1. PMID 12052432.
Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, et al. (July 2010). "Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation". PLOS ONE. 5 (7) e11397. Bibcode:2010PLoSO...511397Y. doi:10.1371/journal.pone.0011397. PMC 2895662. PMID 20617180.
Vrba L, Muñoz-Rodríguez JL, Stampfer MR, Futscher BW (2013). "miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer". PLOS ONE. 8 (1) e54398. Bibcode:2013PLoSO...854398V. doi:10.1371/journal.pone.0054398. PMC 3547033. PMID 23342147.
Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, et al. (2014). "The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency". PLOS ONE. 9 (4) e93568. Bibcode:2014PLoSO...993568R. doi:10.1371/journal.pone.0093568. PMC 3989187. PMID 24740260.
Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proceedings of the National Academy of Sciences of the United States of America. 97 (11): 6212–7. Bibcode:2000PNAS...97.6212K. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Kumar KR (2023). "Lost in the bloom: DNA-PKcs in green plants". Front Plant Sci. 14 1231678. Bibcode:2023FrPS...1431678K. doi:10.3389/fpls.2023.1231678. PMC 10419180. PMID 37575944.
Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW (August 1995). "Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8". Proceedings of the National Academy of Sciences of the United States of America. 92 (16): 7515–9. Bibcode:1995PNAS...92.7515S. doi:10.1073/pnas.92.16.7515. PMC 41370. PMID 7638222.
Sibanda BL, Chirgadze DY, Blundell TL (January 2010). "Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats". Nature. 463 (7277): 118–121. doi:10.1038/nature08648. PMC 2811870. PMID 20023628.
Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al. (September 1995). "DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product". Cell. 82 (5): 849–856. doi:10.1016/0092-8674(95)90482-4. PMID 7671312.
Meek K, Dang V, Lees-Miller SP (2008). Chapter 2 DNA-PK. Advances in Immunology. Vol. 99. pp. 33–58. doi:10.1016/S0065-2776(08)00602-0. ISBN 978-0-12-374325-1. PMID 19117531.
Meek K, Jutkowitz A, Allen L, Glover J, Convery E, Massa A, et al. (August 2009). "SCID dogs: similar transplant potential but distinct intra-uterine growth defects and premature replicative senescence compared with SCID mice". Journal of Immunology. 183 (4): 2529–36. doi:10.4049/jimmunol.0801406. PMC 4047667. PMID 19635917.
Anne Esguerra Z, Watanabe G, Okitsu CY, Hsieh CL, Lieber MR (April 2020). "DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination". Molecular Immunology. 120: 93–100. doi:10.1016/j.molimm.2020.01.018. PMC 7184946. PMID 32113132.
Wang S, Guo M, Ouyang H, Li X, Cordon-Cardo C, Kurimasa A, et al. (February 2000). "The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest". Proc Natl Acad Sci U S A. 97 (4): 1584–8. Bibcode:2000PNAS...97.1584W. doi:10.1073/pnas.97.4.1584. PMC 26478. PMID 10677503.
Bernstein C, Bernstein H, Payne CM, Garewal H (June 2002). "DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis". Mutat Res. 511 (2): 145–78. Bibcode:2002MRRMR.511..145B. doi:10.1016/s1383-5742(02)00009-1. PMID 12052432.
Kastan MB (April 2008). "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture". Molecular Cancer Research. 6 (4): 517–524. doi:10.1158/1541-7786.MCR-08-0020. PMID 18403632.
Harper JW, Elledge SJ (December 2007). "The DNA damage response: ten years after". Molecular Cell. 28 (5): 739–745. doi:10.1016/j.molcel.2007.11.015. PMID 18082599.
Dietlein F, Reinhardt HC (December 2014). "Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy". Clinical Cancer Research. 20 (23): 5882–7. doi:10.1158/1078-0432.CCR-14-1165. PMID 25451105.
O'Hagan HM, Mohammad HP, Baylin SB (August 2008). "Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island". PLOS Genetics. 4 (8) e1000155. doi:10.1371/journal.pgen.1000155. PMC 2491723. PMID 18704159.
Cuozzo C, Porcellini A, Angrisano T, Morano A, Lee B, Di Pardo A, et al. (July 2007). "DNA damage, homology-directed repair, and DNA methylation". PLOS Genetics. 3 (7) e110. doi:10.1371/journal.pgen.0030110. PMC 1913100. PMID 17616978.
Er TK, Su YF, Wu CC, Chen CC, Wang J, Hsieh TH, et al. (July 2016). "Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer". Journal of Molecular Medicine. 94 (7): 835–847. doi:10.1007/s00109-016-1395-2. PMID 26920370. S2CID 16399834.
Wang X, Szabo C, Qian C, Amadio PG, Thibodeau SN, Cerhan JR, et al. (February 2008). "Mutational analysis of thirty-two double-strand DNA break repair genes in breast and pancreatic cancers". Cancer Research. 68 (4): 971–5. doi:10.1158/0008-5472.CAN-07-6272. PMID 18281469.
Söderlund Leifler K, Queseth S, Fornander T, Askmalm MS (December 2010). "Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer". International Journal of Oncology. 37 (6): 1547–54. doi:10.3892/ijo_00000808. PMID 21042724.
Bouchaert P, Guerif S, Debiais C, Irani J, Fromont G (December 2012). "DNA-PKcs expression predicts response to radiotherapy in prostate cancer". International Journal of Radiation Oncology, Biology, Physics. 84 (5): 1179–85. doi:10.1016/j.ijrobp.2012.02.014. PMID 22494583.
Zhuang L, Yu SY, Huang XY, Cao Y, Xiong HH (July 2007). "[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells]". AI Zheng = Aizheng = Chinese Journal of Cancer (in Chinese). 26 (7): 724–9. PMID 17626748.
Lee SW, Cho KJ, Park JH, Kim SY, Nam SY, Lee BJ, et al. (August 2005). "Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma". International Journal of Radiation Oncology, Biology, Physics. 62 (5): 1451–7. doi:10.1016/j.ijrobp.2004.12.049. PMID 16029807.
Abdel-Fatah TM, Arora A, Moseley P, Coveney C, Perry C, Johnson K, et al. (December 2014). "ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers". BBA Clinical. 2: 10–17. doi:10.1016/j.bbacli.2014.08.001. PMC 4633921. PMID 26674120.
Lee HS, Yang HK, Kim WH, Choe G (April 2005). "Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers". Cancer Research and Treatment. 37 (2): 98–102. doi:10.4143/crt.2005.37.2.98. PMC 2785401. PMID 19956487.
Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, et al. (July 2010). "Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation". PLOS ONE. 5 (7) e11397. Bibcode:2010PLoSO...511397Y. doi:10.1371/journal.pone.0011397. PMC 2895662. PMID 20617180.
Li M, Tian L, Ren H, Chen X, Wang Y, Ge J, et al. (August 2015). "MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8". Journal of Translational Medicine. 13 271. doi:10.1186/s12967-015-0626-6. PMC 4545549. PMID 26286725.
Liu Z, Wang J, Mao Y, Zou B, Fan X (January 2016). "MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells". Oncology Letters. 11 (1): 433–8. doi:10.3892/ol.2015.3832. PMC 4727073. PMID 26870229.
Li AY, Boo LM, Wang SY, Lin HH, Wang CC, Yen Y, et al. (July 2009). "Suppression of nonhomologous end joining repair by overexpression of HMGA2". Cancer Research. 69 (14): 5699–5706. doi:10.1158/0008-5472.CAN-08-4833. PMC 2737594. PMID 19549901.
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Wu A, Wu K, Li J, Mo Y, Lin Y, Wang Y, et al. (March 2015). "Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma". Journal of Translational Medicine. 13 105. doi:10.1186/s12967-015-0462-8. PMC 4391148. PMID 25884389.
Vrba L, Muñoz-Rodríguez JL, Stampfer MR, Futscher BW (2013). "miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer". PLOS ONE. 8 (1) e54398. Bibcode:2013PLoSO...854398V. doi:10.1371/journal.pone.0054398. PMC 3547033. PMID 23342147.
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Shintani S, Mihara M, Li C, Nakahara Y, Hino S, Nakashiro K, et al. (October 2003). "Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma". Cancer Science. 94 (10): 894–900. doi:10.1111/j.1349-7006.2003.tb01372.x. PMC 11160163. PMID 14556663. S2CID 2126685.
Riabinska A, Daheim M, Herter-Sprie GS, Winkler J, Fritz C, Hallek M, et al. (June 2013). "Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors". Science Translational Medicine. 5 (189): 189ra78. doi:10.1126/scitranslmed.3005814. PMID 23761041. S2CID 206681916.
Hsu FM, Zhang S, Chen BP (June 2012). "Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment". Translational Cancer Research. 1 (1): 22–34. doi:10.3978/j.issn.2218-676X.2012.04.01. PMC 3431019. PMID 22943041.
Espejel S, Martín M, Klatt P, Martín-Caballero J, Flores JM, Blasco MA (May 2004). "Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice". EMBO Reports. 5 (5): 503–9. doi:10.1038/sj.embor.7400127. PMC 1299048. PMID 15105825.
Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, et al. (2014). "The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency". PLOS ONE. 9 (4) e93568. Bibcode:2014PLoSO...993568R. doi:10.1371/journal.pone.0093568. PMC 3989187. PMID 24740260.
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Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
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Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. CiteSeerX 10.1.1.615.1747. doi:10.1074/jbc.273.4.2136. PMID 9442054. S2CID 8781571.
Jin S, Kharbanda S, Mayer B, Kufe D, Weaver DT (October 1997). "Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit". The Journal of Biological Chemistry. 272 (40): 24763–6. doi:10.1074/jbc.272.40.24763. PMID 9312071.
Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (October 2002). "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1578 (1–3): 59–72. doi:10.1016/s0167-4781(02)00497-9. PMID 12393188.
Gell D, Jackson SP (September 1999). "Mapping of protein-protein interactions within the DNA-dependent protein kinase complex". Nucleic Acids Research. 27 (17): 3494–3502. doi:10.1093/nar/27.17.3494. PMC 148593. PMID 10446239.
Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proceedings of the National Academy of Sciences of the United States of America. 97 (11): 6212–7. Bibcode:2000PNAS...97.6212K. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.
Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y (March 1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes". The EMBO Journal. 18 (5): 1397–1406. doi:10.1093/emboj/18.5.1397. PMC 1171229. PMID 10064605.
Karmakar P, Piotrowski J, Brosh RM, Sommers JA, Miller SP, Cheng WH, et al. (May 2002). "Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation". The Journal of Biological Chemistry. 277 (21): 18291–302. doi:10.1074/jbc.M111523200. PMID 11889123.
Goldberg FW, Finlay MR, Ting AK, Beattie D, Lamont GM, Fallan C, et al. (April 2020). "The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor". Journal of Medicinal Chemistry. 63 (7): 3461–3471. doi:10.1021/acs.jmedchem.9b01684. PMID 31851518.
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ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Lee HS, Yang HK, Kim WH, Choe G (April 2005). "Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in gastric cancers". Cancer Research and Treatment. 37 (2): 98–102. doi:10.4143/crt.2005.37.2.98. PMC 2785401. PMID 19956487.
Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, et al. (July 2010). "Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation". PLOS ONE. 5 (7) e11397. Bibcode:2010PLoSO...511397Y. doi:10.1371/journal.pone.0011397. PMC 2895662. PMID 20617180.
Li M, Tian L, Ren H, Chen X, Wang Y, Ge J, et al. (August 2015). "MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8". Journal of Translational Medicine. 13 271. doi:10.1186/s12967-015-0626-6. PMC 4545549. PMID 26286725.
Liu Z, Wang J, Mao Y, Zou B, Fan X (January 2016). "MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells". Oncology Letters. 11 (1): 433–8. doi:10.3892/ol.2015.3832. PMC 4727073. PMID 26870229.
Li AY, Boo LM, Wang SY, Lin HH, Wang CC, Yen Y, et al. (July 2009). "Suppression of nonhomologous end joining repair by overexpression of HMGA2". Cancer Research. 69 (14): 5699–5706. doi:10.1158/0008-5472.CAN-08-4833. PMC 2737594. PMID 19549901.
Wu A, Wu K, Li J, Mo Y, Lin Y, Wang Y, et al. (March 2015). "Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma". Journal of Translational Medicine. 13 105. doi:10.1186/s12967-015-0462-8. PMC 4391148. PMID 25884389.
Vrba L, Muñoz-Rodríguez JL, Stampfer MR, Futscher BW (2013). "miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer". PLOS ONE. 8 (1) e54398. Bibcode:2013PLoSO...854398V. doi:10.1371/journal.pone.0054398. PMC 3547033. PMID 23342147.
Shintani S, Mihara M, Li C, Nakahara Y, Hino S, Nakashiro K, et al. (October 2003). "Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma". Cancer Science. 94 (10): 894–900. doi:10.1111/j.1349-7006.2003.tb01372.x. PMC 11160163. PMID 14556663. S2CID 2126685.
Hsu FM, Zhang S, Chen BP (June 2012). "Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment". Translational Cancer Research. 1 (1): 22–34. doi:10.3978/j.issn.2218-676X.2012.04.01. PMC 3431019. PMID 22943041.
Espejel S, Martín M, Klatt P, Martín-Caballero J, Flores JM, Blasco MA (May 2004). "Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice". EMBO Reports. 5 (5): 503–9. doi:10.1038/sj.embor.7400127. PMC 1299048. PMID 15105825.
Reiling E, Dollé ME, Youssef SA, Lee M, Nagarajah B, Roodbergen M, et al. (2014). "The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency". PLOS ONE. 9 (4) e93568. Bibcode:2014PLoSO...993568R. doi:10.1371/journal.pone.0093568. PMC 3989187. PMID 24740260.
Yavuzer U, Smith GC, Bliss T, Werner D, Jackson SP (July 1998). "DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D". Genes & Development. 12 (14): 2188–99. doi:10.1101/gad.12.14.2188. PMC 317006. PMID 9679063.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Liu L, Kwak YT, Bex F, García-Martínez LF, Li XH, Meek K, et al. (July 1998). "DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties". Molecular and Cellular Biology. 18 (7): 4221–34. doi:10.1128/MCB.18.7.4221. PMC 109006. PMID 9632806.
Gell D, Jackson SP (September 1999). "Mapping of protein-protein interactions within the DNA-dependent protein kinase complex". Nucleic Acids Research. 27 (17): 3494–3502. doi:10.1093/nar/27.17.3494. PMC 148593. PMID 10446239.
Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator". Proceedings of the National Academy of Sciences of the United States of America. 97 (11): 6212–7. Bibcode:2000PNAS...97.6212K. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.
Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y (March 1999). "Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes". The EMBO Journal. 18 (5): 1397–1406. doi:10.1093/emboj/18.5.1397. PMC 1171229. PMID 10064605.
Khan AJ, Misenko SM, Thandoni A, Schiff D, Jhawar SR, Bunting SF, et al. (May 2018). "VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells". Oncotarget. 9 (40): 25833–25841. doi:10.18632/oncotarget.25383. PMC 5995231. PMID 29899825.

psu.edu (Global: 207^th place; English: 136^th place)

citeseerx.ist.psu.edu

Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. CiteSeerX 10.1.1.615.1747. doi:10.1074/jbc.273.4.2136. PMID 9442054. S2CID 8781571.

semanticscholar.org (Global: 11^th place; English: 8^th place)

api.semanticscholar.org

Er TK, Su YF, Wu CC, Chen CC, Wang J, Hsieh TH, et al. (July 2016). "Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer". Journal of Molecular Medicine. 94 (7): 835–847. doi:10.1007/s00109-016-1395-2. PMID 26920370. S2CID 16399834.
Shintani S, Mihara M, Li C, Nakahara Y, Hino S, Nakashiro K, et al. (October 2003). "Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma". Cancer Science. 94 (10): 894–900. doi:10.1111/j.1349-7006.2003.tb01372.x. PMC 11160163. PMID 14556663. S2CID 2126685.
Riabinska A, Daheim M, Herter-Sprie GS, Winkler J, Fritz C, Hallek M, et al. (June 2013). "Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors". Science Translational Medicine. 5 (189): 189ra78. doi:10.1126/scitranslmed.3005814. PMID 23761041. S2CID 206681916.
Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. CiteSeerX 10.1.1.615.1747. doi:10.1074/jbc.273.4.2136. PMID 9442054. S2CID 8781571.

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Bernstein H, Payne CM, Bernstein C, Garewal H, Dvorak K (2008). "1. Cancer and aging as consequences of un-repaired DNA damage". In Kimura H, Suzuki A (eds.). New Research on DNA Damages. Nova Science. pp. 1–47. ISBN 978-1-60456-581-2. Archived from the original on 2014-10-25. Retrieved 2019-07-14.{{cite book}}: CS1 maint: bot: original URL status unknown (link)

DNA-PKcs (English Wikipedia)

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