Desmetramadol (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Desmetramadol" in English language version.

refsWebsite

Global rank English rank

21nih.gov

4^th place

13doi.org

2^nd place

2semanticscholar.org

11^th place

8^th place

1pharmgkb.org

low place

1legislation.gov.uk

809^th place

536^th place

doi.org

Sevcik J, Nieber K, Driessen B, Illes P (September 1993). "Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones". British Journal of Pharmacology. 110 (1): 169–76. doi:10.1111/j.1476-5381.1993.tb13788.x. PMC 2175982. PMID 8220877.
Borlak J, Hermann R, Erb K, Thum T (November 2003). "A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol". Metabolism. 52 (11): 1439–43. doi:10.1016/s0026-0495(03)00256-7. PMID 14624403.
Zebala JA, Schuler AD, Kahn SJ, Maeda DY (2019). "Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist". Frontiers in Pharmacology. 10: 1680. doi:10.3389/fphar.2019.01680. PMC 7025522. PMID 32116679.
Potschka H, Friderichs E, Löscher W (September 2000). "Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy". British Journal of Pharmacology. 131 (2): 203–12. doi:10.1038/sj.bjp.0703562. PMC 1572317. PMID 10991912.
Bamigbade TA, Davidson C, Langford RM, Stamford JA (September 1997). "Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus". British Journal of Anaesthesia. 79 (3): 352–6. doi:10.1093/bja/79.3.352. PMID 9389855.
Driessen B, Reimann W, Giertz H (March 1993). "Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro". British Journal of Pharmacology. 108 (3): 806–11. doi:10.1111/j.1476-5381.1993.tb12882.x. PMC 1908052. PMID 8467366.
Horishita T, Minami K, Uezono Y, Shiraishi M, Ogata J, Okamoto T, Shigematsu A (2006). "The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes". Pharmacology. 77 (2): 93–9. doi:10.1159/000093179. PMID 16679816. S2CID 23775035.
Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (July 2007). "Serotonin 5-HT(2C) receptors regulate anxiety-like behavior". Genes, Brain and Behavior. 6 (5): 491–6. doi:10.1111/j.1601-183X.2007.00316.x. PMID 17451451. S2CID 143950479.
Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, et al. (May 2001). "RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy". Neuropsychopharmacology. 24 (5): 478–91. doi:10.1016/S0893-133X(00)00223-2. PMID 11282248.
Eser D, Baghai TC, Möller HJ (June 2010). "Agomelatine: The evidence for its place in the treatment of depression". Core Evidence. 4: 171–9. doi:10.2147/CE.S6005. PMC 2899775. PMID 20694073.
Arndt T, Claussen U, Güssregen B, Schröfel S, Stürzer B, Werle A, Wolf G (May 2011). "Kratom alkaloids and O-desmethyltramadol in urine of a "Krypton" herbal mixture consumer". Forensic Science International. 208 (1–3): 47–52. doi:10.1016/j.forsciint.2010.10.025. PMID 21112167.
Kronstrand R, Roman M, Thelander G, Eriksson A (May 2011). "Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton". Journal of Analytical Toxicology. 35 (4): 242–7. doi:10.1093/anatox/35.4.242. PMID 21513619.
Zebala JA, Searle SL, Webster LR, Johnson MS, Schuler AD, Maeda DY, Kahn SJ (October 2019). "Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials". The Journal of Pain. 20 (10): 1218–1235. doi:10.1016/j.jpain.2019.04.005. PMC 6790288. PMID 31005596.

legislation.gov.uk

"The Misuse of Drugs (Designation) (Amendment) (England, Wales and Scotland) Order 2013". UK Home Office. 31 January 2013.

nih.gov

pubmed.ncbi.nlm.nih.gov

Sevcik J, Nieber K, Driessen B, Illes P (September 1993). "Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones". British Journal of Pharmacology. 110 (1): 169–76. doi:10.1111/j.1476-5381.1993.tb13788.x. PMC 2175982. PMID 8220877.
Borlak J, Hermann R, Erb K, Thum T (November 2003). "A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol". Metabolism. 52 (11): 1439–43. doi:10.1016/s0026-0495(03)00256-7. PMID 14624403.
Zebala JA, Schuler AD, Kahn SJ, Maeda DY (2019). "Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist". Frontiers in Pharmacology. 10: 1680. doi:10.3389/fphar.2019.01680. PMC 7025522. PMID 32116679.
Potschka H, Friderichs E, Löscher W (September 2000). "Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy". British Journal of Pharmacology. 131 (2): 203–12. doi:10.1038/sj.bjp.0703562. PMC 1572317. PMID 10991912.
Garrido MJ, Valle M, Campanero MA, Calvo R, Trocóniz IF (October 2000). "Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats". The Journal of Pharmacology and Experimental Therapeutics. 295 (1): 352–9. PMID 10992001.
Bamigbade TA, Davidson C, Langford RM, Stamford JA (September 1997). "Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus". British Journal of Anaesthesia. 79 (3): 352–6. doi:10.1093/bja/79.3.352. PMID 9389855.
Driessen B, Reimann W, Giertz H (March 1993). "Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro". British Journal of Pharmacology. 108 (3): 806–11. doi:10.1111/j.1476-5381.1993.tb12882.x. PMC 1908052. PMID 8467366.
Horishita T, Minami K, Uezono Y, Shiraishi M, Ogata J, Okamoto T, Shigematsu A (2006). "The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes". Pharmacology. 77 (2): 93–9. doi:10.1159/000093179. PMID 16679816. S2CID 23775035.
Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (July 2007). "Serotonin 5-HT(2C) receptors regulate anxiety-like behavior". Genes, Brain and Behavior. 6 (5): 491–6. doi:10.1111/j.1601-183X.2007.00316.x. PMID 17451451. S2CID 143950479.
Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, et al. (May 2001). "RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy". Neuropsychopharmacology. 24 (5): 478–91. doi:10.1016/S0893-133X(00)00223-2. PMID 11282248.
Eser D, Baghai TC, Möller HJ (June 2010). "Agomelatine: The evidence for its place in the treatment of depression". Core Evidence. 4: 171–9. doi:10.2147/CE.S6005. PMC 2899775. PMID 20694073.
Arndt T, Claussen U, Güssregen B, Schröfel S, Stürzer B, Werle A, Wolf G (May 2011). "Kratom alkaloids and O-desmethyltramadol in urine of a "Krypton" herbal mixture consumer". Forensic Science International. 208 (1–3): 47–52. doi:10.1016/j.forsciint.2010.10.025. PMID 21112167.
Bäckstrom BG, Classon G, Löwenhielm P, Thelander G (2010). "[Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden]". Läkartidningen. 107 (50): 3196–7. PMID 21294331.
Kronstrand R, Roman M, Thelander G, Eriksson A (May 2011). "Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton". Journal of Analytical Toxicology. 35 (4): 242–7. doi:10.1093/anatox/35.4.242. PMID 21513619.
Zebala JA, Searle SL, Webster LR, Johnson MS, Schuler AD, Maeda DY, Kahn SJ (October 2019). "Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials". The Journal of Pain. 20 (10): 1218–1235. doi:10.1016/j.jpain.2019.04.005. PMC 6790288. PMID 31005596.

ncbi.nlm.nih.gov

Sevcik J, Nieber K, Driessen B, Illes P (September 1993). "Effects of the central analgesic tramadol and its main metabolite, O-desmethyltramadol, on rat locus coeruleus neurones". British Journal of Pharmacology. 110 (1): 169–76. doi:10.1111/j.1476-5381.1993.tb13788.x. PMC 2175982. PMID 8220877.
Zebala JA, Schuler AD, Kahn SJ, Maeda DY (2019). "Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist". Frontiers in Pharmacology. 10: 1680. doi:10.3389/fphar.2019.01680. PMC 7025522. PMID 32116679.
Potschka H, Friderichs E, Löscher W (September 2000). "Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy". British Journal of Pharmacology. 131 (2): 203–12. doi:10.1038/sj.bjp.0703562. PMC 1572317. PMID 10991912.
Driessen B, Reimann W, Giertz H (March 1993). "Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro". British Journal of Pharmacology. 108 (3): 806–11. doi:10.1111/j.1476-5381.1993.tb12882.x. PMC 1908052. PMID 8467366.
Eser D, Baghai TC, Möller HJ (June 2010). "Agomelatine: The evidence for its place in the treatment of depression". Core Evidence. 4: 171–9. doi:10.2147/CE.S6005. PMC 2899775. PMID 20694073.
Zebala JA, Searle SL, Webster LR, Johnson MS, Schuler AD, Maeda DY, Kahn SJ (October 2019). "Desmetramadol Has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials". The Journal of Pain. 20 (10): 1218–1235. doi:10.1016/j.jpain.2019.04.005. PMC 6790288. PMID 31005596.

pharmgkb.org

Tramadol Pharmacokinetics, PharmGKB

semanticscholar.org

api.semanticscholar.org

Horishita T, Minami K, Uezono Y, Shiraishi M, Ogata J, Okamoto T, Shigematsu A (2006). "The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes". Pharmacology. 77 (2): 93–9. doi:10.1159/000093179. PMID 16679816. S2CID 23775035.
Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (July 2007). "Serotonin 5-HT(2C) receptors regulate anxiety-like behavior". Genes, Brain and Behavior. 6 (5): 491–6. doi:10.1111/j.1601-183X.2007.00316.x. PMID 17451451. S2CID 143950479.