Analysis of information sources in references of the Wikipedia article "DiPT" in English language version.
22.2.3.2 DiPT A member of the tryptamine chemical family, diisopropyltryptamine (DiPT) is a fascinating substance because, unlike most hallucinogens, its effects are predominantly auditory. It is also possibly less sensitive than other hallucinogens to the mindset of the user, the setting in which it is ingested, and other psychological considerations, perhaps because the auditory system has become less salient to the human organism as we have evolved into a vision-based species. In general, auditory pitch is perceived as lower than normal, and harmonious sounds lose their resonance with one another. This dissonance is even perceived by people with perfect pitch, which has some implications about where in the processing stream DiPT's effects occur. Voices are also altered and disharmonious with one another (Shulgin and Shulgin 1997 ) . DiPT has few other known effects; it would seem to call for further investigation from those interested in the neurology of sound, music, and verbal language processing. For example, it would be fascinating to know the effects of this substance on perceptions of tonal languages such as Chinese, Huichol, or Dogon; would it alter the words perceived as being spoken?
DiPT bound with moderate affinity to the 5-HT2C receptor (Ki= 290 ± 110 nM; Hill coefficient = −0.72 ± 0.05) and was a full agonist in the IP-1 formation assay (EC50 = 2380 ± 340 nM), producing 107.4 ± 2.5% of the maximal 5-HT effect.
[5-MeO-DMT] has been shown to be a centrally active drug in animal studies (Gessner and Page, 1962; Gallagher et al., 1964) and to be active parenterally in man. Like [DMT], it is not active orally, although the N,N-diisopropyl homolog [(DiPT)], as with the hindered dialkyl tryptamines mentioned earlier, is effective by the oral route (A. T. Shulgin, unpublished data, 1974). [...] With this in mind, three comments should be made. It is "knowledge" within the anonymous underground drug publications that not only is the [DPT] homolog mentioned above active orally but also that the diisopropyl counterpart [(DiPT)] is especially so.
A large body of anecdotal experiences supports the existence of differences in the subjective effects of serotonergic psychedelics, in particular concerning those elicited by relatively novel synthetic derivatives of phenethylamines (i.e., mescaline analogs) and tryptamines (i.e., DMT analogs). A frequently cited example is that of N,N-Diisopropyltryptamine (DiPT), a substituted tryptamine and 5-HT1A/2A agonist remarkable for producing auditory distortions, in contrast to the predominantly visual effects of classic psychedelics (Shulgin and Carter, 1979; Shulgin and Shulgin, 1997; Kometer and Vollenweider, 2016). [...] • DiPT (N,N-Diisopropyltryptamine): substituted tryptamine, first synthesized and tested by Shulgin and Carter (1979). [...] A total of 16 reports were obtained for mescaline, 143 for 2C-B, 206 for 2C-E, 101 for 2C-T-2, 36 for DOB, 32 for DOI, 23 for DOM, 19 for TMA-2, 63 for MDA, 770 for MDMA, 236 for DMT, 247 for 5-MeO-DMT, 69 for 5-MeO-MiPT, 45 for DiPT, 182 for 5-MeO-DiPT, 137 for DPT, 718 for LSD, 32 for ibogaine, 64 for 2C-C, 383 for 2C-I, 57 for 2C-P, 16 for 2C-T-4, 171 for 2C-T-7, 48 for 2C-D, 144 for 25I-NBOMe, 51 for 4-OH-MET, 109 for 5-MeO-AMT, 208 for 4-OH-DiPT and 8 for psilocin/psilocybin.
Auditory hallucinations can sometimes be triggered by the use of—or withdrawal from—illicit substances such as alcohol, cannabis, amphetamines, cocaine, [LSD], and [DMT]. Generally speaking, hallucinogens are more likely to induce visual than auditory misperceptions. If auditory misperceptions occur at all, they tend to do so in the context of compound hallucinations. A notable exception is diisopropyltryptamine (DiPT), a hallucinogenic of the tryptamine family, which primarily affects auditory pitch.
Other unsubstituted simple synthetic tryptamines are N,N-diallyltryptamine (DALT), diethyltryptamine (DET), di-isopropyltryptamine (DiPT) and dipropyltryptamine (DPT) (see Fig. 5). Each is active after ingestion, with serotonin-mediated visual hallucinations the main clinical effect. DiPT is unusual in that it produces primarily auditory hallucinations, with tinnitus as a side effect. 154
[5-MeO-DMT] has been shown to be a centrally active drug in animal studies (Gessner and Page, 1962; Gallagher et al., 1964) and to be active parenterally in man. Like [DMT], it is not active orally, although the N,N-diisopropyl homolog [(DiPT)], as with the hindered dialkyl tryptamines mentioned earlier, is effective by the oral route (A. T. Shulgin, unpublished data, 1974). [...] With this in mind, three comments should be made. It is "knowledge" within the anonymous underground drug publications that not only is the [DPT] homolog mentioned above active orally but also that the diisopropyl counterpart [(DiPT)] is especially so.
Sensory amplification: A deceptively simple tryptamine DIPT (N,N-diisopr()pyltryptamine) has been reported to amplify and distort the auditory sensory input signals (2) in preference to the more frequently seen visual distortions. This modality is closer to the usual symptomology of endogenous schizophrenia, and may well serve as a discriminating tool for differential research.
DiPT bound with moderate affinity to the 5-HT2C receptor (Ki= 290 ± 110 nM; Hill coefficient = −0.72 ± 0.05) and was a full agonist in the IP-1 formation assay (EC50 = 2380 ± 340 nM), producing 107.4 ± 2.5% of the maximal 5-HT effect.
A large body of anecdotal experiences supports the existence of differences in the subjective effects of serotonergic psychedelics, in particular concerning those elicited by relatively novel synthetic derivatives of phenethylamines (i.e., mescaline analogs) and tryptamines (i.e., DMT analogs). A frequently cited example is that of N,N-Diisopropyltryptamine (DiPT), a substituted tryptamine and 5-HT1A/2A agonist remarkable for producing auditory distortions, in contrast to the predominantly visual effects of classic psychedelics (Shulgin and Carter, 1979; Shulgin and Shulgin, 1997; Kometer and Vollenweider, 2016). [...] • DiPT (N,N-Diisopropyltryptamine): substituted tryptamine, first synthesized and tested by Shulgin and Carter (1979). [...] A total of 16 reports were obtained for mescaline, 143 for 2C-B, 206 for 2C-E, 101 for 2C-T-2, 36 for DOB, 32 for DOI, 23 for DOM, 19 for TMA-2, 63 for MDA, 770 for MDMA, 236 for DMT, 247 for 5-MeO-DMT, 69 for 5-MeO-MiPT, 45 for DiPT, 182 for 5-MeO-DiPT, 137 for DPT, 718 for LSD, 32 for ibogaine, 64 for 2C-C, 383 for 2C-I, 57 for 2C-P, 16 for 2C-T-4, 171 for 2C-T-7, 48 for 2C-D, 144 for 25I-NBOMe, 51 for 4-OH-MET, 109 for 5-MeO-AMT, 208 for 4-OH-DiPT and 8 for psilocin/psilocybin.
Sensory amplification: A deceptively simple tryptamine DIPT (N,N-diisopr()pyltryptamine) has been reported to amplify and distort the auditory sensory input signals (2) in preference to the more frequently seen visual distortions. This modality is closer to the usual symptomology of endogenous schizophrenia, and may well serve as a discriminating tool for differential research.
Auditory hallucinations can sometimes be triggered by the use of—or withdrawal from—illicit substances such as alcohol, cannabis, amphetamines, cocaine, [LSD], and [DMT]. Generally speaking, hallucinogens are more likely to induce visual than auditory misperceptions. If auditory misperceptions occur at all, they tend to do so in the context of compound hallucinations. A notable exception is diisopropyltryptamine (DiPT), a hallucinogenic of the tryptamine family, which primarily affects auditory pitch.
Other unsubstituted simple synthetic tryptamines are N,N-diallyltryptamine (DALT), diethyltryptamine (DET), di-isopropyltryptamine (DiPT) and dipropyltryptamine (DPT) (see Fig. 5). Each is active after ingestion, with serotonin-mediated visual hallucinations the main clinical effect. DiPT is unusual in that it produces primarily auditory hallucinations, with tinnitus as a side effect. 154
DiPT bound with moderate affinity to the 5-HT2C receptor (Ki= 290 ± 110 nM; Hill coefficient = −0.72 ± 0.05) and was a full agonist in the IP-1 formation assay (EC50 = 2380 ± 340 nM), producing 107.4 ± 2.5% of the maximal 5-HT effect.
A large body of anecdotal experiences supports the existence of differences in the subjective effects of serotonergic psychedelics, in particular concerning those elicited by relatively novel synthetic derivatives of phenethylamines (i.e., mescaline analogs) and tryptamines (i.e., DMT analogs). A frequently cited example is that of N,N-Diisopropyltryptamine (DiPT), a substituted tryptamine and 5-HT1A/2A agonist remarkable for producing auditory distortions, in contrast to the predominantly visual effects of classic psychedelics (Shulgin and Carter, 1979; Shulgin and Shulgin, 1997; Kometer and Vollenweider, 2016). [...] • DiPT (N,N-Diisopropyltryptamine): substituted tryptamine, first synthesized and tested by Shulgin and Carter (1979). [...] A total of 16 reports were obtained for mescaline, 143 for 2C-B, 206 for 2C-E, 101 for 2C-T-2, 36 for DOB, 32 for DOI, 23 for DOM, 19 for TMA-2, 63 for MDA, 770 for MDMA, 236 for DMT, 247 for 5-MeO-DMT, 69 for 5-MeO-MiPT, 45 for DiPT, 182 for 5-MeO-DiPT, 137 for DPT, 718 for LSD, 32 for ibogaine, 64 for 2C-C, 383 for 2C-I, 57 for 2C-P, 16 for 2C-T-4, 171 for 2C-T-7, 48 for 2C-D, 144 for 25I-NBOMe, 51 for 4-OH-MET, 109 for 5-MeO-AMT, 208 for 4-OH-DiPT and 8 for psilocin/psilocybin.
Auditory hallucinations can sometimes be triggered by the use of—or withdrawal from—illicit substances such as alcohol, cannabis, amphetamines, cocaine, [LSD], and [DMT]. Generally speaking, hallucinogens are more likely to induce visual than auditory misperceptions. If auditory misperceptions occur at all, they tend to do so in the context of compound hallucinations. A notable exception is diisopropyltryptamine (DiPT), a hallucinogenic of the tryptamine family, which primarily affects auditory pitch.
22.2.3.2 DiPT A member of the tryptamine chemical family, diisopropyltryptamine (DiPT) is a fascinating substance because, unlike most hallucinogens, its effects are predominantly auditory. It is also possibly less sensitive than other hallucinogens to the mindset of the user, the setting in which it is ingested, and other psychological considerations, perhaps because the auditory system has become less salient to the human organism as we have evolved into a vision-based species. In general, auditory pitch is perceived as lower than normal, and harmonious sounds lose their resonance with one another. This dissonance is even perceived by people with perfect pitch, which has some implications about where in the processing stream DiPT's effects occur. Voices are also altered and disharmonious with one another (Shulgin and Shulgin 1997 ) . DiPT has few other known effects; it would seem to call for further investigation from those interested in the neurology of sound, music, and verbal language processing. For example, it would be fascinating to know the effects of this substance on perceptions of tonal languages such as Chinese, Huichol, or Dogon; would it alter the words perceived as being spoken?
Sensory amplification: A deceptively simple tryptamine DIPT (N,N-diisopr()pyltryptamine) has been reported to amplify and distort the auditory sensory input signals (2) in preference to the more frequently seen visual distortions. This modality is closer to the usual symptomology of endogenous schizophrenia, and may well serve as a discriminating tool for differential research.
