References analysis of the Wikipedia article "Dihydrofolate reductase" in the English version

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Chen MJ, Shimada T, Moulton AD, Harrison M, Nienhuis AW (December 1982). "Intronless human dihydrofolate reductase genes are derived from processed RNA molecules". Proceedings of the National Academy of Sciences of the United States of America. 79 (23): 7435–9. Bibcode:1982PNAS...79.7435C. doi:10.1073/pnas.79.23.7435. PMC 347354. PMID 6961421.

Chen MJ, Shimada T, Moulton AD, Cline A, Humphries RK, Maizel J, Nienhuis AW (March 1984). "The functional human dihydrofolate reductase gene". The Journal of Biological Chemistry. 259 (6): 3933–43. doi:10.1016/S0021-9258(17)43186-3. PMID 6323448.

Smith SL, Patrick P, Stone D, Phillips AW, Burchall JJ (November 1979). "Porcine liver dihydrofolate reductase. Purification, properties, and amino acid sequence". The Journal of Biological Chemistry. 254 (22): 11475–84. doi:10.1016/S0021-9258(19)86510-9. PMID 500653.

Krahn JM, Jackson MR, DeRose EF, Howell EE, London RE (25 December 2007). "Crystal structure of a type II dihydrofolate reductase catalytic ternary complex". Biochemistry. 46 (51): 14878–88. doi:10.1021/bi701532r. PMC 3743094. PMID 18052202.

Schnell JR, Dyson HJ, Wright PE (2004). "Structure, dynamics, and catalytic function of dihydrofolate reductase". Annual Review of Biophysics and Biomolecular Structure. 33 (1): 119–40. doi:10.1146/annurev.biophys.33.110502.133613. PMID 15139807. S2CID 28611812.

Urlaub G, Chasin LA (July 1980). "Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity". Proceedings of the National Academy of Sciences of the United States of America. 77 (7): 4216–20. Bibcode:1980PNAS...77.4216U. doi:10.1073/pnas.77.7.4216. PMC 349802. PMID 6933469.

Crabtree MJ, Tatham AL, Hale AB, Alp NJ, Channon KM (October 2009). "Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways". The Journal of Biological Chemistry. 284 (41): 28128–36. doi:10.1074/jbc.M109.041483. PMC 2788863. PMID 19666465.

Matthews DA, Alden RA, Bolin JT, Freer ST, Hamlin R, Xuong N, Kraut J, Poe M, Williams M, Hoogsteen K (July 1977). "Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate". Science. 197 (4302): 452–5. Bibcode:1977Sci...197..452M. doi:10.1126/science.17920. PMID 17920.

Filman DJ, Bolin JT, Matthews DA, Kraut J (November 1982). "Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 Å resolution. II. Environment of bound NADPH and implications for catalysis". The Journal of Biological Chemistry. 257 (22): 13663–72. doi:10.1016/S0021-9258(18)33498-7. PMID 6815179.

Osborne MJ, Schnell J, Benkovic SJ, Dyson HJ, Wright PE (August 2001). "Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism". Biochemistry. 40 (33): 9846–59. doi:10.1021/bi010621k. PMID 11502178.

Rod TH, Brooks CL (July 2003). "How dihydrofolate reductase facilitates protonation of dihydrofolate". Journal of the American Chemical Society. 125 (29): 8718–9. doi:10.1021/ja035272r. PMID 12862454.

Wan Q, Bennett BC, Wilson MA, Kovalevsky A, Langan P, Howell EE, Dealwis C (December 2014). "Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography". Proceedings of the National Academy of Sciences of the United States of America. 111 (51): 18225–30. Bibcode:2014PNAS..11118225W. doi:10.1073/pnas.1415856111. PMC 4280638. PMID 25453083.

Liu CT, Francis K, Layfield JP, Huang X, Hammes-Schiffer S, Kohen A, Benkovic SJ (December 2014). "Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: temporal order and the roles of Asp27 and Tyr100". Proceedings of the National Academy of Sciences of the United States of America. 111 (51): 18231–6. Bibcode:2014PNAS..11118231L. doi:10.1073/pnas.1415940111. PMC 4280594. PMID 25453098.

Czekster CM, Vandemeulebroucke A, Blanchard JS (January 2011). "Kinetic and chemical mechanism of the dihydrofolate reductase from Mycobacterium tuberculosis". Biochemistry. 50 (3): 367–75. doi:10.1021/bi1016843. PMC 3074011. PMID 21138249.

Fierke CA, Johnson KA, Benkovic SJ (June 1987). "Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli". Biochemistry. 26 (13): 4085–92. doi:10.1021/bi00387a052. PMID 3307916.

Reyes VM, Sawaya MR, Brown KA, Kraut J (February 1995). "Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications". Biochemistry. 34 (8): 2710–23. doi:10.1021/bi00008a039. PMID 7873554.

Sawaya MR, Kraut J (January 1997). "Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence". Biochemistry. 36 (3): 586–603. doi:10.1021/bi962337c. PMID 9012674.

Chen YQ, Kraut J, Blakley RL, Callender R (June 1994). "Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications". Biochemistry. 33 (23): 7021–6. doi:10.1021/bi00189a001. PMID 8003467.

Shrimpton P, Allemann RK (June 2002). "Role of water in the catalytic cycle of E. coli dihydrofolate reductase". Protein Science. 11 (6): 1442–51. doi:10.1110/ps.5060102. PMC 2373639. PMID 12021443.

Antikainen NM, Smiley RD, Benkovic SJ, Hammes GG (December 2005). "Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase". Biochemistry. 44 (51): 16835–43. doi:10.1021/bi051378i. PMID 16363797.

Narayana N, Matthews DA, Howell EE, Nguyen-huu X (November 1995). "A plasmid-encoded dihydrofolate reductase from trimethoprim-resistant bacteria has a novel D2-symmetric active site". Nature Structural Biology. 2 (11): 1018–25. doi:10.1038/nsb1195-1018. PMID 7583655. S2CID 11914241.

Bradrick TD, Beechem JM, Howell EE (September 1996). "Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein". Biochemistry. 35 (35): 11414–24. doi:10.1021/bi960205d. PMID 8784197.

Park H, Zhuang P, Nichols R, Howell EE (January 1997). "Mechanistic studies of R67 dihydrofolate reductase. Effects of pH and an H62C mutation". The Journal of Biological Chemistry. 272 (4): 2252–8. doi:10.1074/jbc.272.4.2252. PMID 8999931.

Kamath G, Howell EE, Agarwal PK (October 2010). "The tail wagging the dog: insights into catalysis in R67 dihydrofolate reductase". Biochemistry. 49 (42): 9078–88. doi:10.1021/bi1007222. PMID 20795731.

Banka S, Blom HJ, Walter J, Aziz M, Urquhart J, Clouthier CM, Rice GI, de Brouwer AP, Hilton E, Vassallo G, Will A, Smith DE, Smulders YM, Wevers RA, Steinfeld R, Heales S, Crow YJ, Pelletier JN, Jones S, Newman WG (February 2011). "Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency". American Journal of Human Genetics. 88 (2): 216–25. doi:10.1016/j.ajhg.2011.01.004. PMC 3035707. PMID 21310276.

Cowman AF, Lew AM (November 1989). "Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudi". Molecular and Cellular Biology. 9 (11): 5182–8. doi:10.1128/mcb.9.11.5182. PMC 363670. PMID 2601715.

Li R, Sirawaraporn R, Chitnumsub P, Sirawaraporn W, Wooden J, Athappilly F, Turley S, Hol WG (January 2000). "Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs". Journal of Molecular Biology. 295 (2): 307–23. doi:10.1006/jmbi.1999.3328. PMID 10623528. S2CID 24527344.

Bailey SW, Ayling JE (September 2009). "The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake". Proceedings of the National Academy of Sciences of the United States of America. 106 (36): 15424–9. doi:10.1073/pnas.0902072106. PMC 2730961. PMID 19706381.

Murad AM, Santiago FF, Petroianu A, Rocha PR, Rodrigues MA, Rausch M (July 1993). "Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer". Cancer. 72 (1): 37–41. doi:10.1002/1097-0142(19930701)72:1<37::AID-CNCR2820720109>3.0.CO;2-P. PMID 8508427.

Hawser S, Lociuro S, Islam K (March 2006). "Dihydrofolate reductase inhibitors as antibacterial agents". Biochemical Pharmacology. 71 (7): 941–8. doi:10.1016/j.bcp.2005.10.052. PMID 16359642.

Huennekens FM (June 1996). "In search of dihydrofolate reductase". Protein Science. 5 (6): 1201–8. doi:10.1002/pro.5560050626. PMC 2143423. PMID 8762155.

Banerjee D, Mayer-Kuckuk P, Capiaux G, Budak-Alpdogan T, Gorlick R, Bertino JR (July 2002). "Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1587 (2–3): 164–73. doi:10.1016/S0925-4439(02)00079-0. PMID 12084458.

Toprak E, Veres A, Michel JB, Chait R, Hartl DL, Kishony R (December 2011). "Evolutionary paths to antibiotic resistance under dynamically sustained drug selection". Nature Genetics. 44 (1): 101–5. doi:10.1038/ng.1034. PMC 3534735. PMID 22179135.

Rodrigues JV, Bershtein S, Li A, Lozovsky ER, Hartl DL, Shakhnovich EI (March 2016). "Biophysical principles predict fitness landscapes of drug resistance". Proceedings of the National Academy of Sciences of the United States of America. 113 (11): E1470-8. Bibcode:2016PNAS..113E1470R. doi:10.1073/pnas.1601441113. PMC 4801265. PMID 26929328.

Benkovic SJ, Fierke CA, Naylor AM (March 1988). "Insights into enzyme function from studies on mutants of dihydrofolate reductase". Science. 239 (4844): 1105–10. Bibcode:1988Sci...239.1105B. doi:10.1126/science.3125607. PMID 3125607.

Beierlein JM, Karri NG, Anderson AC (October 2010). "Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationships". Journal of Medicinal Chemistry. 53 (20): 7327–36. doi:10.1021/jm100727t. PMC 3618964. PMID 20882962.

Tarassov K, Messier V, Landry CR, Radinovic S, Serna Molina MM, Shames I, Malitskaya Y, Vogel J, Bussey H, Michnick SW (June 2008). "An in vivo map of the yeast protein interactome" (PDF). Science. 320 (5882): 1465–70. Bibcode:2008Sci...320.1465T. doi:10.1126/science.1153878. PMID 18467557. S2CID 1732896.

Ng SK (2012). "Generation of High-Expressing Cells by Methotrexate Amplification of Destabilized Dihydrofolate Reductase Selection Marker". Protein Expression in Mammalian Cells. Methods in Molecular Biology. Vol. 801. pp. 161–172. doi:10.1007/978-1-61779-352-3_11. ISBN 978-1-61779-351-6. PMID 21987253.

Mayhew M, da Silva AC, Martin J, Erdjument-Bromage H, Tempst P, Hartl FU (February 1996). "Protein folding in the central cavity of the GroEL-GroES chaperonin complex". Nature. 379 (6564): 420–6. Bibcode:1996Natur.379..420M. doi:10.1038/379420a0. PMID 8559246. S2CID 4310511.

Maguire M, Nield PC, Devling T, Jenkins RE, Park BK, Polański R, Vlatković N, Boyd MT (May 2008). "MDM2 regulates dihydrofolate reductase activity through monoubiquitination". Cancer Research. 68 (9): 3232–42. doi:10.1158/0008-5472.CAN-07-5271. PMC 3536468. PMID 18451149.

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Hawser S, Lociuro S, Islam K (March 2006). "Dihydrofolate reductase inhibitors as antibacterial agents". Biochemical Pharmacology. 71 (7): 941–8. doi:10.1016/j.bcp.2005.10.052. PMID 16359642.

Huennekens FM (June 1996). "In search of dihydrofolate reductase". Protein Science. 5 (6): 1201–8. doi:10.1002/pro.5560050626. PMC 2143423. PMID 8762155.

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The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Dihydrofolate reductase (English Wikipedia)

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