Downregulation and upregulation (English Wikipedia)

Franz, Marion J. (2000). "Protein Controversies in Diabetes". Diabetes Spectrum. 13 (3). Archived from the original on 2016-03-05. Retrieved 2016-11-20.

doi.org (Global: 2^nd place; English: 2^nd place)

Atkinson, Taylor J; Halfon, Marc S (2014-01-01). "Regulation of Gene Expression in the Genomic Context". Computational and Structural Biotechnology Journal. 9 (13): e201401001. doi:10.5936/csbj.201401001. ISSN 2001-0370. PMC 3962188. PMID 24688749.{{cite journal}}: CS1 maint: article number as page number (link)
Krupp, M; Lane, MD (25 February 1981). "On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell". The Journal of Biological Chemistry. 256 (4): 1689–94. doi:10.1016/S0021-9258(19)69862-5. PMID 7007369.
Zaliauskiene, Lolita; Kang, Sunghyun; Brouillette, Christie G.; Lebowitz, Jacob; Arani, Ramin B.; Collawn, James F. (2016). "Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain". Molecular Biology of the Cell. 11 (8): 2643–2655. doi:10.1091/mbc.11.8.2643. ISSN 1059-1524. PMC 14946. PMID 10930460.
Carpentier, J.-L. (1994). "Insulin receptor internalization: molecular mechanisms and physiopathological implications". Diabetologia. 37 (2): S117 – S124. doi:10.1007/BF00400835. ISSN 0012-186X. PMID 7821727.
Fröjdö, Sara; Vidal, Hubert; Pirola, Luciano (2009-02-01). "Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1792 (2): 83–92. doi:10.1016/j.bbadis.2008.10.019. PMID 19041393.
Walker, Deena M.; Nestler, Eric J. (2018). "Neuroepigenetics and addiction". Handbook of Clinical Neurology. Vol. 148. pp. 747–765. doi:10.1016/B978-0-444-64076-5.00048-X. ISBN 9780444640765. PMC 5868351. PMID 29478612.
Nestler, Eric J. (January 2014). "Epigenetic mechanisms of drug addiction". Neuropharmacology. 76 Pt B: 259–68. doi:10.1016/j.neuropharm.2013.04.004. PMC 3766384. PMID 23643695.
O'Hagan, Heather M.; Mohammad, Helai P.; Baylin, Stephen B. (15 August 2008). "Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island". PLOS Genetics. 4 (8): e1000155. doi:10.1371/journal.pgen.1000155. PMC 2491723. PMID 18704159. Taken together, our data suggest that normal repair of a DNA break can occasionally cause heritable silencing of a CpG island–containing promoter by recruitment of proteins involved in silencing...This finding suggests that DNA damage may directly contribute to the large number of epigenetically silenced genes in tumors.{{cite journal}}: CS1 maint: article number as page number (link)
Cuozzo, Concetta; Porcellini, Antonio; Angrisano, Tiziana; Morano, Annalisa; Lee, Bongyong; Pardo, Alba Di; Messina, Samantha; Iuliano, Rodolfo; Fusco, Alfredo; Santillo, Maria R; Muller, Mark T; Chiariotti, Lorenzo; Gottesman, Max E; Avvedimento, Enrico V (6 July 2007). "DNA Damage, Homology-Directed Repair, and DNA Methylation". PLOS Genetics. 3 (7): e110. doi:10.1371/journal.pgen.0030110. PMC 1913100. PMID 17616978. ...data support a mechanistic link between HR and DNA methylation and suggest that DNA methylation in eukaryotes marks homologous recombined segments.
Baxter, Eva; Windloch, Karolina; Gannon, Frank; Lee, Jason S (December 2014). "Epigenetic regulation in cancer progression". Cell & Bioscience. 4 (1): 45. doi:10.1186/2045-3701-4-45. PMC 4422217. PMID 25949794.
Bilgrami, Shumaila M; Qureshi, Sohail A; Pervez, Shahid; Abbas, Farhat (December 2014). "Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer". SpringerPlus. 3 (1): 178. doi:10.1186/2193-1801-3-178. PMC 4000596. PMID 24790823.
Muvarak, Nidal; Kelley, Shannon; Robert, Carine; Baer, Maria R.; Perrotti, Danilo; Gambacorti-Passerini, Carlo; Civin, Curt; Scheibner, Kara; Rassool, Feyruz V. (1 April 2015). "c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated Leukemias". Molecular Cancer Research. 13 (4): 699–712. doi:10.1158/1541-7786.MCR-14-0422. PMC 4398615. PMID 25828893.
Newman, Erika A.; Lu, Fujia; Bashllari, Daniela; Wang, Li; Opipari, Anthony W.; Castle, Valerie P. (1 March 2015). "Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma". Molecular Cancer Research. 13 (3): 470–482. doi:10.1158/1541-7786.MCR-14-0337. PMID 25563294. S2CID 1830505.
Mego, Michal; Cierna, Zuzana; Svetlovska, Daniela; Macak, Dusan; Machalekova, Katarina; Miskovska, Viera; Chovanec, Michal; Usakova, Vanda; Obertova, Jana; Babal, Pavel; Mardiak, Jozef (July 2013). "PARP expression in germ cell tumours". Journal of Clinical Pathology. 66 (7): 607–612. doi:10.1136/jclinpath-2012-201088. PMID 23486608. S2CID 535704.
Newman, Robert; Soldatenkov, Viatcheslav; Dritschilo, Anatoly; Notario, Vicente (1 May 2002). "Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells". Oncology Reports. 9 (3): 529–532. doi:10.3892/or.9.3.529. PMID 11956622.
Xu, H; Zheng, L; Dai, H; Zhou, M; Hua, Y; Shen, B (2011). "Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice". Oncogene. 30 (9): 1072–1081. doi:10.1038/onc.2010.482. PMC 3832200. PMID 20972458.

figshare.com (Global: 5,893^rd place; English: 3,320^th place)

Newman, Erika A.; Lu, Fujia; Bashllari, Daniela; Wang, Li; Opipari, Anthony W.; Castle, Valerie P. (1 March 2015). "Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma". Molecular Cancer Research. 13 (3): 470–482. doi:10.1158/1541-7786.MCR-14-0337. PMID 25563294. S2CID 1830505.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Atkinson, Taylor J; Halfon, Marc S (2014-01-01). "Regulation of Gene Expression in the Genomic Context". Computational and Structural Biotechnology Journal. 9 (13): e201401001. doi:10.5936/csbj.201401001. ISSN 2001-0370. PMC 3962188. PMID 24688749.{{cite journal}}: CS1 maint: article number as page number (link)
Krupp, M; Lane, MD (25 February 1981). "On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell". The Journal of Biological Chemistry. 256 (4): 1689–94. doi:10.1016/S0021-9258(19)69862-5. PMID 7007369.
Zaliauskiene, Lolita; Kang, Sunghyun; Brouillette, Christie G.; Lebowitz, Jacob; Arani, Ramin B.; Collawn, James F. (2016). "Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain". Molecular Biology of the Cell. 11 (8): 2643–2655. doi:10.1091/mbc.11.8.2643. ISSN 1059-1524. PMC 14946. PMID 10930460.
Carpentier, J.-L. (1994). "Insulin receptor internalization: molecular mechanisms and physiopathological implications". Diabetologia. 37 (2): S117 – S124. doi:10.1007/BF00400835. ISSN 0012-186X. PMID 7821727.
Fröjdö, Sara; Vidal, Hubert; Pirola, Luciano (2009-02-01). "Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1792 (2): 83–92. doi:10.1016/j.bbadis.2008.10.019. PMID 19041393.
Wilcox, Gisela (2016-11-20). "Insulin and Insulin Resistance". Clinical Biochemist Reviews. 26 (2): 19–39. ISSN 0159-8090. PMC 1204764. PMID 16278749.
Walker, Deena M.; Nestler, Eric J. (2018). "Neuroepigenetics and addiction". Handbook of Clinical Neurology. Vol. 148. pp. 747–765. doi:10.1016/B978-0-444-64076-5.00048-X. ISBN 9780444640765. PMC 5868351. PMID 29478612.
Nestler, Eric J. (January 2014). "Epigenetic mechanisms of drug addiction". Neuropharmacology. 76 Pt B: 259–68. doi:10.1016/j.neuropharm.2013.04.004. PMC 3766384. PMID 23643695.
O'Hagan, Heather M.; Mohammad, Helai P.; Baylin, Stephen B. (15 August 2008). "Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island". PLOS Genetics. 4 (8): e1000155. doi:10.1371/journal.pgen.1000155. PMC 2491723. PMID 18704159. Taken together, our data suggest that normal repair of a DNA break can occasionally cause heritable silencing of a CpG island–containing promoter by recruitment of proteins involved in silencing...This finding suggests that DNA damage may directly contribute to the large number of epigenetically silenced genes in tumors.{{cite journal}}: CS1 maint: article number as page number (link)
Cuozzo, Concetta; Porcellini, Antonio; Angrisano, Tiziana; Morano, Annalisa; Lee, Bongyong; Pardo, Alba Di; Messina, Samantha; Iuliano, Rodolfo; Fusco, Alfredo; Santillo, Maria R; Muller, Mark T; Chiariotti, Lorenzo; Gottesman, Max E; Avvedimento, Enrico V (6 July 2007). "DNA Damage, Homology-Directed Repair, and DNA Methylation". PLOS Genetics. 3 (7): e110. doi:10.1371/journal.pgen.0030110. PMC 1913100. PMID 17616978. ...data support a mechanistic link between HR and DNA methylation and suggest that DNA methylation in eukaryotes marks homologous recombined segments.
Baxter, Eva; Windloch, Karolina; Gannon, Frank; Lee, Jason S (December 2014). "Epigenetic regulation in cancer progression". Cell & Bioscience. 4 (1): 45. doi:10.1186/2045-3701-4-45. PMC 4422217. PMID 25949794.
Bilgrami, Shumaila M; Qureshi, Sohail A; Pervez, Shahid; Abbas, Farhat (December 2014). "Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer". SpringerPlus. 3 (1): 178. doi:10.1186/2193-1801-3-178. PMC 4000596. PMID 24790823.
Muvarak, Nidal; Kelley, Shannon; Robert, Carine; Baer, Maria R.; Perrotti, Danilo; Gambacorti-Passerini, Carlo; Civin, Curt; Scheibner, Kara; Rassool, Feyruz V. (1 April 2015). "c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated Leukemias". Molecular Cancer Research. 13 (4): 699–712. doi:10.1158/1541-7786.MCR-14-0422. PMC 4398615. PMID 25828893.
Newman, Erika A.; Lu, Fujia; Bashllari, Daniela; Wang, Li; Opipari, Anthony W.; Castle, Valerie P. (1 March 2015). "Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma". Molecular Cancer Research. 13 (3): 470–482. doi:10.1158/1541-7786.MCR-14-0337. PMID 25563294. S2CID 1830505.
Mego, Michal; Cierna, Zuzana; Svetlovska, Daniela; Macak, Dusan; Machalekova, Katarina; Miskovska, Viera; Chovanec, Michal; Usakova, Vanda; Obertova, Jana; Babal, Pavel; Mardiak, Jozef (July 2013). "PARP expression in germ cell tumours". Journal of Clinical Pathology. 66 (7): 607–612. doi:10.1136/jclinpath-2012-201088. PMID 23486608. S2CID 535704.
Newman, Robert; Soldatenkov, Viatcheslav; Dritschilo, Anatoly; Notario, Vicente (1 May 2002). "Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells". Oncology Reports. 9 (3): 529–532. doi:10.3892/or.9.3.529. PMID 11956622.
Xu, H; Zheng, L; Dai, H; Zhou, M; Hua, Y; Shen, B (2011). "Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice". Oncogene. 30 (9): 1072–1081. doi:10.1038/onc.2010.482. PMC 3832200. PMID 20972458.

ncbi.nlm.nih.gov

Atkinson, Taylor J; Halfon, Marc S (2014-01-01). "Regulation of Gene Expression in the Genomic Context". Computational and Structural Biotechnology Journal. 9 (13): e201401001. doi:10.5936/csbj.201401001. ISSN 2001-0370. PMC 3962188. PMID 24688749.{{cite journal}}: CS1 maint: article number as page number (link)
Zaliauskiene, Lolita; Kang, Sunghyun; Brouillette, Christie G.; Lebowitz, Jacob; Arani, Ramin B.; Collawn, James F. (2016). "Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain". Molecular Biology of the Cell. 11 (8): 2643–2655. doi:10.1091/mbc.11.8.2643. ISSN 1059-1524. PMC 14946. PMID 10930460.
Wilcox, Gisela (2016-11-20). "Insulin and Insulin Resistance". Clinical Biochemist Reviews. 26 (2): 19–39. ISSN 0159-8090. PMC 1204764. PMID 16278749.
Walker, Deena M.; Nestler, Eric J. (2018). "Neuroepigenetics and addiction". Handbook of Clinical Neurology. Vol. 148. pp. 747–765. doi:10.1016/B978-0-444-64076-5.00048-X. ISBN 9780444640765. PMC 5868351. PMID 29478612.
Nestler, Eric J. (January 2014). "Epigenetic mechanisms of drug addiction". Neuropharmacology. 76 Pt B: 259–68. doi:10.1016/j.neuropharm.2013.04.004. PMC 3766384. PMID 23643695.
O'Hagan, Heather M.; Mohammad, Helai P.; Baylin, Stephen B. (15 August 2008). "Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island". PLOS Genetics. 4 (8): e1000155. doi:10.1371/journal.pgen.1000155. PMC 2491723. PMID 18704159. Taken together, our data suggest that normal repair of a DNA break can occasionally cause heritable silencing of a CpG island–containing promoter by recruitment of proteins involved in silencing...This finding suggests that DNA damage may directly contribute to the large number of epigenetically silenced genes in tumors.{{cite journal}}: CS1 maint: article number as page number (link)
Cuozzo, Concetta; Porcellini, Antonio; Angrisano, Tiziana; Morano, Annalisa; Lee, Bongyong; Pardo, Alba Di; Messina, Samantha; Iuliano, Rodolfo; Fusco, Alfredo; Santillo, Maria R; Muller, Mark T; Chiariotti, Lorenzo; Gottesman, Max E; Avvedimento, Enrico V (6 July 2007). "DNA Damage, Homology-Directed Repair, and DNA Methylation". PLOS Genetics. 3 (7): e110. doi:10.1371/journal.pgen.0030110. PMC 1913100. PMID 17616978. ...data support a mechanistic link between HR and DNA methylation and suggest that DNA methylation in eukaryotes marks homologous recombined segments.
Baxter, Eva; Windloch, Karolina; Gannon, Frank; Lee, Jason S (December 2014). "Epigenetic regulation in cancer progression". Cell & Bioscience. 4 (1): 45. doi:10.1186/2045-3701-4-45. PMC 4422217. PMID 25949794.
Bilgrami, Shumaila M; Qureshi, Sohail A; Pervez, Shahid; Abbas, Farhat (December 2014). "Promoter hypermethylation of tumor suppressor genes correlates with tumor grade and invasiveness in patients with urothelial bladder cancer". SpringerPlus. 3 (1): 178. doi:10.1186/2193-1801-3-178. PMC 4000596. PMID 24790823.
Muvarak, Nidal; Kelley, Shannon; Robert, Carine; Baer, Maria R.; Perrotti, Danilo; Gambacorti-Passerini, Carlo; Civin, Curt; Scheibner, Kara; Rassool, Feyruz V. (1 April 2015). "c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated Leukemias". Molecular Cancer Research. 13 (4): 699–712. doi:10.1158/1541-7786.MCR-14-0422. PMC 4398615. PMID 25828893.
Xu, H; Zheng, L; Dai, H; Zhou, M; Hua, Y; Shen, B (2011). "Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice". Oncogene. 30 (9): 1072–1081. doi:10.1038/onc.2010.482. PMC 3832200. PMID 20972458.

semanticscholar.org (Global: 11^th place; English: 8^th place)

api.semanticscholar.org

Newman, Erika A.; Lu, Fujia; Bashllari, Daniela; Wang, Li; Opipari, Anthony W.; Castle, Valerie P. (1 March 2015). "Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma". Molecular Cancer Research. 13 (3): 470–482. doi:10.1158/1541-7786.MCR-14-0337. PMID 25563294. S2CID 1830505.
Mego, Michal; Cierna, Zuzana; Svetlovska, Daniela; Macak, Dusan; Machalekova, Katarina; Miskovska, Viera; Chovanec, Michal; Usakova, Vanda; Obertova, Jana; Babal, Pavel; Mardiak, Jozef (July 2013). "PARP expression in germ cell tumours". Journal of Clinical Pathology. 66 (7): 607–612. doi:10.1136/jclinpath-2012-201088. PMID 23486608. S2CID 535704.

web.archive.org (Global: 1^st place; English: 1^st place)

Franz, Marion J. (2000). "Protein Controversies in Diabetes". Diabetes Spectrum. 13 (3). Archived from the original on 2016-03-05. Retrieved 2016-11-20.

worldcat.org (Global: 5^th place; English: 5^th place)

search.worldcat.org

Atkinson, Taylor J; Halfon, Marc S (2014-01-01). "Regulation of Gene Expression in the Genomic Context". Computational and Structural Biotechnology Journal. 9 (13): e201401001. doi:10.5936/csbj.201401001. ISSN 2001-0370. PMC 3962188. PMID 24688749.{{cite journal}}: CS1 maint: article number as page number (link)
Zaliauskiene, Lolita; Kang, Sunghyun; Brouillette, Christie G.; Lebowitz, Jacob; Arani, Ramin B.; Collawn, James F. (2016). "Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain". Molecular Biology of the Cell. 11 (8): 2643–2655. doi:10.1091/mbc.11.8.2643. ISSN 1059-1524. PMC 14946. PMID 10930460.
Carpentier, J.-L. (1994). "Insulin receptor internalization: molecular mechanisms and physiopathological implications". Diabetologia. 37 (2): S117 – S124. doi:10.1007/BF00400835. ISSN 0012-186X. PMID 7821727.
Wilcox, Gisela (2016-11-20). "Insulin and Insulin Resistance". Clinical Biochemist Reviews. 26 (2): 19–39. ISSN 0159-8090. PMC 1204764. PMID 16278749.

Downregulation and upregulation (English Wikipedia)

books.google.com (Global: 3rd place; English: 3rd place)

diabetes.org (Global: low place; English: low place)

journal.diabetes.org

doi.org (Global: 2nd place; English: 2nd place)

figshare.com (Global: 5,893rd place; English: 3,320th place)

nih.gov (Global: 4th place; English: 4th place)

pubmed.ncbi.nlm.nih.gov

ncbi.nlm.nih.gov

semanticscholar.org (Global: 11th place; English: 8th place)

api.semanticscholar.org

web.archive.org (Global: 1st place; English: 1st place)

worldcat.org (Global: 5th place; English: 5th place)

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books.google.com (Global: 3^rd place; English: 3^rd place)

doi.org (Global: 2^nd place; English: 2^nd place)

figshare.com (Global: 5,893^rd place; English: 3,320^th place)

nih.gov (Global: 4^th place; English: 4^th place)

semanticscholar.org (Global: 11^th place; English: 8^th place)

web.archive.org (Global: 1^st place; English: 1^st place)

worldcat.org (Global: 5^th place; English: 5^th place)