Epothilone (English Wikipedia)

Forli, Stefano (2014). "Epothilones: from discovery to clinical trials". Current Topics in Medicinal Chemistry. 14 (20): 2312–2321. doi:10.2174/1568026614666141130095855. PMC 4629788. PMID 25434353.
Avendaño, Carmen; Menéndez, J. Carlos (2023). "Anticancer drugs targeting tubulin and microtubules". Medicinal Chemistry of Anticancer Drugs. pp. 445–491. doi:10.1016/B978-0-12-818549-0.00017-0. ISBN 978-0-12-818549-0. The epothilones A and B are naturally occurring 16-membered macrolides that were isolated in 1993 from the myxobacterium Sorangium cellulosum and first employed as agrochemical antifungal agents.
Julien, Bryan; Shah, Sanjay (September 2002). "Heterologous Expression of Epothilone Biosynthetic Genes in Myxococcus xanthus". Antimicrobial Agents and Chemotherapy. 46 (9): 2772–2778. doi:10.1128/AAC.46.9.2772-2778.2002. PMC 127399. PMID 12183227.
Höfle, Gerhard; Bedorf, Norbert; Steinmetz, Heinrich; Schomburg, Dietmar; Gerth, Klaus; Reichenbach, Hans (July 1996). "Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution". Angewandte Chemie International Edition in English. 35 (13–14): 1567–1569. doi:10.1002/anie.199615671.
Goodin, Susan; Kane, Michael P.; Rubin, Eric H. (15 May 2004). "Epothilones: Mechanism of Action and Biologic Activity". Journal of Clinical Oncology. 22 (10): 2015–2025. doi:10.1200/JCO.2004.12.001. PMID 15143095.
Balog, Aaron; Meng, Dongfang; Kamenecka, Ted; Bertinato, Peter; Su, Dai-Shi; Sorensen, Erik J.; Danishefsky, Samuel J. (16 December 1996). "Totalsynthese von (—)-Epothilon A". Angewandte Chemie. 108 (23–24): 2976–2978. Bibcode:1996AngCh.108.2976B. doi:10.1002/ange.19961082318.
Jordan, Mary Ann; Wilson, Leslie (April 2004). "Microtubules as a target for anticancer drugs". Nature Reviews Cancer. 4 (4): 253–265. doi:10.1038/nrc1317. PMID 15057285.
Ganguly, Anutosh; Yang, Hailing; Cabral, Fernando (November 2010). "Paclitaxel-Dependent Cell Lines Reveal a Novel Drug Activity". Molecular Cancer Therapeutics. 9 (11): 2914–2923. doi:10.1158/1535-7163.MCT-10-0552. PMC 2978777. PMID 20978163.
Villegas, Cecilia; González-Chavarría, Iván; Burgos, Viviana; Iturra-Beiza, Héctor; Ulrich, Henning; Paz, Cristian (January 2023). "Epothilones as Natural Compounds for Novel Anticancer Drugs Development". International Journal of Molecular Sciences. 24 (7): 6063. doi:10.3390/ijms24076063. PMC 10093981. PMID 37047035.
Anticancer Agents. ACS Symposium Series. Vol. 796. 2001. doi:10.1021/bk-2001-0796. ISBN 978-0-8412-3745-2.^{[page needed]}
Luduvico, Inacio; Hyaric, Mireille L.; Almeida, Mauro V. De; Silva, Adilson D. Da (2006). "Synthetic Methodologies for the Preparation of Epothilones and Analogs". Mini-Reviews in Organic Chemistry. 3 (1): 49–75. doi:10.2174/157019306775474194.^{[predatory publisher]}
Su, Dai-Shi; Meng, Dongfang; Bertinato, Peter; Balog, Aaron; Sorensen, Erik J.; Danishefsky, Samuel J.; Zheng, Yu-Huang; Chou, Ting-Chao; He, Lifeng; Horwitz, Susan B. (18 April 1997). "Total Synthesis of (–)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones". Angewandte Chemie International Edition in English. 36 (7): 757–759. doi:10.1002/anie.199707571.
Yang, Zhen; He, Yun; Vourloumis, Dionisios; Vallberg, Hans; Nicolaou, K. C. (3 February 1997). "Total Synthesis of Epothilone A: The Olefin Metathesis Approach". Angewandte Chemie International Edition in English. 36 (1–2): 166–168. doi:10.1002/anie.199701661.
Schinzer, Dieter; Limberg, Anja; Bauer, Armin; Böhm, Oliver M.; Cordes, Martin (14 March 1997). "Total Synthesis of (−)-Epothilone A". Angewandte Chemie International Edition in English. 36 (5): 523–524. doi:10.1002/anie.199705231.
Mulzer, Johann; Mantoulidis, Andreas; Öhler, Elisabeth (November 2000). "Total Syntheses of Epothilones B and D". The Journal of Organic Chemistry. 65 (22): 7456–7467. doi:10.1021/jo0007480. PMID 11076603.
Bode, Jeffrey W.; Carreira, Erick M. (April 2001). "Stereoselective Syntheses of Epothilones A and B via Directed Nitrile Oxide Cycloaddition 1". Journal of the American Chemical Society. 123 (15): 3611–3612. Bibcode:2001JAChS.123.3611B. doi:10.1021/ja0155635. PMID 11472140.
Nicolaou, K. C.; Ninkovic, S.; Sarabia, F.; Vourloumis, D.; He, Y.; Vallberg, H.; Finlay, M. R. V.; Yang, Z. (August 1997). "Total Syntheses of Epothilones A and B via a Macrolactonization-Based Strategy". Journal of the American Chemical Society. 119 (34): 7974–7991. Bibcode:1997JAChS.119.7974N. doi:10.1021/ja971110h.
Molnár, I.; Schupp, T.; Ono, M.; Zirkle, R.; Milnamow, M.; Nowak-Thompson, B.; Engel, N.; Toupet, C.; Stratmann, A.; Cyr, D. D.; Gorlach, J.; Mayo, J. M.; Hu, A.; Goff, S.; Schmid, J.; Ligon, J. M. (February 2000). "The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90". Chemistry & Biology. 7 (2): 97–109. doi:10.1016/s1074-5521(00)00075-2. PMID 10662695.

harvard.edu (Global: 18^th place; English: 17^th place)

ui.adsabs.harvard.edu

Balog, Aaron; Meng, Dongfang; Kamenecka, Ted; Bertinato, Peter; Su, Dai-Shi; Sorensen, Erik J.; Danishefsky, Samuel J. (16 December 1996). "Totalsynthese von (—)-Epothilon A". Angewandte Chemie. 108 (23–24): 2976–2978. Bibcode:1996AngCh.108.2976B. doi:10.1002/ange.19961082318.
Bode, Jeffrey W.; Carreira, Erick M. (April 2001). "Stereoselective Syntheses of Epothilones A and B via Directed Nitrile Oxide Cycloaddition 1". Journal of the American Chemical Society. 123 (15): 3611–3612. Bibcode:2001JAChS.123.3611B. doi:10.1021/ja0155635. PMID 11472140.
Nicolaou, K. C.; Ninkovic, S.; Sarabia, F.; Vourloumis, D.; He, Y.; Vallberg, H.; Finlay, M. R. V.; Yang, Z. (August 1997). "Total Syntheses of Epothilones A and B via a Macrolactonization-Based Strategy". Journal of the American Chemical Society. 119 (34): 7974–7991. Bibcode:1997JAChS.119.7974N. doi:10.1021/ja971110h.

medicalnewstoday.com (Global: 3,011^th place; English: 2,709^th place)

"Medical News Today: FDA Approves IXEMPRA(TM) (ixabepilone), A Semi-Synthetic Analog Of Epothilone B, For The Treatment Of Advanced Breast Cancer". Archived from the original on 2011-05-16. Retrieved 2009-02-17.
"ESMO: Failed Trials Dominate Gyn Cancer Session". 14 October 2010. Archived from the original on 18 June 2010. Retrieved 26 October 2010.
"Phase III Ixabepilone Study Demonstrated Significant Improvement In Progression-Free Survival In Patients With Advanced Metastatic Breast Cancer". Medical News Today. 4 June 2007.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Forli, Stefano (2014). "Epothilones: from discovery to clinical trials". Current Topics in Medicinal Chemistry. 14 (20): 2312–2321. doi:10.2174/1568026614666141130095855. PMC 4629788. PMID 25434353.
Julien, Bryan; Shah, Sanjay (September 2002). "Heterologous Expression of Epothilone Biosynthetic Genes in Myxococcus xanthus". Antimicrobial Agents and Chemotherapy. 46 (9): 2772–2778. doi:10.1128/AAC.46.9.2772-2778.2002. PMC 127399. PMID 12183227.
Mühlradt, Peter F.; Sasse, Florenz (15 August 1997). "Epothilone B Stabilizes Microtubuli of Macrophages Like Taxol without Showing Taxol-like Endotoxin Activity". Cancer Research. 57 (16): 3344–3346. PMID 9269992.
Goodin, Susan; Kane, Michael P.; Rubin, Eric H. (15 May 2004). "Epothilones: Mechanism of Action and Biologic Activity". Journal of Clinical Oncology. 22 (10): 2015–2025. doi:10.1200/JCO.2004.12.001. PMID 15143095.
Jordan, Mary Ann; Wilson, Leslie (April 2004). "Microtubules as a target for anticancer drugs". Nature Reviews Cancer. 4 (4): 253–265. doi:10.1038/nrc1317. PMID 15057285.
Ganguly, Anutosh; Yang, Hailing; Cabral, Fernando (November 2010). "Paclitaxel-Dependent Cell Lines Reveal a Novel Drug Activity". Molecular Cancer Therapeutics. 9 (11): 2914–2923. doi:10.1158/1535-7163.MCT-10-0552. PMC 2978777. PMID 20978163.
Villegas, Cecilia; González-Chavarría, Iván; Burgos, Viviana; Iturra-Beiza, Héctor; Ulrich, Henning; Paz, Cristian (January 2023). "Epothilones as Natural Compounds for Novel Anticancer Drugs Development". International Journal of Molecular Sciences. 24 (7): 6063. doi:10.3390/ijms24076063. PMC 10093981. PMID 37047035.
Mulzer, Johann; Mantoulidis, Andreas; Öhler, Elisabeth (November 2000). "Total Syntheses of Epothilones B and D". The Journal of Organic Chemistry. 65 (22): 7456–7467. doi:10.1021/jo0007480. PMID 11076603.
Bode, Jeffrey W.; Carreira, Erick M. (April 2001). "Stereoselective Syntheses of Epothilones A and B via Directed Nitrile Oxide Cycloaddition 1". Journal of the American Chemical Society. 123 (15): 3611–3612. Bibcode:2001JAChS.123.3611B. doi:10.1021/ja0155635. PMID 11472140.
Molnár, I.; Schupp, T.; Ono, M.; Zirkle, R.; Milnamow, M.; Nowak-Thompson, B.; Engel, N.; Toupet, C.; Stratmann, A.; Cyr, D. D.; Gorlach, J.; Mayo, J. M.; Hu, A.; Goff, S.; Schmid, J.; Ligon, J. M. (February 2000). "The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90". Chemistry & Biology. 7 (2): 97–109. doi:10.1016/s1074-5521(00)00075-2. PMID 10662695.

ncbi.nlm.nih.gov

Forli, Stefano (2014). "Epothilones: from discovery to clinical trials". Current Topics in Medicinal Chemistry. 14 (20): 2312–2321. doi:10.2174/1568026614666141130095855. PMC 4629788. PMID 25434353.
Julien, Bryan; Shah, Sanjay (September 2002). "Heterologous Expression of Epothilone Biosynthetic Genes in Myxococcus xanthus". Antimicrobial Agents and Chemotherapy. 46 (9): 2772–2778. doi:10.1128/AAC.46.9.2772-2778.2002. PMC 127399. PMID 12183227.
Ganguly, Anutosh; Yang, Hailing; Cabral, Fernando (November 2010). "Paclitaxel-Dependent Cell Lines Reveal a Novel Drug Activity". Molecular Cancer Therapeutics. 9 (11): 2914–2923. doi:10.1158/1535-7163.MCT-10-0552. PMC 2978777. PMID 20978163.
Villegas, Cecilia; González-Chavarría, Iván; Burgos, Viviana; Iturra-Beiza, Héctor; Ulrich, Henning; Paz, Cristian (January 2023). "Epothilones as Natural Compounds for Novel Anticancer Drugs Development". International Journal of Molecular Sciences. 24 (7): 6063. doi:10.3390/ijms24076063. PMC 10093981. PMID 37047035.

web.archive.org (Global: 1^st place; English: 1^st place)

"Medical News Today: FDA Approves IXEMPRA(TM) (ixabepilone), A Semi-Synthetic Analog Of Epothilone B, For The Treatment Of Advanced Breast Cancer". Archived from the original on 2011-05-16. Retrieved 2009-02-17.
"ESMO: Failed Trials Dominate Gyn Cancer Session". 14 October 2010. Archived from the original on 18 June 2010. Retrieved 26 October 2010.

worldcat.org (Global: 5^th place; English: 5^th place)

search.worldcat.org

Rosenberg, Steven; DeVita, Vincent T.; Hellman, Samuel (2005). Cancer: Principles & Practice of Oncology (7th ed.). Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4450-8. OCLC 232304182.^{[page needed]}

Epothilone (English Wikipedia)

aacrjournals.org (Global: 8,869th place; English: 8,487th place)

archive.org (Global: 6th place; English: 6th place)

cancernetwork.com (Global: low place; English: low place)

diaglobal.org (Global: low place; English: low place)

globalforum.diaglobal.org

doi.org (Global: 2nd place; English: 2nd place)

harvard.edu (Global: 18th place; English: 17th place)

ui.adsabs.harvard.edu

medicalnewstoday.com (Global: 3,011th place; English: 2,709th place)

nih.gov (Global: 4th place; English: 4th place)

pubmed.ncbi.nlm.nih.gov

ncbi.nlm.nih.gov

web.archive.org (Global: 1st place; English: 1st place)

worldcat.org (Global: 5th place; English: 5th place)

search.worldcat.org

aacrjournals.org (Global: 8,869^th place; English: 8,487^th place)

archive.org (Global: 6^th place; English: 6^th place)

doi.org (Global: 2^nd place; English: 2^nd place)

harvard.edu (Global: 18^th place; English: 17^th place)

medicalnewstoday.com (Global: 3,011^th place; English: 2,709^th place)

nih.gov (Global: 4^th place; English: 4^th place)

web.archive.org (Global: 1^st place; English: 1^st place)

worldcat.org (Global: 5^th place; English: 5^th place)