Fatty acid synthase (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Fatty acid synthase" in English language version.

refsWebsite

Global rank English rank

57nih.gov

4^th place

40doi.org

2^nd place

9harvard.edu

18^th place

17^th place

8semanticscholar.org

11^th place

8^th place

1acs.org

1,248^th place

1,104^th place

1worldcat.org

5^th place

1sciencedirect.com

149^th place

178^th place

1web.archive.org

1^st place

1oncotherapynetwork.com

low place

1latrobe.edu.au

low place

9,741^st place

acs.org

pubs.acs.org

Paiva P, Medina FE, Viegas M, Ferreira P, Neves RP, Sousa JP, Ramos MJ, Fernandes PA (2021-08-11). "Animal Fatty Acid Synthase: A Chemical Nanofactory". Chemical Reviews. 121 (15): 9502–9553. doi:10.1021/acs.chemrev.1c00147. ISSN 0009-2665. PMID 34156235. S2CID 235595027.

doi.org

Paiva P, Medina FE, Viegas M, Ferreira P, Neves RP, Sousa JP, Ramos MJ, Fernandes PA (2021-08-11). "Animal Fatty Acid Synthase: A Chemical Nanofactory". Chemical Reviews. 121 (15): 9502–9553. doi:10.1021/acs.chemrev.1c00147. ISSN 0009-2665. PMID 34156235. S2CID 235595027.
Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ (February 1995). "Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene". Genomics. 23 (2): 420–424. doi:10.1006/geno.1994.1518. PMID 7835891.
Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ (Oct 1995). "Human fatty acid synthase: properties and molecular cloning". Proceedings of the National Academy of Sciences of the United States of America. 92 (19): 8695–8699. Bibcode:1995PNAS...92.8695J. doi:10.1073/pnas.92.19.8695. PMC 41033. PMID 7567999.
Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
Alberts AW, Strauss AW, Hennessy S, Vagelos PR (October 1975). "Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes". Proceedings of the National Academy of Sciences of the United States of America. 72 (10): 3956–3960. Bibcode:1975PNAS...72.3956A. doi:10.1073/pnas.72.10.3956. PMC 433116. PMID 1060077.
Stoops JK, Arslanian MJ, Oh YH, Aune KC, Vanaman TC, Wakil SJ (May 1975). "Presence of two polypeptide chains comprising fatty acid synthetase". Proceedings of the National Academy of Sciences of the United States of America. 72 (5): 1940–1944. Bibcode:1975PNAS...72.1940S. doi:10.1073/pnas.72.5.1940. PMC 432664. PMID 1098047.
Smith S, Agradi E, Libertini L, Dileepan KN (April 1976). "Specific release of the thioesterase component of the fatty acid synthetase multienzyme complex by limited trypsinization". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1184–1188. Bibcode:1976PNAS...73.1184S. doi:10.1073/pnas.73.4.1184. PMC 430225. PMID 1063400.
Smith S, Witkowski A, Joshi AK (July 2003). "Structural and functional organization of the animal fatty acid synthase". Progress in Lipid Research. 42 (4): 289–317. doi:10.1016/S0163-7827(02)00067-X. PMID 12689621.
Jenke-Kodama H, Sandmann A, Müller R, Dittmann E (October 2005). "Evolutionary implications of bacterial polyketide synthases". Molecular Biology and Evolution. 22 (10): 2027–2039. doi:10.1093/molbev/msi193. PMID 15958783.
Fulmer T (March 2009). "Not so FAS". Science-Business EXchange. 2 (11): 430. doi:10.1038/scibx.2009.430.
Chirala SS, Jayakumar A, Gu ZW, Wakil SJ (March 2001). "Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer". Proceedings of the National Academy of Sciences of the United States of America. 98 (6): 3104–3108. Bibcode:2001PNAS...98.3104C. doi:10.1073/pnas.051635998. PMC 30614. PMID 11248039.
Smith S (December 1994). "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes". FASEB Journal. 8 (15): 1248–1259. doi:10.1096/fasebj.8.15.8001737. PMID 8001737. S2CID 22853095.
Stoops JK, Wakil SJ (May 1981). "Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits". Journal of Biological Chemistry. 256 (10): 5128–5133. doi:10.1016/S0021-9258(19)69376-2. PMID 6112225.
Stoops JK, Wakil SJ (March 1982). "Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the beta-ketoacyl synthetase site and their role in its cold inactivation". Journal of Biological Chemistry. 257 (6): 3230–3235. doi:10.1016/S0021-9258(19)81100-6. PMID 7061475.
Joshi AK, Rangan VS, Smith S (February 1998). "Differential affinity labeling of the two subunits of the homodimeric animal fatty acid synthase allows isolation of heterodimers consisting of subunits that have been independently modified". Journal of Biological Chemistry. 273 (9): 4937–4943. doi:10.1074/jbc.273.9.4937. PMID 9478938.
Rangan VS, Joshi AK, Smith S (September 2001). "Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro". Biochemistry. 40 (36): 10792–18799. doi:10.1021/bi015535z. PMID 11535054.
Witkowski A, Joshi AK, Rangan VS, Falick AM, Witkowska HE, Smith S (April 1999). "Dibromopropanone cross-linking of the phosphopantetheine and active-site cysteine thiols of the animal fatty acid synthase can occur both inter- and intrasubunit. Reevaluation of the side-by-side, antiparallel subunit model". Journal of Biological Chemistry. 274 (17): 11557–11563. doi:10.1074/jbc.274.17.11557. PMID 10206962.
Joshi AK, Rangan VS, Witkowski A, Smith S (February 2003). "Engineering of an active animal fatty acid synthase dimer with only one competent subunit". Chemistry and Biology. 10 (2): 169–173. doi:10.1016/S1074-5521(03)00023-1. PMID 12618189.
Asturias FJ, Chadick JZ, Cheung IK, Stark H, Witkowski A, Joshi AK, Smith S (March 2005). "Structure and molecular organization of mammalian fatty acid synthase". Nature Structural and Molecular Biology. 12 (3): 225–232. doi:10.1038/nsmb899. PMID 15711565. S2CID 6132878.
Maier T, Leibundgut M, Ban N (September 2008). "The crystal structure of a mammalian fatty acid synthase". Science. 321 (5894): 1315–1322. Bibcode:2008Sci...321.1315M. doi:10.1126/science.1161269. PMID 18772430. S2CID 3168991.
Lomakin IB, Xiong Y, Steitz TA (April 2007). "The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together". Cell. 129 (2): 319–332. doi:10.1016/j.cell.2007.03.013. PMID 17448991. S2CID 8209424.
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W (May 2010). "Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy". Proceedings of the National Academy of Sciences of the United States of America. 107 (20): 9164–9169. Bibcode:2010PNAS..107.9164G. doi:10.1073/pnas.0913547107. PMC 2889056. PMID 20231485.
Anselmi C, Grininger M, Gipson P, Faraldo-Gómez JD (September 2010). "Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase". Journal of the American Chemical Society. 132 (35): 12357–12364. doi:10.1021/ja103354w. PMID 20704262.
Paulauskis JD, Sul HS (January 1989). "Hormonal regulation of mouse fatty acid synthase gene transcription in liver". Journal of Biological Chemistry. 264 (1): 574–577. doi:10.1016/S0021-9258(17)31298-X. PMID 2535847.
Latasa MJ, Griffin MJ, Moon YS, Kang C, Sul HS (August 2003). "Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals". Molecular and Cellular Biology. 23 (16): 5896–5907. doi:10.1128/MCB.23.16.5896-5907.2003. PMC 166350. PMID 12897158.
Griffin MJ, Wong RH, Pandya N, Sul HS (February 2007). "Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter". Journal of Biological Chemistry. 282 (8): 5453–5467. doi:10.1074/jbc.M610566200. PMID 17197698.
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N (May 2001). "Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter". Molecular and Cellular Biology. 21 (9): 2991–3000. doi:10.1128/MCB.21.9.2991-3000.2001. PMC 86928. PMID 11287605.
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ (November 2000). "Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta". Genes & Development. 14 (22): 2819–2830. doi:10.1101/gad.844900. PMC 317055. PMID 11090130.
Na M, Jang J, Min BS, Lee SJ, Lee MS, Kim BY, Oh WK, Ahn JS (September 2006). "Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma". Bioorganic & Medicinal Chemistry Letters. 16 (18): 4738–4742. doi:10.1016/j.bmcl.2006.07.018. PMID 16870425.
Baron A, Migita T, Tang D, Loda M (January 2004). "Fatty acid synthase: a metabolic oncogene in prostate cancer?". Journal of Cellular Biochemistry. 91 (1): 47–53. doi:10.1002/jcb.10708. PMID 14689581. S2CID 26175683.
Gansler TS, Hardman W, Hunt DA, Schaffel S, Hennigar RA (June 1997). "Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival". Human Pathology. 28 (6): 686–692. doi:10.1016/S0046-8177(97)90177-5. PMID 9191002.
Ezzeddini R, Taghikhani M, Somi MH, Samadi N, Rasaee, MJ (May 2019). "Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma". Life Sciences. 224: 169–176. doi:10.1016/j.lfs.2019.03.056. PMID 30914315. S2CID 85532042.
Lu T, Schubert C, Cummings MD, Bignan G, Connolly PJ, Smans K, Ludovici D, Parker MH, Meyer C, Rocaboy C, Alexander R, Grasberger B, De Breucker S, Esser N, Fraiponts E, Gilissen R, Janssens B, Peeters D, Van Nuffel L, Vermeulen P, Bischoff J, Meerpoel L (May 2018). "Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy". Bioorganic & Medicinal Chemistry Letters. 28 (12): 2159–2164. doi:10.1016/j.bmcl.2018.05.014. PMID 29779975. S2CID 29159508.
Hardwicke MA, Rendina AR, Williams SP, Moore ML, Wang L, Krueger JA, Plant RN, Totoritis RD, Zhang G, Briand J, Burkhart WA, Brown KK, Parrish CA (September 2014). "A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site". Nature Chemical Biology. 10 (9): 774–779. doi:10.1038/nchembio.1603. PMID 25086508.
Vander Heiden MG, DeBerardinis RJ (February 2017). "Understanding the Intersections between Metabolism and Cancer Biology". Cell. 168 (4): 657–669. doi:10.1016/j.cell.2016.12.039. PMC 5329766. PMID 28187287.
Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF (August 2009). "Identification of a physiologically relevant endogenous ligand for PPARalpha in liver". Cell. 138 (3): 476–488. doi:10.1016/j.cell.2009.05.036. PMC 2725194. PMID 19646743.
Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C (March 2011). "Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes". Proceedings of the National Academy of Sciences of the United States of America. 108 (13): 5378–5383. Bibcode:2011PNAS..108.5378W. doi:10.1073/pnas.1002588108. PMC 3069196. PMID 21389266.
Flavin R, Peluso S, Nguyen PL, Loda M (April 2010). "Fatty acid synthase as a potential therapeutic target in cancer". Future Oncology. 6 (4): 551–562. doi:10.2217/fon.10.11. PMC 3197858. PMID 20373869.
Richardson RD, Ma G, Oyola Y, Zancanella M, Knowles LM, Cieplak P, Romo D, Smith JW (September 2008). "Synthesis of novel beta-lactone inhibitors of fatty acid synthase". Journal of Medicinal Chemistry. 51 (17): 5285–5296. doi:10.1021/jm800321h. PMC 3172131. PMID 18710210.
Eggert SL, Huyck KL, Somasundaram P, Kavalla R, Stewart EA, Lu AT, Painter JN, Montgomery GW, Medland SE, Nyholt DR, Treloar SA, Zondervan KT, Heath AC, Madden PA, Rose L, Buring JE, Ridker PM, Chasman DI, Martin NG, Cantor RM, Morton CC (2012). "Genome-wide linkage and association analyses implicate FASN in predisposition to uterine leiomyomata". American Journal of Human Genetics. 91 (4): 621–628. doi:10.1016/j.ajhg.2012.08.009. PMC 3484658. PMID 23040493.

harvard.edu

ui.adsabs.harvard.edu

Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ (Oct 1995). "Human fatty acid synthase: properties and molecular cloning". Proceedings of the National Academy of Sciences of the United States of America. 92 (19): 8695–8699. Bibcode:1995PNAS...92.8695J. doi:10.1073/pnas.92.19.8695. PMC 41033. PMID 7567999.
Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
Alberts AW, Strauss AW, Hennessy S, Vagelos PR (October 1975). "Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes". Proceedings of the National Academy of Sciences of the United States of America. 72 (10): 3956–3960. Bibcode:1975PNAS...72.3956A. doi:10.1073/pnas.72.10.3956. PMC 433116. PMID 1060077.
Stoops JK, Arslanian MJ, Oh YH, Aune KC, Vanaman TC, Wakil SJ (May 1975). "Presence of two polypeptide chains comprising fatty acid synthetase". Proceedings of the National Academy of Sciences of the United States of America. 72 (5): 1940–1944. Bibcode:1975PNAS...72.1940S. doi:10.1073/pnas.72.5.1940. PMC 432664. PMID 1098047.
Smith S, Agradi E, Libertini L, Dileepan KN (April 1976). "Specific release of the thioesterase component of the fatty acid synthetase multienzyme complex by limited trypsinization". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1184–1188. Bibcode:1976PNAS...73.1184S. doi:10.1073/pnas.73.4.1184. PMC 430225. PMID 1063400.
Chirala SS, Jayakumar A, Gu ZW, Wakil SJ (March 2001). "Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer". Proceedings of the National Academy of Sciences of the United States of America. 98 (6): 3104–3108. Bibcode:2001PNAS...98.3104C. doi:10.1073/pnas.051635998. PMC 30614. PMID 11248039.
Maier T, Leibundgut M, Ban N (September 2008). "The crystal structure of a mammalian fatty acid synthase". Science. 321 (5894): 1315–1322. Bibcode:2008Sci...321.1315M. doi:10.1126/science.1161269. PMID 18772430. S2CID 3168991.
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W (May 2010). "Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy". Proceedings of the National Academy of Sciences of the United States of America. 107 (20): 9164–9169. Bibcode:2010PNAS..107.9164G. doi:10.1073/pnas.0913547107. PMC 2889056. PMID 20231485.
Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C (March 2011). "Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes". Proceedings of the National Academy of Sciences of the United States of America. 108 (13): 5378–5383. Bibcode:2011PNAS..108.5378W. doi:10.1073/pnas.1002588108. PMC 3069196. PMID 21389266.

latrobe.edu.au

opal.latrobe.edu.au

Sgro CD (2009-01-01). An investigation into the interdomain region of Caenorhabditis elegans fatty acid synthase and its implications as a drug target (thesis thesis). La Trobe.

nih.gov

pubmed.ncbi.nlm.nih.gov

Paiva P, Medina FE, Viegas M, Ferreira P, Neves RP, Sousa JP, Ramos MJ, Fernandes PA (2021-08-11). "Animal Fatty Acid Synthase: A Chemical Nanofactory". Chemical Reviews. 121 (15): 9502–9553. doi:10.1021/acs.chemrev.1c00147. ISSN 0009-2665. PMID 34156235. S2CID 235595027.
Jayakumar A, Chirala SS, Chinault AC, Baldini A, Abu-Elheiga L, Wakil SJ (February 1995). "Isolation and chromosomal mapping of genomic clones encoding the human fatty acid synthase gene". Genomics. 23 (2): 420–424. doi:10.1006/geno.1994.1518. PMID 7835891.
Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ (Oct 1995). "Human fatty acid synthase: properties and molecular cloning". Proceedings of the National Academy of Sciences of the United States of America. 92 (19): 8695–8699. Bibcode:1995PNAS...92.8695J. doi:10.1073/pnas.92.19.8695. PMC 41033. PMID 7567999.
Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
Alberts AW, Strauss AW, Hennessy S, Vagelos PR (October 1975). "Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes". Proceedings of the National Academy of Sciences of the United States of America. 72 (10): 3956–3960. Bibcode:1975PNAS...72.3956A. doi:10.1073/pnas.72.10.3956. PMC 433116. PMID 1060077.
Stoops JK, Arslanian MJ, Oh YH, Aune KC, Vanaman TC, Wakil SJ (May 1975). "Presence of two polypeptide chains comprising fatty acid synthetase". Proceedings of the National Academy of Sciences of the United States of America. 72 (5): 1940–1944. Bibcode:1975PNAS...72.1940S. doi:10.1073/pnas.72.5.1940. PMC 432664. PMID 1098047.
Smith S, Agradi E, Libertini L, Dileepan KN (April 1976). "Specific release of the thioesterase component of the fatty acid synthetase multienzyme complex by limited trypsinization". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1184–1188. Bibcode:1976PNAS...73.1184S. doi:10.1073/pnas.73.4.1184. PMC 430225. PMID 1063400.
Smith S, Witkowski A, Joshi AK (July 2003). "Structural and functional organization of the animal fatty acid synthase". Progress in Lipid Research. 42 (4): 289–317. doi:10.1016/S0163-7827(02)00067-X. PMID 12689621.
Jenke-Kodama H, Sandmann A, Müller R, Dittmann E (October 2005). "Evolutionary implications of bacterial polyketide synthases". Molecular Biology and Evolution. 22 (10): 2027–2039. doi:10.1093/molbev/msi193. PMID 15958783.
Chirala SS, Jayakumar A, Gu ZW, Wakil SJ (March 2001). "Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer". Proceedings of the National Academy of Sciences of the United States of America. 98 (6): 3104–3108. Bibcode:2001PNAS...98.3104C. doi:10.1073/pnas.051635998. PMC 30614. PMID 11248039.
Smith S (December 1994). "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes". FASEB Journal. 8 (15): 1248–1259. doi:10.1096/fasebj.8.15.8001737. PMID 8001737. S2CID 22853095.
Stoops JK, Wakil SJ (May 1981). "Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits". Journal of Biological Chemistry. 256 (10): 5128–5133. doi:10.1016/S0021-9258(19)69376-2. PMID 6112225.
Stoops JK, Wakil SJ (March 1982). "Animal fatty acid synthetase. Identification of the residues comprising the novel arrangement of the beta-ketoacyl synthetase site and their role in its cold inactivation". Journal of Biological Chemistry. 257 (6): 3230–3235. doi:10.1016/S0021-9258(19)81100-6. PMID 7061475.
Joshi AK, Rangan VS, Smith S (February 1998). "Differential affinity labeling of the two subunits of the homodimeric animal fatty acid synthase allows isolation of heterodimers consisting of subunits that have been independently modified". Journal of Biological Chemistry. 273 (9): 4937–4943. doi:10.1074/jbc.273.9.4937. PMID 9478938.
Rangan VS, Joshi AK, Smith S (September 2001). "Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro". Biochemistry. 40 (36): 10792–18799. doi:10.1021/bi015535z. PMID 11535054.
Witkowski A, Joshi AK, Rangan VS, Falick AM, Witkowska HE, Smith S (April 1999). "Dibromopropanone cross-linking of the phosphopantetheine and active-site cysteine thiols of the animal fatty acid synthase can occur both inter- and intrasubunit. Reevaluation of the side-by-side, antiparallel subunit model". Journal of Biological Chemistry. 274 (17): 11557–11563. doi:10.1074/jbc.274.17.11557. PMID 10206962.
Joshi AK, Rangan VS, Witkowski A, Smith S (February 2003). "Engineering of an active animal fatty acid synthase dimer with only one competent subunit". Chemistry and Biology. 10 (2): 169–173. doi:10.1016/S1074-5521(03)00023-1. PMID 12618189.
Asturias FJ, Chadick JZ, Cheung IK, Stark H, Witkowski A, Joshi AK, Smith S (March 2005). "Structure and molecular organization of mammalian fatty acid synthase". Nature Structural and Molecular Biology. 12 (3): 225–232. doi:10.1038/nsmb899. PMID 15711565. S2CID 6132878.
Maier T, Leibundgut M, Ban N (September 2008). "The crystal structure of a mammalian fatty acid synthase". Science. 321 (5894): 1315–1322. Bibcode:2008Sci...321.1315M. doi:10.1126/science.1161269. PMID 18772430. S2CID 3168991.
Lomakin IB, Xiong Y, Steitz TA (April 2007). "The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together". Cell. 129 (2): 319–332. doi:10.1016/j.cell.2007.03.013. PMID 17448991. S2CID 8209424.
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W (May 2010). "Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy". Proceedings of the National Academy of Sciences of the United States of America. 107 (20): 9164–9169. Bibcode:2010PNAS..107.9164G. doi:10.1073/pnas.0913547107. PMC 2889056. PMID 20231485.
Anselmi C, Grininger M, Gipson P, Faraldo-Gómez JD (September 2010). "Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase". Journal of the American Chemical Society. 132 (35): 12357–12364. doi:10.1021/ja103354w. PMID 20704262.
Paulauskis JD, Sul HS (January 1989). "Hormonal regulation of mouse fatty acid synthase gene transcription in liver". Journal of Biological Chemistry. 264 (1): 574–577. doi:10.1016/S0021-9258(17)31298-X. PMID 2535847.
Latasa MJ, Griffin MJ, Moon YS, Kang C, Sul HS (August 2003). "Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals". Molecular and Cellular Biology. 23 (16): 5896–5907. doi:10.1128/MCB.23.16.5896-5907.2003. PMC 166350. PMID 12897158.
Griffin MJ, Wong RH, Pandya N, Sul HS (February 2007). "Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter". Journal of Biological Chemistry. 282 (8): 5453–5467. doi:10.1074/jbc.M610566200. PMID 17197698.
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N (May 2001). "Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter". Molecular and Cellular Biology. 21 (9): 2991–3000. doi:10.1128/MCB.21.9.2991-3000.2001. PMC 86928. PMID 11287605.
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ (November 2000). "Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta". Genes & Development. 14 (22): 2819–2830. doi:10.1101/gad.844900. PMC 317055. PMID 11090130.
Na M, Jang J, Min BS, Lee SJ, Lee MS, Kim BY, Oh WK, Ahn JS (September 2006). "Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma". Bioorganic & Medicinal Chemistry Letters. 16 (18): 4738–4742. doi:10.1016/j.bmcl.2006.07.018. PMID 16870425.
Baron A, Migita T, Tang D, Loda M (January 2004). "Fatty acid synthase: a metabolic oncogene in prostate cancer?". Journal of Cellular Biochemistry. 91 (1): 47–53. doi:10.1002/jcb.10708. PMID 14689581. S2CID 26175683.
Hunt DA, Lane HM, Zygmont ME, Dervan PA, Hennigar RA (2007). "MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines". Anticancer Research. 27 (1A): 27–34. PMID 17352212.
Gansler TS, Hardman W, Hunt DA, Schaffel S, Hennigar RA (June 1997). "Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival". Human Pathology. 28 (6): 686–692. doi:10.1016/S0046-8177(97)90177-5. PMID 9191002.
Ezzeddini R, Taghikhani M, Somi MH, Samadi N, Rasaee, MJ (May 2019). "Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma". Life Sciences. 224: 169–176. doi:10.1016/j.lfs.2019.03.056. PMID 30914315. S2CID 85532042.
Lu T, Schubert C, Cummings MD, Bignan G, Connolly PJ, Smans K, Ludovici D, Parker MH, Meyer C, Rocaboy C, Alexander R, Grasberger B, De Breucker S, Esser N, Fraiponts E, Gilissen R, Janssens B, Peeters D, Van Nuffel L, Vermeulen P, Bischoff J, Meerpoel L (May 2018). "Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy". Bioorganic & Medicinal Chemistry Letters. 28 (12): 2159–2164. doi:10.1016/j.bmcl.2018.05.014. PMID 29779975. S2CID 29159508.
Hardwicke MA, Rendina AR, Williams SP, Moore ML, Wang L, Krueger JA, Plant RN, Totoritis RD, Zhang G, Briand J, Burkhart WA, Brown KK, Parrish CA (September 2014). "A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site". Nature Chemical Biology. 10 (9): 774–779. doi:10.1038/nchembio.1603. PMID 25086508.
Vander Heiden MG, DeBerardinis RJ (February 2017). "Understanding the Intersections between Metabolism and Cancer Biology". Cell. 168 (4): 657–669. doi:10.1016/j.cell.2016.12.039. PMC 5329766. PMID 28187287.
Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF (August 2009). "Identification of a physiologically relevant endogenous ligand for PPARalpha in liver". Cell. 138 (3): 476–488. doi:10.1016/j.cell.2009.05.036. PMC 2725194. PMID 19646743.
Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C (March 2011). "Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes". Proceedings of the National Academy of Sciences of the United States of America. 108 (13): 5378–5383. Bibcode:2011PNAS..108.5378W. doi:10.1073/pnas.1002588108. PMC 3069196. PMID 21389266.
Flavin R, Peluso S, Nguyen PL, Loda M (April 2010). "Fatty acid synthase as a potential therapeutic target in cancer". Future Oncology. 6 (4): 551–562. doi:10.2217/fon.10.11. PMC 3197858. PMID 20373869.
Richardson RD, Ma G, Oyola Y, Zancanella M, Knowles LM, Cieplak P, Romo D, Smith JW (September 2008). "Synthesis of novel beta-lactone inhibitors of fatty acid synthase". Journal of Medicinal Chemistry. 51 (17): 5285–5296. doi:10.1021/jm800321h. PMC 3172131. PMID 18710210.
Eggert SL, Huyck KL, Somasundaram P, Kavalla R, Stewart EA, Lu AT, Painter JN, Montgomery GW, Medland SE, Nyholt DR, Treloar SA, Zondervan KT, Heath AC, Madden PA, Rose L, Buring JE, Ridker PM, Chasman DI, Martin NG, Cantor RM, Morton CC (2012). "Genome-wide linkage and association analyses implicate FASN in predisposition to uterine leiomyomata". American Journal of Human Genetics. 91 (4): 621–628. doi:10.1016/j.ajhg.2012.08.009. PMC 3484658. PMID 23040493.

ncbi.nlm.nih.gov

Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ (Oct 1995). "Human fatty acid synthase: properties and molecular cloning". Proceedings of the National Academy of Sciences of the United States of America. 92 (19): 8695–8699. Bibcode:1995PNAS...92.8695J. doi:10.1073/pnas.92.19.8695. PMC 41033. PMID 7567999.
Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–98. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
"Entrez Gene: FASN fatty acid synthase".
Alberts AW, Strauss AW, Hennessy S, Vagelos PR (October 1975). "Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes". Proceedings of the National Academy of Sciences of the United States of America. 72 (10): 3956–3960. Bibcode:1975PNAS...72.3956A. doi:10.1073/pnas.72.10.3956. PMC 433116. PMID 1060077.
Stoops JK, Arslanian MJ, Oh YH, Aune KC, Vanaman TC, Wakil SJ (May 1975). "Presence of two polypeptide chains comprising fatty acid synthetase". Proceedings of the National Academy of Sciences of the United States of America. 72 (5): 1940–1944. Bibcode:1975PNAS...72.1940S. doi:10.1073/pnas.72.5.1940. PMC 432664. PMID 1098047.
Smith S, Agradi E, Libertini L, Dileepan KN (April 1976). "Specific release of the thioesterase component of the fatty acid synthetase multienzyme complex by limited trypsinization". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1184–1188. Bibcode:1976PNAS...73.1184S. doi:10.1073/pnas.73.4.1184. PMC 430225. PMID 1063400.
Chirala SS, Jayakumar A, Gu ZW, Wakil SJ (March 2001). "Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer". Proceedings of the National Academy of Sciences of the United States of America. 98 (6): 3104–3108. Bibcode:2001PNAS...98.3104C. doi:10.1073/pnas.051635998. PMC 30614. PMID 11248039.
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W (May 2010). "Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy". Proceedings of the National Academy of Sciences of the United States of America. 107 (20): 9164–9169. Bibcode:2010PNAS..107.9164G. doi:10.1073/pnas.0913547107. PMC 2889056. PMID 20231485.
Latasa MJ, Griffin MJ, Moon YS, Kang C, Sul HS (August 2003). "Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals". Molecular and Cellular Biology. 23 (16): 5896–5907. doi:10.1128/MCB.23.16.5896-5907.2003. PMC 166350. PMID 12897158.
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N (May 2001). "Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter". Molecular and Cellular Biology. 21 (9): 2991–3000. doi:10.1128/MCB.21.9.2991-3000.2001. PMC 86928. PMID 11287605.
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ (November 2000). "Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta". Genes & Development. 14 (22): 2819–2830. doi:10.1101/gad.844900. PMC 317055. PMID 11090130.
Vander Heiden MG, DeBerardinis RJ (February 2017). "Understanding the Intersections between Metabolism and Cancer Biology". Cell. 168 (4): 657–669. doi:10.1016/j.cell.2016.12.039. PMC 5329766. PMID 28187287.
Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF (August 2009). "Identification of a physiologically relevant endogenous ligand for PPARalpha in liver". Cell. 138 (3): 476–488. doi:10.1016/j.cell.2009.05.036. PMC 2725194. PMID 19646743.
Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C (March 2011). "Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes". Proceedings of the National Academy of Sciences of the United States of America. 108 (13): 5378–5383. Bibcode:2011PNAS..108.5378W. doi:10.1073/pnas.1002588108. PMC 3069196. PMID 21389266.
Flavin R, Peluso S, Nguyen PL, Loda M (April 2010). "Fatty acid synthase as a potential therapeutic target in cancer". Future Oncology. 6 (4): 551–562. doi:10.2217/fon.10.11. PMC 3197858. PMID 20373869.
Richardson RD, Ma G, Oyola Y, Zancanella M, Knowles LM, Cieplak P, Romo D, Smith JW (September 2008). "Synthesis of novel beta-lactone inhibitors of fatty acid synthase". Journal of Medicinal Chemistry. 51 (17): 5285–5296. doi:10.1021/jm800321h. PMC 3172131. PMID 18710210.
Eggert SL, Huyck KL, Somasundaram P, Kavalla R, Stewart EA, Lu AT, Painter JN, Montgomery GW, Medland SE, Nyholt DR, Treloar SA, Zondervan KT, Heath AC, Madden PA, Rose L, Buring JE, Ridker PM, Chasman DI, Martin NG, Cantor RM, Morton CC (2012). "Genome-wide linkage and association analyses implicate FASN in predisposition to uterine leiomyomata". American Journal of Human Genetics. 91 (4): 621–628. doi:10.1016/j.ajhg.2012.08.009. PMC 3484658. PMID 23040493.

oncotherapynetwork.com

"First Human Study Taking Place With Fatty Acid Synthase Inhibitor". oncotherapynetwork.com. April 7, 2017. Archived from the original on April 15, 2019. Retrieved June 4, 2018.

sciencedirect.com

Ezzeddini R, Taghikhani M, Somi MH, Samadi N, Rasaee, MJ (May 2019). "Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma". Life Sciences. 224: 169–176. doi:10.1016/j.lfs.2019.03.056. PMID 30914315. S2CID 85532042.

semanticscholar.org

api.semanticscholar.org

Paiva P, Medina FE, Viegas M, Ferreira P, Neves RP, Sousa JP, Ramos MJ, Fernandes PA (2021-08-11). "Animal Fatty Acid Synthase: A Chemical Nanofactory". Chemical Reviews. 121 (15): 9502–9553. doi:10.1021/acs.chemrev.1c00147. ISSN 0009-2665. PMID 34156235. S2CID 235595027.
Smith S (December 1994). "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes". FASEB Journal. 8 (15): 1248–1259. doi:10.1096/fasebj.8.15.8001737. PMID 8001737. S2CID 22853095.
Asturias FJ, Chadick JZ, Cheung IK, Stark H, Witkowski A, Joshi AK, Smith S (March 2005). "Structure and molecular organization of mammalian fatty acid synthase". Nature Structural and Molecular Biology. 12 (3): 225–232. doi:10.1038/nsmb899. PMID 15711565. S2CID 6132878.
Maier T, Leibundgut M, Ban N (September 2008). "The crystal structure of a mammalian fatty acid synthase". Science. 321 (5894): 1315–1322. Bibcode:2008Sci...321.1315M. doi:10.1126/science.1161269. PMID 18772430. S2CID 3168991.
Lomakin IB, Xiong Y, Steitz TA (April 2007). "The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together". Cell. 129 (2): 319–332. doi:10.1016/j.cell.2007.03.013. PMID 17448991. S2CID 8209424.
Baron A, Migita T, Tang D, Loda M (January 2004). "Fatty acid synthase: a metabolic oncogene in prostate cancer?". Journal of Cellular Biochemistry. 91 (1): 47–53. doi:10.1002/jcb.10708. PMID 14689581. S2CID 26175683.
Ezzeddini R, Taghikhani M, Somi MH, Samadi N, Rasaee, MJ (May 2019). "Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma". Life Sciences. 224: 169–176. doi:10.1016/j.lfs.2019.03.056. PMID 30914315. S2CID 85532042.
Lu T, Schubert C, Cummings MD, Bignan G, Connolly PJ, Smans K, Ludovici D, Parker MH, Meyer C, Rocaboy C, Alexander R, Grasberger B, De Breucker S, Esser N, Fraiponts E, Gilissen R, Janssens B, Peeters D, Van Nuffel L, Vermeulen P, Bischoff J, Meerpoel L (May 2018). "Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy". Bioorganic & Medicinal Chemistry Letters. 28 (12): 2159–2164. doi:10.1016/j.bmcl.2018.05.014. PMID 29779975. S2CID 29159508.

web.archive.org

"First Human Study Taking Place With Fatty Acid Synthase Inhibitor". oncotherapynetwork.com. April 7, 2017. Archived from the original on April 15, 2019. Retrieved June 4, 2018.

worldcat.org

Paiva P, Medina FE, Viegas M, Ferreira P, Neves RP, Sousa JP, Ramos MJ, Fernandes PA (2021-08-11). "Animal Fatty Acid Synthase: A Chemical Nanofactory". Chemical Reviews. 121 (15): 9502–9553. doi:10.1021/acs.chemrev.1c00147. ISSN 0009-2665. PMID 34156235. S2CID 235595027.