Free fatty acid receptor 3 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Free fatty acid receptor 3" in English language version.

refsWebsite

Global rank English rank

79nih.gov

4^th place

52doi.org

2^nd place

22semanticscholar.org

11^th place

8^th place

6harvard.edu

18^th place

17^th place

3handle.net

102^nd place

76^th place

2ensembl.org

1,626^th place

1,007^th place

1figshare.com

5,893^rd place

3,320^th place

1ucl.ac.uk

1,306^th place

885^th place

doi.org

Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF (October 1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochemical and Biophysical Research Communications. 239 (2): 543–547. doi:10.1006/bbrc.1997.7513. PMID 9344866.
Karmokar PF, Moniri NH (December 2022). "Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells". Biochemical Pharmacology. 206: 115328. doi:10.1016/j.bcp.2022.115328. PMID 36309079. S2CID 253174629.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, et al. (March 2003). "The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids". The Journal of Biological Chemistry. 278 (13): 11303–11311. doi:10.1074/jbc.M211495200. PMID 12496284.
Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, et al. (January 2018). "20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1". Nature Communications. 9 (1): 177. Bibcode:2018NatCo...9..177T. doi:10.1038/s41467-017-02539-4. PMC 5766607. PMID 29330456.
Grundmann M, Bender E, Schamberger J, Eitner F (February 2021). "Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators". International Journal of Molecular Sciences. 22 (4): 1763. doi:10.3390/ijms22041763. PMC 7916689. PMID 33578942.
Offermanns S (March 2017). "Hydroxy-Carboxylic Acid Receptor Actions in Metabolism". Trends in Endocrinology and Metabolism. 28 (3): 227–236. doi:10.1016/j.tem.2016.11.007. PMID 28087125. S2CID 39660018.
Mishra SP, Karunakar P, Taraphder S, Yadav H (June 2020). "Free Fatty Acid Receptors 2 and 3 as Microbial Metabolite Sensors to Shape Host Health: Pharmacophysiological View". Biomedicines. 8 (6): 154. doi:10.3390/biomedicines8060154. PMC 7344995. PMID 32521775.
Secor JD, Fligor SC, Tsikis ST, Yu LJ, Puder M (2021). "Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease". Frontiers in Physiology. 12: 656441. doi:10.3389/fphys.2021.656441. PMC 8058363. PMID 33897464.
Ang Z, Xiong D, Wu M, Ding JL (January 2018). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". FASEB Journal. 32 (1): 289–303. doi:10.1096/fj.201700252RR. PMC 5731126. PMID 28883043.
Martin-Gallausiaux C, Marinelli L, Blottière HM, Larraufie P, Lapaque N (February 2021). "SCFA: mechanisms and functional importance in the gut". The Proceedings of the Nutrition Society. 80 (1): 37–49. doi:10.1017/S0029665120006916. PMID 32238208. S2CID 214772999.
Ang Z, Er JZ, Tan NS, Lu J, Liou YC, Grosse J, et al. (September 2016). "Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists". Scientific Reports. 6: 34145. Bibcode:2016NatSR...634145A. doi:10.1038/srep34145. PMC 5036191. PMID 27667443.
Carretta MD, Quiroga J, López R, Hidalgo MA, Burgos RA (2021). "Participation of Short-Chain Fatty Acids and Their Receptors in Gut Inflammation and Colon Cancer". Frontiers in Physiology. 12: 662739. doi:10.3389/fphys.2021.662739. PMC 8060628. PMID 33897470.
Tan JK, Macia L, Mackay CR (February 2023). "Dietary fiber and SCFAs in the regulation of mucosal immunity". The Journal of Allergy and Clinical Immunology. 151 (2): 361–370. doi:10.1016/j.jaci.2022.11.007. PMID 36543697. S2CID 254918066.
Ikeda T, Nishida A, Yamano M, Kimura I (November 2022). "Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases". Pharmacology & Therapeutics. 239: 108273. doi:10.1016/j.pharmthera.2022.108273. PMID 36057320. S2CID 251992642.
Obradovic M, Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart AJ, et al. (2021). "Leptin and Obesity: Role and Clinical Implication". Frontiers in Endocrinology. 12: 585887. doi:10.3389/fendo.2021.585887. PMC 8167040. PMID 34084149.
Navalón-Monllor V, Soriano-Romaní L, Silva M, de Las Hazas ML, Hernando-Quintana N, Suárez Diéguez T, et al. (August 2023). "Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms". Food & Function. 14 (16): 7317–7334. doi:10.1039/d3fo01257c. PMID 37470232. S2CID 259996464.
Shimizu H, Masujima Y, Ushiroda C, Mizushima R, Taira S, Ohue-Kitano R, et al. (November 2019). "Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3". Scientific Reports. 9 (1): 16574. Bibcode:2019NatSR...916574S. doi:10.1038/s41598-019-53242-x. PMC 6851370. PMID 31719611.
Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, et al. (March 2013). "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America. 110 (11): 4410–4415. Bibcode:2013PNAS..110.4410P. doi:10.1073/pnas.1215927110. PMC 3600440. PMID 23401498.
Ghislain J, Poitout V (March 2021). "Targeting lipid GPCRs to treat type 2 diabetes mellitus - progress and challenges". Nature Reviews. Endocrinology. 17 (3): 162–175. doi:10.1038/s41574-020-00459-w. PMID 33495605. S2CID 231695737.
Yuan G, Wen S, Zhong X, Yang X, Xie L, Wu X, et al. (2023). "Inulin alleviates offspring asthma by altering maternal intestinal microbiome composition to increase short-chain fatty acids". PLOS ONE. 18 (4): e0283105. Bibcode:2023PLoSO..1883105Y. doi:10.1371/journal.pone.0283105. PMC 10072493. PMID 37014871.
Kim YA, Keogh JB, Clifton PM (June 2018). "Probiotics, prebiotics, synbiotics and insulin sensitivity". Nutrition Research Reviews. 31 (1): 35–51. doi:10.1017/S095442241700018X. PMID 29037268.
Kimura I, Ichimura A, Ohue-Kitano R, Igarashi M (January 2020). "Free Fatty Acid Receptors in Health and Disease". Physiological Reviews. 100 (1): 171–210. doi:10.1152/physrev.00041.2018. PMID 31487233. S2CID 201845937.
Loona DP, Das B, Kaur R, Kumar R, Yadav AK (2023). "Free Fatty Acid Receptors (FFARs): Emerging Therapeutic Targets for the Management of Diabetes Mellitus". Current Medicinal Chemistry. 30 (30): 3404–3440. doi:10.2174/0929867329666220927113614. PMID 36173072. S2CID 252598831.
Kuwahara A, Kuwahara Y, Inui T, Marunaka Y (March 2018). "Regulation of Ion Transport in the Intestine by Free Fatty Acid Receptor 2 and 3: Possible Involvement of the Diffuse Chemosensory System". International Journal of Molecular Sciences. 19 (3): 735. doi:10.3390/ijms19030735. PMC 5877596. PMID 29510573.
Zhang D, Jian YP, Zhang YN, Li Y, Gu LT, Sun HH, et al. (August 2023). "Short-chain fatty acids in diseases". Cell Communication and Signaling. 21 (1): 212. doi:10.1186/s12964-023-01219-9. PMC 10436623. PMID 37596634.
Won YJ, Lu VB, Puhl HL, Ikeda SR (December 2013). "β-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3". The Journal of Neuroscience. 33 (49): 19314–19325. doi:10.1523/JNEUROSCI.3102-13.2013. PMC 3850046. PMID 24305827.
Christiansen CB, Gabe MB, Svendsen B, Dragsted LO, Rosenkilde MM, Holst JJ (July 2018). "The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon". American Journal of Physiology. Gastrointestinal and Liver Physiology. 315 (1): G53 – G65. doi:10.1152/ajpgi.00346.2017. PMID 29494208. S2CID 3633401.
Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, et al. (2020). "AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition". Therapeutic Advances in Medical Oncology. 12: 1758835920913432. doi:10.1177/1758835920913432. PMC 7517987. PMID 33014144.
Hoyles L, Snelling T, Umlai UK, Nicholson JK, Carding SR, Glen RC, et al. (March 2018). "Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier". Microbiome. 6 (1): 55. doi:10.1186/s40168-018-0439-y. PMC 5863458. PMID 29562936.
Teyani R, Moniri NH (December 2023). "Gut feelings in the islets: The role of the gut microbiome and the FFA2 and FFA3 receptors for short chain fatty acids on β-cell function and metabolic regulation". British Journal of Pharmacology. 180 (24): 3113–3129. doi:10.1111/bph.16225. PMID 37620991. S2CID 261121846.
Al Mahri S, Malik SS, Al Ibrahim M, Haji E, Dairi G, Mohammad S (February 2022). "Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook". Cells. 11 (4): 750. doi:10.3390/cells11040750. PMC 8870169. PMID 35203397.
Voltolini C, Battersby S, Etherington SL, Petraglia F, Norman JE, Jabbour HN (January 2012). "A novel antiinflammatory role for the short-chain fatty acids in human labor". Endocrinology. 153 (1): 395–403. doi:10.1210/en.2011-1457. hdl:20.500.11820/7035e8fd-062a-491a-9943-f20ad03844dd. PMID 22186417. S2CID 34431654.
Zamarbide M, Martinez-Pinilla E, Gil-Bea F, Yanagisawa M, Franco R, Perez-Mediavilla A (March 2022). "Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP_swe Alzheimer's Disease Mouse Model". International Journal of Molecular Sciences. 23 (7): 3533. doi:10.3390/ijms23073533. PMC 8999053. PMID 35408893.
Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, et al. (May 2011). "Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 8030–8035. Bibcode:2011PNAS..108.8030K. doi:10.1073/pnas.1016088108. PMC 3093469. PMID 21518883.
Cox MA, Jackson J, Stanton M, Rojas-Triana A, Bober L, Laverty M, et al. (November 2009). "Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines". World Journal of Gastroenterology. 15 (44): 5549–5557. doi:10.3748/wjg.15.5549. PMC 2785057. PMID 19938193.
Miyasato S, Iwata K, Mura R, Nakamura S, Yanagida K, Shindou H, et al. (January 2023). "Constitutively active GPR43 is crucial for proper leukocyte differentiation". FASEB Journal. 37 (1): e22676. doi:10.1096/fj.202201591R. PMID 36468834. S2CID 254244683.
Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, et al. (July 2003). "Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation". The Journal of Biological Chemistry. 278 (28): 25481–25489. doi:10.1074/jbc.M301403200. PMID 12711604.
Yonezawa T, Kobayashi Y, Obara Y (January 2007). "Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line". Cellular Signalling. 19 (1): 185–193. doi:10.1016/j.cellsig.2006.06.004. PMID 16887331.
Al Mahri S, Al Ghamdi A, Akiel M, Al Aujan M, Mohammad S, Aziz MA (May 2020). "Free fatty acids receptors 2 and 3 control cell proliferation by regulating cellular glucose uptake". World Journal of Gastrointestinal Oncology. 12 (5): 514–525. doi:10.4251/wjgo.v12.i5.514. PMC 7235185. PMID 32461783.
de Vos WM, Tilg H, Van Hul M, Cani PD (May 2022). "Gut microbiome and health: mechanistic insights". Gut. 71 (5): 1020–1032. doi:10.1136/gutjnl-2021-326789. PMC 8995832. PMID 35105664.
Gabriel FC, Fantuzzi G (December 2019). "The association of short-chain fatty acids and leptin metabolism: a systematic review". Nutrition Research. 72: 18–35. doi:10.1016/j.nutres.2019.08.006. PMID 31669116. S2CID 155928278.
Pluznick JL (April 2017). "Microbial Short-Chain Fatty Acids and Blood Pressure Regulation". Current Hypertension Reports. 19 (4): 25. doi:10.1007/s11906-017-0722-5. PMC 5584783. PMID 28315048.
Kaye DM, Shihata WA, Jama HA, Tsyganov K, Ziemann M, Kiriazis H, et al. (April 2020). "Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease". Circulation. 141 (17): 1393–1403. doi:10.1161/CIRCULATIONAHA.119.043081. hdl:10536/DRO/DU:30135388. PMID 32093510. S2CID 211476145.
Iacobucci G (March 2023). "Appetite suppressant semaglutide is to be made available to treat obesity in England". BMJ. 380: 556. doi:10.1136/bmj.p556. PMID 36889753. S2CID 257379156.
Lee DH, Heo KS, Myung CS (July 2023). "Gα_i -coupled GPR41 activation increases Ca²⁺ influx in C2C12 cells and shows a therapeutic effect in diabetic animals". Obesity. 31 (7): 1871–1883. doi:10.1002/oby.23786. PMID 37309717. S2CID 259147907.
R Muralitharan R, Zheng T, Dinakis E, Xie L, Barbaro-Wahl A, Jama HA, et al. (February 2025). "Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension". Circulation Research. 136 (4): e20 – e33. doi:10.1161/CIRCRESAHA.124.325770. PMID 39840468.
R Muralitharan R, Marques FZ (February 2021). "Diet-related gut microbial metabolites and sensing in hypertension". Journal of Human Hypertension. 35 (2): 162–169. doi:10.1038/s41371-020-0388-3. PMID 32733062. S2CID 220881080.
Dinakis E, Nakai M, Gill PA, Yiallourou S, Sata Y, Muir J, et al. (November 2021). "The Gut Microbiota and Their Metabolites in Human Arterial Stiffness" (PDF). Heart, Lung & Circulation. 30 (11): 1716–1725. doi:10.1016/j.hlc.2021.07.022. PMID 34452845. S2CID 237340692.
Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. (February 2014). "Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis". Nature Medicine. 20 (2): 159–166. doi:10.1038/nm.3444. PMID 24390308. S2CID 35298402.
Ito T, Nakanishi Y, Shibata R, Sato N, Jinnohara T, Suzuki S, et al. (2023). "The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset". Gut Microbes. 15 (1): 2206507. doi:10.1080/19490976.2023.2206507. PMC 10158560. PMID 37131293.
Depner M, Taft DH, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S, et al. (November 2020). "Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma". Nature Medicine. 26 (11): 1766–1775. doi:10.1038/s41591-020-1095-x. hdl:2164/16359. PMID 33139948. S2CID 226244474.
Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, et al. (September 2015). "Early infancy microbial and metabolic alterations affect risk of childhood asthma". Science Translational Medicine. 7 (307): 307ra152. doi:10.1126/scitranslmed.aab2271. PMID 26424567. S2CID 206687974.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000185897 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019429 – Ensembl, May 2017

figshare.com

Gabriel FC, Fantuzzi G (December 2019). "The association of short-chain fatty acids and leptin metabolism: a systematic review". Nutrition Research. 72: 18–35. doi:10.1016/j.nutres.2019.08.006. PMID 31669116. S2CID 155928278.

handle.net

hdl.handle.net

Voltolini C, Battersby S, Etherington SL, Petraglia F, Norman JE, Jabbour HN (January 2012). "A novel antiinflammatory role for the short-chain fatty acids in human labor". Endocrinology. 153 (1): 395–403. doi:10.1210/en.2011-1457. hdl:20.500.11820/7035e8fd-062a-491a-9943-f20ad03844dd. PMID 22186417. S2CID 34431654.
Kaye DM, Shihata WA, Jama HA, Tsyganov K, Ziemann M, Kiriazis H, et al. (April 2020). "Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease". Circulation. 141 (17): 1393–1403. doi:10.1161/CIRCULATIONAHA.119.043081. hdl:10536/DRO/DU:30135388. PMID 32093510. S2CID 211476145.
Depner M, Taft DH, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S, et al. (November 2020). "Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma". Nature Medicine. 26 (11): 1766–1775. doi:10.1038/s41591-020-1095-x. hdl:2164/16359. PMID 33139948. S2CID 226244474.

harvard.edu

ui.adsabs.harvard.edu

Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, et al. (January 2018). "20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1". Nature Communications. 9 (1): 177. Bibcode:2018NatCo...9..177T. doi:10.1038/s41467-017-02539-4. PMC 5766607. PMID 29330456.
Ang Z, Er JZ, Tan NS, Lu J, Liou YC, Grosse J, et al. (September 2016). "Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists". Scientific Reports. 6: 34145. Bibcode:2016NatSR...634145A. doi:10.1038/srep34145. PMC 5036191. PMID 27667443.
Shimizu H, Masujima Y, Ushiroda C, Mizushima R, Taira S, Ohue-Kitano R, et al. (November 2019). "Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3". Scientific Reports. 9 (1): 16574. Bibcode:2019NatSR...916574S. doi:10.1038/s41598-019-53242-x. PMC 6851370. PMID 31719611.
Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, et al. (March 2013). "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America. 110 (11): 4410–4415. Bibcode:2013PNAS..110.4410P. doi:10.1073/pnas.1215927110. PMC 3600440. PMID 23401498.
Yuan G, Wen S, Zhong X, Yang X, Xie L, Wu X, et al. (2023). "Inulin alleviates offspring asthma by altering maternal intestinal microbiome composition to increase short-chain fatty acids". PLOS ONE. 18 (4): e0283105. Bibcode:2023PLoSO..1883105Y. doi:10.1371/journal.pone.0283105. PMC 10072493. PMID 37014871.
Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, et al. (May 2011). "Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 8030–8035. Bibcode:2011PNAS..108.8030K. doi:10.1073/pnas.1016088108. PMC 3093469. PMID 21518883.

nih.gov

pubmed.ncbi.nlm.nih.gov

Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF (October 1997). "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochemical and Biophysical Research Communications. 239 (2): 543–547. doi:10.1006/bbrc.1997.7513. PMID 9344866.
Karmokar PF, Moniri NH (December 2022). "Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells". Biochemical Pharmacology. 206: 115328. doi:10.1016/j.bcp.2022.115328. PMID 36309079. S2CID 253174629.
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, et al. (March 2003). "The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids". The Journal of Biological Chemistry. 278 (13): 11303–11311. doi:10.1074/jbc.M211495200. PMID 12496284.
Tunaru S, Bonnavion R, Brandenburger I, Preussner J, Thomas D, Scholich K, et al. (January 2018). "20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1". Nature Communications. 9 (1): 177. Bibcode:2018NatCo...9..177T. doi:10.1038/s41467-017-02539-4. PMC 5766607. PMID 29330456.
Grundmann M, Bender E, Schamberger J, Eitner F (February 2021). "Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators". International Journal of Molecular Sciences. 22 (4): 1763. doi:10.3390/ijms22041763. PMC 7916689. PMID 33578942.
Offermanns S (March 2017). "Hydroxy-Carboxylic Acid Receptor Actions in Metabolism". Trends in Endocrinology and Metabolism. 28 (3): 227–236. doi:10.1016/j.tem.2016.11.007. PMID 28087125. S2CID 39660018.
Mishra SP, Karunakar P, Taraphder S, Yadav H (June 2020). "Free Fatty Acid Receptors 2 and 3 as Microbial Metabolite Sensors to Shape Host Health: Pharmacophysiological View". Biomedicines. 8 (6): 154. doi:10.3390/biomedicines8060154. PMC 7344995. PMID 32521775.
Secor JD, Fligor SC, Tsikis ST, Yu LJ, Puder M (2021). "Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease". Frontiers in Physiology. 12: 656441. doi:10.3389/fphys.2021.656441. PMC 8058363. PMID 33897464.
Ang Z, Xiong D, Wu M, Ding JL (January 2018). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". FASEB Journal. 32 (1): 289–303. doi:10.1096/fj.201700252RR. PMC 5731126. PMID 28883043.
Martin-Gallausiaux C, Marinelli L, Blottière HM, Larraufie P, Lapaque N (February 2021). "SCFA: mechanisms and functional importance in the gut". The Proceedings of the Nutrition Society. 80 (1): 37–49. doi:10.1017/S0029665120006916. PMID 32238208. S2CID 214772999.
Ang Z, Er JZ, Tan NS, Lu J, Liou YC, Grosse J, et al. (September 2016). "Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists". Scientific Reports. 6: 34145. Bibcode:2016NatSR...634145A. doi:10.1038/srep34145. PMC 5036191. PMID 27667443.
Carretta MD, Quiroga J, López R, Hidalgo MA, Burgos RA (2021). "Participation of Short-Chain Fatty Acids and Their Receptors in Gut Inflammation and Colon Cancer". Frontiers in Physiology. 12: 662739. doi:10.3389/fphys.2021.662739. PMC 8060628. PMID 33897470.
Tan JK, Macia L, Mackay CR (February 2023). "Dietary fiber and SCFAs in the regulation of mucosal immunity". The Journal of Allergy and Clinical Immunology. 151 (2): 361–370. doi:10.1016/j.jaci.2022.11.007. PMID 36543697. S2CID 254918066.
Ikeda T, Nishida A, Yamano M, Kimura I (November 2022). "Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases". Pharmacology & Therapeutics. 239: 108273. doi:10.1016/j.pharmthera.2022.108273. PMID 36057320. S2CID 251992642.
Obradovic M, Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart AJ, et al. (2021). "Leptin and Obesity: Role and Clinical Implication". Frontiers in Endocrinology. 12: 585887. doi:10.3389/fendo.2021.585887. PMC 8167040. PMID 34084149.
Navalón-Monllor V, Soriano-Romaní L, Silva M, de Las Hazas ML, Hernando-Quintana N, Suárez Diéguez T, et al. (August 2023). "Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms". Food & Function. 14 (16): 7317–7334. doi:10.1039/d3fo01257c. PMID 37470232. S2CID 259996464.
Shimizu H, Masujima Y, Ushiroda C, Mizushima R, Taira S, Ohue-Kitano R, et al. (November 2019). "Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3". Scientific Reports. 9 (1): 16574. Bibcode:2019NatSR...916574S. doi:10.1038/s41598-019-53242-x. PMC 6851370. PMID 31719611.
Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, et al. (March 2013). "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America. 110 (11): 4410–4415. Bibcode:2013PNAS..110.4410P. doi:10.1073/pnas.1215927110. PMC 3600440. PMID 23401498.
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Loona DP, Das B, Kaur R, Kumar R, Yadav AK (2023). "Free Fatty Acid Receptors (FFARs): Emerging Therapeutic Targets for the Management of Diabetes Mellitus". Current Medicinal Chemistry. 30 (30): 3404–3440. doi:10.2174/0929867329666220927113614. PMID 36173072. S2CID 252598831.
Kuwahara A, Kuwahara Y, Inui T, Marunaka Y (March 2018). "Regulation of Ion Transport in the Intestine by Free Fatty Acid Receptor 2 and 3: Possible Involvement of the Diffuse Chemosensory System". International Journal of Molecular Sciences. 19 (3): 735. doi:10.3390/ijms19030735. PMC 5877596. PMID 29510573.
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Christiansen CB, Gabe MB, Svendsen B, Dragsted LO, Rosenkilde MM, Holst JJ (July 2018). "The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon". American Journal of Physiology. Gastrointestinal and Liver Physiology. 315 (1): G53 – G65. doi:10.1152/ajpgi.00346.2017. PMID 29494208. S2CID 3633401.
Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, et al. (2020). "AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition". Therapeutic Advances in Medical Oncology. 12: 1758835920913432. doi:10.1177/1758835920913432. PMC 7517987. PMID 33014144.
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Teyani R, Moniri NH (December 2023). "Gut feelings in the islets: The role of the gut microbiome and the FFA2 and FFA3 receptors for short chain fatty acids on β-cell function and metabolic regulation". British Journal of Pharmacology. 180 (24): 3113–3129. doi:10.1111/bph.16225. PMID 37620991. S2CID 261121846.
Al Mahri S, Malik SS, Al Ibrahim M, Haji E, Dairi G, Mohammad S (February 2022). "Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook". Cells. 11 (4): 750. doi:10.3390/cells11040750. PMC 8870169. PMID 35203397.
Voltolini C, Battersby S, Etherington SL, Petraglia F, Norman JE, Jabbour HN (January 2012). "A novel antiinflammatory role for the short-chain fatty acids in human labor". Endocrinology. 153 (1): 395–403. doi:10.1210/en.2011-1457. hdl:20.500.11820/7035e8fd-062a-491a-9943-f20ad03844dd. PMID 22186417. S2CID 34431654.
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Kaye DM, Shihata WA, Jama HA, Tsyganov K, Ziemann M, Kiriazis H, et al. (April 2020). "Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease". Circulation. 141 (17): 1393–1403. doi:10.1161/CIRCULATIONAHA.119.043081. hdl:10536/DRO/DU:30135388. PMID 32093510. S2CID 211476145.
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Lee DH, Heo KS, Myung CS (July 2023). "Gα_i -coupled GPR41 activation increases Ca²⁺ influx in C2C12 cells and shows a therapeutic effect in diabetic animals". Obesity. 31 (7): 1871–1883. doi:10.1002/oby.23786. PMID 37309717. S2CID 259147907.
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Dinakis E, Nakai M, Gill PA, Yiallourou S, Sata Y, Muir J, et al. (November 2021). "The Gut Microbiota and Their Metabolites in Human Arterial Stiffness" (PDF). Heart, Lung & Circulation. 30 (11): 1716–1725. doi:10.1016/j.hlc.2021.07.022. PMID 34452845. S2CID 237340692.
Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. (February 2014). "Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis". Nature Medicine. 20 (2): 159–166. doi:10.1038/nm.3444. PMID 24390308. S2CID 35298402.
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Depner M, Taft DH, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S, et al. (November 2020). "Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma". Nature Medicine. 26 (11): 1766–1775. doi:10.1038/s41591-020-1095-x. hdl:2164/16359. PMID 33139948. S2CID 226244474.
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ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, et al. (2020). "AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition". Therapeutic Advances in Medical Oncology. 12: 1758835920913432. doi:10.1177/1758835920913432. PMC 7517987. PMID 33014144.
Hoyles L, Snelling T, Umlai UK, Nicholson JK, Carding SR, Glen RC, et al. (March 2018). "Microbiome-host systems interactions: protective effects of propionate upon the blood-brain barrier". Microbiome. 6 (1): 55. doi:10.1186/s40168-018-0439-y. PMC 5863458. PMID 29562936.
Al Mahri S, Malik SS, Al Ibrahim M, Haji E, Dairi G, Mohammad S (February 2022). "Free Fatty Acid Receptors (FFARs) in Adipose: Physiological Role and Therapeutic Outlook". Cells. 11 (4): 750. doi:10.3390/cells11040750. PMC 8870169. PMID 35203397.
Zamarbide M, Martinez-Pinilla E, Gil-Bea F, Yanagisawa M, Franco R, Perez-Mediavilla A (March 2022). "Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP_swe Alzheimer's Disease Mouse Model". International Journal of Molecular Sciences. 23 (7): 3533. doi:10.3390/ijms23073533. PMC 8999053. PMID 35408893.
Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, et al. (May 2011). "Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 8030–8035. Bibcode:2011PNAS..108.8030K. doi:10.1073/pnas.1016088108. PMC 3093469. PMID 21518883.
Cox MA, Jackson J, Stanton M, Rojas-Triana A, Bober L, Laverty M, et al. (November 2009). "Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines". World Journal of Gastroenterology. 15 (44): 5549–5557. doi:10.3748/wjg.15.5549. PMC 2785057. PMID 19938193.
Al Mahri S, Al Ghamdi A, Akiel M, Al Aujan M, Mohammad S, Aziz MA (May 2020). "Free fatty acids receptors 2 and 3 control cell proliferation by regulating cellular glucose uptake". World Journal of Gastrointestinal Oncology. 12 (5): 514–525. doi:10.4251/wjgo.v12.i5.514. PMC 7235185. PMID 32461783.
de Vos WM, Tilg H, Van Hul M, Cani PD (May 2022). "Gut microbiome and health: mechanistic insights". Gut. 71 (5): 1020–1032. doi:10.1136/gutjnl-2021-326789. PMC 8995832. PMID 35105664.
Pluznick JL (April 2017). "Microbial Short-Chain Fatty Acids and Blood Pressure Regulation". Current Hypertension Reports. 19 (4): 25. doi:10.1007/s11906-017-0722-5. PMC 5584783. PMID 28315048.
Ito T, Nakanishi Y, Shibata R, Sato N, Jinnohara T, Suzuki S, et al. (2023). "The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset". Gut Microbes. 15 (1): 2206507. doi:10.1080/19490976.2023.2206507. PMC 10158560. PMID 37131293.

semanticscholar.org

api.semanticscholar.org

Karmokar PF, Moniri NH (December 2022). "Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells". Biochemical Pharmacology. 206: 115328. doi:10.1016/j.bcp.2022.115328. PMID 36309079. S2CID 253174629.
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Kimura I, Ichimura A, Ohue-Kitano R, Igarashi M (January 2020). "Free Fatty Acid Receptors in Health and Disease". Physiological Reviews. 100 (1): 171–210. doi:10.1152/physrev.00041.2018. PMID 31487233. S2CID 201845937.
Loona DP, Das B, Kaur R, Kumar R, Yadav AK (2023). "Free Fatty Acid Receptors (FFARs): Emerging Therapeutic Targets for the Management of Diabetes Mellitus". Current Medicinal Chemistry. 30 (30): 3404–3440. doi:10.2174/0929867329666220927113614. PMID 36173072. S2CID 252598831.
Christiansen CB, Gabe MB, Svendsen B, Dragsted LO, Rosenkilde MM, Holst JJ (July 2018). "The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon". American Journal of Physiology. Gastrointestinal and Liver Physiology. 315 (1): G53 – G65. doi:10.1152/ajpgi.00346.2017. PMID 29494208. S2CID 3633401.
Teyani R, Moniri NH (December 2023). "Gut feelings in the islets: The role of the gut microbiome and the FFA2 and FFA3 receptors for short chain fatty acids on β-cell function and metabolic regulation". British Journal of Pharmacology. 180 (24): 3113–3129. doi:10.1111/bph.16225. PMID 37620991. S2CID 261121846.
Voltolini C, Battersby S, Etherington SL, Petraglia F, Norman JE, Jabbour HN (January 2012). "A novel antiinflammatory role for the short-chain fatty acids in human labor". Endocrinology. 153 (1): 395–403. doi:10.1210/en.2011-1457. hdl:20.500.11820/7035e8fd-062a-491a-9943-f20ad03844dd. PMID 22186417. S2CID 34431654.
Miyasato S, Iwata K, Mura R, Nakamura S, Yanagida K, Shindou H, et al. (January 2023). "Constitutively active GPR43 is crucial for proper leukocyte differentiation". FASEB Journal. 37 (1): e22676. doi:10.1096/fj.202201591R. PMID 36468834. S2CID 254244683.
Gabriel FC, Fantuzzi G (December 2019). "The association of short-chain fatty acids and leptin metabolism: a systematic review". Nutrition Research. 72: 18–35. doi:10.1016/j.nutres.2019.08.006. PMID 31669116. S2CID 155928278.
Kaye DM, Shihata WA, Jama HA, Tsyganov K, Ziemann M, Kiriazis H, et al. (April 2020). "Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease". Circulation. 141 (17): 1393–1403. doi:10.1161/CIRCULATIONAHA.119.043081. hdl:10536/DRO/DU:30135388. PMID 32093510. S2CID 211476145.
Iacobucci G (March 2023). "Appetite suppressant semaglutide is to be made available to treat obesity in England". BMJ. 380: 556. doi:10.1136/bmj.p556. PMID 36889753. S2CID 257379156.
Lee DH, Heo KS, Myung CS (July 2023). "Gα_i -coupled GPR41 activation increases Ca²⁺ influx in C2C12 cells and shows a therapeutic effect in diabetic animals". Obesity. 31 (7): 1871–1883. doi:10.1002/oby.23786. PMID 37309717. S2CID 259147907.
R Muralitharan R, Marques FZ (February 2021). "Diet-related gut microbial metabolites and sensing in hypertension". Journal of Human Hypertension. 35 (2): 162–169. doi:10.1038/s41371-020-0388-3. PMID 32733062. S2CID 220881080.
Dinakis E, Nakai M, Gill PA, Yiallourou S, Sata Y, Muir J, et al. (November 2021). "The Gut Microbiota and Their Metabolites in Human Arterial Stiffness" (PDF). Heart, Lung & Circulation. 30 (11): 1716–1725. doi:10.1016/j.hlc.2021.07.022. PMID 34452845. S2CID 237340692.
Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, et al. (February 2014). "Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis". Nature Medicine. 20 (2): 159–166. doi:10.1038/nm.3444. PMID 24390308. S2CID 35298402.
Depner M, Taft DH, Kirjavainen PV, Kalanetra KM, Karvonen AM, Peschel S, et al. (November 2020). "Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma". Nature Medicine. 26 (11): 1766–1775. doi:10.1038/s41591-020-1095-x. hdl:2164/16359. PMID 33139948. S2CID 226244474.
Arrieta MC, Stiemsma LT, Dimitriu PA, Thorson L, Russell S, Yurist-Doutsch S, et al. (September 2015). "Early infancy microbial and metabolic alterations affect risk of childhood asthma". Science Translational Medicine. 7 (307): 307ra152. doi:10.1126/scitranslmed.aab2271. PMID 26424567. S2CID 206687974.

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