Analysis of information sources in references of the Wikipedia article "GABA" in English language version.
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Lastly, although it has been shown that GABA is an HDACi in a neuroblastoma cell line (Xing et al., 2019), in our hands, GABA does not inhibit HDACs to a detectable level in colonic epithelial cells (unpublished). While GABA is structurally similar to butyrate, surprisingly, it has not been discovered whether GABA can regulate butyrate-mediated pathways in IECs.
Lastly, although it has been shown that GABA is an HDACi in a neuroblastoma cell line (Xing et al., 2019), in our hands, GABA does not inhibit HDACs to a detectable level in colonic epithelial cells (unpublished). While GABA is structurally similar to butyrate, surprisingly, it has not been discovered whether GABA can regulate butyrate-mediated pathways in IECs.