GDF2 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "GDF2" in English language version.

Last modified: 09:04:09, 20 August 2026 (UTC)

Ref.Un. Ref.Website

Global rank English rank

4433nih.gov

5^th place

2620doi.org

2^nd place

65adsabs.harvard.edu

14^th place

9^th place

62ensembl.org

630^th place

326^th place

44semanticscholar.org

15^th place

8^th place

11uniprot.org

2,402^nd place

2,501^st place

adsabs.harvard.edu (Global: 14^th place; English: 9^th place)

ui.adsabs.harvard.edu

Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, et al. (March 2015). "Structure of bone morphogenetic protein 9 procomplex". Proceedings of the National Academy of Sciences of the United States of America. 112 (12): 3710–3715. Bibcode:2015PNAS..112.3710M. doi:10.1073/pnas.1501303112. PMC 4378411. PMID 25751889.
Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, et al. (May 2005). "Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons". Proceedings of the National Academy of Sciences of the United States of America. 102 (19): 6984–6989. Bibcode:2005PNAS..102.6984L. doi:10.1073/pnas.0502097102. PMC 1088172. PMID 15870197.
Truksa J, Peng H, Lee P, Beutler E (Jul 2006). "Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6". Proceedings of the National Academy of Sciences of the United States of America. 103 (27): 10289–10293. Bibcode:2006PNAS..10310289T. doi:10.1073/pnas.0603124103. PMC 1502450. PMID 16801541.
Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, et al. (May 2010). "A draft sequence of the Neandertal genome". Science. 328 (5979): 710–722. Bibcode:2010Sci...328..710G. doi:10.1126/science.1188021. PMC 5100745. PMID 20448178.
Herrera B, García-Álvaro M, Cruz S, Walsh P, Fernández M, Roncero C, et al. (July 2013). "BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells". PLOS ONE. 8 (7) e69535. Bibcode:2013PLoSO...869535H. doi:10.1371/journal.pone.0069535. PMC 3720667. PMID 23936038.

doi.org (Global: 2^nd place; English: 2^nd place)

Miller AF, Harvey SA, Thies RS, Olson MS (Jun 2000). "Bone morphogenetic protein-9. An autocrine/paracrine cytokine in the liver". The Journal of Biological Chemistry. 275 (24): 17937–17945. doi:10.1074/jbc.275.24.17937. PMID 10849432.
Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, et al. (March 2015). "Structure of bone morphogenetic protein 9 procomplex". Proceedings of the National Academy of Sciences of the United States of America. 112 (12): 3710–3715. Bibcode:2015PNAS..112.3710M. doi:10.1073/pnas.1501303112. PMC 4378411. PMID 25751889.
Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, et al. (May 2005). "Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons". Proceedings of the National Academy of Sciences of the United States of America. 102 (19): 6984–6989. Bibcode:2005PNAS..102.6984L. doi:10.1073/pnas.0502097102. PMC 1088172. PMID 15870197.
Truksa J, Peng H, Lee P, Beutler E (Jul 2006). "Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6". Proceedings of the National Academy of Sciences of the United States of America. 103 (27): 10289–10293. Bibcode:2006PNAS..10310289T. doi:10.1073/pnas.0603124103. PMC 1502450. PMID 16801541.
David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S (Mar 2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood. 109 (5): 1953–1961. doi:10.1182/blood-2006-07-034124. PMID 17068149.
McDonald J, Bayrak-Toydemir P, Pyeritz RE (Jul 2011). "Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis". Genetics in Medicine. 13 (7): 607–616. doi:10.1097/GIM.0b013e3182136d32. PMID 21546842.
Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, et al. (Sep 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy. 11 (17): 1312–1320. doi:10.1038/sj.gt.3302298. PMID 15269709. S2CID 24526533.
Sharff KA, Song WX, Luo X, Tang N, Luo J, Chen J, et al. (Jan 2009). "Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells". The Journal of Biological Chemistry. 284 (1): 649–659. doi:10.1074/jbc.M806389200. PMC 2610517. PMID 18986983.
Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, et al. (May 2010). "A draft sequence of the Neandertal genome". Science. 328 (5979): 710–722. Bibcode:2010Sci...328..710G. doi:10.1126/science.1188021. PMC 5100745. PMID 20448178.
Townson SA, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J, et al. (Aug 2012). "Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex". The Journal of Biological Chemistry. 287 (33): 27313–27325. doi:10.1074/jbc.M112.377960. PMC 3431715. PMID 22718755.
Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, et al. (Jul 2005). "Crystal structure of BMP-9 and functional interactions with pro-region and receptors". The Journal of Biological Chemistry. 280 (26): 25111–25118. doi:10.1074/jbc.M503328200. PMID 15851468.
Grynblat J, Bogaard HJ, Eyries M, Meyrignac O, Savale L, Jaïs X, et al. (April 2024). "Pulmonary vascular phenotype identified in patients with GDF2 (BMP9) or BMP10 variants: an international multicentre study". The European Respiratory Journal. 63 (4) 2301634. doi:10.1183/13993003.01634-2023. PMID 38514094.
Wooderchak-Donahue WL, McDonald J, O'Fallon B, Upton PD, Li W, Roman BL, et al. (Sep 2013). "BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia". American Journal of Human Genetics. 93 (3): 530–537. doi:10.1016/j.ajhg.2013.07.004. PMC 3769931. PMID 23972370.
Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, et al. (Mar 2013). "Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells". Cancer Science. 104 (3): 398–408. doi:10.1111/cas.12093. PMC 7657113. PMID 23281849. S2CID 9890953.
Herrera B, García-Álvaro M, Cruz S, Walsh P, Fernández M, Roncero C, et al. (July 2013). "BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells". PLOS ONE. 8 (7) e69535. Bibcode:2013PLoSO...869535H. doi:10.1371/journal.pone.0069535. PMC 3720667. PMID 23936038.
Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, et al. (Mar 2007). "BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis". Journal of Cell Science. 120 (Pt 6): 964–972. doi:10.1242/jcs.002949. PMID 17311849. S2CID 37306105.
Zhao YF, Xu J, Wang WJ, Wang J, He JW, Li L, et al. (Aug 2013). "Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells". BMB Reports. 46 (8): 422–427. doi:10.5483/BMBRep.2013.46.8.266. PMC 4133909. PMID 23977991.
Park H, Drevelle O, Daviau A, Senta H, Bergeron E, Faucheux N (Mar 2013). "Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9". Anti-Cancer Drugs. 24 (3): 278–290. doi:10.1097/CAD.0b013e32835cbde7. PMID 23262982. S2CID 29663731.
Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, et al. (Apr 2013). "Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro". Cellular Signalling. 25 (4): 717–728. doi:10.1016/j.cellsig.2012.12.003. PMID 23313128.
Li C, Yang X, He Y, Ye G, Li X, Zhang X, et al. (2012). "Bone morphogenetic protein-9 induces osteogenic differentiation of rat dental follicle stem cells in P38 and ERK1/2 MAPK dependent manner". International Journal of Medical Sciences. 9 (10): 862–871. doi:10.7150/ijms.5027. PMC 3498751. PMID 23155360.

ensembl.org (Global: 630^th place; English: 326^th place)

may2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000263761 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000072625 – Ensembl, May 2017

nih.gov (Global: 5^th place; English: 5^th place)

pubmed.ncbi.nlm.nih.gov

Miller AF, Harvey SA, Thies RS, Olson MS (Jun 2000). "Bone morphogenetic protein-9. An autocrine/paracrine cytokine in the liver". The Journal of Biological Chemistry. 275 (24): 17937–17945. doi:10.1074/jbc.275.24.17937. PMID 10849432.
Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, et al. (March 2015). "Structure of bone morphogenetic protein 9 procomplex". Proceedings of the National Academy of Sciences of the United States of America. 112 (12): 3710–3715. Bibcode:2015PNAS..112.3710M. doi:10.1073/pnas.1501303112. PMC 4378411. PMID 25751889.
Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, et al. (May 2005). "Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons". Proceedings of the National Academy of Sciences of the United States of America. 102 (19): 6984–6989. Bibcode:2005PNAS..102.6984L. doi:10.1073/pnas.0502097102. PMC 1088172. PMID 15870197.
Truksa J, Peng H, Lee P, Beutler E (Jul 2006). "Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6". Proceedings of the National Academy of Sciences of the United States of America. 103 (27): 10289–10293. Bibcode:2006PNAS..10310289T. doi:10.1073/pnas.0603124103. PMC 1502450. PMID 16801541.
David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S (Mar 2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood. 109 (5): 1953–1961. doi:10.1182/blood-2006-07-034124. PMID 17068149.
McDonald J, Bayrak-Toydemir P, Pyeritz RE (Jul 2011). "Hereditary hemorrhagic telangiectasia: an overview of diagnosis, management, and pathogenesis". Genetics in Medicine. 13 (7): 607–616. doi:10.1097/GIM.0b013e3182136d32. PMID 21546842.
Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, et al. (Sep 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy. 11 (17): 1312–1320. doi:10.1038/sj.gt.3302298. PMID 15269709. S2CID 24526533.
Sharff KA, Song WX, Luo X, Tang N, Luo J, Chen J, et al. (Jan 2009). "Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells". The Journal of Biological Chemistry. 284 (1): 649–659. doi:10.1074/jbc.M806389200. PMC 2610517. PMID 18986983.
Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, et al. (May 2010). "A draft sequence of the Neandertal genome". Science. 328 (5979): 710–722. Bibcode:2010Sci...328..710G. doi:10.1126/science.1188021. PMC 5100745. PMID 20448178.
Townson SA, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J, et al. (Aug 2012). "Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex". The Journal of Biological Chemistry. 287 (33): 27313–27325. doi:10.1074/jbc.M112.377960. PMC 3431715. PMID 22718755.
Brown MA, Zhao Q, Baker KA, Naik C, Chen C, Pukac L, et al. (Jul 2005). "Crystal structure of BMP-9 and functional interactions with pro-region and receptors". The Journal of Biological Chemistry. 280 (26): 25111–25118. doi:10.1074/jbc.M503328200. PMID 15851468.
Grynblat J, Bogaard HJ, Eyries M, Meyrignac O, Savale L, Jaïs X, et al. (April 2024). "Pulmonary vascular phenotype identified in patients with GDF2 (BMP9) or BMP10 variants: an international multicentre study". The European Respiratory Journal. 63 (4) 2301634. doi:10.1183/13993003.01634-2023. PMID 38514094.
Wooderchak-Donahue WL, McDonald J, O'Fallon B, Upton PD, Li W, Roman BL, et al. (Sep 2013). "BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia". American Journal of Human Genetics. 93 (3): 530–537. doi:10.1016/j.ajhg.2013.07.004. PMC 3769931. PMID 23972370.
Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, et al. (Mar 2013). "Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells". Cancer Science. 104 (3): 398–408. doi:10.1111/cas.12093. PMC 7657113. PMID 23281849. S2CID 9890953.
Herrera B, García-Álvaro M, Cruz S, Walsh P, Fernández M, Roncero C, et al. (July 2013). "BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells". PLOS ONE. 8 (7) e69535. Bibcode:2013PLoSO...869535H. doi:10.1371/journal.pone.0069535. PMC 3720667. PMID 23936038.
Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, et al. (Mar 2007). "BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis". Journal of Cell Science. 120 (Pt 6): 964–972. doi:10.1242/jcs.002949. PMID 17311849. S2CID 37306105.
Zhao YF, Xu J, Wang WJ, Wang J, He JW, Li L, et al. (Aug 2013). "Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells". BMB Reports. 46 (8): 422–427. doi:10.5483/BMBRep.2013.46.8.266. PMC 4133909. PMID 23977991.
Park H, Drevelle O, Daviau A, Senta H, Bergeron E, Faucheux N (Mar 2013). "Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9". Anti-Cancer Drugs. 24 (3): 278–290. doi:10.1097/CAD.0b013e32835cbde7. PMID 23262982. S2CID 29663731.
Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, et al. (Apr 2013). "Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro". Cellular Signalling. 25 (4): 717–728. doi:10.1016/j.cellsig.2012.12.003. PMID 23313128.
Li C, Yang X, He Y, Ye G, Li X, Zhang X, et al. (2012). "Bone morphogenetic protein-9 induces osteogenic differentiation of rat dental follicle stem cells in P38 and ERK1/2 MAPK dependent manner". International Journal of Medical Sciences. 9 (10): 862–871. doi:10.7150/ijms.5027. PMC 3498751. PMID 23155360.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, et al. (March 2015). "Structure of bone morphogenetic protein 9 procomplex". Proceedings of the National Academy of Sciences of the United States of America. 112 (12): 3710–3715. Bibcode:2015PNAS..112.3710M. doi:10.1073/pnas.1501303112. PMC 4378411. PMID 25751889.
Lopez-Coviella I, Follettie MT, Mellott TJ, Kovacheva VP, Slack BE, Diesl V, et al. (May 2005). "Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons". Proceedings of the National Academy of Sciences of the United States of America. 102 (19): 6984–6989. Bibcode:2005PNAS..102.6984L. doi:10.1073/pnas.0502097102. PMC 1088172. PMID 15870197.
Truksa J, Peng H, Lee P, Beutler E (Jul 2006). "Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6". Proceedings of the National Academy of Sciences of the United States of America. 103 (27): 10289–10293. Bibcode:2006PNAS..10310289T. doi:10.1073/pnas.0603124103. PMC 1502450. PMID 16801541.
Sharff KA, Song WX, Luo X, Tang N, Luo J, Chen J, et al. (Jan 2009). "Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells". The Journal of Biological Chemistry. 284 (1): 649–659. doi:10.1074/jbc.M806389200. PMC 2610517. PMID 18986983.
Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, et al. (May 2010). "A draft sequence of the Neandertal genome". Science. 328 (5979): 710–722. Bibcode:2010Sci...328..710G. doi:10.1126/science.1188021. PMC 5100745. PMID 20448178.
Townson SA, Martinez-Hackert E, Greppi C, Lowden P, Sako D, Liu J, et al. (Aug 2012). "Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex". The Journal of Biological Chemistry. 287 (33): 27313–27325. doi:10.1074/jbc.M112.377960. PMC 3431715. PMID 22718755.
Wooderchak-Donahue WL, McDonald J, O'Fallon B, Upton PD, Li W, Roman BL, et al. (Sep 2013). "BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia". American Journal of Human Genetics. 93 (3): 530–537. doi:10.1016/j.ajhg.2013.07.004. PMC 3769931. PMID 23972370.
Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, et al. (Mar 2013). "Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells". Cancer Science. 104 (3): 398–408. doi:10.1111/cas.12093. PMC 7657113. PMID 23281849. S2CID 9890953.
Herrera B, García-Álvaro M, Cruz S, Walsh P, Fernández M, Roncero C, et al. (July 2013). "BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells". PLOS ONE. 8 (7) e69535. Bibcode:2013PLoSO...869535H. doi:10.1371/journal.pone.0069535. PMC 3720667. PMID 23936038.
Zhao YF, Xu J, Wang WJ, Wang J, He JW, Li L, et al. (Aug 2013). "Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells". BMB Reports. 46 (8): 422–427. doi:10.5483/BMBRep.2013.46.8.266. PMC 4133909. PMID 23977991.
Li C, Yang X, He Y, Ye G, Li X, Zhang X, et al. (2012). "Bone morphogenetic protein-9 induces osteogenic differentiation of rat dental follicle stem cells in P38 and ERK1/2 MAPK dependent manner". International Journal of Medical Sciences. 9 (10): 862–871. doi:10.7150/ijms.5027. PMC 3498751. PMID 23155360.

semanticscholar.org (Global: 15^th place; English: 8^th place)

api.semanticscholar.org

Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, et al. (Sep 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy. 11 (17): 1312–1320. doi:10.1038/sj.gt.3302298. PMID 15269709. S2CID 24526533.
Li Q, Gu X, Weng H, Ghafoory S, Liu Y, Feng T, et al. (Mar 2013). "Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells". Cancer Science. 104 (3): 398–408. doi:10.1111/cas.12093. PMC 7657113. PMID 23281849. S2CID 9890953.
Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, et al. (Mar 2007). "BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis". Journal of Cell Science. 120 (Pt 6): 964–972. doi:10.1242/jcs.002949. PMID 17311849. S2CID 37306105.
Park H, Drevelle O, Daviau A, Senta H, Bergeron E, Faucheux N (Mar 2013). "Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9". Anti-Cancer Drugs. 24 (3): 278–290. doi:10.1097/CAD.0b013e32835cbde7. PMID 23262982. S2CID 29663731.

uniprot.org (Global: 2,402^nd place; English: 2,501^st place)

Universal protein resource accession number Q9UK05 at UniProt.

GDF2 (English Wikipedia)

adsabs.harvard.edu (Global: 14th place; English: 9th place)

ui.adsabs.harvard.edu

doi.org (Global: 2nd place; English: 2nd place)

ensembl.org (Global: 630th place; English: 326th place)