Glutamate hypothesis of schizophrenia (English Wikipedia)

Vita, A; De Peri, L; Deste, G; Barlati, S; Sacchetti, E (2015). "The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies". Biological Psychiatry. 78 (6): 403–12. doi:10.1016/j.biopsych.2015.02.008. hdl:11379/458510. PMID 25802081. S2CID 27008041.

harvard.edu

ui.adsabs.harvard.edu

Behrens MM, Ali SS, Dao DN, et al. (December 2007). "Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase". Science. 318 (5856): 1645–7. Bibcode:2007Sci...318.1645B. doi:10.1126/science.1148045. PMID 18063801. S2CID 41932041.
Guo, W.; Shi, L.; Filizola, M.; Weinstein, H.; Javitch, J. A. (2005). "Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation". Proceedings of the National Academy of Sciences. 102 (48): 17495–500. Bibcode:2005PNAS..10217495G. doi:10.1073/pnas.0508950102. PMC 1287488. PMID 16301531.
Barros, C. S.; Calabrese, B.; Chamero, P.; Roberts, A. J.; Korzus, E.; Lloyd, K.; Stowers, L.; Mayford, M.; Halpain, S.; Muller, U. (2009). "Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system". Proceedings of the National Academy of Sciences. 106 (11): 4507–12. Bibcode:2009PNAS..106.4507B. doi:10.1073/pnas.0900355106. PMC 2657442. PMID 19240213.

lilly.com

newsroom.lilly.com

Eli Lilly and Company - Lilly Announces Inconclusive Phase II Study Results for mGlu2/3 at the International Congress on Schizophrenia Research, Eli Lilly, 29 March 2009

nih.gov

pubmed.ncbi.nlm.nih.gov

Lisman JE, Coyle JT, Green RW, et al. (May 2008). "Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia". Trends in Neurosciences. 31 (5): 234–42. doi:10.1016/j.tins.2008.02.005. PMC 2680493. PMID 18395805.
Behrens MM, Ali SS, Dao DN, et al. (December 2007). "Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase". Science. 318 (5856): 1645–7. Bibcode:2007Sci...318.1645B. doi:10.1126/science.1148045. PMID 18063801. S2CID 41932041.
Nakao S, Nagata A, Masuzawa M, et al. (June 2003). "NMDA receptor antagonist neurotoxicity and psychotomimetic activity". The Japanese Journal of Anesthesiology. 52 (6): 594–602. PMID 12854473.
Moreno, José L.; Holloway, Terrell; Albizu, Laura; Sealfon, Stuart C.; González-Maeso, Javier (2011). "Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists". Neuroscience Letters. 493 (3): 76–9. doi:10.1016/j.neulet.2011.01.046. PMC 3064746. PMID 21276828.
Guo, W.; Shi, L.; Filizola, M.; Weinstein, H.; Javitch, J. A. (2005). "Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation". Proceedings of the National Academy of Sciences. 102 (48): 17495–500. Bibcode:2005PNAS..10217495G. doi:10.1073/pnas.0508950102. PMC 1287488. PMID 16301531.
Tucholski, J; Simmons, M. S.; Pinner, A. L.; Haroutunian, V; McCullumsmith, R. E.; Meador-Woodruff, J. H. (2013). "Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia". Schizophrenia Research. 146 (1–3): 177–83. doi:10.1016/j.schres.2013.01.031. PMC 3655690. PMID 23462048.
Fatemi, S. H.; Earle, J. A.; McMenomy, T (2000). "Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression". Molecular Psychiatry. 5 (6): 654–63, 571. doi:10.1038/sj.mp.4000783. PMID 11126396.
Green, M. J.; Matheson, S. L.; Shepherd, A; Weickert, C. S.; Carr, V. J. (2011). "Brain-derived neurotrophic factor levels in schizophrenia: A systematic review with meta-analysis". Molecular Psychiatry. 16 (9): 960–72. doi:10.1038/mp.2010.88. PMID 20733577.
Yoshimura, Reiji; Hori, Hikaru; Katsuki, Asuka; Atake, Kiyokazu; Nakamura, Jun (2016). "Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia". Annals of General Psychiatry. 15: 1. doi:10.1186/s12991-015-0084-9. PMC 4712493. PMID 26770258.
Jourdi, H; Hsu, Y. T.; Zhou, M; Qin, Q; Bi, X; Baudry, M (2009). "Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation". Journal of Neuroscience. 29 (27): 8688–97. doi:10.1523/JNEUROSCI.6078-08.2009. PMC 2761758. PMID 19587275.
Kellner, Y; Gödecke, N; Dierkes, T; Thieme, N; Zagrebelsky, M; Korte, M (2014). "The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity". Frontiers in Synaptic Neuroscience. 6: 5. doi:10.3389/fnsyn.2014.00005. PMC 3960490. PMID 24688467.
Zakharyan, Roksana; Atshemyan, Sofi; Gevorgyan, Anaida; Boyajyan, Anna (2014). "Nerve growth factor and its receptor in schizophrenia". BBA Clinical. 1: 24–9. doi:10.1016/j.bbacli.2014.05.001. PMC 4633968. PMID 26675984.
Roussos, P; Katsel, P; Davis, K. L.; Giakoumaki, S. G.; Lencz, T; Malhotra, A. K.; Siever, L. J.; Bitsios, P; Haroutunian, V (2013). "Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia". Neuropsychopharmacology. 38 (3): 533–9. doi:10.1038/npp.2012.215. PMC 3547205. PMID 23132271.
Ortega-Alvaro, Antonio; Aracil-Fernández, Auxiliadora; García-Gutiérrez, María S; Navarrete, Francisco; Manzanares, Jorge (2011). "Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice". Neuropsychopharmacology. 36 (7): 1489–504. doi:10.1038/npp.2011.34. PMC 3096817. PMID 21430651.
Uzbay, T; Goktalay, G; Kayir, H; Eker, S. S.; Sarandol, A; Oral, S; Buyukuysal, L; Ulusoy, G; Kirli, S (2013). "Increased plasma agmatine levels in patients with schizophrenia". Journal of Psychiatric Research. 47 (8): 1054–60. doi:10.1016/j.jpsychires.2013.04.004. PMID 23664672.
Erhardt, S; Schwieler, L; Nilsson, L; Linderholm, K; Engberg, G (2007). "The kynurenic acid hypothesis of schizophrenia". Physiology & Behavior. 92 (1–2): 203–9. doi:10.1016/j.physbeh.2007.05.025. PMID 17573079. S2CID 46156877.
Vita, A; De Peri, L; Deste, G; Barlati, S; Sacchetti, E (2015). "The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies". Biological Psychiatry. 78 (6): 403–12. doi:10.1016/j.biopsych.2015.02.008. hdl:11379/458510. PMID 25802081. S2CID 27008041.
Bantick, R. A.; Deakin, J. F.; Grasby, P. M. (2001). "The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?". Journal of Psychopharmacology. 15 (1): 37–46. doi:10.1177/026988110101500108. ISSN 0269-8811. PMID 11277607. S2CID 24853534.
Labrie, Viviane; Fukumura, Ryutaro; Rastogi, Anjali; Fick, Laura J.; Wang, Wei; Boutros, Paul C.; Kennedy, James L.; Semeralul, Mawahib O.; Lee, Frankie H. (2009-09-01). "Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model". Human Molecular Genetics. 18 (17): 3227–3243. doi:10.1093/hmg/ddp261. ISSN 1460-2083. PMC 2722985. PMID 19483194.
Wearne, Travis A.; Cornish, Jennifer L. (2018-10-10). "A Comparison of Methamphetamine-Induced Psychosis and Schizophrenia: A Review of Positive, Negative, and Cognitive Symptomatology". Frontiers in Psychiatry. 9: 491. doi:10.3389/fpsyt.2018.00491. ISSN 1664-0640. PMC 6191498. PMID 30364176.
Reynolds LM, Cochran SM, Morris BJ, Pratt JA, Reynolds GP (March 2005). "Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain". Schizophrenia Research. 73 (2–3): 147–52. doi:10.1016/j.schres.2004.02.003. PMID 15653257. S2CID 1651693.
Patil ST, Zhang L, Martenyi F, et al. (September 2007). "Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial". Nature Medicine. 13 (9): 1102–7. doi:10.1038/nm1632. PMID 17767166. S2CID 6417333.
Harrison PJ, Weinberger DR (January 2005). "Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence". Molecular Psychiatry. 10 (1): 40–68, image 5. doi:10.1038/sj.mp.4001558. PMID 15263907.
Tiihonen, J; Wahlbeck, K (2006). "Glutamatergic drugs for schizophrenia". Cochrane Database of Systematic Reviews. 2 (2): CD003730.pub2. doi:10.1002/14651858.CD003730.pub2. PMID 16625590.
Barros, C. S.; Calabrese, B.; Chamero, P.; Roberts, A. J.; Korzus, E.; Lloyd, K.; Stowers, L.; Mayford, M.; Halpain, S.; Muller, U. (2009). "Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system". Proceedings of the National Academy of Sciences. 106 (11): 4507–12. Bibcode:2009PNAS..106.4507B. doi:10.1073/pnas.0900355106. PMC 2657442. PMID 19240213.

ncbi.nlm.nih.gov

Lisman JE, Coyle JT, Green RW, et al. (May 2008). "Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia". Trends in Neurosciences. 31 (5): 234–42. doi:10.1016/j.tins.2008.02.005. PMC 2680493. PMID 18395805.
Moreno, José L.; Holloway, Terrell; Albizu, Laura; Sealfon, Stuart C.; González-Maeso, Javier (2011). "Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists". Neuroscience Letters. 493 (3): 76–9. doi:10.1016/j.neulet.2011.01.046. PMC 3064746. PMID 21276828.
Guo, W.; Shi, L.; Filizola, M.; Weinstein, H.; Javitch, J. A. (2005). "Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation". Proceedings of the National Academy of Sciences. 102 (48): 17495–500. Bibcode:2005PNAS..10217495G. doi:10.1073/pnas.0508950102. PMC 1287488. PMID 16301531.
Tucholski, J; Simmons, M. S.; Pinner, A. L.; Haroutunian, V; McCullumsmith, R. E.; Meador-Woodruff, J. H. (2013). "Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia". Schizophrenia Research. 146 (1–3): 177–83. doi:10.1016/j.schres.2013.01.031. PMC 3655690. PMID 23462048.
Yoshimura, Reiji; Hori, Hikaru; Katsuki, Asuka; Atake, Kiyokazu; Nakamura, Jun (2016). "Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia". Annals of General Psychiatry. 15: 1. doi:10.1186/s12991-015-0084-9. PMC 4712493. PMID 26770258.
Jourdi, H; Hsu, Y. T.; Zhou, M; Qin, Q; Bi, X; Baudry, M (2009). "Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation". Journal of Neuroscience. 29 (27): 8688–97. doi:10.1523/JNEUROSCI.6078-08.2009. PMC 2761758. PMID 19587275.
Kellner, Y; Gödecke, N; Dierkes, T; Thieme, N; Zagrebelsky, M; Korte, M (2014). "The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity". Frontiers in Synaptic Neuroscience. 6: 5. doi:10.3389/fnsyn.2014.00005. PMC 3960490. PMID 24688467.
Zakharyan, Roksana; Atshemyan, Sofi; Gevorgyan, Anaida; Boyajyan, Anna (2014). "Nerve growth factor and its receptor in schizophrenia". BBA Clinical. 1: 24–9. doi:10.1016/j.bbacli.2014.05.001. PMC 4633968. PMID 26675984.
Roussos, P; Katsel, P; Davis, K. L.; Giakoumaki, S. G.; Lencz, T; Malhotra, A. K.; Siever, L. J.; Bitsios, P; Haroutunian, V (2013). "Convergent findings for abnormalities of the NF-κB signaling pathway in schizophrenia". Neuropsychopharmacology. 38 (3): 533–9. doi:10.1038/npp.2012.215. PMC 3547205. PMID 23132271.
Ortega-Alvaro, Antonio; Aracil-Fernández, Auxiliadora; García-Gutiérrez, María S; Navarrete, Francisco; Manzanares, Jorge (2011). "Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice". Neuropsychopharmacology. 36 (7): 1489–504. doi:10.1038/npp.2011.34. PMC 3096817. PMID 21430651.
Labrie, Viviane; Fukumura, Ryutaro; Rastogi, Anjali; Fick, Laura J.; Wang, Wei; Boutros, Paul C.; Kennedy, James L.; Semeralul, Mawahib O.; Lee, Frankie H. (2009-09-01). "Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model". Human Molecular Genetics. 18 (17): 3227–3243. doi:10.1093/hmg/ddp261. ISSN 1460-2083. PMC 2722985. PMID 19483194.
Wearne, Travis A.; Cornish, Jennifer L. (2018-10-10). "A Comparison of Methamphetamine-Induced Psychosis and Schizophrenia: A Review of Positive, Negative, and Cognitive Symptomatology". Frontiers in Psychiatry. 9: 491. doi:10.3389/fpsyt.2018.00491. ISSN 1664-0640. PMC 6191498. PMID 30364176.
Barros, C. S.; Calabrese, B.; Chamero, P.; Roberts, A. J.; Korzus, E.; Lloyd, K.; Stowers, L.; Mayford, M.; Halpain, S.; Muller, U. (2009). "Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system". Proceedings of the National Academy of Sciences. 106 (11): 4507–12. Bibcode:2009PNAS..106.4507B. doi:10.1073/pnas.0900355106. PMC 2657442. PMID 19240213.

nytimes.com

Berenson, Alex (2008-02-24). "Daring to Think Differently About Schizophrenia". The New York Times. Retrieved 2010-05-03.

semanticscholar.org

api.semanticscholar.org

Behrens MM, Ali SS, Dao DN, et al. (December 2007). "Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase". Science. 318 (5856): 1645–7. Bibcode:2007Sci...318.1645B. doi:10.1126/science.1148045. PMID 18063801. S2CID 41932041.
Erhardt, S; Schwieler, L; Nilsson, L; Linderholm, K; Engberg, G (2007). "The kynurenic acid hypothesis of schizophrenia". Physiology & Behavior. 92 (1–2): 203–9. doi:10.1016/j.physbeh.2007.05.025. PMID 17573079. S2CID 46156877.
Vita, A; De Peri, L; Deste, G; Barlati, S; Sacchetti, E (2015). "The Effect of Antipsychotic Treatment on Cortical Gray Matter Changes in Schizophrenia: Does the Class Matter? A Meta-analysis and Meta-regression of Longitudinal Magnetic Resonance Imaging Studies". Biological Psychiatry. 78 (6): 403–12. doi:10.1016/j.biopsych.2015.02.008. hdl:11379/458510. PMID 25802081. S2CID 27008041.
Bantick, R. A.; Deakin, J. F.; Grasby, P. M. (2001). "The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?". Journal of Psychopharmacology. 15 (1): 37–46. doi:10.1177/026988110101500108. ISSN 0269-8811. PMID 11277607. S2CID 24853534.
Reynolds LM, Cochran SM, Morris BJ, Pratt JA, Reynolds GP (March 2005). "Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain". Schizophrenia Research. 73 (2–3): 147–52. doi:10.1016/j.schres.2004.02.003. PMID 15653257. S2CID 1651693.
Patil ST, Zhang L, Martenyi F, et al. (September 2007). "Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial". Nature Medicine. 13 (9): 1102–7. doi:10.1038/nm1632. PMID 17767166. S2CID 6417333.

worldcat.org

search.worldcat.org

Bantick, R. A.; Deakin, J. F.; Grasby, P. M. (2001). "The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?". Journal of Psychopharmacology. 15 (1): 37–46. doi:10.1177/026988110101500108. ISSN 0269-8811. PMID 11277607. S2CID 24853534.
Labrie, Viviane; Fukumura, Ryutaro; Rastogi, Anjali; Fick, Laura J.; Wang, Wei; Boutros, Paul C.; Kennedy, James L.; Semeralul, Mawahib O.; Lee, Frankie H. (2009-09-01). "Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model". Human Molecular Genetics. 18 (17): 3227–3243. doi:10.1093/hmg/ddp261. ISSN 1460-2083. PMC 2722985. PMID 19483194.
Wearne, Travis A.; Cornish, Jennifer L. (2018-10-10). "A Comparison of Methamphetamine-Induced Psychosis and Schizophrenia: A Review of Positive, Negative, and Cognitive Symptomatology". Frontiers in Psychiatry. 9: 491. doi:10.3389/fpsyt.2018.00491. ISSN 1664-0640. PMC 6191498. PMID 30364176.