Helenalin (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Helenalin" in English language version.

refsWebsite

Global rank English rank

22nih.gov

4^th place

20doi.org

2^nd place

4semanticscholar.org

11^th place

8^th place

1harvard.edu

18^th place

17^th place

1clinicaltrials.gov

5,225^th place

4,062^nd place

clinicaltrials.gov

"U.S. National Library of Medicine," [Online]. Available: https://clinicaltrials.gov/ct2/results?cond=&term=arnica+montana&cntry=&state=&city=&dist=. [Accessed 8 March 2018].

doi.org

Perry NB, Burgess EJ, Rodríguez Guitián MA, Romero Franco R, López Mosquera E, Smallfield BM, Joyce NI, Littlejohn RP (May 2009). "Sesquiterpene lactones in Arnica montana: helenalin and dihydrohelenalin chemotypes in Spain". Planta Medica. 75 (6): 660–6. doi:10.1055/s-0029-1185362. PMID 19235681.
Tornhamre, Susanne; Schmidt, Thomas J.; Näsman-Glaser, Barbro; Ericsson, Inger; Lindgren, Jan Åke (2001). "Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C 4 synthase in human blood cells". Biochemical Pharmacology. 62 (7): 903–911. doi:10.1016/S0006-2952(01)00729-8. PMID 11543725.
Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA (February 2018). "Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles". ChemMedChem. 13 (4): 303–311. doi:10.1002/cmdc.201700752. PMC 5894512. PMID 29349898.
Zwicker P, Schultze N, Niehs S, Albrecht D, Methling K, Wurster M, Wachlin G, Lalk M, Lindequist U, Haertel B (April 2017). "Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types". Toxicology in Vitro. 40: 45–54. doi:10.1016/j.tiv.2016.12.010. PMID 27998807.
Poole LB (March 2015). "The basics of thiols and cysteines in redox biology and chemistry". Free Radical Biology & Medicine. 80: 148–57. doi:10.1016/j.freeradbiomed.2014.11.013. PMC 4355186. PMID 25433365.
Beekman AC, Woerdenbag HJ, van Uden W, Pras N, Konings AW, Wikström HV, Schmidt TJ (March 1997). "Structure-cytotoxicity relationships of some helenanolide-type sesquiterpene lactones". Journal of Natural Products. 60 (3): 252–7. doi:10.1021/np960517h. PMID 9090867.
Huang PR, Yeh YM, Wang TC (September 2005). "Potent inhibition of human telomerase by helenalin". Cancer Letters. 227 (2): 169–74. doi:10.1016/j.canlet.2004.11.045. PMID 16112419.
Chapman DE, Roberts GB, Reynolds DJ, Grippo AA, Holbrook DJ, Hall IH, Chaney SG, Chang J, Lee KH (February 1988). "Acute toxicity of helenalin in BDF1 mice". Fundamental and Applied Toxicology. 10 (2): 302–12. doi:10.1016/0272-0590(88)90315-6. PMID 3356317.
Berges C, Fuchs D, Opelz G, Daniel V, Naujokat C (September 2009). "Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms". Molecular Immunology. 46 (15): 2892–901. doi:10.1016/j.molimm.2009.07.004. PMID 19656571.
Hall IH, Starnes CO, Lee KH, Waddell TG (May 1980). "Mode of action of sesquiterpene lactones as anti-inflammatory agents". Journal of Pharmaceutical Sciences. 69 (5): 537–43. doi:10.1002/jps.2600690516. PMID 6247478.
Lee KH, Hall IH, Mar EC, Starnes CO, ElGebaly SA, Waddell TG, Hadgraft RI, Ruffner CG, Weidner I (April 1977). "Sesquiterpene antitumor agents: inhibitors of cellular metabolism". Science. 196 (4289): 533–6. Bibcode:1977Sci...196..533L. doi:10.1126/science.191909. PMID 191909.
Schröder H, Lösche W, Strobach H, Leven W, Willuhn G, Till U, Schrör K (March 1990). "Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways". Thrombosis Research. 57 (6): 839–45. doi:10.1016/0049-3848(90)90151-2. PMID 2116680.
Brito, N; Knipschild, P; Doreste-Alonso, J (2014). "Systematic Review on the Efficacy of Topical Arnica montanafor the Treatment of Pain, Swelling and Bruises". Journal of Musculoskeletal Pain. 22 (2): 216–223. doi:10.3109/10582452.2014.883012. S2CID 76330596.
Hall IH, Lee KH, Starnes CO, Muraoka O, Sumida Y, Waddell TG (June 1980). "Antihyperlipidemic activity of sesquiterpene lactones and related compounds". Journal of Pharmaceutical Sciences. 69 (6): 694–7. doi:10.1002/jps.2600690622. PMID 7205585.
Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R (1994). "Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues". Cancer Chemotherapy and Pharmacology. 34 (4): 344–50. doi:10.1007/BF00686043. PMID 8033301. S2CID 22818483.
Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I (December 1998). "The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65". The Journal of Biological Chemistry. 273 (50): 33508–16. doi:10.1074/jbc.273.50.33508. PMID 9837931.
Jimenez-Ortiz V, Brengio SD, Giordano O, Tonn C, Sánchez M, Burgos MH, Sosa MA, et al. (February 2005). "The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes". The Journal of Parasitology. 91 (1): 170–4. doi:10.1645/GE-3373. PMID 15856894. S2CID 42378778.
Schmidt TJ, Brun R, Willuhn G, Khalid SA (August 2002). "Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones". Planta Medica. 68 (8): 750–1. doi:10.1055/s-2002-33799. PMID 12221603.
François G, Passreiter CM (February 2004). "Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum". Phytotherapy Research. 18 (2): 184–6. doi:10.1002/ptr.1376. PMID 15022176. S2CID 3048612.
Boulanger D, Brouillette E, Jaspar F, Malouin F, Mainil J, Bureau F, Lekeux P, et al. (January 2007). "Helenalin reduces Staphylococcus aureus infection in vitro and in vivo". Veterinary Microbiology. 119 (2–4): 330–8. doi:10.1016/j.vetmic.2006.08.020. PMID 17010538.

harvard.edu

ui.adsabs.harvard.edu

Lee KH, Hall IH, Mar EC, Starnes CO, ElGebaly SA, Waddell TG, Hadgraft RI, Ruffner CG, Weidner I (April 1977). "Sesquiterpene antitumor agents: inhibitors of cellular metabolism". Science. 196 (4289): 533–6. Bibcode:1977Sci...196..533L. doi:10.1126/science.191909. PMID 191909.

nih.gov

pubmed.ncbi.nlm.nih.gov

Perry NB, Burgess EJ, Rodríguez Guitián MA, Romero Franco R, López Mosquera E, Smallfield BM, Joyce NI, Littlejohn RP (May 2009). "Sesquiterpene lactones in Arnica montana: helenalin and dihydrohelenalin chemotypes in Spain". Planta Medica. 75 (6): 660–6. doi:10.1055/s-0029-1185362. PMID 19235681.
Tornhamre, Susanne; Schmidt, Thomas J.; Näsman-Glaser, Barbro; Ericsson, Inger; Lindgren, Jan Åke (2001). "Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C 4 synthase in human blood cells". Biochemical Pharmacology. 62 (7): 903–911. doi:10.1016/S0006-2952(01)00729-8. PMID 11543725.
Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA (February 2018). "Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles". ChemMedChem. 13 (4): 303–311. doi:10.1002/cmdc.201700752. PMC 5894512. PMID 29349898.
Zwicker P, Schultze N, Niehs S, Albrecht D, Methling K, Wurster M, Wachlin G, Lalk M, Lindequist U, Haertel B (April 2017). "Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types". Toxicology in Vitro. 40: 45–54. doi:10.1016/j.tiv.2016.12.010. PMID 27998807.
Poole LB (March 2015). "The basics of thiols and cysteines in redox biology and chemistry". Free Radical Biology & Medicine. 80: 148–57. doi:10.1016/j.freeradbiomed.2014.11.013. PMC 4355186. PMID 25433365.
Beekman AC, Woerdenbag HJ, van Uden W, Pras N, Konings AW, Wikström HV, Schmidt TJ (March 1997). "Structure-cytotoxicity relationships of some helenanolide-type sesquiterpene lactones". Journal of Natural Products. 60 (3): 252–7. doi:10.1021/np960517h. PMID 9090867.
Huang PR, Yeh YM, Wang TC (September 2005). "Potent inhibition of human telomerase by helenalin". Cancer Letters. 227 (2): 169–74. doi:10.1016/j.canlet.2004.11.045. PMID 16112419.
Chapman DE, Roberts GB, Reynolds DJ, Grippo AA, Holbrook DJ, Hall IH, Chaney SG, Chang J, Lee KH (February 1988). "Acute toxicity of helenalin in BDF1 mice". Fundamental and Applied Toxicology. 10 (2): 302–12. doi:10.1016/0272-0590(88)90315-6. PMID 3356317.
Berges C, Fuchs D, Opelz G, Daniel V, Naujokat C (September 2009). "Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms". Molecular Immunology. 46 (15): 2892–901. doi:10.1016/j.molimm.2009.07.004. PMID 19656571.
Hall IH, Starnes CO, Lee KH, Waddell TG (May 1980). "Mode of action of sesquiterpene lactones as anti-inflammatory agents". Journal of Pharmaceutical Sciences. 69 (5): 537–43. doi:10.1002/jps.2600690516. PMID 6247478.
Lee KH, Hall IH, Mar EC, Starnes CO, ElGebaly SA, Waddell TG, Hadgraft RI, Ruffner CG, Weidner I (April 1977). "Sesquiterpene antitumor agents: inhibitors of cellular metabolism". Science. 196 (4289): 533–6. Bibcode:1977Sci...196..533L. doi:10.1126/science.191909. PMID 191909.
Schröder H, Lösche W, Strobach H, Leven W, Willuhn G, Till U, Schrör K (March 1990). "Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways". Thrombosis Research. 57 (6): 839–45. doi:10.1016/0049-3848(90)90151-2. PMID 2116680.
Hall IH, Lee KH, Starnes CO, Muraoka O, Sumida Y, Waddell TG (June 1980). "Antihyperlipidemic activity of sesquiterpene lactones and related compounds". Journal of Pharmaceutical Sciences. 69 (6): 694–7. doi:10.1002/jps.2600690622. PMID 7205585.
Witzel DA, Ivie W, Dollahite JW (July 1976). "Mammalian toxicity of helenalin, the toxic principle of Helenium microcephalum CD (smallhead sneezeweed)". American Journal of Veterinary Research. 37 (7): 859–61. PMID 937811.
Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R (1994). "Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues". Cancer Chemotherapy and Pharmacology. 34 (4): 344–50. doi:10.1007/BF00686043. PMID 8033301. S2CID 22818483.
Lyss G, Knorre A, Schmidt TJ, Pahl HL, Merfort I (December 1998). "The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65". The Journal of Biological Chemistry. 273 (50): 33508–16. doi:10.1074/jbc.273.50.33508. PMID 9837931.
Jimenez-Ortiz V, Brengio SD, Giordano O, Tonn C, Sánchez M, Burgos MH, Sosa MA, et al. (February 2005). "The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes". The Journal of Parasitology. 91 (1): 170–4. doi:10.1645/GE-3373. PMID 15856894. S2CID 42378778.
Schmidt TJ, Brun R, Willuhn G, Khalid SA (August 2002). "Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones". Planta Medica. 68 (8): 750–1. doi:10.1055/s-2002-33799. PMID 12221603.
François G, Passreiter CM (February 2004). "Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum". Phytotherapy Research. 18 (2): 184–6. doi:10.1002/ptr.1376. PMID 15022176. S2CID 3048612.
Boulanger D, Brouillette E, Jaspar F, Malouin F, Mainil J, Bureau F, Lekeux P, et al. (January 2007). "Helenalin reduces Staphylococcus aureus infection in vitro and in vivo". Veterinary Microbiology. 119 (2–4): 330–8. doi:10.1016/j.vetmic.2006.08.020. PMID 17010538.

ncbi.nlm.nih.gov

Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA (February 2018). "Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles". ChemMedChem. 13 (4): 303–311. doi:10.1002/cmdc.201700752. PMC 5894512. PMID 29349898.
Poole LB (March 2015). "The basics of thiols and cysteines in redox biology and chemistry". Free Radical Biology & Medicine. 80: 148–57. doi:10.1016/j.freeradbiomed.2014.11.013. PMC 4355186. PMID 25433365.

semanticscholar.org

api.semanticscholar.org

Brito, N; Knipschild, P; Doreste-Alonso, J (2014). "Systematic Review on the Efficacy of Topical Arnica montanafor the Treatment of Pain, Swelling and Bruises". Journal of Musculoskeletal Pain. 22 (2): 216–223. doi:10.3109/10582452.2014.883012. S2CID 76330596.
Powis G, Gallegos A, Abraham RT, Ashendel CL, Zalkow LH, Grindey GB, Bonjouklian R (1994). "Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues". Cancer Chemotherapy and Pharmacology. 34 (4): 344–50. doi:10.1007/BF00686043. PMID 8033301. S2CID 22818483.
Jimenez-Ortiz V, Brengio SD, Giordano O, Tonn C, Sánchez M, Burgos MH, Sosa MA, et al. (February 2005). "The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes". The Journal of Parasitology. 91 (1): 170–4. doi:10.1645/GE-3373. PMID 15856894. S2CID 42378778.
François G, Passreiter CM (February 2004). "Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum". Phytotherapy Research. 18 (2): 184–6. doi:10.1002/ptr.1376. PMID 15022176. S2CID 3048612.