Integrin beta 6 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Integrin beta 6" in English language version.

refsWebsite

Global rank English rank

84nih.gov

4^th place

52doi.org

2^nd place

11semanticscholar.org

11^th place

8^th place

3harvard.edu

18^th place

17^th place

2ensembl.org

1,626^th place

1,007^th place

doi.org

Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, et al. (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173. S2CID 13363937.
Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, et al. (March 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". The Journal of Biological Chemistry. 269 (9): 6940–8. doi:10.1016/S0021-9258(17)37465-3. PMID 8120056.
Hynes RO (September 2002). "Integrins: bidirectional, allosteric signaling machines". Cell. 110 (6): 673–87. doi:10.1016/s0092-8674(02)00971-6. PMID 12297042. S2CID 30326350.
Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R (July 1990). "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction". The Journal of Biological Chemistry. 265 (20): 11502–7. doi:10.1016/S0021-9258(19)38425-X. PMID 2365683.
Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, et al. (1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173. S2CID 13363937.
Xu M, Chen X, Yin H, Yin L, Liu F, Fu Y, et al. (2015). "Cloning and characterization of the human integrin β6 gene promoter". PLOS ONE. 10 (3): e0121439. Bibcode:2015PLoSO..1021439X. doi:10.1371/journal.pone.0121439. PMC 4376883. PMID 25816241.
Azare J, Leslie K, Al-Ahmadie H, Gerald W, Weinreb PH, Violette SM, Bromberg J (June 2007). "Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6". Molecular and Cellular Biology. 27 (12): 4444–53. doi:10.1128/MCB.02404-06. PMC 1900039. PMID 17438134.
Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, et al. (February 2005). "Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma". The Journal of Clinical Investigation. 115 (2): 339–47. doi:10.1172/JCI23183. PMC 544606. PMID 15668738.
Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, et al. (April 2016). "Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression". The Journal of Biological Chemistry. 291 (18): 9540–53. doi:10.1074/jbc.M115.692368. PMC 4850293. PMID 26861876.
Xu M, Yin L, Cai Y, Hu Q, Huang J, Ji Q, et al. (May 2018). "Epigenetic regulation of integrin β6 transcription induced by TGF-β1 in human oral squamous cell carcinoma cells". Journal of Cellular Biochemistry. 119 (5): 4193–4204. doi:10.1002/jcb.26642. PMID 29274289. S2CID 4330899.
Graff JR, Zimmer SG (2003). "Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs". Clinical & Experimental Metastasis. 20 (3): 265–73. doi:10.1023/A:1022943419011. PMID 12741684. S2CID 21561578.
Enyu L, Zhengchuan N, Jiayong W, Benjia L, Qi S, Ruixi Q, et al. (August 2015). "Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy". Tumour Biology. 36 (8): 6541–50. doi:10.1007/s13277-015-3348-8. PMID 25982998. S2CID 2656185.
Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, et al. (May 1996). "Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin". The Journal of Cell Biology. 133 (4): 921–8. doi:10.1083/jcb.133.4.921. PMC 2120829. PMID 8666675.
Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. (February 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis". Cell. 96 (3): 319–28. doi:10.1016/s0092-8674(00)80545-0. PMID 10025398.
Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, et al. (April 2005). "Characterization of integrin beta6 and thrombospondin-1 double-null mice". Journal of Cellular and Molecular Medicine. 9 (2): 421–37. doi:10.1111/j.1582-4934.2005.tb00367.x. PMC 6740207. PMID 15963261.
Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, et al. (March 2003). "Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema". Nature. 422 (6928): 169–73. Bibcode:2003Natur.422..169M. doi:10.1038/nature01413. PMID 12634787. S2CID 4407206.
Ghannad F, Nica D, Fulle MI, Grenier D, Putnins EE, Johnston S, et al. (May 2008). "Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease". The American Journal of Pathology. 172 (5): 1271–86. doi:10.2353/ajpath.2008.071068. PMC 2329836. PMID 18385522.
Bi J, Koivisto L, Pang A, Li M, Jiang G, Aurora S, et al. (June 2017). "Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells". Scientific Reports. 7 (1): 4411. Bibcode:2017NatSR...7.4411B. doi:10.1038/s41598-017-03619-7. PMC 5493688. PMID 28667248.
Mohazab L, Koivisto L, Jiang G, Kytömäki L, Haapasalo M, Owen GR, et al. (February 2013). "Critical role for αvβ6 integrin in enamel biomineralization". Journal of Cell Science. 126 (Pt 3): 732–44. doi:10.1242/jcs.112599. PMID 23264742.
Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, et al. (June 1995). "Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling". Journal of Cell Science. 108 ( Pt 6) (6): 2241–51. doi:10.1242/jcs.108.6.2241. PMID 7673344.
Haapasalmi K, Zhang K, Tonnesen M, Olerud J, Sheppard D, Salo T, et al. (January 1996). "Keratinocytes in human wounds express alpha v beta 6 integrin". The Journal of Investigative Dermatology. 106 (1): 42–8. doi:10.1111/1523-1747.ep12327199. PMID 8592080.
Eslami A, Gallant-Behm CL, Hart DA, Wiebe C, Honardoust D, Gardner H, et al. (June 2009). "Expression of integrin alphavbeta6 and TGF-beta in scarless vs scar-forming wound healing". The Journal of Histochemistry and Cytochemistry. 57 (6): 543–57. doi:10.1369/jhc.2009.952572. PMC 2690407. PMID 19223298.
Bandyopadhyay A, Raghavan S (July 2009). "Defining the role of integrin alphavbeta6 in cancer". Current Drug Targets. 10 (7): 645–52. doi:10.2174/138945009788680374. PMC 2888263. PMID 19601768.
Annes JP, Chen Y, Munger JS, Rifkin DB (June 2004). "Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1". The Journal of Cell Biology. 165 (5): 723–34. doi:10.1083/jcb.200312172. PMC 2172370. PMID 15184403.
Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA (June 2011). "Latent TGF-β structure and activation". Nature. 474 (7351): 343–9. doi:10.1038/nature10152. PMC 4717672. PMID 21677751.
Syed V (June 2016). "TGF-β Signaling in Cancer". Journal of Cellular Biochemistry. 117 (6): 1279–87. doi:10.1002/jcb.25496. PMID 26774024. S2CID 18884315.
Massagué J (October 2012). "TGFβ signalling in context". Nature Reviews. Molecular Cell Biology. 13 (10): 616–30. doi:10.1038/nrm3434. PMC 4027049. PMID 22992590.
Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P (May 2009). "Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis". Journal of Cellular Physiology. 219 (2): 449–58. doi:10.1002/jcp.21706. PMC 2749291. PMID 19180561.
Xu J, Lamouille S, Derynck R (February 2009). "TGF-beta-induced epithelial to mesenchymal transition". Cell Research. 19 (2): 156–72. doi:10.1038/cr.2009.5. PMC 4720263. PMID 19153598.
Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006). "Transforming growth factor-beta regulation of immune responses". Annual Review of Immunology. 24: 99–146. doi:10.1146/annurev.immunol.24.021605.090737. PMID 16551245.
Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (September 2008). "Growth factors and cytokines in wound healing". Wound Repair and Regeneration. 16 (5): 585–601. doi:10.1111/j.1524-475X.2008.00410.x. PMID 19128254. S2CID 12369824.
King TE, Pardo A, Selman M (December 2011). "Idiopathic pulmonary fibrosis". Lancet. 378 (9807): 1949–61. doi:10.1016/S0140-6736(11)60052-4. PMID 21719092. S2CID 6658229.
Chen H, Yang WW, Wen QT, Xu L, Chen M (December 2009). "TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM [corrected]". Experimental and Molecular Pathology. 87 (3): 189–94. doi:10.1016/j.yexmp.2009.09.001. PMID 19747910.
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, et al. (July 2009). "In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery". Journal of Virology. 83 (13): 6416–28. doi:10.1128/JVI.00445-09. PMC 2698540. PMID 19369326.
Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF (June 2004). "The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9". The Journal of Biological Chemistry. 279 (25): 26533–9. doi:10.1074/jbc.M401736200. PMID 15067014.
Ahmed N, Niu J, Dorahy DJ, Gu X, Andrews S, Meldrum CJ, et al. (February 2002). "Direct integrin alphavbeta6-ERK binding: implications for tumour growth". Oncogene. 21 (9): 1370–80. doi:10.1038/sj.onc.1205286. PMID 11857080. S2CID 29988894.
Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, Steadman R (May 2013). "Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts". The Journal of Biological Chemistry. 288 (21): 14824–38. doi:10.1074/jbc.M113.451336. PMC 3663506. PMID 23589287.
Kalluri R, Weinberg RA (June 2009). "The basics of epithelial-mesenchymal transition". The Journal of Clinical Investigation. 119 (6): 1420–8. doi:10.1172/JCI39104. PMC 2689101. PMID 19487818.
Bates RC, Mercurio AM (April 2005). "The epithelial-mesenchymal transition (EMT) and colorectal cancer progression". Cancer Biology & Therapy. 4 (4): 365–70. doi:10.4161/cbt.4.4.1655. PMID 15846061.
Wang SK, Choi M, Richardson AS, Reid BM, Lin BP, Wang SJ, et al. (April 2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
Poulter JA, Brookes SJ, Shore RC, Smith CE, Abi Farraj L, Kirkham J, et al. (April 2014). "A missense mutation in ITGB6 causes pitted hypomineralized amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2189–97. doi:10.1093/hmg/ddt616. PMC 3959822. PMID 24319098.
Ansar M, Jan A, Santos-Cortez RL, Wang X, Suliman M, Acharya A, et al. (August 2016). "Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability". European Journal of Human Genetics. 24 (8): 1223–7. doi:10.1038/ejhg.2015.260. PMC 4970676. PMID 26695873.
Kossatz S, Beer AJ, Notni J (October 2021). "It's Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals". Cancers. 13 (23): 5985. doi:10.3390/cancers13235958. PMC 8657165. PMID 34885066.
Kimura RH, Iagaru A, Guo HH (October 2023). "Mini review of first-in-human integrin αvβ6 PET tracers". Frontiers in Nuclear Medicine. 9 (3): 1271208. doi:10.3389/fnume.2023.1271208. PMC 11440954. PMID 39355045.
Quigley NG, Steiger K, Hoberueck S, Czech N, Zierke MA, Kossatz S, et al. (March 2022). "PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin". European Journal of Nuclear Medicine and Molecular Imaging. 49 (4): 1136–1147. doi:10.1007/s00259-021-05559-x. PMC 8460406. PMID 34559266.
Rehm J, Winzer R, Pretze M, Mueller J, Notni J, Hempel S, et al. (November 2024). "αvβ6-integrin targeted PET/CT imaging in pancreatic cancer patients using ⁶⁸Ga-Trivehexin". Frontiers in Nuclear Medicine. 15 (4): 148602. doi:10.3389/fnume.2024.1487602. PMC 11604418. PMID 39618940.
Quigley NG, Czech N, Sendt W, Notni J (June 2021). "PET/CT imaging of pancreatic carcinoma targeting the "cancer integrin" αvβ6". European Journal of Nuclear Medicine and Molecular Imaging. 48 (12): 4107–4108. doi:10.1007/s00259-021-05443-8. PMC 8484182. PMID 34109438.
Rehm J, Winzer R, Notni J, Hempel S, Distler M, Folprecht G, et al. (September 2024). "Concomitant metastatic head-and-neck cancer and pancreatic cancer assessed by αvβ6-integrin PET/CT using ⁶⁸Ga-Trivehexin: incidental detection of a brain metastasis". European Journal of Nuclear Medicine and Molecular Imaging. 51 (11): 3469–3471. doi:10.1007/s00259-024-06750-6. PMC 11368998. PMID 38771514.
Wu H, Li L, Xiao Z, Li C, He Y (November 2024). "αvβ6-integrin targeted [⁶⁸Ga]Ga-Trivehexin PET/CT imaging of a rare bronchial mucoepidermoid carcinoma". European Journal of Nuclear Medicine and Molecular Imaging. doi:10.1007/s00259-024-06974-6. PMID 39500808.
Kuyumcu S, Denizmen D, Has-Simsek D, Poyanli A, Uzum AK, Buyukkaya F, et al. (July 2024). "⁶⁸Ga-Trivehexin PET/CT: a promising novel tracer for primary hyperparathyroidism". European Journal of Nuclear Medicine and Molecular Imaging. 51 (13): 3912–3923. doi:10.1007/s00259-024-06846-z. PMC 11527967. PMID 39028425.
Singhal T, Agrawal K, Mandal S, Parida GK (November 2024). "Cancer-Specific Integrin Imaging With ⁶⁸Ga-Trivehexin: A Potential Imaging for Accurate Staging of Thyroid Malignancy". Clinical Nuclear Medicine. doi:10.1097/RLU.0000000000005557. PMID 39499025.
Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, et al. (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". The Journal of Biological Chemistry. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000115221 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026971 – Ensembl, May 2017

harvard.edu

ui.adsabs.harvard.edu

Xu M, Chen X, Yin H, Yin L, Liu F, Fu Y, et al. (2015). "Cloning and characterization of the human integrin β6 gene promoter". PLOS ONE. 10 (3): e0121439. Bibcode:2015PLoSO..1021439X. doi:10.1371/journal.pone.0121439. PMC 4376883. PMID 25816241.
Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, et al. (March 2003). "Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema". Nature. 422 (6928): 169–73. Bibcode:2003Natur.422..169M. doi:10.1038/nature01413. PMID 12634787. S2CID 4407206.
Bi J, Koivisto L, Pang A, Li M, Jiang G, Aurora S, et al. (June 2017). "Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells". Scientific Reports. 7 (1): 4411. Bibcode:2017NatSR...7.4411B. doi:10.1038/s41598-017-03619-7. PMC 5493688. PMID 28667248.

nih.gov

pubmed.ncbi.nlm.nih.gov

Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, et al. (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173. S2CID 13363937.
Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, et al. (March 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". The Journal of Biological Chemistry. 269 (9): 6940–8. doi:10.1016/S0021-9258(17)37465-3. PMID 8120056.
Hynes RO (September 2002). "Integrins: bidirectional, allosteric signaling machines". Cell. 110 (6): 673–87. doi:10.1016/s0092-8674(02)00971-6. PMID 12297042. S2CID 30326350.
Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R (July 1990). "Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction". The Journal of Biological Chemistry. 265 (20): 11502–7. doi:10.1016/S0021-9258(19)38425-X. PMID 2365683.
Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, et al. (1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173. S2CID 13363937.
Xu M, Chen X, Yin H, Yin L, Liu F, Fu Y, et al. (2015). "Cloning and characterization of the human integrin β6 gene promoter". PLOS ONE. 10 (3): e0121439. Bibcode:2015PLoSO..1021439X. doi:10.1371/journal.pone.0121439. PMC 4376883. PMID 25816241.
Azare J, Leslie K, Al-Ahmadie H, Gerald W, Weinreb PH, Violette SM, Bromberg J (June 2007). "Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6". Molecular and Cellular Biology. 27 (12): 4444–53. doi:10.1128/MCB.02404-06. PMC 1900039. PMID 17438134.
Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, et al. (February 2005). "Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma". The Journal of Clinical Investigation. 115 (2): 339–47. doi:10.1172/JCI23183. PMC 544606. PMID 15668738.
Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, et al. (April 2016). "Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression". The Journal of Biological Chemistry. 291 (18): 9540–53. doi:10.1074/jbc.M115.692368. PMC 4850293. PMID 26861876.
Xu M, Yin L, Cai Y, Hu Q, Huang J, Ji Q, et al. (May 2018). "Epigenetic regulation of integrin β6 transcription induced by TGF-β1 in human oral squamous cell carcinoma cells". Journal of Cellular Biochemistry. 119 (5): 4193–4204. doi:10.1002/jcb.26642. PMID 29274289. S2CID 4330899.
Graff JR, Zimmer SG (2003). "Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs". Clinical & Experimental Metastasis. 20 (3): 265–73. doi:10.1023/A:1022943419011. PMID 12741684. S2CID 21561578.
Enyu L, Zhengchuan N, Jiayong W, Benjia L, Qi S, Ruixi Q, et al. (August 2015). "Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy". Tumour Biology. 36 (8): 6541–50. doi:10.1007/s13277-015-3348-8. PMID 25982998. S2CID 2656185.
Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, et al. (May 1996). "Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin". The Journal of Cell Biology. 133 (4): 921–8. doi:10.1083/jcb.133.4.921. PMC 2120829. PMID 8666675.
Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. (February 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis". Cell. 96 (3): 319–28. doi:10.1016/s0092-8674(00)80545-0. PMID 10025398.
Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, et al. (April 2005). "Characterization of integrin beta6 and thrombospondin-1 double-null mice". Journal of Cellular and Molecular Medicine. 9 (2): 421–37. doi:10.1111/j.1582-4934.2005.tb00367.x. PMC 6740207. PMID 15963261.
Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, et al. (March 2003). "Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema". Nature. 422 (6928): 169–73. Bibcode:2003Natur.422..169M. doi:10.1038/nature01413. PMID 12634787. S2CID 4407206.
Ghannad F, Nica D, Fulle MI, Grenier D, Putnins EE, Johnston S, et al. (May 2008). "Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease". The American Journal of Pathology. 172 (5): 1271–86. doi:10.2353/ajpath.2008.071068. PMC 2329836. PMID 18385522.
Bi J, Koivisto L, Pang A, Li M, Jiang G, Aurora S, et al. (June 2017). "Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells". Scientific Reports. 7 (1): 4411. Bibcode:2017NatSR...7.4411B. doi:10.1038/s41598-017-03619-7. PMC 5493688. PMID 28667248.
Mohazab L, Koivisto L, Jiang G, Kytömäki L, Haapasalo M, Owen GR, et al. (February 2013). "Critical role for αvβ6 integrin in enamel biomineralization". Journal of Cell Science. 126 (Pt 3): 732–44. doi:10.1242/jcs.112599. PMID 23264742.
Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, et al. (June 1995). "Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling". Journal of Cell Science. 108 ( Pt 6) (6): 2241–51. doi:10.1242/jcs.108.6.2241. PMID 7673344.
Haapasalmi K, Zhang K, Tonnesen M, Olerud J, Sheppard D, Salo T, et al. (January 1996). "Keratinocytes in human wounds express alpha v beta 6 integrin". The Journal of Investigative Dermatology. 106 (1): 42–8. doi:10.1111/1523-1747.ep12327199. PMID 8592080.
Eslami A, Gallant-Behm CL, Hart DA, Wiebe C, Honardoust D, Gardner H, et al. (June 2009). "Expression of integrin alphavbeta6 and TGF-beta in scarless vs scar-forming wound healing". The Journal of Histochemistry and Cytochemistry. 57 (6): 543–57. doi:10.1369/jhc.2009.952572. PMC 2690407. PMID 19223298.
Bandyopadhyay A, Raghavan S (July 2009). "Defining the role of integrin alphavbeta6 in cancer". Current Drug Targets. 10 (7): 645–52. doi:10.2174/138945009788680374. PMC 2888263. PMID 19601768.
Annes JP, Chen Y, Munger JS, Rifkin DB (June 2004). "Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1". The Journal of Cell Biology. 165 (5): 723–34. doi:10.1083/jcb.200312172. PMC 2172370. PMID 15184403.
Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA (June 2011). "Latent TGF-β structure and activation". Nature. 474 (7351): 343–9. doi:10.1038/nature10152. PMC 4717672. PMID 21677751.
Syed V (June 2016). "TGF-β Signaling in Cancer". Journal of Cellular Biochemistry. 117 (6): 1279–87. doi:10.1002/jcb.25496. PMID 26774024. S2CID 18884315.
Massagué J (October 2012). "TGFβ signalling in context". Nature Reviews. Molecular Cell Biology. 13 (10): 616–30. doi:10.1038/nrm3434. PMC 4027049. PMID 22992590.
Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P (May 2009). "Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis". Journal of Cellular Physiology. 219 (2): 449–58. doi:10.1002/jcp.21706. PMC 2749291. PMID 19180561.
Xu J, Lamouille S, Derynck R (February 2009). "TGF-beta-induced epithelial to mesenchymal transition". Cell Research. 19 (2): 156–72. doi:10.1038/cr.2009.5. PMC 4720263. PMID 19153598.
Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006). "Transforming growth factor-beta regulation of immune responses". Annual Review of Immunology. 24: 99–146. doi:10.1146/annurev.immunol.24.021605.090737. PMID 16551245.
Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (September 2008). "Growth factors and cytokines in wound healing". Wound Repair and Regeneration. 16 (5): 585–601. doi:10.1111/j.1524-475X.2008.00410.x. PMID 19128254. S2CID 12369824.
King TE, Pardo A, Selman M (December 2011). "Idiopathic pulmonary fibrosis". Lancet. 378 (9807): 1949–61. doi:10.1016/S0140-6736(11)60052-4. PMID 21719092. S2CID 6658229.
Chen H, Yang WW, Wen QT, Xu L, Chen M (December 2009). "TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM [corrected]". Experimental and Molecular Pathology. 87 (3): 189–94. doi:10.1016/j.yexmp.2009.09.001. PMID 19747910.
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, et al. (July 2009). "In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery". Journal of Virology. 83 (13): 6416–28. doi:10.1128/JVI.00445-09. PMC 2698540. PMID 19369326.
Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF (June 2004). "The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9". The Journal of Biological Chemistry. 279 (25): 26533–9. doi:10.1074/jbc.M401736200. PMID 15067014.
Ahmed N, Niu J, Dorahy DJ, Gu X, Andrews S, Meldrum CJ, et al. (February 2002). "Direct integrin alphavbeta6-ERK binding: implications for tumour growth". Oncogene. 21 (9): 1370–80. doi:10.1038/sj.onc.1205286. PMID 11857080. S2CID 29988894.
Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, Steadman R (May 2013). "Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts". The Journal of Biological Chemistry. 288 (21): 14824–38. doi:10.1074/jbc.M113.451336. PMC 3663506. PMID 23589287.
Kalluri R, Weinberg RA (June 2009). "The basics of epithelial-mesenchymal transition". The Journal of Clinical Investigation. 119 (6): 1420–8. doi:10.1172/JCI39104. PMC 2689101. PMID 19487818.
Ramos DM, Dang D, Sadler S (January 2009). "The role of the integrin alpha v beta6 in regulating the epithelial to mesenchymal transition in oral cancer". Anticancer Research. 29 (1): 125–30. PMID 19331141.
Bates RC, Mercurio AM (April 2005). "The epithelial-mesenchymal transition (EMT) and colorectal cancer progression". Cancer Biology & Therapy. 4 (4): 365–70. doi:10.4161/cbt.4.4.1655. PMID 15846061.
Wang SK, Choi M, Richardson AS, Reid BM, Lin BP, Wang SJ, et al. (April 2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
Poulter JA, Brookes SJ, Shore RC, Smith CE, Abi Farraj L, Kirkham J, et al. (April 2014). "A missense mutation in ITGB6 causes pitted hypomineralized amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2189–97. doi:10.1093/hmg/ddt616. PMC 3959822. PMID 24319098.
Ansar M, Jan A, Santos-Cortez RL, Wang X, Suliman M, Acharya A, et al. (August 2016). "Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability". European Journal of Human Genetics. 24 (8): 1223–7. doi:10.1038/ejhg.2015.260. PMC 4970676. PMID 26695873.
Kossatz S, Beer AJ, Notni J (October 2021). "It's Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals". Cancers. 13 (23): 5985. doi:10.3390/cancers13235958. PMC 8657165. PMID 34885066.
Kimura RH, Iagaru A, Guo HH (October 2023). "Mini review of first-in-human integrin αvβ6 PET tracers". Frontiers in Nuclear Medicine. 9 (3): 1271208. doi:10.3389/fnume.2023.1271208. PMC 11440954. PMID 39355045.
Quigley NG, Steiger K, Hoberueck S, Czech N, Zierke MA, Kossatz S, et al. (March 2022). "PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin". European Journal of Nuclear Medicine and Molecular Imaging. 49 (4): 1136–1147. doi:10.1007/s00259-021-05559-x. PMC 8460406. PMID 34559266.
Rehm J, Winzer R, Pretze M, Mueller J, Notni J, Hempel S, et al. (November 2024). "αvβ6-integrin targeted PET/CT imaging in pancreatic cancer patients using ⁶⁸Ga-Trivehexin". Frontiers in Nuclear Medicine. 15 (4): 148602. doi:10.3389/fnume.2024.1487602. PMC 11604418. PMID 39618940.
Quigley NG, Czech N, Sendt W, Notni J (June 2021). "PET/CT imaging of pancreatic carcinoma targeting the "cancer integrin" αvβ6". European Journal of Nuclear Medicine and Molecular Imaging. 48 (12): 4107–4108. doi:10.1007/s00259-021-05443-8. PMC 8484182. PMID 34109438.
Rehm J, Winzer R, Notni J, Hempel S, Distler M, Folprecht G, et al. (September 2024). "Concomitant metastatic head-and-neck cancer and pancreatic cancer assessed by αvβ6-integrin PET/CT using ⁶⁸Ga-Trivehexin: incidental detection of a brain metastasis". European Journal of Nuclear Medicine and Molecular Imaging. 51 (11): 3469–3471. doi:10.1007/s00259-024-06750-6. PMC 11368998. PMID 38771514.
Wu H, Li L, Xiao Z, Li C, He Y (November 2024). "αvβ6-integrin targeted [⁶⁸Ga]Ga-Trivehexin PET/CT imaging of a rare bronchial mucoepidermoid carcinoma". European Journal of Nuclear Medicine and Molecular Imaging. doi:10.1007/s00259-024-06974-6. PMID 39500808.
Kuyumcu S, Denizmen D, Has-Simsek D, Poyanli A, Uzum AK, Buyukkaya F, et al. (July 2024). "⁶⁸Ga-Trivehexin PET/CT: a promising novel tracer for primary hyperparathyroidism". European Journal of Nuclear Medicine and Molecular Imaging. 51 (13): 3912–3923. doi:10.1007/s00259-024-06846-z. PMC 11527967. PMID 39028425.
Singhal T, Agrawal K, Mandal S, Parida GK (November 2024). "Cancer-Specific Integrin Imaging With ⁶⁸Ga-Trivehexin: A Potential Imaging for Accurate Staging of Thyroid Malignancy". Clinical Nuclear Medicine. doi:10.1097/RLU.0000000000005557. PMID 39499025.
Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, et al. (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". The Journal of Biological Chemistry. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ITGB6 integrin, beta 6".
Xu M, Chen X, Yin H, Yin L, Liu F, Fu Y, et al. (2015). "Cloning and characterization of the human integrin β6 gene promoter". PLOS ONE. 10 (3): e0121439. Bibcode:2015PLoSO..1021439X. doi:10.1371/journal.pone.0121439. PMC 4376883. PMID 25816241.
Azare J, Leslie K, Al-Ahmadie H, Gerald W, Weinreb PH, Violette SM, Bromberg J (June 2007). "Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6". Molecular and Cellular Biology. 27 (12): 4444–53. doi:10.1128/MCB.02404-06. PMC 1900039. PMID 17438134.
Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, et al. (February 2005). "Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma". The Journal of Clinical Investigation. 115 (2): 339–47. doi:10.1172/JCI23183. PMC 544606. PMID 15668738.
Tatler AL, Habgood A, Porte J, John AE, Stavrou A, Hodge E, et al. (April 2016). "Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression". The Journal of Biological Chemistry. 291 (18): 9540–53. doi:10.1074/jbc.M115.692368. PMC 4850293. PMID 26861876.
Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, et al. (May 1996). "Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin". The Journal of Cell Biology. 133 (4): 921–8. doi:10.1083/jcb.133.4.921. PMC 2120829. PMID 8666675.
Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, et al. (April 2005). "Characterization of integrin beta6 and thrombospondin-1 double-null mice". Journal of Cellular and Molecular Medicine. 9 (2): 421–37. doi:10.1111/j.1582-4934.2005.tb00367.x. PMC 6740207. PMID 15963261.
Ghannad F, Nica D, Fulle MI, Grenier D, Putnins EE, Johnston S, et al. (May 2008). "Absence of alphavbeta6 integrin is linked to initiation and progression of periodontal disease". The American Journal of Pathology. 172 (5): 1271–86. doi:10.2353/ajpath.2008.071068. PMC 2329836. PMID 18385522.
Bi J, Koivisto L, Pang A, Li M, Jiang G, Aurora S, et al. (June 2017). "Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells". Scientific Reports. 7 (1): 4411. Bibcode:2017NatSR...7.4411B. doi:10.1038/s41598-017-03619-7. PMC 5493688. PMID 28667248.
Eslami A, Gallant-Behm CL, Hart DA, Wiebe C, Honardoust D, Gardner H, et al. (June 2009). "Expression of integrin alphavbeta6 and TGF-beta in scarless vs scar-forming wound healing". The Journal of Histochemistry and Cytochemistry. 57 (6): 543–57. doi:10.1369/jhc.2009.952572. PMC 2690407. PMID 19223298.
Bandyopadhyay A, Raghavan S (July 2009). "Defining the role of integrin alphavbeta6 in cancer". Current Drug Targets. 10 (7): 645–52. doi:10.2174/138945009788680374. PMC 2888263. PMID 19601768.
Annes JP, Chen Y, Munger JS, Rifkin DB (June 2004). "Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1". The Journal of Cell Biology. 165 (5): 723–34. doi:10.1083/jcb.200312172. PMC 2172370. PMID 15184403.
Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA (June 2011). "Latent TGF-β structure and activation". Nature. 474 (7351): 343–9. doi:10.1038/nature10152. PMC 4717672. PMID 21677751.
Massagué J (October 2012). "TGFβ signalling in context". Nature Reviews. Molecular Cell Biology. 13 (10): 616–30. doi:10.1038/nrm3434. PMC 4027049. PMID 22992590.
Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P (May 2009). "Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis". Journal of Cellular Physiology. 219 (2): 449–58. doi:10.1002/jcp.21706. PMC 2749291. PMID 19180561.
Xu J, Lamouille S, Derynck R (February 2009). "TGF-beta-induced epithelial to mesenchymal transition". Cell Research. 19 (2): 156–72. doi:10.1038/cr.2009.5. PMC 4720263. PMID 19153598.
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, et al. (July 2009). "In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery". Journal of Virology. 83 (13): 6416–28. doi:10.1128/JVI.00445-09. PMC 2698540. PMID 19369326.
Midgley AC, Rogers M, Hallett MB, Clayton A, Bowen T, Phillips AO, Steadman R (May 2013). "Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts". The Journal of Biological Chemistry. 288 (21): 14824–38. doi:10.1074/jbc.M113.451336. PMC 3663506. PMID 23589287.
Kalluri R, Weinberg RA (June 2009). "The basics of epithelial-mesenchymal transition". The Journal of Clinical Investigation. 119 (6): 1420–8. doi:10.1172/JCI39104. PMC 2689101. PMID 19487818.
Wang SK, Choi M, Richardson AS, Reid BM, Lin BP, Wang SJ, et al. (April 2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
Poulter JA, Brookes SJ, Shore RC, Smith CE, Abi Farraj L, Kirkham J, et al. (April 2014). "A missense mutation in ITGB6 causes pitted hypomineralized amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2189–97. doi:10.1093/hmg/ddt616. PMC 3959822. PMID 24319098.
Ansar M, Jan A, Santos-Cortez RL, Wang X, Suliman M, Acharya A, et al. (August 2016). "Expansion of the spectrum of ITGB6-related disorders to adolescent alopecia, dentogingival abnormalities and intellectual disability". European Journal of Human Genetics. 24 (8): 1223–7. doi:10.1038/ejhg.2015.260. PMC 4970676. PMID 26695873.
Kossatz S, Beer AJ, Notni J (October 2021). "It's Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals". Cancers. 13 (23): 5985. doi:10.3390/cancers13235958. PMC 8657165. PMID 34885066.
Kimura RH, Iagaru A, Guo HH (October 2023). "Mini review of first-in-human integrin αvβ6 PET tracers". Frontiers in Nuclear Medicine. 9 (3): 1271208. doi:10.3389/fnume.2023.1271208. PMC 11440954. PMID 39355045.
Quigley NG, Steiger K, Hoberueck S, Czech N, Zierke MA, Kossatz S, et al. (March 2022). "PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin". European Journal of Nuclear Medicine and Molecular Imaging. 49 (4): 1136–1147. doi:10.1007/s00259-021-05559-x. PMC 8460406. PMID 34559266.
Rehm J, Winzer R, Pretze M, Mueller J, Notni J, Hempel S, et al. (November 2024). "αvβ6-integrin targeted PET/CT imaging in pancreatic cancer patients using ⁶⁸Ga-Trivehexin". Frontiers in Nuclear Medicine. 15 (4): 148602. doi:10.3389/fnume.2024.1487602. PMC 11604418. PMID 39618940.
Quigley NG, Czech N, Sendt W, Notni J (June 2021). "PET/CT imaging of pancreatic carcinoma targeting the "cancer integrin" αvβ6". European Journal of Nuclear Medicine and Molecular Imaging. 48 (12): 4107–4108. doi:10.1007/s00259-021-05443-8. PMC 8484182. PMID 34109438.
Rehm J, Winzer R, Notni J, Hempel S, Distler M, Folprecht G, et al. (September 2024). "Concomitant metastatic head-and-neck cancer and pancreatic cancer assessed by αvβ6-integrin PET/CT using ⁶⁸Ga-Trivehexin: incidental detection of a brain metastasis". European Journal of Nuclear Medicine and Molecular Imaging. 51 (11): 3469–3471. doi:10.1007/s00259-024-06750-6. PMC 11368998. PMID 38771514.
Kuyumcu S, Denizmen D, Has-Simsek D, Poyanli A, Uzum AK, Buyukkaya F, et al. (July 2024). "⁶⁸Ga-Trivehexin PET/CT: a promising novel tracer for primary hyperparathyroidism". European Journal of Nuclear Medicine and Molecular Imaging. 51 (13): 3912–3923. doi:10.1007/s00259-024-06846-z. PMC 11527967. PMID 39028425.

semanticscholar.org

api.semanticscholar.org

Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, et al. (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173. S2CID 13363937.
Hynes RO (September 2002). "Integrins: bidirectional, allosteric signaling machines". Cell. 110 (6): 673–87. doi:10.1016/s0092-8674(02)00971-6. PMID 12297042. S2CID 30326350.
Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, et al. (1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173. S2CID 13363937.
Xu M, Yin L, Cai Y, Hu Q, Huang J, Ji Q, et al. (May 2018). "Epigenetic regulation of integrin β6 transcription induced by TGF-β1 in human oral squamous cell carcinoma cells". Journal of Cellular Biochemistry. 119 (5): 4193–4204. doi:10.1002/jcb.26642. PMID 29274289. S2CID 4330899.
Graff JR, Zimmer SG (2003). "Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs". Clinical & Experimental Metastasis. 20 (3): 265–73. doi:10.1023/A:1022943419011. PMID 12741684. S2CID 21561578.
Enyu L, Zhengchuan N, Jiayong W, Benjia L, Qi S, Ruixi Q, et al. (August 2015). "Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy". Tumour Biology. 36 (8): 6541–50. doi:10.1007/s13277-015-3348-8. PMID 25982998. S2CID 2656185.
Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, et al. (March 2003). "Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema". Nature. 422 (6928): 169–73. Bibcode:2003Natur.422..169M. doi:10.1038/nature01413. PMID 12634787. S2CID 4407206.
Syed V (June 2016). "TGF-β Signaling in Cancer". Journal of Cellular Biochemistry. 117 (6): 1279–87. doi:10.1002/jcb.25496. PMID 26774024. S2CID 18884315.
Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (September 2008). "Growth factors and cytokines in wound healing". Wound Repair and Regeneration. 16 (5): 585–601. doi:10.1111/j.1524-475X.2008.00410.x. PMID 19128254. S2CID 12369824.
King TE, Pardo A, Selman M (December 2011). "Idiopathic pulmonary fibrosis". Lancet. 378 (9807): 1949–61. doi:10.1016/S0140-6736(11)60052-4. PMID 21719092. S2CID 6658229.
Ahmed N, Niu J, Dorahy DJ, Gu X, Andrews S, Meldrum CJ, et al. (February 2002). "Direct integrin alphavbeta6-ERK binding: implications for tumour growth". Oncogene. 21 (9): 1370–80. doi:10.1038/sj.onc.1205286. PMID 11857080. S2CID 29988894.