Clinical trial number NCT02473289 for "An Efficacy and Safety Study of Sirukumab in Participants With Major Depressive Disorder." at ClinicalTrials.gov
Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB, Ruddle FH (April 1988). "Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21". Genomics. 2 (3): 203–208. doi:10.1016/0888-7543(88)90003-1. PMID3294161.
Banks WA, Kastin AJ, Gutierrez EG (September 1994). "Penetration of interleukin-6 across the murine blood–brain barrier". Neuroscience Letters. 179 (1–2): 53–56. doi:10.1016/0304-3940(94)90933-4. PMID7845624. S2CID22712577.
Wernstedt I, Edgley A, Berndtsson A, Fäldt J, Bergström G, Wallenius V, et al. (September 2006). "Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 291 (3): R551–R557. doi:10.1152/ajpregu.00514.2005. PMID16455769.
Fäldt J, Wernstedt I, Fitzgerald SM, Wallenius K, Bergström G, Jansson JO (June 2004). "Reduced exercise endurance in interleukin-6-deficient mice". Endocrinology. 145 (6): 2680–2686. doi:10.1210/en.2003-1319. PMID14988384.
Matthews VB, Allen TL, Risis S, Chan MH, Henstridge DC, Watson N, et al. (November 2010). "Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance". Diabetologia. 53 (11): 2431–2441. doi:10.1007/s00125-010-1865-y. PMID20697689. S2CID12970519.
Di Gregorio GB, Hensley L, Lu T, Ranganathan G, Kern PA (July 2004). "Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity". American Journal of Physiology. Endocrinology and Metabolism. 287 (1): E182–E187. doi:10.1152/ajpendo.00189.2003. PMID15191885.
Wallenius K, Wallenius V, Sunter D, Dickson SL, Jansson JO (April 2002). "Intracerebroventricular interleukin-6 treatment decreases body fat in rats". Biochemical and Biophysical Research Communications. 293 (1): 560–565. doi:10.1016/S0006-291X(02)00230-9. PMID12054638.
Anesten F, Mishra D, Dalmau Gasull A, Engström-Ruud L, Bellman J, Palsdottir V, et al. (2019). "Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus". Neuroendocrinology. 109 (4): 310–321. doi:10.1159/000499693. PMID30889580. S2CID208014066.
Colbert LH, Davis JM, Essig DA, Ghaffar A, Mayer EP (May 2001). "Tissue expression and plasma concentrations of TNFalpha, IL-1beta, and IL-6 following treadmill exercise in mice". International Journal of Sports Medicine. 22 (4): 261–267. doi:10.1055/s-2001-13818. PMID11414667. S2CID260192304.
Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, et al. (August 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell. 58 (3): 573–581. doi:10.1016/0092-8674(89)90438-8. PMID2788034. S2CID41245022.
Kallen KJ, zum Büschenfelde KH, Rose-John S (March 1997). "The therapeutic potential of interleukin-6 hyperagonists and antagonists". Expert Opinion on Investigational Drugs. 6 (3): 237–266. doi:10.1517/13543784.6.3.237. PMID15989626.
Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. (March 2010). "A meta-analysis of cytokines in major depression". Biological Psychiatry. 67 (5): 446–457. doi:10.1016/j.biopsych.2009.09.033. PMID20015486. S2CID230209.
Swardfager W, Lanctôt K, Rothenburg L, Wong A, Cappell J, Herrmann N (November 2010). "A meta-analysis of cytokines in Alzheimer's disease". Biological Psychiatry. 68 (10): 930–941. doi:10.1016/j.biopsych.2010.06.012. PMID20692646. S2CID6544784.
Gadó K, Domján G, Hegyesi H, Falus A (2000). "Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma". Cell Biology International. 24 (4): 195–209. doi:10.1006/cbir.2000.0497. PMID10816321. S2CID44820455.
Smith PC, Hobisch A, Lin DL, Culig Z, Keller ET (March 2001). "Interleukin-6 and prostate cancer progression". Cytokine & Growth Factor Reviews. 12 (1): 33–40. doi:10.1016/S1359-6101(00)00021-6. PMID11312117.
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, et al. (July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage". Progress in Neurobiology. 178: 101610. doi:10.1016/j.pneurobio.2019.03.003. PMID30923023. S2CID85495400.
Barton BE (August 2005). "Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes". Expert Opinion on Therapeutic Targets. 9 (4): 737–752. doi:10.1517/14728222.9.4.737. PMID16083340. S2CID45421426.
Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, et al. (March 2008). "Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial". Lancet. 371 (9617): 998–1006. doi:10.1016/S0140-6736(08)60454-7. PMID18358927. S2CID21554759.
Remmler J, Schneider C, Treuner-Kaueroff T, Bartels M, Seehofer D, Scholz M, et al. (May 2018). "Increased Level of Interleukin 6 Associates With Increased 90-Day and 1-Year Mortality in Patients With End-Stage Liver Disease". Clinical Gastroenterology and Hepatology. 16 (5): 730–737. doi:10.1016/j.cgh.2017.09.017. PMID28919544. S2CID4408167.
Arroyo V, Angeli P, Moreau R, Jalan R, Clària J, Trebicka J, et al. (March 2021). "The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis". Journal of Hepatology. 74 (3): 670–685. doi:10.1016/j.jhep.2020.11.048. hdl:2445/175350. PMID33301825.
Guidotti A, Auta J, Davis JM, Di-Giorgi-Gerevini V, Dwivedi Y, Grayson DR, et al. (November 2000). "Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study". Archives of General Psychiatry. 57 (11): 1061–1069. doi:10.1001/archpsyc.57.11.1061. PMID11074872.
Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (December 2006). "The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression". Neurobiology of Aging. 27 (12): 1834–1837. doi:10.1016/j.neurobiolaging.2005.10.013. PMID16343697. S2CID23626890.
Somerville LH, Heatherton TF, Kelley WM (August 2006). "Anterior cingulate cortex responds differentially to expectancy violation and social rejection". Nature Neuroscience. 9 (8): 1007–1008. doi:10.1038/nn1728. PMID16819523. S2CID35224855.
Azzolina A, Bongiovanni A, Lampiasi N (December 2003). "Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1643 (1–3): 75–83. doi:10.1016/j.bbamcr.2003.09.003. PMID14654230.
Ratti E, Bettica P, Alexander R, Archer G, Carpenter D, Evoniuk G, et al. (May 2013). "Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies". Journal of Psychopharmacology. 27 (5): 424–434. doi:10.1177/0269881113480990. PMID23539641. S2CID6523822.
Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, et al. (September 1998). "Distinct mechanism for antidepressant activity by blockade of central substance P receptors". Science. 281 (5383): 1640–1645. Bibcode:1998Sci...281.1640K. doi:10.1126/science.281.5383.1640. PMID9733503.
Musselman DL, Miller AH, Porter MR, Manatunga A, Gao F, Penna S, et al. (August 2001). "Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings". The American Journal of Psychiatry. 158 (8): 1252–1257. doi:10.1176/appi.ajp.158.8.1252. PMID11481159.
Arroyo V, Angeli P, Moreau R, Jalan R, Clària J, Trebicka J, et al. (March 2021). "The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis". Journal of Hepatology. 74 (3): 670–685. doi:10.1016/j.jhep.2020.11.048. hdl:2445/175350. PMID33301825.
Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, et al. (September 1998). "Distinct mechanism for antidepressant activity by blockade of central substance P receptors". Science. 281 (5383): 1640–1645. Bibcode:1998Sci...281.1640K. doi:10.1126/science.281.5383.1640. PMID9733503.
Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB, Ruddle FH (April 1988). "Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21". Genomics. 2 (3): 203–208. doi:10.1016/0888-7543(88)90003-1. PMID3294161.
Banks WA, Kastin AJ, Gutierrez EG (September 1994). "Penetration of interleukin-6 across the murine blood–brain barrier". Neuroscience Letters. 179 (1–2): 53–56. doi:10.1016/0304-3940(94)90933-4. PMID7845624. S2CID22712577.
Wernstedt I, Edgley A, Berndtsson A, Fäldt J, Bergström G, Wallenius V, et al. (September 2006). "Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 291 (3): R551–R557. doi:10.1152/ajpregu.00514.2005. PMID16455769.
Fäldt J, Wernstedt I, Fitzgerald SM, Wallenius K, Bergström G, Jansson JO (June 2004). "Reduced exercise endurance in interleukin-6-deficient mice". Endocrinology. 145 (6): 2680–2686. doi:10.1210/en.2003-1319. PMID14988384.
Matthews VB, Allen TL, Risis S, Chan MH, Henstridge DC, Watson N, et al. (November 2010). "Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance". Diabetologia. 53 (11): 2431–2441. doi:10.1007/s00125-010-1865-y. PMID20697689. S2CID12970519.
Di Gregorio GB, Hensley L, Lu T, Ranganathan G, Kern PA (July 2004). "Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity". American Journal of Physiology. Endocrinology and Metabolism. 287 (1): E182–E187. doi:10.1152/ajpendo.00189.2003. PMID15191885.
Wallenius K, Wallenius V, Sunter D, Dickson SL, Jansson JO (April 2002). "Intracerebroventricular interleukin-6 treatment decreases body fat in rats". Biochemical and Biophysical Research Communications. 293 (1): 560–565. doi:10.1016/S0006-291X(02)00230-9. PMID12054638.
Anesten F, Mishra D, Dalmau Gasull A, Engström-Ruud L, Bellman J, Palsdottir V, et al. (2019). "Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus". Neuroendocrinology. 109 (4): 310–321. doi:10.1159/000499693. PMID30889580. S2CID208014066.
Colbert LH, Davis JM, Essig DA, Ghaffar A, Mayer EP (May 2001). "Tissue expression and plasma concentrations of TNFalpha, IL-1beta, and IL-6 following treadmill exercise in mice". International Journal of Sports Medicine. 22 (4): 261–267. doi:10.1055/s-2001-13818. PMID11414667. S2CID260192304.
Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, et al. (August 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell. 58 (3): 573–581. doi:10.1016/0092-8674(89)90438-8. PMID2788034. S2CID41245022.
Kallen KJ, zum Büschenfelde KH, Rose-John S (March 1997). "The therapeutic potential of interleukin-6 hyperagonists and antagonists". Expert Opinion on Investigational Drugs. 6 (3): 237–266. doi:10.1517/13543784.6.3.237. PMID15989626.
Dubiński A, Zdrojewicz Z (April 2007). "[The role of interleukin-6 in development and progression of atherosclerosis]". Polski Merkuriusz Lekarski (in Polish). 22 (130): 291–294. PMID17684929.
Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. (March 2010). "A meta-analysis of cytokines in major depression". Biological Psychiatry. 67 (5): 446–457. doi:10.1016/j.biopsych.2009.09.033. PMID20015486. S2CID230209.
Swardfager W, Lanctôt K, Rothenburg L, Wong A, Cappell J, Herrmann N (November 2010). "A meta-analysis of cytokines in Alzheimer's disease". Biological Psychiatry. 68 (10): 930–941. doi:10.1016/j.biopsych.2010.06.012. PMID20692646. S2CID6544784.
Gadó K, Domján G, Hegyesi H, Falus A (2000). "Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma". Cell Biology International. 24 (4): 195–209. doi:10.1006/cbir.2000.0497. PMID10816321. S2CID44820455.
Smith PC, Hobisch A, Lin DL, Culig Z, Keller ET (March 2001). "Interleukin-6 and prostate cancer progression". Cytokine & Growth Factor Reviews. 12 (1): 33–40. doi:10.1016/S1359-6101(00)00021-6. PMID11312117.
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, et al. (July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage". Progress in Neurobiology. 178: 101610. doi:10.1016/j.pneurobio.2019.03.003. PMID30923023. S2CID85495400.
Barton BE (August 2005). "Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes". Expert Opinion on Therapeutic Targets. 9 (4): 737–752. doi:10.1517/14728222.9.4.737. PMID16083340. S2CID45421426.
Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, et al. (March 2008). "Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial". Lancet. 371 (9617): 998–1006. doi:10.1016/S0140-6736(08)60454-7. PMID18358927. S2CID21554759.
Remmler J, Schneider C, Treuner-Kaueroff T, Bartels M, Seehofer D, Scholz M, et al. (May 2018). "Increased Level of Interleukin 6 Associates With Increased 90-Day and 1-Year Mortality in Patients With End-Stage Liver Disease". Clinical Gastroenterology and Hepatology. 16 (5): 730–737. doi:10.1016/j.cgh.2017.09.017. PMID28919544. S2CID4408167.
Arroyo V, Angeli P, Moreau R, Jalan R, Clària J, Trebicka J, et al. (March 2021). "The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis". Journal of Hepatology. 74 (3): 670–685. doi:10.1016/j.jhep.2020.11.048. hdl:2445/175350. PMID33301825.
Hodge DR, Cho E, Copeland TD, Guszczynski T, Yang E, Seth AK, et al. (2007). "IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase". Cancer Genomics & Proteomics. 4 (6): 387–398. PMID18204201.
Guidotti A, Auta J, Davis JM, Di-Giorgi-Gerevini V, Dwivedi Y, Grayson DR, et al. (November 2000). "Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study". Archives of General Psychiatry. 57 (11): 1061–1069. doi:10.1001/archpsyc.57.11.1061. PMID11074872.
Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (December 2006). "The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression". Neurobiology of Aging. 27 (12): 1834–1837. doi:10.1016/j.neurobiolaging.2005.10.013. PMID16343697. S2CID23626890.
Somerville LH, Heatherton TF, Kelley WM (August 2006). "Anterior cingulate cortex responds differentially to expectancy violation and social rejection". Nature Neuroscience. 9 (8): 1007–1008. doi:10.1038/nn1728. PMID16819523. S2CID35224855.
Azzolina A, Bongiovanni A, Lampiasi N (December 2003). "Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1643 (1–3): 75–83. doi:10.1016/j.bbamcr.2003.09.003. PMID14654230.
Ratti E, Bettica P, Alexander R, Archer G, Carpenter D, Evoniuk G, et al. (May 2013). "Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies". Journal of Psychopharmacology. 27 (5): 424–434. doi:10.1177/0269881113480990. PMID23539641. S2CID6523822.
Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, et al. (September 1998). "Distinct mechanism for antidepressant activity by blockade of central substance P receptors". Science. 281 (5383): 1640–1645. Bibcode:1998Sci...281.1640K. doi:10.1126/science.281.5383.1640. PMID9733503.
Musselman DL, Miller AH, Porter MR, Manatunga A, Gao F, Penna S, et al. (August 2001). "Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings". The American Journal of Psychiatry. 158 (8): 1252–1257. doi:10.1176/appi.ajp.158.8.1252. PMID11481159.
Anesten F, Mishra D, Dalmau Gasull A, Engström-Ruud L, Bellman J, Palsdottir V, et al. (2019). "Glucagon-Like Peptide-1-, but not Growth and Differentiation Factor 15-, Receptor Activation Increases the Number of Interleukin-6-Expressing Cells in the External Lateral Parabrachial Nucleus". Neuroendocrinology. 109 (4): 310–321. doi:10.1159/000499693. PMID30889580. S2CID208014066.
Colbert LH, Davis JM, Essig DA, Ghaffar A, Mayer EP (May 2001). "Tissue expression and plasma concentrations of TNFalpha, IL-1beta, and IL-6 following treadmill exercise in mice". International Journal of Sports Medicine. 22 (4): 261–267. doi:10.1055/s-2001-13818. PMID11414667. S2CID260192304.
Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, et al. (August 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell. 58 (3): 573–581. doi:10.1016/0092-8674(89)90438-8. PMID2788034. S2CID41245022.
Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. (March 2010). "A meta-analysis of cytokines in major depression". Biological Psychiatry. 67 (5): 446–457. doi:10.1016/j.biopsych.2009.09.033. PMID20015486. S2CID230209.
Swardfager W, Lanctôt K, Rothenburg L, Wong A, Cappell J, Herrmann N (November 2010). "A meta-analysis of cytokines in Alzheimer's disease". Biological Psychiatry. 68 (10): 930–941. doi:10.1016/j.biopsych.2010.06.012. PMID20692646. S2CID6544784.
Gadó K, Domján G, Hegyesi H, Falus A (2000). "Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma". Cell Biology International. 24 (4): 195–209. doi:10.1006/cbir.2000.0497. PMID10816321. S2CID44820455.
Zhu H, Wang Z, Yu J, Yang X, He F, Liu Z, et al. (July 2019). "Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage". Progress in Neurobiology. 178: 101610. doi:10.1016/j.pneurobio.2019.03.003. PMID30923023. S2CID85495400.
Barton BE (August 2005). "Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes". Expert Opinion on Therapeutic Targets. 9 (4): 737–752. doi:10.1517/14728222.9.4.737. PMID16083340. S2CID45421426.
Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, et al. (March 2008). "Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial". Lancet. 371 (9617): 998–1006. doi:10.1016/S0140-6736(08)60454-7. PMID18358927. S2CID21554759.
Remmler J, Schneider C, Treuner-Kaueroff T, Bartels M, Seehofer D, Scholz M, et al. (May 2018). "Increased Level of Interleukin 6 Associates With Increased 90-Day and 1-Year Mortality in Patients With End-Stage Liver Disease". Clinical Gastroenterology and Hepatology. 16 (5): 730–737. doi:10.1016/j.cgh.2017.09.017. PMID28919544. S2CID4408167.
Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (December 2006). "The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression". Neurobiology of Aging. 27 (12): 1834–1837. doi:10.1016/j.neurobiolaging.2005.10.013. PMID16343697. S2CID23626890.
Somerville LH, Heatherton TF, Kelley WM (August 2006). "Anterior cingulate cortex responds differentially to expectancy violation and social rejection". Nature Neuroscience. 9 (8): 1007–1008. doi:10.1038/nn1728. PMID16819523. S2CID35224855.
Ratti E, Bettica P, Alexander R, Archer G, Carpenter D, Evoniuk G, et al. (May 2013). "Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies". Journal of Psychopharmacology. 27 (5): 424–434. doi:10.1177/0269881113480990. PMID23539641. S2CID6523822.