Intron (English Wikipedia)

"The notion of the cistron [i.e., gene] ... must be replaced by that of a transcription unit containing regions which will be lost from the mature messenger – which I suggest we call introns (for intragenic regions) – alternating with regions which will be expressed – exons." (Gilbert 1978) Gilbert W (February 1978). "Why genes in pieces?". Nature. 271 (5645): 501. Bibcode:1978Natur.271..501G. doi:10.1038/271501a0. PMID 622185. S2CID 4216649.
Kinniburgh AJ, Mertz JE, Ross J (July 1978). "The precursor of mouse beta-globin messenger RNA contains two intervening RNA sequences". Cell. 14 (3): 681–693. doi:10.1016/0092-8674(78)90251-9. PMID 688388. S2CID 21897383.
Chow LT, Gelinas RE, Broker TR, Roberts RJ (September 1977). "An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA". Cell. 12 (1): 1–8. doi:10.1016/0092-8674(77)90180-5. PMID 902310. S2CID 2099968.
Belfort M, Pedersen-Lane J, West D, Ehrenman K, Maley G, Chu F, Maley F (June 1985). "Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level". Cell. 41 (2): 375–382. doi:10.1016/s0092-8674(85)80010-6. PMID 3986907. S2CID 27127017.
Taanman JW (February 1999). "The mitochondrial genome: structure, transcription, translation and replication". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1410 (2): 103–123. doi:10.1016/s0005-2728(98)00161-3. PMID 10076021. S2CID 19229072.
Greer CL, Peebles CL, Gegenheimer P, Abelson J (February 1983). "Mechanism of action of a yeast RNA ligase in tRNA splicing". Cell. 32 (2): 537–546. doi:10.1016/0092-8674(83)90473-7. PMID 6297798. S2CID 44978152.
Reinhold-Hurek B, Shub DA (May 1992). "Self-splicing introns in tRNA genes of widely divergent bacteria". Nature. 357 (6374): 173–176. Bibcode:1992Natur.357..173R. doi:10.1038/357173a0. PMID 1579169. S2CID 4370160.
Wan R, Bai R, Zhan X, Shi Y (2020). "How is precursor messenger RNA spliced by the spliceosome?". Annual Review of Biochemistry. 89: 333–358. doi:10.1146/annurev-biochem-013118-111024. PMID 31815536. S2CID 209167227.
Wilkinson ME, Charenton C, Nagai K (2020). "RNA splicing by the spliceosome". Annual Review of Biochemistry. 89: 359–388. doi:10.1146/annurev-biochem-091719-064225. PMID 31794245. S2CID 208626110.
Sales-Lee J, Perry DS, Bowser BA, Diedrich JK, Rao B, Beusch I, Yates III JR, Roy SW, Madhani HD (2021). "Coupling of spliceosome complexity to intron diversity". Current Biology. 31 (22): 4898–4910 e4894. Bibcode:2021CBio...31E4898S. doi:10.1016/j.cub.2021.09.004. PMC 8967684. PMID 34555349. S2CID 237603074.
Hsu SN, Hertel KJ (2009). "Spliceosomes walk the line: splicing errors and their impact on cellular function". RNA Biology. 6 (5): 526–530. doi:10.4161/rna.6.5.9860. PMC 3912188. PMID 19829058. S2CID 22592978.
Shirley B, Mucaki E, Rogan P (2019). "Pan-cancer repository of validated natural and cryptic mRNA splicing mutations". F1000Research. 7: 1908. doi:10.12688/f1000research.17204.3. PMC 6544075. PMID 31275557. S2CID 202702147.
Rogaev EI, Grigorenko AP, Faskhutdinova G, Kittler EL, Moliaka YK (2009). "Genotype analysis identifies the cause of the "royal disease"". Science. 326 (5954): 817. Bibcode:2009Sci...326..817R. doi:10.1126/science.1180660. PMID 19815722. S2CID 206522975.
Bicknell AA, Cenik C, Chua HN, Roth FP, Moore MJ (December 2012). "Introns in UTRs: why we should stop ignoring them". BioEssays. 34 (12): 1025–1034. doi:10.1002/bies.201200073. PMID 23108796. S2CID 5808466.
Penny D, Hoeppner MP, Poole AM, Jeffares DC (November 2009). "An overview of the introns-first theory". Journal of Molecular Evolution. 69 (5): 527–540. Bibcode:2009JMolE..69..527P. doi:10.1007/s00239-009-9279-5. PMID 19777149. S2CID 22386774.
Doolittle WF (1991). "The origins of introns". Current Biology. 1 (3): 145–146. Bibcode:1991CBio....1..145D. doi:10.1016/0960-9822(91)90214-h. PMID 15336149. S2CID 35790897.
Sharp PA (1991). ""Five easy pieces."(role of RNA catalysis in cellular processes)". Science. 254 (5032): 663–664. doi:10.1126/science.1948046. PMID 1948046. S2CID 508870.
Mourier T, Jeffares DC (May 2003). "Eukaryotic intron loss". Science. 300 (5624): 1393. doi:10.1126/science.1080559. PMID 12775832. S2CID 7235937.
Roy SW, Gilbert W (March 2006). "The evolution of spliceosomal introns: patterns, puzzles and progress". Nature Reviews. Genetics. 7 (3): 211–221. doi:10.1038/nrg1807. PMID 16485020. S2CID 33672491.
de Souza SJ (July 2003). "The emergence of a synthetic theory of intron evolution". Genetica. 118 (2–3): 117–121. doi:10.1023/A:1024193323397. PMID 12868602. S2CID 7539892.
Castillo-Davis CI, Mekhedov SL, Hartl DL, Koonin EV, Kondrashov FA (August 2002). "Selection for short introns in highly expressed genes". Nature Genetics. 31 (4): 415–418. doi:10.1038/ng940. PMID 12134150. S2CID 9057609.
Parenteau J, Maignon L, Berthoumieux M, Catala M, Gagnon V, Abou Elela S (January 2019). "Introns are mediators of cell response to starvation". Nature. 565 (7741): 612–617. Bibcode:2019Natur.565..612P. doi:10.1038/s41586-018-0859-7. PMID 30651641. S2CID 58014466.
Derr LK, Strathern JN (January 1993). "A role for reverse transcripts in gene conversion". Nature. 361 (6408): 170–173. Bibcode:1993Natur.361..170D. doi:10.1038/361170a0. PMID 8380627. S2CID 4364102.
Cech TR (January 1986). "The generality of self-splicing RNA: relationship to nuclear mRNA splicing". Cell. 44 (2): 207–210. doi:10.1016/0092-8674(86)90751-8. PMID 2417724. S2CID 11652546.

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Lewin B (1987). Genes (3rd ed.). New York: Wiley. pp. 159–179, 386. ISBN 0-471-83278-2. OCLC 14069165.

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Castillo-Davis CI, Mekhedov SL, Hartl DL, Koonin EV, Kondrashov FA (August 2002). "Selection for short introns in highly expressed genes". Nature Genetics. 31 (4): 415–418. doi:10.1038/ng940. PMID 12134150. S2CID 9057609.
Derr LK, Strathern JN (January 1993). "A role for reverse transcripts in gene conversion". Nature. 361 (6408): 170–173. Bibcode:1993Natur.361..170D. doi:10.1038/361170a0. PMID 8380627. S2CID 4364102.

Intron (English Wikipedia)

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