Ipilimumab (English Wikipedia)

"Yervoy (ipilimumab) [package insert]" (PDF). Princeton, NJ: Bristol-Myers Squibb Company; Dec 2013. Archived from the original (PDF) on 6 February 2015. Retrieved 29 October 2014.

books.google.com

Wilkes GM, Barton-Burke M (11 December 2009). 2010 oncology nursing drug handbook. Jones & Bartlett Learning. pp. 1–. ISBN 978-0-7637-8124-8. Retrieved 30 March 2011.
Reddy LH, Couvreur P (1 June 2009). Macromolecular Anticancer Therapeutics. Springer. pp. 522–. ISBN 978-1-4419-0506-2. Retrieved 30 March 2011.
An Z (8 September 2009). Therapeutic Monoclonal Antibodies: From Bench to Clinic. John Wiley and Sons. pp. 134–. ISBN 978-0-470-11791-0. Retrieved 30 March 2011.

clinicaltrials.gov

Clinical trial number NCT01524991 for "First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma" at ClinicalTrials.gov (completed)
Clinical trial number NCT00323882 for "Phase I/II Study of MDX-010 in Patients With Metastatic Hormone-Refractory Prostate Cancer (MDX010-21)" at ClinicalTrials.gov (completed)
"Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7 - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2016-02-27.
Clinical trial number NCT01984255 for "A Two-arm, Single Center Phase 1b Trial of Bavituximab Plus Ipilimumab in Advanced Melanoma Patients" at ClinicalTrials.gov

doi.org

Syn NL, Teng MW, Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731–e741. doi:10.1016/s1470-2045(17)30607-1. PMID 29208439.
Ribas A (June 2012). "Tumor immunotherapy directed at PD-1". The New England Journal of Medicine. 366 (26): 2517–2519. doi:10.1056/nejme1205943. PMID 22658126.
Leach DR, Krummel MF, Allison JP (March 1996). "Enhancement of antitumor immunity by CTLA-4 blockade". Science. 271 (5256): 1734–1736. Bibcode:1996Sci...271.1734L. doi:10.1126/science.271.5256.1734. PMID 8596936. S2CID 7215817.
Maverakis E, Cornelius LA, Bowen GM, Phan T, Patel FB, Fitzmaurice S, et al. (May 2015). "Metastatic melanoma - a review of current and future treatment options". Acta Dermato-Venereologica. 95 (5): 516–524. doi:10.2340/00015555-2035. PMID 25520039.
Johnson DB, Peng C, Sosman JA (March 2015). "Nivolumab in melanoma: latest evidence and clinical potential". Therapeutic Advances in Medical Oncology. 7 (2): 97–106. doi:10.1177/1758834014567469. PMC 4346215. PMID 25755682.
Bellaguarda E, Hanauer S (February 2020). "Checkpoint Inhibitor-Induced Colitis". The American Journal of Gastroenterology. 115 (2): 202–210. doi:10.14309/ajg.0000000000000497. PMID 31922959. S2CID 210150535.
Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J (April 2013). "Hepatotoxicity with combination of vemurafenib and ipilimumab". The New England Journal of Medicine. 368 (14): 1365–1366. doi:10.1056/NEJMc1302338. PMID 23550685.
Tarhini AA, Iqbal F (June 2010). "CTLA-4 blockade: therapeutic potential in cancer treatments". OncoTargets and Therapy. 3: 15–25. doi:10.2147/ott.s4833. PMC 2895779. PMID 20616954.
Robert C, Ghiringhelli F (August 2009). "What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma?". The Oncologist. 14 (8): 848–861. doi:10.1634/theoncologist.2009-0028. PMID 19648604.
Colmone AC (2014). "Cancer immunotherapy expands T cell attack". Science. 345 (6203): 1463. Bibcode:2014Sci...345Q1463C. doi:10.1126/science.345.6203.1463-c.
Gubin MM, Schreiber RD (October 2015). "CANCER. The odds of immunotherapy success". Science. 350 (6257): 158–159. Bibcode:2015Sci...350..158G. doi:10.1126/science.aad4140. PMID 26450194. S2CID 206643238.
Sharma P, Allison JP (April 2015). "The future of immune checkpoint therapy". Science. 348 (6230): 56–61. Bibcode:2015Sci...348...56S. doi:10.1126/science.aaa8172. PMID 25838373. S2CID 4608450.
Tomillero A, Moral MA (October 2008). "Gateways to clinical trials". Methods and Findings in Experimental and Clinical Pharmacology. 30 (8): 643–672. doi:10.1358/mf.2008.30.5.1236622. PMID 19088949.
Poust J (December 2008). "Targeting metastatic melanoma". American Journal of Health-System Pharmacy. 65 (24 Suppl 9): S9–S15. doi:10.2146/ajhp080461. PMID 19052265. S2CID 207291355.
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. (August 2010). "Improved survival with ipilimumab in patients with metastatic melanoma". The New England Journal of Medicine. 363 (8): 711–723. doi:10.1056/NEJMoa1003466. PMC 3549297. PMID 20525992.
Silberstein JL, Taylor MN, Antonarakis ES (April 2016). "Novel Insights into Molecular Indicators of Response and Resistance to Modern Androgen-Axis Therapies in Prostate Cancer". Current Urology Reports. 17 (4): 29. doi:10.1007/s11934-016-0584-4. PMC 4888068. PMID 26902623.
Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, et al. (September 2014). "AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer". The New England Journal of Medicine. 371 (11): 1028–1038. doi:10.1056/NEJMoa1315815. PMC 4201502. PMID 25184630.
Hellmann MD, Paz-Ares L, Bernabe Caro R, Zurawski B, Kim SW, Carcereny Costa E, et al. (November 2019). "Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer". The New England Journal of Medicine. 381 (21): 2020–2031. doi:10.1056/NEJMoa1910231. PMID 31562796.
Nasser NJ, Gorenberg M, Agbarya A (November 2020). "First line Immunotherapy for Non-Small Cell Lung Cancer". Pharmaceuticals. 13 (11): 373. doi:10.3390/ph13110373. PMC 7695295. PMID 33171686.
Reck M, Ciuleanu TE, Dols MC, Schenker M, Zurawski B, Menezes J, et al. (2020-05-20). "Nivolumab (NIVO) + ipilimumab (IPI) + 2 cycles of platinum-doublet chemotherapy (chemo) vs 4 cycles chemo as first-line (1L) treatment (tx) for stage IV/recurrent non-small cell lung cancer (NSCLC): CheckMate 9LA". Journal of Clinical Oncology. 38 (15_suppl): 9501. doi:10.1200/JCO.2020.38.15_suppl.9501. ISSN 0732-183X. S2CID 219780650.
Galsky MD, Wang H, Hahn NM, Twardowski P, Pal SK, Albany C, et al. (May 2018). "Phase 2 Trial of Gemcitabine, Cisplatin, plus Ipilimumab in Patients with Metastatic Urothelial Cancer and Impact of DNA Damage Response Gene Mutations on Outcomes". European Urology. 73 (5): 751–759. doi:10.1016/j.eururo.2017.12.001. PMID 29248319.
Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P (Jul 1987). "A new member of the immunoglobulin superfamily--CTLA-4". Nature. 328 (6127): 267–270. Bibcode:1987Natur.328..267B. doi:10.1038/328267a0. PMID 3496540. S2CID 4316396.
Harper K, Balzano C, Rouvier E, Mattéi MG, Luciani MF, Golstein P (August 1991). "CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location". Journal of Immunology. 147 (3): 1037–1044. doi:10.4049/jimmunol.147.3.1037. PMID 1713603. S2CID 25735978.
Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP (April 1992). "CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones". Nature. 356 (6370): 607–609. Bibcode:1992Natur.356..607H. doi:10.1038/356607a0. PMID 1313950. S2CID 4333730.
Krummel MF, Allison JP (August 1995). "CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation". The Journal of Experimental Medicine. 182 (2): 459–465. doi:10.1084/jem.182.2.459. PMC 2192127. PMID 7543139.
Krummel MF, Sullivan TJ, Allison JP (April 1996). "Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo". International Immunology. 8 (4): 519–523. doi:10.1093/intimm/8.4.519. PMID 8671638.
Walunas TL, Bakker CY, Bluestone JA (June 1996). "CTLA-4 ligation blocks CD28-dependent T cell activation". The Journal of Experimental Medicine. 183 (6): 2541–2550. doi:10.1084/jem.183.6.2541. PMC 2192609. PMID 8676075.
Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, et al. (August 1994). "CTLA-4 can function as a negative regulator of T cell activation". Immunity. 1 (5): 405–413. doi:10.1016/1074-7613(94)90071-x. PMID 7882171.
Kearney ER, Walunas TL, Karr RW, Morton PA, Loh DY, Bluestone JA, Jenkins MK (August 1995). "Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4". Journal of Immunology. 155 (3): 1032–1036. doi:10.4049/jimmunol.155.3.1032. PMID 7543510. S2CID 23874889.
Linsley PS, Greene JL, Tan P, Bradshaw J, Ledbetter JA, Anasetti C, Damle NK (December 1992). "Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes". The Journal of Experimental Medicine. 176 (6): 1595–1604. doi:10.1084/jem.176.6.1595. PMC 2119471. PMID 1334116.

drugs.com

Drugs.com: Yervoy

europa.eu

ema.europa.eu

"Yervoy EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 2 October 2020.
"Yervoy Annex I: Summary of Product Characteristics" (PDF). Archived from the original (PDF) on 20 December 2014. Retrieved 2 November 2014.

fda.gov

"FDA approves new treatment for a type of late-stage skin cancer" (Press release). U.S. Food and Drug Administration (FDA). 2011-03-25. Archived from the original on 2011-03-27. Retrieved 2011-03-25.
"FDA approves Yervoy to reduce the risk of melanoma returning after surgery" (Press release). U.S. Food and Drug Administration (FDA). 28 October 2015. Archived from the original on 2015-10-29. Retrieved 2019-04-08.
"FDA approves nivolumab plus ipilimumab combination for intermediate or poor-risk advanced renal cell carcinoma". U.S. Food and Drug Administration (FDA). 16 April 2018. Retrieved 2 October 2020. This article incorporates text from this source, which is in the public domain.
"FDA grants accelerated approval to ipilimumab for MSI-H or dMMR metastatic colorectal cancer". U.S. Food and Drug Administration (FDA). 10 July 2018. Retrieved 2 October 2020. This article incorporates text from this source, which is in the public domain.
"FDA grants accelerated approval to nivolumab and ipilimumab combination for hepatocellular carcinoma". U.S. Food and Drug Administration (FDA). 10 March 2020. Retrieved 2 October 2020. This article incorporates text from this source, which is in the public domain.
"FDA approves nivolumab plus ipilimumab for first-line mNSCLC (PD-L1 tumor expression ≥1%)". U.S. Food and Drug Administration (FDA). 15 May 2020. Retrieved 2 October 2020. This article incorporates text from this source, which is in the public domain.
"FDA approves nivolumab plus ipilimumab and chemotherapy for first-line treatment of metastatic NSCLC". U.S. Food and Drug Administration (FDA). 26 May 2020. Retrieved 2 October 2020. This article incorporates text from this source, which is in the public domain.
"FDA Approves Drug Combination for Treating Mesothelioma". U.S. Food and Drug Administration (FDA) (Press release). 2 October 2020. Retrieved 2 October 2020. This article incorporates text from this source, which is in the public domain.

accessdata.fda.gov

"Drug Approval Package: Yervoy (ipilimumab) Injection NDA #125377". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 2 October 2020.

gene.com

"Zelboraf (vemurafenib) [package insert]" (PDF). South San Francisco, CA: Genentech USA, Inc.; March 2013. Retrieved 29 October 2014.

genengnews.com

"FDA Rubber-Stamps Bristol-Myers Squibb's Melanoma mAb". Genetic Engineering & Biotechnology News. 2011-03-28. Archived from the original on 2011-04-01. Retrieved 2011-03-28.

harvard.edu

ui.adsabs.harvard.edu

Leach DR, Krummel MF, Allison JP (March 1996). "Enhancement of antitumor immunity by CTLA-4 blockade". Science. 271 (5256): 1734–1736. Bibcode:1996Sci...271.1734L. doi:10.1126/science.271.5256.1734. PMID 8596936. S2CID 7215817.
Colmone AC (2014). "Cancer immunotherapy expands T cell attack". Science. 345 (6203): 1463. Bibcode:2014Sci...345Q1463C. doi:10.1126/science.345.6203.1463-c.
Gubin MM, Schreiber RD (October 2015). "CANCER. The odds of immunotherapy success". Science. 350 (6257): 158–159. Bibcode:2015Sci...350..158G. doi:10.1126/science.aad4140. PMID 26450194. S2CID 206643238.
Sharma P, Allison JP (April 2015). "The future of immune checkpoint therapy". Science. 348 (6230): 56–61. Bibcode:2015Sci...348...56S. doi:10.1126/science.aaa8172. PMID 25838373. S2CID 4608450.
Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P (Jul 1987). "A new member of the immunoglobulin superfamily--CTLA-4". Nature. 328 (6127): 267–270. Bibcode:1987Natur.328..267B. doi:10.1038/328267a0. PMID 3496540. S2CID 4316396.
Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP (April 1992). "CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones". Nature. 356 (6370): 607–609. Bibcode:1992Natur.356..607H. doi:10.1038/356607a0. PMID 1313950. S2CID 4333730.

healthvalue.net

"CTLA-4 strategies: Abatacept / Belatacept". healthvalue.net. Archived from the original on 2008-12-05. Retrieved 2009-06-24.

hpfb-dgpsa.ca

dhpp.hpfb-dgpsa.ca

"Regulatory Decision Summary for Yervoy". Drug and Health Products Portal. 7 December 2023. Retrieved 2 April 2024.

ki.se

"The Nobel Prize in Physiology or Medicine 2018 to James P. Allison and Tasuku Honjo". Archived from the original on 2018-12-24. Retrieved 2018-10-01.

laskerfoundation.org

Lasker Foundation. "Deep brain stimulation for Parkinson's disease". The Lasker Foundation.

mayoclinic.org

"Mayo Researchers: Dramatic Outcomes in Prostate Cancer Study". Mayo Clinic. 2009-06-01. Archived from the original on 2009-06-23. Retrieved 2009-06-24.

medicines.org.uk

"Yervoy 5 mg/ml concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 3 August 2020. Retrieved 2 October 2020.

medscape.com

"Two Cases of Myasthenia Gravis Seen With Ipilimumab". 2014-04-29.

nih.gov

pubmed.ncbi.nlm.nih.gov

Syn NL, Teng MW, Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731–e741. doi:10.1016/s1470-2045(17)30607-1. PMID 29208439.
Ribas A (June 2012). "Tumor immunotherapy directed at PD-1". The New England Journal of Medicine. 366 (26): 2517–2519. doi:10.1056/nejme1205943. PMID 22658126.
Leach DR, Krummel MF, Allison JP (March 1996). "Enhancement of antitumor immunity by CTLA-4 blockade". Science. 271 (5256): 1734–1736. Bibcode:1996Sci...271.1734L. doi:10.1126/science.271.5256.1734. PMID 8596936. S2CID 7215817.
Maverakis E, Cornelius LA, Bowen GM, Phan T, Patel FB, Fitzmaurice S, et al. (May 2015). "Metastatic melanoma - a review of current and future treatment options". Acta Dermato-Venereologica. 95 (5): 516–524. doi:10.2340/00015555-2035. PMID 25520039.
Johnson DB, Peng C, Sosman JA (March 2015). "Nivolumab in melanoma: latest evidence and clinical potential". Therapeutic Advances in Medical Oncology. 7 (2): 97–106. doi:10.1177/1758834014567469. PMC 4346215. PMID 25755682.
Bellaguarda E, Hanauer S (February 2020). "Checkpoint Inhibitor-Induced Colitis". The American Journal of Gastroenterology. 115 (2): 202–210. doi:10.14309/ajg.0000000000000497. PMID 31922959. S2CID 210150535.
Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J (April 2013). "Hepatotoxicity with combination of vemurafenib and ipilimumab". The New England Journal of Medicine. 368 (14): 1365–1366. doi:10.1056/NEJMc1302338. PMID 23550685.
Tarhini AA, Iqbal F (June 2010). "CTLA-4 blockade: therapeutic potential in cancer treatments". OncoTargets and Therapy. 3: 15–25. doi:10.2147/ott.s4833. PMC 2895779. PMID 20616954.
Robert C, Ghiringhelli F (August 2009). "What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma?". The Oncologist. 14 (8): 848–861. doi:10.1634/theoncologist.2009-0028. PMID 19648604.
Gubin MM, Schreiber RD (October 2015). "CANCER. The odds of immunotherapy success". Science. 350 (6257): 158–159. Bibcode:2015Sci...350..158G. doi:10.1126/science.aad4140. PMID 26450194. S2CID 206643238.
Sharma P, Allison JP (April 2015). "The future of immune checkpoint therapy". Science. 348 (6230): 56–61. Bibcode:2015Sci...348...56S. doi:10.1126/science.aaa8172. PMID 25838373. S2CID 4608450.
Tomillero A, Moral MA (October 2008). "Gateways to clinical trials". Methods and Findings in Experimental and Clinical Pharmacology. 30 (8): 643–672. doi:10.1358/mf.2008.30.5.1236622. PMID 19088949.
Poust J (December 2008). "Targeting metastatic melanoma". American Journal of Health-System Pharmacy. 65 (24 Suppl 9): S9–S15. doi:10.2146/ajhp080461. PMID 19052265. S2CID 207291355.
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. (August 2010). "Improved survival with ipilimumab in patients with metastatic melanoma". The New England Journal of Medicine. 363 (8): 711–723. doi:10.1056/NEJMoa1003466. PMC 3549297. PMID 20525992.
Silberstein JL, Taylor MN, Antonarakis ES (April 2016). "Novel Insights into Molecular Indicators of Response and Resistance to Modern Androgen-Axis Therapies in Prostate Cancer". Current Urology Reports. 17 (4): 29. doi:10.1007/s11934-016-0584-4. PMC 4888068. PMID 26902623.
Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, et al. (September 2014). "AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer". The New England Journal of Medicine. 371 (11): 1028–1038. doi:10.1056/NEJMoa1315815. PMC 4201502. PMID 25184630.
Hellmann MD, Paz-Ares L, Bernabe Caro R, Zurawski B, Kim SW, Carcereny Costa E, et al. (November 2019). "Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer". The New England Journal of Medicine. 381 (21): 2020–2031. doi:10.1056/NEJMoa1910231. PMID 31562796.
Nasser NJ, Gorenberg M, Agbarya A (November 2020). "First line Immunotherapy for Non-Small Cell Lung Cancer". Pharmaceuticals. 13 (11): 373. doi:10.3390/ph13110373. PMC 7695295. PMID 33171686.
Galsky MD, Wang H, Hahn NM, Twardowski P, Pal SK, Albany C, et al. (May 2018). "Phase 2 Trial of Gemcitabine, Cisplatin, plus Ipilimumab in Patients with Metastatic Urothelial Cancer and Impact of DNA Damage Response Gene Mutations on Outcomes". European Urology. 73 (5): 751–759. doi:10.1016/j.eururo.2017.12.001. PMID 29248319.
Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P (Jul 1987). "A new member of the immunoglobulin superfamily--CTLA-4". Nature. 328 (6127): 267–270. Bibcode:1987Natur.328..267B. doi:10.1038/328267a0. PMID 3496540. S2CID 4316396.
Harper K, Balzano C, Rouvier E, Mattéi MG, Luciani MF, Golstein P (August 1991). "CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location". Journal of Immunology. 147 (3): 1037–1044. doi:10.4049/jimmunol.147.3.1037. PMID 1713603. S2CID 25735978.
Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP (April 1992). "CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones". Nature. 356 (6370): 607–609. Bibcode:1992Natur.356..607H. doi:10.1038/356607a0. PMID 1313950. S2CID 4333730.
Krummel MF, Allison JP (August 1995). "CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation". The Journal of Experimental Medicine. 182 (2): 459–465. doi:10.1084/jem.182.2.459. PMC 2192127. PMID 7543139.
Krummel MF, Sullivan TJ, Allison JP (April 1996). "Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo". International Immunology. 8 (4): 519–523. doi:10.1093/intimm/8.4.519. PMID 8671638.
Walunas TL, Bakker CY, Bluestone JA (June 1996). "CTLA-4 ligation blocks CD28-dependent T cell activation". The Journal of Experimental Medicine. 183 (6): 2541–2550. doi:10.1084/jem.183.6.2541. PMC 2192609. PMID 8676075.
Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, et al. (August 1994). "CTLA-4 can function as a negative regulator of T cell activation". Immunity. 1 (5): 405–413. doi:10.1016/1074-7613(94)90071-x. PMID 7882171.
Kearney ER, Walunas TL, Karr RW, Morton PA, Loh DY, Bluestone JA, Jenkins MK (August 1995). "Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4". Journal of Immunology. 155 (3): 1032–1036. doi:10.4049/jimmunol.155.3.1032. PMID 7543510. S2CID 23874889.
Linsley PS, Greene JL, Tan P, Bradshaw J, Ledbetter JA, Anasetti C, Damle NK (December 1992). "Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes". The Journal of Experimental Medicine. 176 (6): 1595–1604. doi:10.1084/jem.176.6.1595. PMC 2119471. PMID 1334116.

ncbi.nlm.nih.gov

Johnson DB, Peng C, Sosman JA (March 2015). "Nivolumab in melanoma: latest evidence and clinical potential". Therapeutic Advances in Medical Oncology. 7 (2): 97–106. doi:10.1177/1758834014567469. PMC 4346215. PMID 25755682.
Tarhini AA, Iqbal F (June 2010). "CTLA-4 blockade: therapeutic potential in cancer treatments". OncoTargets and Therapy. 3: 15–25. doi:10.2147/ott.s4833. PMC 2895779. PMID 20616954.
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. (August 2010). "Improved survival with ipilimumab in patients with metastatic melanoma". The New England Journal of Medicine. 363 (8): 711–723. doi:10.1056/NEJMoa1003466. PMC 3549297. PMID 20525992.
Silberstein JL, Taylor MN, Antonarakis ES (April 2016). "Novel Insights into Molecular Indicators of Response and Resistance to Modern Androgen-Axis Therapies in Prostate Cancer". Current Urology Reports. 17 (4): 29. doi:10.1007/s11934-016-0584-4. PMC 4888068. PMID 26902623.
Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, et al. (September 2014). "AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer". The New England Journal of Medicine. 371 (11): 1028–1038. doi:10.1056/NEJMoa1315815. PMC 4201502. PMID 25184630.
Nasser NJ, Gorenberg M, Agbarya A (November 2020). "First line Immunotherapy for Non-Small Cell Lung Cancer". Pharmaceuticals. 13 (11): 373. doi:10.3390/ph13110373. PMC 7695295. PMID 33171686.
pmhdev. "Immunotherapy drug combo could combat melanoma". PubMed Health.
Krummel MF, Allison JP (August 1995). "CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation". The Journal of Experimental Medicine. 182 (2): 459–465. doi:10.1084/jem.182.2.459. PMC 2192127. PMID 7543139.
Walunas TL, Bakker CY, Bluestone JA (June 1996). "CTLA-4 ligation blocks CD28-dependent T cell activation". The Journal of Experimental Medicine. 183 (6): 2541–2550. doi:10.1084/jem.183.6.2541. PMC 2192609. PMID 8676075.
Linsley PS, Greene JL, Tan P, Bradshaw J, Ledbetter JA, Anasetti C, Damle NK (December 1992). "Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes". The Journal of Experimental Medicine. 176 (6): 1595–1604. doi:10.1084/jem.176.6.1595. PMC 2119471. PMID 1334116.

dailymed.nlm.nih.gov

"Yervoy- ipilimumab injection". DailyMed. 13 August 2020. Retrieved 2 October 2020.

novapublishers.com

Lacroix M (2014). Targeted Therapies in Cancer. Hauppauge, NY: Nova Sciences Publishers. ISBN 978-1-63321-687-7. Archived from the original on 2015-06-26. Retrieved 2014-07-13.

nytimes.com

Pollack A (May 29, 2015). "New Class of Drugs Shows More Promise in Treating Cancer". New York Times. Retrieved May 30, 2015.
Pollack A (2011-03-25). "Approval for Drug That Treats Melanoma". The New York Times. Retrieved 2011-03-27.

opdivo.com

"Yervoy". Opdivo. Bristol Myers Squibb. Retrieved 7 February 2024.

peregrineinc.com

ir.peregrineinc.com

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