KRAS (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "KRAS" in English language version.

refsWebsite

Global rank English rank

71nih.gov

4^th place

48doi.org

2^nd place

14semanticscholar.org

11^th place

8^th place

9harvard.edu

18^th place

17^th place

8clinicaltrials.gov

5,225^th place

4,062^nd place

4web.archive.org

1^st place

3handle.net

102^nd place

76^th place

2ensembl.org

1,626^th place

1,007^th place

1curetoday.com

low place

1eurekalert.org

3,538^th place

3,083^rd place

1nae.edu

low place

7,932^nd place

1pancan.org

low place

1oncogenetics.org

low place

1sciencedaily.com

993^rd place

920^th place

1evaluate.com

low place

1fda.gov

447^th place

338^th place

1cancer.gov

1,684^th place

1,350^th place

1science.org

1,160^th place

737^th place

cancer.gov (Global: 1,684^th place; English: 1,350^th place)

NCI Staff (2021-06-25). "Sotorasib is First KRAS Inhibitor Approved by FDA - NCI". Cancer Currents. National Cancer Institute. Retrieved 2022-06-04.

clinicaltrials.gov (Global: 5,225^th place; English: 4,062^nd place)

Clinical trial number NCT05737706 for "Study of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation" at ClinicalTrials.gov
Clinical trial number NCT03101839 for "Phase I Dose-Escalation Study of AZD4785 in Patients With Advanced Solid Tumours" at ClinicalTrials.gov
Clinical trial number NCT03785249 for "MRTX849 in Patients With Cancer Having a KRAS G12C Mutation" at ClinicalTrials.gov
"Study Record | A Study of Multiple Therapies in Biomarker-Selected Patients With Resectable Stages IB-III Non-Small Cell Lung Cancer". clinicaltrials.gov. Retrieved 2023-08-26.
"Study Record | A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)". clinicaltrials.gov. Retrieved 2023-08-26.
"Study Record | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation". clinicaltrials.gov. Retrieved 2023-08-26.
"Study Record | A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC) (B-FAST)". clinicaltrials.gov. Retrieved 2023-08-26.
"A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients". clinicaltrials.gov. 28 January 2021. Retrieved 26 July 2021.

curetoday.com (Global: low place; English: low place)

van Epps HL (Winter 2008). "Bittersweet Gene". CURE (Cancer Updates, Research and Education). Archived from the original on 2009-02-07.

doi.org (Global: 2^nd place; English: 2^nd place)

Tsuchida N, Ryder T, Ohtsubo E (September 1982). "Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus". Science. 217 (4563): 937–939. Bibcode:1982Sci...217..937T. doi:10.1126/science.6287573. PMID 6287573.
Kranenburg O (November 2005). "The KRAS oncogene: past, present, and future". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1756 (2): 81–82. doi:10.1016/j.bbcan.2005.10.001. PMID 16269215.
Welman A, Burger MM, Hagmann J (September 2000). "Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation". Oncogene. 19 (40): 4582–4591. doi:10.1038/sj.onc.1203818. PMID 11030147. S2CID 20878317.
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, et al. (September 2009). "Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells". Science. 325 (5947). New York, N.Y.: 1555–1559. Bibcode:2009Sci...325.1555Y. doi:10.1126/science.1174229. PMC 2820374. PMID 19661383.
Chiosea SI, Sherer CK, Jelic T, Dacic S (December 2011). "KRAS mutant allele-specific imbalance in lung adenocarcinoma". Modern Pathology. 24 (12): 1571–1577. doi:10.1038/modpathol.2011.109. PMID 21743433.
Hartman DJ, Davison JM, Foxwell TJ, Nikiforova MN, Chiosea SI (October 2012). "Mutant allele-specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival". International Journal of Cancer. 131 (8): 1810–1817. doi:10.1002/ijc.27461. PMID 22290300. S2CID 27328214.
Krasinskas AM, Moser AJ, Saka B, Adsay NV, Chiosea SI (October 2013). "KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas". Modern Pathology. 26 (10): 1346–1354. doi:10.1038/modpathol.2013.71. PMC 4128625. PMID 23599154.
Schubbert S, Zenker M, Rowe SL, Böll S, Klein C, Bollag G, et al. (March 2006). "Germline KRAS mutations cause Noonan syndrome". Nature Genetics. 38 (3): 331–336. doi:10.1038/ng1748. PMID 16474405. S2CID 8193354.
Niihori T, Aoki Y, Narumi Y, Neri G, Cavé H, Verloes A, et al. (March 2006). "Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome". Nature Genetics. 38 (3): 294–296. doi:10.1038/ng1749. PMID 16474404. S2CID 28915489.
Burmer GC, Loeb LA (April 1989). "Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 86 (7): 2403–2407. Bibcode:1989PNAS...86.2403B. doi:10.1073/pnas.86.7.2403. PMC 286921. PMID 2648401.
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M (May 1988). "Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes". Cell. 53 (4): 549–554. doi:10.1016/0092-8674(88)90571-5. PMID 2453289. S2CID 22457575.
Tam IY, Chung LP, Suen WS, Wang E, Wong MC, Ho KK, et al. (March 2006). "Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features". Clinical Cancer Research. 12 (5): 1647–1653. doi:10.1158/1078-0432.CCR-05-1981. PMID 16533793. S2CID 14795296.
Vogelstein B, Kinzler KW (August 2004). "Cancer genes and the pathways they control". Nature Medicine. 10 (8): 789–799. doi:10.1038/nm1087. PMID 15286780. S2CID 205383514.
Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R, et al. (June 2012). "Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum". Gut. 61 (6): 847–854. doi:10.1136/gutjnl-2011-300865. PMC 3345105. PMID 22427238.
Rosty C, Young JP, Walsh MD, Clendenning M, Walters RJ, Pearson S, et al. (June 2013). "Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features". Modern Pathology. 26 (6): 825–834. doi:10.1038/modpathol.2012.240. PMID 23348904.
Lièvre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, et al. (April 2006). "KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer". Cancer Research. 66 (8): 3992–3995. doi:10.1158/0008-5472.CAN-06-0191. PMID 16618717.
Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, et al. (February 2009). "Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer". Journal of Clinical Oncology. 27 (5): 663–671. doi:10.1200/JCO.2008.20.8397. hdl:2434/652169. PMID 19114683.
Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. (April 2009). "Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer". The New England Journal of Medicine. 360 (14): 1408–1417. doi:10.1056/NEJMoa0805019. PMID 19339720.
Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, et al. (June 2012). "Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer". Nature. 486 (7404): 532–536. Bibcode:2012Natur.486..532M. doi:10.1038/nature11156. PMC 3927413. PMID 22722830.
Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, et al. (September 2013). "KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy". International Journal of Cancer. 133 (5): 1259–1265. doi:10.1002/ijc.28106. hdl:2318/132493. PMID 23404247. S2CID 1791682.
Sankaranarayanan P, Schomay TE, Aiello KA, Alter O (April 2015). "Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival". PLOS ONE. 10 (4) e0121396. Bibcode:2015PLoSO..1021396S. doi:10.1371/journal.pone.0121396. PMC 4398562. PMID 25875127. AAAS EurekAlert! Press Release and NAE Podcast Feature.
Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, et al. (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5) e98293. Bibcode:2014PLoSO...998293C. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
Suda K, Tomizawa K, Mitsudomi T (March 2010). "Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation". Cancer and Metastasis Reviews. 29 (1): 49–60. doi:10.1007/s10555-010-9209-4. PMID 20108024. S2CID 19626219.
Riely GJ, Marks J, Pao W (April 2009). "KRAS mutations in non-small cell lung cancer". Proceedings of the American Thoracic Society. 6 (2): 201–205. doi:10.1513/pats.200809-107LC. PMID 19349489.
Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, et al. (January 2005). "KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib". PLOS Medicine. 2 (1) e17. doi:10.1371/journal.pmed.0020017. PMC 545207. PMID 15696205.
Nagy Á, Pongor LS, Szabó A, Santarpia M, Győrffy B (February 2017). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. PMC 5299512. PMID 27859136.
Guo W, Wu S, Liu J, Fang B (September 2008). "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota". Cancer Research. 68 (18): 7403–7408. doi:10.1158/0008-5472.CAN-08-1449. PMC 2678915. PMID 18794128.
Leroux C, Konstantinidou G (February 2021). "Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology". Cancers. 13 (4): 799. doi:10.3390/cancers13040799. PMC 7918504. PMID 33672917.
Lee MS, Pant S (November 2023). "Targeted Therapies for Pancreatic Cancer". In Pant S (ed.). Pancreatic Cancer. Cham: Springer. pp. 67–95. doi:10.1007/978-3-031-38623-7_5. ISBN 978-3-031-38623-7.
Wei D, Wang L, Zuo X, Maitra A, Bresalier RS (February 2024). "A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer". Clinical Cancer Research. 30 (4): 655–662. doi:10.1158/1078-0432.CCR-23-2098. PMC 10922474. PMID 37831007. S2CID 263967602.
Bannoura SF, Khan HY, Azmi AS (2022). "KRAS G12D targeted therapies for pancreatic cancer: Has the fortress been conquered?". Frontiers in Oncology. 12 1013902. doi:10.3389/fonc.2022.1013902. PMC 9749787. PMID 36531078.
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ (November 2014). "Drugging the undruggable RAS: Mission possible?". Nature Reviews. Drug Discovery. 13 (11): 828–851. doi:10.1038/nrd4389. PMC 4355017. PMID 25323927.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (November 2013). "K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions". Nature. 503 (7477): 548–551. Bibcode:2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.
Ostrem JM, Shokat KM (November 2016). "Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design". Nature Reviews. Drug Discovery. 15 (11): 771–785. doi:10.1038/nrd.2016.139. PMID 27469033.
Orgován Z, Keserű GM (December 2020). "Small molecule inhibitors of RAS proteins with oncogenic mutations". Cancer Metastasis Reviews. 39 (4): 1107–1126. doi:10.1007/s10555-020-09911-9. PMC 7680341. PMID 32770300.
Sabt A, Tawfik HO, Khaleel EF, Badi RM, Ibrahim HA, Elkaeed EB, et al. (December 2024). "An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review". Molecular Diversity. 28 (6): 4581–4608. doi:10.1007/s11030-023-10777-6. PMID 38289431.
Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, et al. (November 2019). "The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity". Nature. 575 (7781): 217–223. Bibcode:2019Natur.575..217C. doi:10.1038/s41586-019-1694-1. PMID 31666701. S2CID 204969251.
Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, et al. (January 2020). "Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors". Journal of Medicinal Chemistry. 63 (1): 52–65. doi:10.1021/acs.jmedchem.9b01180. PMID 31820981. S2CID 209313106.
McCormick F (January 2019). "Progress in targeting RAS with small molecule drugs". The Biochemical Journal. 476 (2): 365–374. doi:10.1042/BCJ20170441. PMID 30705085. S2CID 73414179.
Mullard A (July 2019). "KRAS's undruggability cracks?". Nature Reviews. Drug Discovery. 18 (7): 488. doi:10.1038/d41573-019-00102-y. PMID 31267080.
Sacher A, LoRusso P, Patel MR, Miller WH, Garralda E, Forster MD, et al. (August 2023). "Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation". The New England Journal of Medicine. 389 (8): 710–721. doi:10.1056/NEJMoa2303810. hdl:2268/311523. PMID 37611121. S2CID 261098837.
Leidner R, Sanjuan Silva N, Huang H, Sprott D, Zheng C, Shih YP, et al. (June 2022). "Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer". The New England Journal of Medicine. 386 (22): 2112–2119. doi:10.1056/NEJMoa2119662. PMC 9531755. PMID 35648703.
Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes & Development. 14 (8): 895–900. doi:10.1101/gad.14.8.895. PMC 316541. PMID 10783161.
Kiyono M, Kato J, Kataoka T, Kaziro Y, Satoh T (September 2000). "Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1". The Journal of Biological Chemistry. 275 (38): 29788–29793. doi:10.1074/jbc.M001378200. PMID 10882715.
Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, et al. (November 1999). "Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma". European Journal of Biochemistry. 266 (1): 70–82. doi:10.1046/j.1432-1327.1999.00815.x. PMID 10542052.
Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 12609–12613. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
Vos MD, Ellis CA, Elam C, Ulku AS, Taylor BJ, Clark GJ (July 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". The Journal of Biological Chemistry. 278 (30): 28045–28051. doi:10.1074/jbc.M300554200. PMID 12732644.
Villalonga P, López-Alcalá C, Bosch M, Chiloeches A, Rocamora N, Gil J, et al. (November 2001). "Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling". Molecular and Cellular Biology. 21 (21): 7345–7354. doi:10.1128/MCB.21.21.7345-7354.2001. PMC 99908. PMID 11585916.

ensembl.org (Global: 1,626^th place; English: 1,007^th place)

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000133703 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030265 – Ensembl, May 2017

eurekalert.org (Global: 3,538^th place; English: 3,083^rd place)

Sankaranarayanan P, Schomay TE, Aiello KA, Alter O (April 2015). "Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival". PLOS ONE. 10 (4) e0121396. Bibcode:2015PLoSO..1021396S. doi:10.1371/journal.pone.0121396. PMC 4398562. PMID 25875127. AAAS EurekAlert! Press Release and NAE Podcast Feature.

evaluate.com (Global: low place; English: low place)

Plieth J (26 April 2019). "Astra's first attempt fails, but there's no giving up on KRAS". Evaluate.

fda.gov (Global: 447^th place; English: 338^th place)

"FDA Approves First Targeted Therapy for Lung Cancer Mutation Previously Considered Resistant to Drug Therapy". U.S. Food and Drug Administration (FDA). 28 May 2021. Archived from the original on May 28, 2021. Retrieved 28 May 2021.

handle.net (Global: 102^nd place; English: 76^th place)

hdl.handle.net

Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, et al. (February 2009). "Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer". Journal of Clinical Oncology. 27 (5): 663–671. doi:10.1200/JCO.2008.20.8397. hdl:2434/652169. PMID 19114683.
Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, et al. (September 2013). "KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy". International Journal of Cancer. 133 (5): 1259–1265. doi:10.1002/ijc.28106. hdl:2318/132493. PMID 23404247. S2CID 1791682.
Sacher A, LoRusso P, Patel MR, Miller WH, Garralda E, Forster MD, et al. (August 2023). "Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation". The New England Journal of Medicine. 389 (8): 710–721. doi:10.1056/NEJMoa2303810. hdl:2268/311523. PMID 37611121. S2CID 261098837.

harvard.edu (Global: 18^th place; English: 17^th place)

ui.adsabs.harvard.edu

Tsuchida N, Ryder T, Ohtsubo E (September 1982). "Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus". Science. 217 (4563): 937–939. Bibcode:1982Sci...217..937T. doi:10.1126/science.6287573. PMID 6287573.
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, et al. (September 2009). "Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells". Science. 325 (5947). New York, N.Y.: 1555–1559. Bibcode:2009Sci...325.1555Y. doi:10.1126/science.1174229. PMC 2820374. PMID 19661383.
Burmer GC, Loeb LA (April 1989). "Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 86 (7): 2403–2407. Bibcode:1989PNAS...86.2403B. doi:10.1073/pnas.86.7.2403. PMC 286921. PMID 2648401.
Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, et al. (June 2012). "Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer". Nature. 486 (7404): 532–536. Bibcode:2012Natur.486..532M. doi:10.1038/nature11156. PMC 3927413. PMID 22722830.
Sankaranarayanan P, Schomay TE, Aiello KA, Alter O (April 2015). "Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival". PLOS ONE. 10 (4) e0121396. Bibcode:2015PLoSO..1021396S. doi:10.1371/journal.pone.0121396. PMC 4398562. PMID 25875127. AAAS EurekAlert! Press Release and NAE Podcast Feature.
Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, et al. (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5) e98293. Bibcode:2014PLoSO...998293C. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (November 2013). "K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions". Nature. 503 (7477): 548–551. Bibcode:2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.
Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, et al. (November 2019). "The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity". Nature. 575 (7781): 217–223. Bibcode:2019Natur.575..217C. doi:10.1038/s41586-019-1694-1. PMID 31666701. S2CID 204969251.
Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 12609–12613. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.

nae.edu (Global: low place; English: 7,932^nd place)

Sankaranarayanan P, Schomay TE, Aiello KA, Alter O (April 2015). "Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival". PLOS ONE. 10 (4) e0121396. Bibcode:2015PLoSO..1021396S. doi:10.1371/journal.pone.0121396. PMC 4398562. PMID 25875127. AAAS EurekAlert! Press Release and NAE Podcast Feature.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Tsuchida N, Ryder T, Ohtsubo E (September 1982). "Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus". Science. 217 (4563): 937–939. Bibcode:1982Sci...217..937T. doi:10.1126/science.6287573. PMID 6287573.
Markov K (1979). "Current state of our knowledge about prostaglandins". Patologicheskaia Fiziologiia I Eksperimental'naia Terapiia (5): 3–15. PMID 228228.
Kranenburg O (November 2005). "The KRAS oncogene: past, present, and future". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1756 (2): 81–82. doi:10.1016/j.bbcan.2005.10.001. PMID 16269215.
Welman A, Burger MM, Hagmann J (September 2000). "Structure and function of the C-terminal hypervariable region of K-Ras4B in plasma membrane targetting and transformation". Oncogene. 19 (40): 4582–4591. doi:10.1038/sj.onc.1203818. PMID 11030147. S2CID 20878317.
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, et al. (September 2009). "Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells". Science. 325 (5947). New York, N.Y.: 1555–1559. Bibcode:2009Sci...325.1555Y. doi:10.1126/science.1174229. PMC 2820374. PMID 19661383.
Chiosea SI, Sherer CK, Jelic T, Dacic S (December 2011). "KRAS mutant allele-specific imbalance in lung adenocarcinoma". Modern Pathology. 24 (12): 1571–1577. doi:10.1038/modpathol.2011.109. PMID 21743433.
Hartman DJ, Davison JM, Foxwell TJ, Nikiforova MN, Chiosea SI (October 2012). "Mutant allele-specific imbalance modulates prognostic impact of KRAS mutations in colorectal adenocarcinoma and is associated with worse overall survival". International Journal of Cancer. 131 (8): 1810–1817. doi:10.1002/ijc.27461. PMID 22290300. S2CID 27328214.
Krasinskas AM, Moser AJ, Saka B, Adsay NV, Chiosea SI (October 2013). "KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas". Modern Pathology. 26 (10): 1346–1354. doi:10.1038/modpathol.2013.71. PMC 4128625. PMID 23599154.
Schubbert S, Zenker M, Rowe SL, Böll S, Klein C, Bollag G, et al. (March 2006). "Germline KRAS mutations cause Noonan syndrome". Nature Genetics. 38 (3): 331–336. doi:10.1038/ng1748. PMID 16474405. S2CID 8193354.
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Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, et al. (June 2012). "Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer". Nature. 486 (7404): 532–536. Bibcode:2012Natur.486..532M. doi:10.1038/nature11156. PMC 3927413. PMID 22722830.
Sankaranarayanan P, Schomay TE, Aiello KA, Alter O (April 2015). "Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival". PLOS ONE. 10 (4) e0121396. Bibcode:2015PLoSO..1021396S. doi:10.1371/journal.pone.0121396. PMC 4398562. PMID 25875127. AAAS EurekAlert! Press Release and NAE Podcast Feature.
Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, et al. (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5) e98293. Bibcode:2014PLoSO...998293C. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, et al. (January 2005). "KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib". PLOS Medicine. 2 (1) e17. doi:10.1371/journal.pmed.0020017. PMC 545207. PMID 15696205.
Nagy Á, Pongor LS, Szabó A, Santarpia M, Győrffy B (February 2017). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. PMC 5299512. PMID 27859136.
Guo W, Wu S, Liu J, Fang B (September 2008). "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota". Cancer Research. 68 (18): 7403–7408. doi:10.1158/0008-5472.CAN-08-1449. PMC 2678915. PMID 18794128.
Leroux C, Konstantinidou G (February 2021). "Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology". Cancers. 13 (4): 799. doi:10.3390/cancers13040799. PMC 7918504. PMID 33672917.
Wei D, Wang L, Zuo X, Maitra A, Bresalier RS (February 2024). "A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer". Clinical Cancer Research. 30 (4): 655–662. doi:10.1158/1078-0432.CCR-23-2098. PMC 10922474. PMID 37831007. S2CID 263967602.
Bannoura SF, Khan HY, Azmi AS (2022). "KRAS G12D targeted therapies for pancreatic cancer: Has the fortress been conquered?". Frontiers in Oncology. 12 1013902. doi:10.3389/fonc.2022.1013902. PMC 9749787. PMID 36531078.
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ (November 2014). "Drugging the undruggable RAS: Mission possible?". Nature Reviews. Drug Discovery. 13 (11): 828–851. doi:10.1038/nrd4389. PMC 4355017. PMID 25323927.
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM (November 2013). "K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions". Nature. 503 (7477): 548–551. Bibcode:2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.
Orgován Z, Keserű GM (December 2020). "Small molecule inhibitors of RAS proteins with oncogenic mutations". Cancer Metastasis Reviews. 39 (4): 1107–1126. doi:10.1007/s10555-020-09911-9. PMC 7680341. PMID 32770300.
Leidner R, Sanjuan Silva N, Huang H, Sprott D, Zheng C, Shih YP, et al. (June 2022). "Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer". The New England Journal of Medicine. 386 (22): 2112–2119. doi:10.1056/NEJMoa2119662. PMC 9531755. PMID 35648703.
Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes & Development. 14 (8): 895–900. doi:10.1101/gad.14.8.895. PMC 316541. PMID 10783161.
Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 12609–12613. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
Villalonga P, López-Alcalá C, Bosch M, Chiloeches A, Rocamora N, Gil J, et al. (November 2001). "Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling". Molecular and Cellular Biology. 21 (21): 7345–7354. doi:10.1128/MCB.21.21.7345-7354.2001. PMC 99908. PMID 11585916.

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Niihori T, Aoki Y, Narumi Y, Neri G, Cavé H, Verloes A, et al. (March 2006). "Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome". Nature Genetics. 38 (3): 294–296. doi:10.1038/ng1749. PMID 16474404. S2CID 28915489.
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M (May 1988). "Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes". Cell. 53 (4): 549–554. doi:10.1016/0092-8674(88)90571-5. PMID 2453289. S2CID 22457575.
Tam IY, Chung LP, Suen WS, Wang E, Wong MC, Ho KK, et al. (March 2006). "Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features". Clinical Cancer Research. 12 (5): 1647–1653. doi:10.1158/1078-0432.CCR-05-1981. PMID 16533793. S2CID 14795296.
Vogelstein B, Kinzler KW (August 2004). "Cancer genes and the pathways they control". Nature Medicine. 10 (8): 789–799. doi:10.1038/nm1087. PMID 15286780. S2CID 205383514.
Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, et al. (September 2013). "KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy". International Journal of Cancer. 133 (5): 1259–1265. doi:10.1002/ijc.28106. hdl:2318/132493. PMID 23404247. S2CID 1791682.
Suda K, Tomizawa K, Mitsudomi T (March 2010). "Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation". Cancer and Metastasis Reviews. 29 (1): 49–60. doi:10.1007/s10555-010-9209-4. PMID 20108024. S2CID 19626219.
Wei D, Wang L, Zuo X, Maitra A, Bresalier RS (February 2024). "A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer". Clinical Cancer Research. 30 (4): 655–662. doi:10.1158/1078-0432.CCR-23-2098. PMC 10922474. PMID 37831007. S2CID 263967602.
Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, et al. (November 2019). "The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity". Nature. 575 (7781): 217–223. Bibcode:2019Natur.575..217C. doi:10.1038/s41586-019-1694-1. PMID 31666701. S2CID 204969251.
Lanman BA, Allen JR, Allen JG, Amegadzie AK, Ashton KS, Booker SK, et al. (January 2020). "Discovery of a Covalent Inhibitor of KRAS^G12C (AMG 510) for the Treatment of Solid Tumors". Journal of Medicinal Chemistry. 63 (1): 52–65. doi:10.1021/acs.jmedchem.9b01180. PMID 31820981. S2CID 209313106.
McCormick F (January 2019). "Progress in targeting RAS with small molecule drugs". The Biochemical Journal. 476 (2): 365–374. doi:10.1042/BCJ20170441. PMID 30705085. S2CID 73414179.
Sacher A, LoRusso P, Patel MR, Miller WH, Garralda E, Forster MD, et al. (August 2023). "Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation". The New England Journal of Medicine. 389 (8): 710–721. doi:10.1056/NEJMoa2303810. hdl:2268/311523. PMID 37611121. S2CID 261098837.

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KRAS (English Wikipedia)

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clinicaltrials.gov (Global: 5,225^th place; English: 4,062^nd place)

doi.org (Global: 2^nd place; English: 2^nd place)

ensembl.org (Global: 1,626^th place; English: 1,007^th place)

eurekalert.org (Global: 3,538^th place; English: 3,083^rd place)

fda.gov (Global: 447^th place; English: 338^th place)

handle.net (Global: 102^nd place; English: 76^th place)

harvard.edu (Global: 18^th place; English: 17^th place)

nae.edu (Global: low place; English: 7,932^nd place)

nih.gov (Global: 4^th place; English: 4^th place)

science.org (Global: 1,160^th place; English: 737^th place)

sciencedaily.com (Global: 993^rd place; English: 920^th place)

semanticscholar.org (Global: 11^th place; English: 8^th place)

web.archive.org (Global: 1^st place; English: 1^st place)