Analysis of information sources in references of the Wikipedia article "LPD-824" in English language version.
Cerletti: LPD-824 is chemically related to LSD. It is the pyrrolidid of lysergic acid, having the diethylamino group closed to a pyrrolidine nucleus (Figure 7). When this substance was tested in man, doses up to 1/2 μg./kg, were given intravenously without producing any LSD-like symptoms. Pharmacologically LPD is a very strong hypotensive agent. In animals 10 μg./kg. produces hypotension, both in cats and in dogs. As already said, in human subjects it had no psychic effect, but produced nausea in such small doses that a hypotensive effect could not be achieved.
TABLE 1 5-HT2A Receptor Affinity and Functional Effects of Selected Lysergamides1 [...] 1 Data from Parrish.42. [...] 42. Parrish JC. Toward a molecular understanding of hallucinogen action. 2006. Purdue University.
Lysergic acid pyrrolidide (LPD 824, No. 73 f) exhibits a modest LSD-like psychic effect (MURPHREE et a!., 1958), which ABRAMSON (1959) quantifies at 5% and ISBELL et a!. (1959 a) at 10% of the LSD-activity. As a serotonin-inhibitor, it shows 5% of the LSD-potency (CERLETTI and DOEPFNER, 1958a). Its dual action on the body temperature of the rat is identical to that of LSD (CERLETTI, 1956); as a pyretogenic in the rabbit, it exhibits 10% of the LSD potency (Sandoz Res. Lab., 1958).
Table 1 5-HT2A 5-HT2C, and 5-HT1A receptor affinity and functional effects for selected lysergamides [...] Pyrrolidide
The pyrrolidyl amide (4) was also included in the behavioral pharmacology part of this study, [...] Table I. Potency of Lysergic Acid Amides in 1-Trained Rats [...]
Cerletti: LPD-824 is chemically related to LSD. It is the pyrrolidid of lysergic acid, having the diethylamino group closed to a pyrrolidine nucleus (Figure 7). When this substance was tested in man, doses up to 1/2 μg./kg, were given intravenously without producing any LSD-like symptoms. Pharmacologically LPD is a very strong hypotensive agent. In animals 10 μg./kg. produces hypotension, both in cats and in dogs. As already said, in human subjects it had no psychic effect, but produced nausea in such small doses that a hypotensive effect could not be achieved.
Figure A.1 The series of amide substituted LSD derivatives used in this study. [...] LA-Pyr [...] Table A.1 Results of competition binding experiments and IP accumulation assays for the series of ergolines illustrated in Figure A.1. [...] LA-Pyr [...]
Table 1 5-HT2A 5-HT2C, and 5-HT1A receptor affinity and functional effects for selected lysergamides [...] Pyrrolidide
The results of the drug discrimination testing are given in Table 3. The experimental data can be found in Table 15 in appendix B. The four isomers of 17, and the pyrrolidide 5, completely substituted for LSD. [...] Table 3. Potency of lysergic acid amides in LSD-trained rats. [...]
Table 1 5-HT2A 5-HT2C, and 5-HT1A receptor affinity and functional effects for selected lysergamides [...] Pyrrolidide
The pyrrolidyl amide (4) was also included in the behavioral pharmacology part of this study, [...] Table I. Potency of Lysergic Acid Amides in 1-Trained Rats [...]
Lysergic acid pyrrolidide (LPD 824, No. 73 f) exhibits a modest LSD-like psychic effect (MURPHREE et a!., 1958), which ABRAMSON (1959) quantifies at 5% and ISBELL et a!. (1959 a) at 10% of the LSD-activity. As a serotonin-inhibitor, it shows 5% of the LSD-potency (CERLETTI and DOEPFNER, 1958a). Its dual action on the body temperature of the rat is identical to that of LSD (CERLETTI, 1956); as a pyretogenic in the rabbit, it exhibits 10% of the LSD potency (Sandoz Res. Lab., 1958).
TABLE 1 5-HT2A Receptor Affinity and Functional Effects of Selected Lysergamides1 [...] 1 Data from Parrish.42. [...] 42. Parrish JC. Toward a molecular understanding of hallucinogen action. 2006. Purdue University.
