Analysis of information sources in references of the Wikipedia article "MEAI" in English language version.
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5-Methoxy-2-aminoindane (MEAI or Chaperon) is a psychoactive compound of the aminoindane class with a mechanism of action described by one patent as being possibly mediated by binding to the dopamine D3 receptor (Haadsma-Svensson et al., 1994). In recent years MEAI has been recreationally used by many people, mainly in the UK, who report a mild euphoric, alcohol-like tipsy experience (Nutt, 2013; Slezak, 2014). Typically recreational users ingest orally MEAI at doses of up to 1–2 mg/kg body weight in a session and report an onset of effect of up to 4 h with reduced desire to consume alcoholic beverages.
5-Methoxy-2-aminoindane (MEAI or Chaperon) is a psychoactive compound of the aminoindane class with a mechanism of action described by one patent as being possibly mediated by binding to the dopamine D3 receptor (Haadsma-Svensson et al., 1994). In recent years MEAI has been recreationally used by many people, mainly in the UK, who report a mild euphoric, alcohol-like tipsy experience (Nutt, 2013; Slezak, 2014). Typically recreational users ingest orally MEAI at doses of up to 1–2 mg/kg body weight in a session and report an onset of effect of up to 4 h with reduced desire to consume alcoholic beverages.
5-Methoxy-2-aminoindane (MEAI or Chaperon) is a psychoactive compound of the aminoindane class with a mechanism of action described by one patent as being possibly mediated by binding to the dopamine D3 receptor (Haadsma-Svensson et al., 1994). In recent years MEAI has been recreationally used by many people, mainly in the UK, who report a mild euphoric, alcohol-like tipsy experience (Nutt, 2013; Slezak, 2014). Typically recreational users ingest orally MEAI at doses of up to 1–2 mg/kg body weight in a session and report an onset of effect of up to 4 h with reduced desire to consume alcoholic beverages.
RESULTS. Methamphetamine and amphetamine potently released NE (IC50s = 14.3 and 7.0 nM) and DA (IC50s = 40.4 nM and 24.8 nM), and were much less potent releasers of 5-HT (IC50s = 740 nM and 1765 nM). [...]
RESULTS. Methamphetamine and amphetamine potently released NE (IC50s = 14.3 and 7.0 nM) and DA (IC50s = 40.4 nM and 24.8 nM), and were much less potent releasers of 5-HT (IC50s = 740 nM and 1765 nM). [...]
5-Methoxy-2-aminoindane (MEAI or Chaperon) is a psychoactive compound of the aminoindane class with a mechanism of action described by one patent as being possibly mediated by binding to the dopamine D3 receptor (Haadsma-Svensson et al., 1994). In recent years MEAI has been recreationally used by many people, mainly in the UK, who report a mild euphoric, alcohol-like tipsy experience (Nutt, 2013; Slezak, 2014). Typically recreational users ingest orally MEAI at doses of up to 1–2 mg/kg body weight in a session and report an onset of effect of up to 4 h with reduced desire to consume alcoholic beverages.
RESULTS. Methamphetamine and amphetamine potently released NE (IC50s = 14.3 and 7.0 nM) and DA (IC50s = 40.4 nM and 24.8 nM), and were much less potent releasers of 5-HT (IC50s = 740 nM and 1765 nM). [...]
