MPTP (English Wikipedia)

Buchi, I. J. (1952). "Synthese und analgetische Wirkung einiger 1-Methyl-4-phenyl-piperidin-(4)-alkylsulfone. 1. Mitteilung". Helvetica Chimica Acta. 35 (5): 1527–1536. doi:10.1002/hlca.19520350514.
Duty, Susan; Jenner, Peter (2011). "Animal models of Parkinson's disease: A source of novel treatments and clues to the cause of the disease". British Journal of Pharmacology. 164 (4): 1357–1391. doi:10.1111/j.1476-5381.2011.01426.x. PMC 3229766. PMID 21486284.
Narmashiri, Abdolvahed; Abbaszadeh, Mojtaba; Ghazizadeh, Ali (2022). "The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis". Neuroscience & Biobehavioral Reviews. 140 104792. doi:10.1016/j.neubiorev.2022.104792. PMID 35872230. S2CID 250929452.
Frim, D. M.; Uhler, T. A.; Galpern, W. R.; Beal, M. F.; Breakefield, X. O.; Isacson, O. (1994). "Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat". Proceedings of the National Academy of Sciences. 91 (11): 5104–5108. Bibcode:1994PNAS...91.5104F. doi:10.1073/pnas.91.11.5104. PMC 43940. PMID 8197193.
Richardson, Jason (2005). "Richardson, Jason R., et al. "Paraquat neurotoxicity is distinct from that of MPTP and rotenone". Toxicological Sciences. 88 (1): 193–201. doi:10.1093/toxsci/kfi304. PMID 16141438.
Fahn, S. (1996). "Book Review -- The Case of the Frozen Addicts: How the Solution of an Extraordinary Medical Mystery Spawned a Revolution in the Understanding and Treatment of Parkinson's Disease". The New England Journal of Medicine. 335 (26): 2002–2003. doi:10.1056/NEJM199612263352618.
Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ (1979). "Chronic parkinsonism secondary to intravenous injection of meperidine analogs". Psychiatry Research. 1 (3): 249–254. doi:10.1016/0165-1781(79)90006-4. PMID 298352. S2CID 44304872.
Jackson-Lewis, V.; Przedborski, S. (2007). "Protocol for the MPTP Mouse Model of Parkinson's Disease". Nature Protocols. 2 (1): 141–151. doi:10.1038/nprot.2006.342. PMID 17401348. S2CID 39743261.
Lee, J.; Ziering, A.; Heineman, S. D.; Berger, L. (1947). "Piperidine Derivatives. Part II. 2-Phenyl- and 2-Phenylalkyl-Piperidines". Journal of Organic Chemistry. 12 (6): 885–893. doi:10.1021/jo01170a021. PMID 18919741.
Maret G, Testa B, Jenner P, el Tayar N, Carrupt PA (1990). "The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism". Drug Metab Rev. 22 (4): 291–332. doi:10.3109/03602539009041087. PMID 2253555.
Manaye KF, Sonsalla PK, Barnett G, Heikkila RE, Woodward DJ, Smith WK, German DC (July 1989). "1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP)-induced degeneration of mesostriatal dopaminergic neurons in the mouse: biochemical and neuroanatomical studies". Brain Res. 491 (2): 307–315. doi:10.1016/0006-8993(89)90065-6. PMID 2765888.
Andrews AM, Murphy DL (March 1993). "Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP". J Neurochem. 60 (3): 1167–1170. doi:10.1111/j.1471-4159.1993.tb03271.x. PMID 8094744.

ndineuroscience.com (Global: low place; English: low place)

"Parkinson's Disease Models" (PDF). Neuro Detective International. Retrieved 2012-03-06.

nih.gov (Global: 5^th place; English: 5^th place)

pubmed.ncbi.nlm.nih.gov

Duty, Susan; Jenner, Peter (2011). "Animal models of Parkinson's disease: A source of novel treatments and clues to the cause of the disease". British Journal of Pharmacology. 164 (4): 1357–1391. doi:10.1111/j.1476-5381.2011.01426.x. PMC 3229766. PMID 21486284.
Narmashiri, Abdolvahed; Abbaszadeh, Mojtaba; Ghazizadeh, Ali (2022). "The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis". Neuroscience & Biobehavioral Reviews. 140 104792. doi:10.1016/j.neubiorev.2022.104792. PMID 35872230. S2CID 250929452.
Frim, D. M.; Uhler, T. A.; Galpern, W. R.; Beal, M. F.; Breakefield, X. O.; Isacson, O. (1994). "Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat". Proceedings of the National Academy of Sciences. 91 (11): 5104–5108. Bibcode:1994PNAS...91.5104F. doi:10.1073/pnas.91.11.5104. PMC 43940. PMID 8197193.
Richardson, Jason (2005). "Richardson, Jason R., et al. "Paraquat neurotoxicity is distinct from that of MPTP and rotenone". Toxicological Sciences. 88 (1): 193–201. doi:10.1093/toxsci/kfi304. PMID 16141438.
Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ (1979). "Chronic parkinsonism secondary to intravenous injection of meperidine analogs". Psychiatry Research. 1 (3): 249–254. doi:10.1016/0165-1781(79)90006-4. PMID 298352. S2CID 44304872.
Jackson-Lewis, V.; Przedborski, S. (2007). "Protocol for the MPTP Mouse Model of Parkinson's Disease". Nature Protocols. 2 (1): 141–151. doi:10.1038/nprot.2006.342. PMID 17401348. S2CID 39743261.
Lee, J.; Ziering, A.; Heineman, S. D.; Berger, L. (1947). "Piperidine Derivatives. Part II. 2-Phenyl- and 2-Phenylalkyl-Piperidines". Journal of Organic Chemistry. 12 (6): 885–893. doi:10.1021/jo01170a021. PMID 18919741.
Maret G, Testa B, Jenner P, el Tayar N, Carrupt PA (1990). "The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism". Drug Metab Rev. 22 (4): 291–332. doi:10.3109/03602539009041087. PMID 2253555.
Manaye KF, Sonsalla PK, Barnett G, Heikkila RE, Woodward DJ, Smith WK, German DC (July 1989). "1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP)-induced degeneration of mesostriatal dopaminergic neurons in the mouse: biochemical and neuroanatomical studies". Brain Res. 491 (2): 307–315. doi:10.1016/0006-8993(89)90065-6. PMID 2765888.
Andrews AM, Murphy DL (March 1993). "Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP". J Neurochem. 60 (3): 1167–1170. doi:10.1111/j.1471-4159.1993.tb03271.x. PMID 8094744.
Castagnoli N, Castagnoli KP, Van der Schyf CJ, Usuki E, Igarashi K, Steyn SJ, Riker RR (1999). "Enzyme-catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins". Pol J Pharmacol. 51 (1): 31–38. PMID 10389142.

ncbi.nlm.nih.gov

Duty, Susan; Jenner, Peter (2011). "Animal models of Parkinson's disease: A source of novel treatments and clues to the cause of the disease". British Journal of Pharmacology. 164 (4): 1357–1391. doi:10.1111/j.1476-5381.2011.01426.x. PMC 3229766. PMID 21486284.
Frim, D. M.; Uhler, T. A.; Galpern, W. R.; Beal, M. F.; Breakefield, X. O.; Isacson, O. (1994). "Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat". Proceedings of the National Academy of Sciences. 91 (11): 5104–5108. Bibcode:1994PNAS...91.5104F. doi:10.1073/pnas.91.11.5104. PMC 43940. PMID 8197193.
Langston, J. W. (2002). "Chapter 30 The Impact of MPTP on Parkinson's Disease Research: Past, Present, and Future". In Factor, S. A.; Weiner, W. J. (eds.). Parkinson's Disease. Diagnosis and Clinical Management. Demos Medical Publishing.

chem.sis.nlm.nih.gov

"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine". ChemIDplus. Archived from the original on March 28, 2014.

ninds.nih.gov

"Summary of the Article by Dr. Greenamyre on Pesticides and Parkinson's Disease". National Institute of Neurological Disorders and Stroke. 9 February 2005. Archived from the original on October 16, 2007.

nytimes.com (Global: 7^th place; English: 7^th place)

timesmachine.nytimes.com

"Bogus Heroin Brings Illness on the Coast". The New York Times. 9 December 1983. Retrieved 3 September 2023.

query.nytimes.com

"Success reported using fetal tissue to repair a brain". The New York Times. 26 November 1992.

oriprobe.com (Global: low place; English: low place)

caod.oriprobe.com

Luo Qin; Peng Guoguang; Wang Jiacai; Wang Shaojun (2010). "The Establishment of Chronic Parkinson's Disease in Mouse Model Induced by MPTP". Journal of Chongqing Medical University. 2010 (8): 1149–1151. Retrieved 2012-03-06.

oup.com (Global: 292^nd place; English: 233^rd place)

academic.oup.com

Richardson, Jason (2005). "Richardson, Jason R., et al. "Paraquat neurotoxicity is distinct from that of MPTP and rotenone". Toxicological Sciences. 88 (1): 193–201. doi:10.1093/toxsci/kfi304. PMID 16141438.

semanticscholar.org (Global: 15^th place; English: 8^th place)

api.semanticscholar.org

Narmashiri, Abdolvahed; Abbaszadeh, Mojtaba; Ghazizadeh, Ali (2022). "The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis". Neuroscience & Biobehavioral Reviews. 140 104792. doi:10.1016/j.neubiorev.2022.104792. PMID 35872230. S2CID 250929452.
Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ (1979). "Chronic parkinsonism secondary to intravenous injection of meperidine analogs". Psychiatry Research. 1 (3): 249–254. doi:10.1016/0165-1781(79)90006-4. PMID 298352. S2CID 44304872.
Jackson-Lewis, V.; Przedborski, S. (2007). "Protocol for the MPTP Mouse Model of Parkinson's Disease". Nature Protocols. 2 (1): 141–151. doi:10.1038/nprot.2006.342. PMID 17401348. S2CID 39743261.

web.archive.org (Global: 1^st place; English: 1^st place)

"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine". ChemIDplus. Archived from the original on March 28, 2014.
"Pesticides and Parkinson's Disease - A Critical Review" (PDF). Institute of Environment and Health, Cranfield University. October 2005. Archived from the original (PDF) on February 27, 2008.
"Summary of the Article by Dr. Greenamyre on Pesticides and Parkinson's Disease". National Institute of Neurological Disorders and Stroke. 9 February 2005. Archived from the original on October 16, 2007.

MPTP (English Wikipedia)

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