Analysis of information sources in references of the Wikipedia article "MRNA vaccine" in English language version.
Initiation of cationic lipid-mediated mrna transfection; Concept proposal of mRNA-based drugs
Concept proposal of mRNA vaccines (1990)
When the broad range of vaccines against COVID-19 were being tested in clinical trials, only a few experts expected the unproven technology of mRNA to be the star. Within 10 months, mRNA vaccines were both the first to be approved and the most effective. Although these are the first mRNA vaccines to be approved, the story of mRNA vaccines starts more than 30 years ago, with many bumps in the road along the way. In 1990, the late physician-scientist Jon Wolff and his University of Wisconsin colleagues injected mRNA into mice, which caused cells in the mice to produce the encoded proteins. In many ways, that work served as the first step toward making a vaccine from mRNA, but there was a long way to go—and there still is, for many applications.
Initiation of cationic lipid-mediated mrna transfection; Concept proposal of mRNA-based drugs
Concept proposal of mRNA vaccines (1990)
Initiation of cationic lipid-mediated mrna transfection; Concept proposal of mRNA-based drugs
Concept proposal of mRNA vaccines (1990)
When the broad range of vaccines against COVID-19 were being tested in clinical trials, only a few experts expected the unproven technology of mRNA to be the star. Within 10 months, mRNA vaccines were both the first to be approved and the most effective. Although these are the first mRNA vaccines to be approved, the story of mRNA vaccines starts more than 30 years ago, with many bumps in the road along the way. In 1990, the late physician-scientist Jon Wolff and his University of Wisconsin colleagues injected mRNA into mice, which caused cells in the mice to produce the encoded proteins. In many ways, that work served as the first step toward making a vaccine from mRNA, but there was a long way to go—and there still is, for many applications.