Mechanism of action of aspirin (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Mechanism of action of aspirin" in English language version.

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24nih.gov

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17doi.org

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2semanticscholar.org

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2web.archive.org

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1harvard.edu

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1americanheart.org

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1jci.org

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1worldcat.org

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americanheart.org

"Aspirin in Heart Attack and Stroke Prevention". American Heart Association. Archived from the original on 1 November 2004. The American Heart Association recommends aspirin use for patients who've had a myocardial infarction (heart attack), unstable angina, ischemic stroke (caused by blood clot) or transient ischemic attacks (TIAs or "little strokes"), if not contraindicated. This recommendation is based on sound evidence from clinical trials showing that aspirin helps prevent the recurrence of such events as heart attack, hospitalization for recurrent angina, second strokes, etc. (secondary prevention). Studies show aspirin also helps prevent these events from occurring in people at high risk (primary prevention).

doi.org

Tóth L, Muszbek L, Komáromi I (March 2013). "Mechanism of the irreversible inhibition of human cyclooxygenase-1 by aspirin as predicted by QM/MM calculations". Journal of Molecular Graphics & Modelling. 40: 99–109. doi:10.1016/j.jmgm.2012.12.013. PMID 23384979.
Giménez-Bastida JA, Boeglin WE, Boutaud O, Malkowski MG, Schneider C (January 2019). "Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation". FASEB Journal. 33 (1): 1033–1041. doi:10.1096/fj.201801018R. PMC 6355089. PMID 30096040.
Jörgensen TG, Weis-Fogh US, Nielsen HH, Olesen HP (November 1976). "Salicylate- and aspirin-induced uncoupling of oxidative phosphorylation in mitochondria isolated from the mucosal membrane of the stomach". Scandinavian Journal of Clinical and Laboratory Investigation. 36 (7): 649–654. doi:10.1080/00365517609054490. PMID 1019575.
Vane JR, Botting RM (June 2003). "The mechanism of action of aspirin". Thrombosis Research. 110 (5–6): 255–258. doi:10.1016/S0049-3848(03)00379-7. PMID 14592543.
Kerola M, Vuolteenaho K, Kosonen O, Kankaanranta H, Sarna S, Moilanen E (January 2009). "Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo". Basic & Clinical Pharmacology & Toxicology. 104 (1): 17–21. doi:10.1111/j.1742-7843.2008.00332.x. PMID 19152549.
Vane JR, Botting RM (June 2003). "The mechanism of action of aspirin". Thrombosis Research. In Honour of Sir John Vane, F.R.S., Nobel laureate, the Discoverer of the Machanism of Action of Aspirin, Krakow, 31 May-3 June 2003. 110 (5–6): 255–258. doi:10.1016/S0049-3848(03)00379-7. PMID 14592543.
Chandrasekharan JA, Sharma-Walia N (September 2015). "Lipoxins: nature's way to resolve inflammation". Journal of Inflammation Research. 8: 181–192. doi:10.2147/JIR.S90380. PMC 4598198. PMID 26457057.
Warner TD, Mitchell JA (October 2002). "Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13371–13373. Bibcode:2002PNAS...9913371W. doi:10.1073/pnas.222543099. PMC 129677. PMID 12374850.
Varga Z, Sabzwari SR, Vargova V (April 2017). "Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue". Cureus. 9 (4): e1144. doi:10.7759/cureus.1144. PMC 5422108. PMID 28491485.
Peng N, Guo L, Wei Z, Wang X, Zhao L, Kang L, et al. (November 2023). "Platelet mitochondrial DNA methylation: A novel biomarker for myocardial infarction - A preliminary study". International Journal of Cardiology. 398: 131606. doi:10.1016/j.ijcard.2023.131606. PMID 37996014. S2CID 265395351.
Szczuko M, Kozioł I, Kotlęga D, Brodowski J, Drozd A (October 2021). "The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review". International Journal of Molecular Sciences. 22 (21): 11644. doi:10.3390/ijms222111644. PMC 8584264. PMID 34769074.
Smith, William L.; Langenbach, Robert (2001-06-15). "Why there are two cyclooxygenase isozymes". The Journal of Clinical Investigation. 107 (12): 1491–1495. doi:10.1172/JCI13271. ISSN 0021-9738. PMC 200199. PMID 11413152.
Tohgi H, Konno S, Tamura K, Kimura B, Kawano K (October 1992). "Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin". Stroke. 23 (10): 1400–1403. doi:10.1161/01.STR.23.10.1400. PMID 1412574. S2CID 14177039.
Amrein PC, Ellman L, Harris WH (May 1981). "Aspirin-induced prolongation of bleeding time and perioperative blood loss". JAMA. 245 (18): 1825–1828. doi:10.1001/jama.1981.03310430017013. PMID 7014935.
Somasundaram S, Sigthorsson G, Simpson RJ, Watts J, Jacob M, Tavares IA, et al. (May 2000). "Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat". Alimentary Pharmacology & Therapeutics. 14 (5): 639–650. doi:10.1046/j.1365-2036.2000.00723.x. PMID 10792129.
Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW (July 2004). "15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation". The Journal of Experimental Medicine. 200 (1): 69–78. doi:10.1084/jem.20040566. PMC 2213311. PMID 15238606.
McCarty MF, Block KI (September 2006). "Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy". Integrative Cancer Therapies. 5 (3): 252–268. doi:10.1177/1534735406291499. PMID 16880431.

harvard.edu

ui.adsabs.harvard.edu

Warner TD, Mitchell JA (October 2002). "Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13371–13373. Bibcode:2002PNAS...9913371W. doi:10.1073/pnas.222543099. PMC 129677. PMID 12374850.

jci.org

Smith, William L.; Langenbach, Robert (2001-06-15). "Why there are two cyclooxygenase isozymes". The Journal of Clinical Investigation. 107 (12): 1491–1495. doi:10.1172/JCI13271. ISSN 0021-9738. PMC 200199. PMID 11413152.

nih.gov

pubmed.ncbi.nlm.nih.gov

Tóth L, Muszbek L, Komáromi I (March 2013). "Mechanism of the irreversible inhibition of human cyclooxygenase-1 by aspirin as predicted by QM/MM calculations". Journal of Molecular Graphics & Modelling. 40: 99–109. doi:10.1016/j.jmgm.2012.12.013. PMID 23384979.
Giménez-Bastida JA, Boeglin WE, Boutaud O, Malkowski MG, Schneider C (January 2019). "Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation". FASEB Journal. 33 (1): 1033–1041. doi:10.1096/fj.201801018R. PMC 6355089. PMID 30096040.
Jörgensen TG, Weis-Fogh US, Nielsen HH, Olesen HP (November 1976). "Salicylate- and aspirin-induced uncoupling of oxidative phosphorylation in mitochondria isolated from the mucosal membrane of the stomach". Scandinavian Journal of Clinical and Laboratory Investigation. 36 (7): 649–654. doi:10.1080/00365517609054490. PMID 1019575.
Vane JR, Botting RM (June 2003). "The mechanism of action of aspirin". Thrombosis Research. 110 (5–6): 255–258. doi:10.1016/S0049-3848(03)00379-7. PMID 14592543.
Kerola M, Vuolteenaho K, Kosonen O, Kankaanranta H, Sarna S, Moilanen E (January 2009). "Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo". Basic & Clinical Pharmacology & Toxicology. 104 (1): 17–21. doi:10.1111/j.1742-7843.2008.00332.x. PMID 19152549.
Vane JR, Botting RM (June 2003). "The mechanism of action of aspirin". Thrombosis Research. In Honour of Sir John Vane, F.R.S., Nobel laureate, the Discoverer of the Machanism of Action of Aspirin, Krakow, 31 May-3 June 2003. 110 (5–6): 255–258. doi:10.1016/S0049-3848(03)00379-7. PMID 14592543.
Chandrasekharan JA, Sharma-Walia N (September 2015). "Lipoxins: nature's way to resolve inflammation". Journal of Inflammation Research. 8: 181–192. doi:10.2147/JIR.S90380. PMC 4598198. PMID 26457057.
Warner TD, Mitchell JA (October 2002). "Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13371–13373. Bibcode:2002PNAS...9913371W. doi:10.1073/pnas.222543099. PMC 129677. PMID 12374850.
Varga Z, Sabzwari SR, Vargova V (April 2017). "Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue". Cureus. 9 (4): e1144. doi:10.7759/cureus.1144. PMC 5422108. PMID 28491485.
Peng N, Guo L, Wei Z, Wang X, Zhao L, Kang L, et al. (November 2023). "Platelet mitochondrial DNA methylation: A novel biomarker for myocardial infarction - A preliminary study". International Journal of Cardiology. 398: 131606. doi:10.1016/j.ijcard.2023.131606. PMID 37996014. S2CID 265395351.
Szczuko M, Kozioł I, Kotlęga D, Brodowski J, Drozd A (October 2021). "The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review". International Journal of Molecular Sciences. 22 (21): 11644. doi:10.3390/ijms222111644. PMC 8584264. PMID 34769074.
Smith, William L.; Langenbach, Robert (2001-06-15). "Why there are two cyclooxygenase isozymes". The Journal of Clinical Investigation. 107 (12): 1491–1495. doi:10.1172/JCI13271. ISSN 0021-9738. PMC 200199. PMID 11413152.
Tohgi H, Konno S, Tamura K, Kimura B, Kawano K (October 1992). "Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin". Stroke. 23 (10): 1400–1403. doi:10.1161/01.STR.23.10.1400. PMID 1412574. S2CID 14177039.
Amrein PC, Ellman L, Harris WH (May 1981). "Aspirin-induced prolongation of bleeding time and perioperative blood loss". JAMA. 245 (18): 1825–1828. doi:10.1001/jama.1981.03310430017013. PMID 7014935.
Somasundaram S, Sigthorsson G, Simpson RJ, Watts J, Jacob M, Tavares IA, et al. (May 2000). "Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat". Alimentary Pharmacology & Therapeutics. 14 (5): 639–650. doi:10.1046/j.1365-2036.2000.00723.x. PMID 10792129.
Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW (July 2004). "15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation". The Journal of Experimental Medicine. 200 (1): 69–78. doi:10.1084/jem.20040566. PMC 2213311. PMID 15238606.
McCarty MF, Block KI (September 2006). "Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy". Integrative Cancer Therapies. 5 (3): 252–268. doi:10.1177/1534735406291499. PMID 16880431.

ncbi.nlm.nih.gov

Giménez-Bastida JA, Boeglin WE, Boutaud O, Malkowski MG, Schneider C (January 2019). "Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15 R-prostaglandins that inhibit platelet aggregation". FASEB Journal. 33 (1): 1033–1041. doi:10.1096/fj.201801018R. PMC 6355089. PMID 30096040.
Chandrasekharan JA, Sharma-Walia N (September 2015). "Lipoxins: nature's way to resolve inflammation". Journal of Inflammation Research. 8: 181–192. doi:10.2147/JIR.S90380. PMC 4598198. PMID 26457057.
Warner TD, Mitchell JA (October 2002). "Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13371–13373. Bibcode:2002PNAS...9913371W. doi:10.1073/pnas.222543099. PMC 129677. PMID 12374850.
Varga Z, Sabzwari SR, Vargova V (April 2017). "Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue". Cureus. 9 (4): e1144. doi:10.7759/cureus.1144. PMC 5422108. PMID 28491485.
Szczuko M, Kozioł I, Kotlęga D, Brodowski J, Drozd A (October 2021). "The Role of Thromboxane in the Course and Treatment of Ischemic Stroke: Review". International Journal of Molecular Sciences. 22 (21): 11644. doi:10.3390/ijms222111644. PMC 8584264. PMID 34769074.
Smith, William L.; Langenbach, Robert (2001-06-15). "Why there are two cyclooxygenase isozymes". The Journal of Clinical Investigation. 107 (12): 1491–1495. doi:10.1172/JCI13271. ISSN 0021-9738. PMC 200199. PMID 11413152.
Paul-Clark MJ, Van Cao T, Moradi-Bidhendi N, Cooper D, Gilroy DW (July 2004). "15-epi-lipoxin A4-mediated induction of nitric oxide explains how aspirin inhibits acute inflammation". The Journal of Experimental Medicine. 200 (1): 69–78. doi:10.1084/jem.20040566. PMC 2213311. PMID 15238606.

semanticscholar.org

api.semanticscholar.org

Peng N, Guo L, Wei Z, Wang X, Zhao L, Kang L, et al. (November 2023). "Platelet mitochondrial DNA methylation: A novel biomarker for myocardial infarction - A preliminary study". International Journal of Cardiology. 398: 131606. doi:10.1016/j.ijcard.2023.131606. PMID 37996014. S2CID 265395351.
Tohgi H, Konno S, Tamura K, Kimura B, Kawano K (October 1992). "Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin". Stroke. 23 (10): 1400–1403. doi:10.1161/01.STR.23.10.1400. PMID 1412574. S2CID 14177039.

web.archive.org

"Aspirin in Heart Attack and Stroke Prevention". American Heart Association. Archived from the original on 1 November 2004. The American Heart Association recommends aspirin use for patients who've had a myocardial infarction (heart attack), unstable angina, ischemic stroke (caused by blood clot) or transient ischemic attacks (TIAs or "little strokes"), if not contraindicated. This recommendation is based on sound evidence from clinical trials showing that aspirin helps prevent the recurrence of such events as heart attack, hospitalization for recurrent angina, second strokes, etc. (secondary prevention). Studies show aspirin also helps prevent these events from occurring in people at high risk (primary prevention).
"Reye syndrome" at Dorland's Medical Dictionary

worldcat.org

search.worldcat.org

Smith, William L.; Langenbach, Robert (2001-06-15). "Why there are two cyclooxygenase isozymes". The Journal of Clinical Investigation. 107 (12): 1491–1495. doi:10.1172/JCI13271. ISSN 0021-9738. PMC 200199. PMID 11413152.