Analysis of information sources in references of the Wikipedia article "Meta-Chlorophenylpiperazine" in English language version.
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{{cite journal}}: CS1 maint: deprecated archival service (link)The anxiety-producing effects of mCPP are likely mediated by serotonin receptors, as the nonselective 5-HT antagonists methysergide and metergoline both attenuate these effects of mCPP in humans (Kalus et al., 1990). Further, the selective serotonin reuptake inhibitors (SSRIs) clomipramine and fluoxetine both reverse the exacerbation of anxiety and obsessive-compulsive symptoms produced by mCPP (Hollander et al., 1991; Zohar et al., 1988). On the other hand, 5-HT3 antagonists have no effect (Broocks et al., 2001; Silverstone and Cowen, 1994), but then do not have very robust effects against anxiety in general (Gatch and Lal, 2001). Benzodiazepines are also used to treat anxiety, but the only benzodiazepine that has been tested against mCPP is alprazolam, which blocked the anxiety-producing effects of mCPP in non-psychiatric subjects (Sevy et al., 1994).
It is now well known that a number of non-psychedelic medications and their active metabolites including [...] the trazodone metabolite m-CPP [93] and other drugs are potent 5-HT2A agonists. Importantly, these medications are devoid of psychedelic drug-like actions in humans at typical therapeutic doses although hallucinations have occasionally been reported when large doses of [...] m-CPP [95] have been administered.
Table II. Affinities of Selected Phenalkylamines for 5-HT1 and 5-HT2 Binding Sites
A case report, however, suggested that an mCPP-induced panic attack could be blocked by both metergoline and methysergide (Kalus et al 1991).
{{cite journal}}: CS1 maint: deprecated archival service (link)The anxiety-producing effects of mCPP are likely mediated by serotonin receptors, as the nonselective 5-HT antagonists methysergide and metergoline both attenuate these effects of mCPP in humans (Kalus et al., 1990). Further, the selective serotonin reuptake inhibitors (SSRIs) clomipramine and fluoxetine both reverse the exacerbation of anxiety and obsessive-compulsive symptoms produced by mCPP (Hollander et al., 1991; Zohar et al., 1988). On the other hand, 5-HT3 antagonists have no effect (Broocks et al., 2001; Silverstone and Cowen, 1994), but then do not have very robust effects against anxiety in general (Gatch and Lal, 2001). Benzodiazepines are also used to treat anxiety, but the only benzodiazepine that has been tested against mCPP is alprazolam, which blocked the anxiety-producing effects of mCPP in non-psychiatric subjects (Sevy et al., 1994).
It is now well known that a number of non-psychedelic medications and their active metabolites including [...] the trazodone metabolite m-CPP [93] and other drugs are potent 5-HT2A agonists. Importantly, these medications are devoid of psychedelic drug-like actions in humans at typical therapeutic doses although hallucinations have occasionally been reported when large doses of [...] m-CPP [95] have been administered.
Table II. Affinities of Selected Phenalkylamines for 5-HT1 and 5-HT2 Binding Sites
A case report, however, suggested that an mCPP-induced panic attack could be blocked by both metergoline and methysergide (Kalus et al 1991).
It is now well known that a number of non-psychedelic medications and their active metabolites including [...] the trazodone metabolite m-CPP [93] and other drugs are potent 5-HT2A agonists. Importantly, these medications are devoid of psychedelic drug-like actions in humans at typical therapeutic doses although hallucinations have occasionally been reported when large doses of [...] m-CPP [95] have been administered.
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