Metformin (English Wikipedia)

"Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Archived from the original on 30 September 2024. Retrieved 30 September 2024.

archive.org (Global: 6^th place; English: 6^th place)

Maharani U (2009). "Chapter 27: Diabetes Mellitus & Hypoglycemia". In Papadakis MA, McPhee SJ (eds.). Current Medical Diagnosis and Treatment 2010 (49th ed.). McGraw-Hill Medical. pp. 1092–93. ISBN 978-0-07-162444-2.

aspca.org (Global: low place; English: low place)

Heller JB (2007). "Metformin overdose in dogs and cats" (PDF). Veterinary Medicine (April): 231–33. Archived from the original (PDF) on 23 October 2007.

bbc.co.uk (Global: 11^th place; English: 10^th place)

"Call to 'suspend' diabetes drug". BBC News Online. 23 September 2010. Archived from the original on 24 September 2010.

bloomberg.com (Global: 118^th place; English: 85^th place)

"Glaxo's Avandia Cleared From Sales Restrictions by FDA". Bloomberg. Archived from the original on 9 November 2014.

books.google.com (Global: 3^rd place; English: 3^rd place)

Fischer J (2010). Analogue-based Drug Discovery II. John Wiley & Sons. p. 49. ISBN 978-3-527-63212-1. Archived from the original on 8 September 2017.
Stargrove MB, Treasure J, McKee DL (2008). Herb, nutrient, and drug interactions: clinical implications and therapeutic strategies. St. Louis, Mo.: Mosby/Elsevier. p. 217. ISBN 978-0-323-02964-3. Archived from the original on 8 September 2017.

canada.ca (Global: 1,114^th place; English: 605^th place)

health-products.canada.ca

"Metformin Hydrochloride". Health Canada. Archived from the original on 6 March 2023. Retrieved 6 March 2023.

cdsco.nic.in (Global: low place; English: low place)

"Drugs banned in India". Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India. Archived from the original on 21 February 2015. Retrieved 17 September 2013.

chemsrc.com (Global: low place; English: low place)

"Metformin". www.chemsrc.com. Archived from the original on 12 June 2017. Retrieved 10 May 2018.

clincalc.com (Global: 5,833^rd place; English: 4,432^nd place)

"The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
"Metformin Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 12 August 2025.

cochrane.org (Global: low place; English: low place)

"Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus | Cochrane". www.cochrane.org. Retrieved 30 August 2026.

docguide.com (Global: low place; English: low place)

"FDA Approves GlaxoSmithKline's Avandamet (rosiglitazone maleate and metformin HCl), The Latest Advancement in the Treatment of Type 2 Diabetes" (Press release). GlaxoSmithKline. 12 October 2002. Archived from the original on 21 January 2007. Retrieved 27 December 2006.

doi.org (Global: 2^nd place; English: 2^nd place)

Sirtori CR, Franceschini G, Galli-Kienle M, Cighetti G, Galli G, Bondioli A, et al. (December 1978). "Disposition of metformin (N,N-dimethylbiguanide) in man". Clinical Pharmacology and Therapeutics. 24 (6): 683–93. doi:10.1002/cpt1978246683. PMID 710026. S2CID 24531910.
Dunn CJ, Peters DH (May 1995). "Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus". Drugs. 49 (5): 721–49. doi:10.2165/00003495-199549050-00007. PMID 7601013.
Hundal RS, Inzucchi SE (2003). "Metformin: new understandings, new uses". Drugs. 63 (18): 1879–94. doi:10.2165/00003495-200363180-00001. PMID 12930161.
Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, Freeman R, et al. (January 2022). "9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022". Diabetes Care. 45 (Suppl 1): S125–S143. doi:10.2337/dc22-s009. PMID 34964831. S2CID 245538347.
Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. (January 2020). "2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD". European Heart Journal. 41 (2): 255–323. doi:10.1093/eurheartj/ehz486. hdl:2158/1181259. PMID 31497854.
Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z, et al. (June 2016). "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis". Annals of Internal Medicine. 164 (11): 740–751. doi:10.7326/M15-2650. PMID 27088241. S2CID 32016657.
de Silva VA, Suraweera C, Ratnatunga SS, Dayabandara M, Wanniarachchi N, Hanwella R (October 2016). "Metformin in prevention and treatment of antipsychotic-induced weight gain: a systematic review and meta-analysis". BMC Psychiatry. 16 (1) 341. doi:10.1186/s12888-016-1049-5. PMC 5048618. PMID 27716110.
Lin H, Ao H, Guo G, Liu M (2023). "The Role and Mechanism of Metformin in Inflammatory Diseases". Journal of Inflammation Research. 16: 5545–5564. doi:10.2147/JIR.S436147. PMC 10680465. PMID 38026260.
Saisho Y (March 2015). "Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect". Endocrine, Metabolic & Immune Disorders Drug Targets. 15 (3): 196–205. doi:10.2174/1871530315666150316124019. PMID 25772174.
Triggle CR, Ding H (January 2017). "Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium". Acta Physiologica. 219 (1): 138–151. doi:10.1111/apha.12644. PMID 26680745. S2CID 312517.
Blumenberg A, Benabbas R, Sinert R, Jeng A, Wiener SW (April 2020). "Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA". Journal of Medical Toxicology. 16 (2): 222–229. doi:10.1007/s13181-019-00755-6. PMC 7099117. PMID 31907741.
Lipska KJ, Bailey CJ, Inzucchi SE (June 2011). "Use of metformin in the setting of mild-to-moderate renal insufficiency". Diabetes Care. 34 (6): 1431–7. doi:10.2337/dc10-2361. PMC 3114336. PMID 21617112.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, et al. (February 2020). "GDF15 mediates the effects of metformin on body weight and energy balance". Nature. 578 (7795): 444–448. Bibcode:2020Natur.578..444C. doi:10.1038/s41586-019-1911-y. PMC 7234839. PMID 31875646.
Day EA, Ford RJ, Smith BK, Mohammadi-Shemirani P, Morrow MR, Gutgesell RM, et al. (December 2019). "Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss". Nature Metabolism. 1 (12): 1202–1208. doi:10.1038/s42255-019-0146-4. PMID 32694673. S2CID 213199603.
Pappachan JM, Viswanath AK (January 2017). "Medical Management of Diabesity: Do We Have Realistic Targets?". Current Diabetes Reports. 17 (1) 4. doi:10.1007/s11892-017-0828-9. PMID 28101792. S2CID 10289148.
LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, et al. (March 2022). "Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis". Proceedings of the National Academy of Sciences of the United States of America. 119 (10) e2122287119. Bibcode:2022PNAS..11922287L. doi:10.1073/pnas.2122287119. PMC 8916010. PMID 35238637.
Lord JM, Flight IH, Norman RJ (October 2003). "Metformin in polycystic ovary syndrome: systematic review and meta-analysis". BMJ. 327 (7421): 951–3. doi:10.1136/bmj.327.7421.951. PMC 259161. PMID 14576245.
Bennett WL, Maruthur NM, Singh S, Segal JB, Wilson LM, Chatterjee R, et al. (May 2011). "Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations". Annals of Internal Medicine. 154 (9): 602–13. doi:10.7326/0003-4819-154-9-201105030-00336. PMC 3733115. PMID 21403054.
Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. (June 2012). "Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)". Diabetes Care. 35 (6): 1364–79. doi:10.2337/dc12-0413. PMC 3357214. PMID 22517736.
Qaseem A, Humphrey LL, Sweet DE, Starkey M, Shekelle P (February 2012). "Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians". Annals of Internal Medicine. 156 (3): 218–31. doi:10.7326/0003-4819-156-3-201202070-00011. PMID 22312141.
Jia Y, Lao Y, Zhu H, Li N, Leung SW (January 2019). "Is metformin still the most efficacious first-line oral hypoglycaemic drug in treating type 2 diabetes? A network meta-analysis of randomized controlled trials". Obesity Reviews. 20 (1): 1–12. doi:10.1111/obr.12753. PMID 30230172.
Golay A (January 2008). "Metformin and body weight". International Journal of Obesity. 32 (1): 61–72. doi:10.1038/sj.ijo.0803695. PMID 17653063.
Mead E, Atkinson G, Richter B, Metzendorf MI, Baur L, Finer N, et al. (November 2016). "Drug interventions for the treatment of obesity in children and adolescents". The Cochrane Database of Systematic Reviews. 11 (11) CD012436. doi:10.1002/14651858.CD012436. hdl:10149/620651. PMC 6472619. PMID 27899001.
Bolen S, Feldman L, Vassy J, Wilson L, Yeh HC, Marinopoulos S, et al. (September 2007). "Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus". Annals of Internal Medicine. 147 (6): 386–399. doi:10.7326/0003-4819-147-6-200709180-00178. PMID 17638715.
Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B, et al. (Cochrane Metabolic and Endocrine Disorders Group) (December 2019). "Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 2019 (12) CD008558. doi:10.1002/14651858.CD008558.pub2. PMC 6889926. PMID 31794067.
Morley LC, Tang T, Yasmin E, Norman RJ, Balen AH (November 2017). "Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility". The Cochrane Database of Systematic Reviews. 11 (2) CD003053. doi:10.1002/14651858.CD003053.pub6. PMC 6486196. PMID 29183107. Our updated review suggests that metformin alone may be beneficial over a placebo for live birth, although the evidence quality was low.
Ghazeeri GS, Nassar AH, Younes Z, Awwad JT (June 2012). "Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview". Acta Obstetricia et Gynecologica Scandinavica. 91 (6): 658–78. doi:10.1111/j.1600-0412.2012.01385.x. PMID 22375613. S2CID 41145972.
Kumar P, Khan K (May 2012). "Effects of metformin use in pregnant patients with polycystic ovary syndrome". Journal of Human Reproductive Sciences. 5 (2): 166–9. doi:10.4103/0974-1208.101012. PMC 3493830. PMID 23162354.
Tay CT, Joham AE, Hiam DS, Gadalla MA, Pundir J, Thangaratinam S, et al. (November 2018). "Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews". Clinical Endocrinology. 89 (5): 535–553. doi:10.1111/cen.13753. hdl:10536/DRO/DU:30151483. PMID 29846959.
Tso LO, Costello MF, Albuquerque LE, Andriolo RB, Macedo CR (December 2020). "Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome". The Cochrane Database of Systematic Reviews. 2020 (12) CD006105. doi:10.1002/14651858.CD006105.pub4. PMC 8171384. PMID 33347618.
Dodd JM, Grivell RM, Deussen AR, Hague WM (July 2018). "Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes". The Cochrane Database of Systematic Reviews. 2018 (7) CD010564. doi:10.1002/14651858.CD010564.pub2. PMC 6513233. PMID 30039871.
The Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (March 2008). "Consensus on infertility treatment related to polycystic ovary syndrome". Human Reproduction. 23 (3): 462–77. doi:10.1093/humrep/dem426. PMID 18308833.
Diamanti-Kandarakis E, Economou F, Palimeri S, Christakou C (September 2010). "Metformin in polycystic ovary syndrome". Annals of the New York Academy of Sciences. 1205 (1): 192–8. Bibcode:2010NYASA1205..192D. doi:10.1111/j.1749-6632.2010.05679.x. PMID 20840272. S2CID 44203632.
Diamanti-Kandarakis E, Christakou CD, Kandaraki E, Economou FN (February 2010). "Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome". European Journal of Endocrinology. 162 (2): 193–212. doi:10.1530/EJE-09-0733. PMID 19841045.
Butalia S, Gutierrez L, Lodha A, Aitken E, Zakariasen A, Donovan L (January 2017). "Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis". Diabetic Medicine. 34 (1): 27–36. doi:10.1111/dme.13150. PMID 27150509. S2CID 3418227.
Nicholson W, Bolen S, Witkop CT, Neale D, Wilson L, Bass E (January 2009). "Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review". Obstetrics and Gynecology. 113 (1): 193–205. doi:10.1097/AOG.0b013e318190a459. PMID 19104375. S2CID 28115952.
Kitwitee P, Limwattananon S, Limwattananon C, Waleekachonlert O, Ratanachotpanich T, Phimphilai M, et al. (September 2015). "Metformin for the treatment of gestational diabetes: An updated meta-analysis". Diabetes Research and Clinical Practice. 109 (3): 521–32. doi:10.1016/j.diabres.2015.05.017. PMID 26117686.
Balsells M, García-Patterson A, Solà I, Roqué M, Gich I, Corcoy R (January 2015). "Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis". BMJ (Systematic Review & Meta-Analysis). 350: h102. doi:10.1136/bmj.h102. PMC 4301599. PMID 25609400.
Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, et al. (February 2018). "Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis". Diabetic Medicine. 35 (2): 160–172. doi:10.1111/dme.13523. hdl:10453/130987. PMID 29044702. S2CID 40045912. Archived from the original on 29 April 2023. Retrieved 7 April 2023.
Sivalingam VN, Myers J, Nicholas S, Balen AH, Crosbie EJ (2014). "Metformin in reproductive health, pregnancy and gynaecological cancer: established and emerging indications". Human Reproduction Update. 20 (6): 853–68. doi:10.1093/humupd/dmu037. PMID 25013215.
Tarry-Adkins JL, Aiken CE, Ozanne SE (August 2019). "Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis". PLOS Medicine. 16 (8) e1002848. doi:10.1371/journal.pmed.1002848. PMC 6684046. PMID 31386659.
Dutta D, Sharma M, Nagendra L, Bhattacharya S, Mohindra R, Yajnik CS (September 2024). "Long-Term Impact on Offspring (5 to 11 Years of Age) of Metformin Use in Pregnancy in Mothers With Diabetes: A Systematic Review and Meta-Analysis". Endocrine Practice. 30 (9): 854–862. doi:10.1016/j.eprac.2024.05.017. PMID 38876183.
Yerevanian A, Soukas AA (June 2019). "Metformin: Mechanisms in Human Obesity and Weight Loss". Current Obesity Reports. 8 (2): 156–164. doi:10.1007/s13679-019-00335-3. PMC 6520185. PMID 30874963.
Choi YJ (2015). "Efficacy of adjunctive treatments added to olanzapine or clozapine for weight control in patients with schizophrenia: a systematic review and meta-analysis". TheScientificWorldJournal. 2015 970730. doi:10.1155/2015/970730. PMC 4310265. PMID 25664341.
Praharaj SK, Jana AK, Goyal N, Sinha VK (March 2011). "Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis". British Journal of Clinical Pharmacology. 71 (3): 377–82. doi:10.1111/j.1365-2125.2010.03783.x. PMC 3045546. PMID 21284696.
Yu O, Lu M, Lai TK, Hahn M, Agarwal SM, O'Donoghue B, et al. (2024). "Metformin co-commencement at time of antipsychotic initiation for attenuation of weight gain: a systematic review and meta-analysis". Therapeutic Advances in Psychopharmacology. 14 20451253241255476. doi:10.1177/20451253241255476. PMC 11141220. PMID 38827016.
Siskind DJ, Leung J, Russell AW, Wysoczanski D, Kisely S (2016). "Metformin for Clozapine Associated Obesity: A Systematic Review and Meta-Analysis". PLOS ONE. 11 (6) e0156208. Bibcode:2016PLoSO..1156208S. doi:10.1371/journal.pone.0156208. PMC 4909277. PMID 27304831.
Vella S, Buetow L, Royle P, Livingstone S, Colhoun HM, Petrie JR (May 2010). "The use of metformin in type 1 diabetes: a systematic review of efficacy". Diabetologia. 53 (5): 809–20. doi:10.1007/s00125-009-1636-9. PMID 20057994.
Mohamed S (October 2024). "Metformin: Diverse molecular mechanisms, gastrointestinal effects and overcoming intolerance in type 2 Diabetes Mellitus: A review". Medicine. 103 (43) e40221. doi:10.1097/MD.0000000000040221. PMC 11521032. PMID 39470509.
Khurana R, Malik IS (January 2010). "Metformin: safety in cardiac patients". Heart. 96 (2): 99–102. doi:10.1136/hrt.2009.173773. PMID 19564648. S2CID 9746741.
Ahmad R, Haque M (October 2024). "Metformin: Beyond Type 2 Diabetes Mellitus". Cureus. 16 (10) e71730. doi:10.7759/cureus.71730. PMC 11486535. PMID 39421288.
Heaf J (June 2014). "Metformin in chronic kidney disease: time for a rethink". Peritoneal Dialysis International. 34 (4): 353–357. doi:10.3747/pdi.2013.00344. PMC 4079480. PMID 24711640.
Nabrdalik K, Hendel M, Irlik K, Kwiendacz H, Łoniewski I, Bucci T, et al. (September 2024). "Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies". BMC Endocrine Disorders. 24 (1) 206. doi:10.1186/s12902-024-01727-w. PMC 11440709. PMID 39350158.
Fujita Y, Inagaki N (January 2017). "Metformin: New Preparations and Nonglycemic Benefits". Current Diabetes Reports. 17 (1) 5. doi:10.1007/s11892-017-0829-8. PMID 28116648. S2CID 9277684.
Wulffelé MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, et al. (November 2003). "Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial". Journal of Internal Medicine. 254 (5): 455–63. doi:10.1046/j.1365-2796.2003.01213.x. PMID 14535967. S2CID 12507226.
Andrès E, Noel E, Goichot B (October 2002). "Metformin-associated vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (19): 2251–2. doi:10.1001/archinte.162.19.2251-a. PMID 12390080. Archived from the original on 10 June 2024. Retrieved 22 January 2024.
Gilligan MA (February 2002). "Metformin and vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (4): 484–5. doi:10.1001/archinte.162.4.484. PMID 11863489. Archived from the original on 1 December 2020. Retrieved 22 January 2024.
de Jager J, Kooy A, Lehert P, Wulffelé MG, van der Kolk J, Bets D, et al. (May 2010). "Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial". BMJ. 340 c2181. doi:10.1136/bmj.c2181. PMC 2874129. PMID 20488910.
Ting RZ, Szeto CC, Chan MH, Ma KK, Chow KM (October 2006). "Risk factors of vitamin B(12) deficiency in patients receiving metformin". Archives of Internal Medicine. 166 (18): 1975–9. doi:10.1001/archinte.166.18.1975. PMID 17030830.
Ramzan NU, Shahjahan K, Dhillon RA, Khan NT, Hashmat MB, Anwer MU, et al. (September 2024). "Vitamin B12 Deficiency in Patients Taking Metformin: Pathogenesis and Recommendations". Cureus. 16 (9) e68550. doi:10.7759/cureus.68550. PMC 11374140. PMID 39233729.
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK (2014). "Metformin in patients with type 2 diabetes and kidney disease: a systematic review". JAMA. 312 (24): 2668–75. doi:10.1001/jama.2014.15298. PMC 4427053. PMID 25536258.
Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. (January 2009). "Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes". Diabetologia. 52 (1): 17–30. doi:10.1007/s00125-008-1157-y. PMID 18941734.
Stang M, Wysowski DK, Butler-Jones D (June 1999). "Incidence of lactic acidosis in metformin users". Diabetes Care. 22 (6): 925–7. doi:10.2337/diacare.22.6.925. PMID 10372243.
Salpeter SR, Greyber E, Pasternak GA, Salpeter EE (November 2003). "Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis". Archives of Internal Medicine. 163 (21): 2594–602. doi:10.1001/archinte.163.21.2594. PMID 14638559.
Kirpichnikov D, McFarlane SI, Sowers JR (July 2002). "Metformin: an update". Annals of Internal Medicine. 137 (1): 25–33. doi:10.7326/0003-4819-137-1-200207020-00009. PMID 12093242. S2CID 9140541.
Forrester MB (July 2008). "Adult metformin ingestions reported to Texas poison control centers, 2000-2006". Human & Experimental Toxicology. 27 (7): 575–83. Bibcode:2008HETox..27..575F. doi:10.1177/0960327108090589. PMID 18829734. S2CID 5413561.
Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, et al. (August 2015). "Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup". Critical Care Medicine. 43 (8): 1716–30. doi:10.1097/CCM.0000000000001002. PMID 25860205. S2CID 13861731.
Liu A, Coleman SP (November 2009). "Determination of metformin in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877 (29): 3695–700. doi:10.1016/j.jchromb.2009.09.020. PMID 19783231.
Teale KF, Devine A, Stewart H, Harper NJ (July 1998). "The management of metformin overdose". Anaesthesia. 53 (7): 698–701. doi:10.1046/j.1365-2044.1998.436-az0549.x. PMID 9771180. S2CID 45218798.
Somogyi A, Stockley C, Keal J, Rolan P, Bochner F (May 1987). "Reduction of metformin renal tubular secretion by cimetidine in man". British Journal of Clinical Pharmacology. 23 (5): 545–51. doi:10.1111/j.1365-2125.1987.tb03090.x. PMC 1386190. PMID 3593625.
Jayasagar G, Krishna Kumar M, Chandrasekhar K, Madhusudan Rao C, Madhusudan Rao Y (2002). "Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers". Drug Metabolism and Drug Interactions. 19 (1): 41–8. doi:10.1515/dmdi.2002.19.1.41. PMID 12222753. S2CID 26919498.
May M, Schindler C (April 2016). "Clinically and pharmacologically relevant interactions of antidiabetic drugs". Therapeutic Advances in Endocrinology and Metabolism. 7 (2): 69–83. doi:10.1177/2042018816638050. PMC 4821002. PMID 27092232.
Rena G, Pearson ER, Sakamoto K (September 2013). "Molecular mechanism of action of metformin: old or new insights?". Diabetologia. 56 (9): 1898–906. doi:10.1007/s00125-013-2991-0. PMC 3737434. PMID 23835523.
Burcelin R (May 2014). "The antidiabetic gutsy role of metformin uncovered?". Gut. 63 (5): 706–7. doi:10.1136/gutjnl-2013-305370. PMID 23840042. S2CID 42142919.
Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, et al. (June 2014). "Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase". Nature. 510 (7506): 542–6. Bibcode:2014Natur.510..542M. doi:10.1038/nature13270. PMC 4074244. PMID 24847880.
Vázquez-Borrego MC, Fuentes-Fayos AC, Gahete MD, Castaño JP, Kineman RD, Luque RM (2018). "The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions". Cellular Physiology and Biochemistry. 49 (4): 1444–1459. doi:10.1159/000493448. PMID 30205369.
Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, et al. (December 2000). "Mechanism by which metformin reduces glucose production in type 2 diabetes". Diabetes. 49 (12): 2063–9. doi:10.2337/diabetes.49.12.2063. PMC 2995498. PMID 11118008.
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. (October 2001). "Role of AMP-activated protein kinase in mechanism of metformin action". The Journal of Clinical Investigation. 108 (8): 1167–74. doi:10.1172/JCI13505. PMC 209533. PMID 11602624.
Towler MC, Hardie DG (February 2007). "AMP-activated protein kinase in metabolic control and insulin signaling". Circulation Research. 100 (3): 328–41. doi:10.1161/01.RES.0000256090.42690.05. PMID 17307971.
Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, et al. (February 2008). "Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP". Diabetes. 57 (2): 306–14. doi:10.2337/db07-0381. PMID 17909097.
Zhang L, He H, Balschi JA (July 2007). "Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration". American Journal of Physiology. Heart and Circulatory Physiology. 293 (1): H457-66. doi:10.1152/ajpheart.00002.2007. PMID 17369473.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, et al. (March 2022). "Low-dose metformin targets the lysosomal AMPK pathway through PEN2". Nature. 603 (7899): 159–165. Bibcode:2022Natur.603..159M. doi:10.1038/s41586-022-04431-8. PMC 8891018. PMID 35197629.
Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ (February 2013). "Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP". Nature. 494 (7436): 256–60. Bibcode:2013Natur.494..256M. doi:10.1038/nature11808. PMC 3573218. PMID 23292513.
Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ (July 2006). "Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle". American Journal of Physiology. Endocrinology and Metabolism. 291 (1): E182-9. doi:10.1152/ajpendo.00272.2005. PMID 16478780.
Bailey CJ, Turner RC (February 1996). "Metformin". The New England Journal of Medicine. 334 (9): 574–9. doi:10.1056/NEJM199602293340906. PMID 8569826.
Fantus IG, Brosseau R (October 1986). "Mechanism of action of metformin: insulin receptor and postreceptor effects in vitro and in vivo". The Journal of Clinical Endocrinology and Metabolism. 63 (4): 898–905. doi:10.1210/jcem-63-4-898. PMID 3745404.
Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, et al. (July 2002). "Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes". Diabetes. 51 (7): 2074–2081. doi:10.2337/diabetes.51.7.2074. PMID 12086935.
Hardie DG, Ross FA, Hawley SA (March 2012). "AMPK: a nutrient and energy sensor that maintains energy homeostasis". Nature Reviews. Molecular Cell Biology. 13 (4): 251–262. doi:10.1038/nrm3311. PMC 5726489. PMID 22436748.
LaMoia TE, Shulman GI (January 2021). "Cellular and Molecular Mechanisms of Metformin Action". Endocrine Reviews. 42 (1): 77–96. doi:10.1210/endrev/bnaa023. PMC 7846086. PMID 32897388.
Nikolakis G, Kyrgidis A, Zouboulis CC (August 2019). "Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data". American Journal of Clinical Dermatology. 20 (4): 503–513. doi:10.1007/s40257-019-00442-w. PMID 31073704. S2CID 149443722.
Luque-Ramírez M, Nattero-Chávez L, Ortiz Flores AE, Escobar-Morreale HF (March 2018). "Combined oral contraceptives and/or antiandrogens versus insulin sensitizers for polycystic ovary syndrome: a systematic review and meta-analysis". Human Reproduction Update. 24 (2): 225–241. doi:10.1093/humupd/dmx039. PMID 29293982.
Weersma RK, Zhernakova A, Fu J (August 2020). "Interaction between drugs and the gut microbiome". Gut. 69 (8): 1510–1519. doi:10.1136/gutjnl-2019-320204. PMC 7398478. PMID 32409589.
MacNeil LT, Schertzer JD, Steinberg GR (January 2020). "Bacteria transmit metformin-associated lifespan extension". Nature Reviews. Endocrinology. 16 (1): 9–10. doi:10.1038/s41574-019-0278-3. PMID 31645681. S2CID 204836737.
Jones GR, Molloy MP (June 2020). "Metformin, Microbiome and Protection Against Colorectal Cancer". Digestive Diseases and Sciences. 66 (5): 1409–1414. doi:10.1007/s10620-020-06390-4. PMID 32533543. S2CID 219607625.
Guerrieri D, Moon HY, van Praag H (March 2017). "Exercise in a Pill: The Latest on Exercise-Mimetics". Brain Plasticity. 2 (2): 153–169. doi:10.3233/BPL-160043. PMC 5928571. PMID 29765854.
Boulé NG, Robert C, Bell GJ, Johnson ST, Bell RC, Lewanczuk RZ, et al. (July 2011). "Metformin and exercise in type 2 diabetes: examining treatment modality interactions". Diabetes Care. 34 (7): 1469–1474. doi:10.2337/dc10-2207. PMC 3120188. PMID 21602430.
Rosilio C, Ben-Sahra I, Bost F, Peyron JF (May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia". Cancer Letters. 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID 24462823.
Pryor R, Cabreiro F (November 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". The Biochemical Journal. 471 (3): 307–22. doi:10.1042/bj20150497. PMC 4613459. PMID 26475449.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, et al. (February 2011). "Clinical pharmacokinetics of metformin". Clinical Pharmacokinetics. 50 (2): 81–98. doi:10.2165/11534750-000000000-00000. PMID 21241070. S2CID 1440441.
Robert F, Fendri S, Hary L, Lacroix C, Andréjak M, Lalau JD (June 2003). "Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects". Diabetes & Metabolism. 29 (3): 279–83. doi:10.1016/s1262-3636(07)70037-x. PMID 12909816.
Tilley J, Grimsby J, Erickson S, Berthel S (2010). "Diabetes Drugs: Present and Emerging". Burger's Medicinal Chemistry and Drug Discovery. pp. 1–38. doi:10.1002/0471266949.bmc198. ISBN 978-0-471-26694-5.
Werner E, Bell J (1922). "The preparation of methylguanidine, and of ββ-dimethylguanidine by the interaction of dicyandiamide, and methylammonium and dimethylammonium chlorides respectively". J. Chem. Soc., Trans. 121: 1790–95. doi:10.1039/CT9222101790. Archived from the original on 8 June 2021. Retrieved 4 September 2020.
Shapiro SL, Parrino VA, Freedman L (1959). "Hypoglycemic Agents. I Chemical Properties of β-Phenethylbiguanide. A New Hypoglycemic Agent". J Am Chem Soc. 81 (9): 2220–25. Bibcode:1959JAChS..81.2220S. doi:10.1021/ja01518a052.
Hitchings TJ, Students SP, Shepherd A, Alfredsson M, Saines PJ (2025). "Analysis of a new hydrochloride salt of the common pharmaceutical metformin". CrystEngComm. 27 (48): 7785-7791. Bibcode:2025CEG....27.7785H. doi:10.1039/D5CE00711A.
Witters LA (October 2001). "The blooming of the French lilac". The Journal of Clinical Investigation. 108 (8): 1105–7. doi:10.1172/JCI14178. PMC 209536. PMID 11602616.
See Chemical Abstracts, v.23, 42772 (1929) Slotta KH, Tschesche R (1929). "Über Biguanide, II.: Die blutzucker-senkende Wirkung der Biguanide". Berichte der Deutschen Chemischen Gesellschaft (A and B Series). 62 (6): 1398–1405. doi:10.1002/cber.19290620605.
Campbell IW, ed. (September 2007). "Metformin – life begins at 50: A symposium held on the occasion of the 43rd Annual Meeting of the European Association for the Study of Diabetes, Amsterdam, the Netherlands, September 2007". The British Journal of Diabetes & Vascular Disease. 7 (5): 247–52. doi:10.1177/14746514070070051001.
Dawes GS, Mott JC (March 1950). "Circulatory and respiratory reflexes caused by aromatic guanidines". British Journal of Pharmacology and Chemotherapy. 5 (1): 65–76. doi:10.1111/j.1476-5381.1950.tb00578.x. PMC 1509951. PMID 15405470.
Bailey CJ, Day C (2004). "Metformin: its botanical background". Practical Diabetes International. 21 (3): 115–17. doi:10.1002/pdi.606. S2CID 208203689.
Hadden DR (October 2005). "Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection" (PDF). The Journal of the Royal College of Physicians of Edinburgh. 35 (3): 258–60. doi:10.1177/1478271520053503010. PMID 16402501. Archived (PDF) from the original on 25 October 2020. Retrieved 21 December 2009.
Posselt M, Jaeger A, Schaper JL, Radke M, Benskin JP (December 2018). "Determination of polar organic micropollutants in surface and pore water by high-resolution sampling-direct injection-ultra high performance liquid chromatography-tandem mass spectrometry". Environmental Science: Processes & Impacts. 20 (12): 1716–1727. doi:10.1039/C8EM00390D. PMID 30350841.
Christofides EA (July 2019). "Practical Insights Into Improving Adherence to Metformin Therapy in Patients With Type 2 Diabetes". Clinical Diabetes. 37 (3): 234–241. doi:10.2337/cd18-0063. PMC 6640881. PMID 31371854.
Kaushik D, Karnes RJ, Eisenberg MS, Rangel LJ, Carlson RE, Bergstralh EJ (January 2014). "Effect of metformin on prostate cancer outcomes after radical prostatectomy". Urologic Oncology. 32 (1): 43.e1–7. doi:10.1016/j.urolonc.2013.05.005. PMC 4006350. PMID 23810664.
Bailey CJ, Day C (June 2009). "Fixed-dose single tablet antidiabetic combinations". Diabetes, Obesity & Metabolism. 11 (6): 527–33. doi:10.1111/j.1463-1326.2008.00993.x. PMID 19175373. S2CID 6569131.
Sheehan MT (July 2003). "Current therapeutic options in type 2 diabetes mellitus: a practical approach". Clinical Medicine & Research. 1 (3): 189–200. doi:10.3121/cmr.1.3.189. PMC 1069045. PMID 15931309.
Nissen SE, Wolski K (June 2007). "Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes". The New England Journal of Medicine. 356 (24): 2457–71. doi:10.1056/NEJMoa072761. PMID 17517853.
Grant JS, Graven LJ (September 2016). "Progressing From Metformin to Sulfonylureas or Meglitinides". Workplace Health & Safety. 64 (9): 433–9. doi:10.1177/2165079916644263. PMID 27621259.
Madsen KS, Kähler P, Kähler LK, Madsbad S, Gnesin F, Metzendorf MI, et al. (Cochrane Metabolic and Endocrine Disorders Group) (April 2019). "Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 4 (4) CD012368. doi:10.1002/14651858.CD012368.pub2. PMC 6472662. PMID 30998259.
Dutta S, Shah RB, Singhal S, Dutta SB, Bansal S, Sinha S, et al. (2023). "Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes". Drug Des Devel Ther. 17: 1907–1932. doi:10.2147/DDDT.S409373. PMC 10312383. PMID 37397787.
Froldi G (April 2024). "View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences". Pharmaceuticals. 17 (4): 478. doi:10.3390/ph17040478. PMC 11054066. PMID 38675438.
Soukas AA, Hao H, Wu L (October 2019). "Metformin as Anti-Aging Therapy: Is It for Everyone?". Trends in Endocrinology and Metabolism. 30 (10): 745–755. doi:10.1016/j.tem.2019.07.015. PMC 6779524. PMID 31405774.
Novelle MG, Ali A, Diéguez C, Bernier M, de Cabo R (March 2016). "Metformin: A Hopeful Promise in Aging Research". Cold Spring Harbor Perspectives in Medicine. 6 (3) a025932. doi:10.1101/cshperspect.a025932. PMC 4772077. PMID 26931809.
Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F (May 2010). "Metformin in cancer therapy: a new perspective for an old antidiabetic drug?". Molecular Cancer Therapeutics. 9 (5): 1092–9. doi:10.1158/1535-7163.MCT-09-1186. PMID 20442309.
Malek M, Aghili R, Emami Z, Khamseh ME (September 2013). "Risk of cancer in diabetes: the effect of metformin". ISRN Endocrinology. 2013 636927. doi:10.1155/2013/636927. PMC 3800579. PMID 24224094.
Campbell JM, Bellman SM, Stephenson MD, Lisy K (November 2017). "Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis". Ageing Research Reviews. 40: 31–44. doi:10.1016/j.arr.2017.08.003. PMID 28802803. S2CID 20334490.
Jalali M, Rahimlou M, Mahmoodi M, Moosavian SP, Symonds ME, Jalali R, et al. (September 2020). "The effects of metformin administration on liver enzymes and body composition in non-diabetic patients with non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis: An up-to date systematic review and meta-analysis of randomized controlled trials". Pharmacological Research. 159 104799. doi:10.1016/j.phrs.2020.104799. PMID 32278041. S2CID 215741792.
Blazina I, Selph S (November 2019). "Diabetes drugs for nonalcoholic fatty liver disease: a systematic review". Systematic Reviews. 8 (1) 295. doi:10.1186/s13643-019-1200-8. PMC 6884753. PMID 31783920.
Leoni S, Tovoli F, Napoli L, Serio I, Ferri S, Bolondi L (August 2018). "Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis". World Journal of Gastroenterology. 24 (30): 3361–3373. doi:10.3748/wjg.v24.i30.3361. PMC 6092580. PMID 30122876.
Ibáñez L, Ong K, Valls C, Marcos MV, Dunger DB, de Zegher F (August 2006). "Metformin treatment to prevent early puberty in girls with precocious pubarche". The Journal of Clinical Endocrinology and Metabolism. 91 (8): 2888–91. doi:10.1210/jc.2006-0336. PMID 16684823.
Ibáñez L, López-Bermejo A, Díaz M, Marcos MV, de Zegher F (August 2011). "Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence". The Journal of Clinical Endocrinology and Metabolism. 96 (8): E1262-7. doi:10.1210/jc.2011-0555. PMID 21632811.
Ibáñez L, Díaz R, López-Bermejo A, Marcos MV (March 2009). "Clinical spectrum of premature pubarche: links to metabolic syndrome and ovarian hyperandrogenism". Reviews in Endocrine & Metabolic Disorders. 10 (1): 63–76. doi:10.1007/s11154-008-9096-y. PMID 18726694. S2CID 9129907.
Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, et al. (2022). "Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms". Theranostics. 12 (6): 2722–2740. doi:10.7150/thno.71360. PMC 8965502. PMID 35401820.
Hu D, Xie F, Xiao Y, Lu C, Zhong J, Huang D, et al. (April 2021). "Metformin: A Potential Candidate for Targeting Aging Mechanisms". Aging and Disease. 12 (2): 480–493. doi:10.14336/AD.2020.0702. PMC 7990352. PMID 33815878.
Piskovatska V, Storey KB, Vaiserman AM, Lushchak O (2020). "The Use of Metformin to Increase the Human Healthspan". Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology. Vol. 1260. pp. 319–332. doi:10.1007/978-3-030-42667-5_13. ISBN 978-3-030-42666-8. PMID 32304040.
Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA (June 2016). "Metformin as a Tool to Target Aging". Cell Metabolism. 23 (6): 1060–1065. doi:10.1016/j.cmet.2016.05.011. PMC 5943638. PMID 27304507.
Kulkarni AS, Gubbi S, Barzilai N (July 2020). "Benefits of Metformin in Attenuating the Hallmarks of Aging". Cell Metabolism. 32 (1): 15–30. doi:10.1016/j.cmet.2020.04.001. PMC 7347426. PMID 32333835.
Mohammed I, Hollenberg MD, Ding H, Triggle CR (2021). "A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan". Frontiers in Endocrinology. 12 718942. doi:10.3389/fendo.2021.718942. PMC 8374068. PMID 34421827.
Lee CG, Heckman-Stoddard B, Dabelea D, Gadde KM, Ehrmann D, Ford L, et al. (December 2021). "Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study". Diabetes Care. 44 (12): 2775–2782. doi:10.2337/dc21-1046. PMC 8669534. PMID 34697033.
Zhang J, Wen L, Zhou Q, He K, Teng L (16 September 2020). "Preventative and Therapeutic Effects of Metformin in Gastric Cancer: A New Contribution of an Old Friend". Cancer Management and Research. 12: 8545–8554. doi:10.2147/CMAR.S264032. PMC 7505710. PMID 32982447.
Bramante CT, Boulware DR (March 2026). "Preventing Long COVID With Metformin". Clinical Infectious Diseases. 82 (3) e433–e435. doi:10.1093/cid/ciaf700. PMC 13017490. PMID 41608911.
Li Y, Yang X, Yan P, Sun T, Zeng Z, Li S (2021). "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis". Frontiers in Medicine. 8 704666. doi:10.3389/fmed.2021.704666. PMC 8416892. PMID 34490296.
Ibrahim S, Lowe JR, Bramante CT, Shah S, Klatt NR, Sherwood N, et al. (2021). "Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit". Frontiers in Endocrinology. 12 587801. doi:10.3389/fendo.2021.587801. PMC 8342037. PMID 34367059.
Bramante CT, Ingraham NE, Murray TA, Marmor S, Hovertsen S, Gronski J, et al. (January 2021). "Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis". The Lancet. Healthy Longevity. 2 (1): e34–e41. doi:10.1016/S2666-7568(20)30033-7. PMC 7832552. PMID 33521772.
Gantois I, Popic J, Khoutorsky A, Sonenberg N (January 2019). "Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders". Annual Review of Medicine. 70: 167–181. doi:10.1146/annurev-med-081117-041238. PMID 30365357. S2CID 53093694. Archived from the original on 6 March 2023. Retrieved 9 October 2022.
Campbell JM, Stephenson MD, de Courten B, Chapman I, Bellman SM, Aromataris E (2018). "Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis". Journal of Alzheimer's Disease. 65 (4): 1225–1236. doi:10.3233/jad-180263. PMC 6218120. PMID 30149446.
Campbell JM, Stephenson MD, de Courten B, Chapman I, Bellman SM, Aromataris E (August 2017). "Metformin and Alzheimer's disease, dementia and cognitive impairment: a systematic review protocol". JBI Database of Systematic Reviews and Implementation Reports. 15 (8): 2055–2059. doi:10.11124/JBISRIR-2017-003380. PMID 28800055.
Lam TG, Jeong YS, Kim SA, Ahn SG (March 2018). "New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways". Cancer Science. 109 (3): 699–709. doi:10.1111/cas.13482. PMC 5834796. PMID 29285837.
Tsogbadrakh B, Ju KD, Lee J, Han M, Koh J, Yu Y, et al. (2018). "HL156A, a novel pharmacological agent with potent AMP-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model". PLOS ONE. 13 (8) e0201692. Bibcode:2018PLoSO..1301692T. doi:10.1371/journal.pone.0201692. PMC 6116936. PMID 30161162.
Jeong YS, Lam TG, Jeong S, Ahn SG (August 2020). "Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells". Pharmaceuticals. 13 (9): 218. doi:10.3390/ph13090218. PMC 7560051. PMID 32872293.
Kim SA, Lam TG, Yook JI, Ahn SG (September 2018). "Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice". Aging. 10 (9): 2338–2355. doi:10.18632/aging.101549. PMC 6188477. PMID 30222592.
Choi J, Lee JH, Koh I, Shim JK, Park J, Jeon JY, et al. (October 2016). "Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)". Oncotarget. 7 (40): 65643–65659. doi:10.18632/oncotarget.11595. PMC 5323181. PMID 27582539.
Ju KD, Kim HJ, Tsogbadrakh B, Lee J, Ryu H, Cho EJ, et al. (March 2016). "HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis". American Journal of Physiology. Renal Physiology. 310 (5): F342-50. doi:10.1152/ajprenal.00204.2015. PMID 26661649.

dost.gov.ph (Global: 5,568^th place; English: 3,267^th place)

sntpost.stii.dost.gov.ph

About Eusebio Y. Garcia, see: Carteciano J (2005). "Search for DOST-NRCP Dr. Eusebio Y. Garcia Award". Philippines Department of Science and Technology. Archived from the original on 24 October 2009. Retrieved 5 December 2009.

drugs.com (Global: 529^th place; English: 550^th place)

"Metformin Use During Pregnancy". Drugs.com. 10 September 2019. Archived from the original on 16 April 2020. Retrieved 4 February 2020.
"Metformin Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 24 December 2016. Retrieved 2 January 2017.
"Metformin". Drugs.com. Archived from the original on 28 November 2020. Retrieved 17 July 2020.

europa.eu (Global: 62^nd place; English: 100^th place)

ema.europa.eu

"Metformin and metformin-containing medicines". European Medicines Agency (EMA). 13 October 2016. Archived from the original on 18 November 2023. Retrieved 10 June 2024.
"EMA update on metformin diabetes medicines". European Medicines Agency (EMA). 6 December 2019. Retrieved 11 May 2025.
"EU/3/16/1803 - orphan designation for treatment of progressive myoclonic epilepsy type 2 (Lafora disease)". European Medicines Agency (EMA). 12 December 2016. Archived from the original on 15 September 2024. Retrieved 15 September 2024.
"European Medicines Agency recommends suspension of Avandia, Avandamet and Avaglim" (Press release). European Medicines Agency (EMA). 23 September 2010. Archived from the original on 24 September 2015.
"Glubrava EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 31 March 2020.
"Competact EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 31 March 2020.
"Janumet EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Komboglyze EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 30 October 2020. Retrieved 15 May 2020.
"Vipdomet EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Jentadueto EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 31 March 2020.

ezdrowie.gov.pl (Global: low place; English: low place)

rejestry.ezdrowie.gov.pl

"Glucophage XR - Charakterystyka Produktu Leczniczego". 31 October 2025.

fda.gov (Global: 470^th place; English: 329^th place)

fda.gov

"FDA Drug Safety Communication: FDA revises warnings regarding the use of the diabetes medicine metformin in certain patients with reduced kidney function". U.S. Food and Drug Administration (FDA). 14 November 2017. Archived from the original on 25 May 2021. Retrieved 21 December 2018.
"Statement from Janet Woodcock, M.D., director of FDA's Center for Drug Evaluation and Research, on impurities found in diabetes drugs outside the U.S." U.S. Food and Drug Administration (FDA). 5 December 2019. Archived from the original on 18 January 2021. Retrieved 4 February 2020. This article incorporates text from this source, which is in the public domain.
"Laboratory Tests - Metformin". U.S. Food and Drug Administration (FDA). 3 February 2020. Archived from the original on 25 February 2020. Retrieved 4 February 2020.
"FDA Updates and Press Announcements on NDMA in Metformin". U.S. Food and Drug Administration (FDA). 4 February 2020. Archived from the original on 25 February 2020. Retrieved 4 February 2020.
"FDA Alerts Patients and Health Care Professionals to Nitrosamine Impurity Findings in Certain Metformin Extended-Release Products" (Press release). U.S. Food and Drug Administration (FDA). 28 May 2020. Archived from the original on 22 March 2021. Retrieved 2 June 2020.
"Questions and Answers: NDMA impurities in metformin products". U.S. Food and Drug Administration (FDA). 28 May 2020. Archived from the original on 2 March 2021. Retrieved 5 June 2020.
"Amneal Pharmaceuticals LLC Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended Release Tablets, USP, 500 mg and 750 mg, Due to Detection of N-Nitrosodimethylamine (NDMA) Impurity". U.S. Food and Drug Administration (FDA). 29 May 2020. Archived from the original on 16 January 2021. Retrieved 2 June 2020.
"Apotex Corp. Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets 500mg Due to the Detection of N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 27 May 2020. Archived from the original on 4 March 2021. Retrieved 2 June 2020.
"Teva Pharmaceuticals USA, Inc. Initiates Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets USP 500 mg and 750 mg Due to Detection of N-Nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 2 June 2020. Archived from the original on 21 January 2021. Retrieved 5 June 2020.
"Marksans Pharma Limited Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets, USP 500mg, Due to the Detection of N-Nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 2 June 2020. Archived from the original on 23 January 2021. Retrieved 5 June 2020.
"Laboratory Tests - Metformin". U.S. Food and Drug Administration (FDA). 5 June 2020. Archived from the original on 22 April 2021. Retrieved 5 June 2020. This article incorporates text from this source, which is in the public domain.
"Bayshore Pharmaceuticals, LLC Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets USP, 500 mg and 750 mg Due to the Detection of N-Nitrosodimethylamine (NDMA) Impurity". U.S. Food and Drug Administration (FDA). 19 August 2020. Archived from the original on 19 December 2020. Retrieved 25 August 2020.
"Control of Nitrosamine Impurities in Human Drugs". U.S. Food and Drug Administration. 24 February 2021. Archived from the original on 24 September 2024. Retrieved 6 September 2024.
"FDA Approves New Diabetes Drug" (Press release). U.S. Food and Drug Administration (FDA). 30 December 1994. Archived from the original on 29 September 2007. Retrieved 6 January 2007.
"Questions and Answers about the Seizure of Paxil CR and Avandamet" (Press release). U.S. Food and Drug Administration (FDA). 4 March 2005. Archived from the original on 14 October 2007. Retrieved 27 December 2006.
"Updated Risk Evaluation and Mitigation Strategy (REMS)". U.S. Food and Drug Administration (FDA). 1 July 2021. Archived from the original on 6 March 2023. Retrieved 6 March 2023.
"FDA Drug Safety Communication: FDA requires removal of some prescribing and dispensing restrictions for rosiglitazone-containing diabetes medicines". U.S. Food and Drug Administration (FDA). 21 June 2019. Archived from the original on 4 September 2022. Retrieved 6 March 2023.
"FDA requires removal of certain restrictions on the diabetes drug Avandia". U.S. Food and Drug Administration (FDA) (Press release). 25 November 2013. Archived from the original on 4 May 2015.
"Pioglitazone (marketed as Actos, Actoplus Met, Duetact, and Oseni) Information". U.S. Food and Drug Administration (FDA). 11 January 2017. Archived from the original on 17 January 2021. Retrieved 31 March 2020.
"FDA Drug Safety Communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with reduced kidney function". U.S. Food and Drug Administration (FDA). 3 April 2013. Archived from the original on 25 May 2021. Retrieved 31 March 2020.
"FDA Drug Safety Communication: Updated FDA review concludes that use of type 2 diabetes medicine pioglitazone may be linked to an increased risk of bladder cancer". U.S. Food and Drug Administration (FDA). 4 August 2011. Archived from the original on 26 January 2021. Retrieved 31 March 2020.

accessdata.fda.gov

"Drug Approval Package: Glucophage (metformin)" (PDF). U.S. Food and Drug Administration (FDA). Archived from the original (PDF) on 5 February 2020. Retrieved 8 January 2007.
"Metformin Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 15 September 2024. Retrieved 15 September 2024.
"Metformin Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 8 December 2023. Retrieved 15 September 2024.
"Drug Approval Package: Avandamet (rosiglitazone maleate/metformin HCL) NDA #021410". U.S. Food and Drug Administration (FDA). 30 April 2003. Archived from the original on 10 June 2024. Retrieved 10 June 2024.
"Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 21 March 2021. Retrieved 21 July 2020.
"Linagliptin and Metformin Hydrochloride: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 25 September 2021. Retrieved 24 September 2021.
"Drug Approval Package: PrandiMet (repaglinide/metformin HCI fixed-dose combination) NDA 22386". U.S. Food and Drug Administration (FDA). Archived from the original on 21 July 2020. Retrieved 21 July 2020.
"Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 22 July 2020. Retrieved 21 July 2020.
"Drug Approval Package: Qternmet XR". U.S. Food and Drug Administration (FDA). 27 January 2020. Archived from the original on 17 February 2020. Retrieved 10 June 2024.

figshare.com (Global: 3,822^nd place; English: 2,289^th place)

Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ (July 2006). "Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle". American Journal of Physiology. Endocrinology and Metabolism. 291 (1): E182-9. doi:10.1152/ajpendo.00272.2005. PMID 16478780.

hdl.handle.net (Global: 66^th place; English: 34^th place)

Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. (January 2020). "2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD". European Heart Journal. 41 (2): 255–323. doi:10.1093/eurheartj/ehz486. hdl:2158/1181259. PMID 31497854.
World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
Mead E, Atkinson G, Richter B, Metzendorf MI, Baur L, Finer N, et al. (November 2016). "Drug interventions for the treatment of obesity in children and adolescents". The Cochrane Database of Systematic Reviews. 11 (11) CD012436. doi:10.1002/14651858.CD012436. hdl:10149/620651. PMC 6472619. PMID 27899001.
Tay CT, Joham AE, Hiam DS, Gadalla MA, Pundir J, Thangaratinam S, et al. (November 2018). "Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews". Clinical Endocrinology. 89 (5): 535–553. doi:10.1111/cen.13753. hdl:10536/DRO/DU:30151483. PMID 29846959.
Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, et al. (February 2018). "Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis". Diabetic Medicine. 35 (2): 160–172. doi:10.1111/dme.13523. hdl:10453/130987. PMID 29044702. S2CID 40045912. Archived from the original on 29 April 2023. Retrieved 7 April 2023.

healthycanadians.gc.ca (Global: low place; English: low place)

"Recalls and safety alerts". Health Canada evaluating NDMA in metformin drugs. 5 December 2019. Archived from the original on 17 April 2020. Retrieved 4 February 2020.
"APO-Metformin (2020-02-04)". Health Canada. 4 February 2020. Archived from the original on 27 December 2020. Retrieved 2 June 2020.
"Ranbaxy Metformin Product Recall (2020-02-26)". Health Canada. 26 February 2020. Archived from the original on 26 November 2020. Retrieved 2 June 2020.
"Jamp-Metformin Product Recall (2020-03-10)". Health Canada. 10 March 2020. Archived from the original on 26 November 2020. Retrieved 2 June 2020.

imshealth.com (Global: low place; English: low place)

"The Use of Medicines in the United States: Review of 2010" (PDF). Archived (PDF) from the original on 22 April 2011. (1.79 MB). IMS Institute for Healthcare Informatics (April 2011). Retrieved 28 April 2011.

jamanetwork.com (Global: 3,157^th place; English: 3,607^th place)

Andrès E, Noel E, Goichot B (October 2002). "Metformin-associated vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (19): 2251–2. doi:10.1001/archinte.162.19.2251-a. PMID 12390080. Archived from the original on 10 June 2024. Retrieved 22 January 2024.
Gilligan MA (February 2002). "Metformin and vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (4): 484–5. doi:10.1001/archinte.162.4.484. PMID 11863489. Archived from the original on 1 December 2020. Retrieved 22 January 2024.

jpp.krakow.pl (Global: low place; English: low place)

About Janusz Supniewski, see: Wołkow PP, Korbut R (April 2006). "Pharmacology at the Jagiellonian University in Kracow, short review of contribution to global science and cardiovascular research through 400 years of history" (PDF). Journal of Physiology and Pharmacology. 57 (Suppl 1): 119–136. PMID 16766803. Archived from the original (PDF) on 24 October 2009. Retrieved 22 December 2009.

mcgill.ca (Global: 2,445^th place; English: 1,513^th place)

escholarship.mcgill.ca

Gantois I, Popic J, Khoutorsky A, Sonenberg N (January 2019). "Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders". Annual Review of Medicine. 70: 167–181. doi:10.1146/annurev-med-081117-041238. PMID 30365357. S2CID 53093694. Archived from the original on 6 March 2023. Retrieved 9 October 2022.

medicines.org.uk (Global: 4,892^nd place; English: 3,451^st place)

"Glucophage 500 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 25 October 2022. Archived from the original on 20 June 2022. Retrieved 5 March 2023.

modernmedicine.com (Global: low place; English: low place)

drugtopics.modernmedicine.com

"2009 Top 200 branded drugs by total prescriptions" (PDF). Archived from the original (PDF) on 14 July 2011. (96.5 KB). Drug Topics (17 June 2010). Retrieved 2 September 2010.

nature.com (Global: 207^th place; English: 347^th place)

blogs.nature.com

"US agency reverses stance on controversial diabetes drug". Archived from the original on 11 December 2015.

nhs.uk (Global: 2,637^th place; English: 2,254^th place)

"Metformin: medicine to treat type 2 diabetes". National Health Service. 25 February 2019. Archived from the original on 11 March 2021. Retrieved 15 October 2020.
"Vitamin B12 or folate deficiency anaemia - Symptoms". nhs.uk. 20 October 2017. Archived from the original on 22 November 2024. Retrieved 28 November 2024.

nice.org.uk (Global: 4,081^st place; English: 3,905^th place)

nice.org.uk

National Collaborating Centre for Women's and Children's Health (2004). Fertility: assessment and treatment for people with fertility problems (PDF). London: Royal College of Obstetricians and Gynaecologists. pp. 58–59. ISBN 978-1-900364-97-3. Archived (PDF) from the original on 11 July 2009.

bnf.nice.org.uk

"METFORMIN HYDROCHLORIDE". NICE. Archived from the original on 10 June 2021. Retrieved 15 October 2020.

nih.gov (Global: 5^th place; English: 5^th place)

pubmed.ncbi.nlm.nih.gov

Sirtori CR, Franceschini G, Galli-Kienle M, Cighetti G, Galli G, Bondioli A, et al. (December 1978). "Disposition of metformin (N,N-dimethylbiguanide) in man". Clinical Pharmacology and Therapeutics. 24 (6): 683–93. doi:10.1002/cpt1978246683. PMID 710026. S2CID 24531910.
Lucis OJ (January 1983). "The status of metformin in Canada". Canadian Medical Association Journal. 128 (1): 24–6. PMC 1874707. PMID 6847752.
Dunn CJ, Peters DH (May 1995). "Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus". Drugs. 49 (5): 721–49. doi:10.2165/00003495-199549050-00007. PMID 7601013.
Hundal RS, Inzucchi SE (2003). "Metformin: new understandings, new uses". Drugs. 63 (18): 1879–94. doi:10.2165/00003495-200363180-00001. PMID 12930161.
Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, Freeman R, et al. (January 2022). "9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022". Diabetes Care. 45 (Suppl 1): S125–S143. doi:10.2337/dc22-s009. PMID 34964831. S2CID 245538347.
Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. (January 2020). "2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD". European Heart Journal. 41 (2): 255–323. doi:10.1093/eurheartj/ehz486. hdl:2158/1181259. PMID 31497854.
Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z, et al. (June 2016). "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis". Annals of Internal Medicine. 164 (11): 740–751. doi:10.7326/M15-2650. PMID 27088241. S2CID 32016657.
de Silva VA, Suraweera C, Ratnatunga SS, Dayabandara M, Wanniarachchi N, Hanwella R (October 2016). "Metformin in prevention and treatment of antipsychotic-induced weight gain: a systematic review and meta-analysis". BMC Psychiatry. 16 (1) 341. doi:10.1186/s12888-016-1049-5. PMC 5048618. PMID 27716110.
Lin H, Ao H, Guo G, Liu M (2023). "The Role and Mechanism of Metformin in Inflammatory Diseases". Journal of Inflammation Research. 16: 5545–5564. doi:10.2147/JIR.S436147. PMC 10680465. PMID 38026260.
Saisho Y (March 2015). "Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect". Endocrine, Metabolic & Immune Disorders Drug Targets. 15 (3): 196–205. doi:10.2174/1871530315666150316124019. PMID 25772174.
"Type 2 diabetes and metformin. First choice for monotherapy: weak evidence of efficacy but well-known and acceptable adverse effects". Prescrire International. 23 (154): 269–272. November 2014. PMID 25954799.
Triggle CR, Ding H (January 2017). "Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium". Acta Physiologica. 219 (1): 138–151. doi:10.1111/apha.12644. PMID 26680745. S2CID 312517.
Blumenberg A, Benabbas R, Sinert R, Jeng A, Wiener SW (April 2020). "Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA". Journal of Medical Toxicology. 16 (2): 222–229. doi:10.1007/s13181-019-00755-6. PMC 7099117. PMID 31907741.
Lipska KJ, Bailey CJ, Inzucchi SE (June 2011). "Use of metformin in the setting of mild-to-moderate renal insufficiency". Diabetes Care. 34 (6): 1431–7. doi:10.2337/dc10-2361. PMC 3114336. PMID 21617112.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, et al. (February 2020). "GDF15 mediates the effects of metformin on body weight and energy balance". Nature. 578 (7795): 444–448. Bibcode:2020Natur.578..444C. doi:10.1038/s41586-019-1911-y. PMC 7234839. PMID 31875646.
Day EA, Ford RJ, Smith BK, Mohammadi-Shemirani P, Morrow MR, Gutgesell RM, et al. (December 2019). "Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss". Nature Metabolism. 1 (12): 1202–1208. doi:10.1038/s42255-019-0146-4. PMID 32694673. S2CID 213199603.
Pappachan JM, Viswanath AK (January 2017). "Medical Management of Diabesity: Do We Have Realistic Targets?". Current Diabetes Reports. 17 (1) 4. doi:10.1007/s11892-017-0828-9. PMID 28101792. S2CID 10289148.
LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, et al. (March 2022). "Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis". Proceedings of the National Academy of Sciences of the United States of America. 119 (10) e2122287119. Bibcode:2022PNAS..11922287L. doi:10.1073/pnas.2122287119. PMC 8916010. PMID 35238637.
Lord JM, Flight IH, Norman RJ (October 2003). "Metformin in polycystic ovary syndrome: systematic review and meta-analysis". BMJ. 327 (7421): 951–3. doi:10.1136/bmj.327.7421.951. PMC 259161. PMID 14576245.
Bennett WL, Maruthur NM, Singh S, Segal JB, Wilson LM, Chatterjee R, et al. (May 2011). "Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations". Annals of Internal Medicine. 154 (9): 602–13. doi:10.7326/0003-4819-154-9-201105030-00336. PMC 3733115. PMID 21403054.
Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. (June 2012). "Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)". Diabetes Care. 35 (6): 1364–79. doi:10.2337/dc12-0413. PMC 3357214. PMID 22517736.
Qaseem A, Humphrey LL, Sweet DE, Starkey M, Shekelle P (February 2012). "Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians". Annals of Internal Medicine. 156 (3): 218–31. doi:10.7326/0003-4819-156-3-201202070-00011. PMID 22312141.
Jia Y, Lao Y, Zhu H, Li N, Leung SW (January 2019). "Is metformin still the most efficacious first-line oral hypoglycaemic drug in treating type 2 diabetes? A network meta-analysis of randomized controlled trials". Obesity Reviews. 20 (1): 1–12. doi:10.1111/obr.12753. PMID 30230172.
Golay A (January 2008). "Metformin and body weight". International Journal of Obesity. 32 (1): 61–72. doi:10.1038/sj.ijo.0803695. PMID 17653063.
Mead E, Atkinson G, Richter B, Metzendorf MI, Baur L, Finer N, et al. (November 2016). "Drug interventions for the treatment of obesity in children and adolescents". The Cochrane Database of Systematic Reviews. 11 (11) CD012436. doi:10.1002/14651858.CD012436. hdl:10149/620651. PMC 6472619. PMID 27899001.
Bolen S, Feldman L, Vassy J, Wilson L, Yeh HC, Marinopoulos S, et al. (September 2007). "Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus". Annals of Internal Medicine. 147 (6): 386–399. doi:10.7326/0003-4819-147-6-200709180-00178. PMID 17638715.
Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B, et al. (Cochrane Metabolic and Endocrine Disorders Group) (December 2019). "Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 2019 (12) CD008558. doi:10.1002/14651858.CD008558.pub2. PMC 6889926. PMID 31794067.
Morley LC, Tang T, Yasmin E, Norman RJ, Balen AH (November 2017). "Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility". The Cochrane Database of Systematic Reviews. 11 (2) CD003053. doi:10.1002/14651858.CD003053.pub6. PMC 6486196. PMID 29183107. Our updated review suggests that metformin alone may be beneficial over a placebo for live birth, although the evidence quality was low.
Ghazeeri GS, Nassar AH, Younes Z, Awwad JT (June 2012). "Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview". Acta Obstetricia et Gynecologica Scandinavica. 91 (6): 658–78. doi:10.1111/j.1600-0412.2012.01385.x. PMID 22375613. S2CID 41145972.
Kumar P, Khan K (May 2012). "Effects of metformin use in pregnant patients with polycystic ovary syndrome". Journal of Human Reproductive Sciences. 5 (2): 166–9. doi:10.4103/0974-1208.101012. PMC 3493830. PMID 23162354.
Tay CT, Joham AE, Hiam DS, Gadalla MA, Pundir J, Thangaratinam S, et al. (November 2018). "Pharmacological and surgical treatment of nonreproductive outcomes in polycystic ovary syndrome: An overview of systematic reviews". Clinical Endocrinology. 89 (5): 535–553. doi:10.1111/cen.13753. hdl:10536/DRO/DU:30151483. PMID 29846959.
Tso LO, Costello MF, Albuquerque LE, Andriolo RB, Macedo CR (December 2020). "Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome". The Cochrane Database of Systematic Reviews. 2020 (12) CD006105. doi:10.1002/14651858.CD006105.pub4. PMC 8171384. PMID 33347618.
Dodd JM, Grivell RM, Deussen AR, Hague WM (July 2018). "Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes". The Cochrane Database of Systematic Reviews. 2018 (7) CD010564. doi:10.1002/14651858.CD010564.pub2. PMC 6513233. PMID 30039871.
The Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (March 2008). "Consensus on infertility treatment related to polycystic ovary syndrome". Human Reproduction. 23 (3): 462–77. doi:10.1093/humrep/dem426. PMID 18308833.
Diamanti-Kandarakis E, Economou F, Palimeri S, Christakou C (September 2010). "Metformin in polycystic ovary syndrome". Annals of the New York Academy of Sciences. 1205 (1): 192–8. Bibcode:2010NYASA1205..192D. doi:10.1111/j.1749-6632.2010.05679.x. PMID 20840272. S2CID 44203632.
Diamanti-Kandarakis E, Christakou CD, Kandaraki E, Economou FN (February 2010). "Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome". European Journal of Endocrinology. 162 (2): 193–212. doi:10.1530/EJE-09-0733. PMID 19841045.
Butalia S, Gutierrez L, Lodha A, Aitken E, Zakariasen A, Donovan L (January 2017). "Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis". Diabetic Medicine. 34 (1): 27–36. doi:10.1111/dme.13150. PMID 27150509. S2CID 3418227.
Nicholson W, Bolen S, Witkop CT, Neale D, Wilson L, Bass E (January 2009). "Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review". Obstetrics and Gynecology. 113 (1): 193–205. doi:10.1097/AOG.0b013e318190a459. PMID 19104375. S2CID 28115952.
Kitwitee P, Limwattananon S, Limwattananon C, Waleekachonlert O, Ratanachotpanich T, Phimphilai M, et al. (September 2015). "Metformin for the treatment of gestational diabetes: An updated meta-analysis". Diabetes Research and Clinical Practice. 109 (3): 521–32. doi:10.1016/j.diabres.2015.05.017. PMID 26117686.
Balsells M, García-Patterson A, Solà I, Roqué M, Gich I, Corcoy R (January 2015). "Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis". BMJ (Systematic Review & Meta-Analysis). 350: h102. doi:10.1136/bmj.h102. PMC 4301599. PMID 25609400.
Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, et al. (February 2018). "Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis". Diabetic Medicine. 35 (2): 160–172. doi:10.1111/dme.13523. hdl:10453/130987. PMID 29044702. S2CID 40045912. Archived from the original on 29 April 2023. Retrieved 7 April 2023.
Sivalingam VN, Myers J, Nicholas S, Balen AH, Crosbie EJ (2014). "Metformin in reproductive health, pregnancy and gynaecological cancer: established and emerging indications". Human Reproduction Update. 20 (6): 853–68. doi:10.1093/humupd/dmu037. PMID 25013215.
Tarry-Adkins JL, Aiken CE, Ozanne SE (August 2019). "Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis". PLOS Medicine. 16 (8) e1002848. doi:10.1371/journal.pmed.1002848. PMC 6684046. PMID 31386659.
Dutta D, Sharma M, Nagendra L, Bhattacharya S, Mohindra R, Yajnik CS (September 2024). "Long-Term Impact on Offspring (5 to 11 Years of Age) of Metformin Use in Pregnancy in Mothers With Diabetes: A Systematic Review and Meta-Analysis". Endocrine Practice. 30 (9): 854–862. doi:10.1016/j.eprac.2024.05.017. PMID 38876183.
Yerevanian A, Soukas AA (June 2019). "Metformin: Mechanisms in Human Obesity and Weight Loss". Current Obesity Reports. 8 (2): 156–164. doi:10.1007/s13679-019-00335-3. PMC 6520185. PMID 30874963.
Choi YJ (2015). "Efficacy of adjunctive treatments added to olanzapine or clozapine for weight control in patients with schizophrenia: a systematic review and meta-analysis". TheScientificWorldJournal. 2015 970730. doi:10.1155/2015/970730. PMC 4310265. PMID 25664341.
Praharaj SK, Jana AK, Goyal N, Sinha VK (March 2011). "Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis". British Journal of Clinical Pharmacology. 71 (3): 377–82. doi:10.1111/j.1365-2125.2010.03783.x. PMC 3045546. PMID 21284696.
Yu O, Lu M, Lai TK, Hahn M, Agarwal SM, O'Donoghue B, et al. (2024). "Metformin co-commencement at time of antipsychotic initiation for attenuation of weight gain: a systematic review and meta-analysis". Therapeutic Advances in Psychopharmacology. 14 20451253241255476. doi:10.1177/20451253241255476. PMC 11141220. PMID 38827016.
Siskind DJ, Leung J, Russell AW, Wysoczanski D, Kisely S (2016). "Metformin for Clozapine Associated Obesity: A Systematic Review and Meta-Analysis". PLOS ONE. 11 (6) e0156208. Bibcode:2016PLoSO..1156208S. doi:10.1371/journal.pone.0156208. PMC 4909277. PMID 27304831.
Vella S, Buetow L, Royle P, Livingstone S, Colhoun HM, Petrie JR (May 2010). "The use of metformin in type 1 diabetes: a systematic review of efficacy". Diabetologia. 53 (5): 809–20. doi:10.1007/s00125-009-1636-9. PMID 20057994.
Mohamed S (October 2024). "Metformin: Diverse molecular mechanisms, gastrointestinal effects and overcoming intolerance in type 2 Diabetes Mellitus: A review". Medicine. 103 (43) e40221. doi:10.1097/MD.0000000000040221. PMC 11521032. PMID 39470509.
Khurana R, Malik IS (January 2010). "Metformin: safety in cardiac patients". Heart. 96 (2): 99–102. doi:10.1136/hrt.2009.173773. PMID 19564648. S2CID 9746741.
Ahmad R, Haque M (October 2024). "Metformin: Beyond Type 2 Diabetes Mellitus". Cureus. 16 (10) e71730. doi:10.7759/cureus.71730. PMC 11486535. PMID 39421288.
Heaf J (June 2014). "Metformin in chronic kidney disease: time for a rethink". Peritoneal Dialysis International. 34 (4): 353–357. doi:10.3747/pdi.2013.00344. PMC 4079480. PMID 24711640.
Nabrdalik K, Hendel M, Irlik K, Kwiendacz H, Łoniewski I, Bucci T, et al. (September 2024). "Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies". BMC Endocrine Disorders. 24 (1) 206. doi:10.1186/s12902-024-01727-w. PMC 11440709. PMID 39350158.
Fujita Y, Inagaki N (January 2017). "Metformin: New Preparations and Nonglycemic Benefits". Current Diabetes Reports. 17 (1) 5. doi:10.1007/s11892-017-0829-8. PMID 28116648. S2CID 9277684.
Wulffelé MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, et al. (November 2003). "Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial". Journal of Internal Medicine. 254 (5): 455–63. doi:10.1046/j.1365-2796.2003.01213.x. PMID 14535967. S2CID 12507226.
Andrès E, Noel E, Goichot B (October 2002). "Metformin-associated vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (19): 2251–2. doi:10.1001/archinte.162.19.2251-a. PMID 12390080. Archived from the original on 10 June 2024. Retrieved 22 January 2024.
Gilligan MA (February 2002). "Metformin and vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (4): 484–5. doi:10.1001/archinte.162.4.484. PMID 11863489. Archived from the original on 1 December 2020. Retrieved 22 January 2024.
de Jager J, Kooy A, Lehert P, Wulffelé MG, van der Kolk J, Bets D, et al. (May 2010). "Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial". BMJ. 340 c2181. doi:10.1136/bmj.c2181. PMC 2874129. PMID 20488910.
Ting RZ, Szeto CC, Chan MH, Ma KK, Chow KM (October 2006). "Risk factors of vitamin B(12) deficiency in patients receiving metformin". Archives of Internal Medicine. 166 (18): 1975–9. doi:10.1001/archinte.166.18.1975. PMID 17030830.
Ramzan NU, Shahjahan K, Dhillon RA, Khan NT, Hashmat MB, Anwer MU, et al. (September 2024). "Vitamin B12 Deficiency in Patients Taking Metformin: Pathogenesis and Recommendations". Cureus. 16 (9) e68550. doi:10.7759/cureus.68550. PMC 11374140. PMID 39233729.
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK (2014). "Metformin in patients with type 2 diabetes and kidney disease: a systematic review". JAMA. 312 (24): 2668–75. doi:10.1001/jama.2014.15298. PMC 4427053. PMID 25536258.
Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. (January 2009). "Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes". Diabetologia. 52 (1): 17–30. doi:10.1007/s00125-008-1157-y. PMID 18941734.
Stang M, Wysowski DK, Butler-Jones D (June 1999). "Incidence of lactic acidosis in metformin users". Diabetes Care. 22 (6): 925–7. doi:10.2337/diacare.22.6.925. PMID 10372243.
Salpeter SR, Greyber E, Pasternak GA, Salpeter EE (November 2003). "Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis". Archives of Internal Medicine. 163 (21): 2594–602. doi:10.1001/archinte.163.21.2594. PMID 14638559.
Kirpichnikov D, McFarlane SI, Sowers JR (July 2002). "Metformin: an update". Annals of Internal Medicine. 137 (1): 25–33. doi:10.7326/0003-4819-137-1-200207020-00009. PMID 12093242. S2CID 9140541.
Forrester MB (July 2008). "Adult metformin ingestions reported to Texas poison control centers, 2000-2006". Human & Experimental Toxicology. 27 (7): 575–83. Bibcode:2008HETox..27..575F. doi:10.1177/0960327108090589. PMID 18829734. S2CID 5413561.
Suchard JR, Grotsky TA (August 2008). "Fatal metformin overdose presenting with progressive hyperglycemia". The Western Journal of Emergency Medicine. 9 (3): 160–4. PMC 2672258. PMID 19561734.
Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, et al. (August 2015). "Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup". Critical Care Medicine. 43 (8): 1716–30. doi:10.1097/CCM.0000000000001002. PMID 25860205. S2CID 13861731.
Liu A, Coleman SP (November 2009). "Determination of metformin in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877 (29): 3695–700. doi:10.1016/j.jchromb.2009.09.020. PMID 19783231.
Teale KF, Devine A, Stewart H, Harper NJ (July 1998). "The management of metformin overdose". Anaesthesia. 53 (7): 698–701. doi:10.1046/j.1365-2044.1998.436-az0549.x. PMID 9771180. S2CID 45218798.
Somogyi A, Stockley C, Keal J, Rolan P, Bochner F (May 1987). "Reduction of metformin renal tubular secretion by cimetidine in man". British Journal of Clinical Pharmacology. 23 (5): 545–51. doi:10.1111/j.1365-2125.1987.tb03090.x. PMC 1386190. PMID 3593625.
Jayasagar G, Krishna Kumar M, Chandrasekhar K, Madhusudan Rao C, Madhusudan Rao Y (2002). "Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers". Drug Metabolism and Drug Interactions. 19 (1): 41–8. doi:10.1515/dmdi.2002.19.1.41. PMID 12222753. S2CID 26919498.
May M, Schindler C (April 2016). "Clinically and pharmacologically relevant interactions of antidiabetic drugs". Therapeutic Advances in Endocrinology and Metabolism. 7 (2): 69–83. doi:10.1177/2042018816638050. PMC 4821002. PMID 27092232.
Rena G, Pearson ER, Sakamoto K (September 2013). "Molecular mechanism of action of metformin: old or new insights?". Diabetologia. 56 (9): 1898–906. doi:10.1007/s00125-013-2991-0. PMC 3737434. PMID 23835523.
Burcelin R (May 2014). "The antidiabetic gutsy role of metformin uncovered?". Gut. 63 (5): 706–7. doi:10.1136/gutjnl-2013-305370. PMID 23840042. S2CID 42142919.
Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, et al. (June 2014). "Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase". Nature. 510 (7506): 542–6. Bibcode:2014Natur.510..542M. doi:10.1038/nature13270. PMC 4074244. PMID 24847880.
Vázquez-Borrego MC, Fuentes-Fayos AC, Gahete MD, Castaño JP, Kineman RD, Luque RM (2018). "The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions". Cellular Physiology and Biochemistry. 49 (4): 1444–1459. doi:10.1159/000493448. PMID 30205369.
Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, et al. (December 2000). "Mechanism by which metformin reduces glucose production in type 2 diabetes". Diabetes. 49 (12): 2063–9. doi:10.2337/diabetes.49.12.2063. PMC 2995498. PMID 11118008.
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. (October 2001). "Role of AMP-activated protein kinase in mechanism of metformin action". The Journal of Clinical Investigation. 108 (8): 1167–74. doi:10.1172/JCI13505. PMC 209533. PMID 11602624.
Towler MC, Hardie DG (February 2007). "AMP-activated protein kinase in metabolic control and insulin signaling". Circulation Research. 100 (3): 328–41. doi:10.1161/01.RES.0000256090.42690.05. PMID 17307971.
Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, et al. (February 2008). "Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP". Diabetes. 57 (2): 306–14. doi:10.2337/db07-0381. PMID 17909097.
Zhang L, He H, Balschi JA (July 2007). "Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration". American Journal of Physiology. Heart and Circulatory Physiology. 293 (1): H457-66. doi:10.1152/ajpheart.00002.2007. PMID 17369473.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, et al. (March 2022). "Low-dose metformin targets the lysosomal AMPK pathway through PEN2". Nature. 603 (7899): 159–165. Bibcode:2022Natur.603..159M. doi:10.1038/s41586-022-04431-8. PMC 8891018. PMID 35197629.
Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ (February 2013). "Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP". Nature. 494 (7436): 256–60. Bibcode:2013Natur.494..256M. doi:10.1038/nature11808. PMC 3573218. PMID 23292513.
Collier CA, Bruce CR, Smith AC, Lopaschuk G, Dyck DJ (July 2006). "Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle". American Journal of Physiology. Endocrinology and Metabolism. 291 (1): E182-9. doi:10.1152/ajpendo.00272.2005. PMID 16478780.
Bailey CJ, Turner RC (February 1996). "Metformin". The New England Journal of Medicine. 334 (9): 574–9. doi:10.1056/NEJM199602293340906. PMID 8569826.
Fantus IG, Brosseau R (October 1986). "Mechanism of action of metformin: insulin receptor and postreceptor effects in vitro and in vivo". The Journal of Clinical Endocrinology and Metabolism. 63 (4): 898–905. doi:10.1210/jcem-63-4-898. PMID 3745404.
Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, et al. (July 2002). "Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes". Diabetes. 51 (7): 2074–2081. doi:10.2337/diabetes.51.7.2074. PMID 12086935.
Hardie DG, Ross FA, Hawley SA (March 2012). "AMPK: a nutrient and energy sensor that maintains energy homeostasis". Nature Reviews. Molecular Cell Biology. 13 (4): 251–262. doi:10.1038/nrm3311. PMC 5726489. PMID 22436748.
LaMoia TE, Shulman GI (January 2021). "Cellular and Molecular Mechanisms of Metformin Action". Endocrine Reviews. 42 (1): 77–96. doi:10.1210/endrev/bnaa023. PMC 7846086. PMID 32897388.
Nikolakis G, Kyrgidis A, Zouboulis CC (August 2019). "Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data". American Journal of Clinical Dermatology. 20 (4): 503–513. doi:10.1007/s40257-019-00442-w. PMID 31073704. S2CID 149443722.
Luque-Ramírez M, Nattero-Chávez L, Ortiz Flores AE, Escobar-Morreale HF (March 2018). "Combined oral contraceptives and/or antiandrogens versus insulin sensitizers for polycystic ovary syndrome: a systematic review and meta-analysis". Human Reproduction Update. 24 (2): 225–241. doi:10.1093/humupd/dmx039. PMID 29293982.
Weersma RK, Zhernakova A, Fu J (August 2020). "Interaction between drugs and the gut microbiome". Gut. 69 (8): 1510–1519. doi:10.1136/gutjnl-2019-320204. PMC 7398478. PMID 32409589.
MacNeil LT, Schertzer JD, Steinberg GR (January 2020). "Bacteria transmit metformin-associated lifespan extension". Nature Reviews. Endocrinology. 16 (1): 9–10. doi:10.1038/s41574-019-0278-3. PMID 31645681. S2CID 204836737.
Jones GR, Molloy MP (June 2020). "Metformin, Microbiome and Protection Against Colorectal Cancer". Digestive Diseases and Sciences. 66 (5): 1409–1414. doi:10.1007/s10620-020-06390-4. PMID 32533543. S2CID 219607625.
Guerrieri D, Moon HY, van Praag H (March 2017). "Exercise in a Pill: The Latest on Exercise-Mimetics". Brain Plasticity. 2 (2): 153–169. doi:10.3233/BPL-160043. PMC 5928571. PMID 29765854.
Boulé NG, Robert C, Bell GJ, Johnson ST, Bell RC, Lewanczuk RZ, et al. (July 2011). "Metformin and exercise in type 2 diabetes: examining treatment modality interactions". Diabetes Care. 34 (7): 1469–1474. doi:10.2337/dc10-2207. PMC 3120188. PMID 21602430.
Rosilio C, Ben-Sahra I, Bost F, Peyron JF (May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia". Cancer Letters. 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID 24462823.
Pryor R, Cabreiro F (November 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". The Biochemical Journal. 471 (3): 307–22. doi:10.1042/bj20150497. PMC 4613459. PMID 26475449.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, et al. (February 2011). "Clinical pharmacokinetics of metformin". Clinical Pharmacokinetics. 50 (2): 81–98. doi:10.2165/11534750-000000000-00000. PMID 21241070. S2CID 1440441.
Robert F, Fendri S, Hary L, Lacroix C, Andréjak M, Lalau JD (June 2003). "Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects". Diabetes & Metabolism. 29 (3): 279–83. doi:10.1016/s1262-3636(07)70037-x. PMID 12909816.
Witters LA (October 2001). "The blooming of the French lilac". The Journal of Clinical Investigation. 108 (8): 1105–7. doi:10.1172/JCI14178. PMC 209536. PMID 11602616.
Dawes GS, Mott JC (March 1950). "Circulatory and respiratory reflexes caused by aromatic guanidines". British Journal of Pharmacology and Chemotherapy. 5 (1): 65–76. doi:10.1111/j.1476-5381.1950.tb00578.x. PMC 1509951. PMID 15405470.
Quoted from Chemical Abstracts, v.45, 24828 (1951) Garcia EY (July 1950). "Flumamine, a new synthetic analgesic and anti-flu drug". Journal of the Philippine Medical Association. 26 (7): 287–93. PMID 14779282.
About Janusz Supniewski, see: Wołkow PP, Korbut R (April 2006). "Pharmacology at the Jagiellonian University in Kracow, short review of contribution to global science and cardiovascular research through 400 years of history" (PDF). Journal of Physiology and Pharmacology. 57 (Suppl 1): 119–136. PMID 16766803. Archived from the original (PDF) on 24 October 2009. Retrieved 22 December 2009.
See Chemical Abstracts, v. 52, 22272 (1958) Supniewski J, Chrusciel T (1954). "[N-dimethyl-di-guanide and its biological properties]". Archivum Immunologiae et Therapiae Experimentalis (in Polish). 2: 1–15. PMID 13269290.
Hadden DR (October 2005). "Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection" (PDF). The Journal of the Royal College of Physicians of Edinburgh. 35 (3): 258–60. doi:10.1177/1478271520053503010. PMID 16402501. Archived (PDF) from the original on 25 October 2020. Retrieved 21 December 2009.
Posselt M, Jaeger A, Schaper JL, Radke M, Benskin JP (December 2018). "Determination of polar organic micropollutants in surface and pore water by high-resolution sampling-direct injection-ultra high performance liquid chromatography-tandem mass spectrometry". Environmental Science: Processes & Impacts. 20 (12): 1716–1727. doi:10.1039/C8EM00390D. PMID 30350841.
Christofides EA (July 2019). "Practical Insights Into Improving Adherence to Metformin Therapy in Patients With Type 2 Diabetes". Clinical Diabetes. 37 (3): 234–241. doi:10.2337/cd18-0063. PMC 6640881. PMID 31371854.
Kaushik D, Karnes RJ, Eisenberg MS, Rangel LJ, Carlson RE, Bergstralh EJ (January 2014). "Effect of metformin on prostate cancer outcomes after radical prostatectomy". Urologic Oncology. 32 (1): 43.e1–7. doi:10.1016/j.urolonc.2013.05.005. PMC 4006350. PMID 23810664.
Bailey CJ, Day C (June 2009). "Fixed-dose single tablet antidiabetic combinations". Diabetes, Obesity & Metabolism. 11 (6): 527–33. doi:10.1111/j.1463-1326.2008.00993.x. PMID 19175373. S2CID 6569131.
Sheehan MT (July 2003). "Current therapeutic options in type 2 diabetes mellitus: a practical approach". Clinical Medicine & Research. 1 (3): 189–200. doi:10.3121/cmr.1.3.189. PMC 1069045. PMID 15931309.
Nissen SE, Wolski K (June 2007). "Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes". The New England Journal of Medicine. 356 (24): 2457–71. doi:10.1056/NEJMoa072761. PMID 17517853.
Grant JS, Graven LJ (September 2016). "Progressing From Metformin to Sulfonylureas or Meglitinides". Workplace Health & Safety. 64 (9): 433–9. doi:10.1177/2165079916644263. PMID 27621259.
Madsen KS, Kähler P, Kähler LK, Madsbad S, Gnesin F, Metzendorf MI, et al. (Cochrane Metabolic and Endocrine Disorders Group) (April 2019). "Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 4 (4) CD012368. doi:10.1002/14651858.CD012368.pub2. PMC 6472662. PMID 30998259.
Panikar V, Chandalia HB, Joshi SR, Fafadia A, Santvana C (November 2003). "Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy". The Journal of the Association of Physicians of India. 51: 1061–4. PMID 15260389. S2CID 22085315.
Dutta S, Shah RB, Singhal S, Dutta SB, Bansal S, Sinha S, et al. (2023). "Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes". Drug Des Devel Ther. 17: 1907–1932. doi:10.2147/DDDT.S409373. PMC 10312383. PMID 37397787.
Froldi G (April 2024). "View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences". Pharmaceuticals. 17 (4): 478. doi:10.3390/ph17040478. PMC 11054066. PMID 38675438.
Soukas AA, Hao H, Wu L (October 2019). "Metformin as Anti-Aging Therapy: Is It for Everyone?". Trends in Endocrinology and Metabolism. 30 (10): 745–755. doi:10.1016/j.tem.2019.07.015. PMC 6779524. PMID 31405774.
Novelle MG, Ali A, Diéguez C, Bernier M, de Cabo R (March 2016). "Metformin: A Hopeful Promise in Aging Research". Cold Spring Harbor Perspectives in Medicine. 6 (3) a025932. doi:10.1101/cshperspect.a025932. PMC 4772077. PMID 26931809.
Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F (May 2010). "Metformin in cancer therapy: a new perspective for an old antidiabetic drug?". Molecular Cancer Therapeutics. 9 (5): 1092–9. doi:10.1158/1535-7163.MCT-09-1186. PMID 20442309.
Malek M, Aghili R, Emami Z, Khamseh ME (September 2013). "Risk of cancer in diabetes: the effect of metformin". ISRN Endocrinology. 2013 636927. doi:10.1155/2013/636927. PMC 3800579. PMID 24224094.
Campbell JM, Bellman SM, Stephenson MD, Lisy K (November 2017). "Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis". Ageing Research Reviews. 40: 31–44. doi:10.1016/j.arr.2017.08.003. PMID 28802803. S2CID 20334490.
Jalali M, Rahimlou M, Mahmoodi M, Moosavian SP, Symonds ME, Jalali R, et al. (September 2020). "The effects of metformin administration on liver enzymes and body composition in non-diabetic patients with non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis: An up-to date systematic review and meta-analysis of randomized controlled trials". Pharmacological Research. 159 104799. doi:10.1016/j.phrs.2020.104799. PMID 32278041. S2CID 215741792.
Blazina I, Selph S (November 2019). "Diabetes drugs for nonalcoholic fatty liver disease: a systematic review". Systematic Reviews. 8 (1) 295. doi:10.1186/s13643-019-1200-8. PMC 6884753. PMID 31783920.
Leoni S, Tovoli F, Napoli L, Serio I, Ferri S, Bolondi L (August 2018). "Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis". World Journal of Gastroenterology. 24 (30): 3361–3373. doi:10.3748/wjg.v24.i30.3361. PMC 6092580. PMID 30122876.
Ibáñez L, Ong K, Valls C, Marcos MV, Dunger DB, de Zegher F (August 2006). "Metformin treatment to prevent early puberty in girls with precocious pubarche". The Journal of Clinical Endocrinology and Metabolism. 91 (8): 2888–91. doi:10.1210/jc.2006-0336. PMID 16684823.
Ibáñez L, López-Bermejo A, Díaz M, Marcos MV, de Zegher F (August 2011). "Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence". The Journal of Clinical Endocrinology and Metabolism. 96 (8): E1262-7. doi:10.1210/jc.2011-0555. PMID 21632811.
Ibáñez L, Díaz R, López-Bermejo A, Marcos MV (March 2009). "Clinical spectrum of premature pubarche: links to metabolic syndrome and ovarian hyperandrogenism". Reviews in Endocrine & Metabolic Disorders. 10 (1): 63–76. doi:10.1007/s11154-008-9096-y. PMID 18726694. S2CID 9129907.
Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, et al. (2022). "Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms". Theranostics. 12 (6): 2722–2740. doi:10.7150/thno.71360. PMC 8965502. PMID 35401820.
Hu D, Xie F, Xiao Y, Lu C, Zhong J, Huang D, et al. (April 2021). "Metformin: A Potential Candidate for Targeting Aging Mechanisms". Aging and Disease. 12 (2): 480–493. doi:10.14336/AD.2020.0702. PMC 7990352. PMID 33815878.
Piskovatska V, Storey KB, Vaiserman AM, Lushchak O (2020). "The Use of Metformin to Increase the Human Healthspan". Reviews on New Drug Targets in Age-Related Disorders. Advances in Experimental Medicine and Biology. Vol. 1260. pp. 319–332. doi:10.1007/978-3-030-42667-5_13. ISBN 978-3-030-42666-8. PMID 32304040.
Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA (June 2016). "Metformin as a Tool to Target Aging". Cell Metabolism. 23 (6): 1060–1065. doi:10.1016/j.cmet.2016.05.011. PMC 5943638. PMID 27304507.
Kulkarni AS, Gubbi S, Barzilai N (July 2020). "Benefits of Metformin in Attenuating the Hallmarks of Aging". Cell Metabolism. 32 (1): 15–30. doi:10.1016/j.cmet.2020.04.001. PMC 7347426. PMID 32333835.
Mohammed I, Hollenberg MD, Ding H, Triggle CR (2021). "A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan". Frontiers in Endocrinology. 12 718942. doi:10.3389/fendo.2021.718942. PMC 8374068. PMID 34421827.
Lee CG, Heckman-Stoddard B, Dabelea D, Gadde KM, Ehrmann D, Ford L, et al. (December 2021). "Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study". Diabetes Care. 44 (12): 2775–2782. doi:10.2337/dc21-1046. PMC 8669534. PMID 34697033.
Zhang J, Wen L, Zhou Q, He K, Teng L (16 September 2020). "Preventative and Therapeutic Effects of Metformin in Gastric Cancer: A New Contribution of an Old Friend". Cancer Management and Research. 12: 8545–8554. doi:10.2147/CMAR.S264032. PMC 7505710. PMID 32982447.
Bramante CT, Boulware DR (March 2026). "Preventing Long COVID With Metformin". Clinical Infectious Diseases. 82 (3) e433–e435. doi:10.1093/cid/ciaf700. PMC 13017490. PMID 41608911.
Li Y, Yang X, Yan P, Sun T, Zeng Z, Li S (2021). "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis". Frontiers in Medicine. 8 704666. doi:10.3389/fmed.2021.704666. PMC 8416892. PMID 34490296.
Ibrahim S, Lowe JR, Bramante CT, Shah S, Klatt NR, Sherwood N, et al. (2021). "Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit". Frontiers in Endocrinology. 12 587801. doi:10.3389/fendo.2021.587801. PMC 8342037. PMID 34367059.
Bramante CT, Ingraham NE, Murray TA, Marmor S, Hovertsen S, Gronski J, et al. (January 2021). "Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis". The Lancet. Healthy Longevity. 2 (1): e34–e41. doi:10.1016/S2666-7568(20)30033-7. PMC 7832552. PMID 33521772.
Gantois I, Popic J, Khoutorsky A, Sonenberg N (January 2019). "Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders". Annual Review of Medicine. 70: 167–181. doi:10.1146/annurev-med-081117-041238. PMID 30365357. S2CID 53093694. Archived from the original on 6 March 2023. Retrieved 9 October 2022.
Campbell JM, Stephenson MD, de Courten B, Chapman I, Bellman SM, Aromataris E (2018). "Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis". Journal of Alzheimer's Disease. 65 (4): 1225–1236. doi:10.3233/jad-180263. PMC 6218120. PMID 30149446.
Campbell JM, Stephenson MD, de Courten B, Chapman I, Bellman SM, Aromataris E (August 2017). "Metformin and Alzheimer's disease, dementia and cognitive impairment: a systematic review protocol". JBI Database of Systematic Reviews and Implementation Reports. 15 (8): 2055–2059. doi:10.11124/JBISRIR-2017-003380. PMID 28800055.
Lam TG, Jeong YS, Kim SA, Ahn SG (March 2018). "New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways". Cancer Science. 109 (3): 699–709. doi:10.1111/cas.13482. PMC 5834796. PMID 29285837.
Tsogbadrakh B, Ju KD, Lee J, Han M, Koh J, Yu Y, et al. (2018). "HL156A, a novel pharmacological agent with potent AMP-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model". PLOS ONE. 13 (8) e0201692. Bibcode:2018PLoSO..1301692T. doi:10.1371/journal.pone.0201692. PMC 6116936. PMID 30161162.
Jeong YS, Lam TG, Jeong S, Ahn SG (August 2020). "Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells". Pharmaceuticals. 13 (9): 218. doi:10.3390/ph13090218. PMC 7560051. PMID 32872293.
Kim SA, Lam TG, Yook JI, Ahn SG (September 2018). "Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice". Aging. 10 (9): 2338–2355. doi:10.18632/aging.101549. PMC 6188477. PMID 30222592.
Choi J, Lee JH, Koh I, Shim JK, Park J, Jeon JY, et al. (October 2016). "Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)". Oncotarget. 7 (40): 65643–65659. doi:10.18632/oncotarget.11595. PMC 5323181. PMID 27582539.
Ju KD, Kim HJ, Tsogbadrakh B, Lee J, Ryu H, Cho EJ, et al. (March 2016). "HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis". American Journal of Physiology. Renal Physiology. 310 (5): F342-50. doi:10.1152/ajprenal.00204.2015. PMID 26661649.

ncbi.nlm.nih.gov

Lucis OJ (January 1983). "The status of metformin in Canada". Canadian Medical Association Journal. 128 (1): 24–6. PMC 1874707. PMID 6847752.
de Silva VA, Suraweera C, Ratnatunga SS, Dayabandara M, Wanniarachchi N, Hanwella R (October 2016). "Metformin in prevention and treatment of antipsychotic-induced weight gain: a systematic review and meta-analysis". BMC Psychiatry. 16 (1) 341. doi:10.1186/s12888-016-1049-5. PMC 5048618. PMID 27716110.
Lin H, Ao H, Guo G, Liu M (2023). "The Role and Mechanism of Metformin in Inflammatory Diseases". Journal of Inflammation Research. 16: 5545–5564. doi:10.2147/JIR.S436147. PMC 10680465. PMID 38026260.
Blumenberg A, Benabbas R, Sinert R, Jeng A, Wiener SW (April 2020). "Do Patients Die with or from Metformin-Associated Lactic Acidosis (MALA)? Systematic Review and Meta-analysis of pH and Lactate as Predictors of Mortality in MALA". Journal of Medical Toxicology. 16 (2): 222–229. doi:10.1007/s13181-019-00755-6. PMC 7099117. PMID 31907741.
Lipska KJ, Bailey CJ, Inzucchi SE (June 2011). "Use of metformin in the setting of mild-to-moderate renal insufficiency". Diabetes Care. 34 (6): 1431–7. doi:10.2337/dc10-2361. PMC 3114336. PMID 21617112.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, et al. (February 2020). "GDF15 mediates the effects of metformin on body weight and energy balance". Nature. 578 (7795): 444–448. Bibcode:2020Natur.578..444C. doi:10.1038/s41586-019-1911-y. PMC 7234839. PMID 31875646.
LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, et al. (March 2022). "Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis". Proceedings of the National Academy of Sciences of the United States of America. 119 (10) e2122287119. Bibcode:2022PNAS..11922287L. doi:10.1073/pnas.2122287119. PMC 8916010. PMID 35238637.
Lord JM, Flight IH, Norman RJ (October 2003). "Metformin in polycystic ovary syndrome: systematic review and meta-analysis". BMJ. 327 (7421): 951–3. doi:10.1136/bmj.327.7421.951. PMC 259161. PMID 14576245.
Bennett WL, Maruthur NM, Singh S, Segal JB, Wilson LM, Chatterjee R, et al. (May 2011). "Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations". Annals of Internal Medicine. 154 (9): 602–13. doi:10.7326/0003-4819-154-9-201105030-00336. PMC 3733115. PMID 21403054.
Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. (June 2012). "Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)". Diabetes Care. 35 (6): 1364–79. doi:10.2337/dc12-0413. PMC 3357214. PMID 22517736.
Mead E, Atkinson G, Richter B, Metzendorf MI, Baur L, Finer N, et al. (November 2016). "Drug interventions for the treatment of obesity in children and adolescents". The Cochrane Database of Systematic Reviews. 11 (11) CD012436. doi:10.1002/14651858.CD012436. hdl:10149/620651. PMC 6472619. PMID 27899001.
Madsen KS, Chi Y, Metzendorf MI, Richter B, Hemmingsen B, et al. (Cochrane Metabolic and Endocrine Disorders Group) (December 2019). "Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 2019 (12) CD008558. doi:10.1002/14651858.CD008558.pub2. PMC 6889926. PMID 31794067.
Morley LC, Tang T, Yasmin E, Norman RJ, Balen AH (November 2017). "Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility". The Cochrane Database of Systematic Reviews. 11 (2) CD003053. doi:10.1002/14651858.CD003053.pub6. PMC 6486196. PMID 29183107. Our updated review suggests that metformin alone may be beneficial over a placebo for live birth, although the evidence quality was low.
Kumar P, Khan K (May 2012). "Effects of metformin use in pregnant patients with polycystic ovary syndrome". Journal of Human Reproductive Sciences. 5 (2): 166–9. doi:10.4103/0974-1208.101012. PMC 3493830. PMID 23162354.
Tso LO, Costello MF, Albuquerque LE, Andriolo RB, Macedo CR (December 2020). "Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome". The Cochrane Database of Systematic Reviews. 2020 (12) CD006105. doi:10.1002/14651858.CD006105.pub4. PMC 8171384. PMID 33347618.
Dodd JM, Grivell RM, Deussen AR, Hague WM (July 2018). "Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes". The Cochrane Database of Systematic Reviews. 2018 (7) CD010564. doi:10.1002/14651858.CD010564.pub2. PMC 6513233. PMID 30039871.
Balsells M, García-Patterson A, Solà I, Roqué M, Gich I, Corcoy R (January 2015). "Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis". BMJ (Systematic Review & Meta-Analysis). 350: h102. doi:10.1136/bmj.h102. PMC 4301599. PMID 25609400.
Tarry-Adkins JL, Aiken CE, Ozanne SE (August 2019). "Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis". PLOS Medicine. 16 (8) e1002848. doi:10.1371/journal.pmed.1002848. PMC 6684046. PMID 31386659.
Yerevanian A, Soukas AA (June 2019). "Metformin: Mechanisms in Human Obesity and Weight Loss". Current Obesity Reports. 8 (2): 156–164. doi:10.1007/s13679-019-00335-3. PMC 6520185. PMID 30874963.
Choi YJ (2015). "Efficacy of adjunctive treatments added to olanzapine or clozapine for weight control in patients with schizophrenia: a systematic review and meta-analysis". TheScientificWorldJournal. 2015 970730. doi:10.1155/2015/970730. PMC 4310265. PMID 25664341.
Praharaj SK, Jana AK, Goyal N, Sinha VK (March 2011). "Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis". British Journal of Clinical Pharmacology. 71 (3): 377–82. doi:10.1111/j.1365-2125.2010.03783.x. PMC 3045546. PMID 21284696.
Yu O, Lu M, Lai TK, Hahn M, Agarwal SM, O'Donoghue B, et al. (2024). "Metformin co-commencement at time of antipsychotic initiation for attenuation of weight gain: a systematic review and meta-analysis". Therapeutic Advances in Psychopharmacology. 14 20451253241255476. doi:10.1177/20451253241255476. PMC 11141220. PMID 38827016.
Siskind DJ, Leung J, Russell AW, Wysoczanski D, Kisely S (2016). "Metformin for Clozapine Associated Obesity: A Systematic Review and Meta-Analysis". PLOS ONE. 11 (6) e0156208. Bibcode:2016PLoSO..1156208S. doi:10.1371/journal.pone.0156208. PMC 4909277. PMID 27304831.
Mohamed S (October 2024). "Metformin: Diverse molecular mechanisms, gastrointestinal effects and overcoming intolerance in type 2 Diabetes Mellitus: A review". Medicine. 103 (43) e40221. doi:10.1097/MD.0000000000040221. PMC 11521032. PMID 39470509.
Ahmad R, Haque M (October 2024). "Metformin: Beyond Type 2 Diabetes Mellitus". Cureus. 16 (10) e71730. doi:10.7759/cureus.71730. PMC 11486535. PMID 39421288.
Heaf J (June 2014). "Metformin in chronic kidney disease: time for a rethink". Peritoneal Dialysis International. 34 (4): 353–357. doi:10.3747/pdi.2013.00344. PMC 4079480. PMID 24711640.
Nabrdalik K, Hendel M, Irlik K, Kwiendacz H, Łoniewski I, Bucci T, et al. (September 2024). "Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies". BMC Endocrine Disorders. 24 (1) 206. doi:10.1186/s12902-024-01727-w. PMC 11440709. PMID 39350158.
de Jager J, Kooy A, Lehert P, Wulffelé MG, van der Kolk J, Bets D, et al. (May 2010). "Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial". BMJ. 340 c2181. doi:10.1136/bmj.c2181. PMC 2874129. PMID 20488910.
Ramzan NU, Shahjahan K, Dhillon RA, Khan NT, Hashmat MB, Anwer MU, et al. (September 2024). "Vitamin B12 Deficiency in Patients Taking Metformin: Pathogenesis and Recommendations". Cureus. 16 (9) e68550. doi:10.7759/cureus.68550. PMC 11374140. PMID 39233729.
Inzucchi SE, Lipska KJ, Mayo H, Bailey CJ, McGuire DK (2014). "Metformin in patients with type 2 diabetes and kidney disease: a systematic review". JAMA. 312 (24): 2668–75. doi:10.1001/jama.2014.15298. PMC 4427053. PMID 25536258.
Suchard JR, Grotsky TA (August 2008). "Fatal metformin overdose presenting with progressive hyperglycemia". The Western Journal of Emergency Medicine. 9 (3): 160–4. PMC 2672258. PMID 19561734.
Somogyi A, Stockley C, Keal J, Rolan P, Bochner F (May 1987). "Reduction of metformin renal tubular secretion by cimetidine in man". British Journal of Clinical Pharmacology. 23 (5): 545–51. doi:10.1111/j.1365-2125.1987.tb03090.x. PMC 1386190. PMID 3593625.
May M, Schindler C (April 2016). "Clinically and pharmacologically relevant interactions of antidiabetic drugs". Therapeutic Advances in Endocrinology and Metabolism. 7 (2): 69–83. doi:10.1177/2042018816638050. PMC 4821002. PMID 27092232.
Rena G, Pearson ER, Sakamoto K (September 2013). "Molecular mechanism of action of metformin: old or new insights?". Diabetologia. 56 (9): 1898–906. doi:10.1007/s00125-013-2991-0. PMC 3737434. PMID 23835523.
Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, et al. (June 2014). "Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase". Nature. 510 (7506): 542–6. Bibcode:2014Natur.510..542M. doi:10.1038/nature13270. PMC 4074244. PMID 24847880.
Hundal RS, Krssak M, Dufour S, Laurent D, Lebon V, Chandramouli V, et al. (December 2000). "Mechanism by which metformin reduces glucose production in type 2 diabetes". Diabetes. 49 (12): 2063–9. doi:10.2337/diabetes.49.12.2063. PMC 2995498. PMID 11118008.
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. (October 2001). "Role of AMP-activated protein kinase in mechanism of metformin action". The Journal of Clinical Investigation. 108 (8): 1167–74. doi:10.1172/JCI13505. PMC 209533. PMID 11602624.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, et al. (March 2022). "Low-dose metformin targets the lysosomal AMPK pathway through PEN2". Nature. 603 (7899): 159–165. Bibcode:2022Natur.603..159M. doi:10.1038/s41586-022-04431-8. PMC 8891018. PMID 35197629.
Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ (February 2013). "Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP". Nature. 494 (7436): 256–60. Bibcode:2013Natur.494..256M. doi:10.1038/nature11808. PMC 3573218. PMID 23292513.
Hardie DG, Ross FA, Hawley SA (March 2012). "AMPK: a nutrient and energy sensor that maintains energy homeostasis". Nature Reviews. Molecular Cell Biology. 13 (4): 251–262. doi:10.1038/nrm3311. PMC 5726489. PMID 22436748.
LaMoia TE, Shulman GI (January 2021). "Cellular and Molecular Mechanisms of Metformin Action". Endocrine Reviews. 42 (1): 77–96. doi:10.1210/endrev/bnaa023. PMC 7846086. PMID 32897388.
Weersma RK, Zhernakova A, Fu J (August 2020). "Interaction between drugs and the gut microbiome". Gut. 69 (8): 1510–1519. doi:10.1136/gutjnl-2019-320204. PMC 7398478. PMID 32409589.
Guerrieri D, Moon HY, van Praag H (March 2017). "Exercise in a Pill: The Latest on Exercise-Mimetics". Brain Plasticity. 2 (2): 153–169. doi:10.3233/BPL-160043. PMC 5928571. PMID 29765854.
Boulé NG, Robert C, Bell GJ, Johnson ST, Bell RC, Lewanczuk RZ, et al. (July 2011). "Metformin and exercise in type 2 diabetes: examining treatment modality interactions". Diabetes Care. 34 (7): 1469–1474. doi:10.2337/dc10-2207. PMC 3120188. PMID 21602430.
Pryor R, Cabreiro F (November 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". The Biochemical Journal. 471 (3): 307–22. doi:10.1042/bj20150497. PMC 4613459. PMID 26475449.
Witters LA (October 2001). "The blooming of the French lilac". The Journal of Clinical Investigation. 108 (8): 1105–7. doi:10.1172/JCI14178. PMC 209536. PMID 11602616.
Dawes GS, Mott JC (March 1950). "Circulatory and respiratory reflexes caused by aromatic guanidines". British Journal of Pharmacology and Chemotherapy. 5 (1): 65–76. doi:10.1111/j.1476-5381.1950.tb00578.x. PMC 1509951. PMID 15405470.
Christofides EA (July 2019). "Practical Insights Into Improving Adherence to Metformin Therapy in Patients With Type 2 Diabetes". Clinical Diabetes. 37 (3): 234–241. doi:10.2337/cd18-0063. PMC 6640881. PMID 31371854.
Kaushik D, Karnes RJ, Eisenberg MS, Rangel LJ, Carlson RE, Bergstralh EJ (January 2014). "Effect of metformin on prostate cancer outcomes after radical prostatectomy". Urologic Oncology. 32 (1): 43.e1–7. doi:10.1016/j.urolonc.2013.05.005. PMC 4006350. PMID 23810664.
Sheehan MT (July 2003). "Current therapeutic options in type 2 diabetes mellitus: a practical approach". Clinical Medicine & Research. 1 (3): 189–200. doi:10.3121/cmr.1.3.189. PMC 1069045. PMID 15931309.
Madsen KS, Kähler P, Kähler LK, Madsbad S, Gnesin F, Metzendorf MI, et al. (Cochrane Metabolic and Endocrine Disorders Group) (April 2019). "Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus". The Cochrane Database of Systematic Reviews. 4 (4) CD012368. doi:10.1002/14651858.CD012368.pub2. PMC 6472662. PMID 30998259.
Dutta S, Shah RB, Singhal S, Dutta SB, Bansal S, Sinha S, et al. (2023). "Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes". Drug Des Devel Ther. 17: 1907–1932. doi:10.2147/DDDT.S409373. PMC 10312383. PMID 37397787.
Froldi G (April 2024). "View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences". Pharmaceuticals. 17 (4): 478. doi:10.3390/ph17040478. PMC 11054066. PMID 38675438.
Soukas AA, Hao H, Wu L (October 2019). "Metformin as Anti-Aging Therapy: Is It for Everyone?". Trends in Endocrinology and Metabolism. 30 (10): 745–755. doi:10.1016/j.tem.2019.07.015. PMC 6779524. PMID 31405774.
Novelle MG, Ali A, Diéguez C, Bernier M, de Cabo R (March 2016). "Metformin: A Hopeful Promise in Aging Research". Cold Spring Harbor Perspectives in Medicine. 6 (3) a025932. doi:10.1101/cshperspect.a025932. PMC 4772077. PMID 26931809.
Malek M, Aghili R, Emami Z, Khamseh ME (September 2013). "Risk of cancer in diabetes: the effect of metformin". ISRN Endocrinology. 2013 636927. doi:10.1155/2013/636927. PMC 3800579. PMID 24224094.
Blazina I, Selph S (November 2019). "Diabetes drugs for nonalcoholic fatty liver disease: a systematic review". Systematic Reviews. 8 (1) 295. doi:10.1186/s13643-019-1200-8. PMC 6884753. PMID 31783920.
Leoni S, Tovoli F, Napoli L, Serio I, Ferri S, Bolondi L (August 2018). "Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis". World Journal of Gastroenterology. 24 (30): 3361–3373. doi:10.3748/wjg.v24.i30.3361. PMC 6092580. PMID 30122876.
Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, et al. (2022). "Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms". Theranostics. 12 (6): 2722–2740. doi:10.7150/thno.71360. PMC 8965502. PMID 35401820.
Hu D, Xie F, Xiao Y, Lu C, Zhong J, Huang D, et al. (April 2021). "Metformin: A Potential Candidate for Targeting Aging Mechanisms". Aging and Disease. 12 (2): 480–493. doi:10.14336/AD.2020.0702. PMC 7990352. PMID 33815878.
Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA (June 2016). "Metformin as a Tool to Target Aging". Cell Metabolism. 23 (6): 1060–1065. doi:10.1016/j.cmet.2016.05.011. PMC 5943638. PMID 27304507.
Kulkarni AS, Gubbi S, Barzilai N (July 2020). "Benefits of Metformin in Attenuating the Hallmarks of Aging". Cell Metabolism. 32 (1): 15–30. doi:10.1016/j.cmet.2020.04.001. PMC 7347426. PMID 32333835.
Mohammed I, Hollenberg MD, Ding H, Triggle CR (2021). "A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan". Frontiers in Endocrinology. 12 718942. doi:10.3389/fendo.2021.718942. PMC 8374068. PMID 34421827.
Lee CG, Heckman-Stoddard B, Dabelea D, Gadde KM, Ehrmann D, Ford L, et al. (December 2021). "Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study". Diabetes Care. 44 (12): 2775–2782. doi:10.2337/dc21-1046. PMC 8669534. PMID 34697033.
Zhang J, Wen L, Zhou Q, He K, Teng L (16 September 2020). "Preventative and Therapeutic Effects of Metformin in Gastric Cancer: A New Contribution of an Old Friend". Cancer Management and Research. 12: 8545–8554. doi:10.2147/CMAR.S264032. PMC 7505710. PMID 32982447.
Bramante CT, Boulware DR (March 2026). "Preventing Long COVID With Metformin". Clinical Infectious Diseases. 82 (3) e433–e435. doi:10.1093/cid/ciaf700. PMC 13017490. PMID 41608911.
Li Y, Yang X, Yan P, Sun T, Zeng Z, Li S (2021). "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis". Frontiers in Medicine. 8 704666. doi:10.3389/fmed.2021.704666. PMC 8416892. PMID 34490296.
Ibrahim S, Lowe JR, Bramante CT, Shah S, Klatt NR, Sherwood N, et al. (2021). "Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit". Frontiers in Endocrinology. 12 587801. doi:10.3389/fendo.2021.587801. PMC 8342037. PMID 34367059.
Bramante CT, Ingraham NE, Murray TA, Marmor S, Hovertsen S, Gronski J, et al. (January 2021). "Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis". The Lancet. Healthy Longevity. 2 (1): e34–e41. doi:10.1016/S2666-7568(20)30033-7. PMC 7832552. PMID 33521772.
Campbell JM, Stephenson MD, de Courten B, Chapman I, Bellman SM, Aromataris E (2018). "Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis". Journal of Alzheimer's Disease. 65 (4): 1225–1236. doi:10.3233/jad-180263. PMC 6218120. PMID 30149446.
Lam TG, Jeong YS, Kim SA, Ahn SG (March 2018). "New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways". Cancer Science. 109 (3): 699–709. doi:10.1111/cas.13482. PMC 5834796. PMID 29285837.
Tsogbadrakh B, Ju KD, Lee J, Han M, Koh J, Yu Y, et al. (2018). "HL156A, a novel pharmacological agent with potent AMP-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model". PLOS ONE. 13 (8) e0201692. Bibcode:2018PLoSO..1301692T. doi:10.1371/journal.pone.0201692. PMC 6116936. PMID 30161162.
Jeong YS, Lam TG, Jeong S, Ahn SG (August 2020). "Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells". Pharmaceuticals. 13 (9): 218. doi:10.3390/ph13090218. PMC 7560051. PMID 32872293.
Kim SA, Lam TG, Yook JI, Ahn SG (September 2018). "Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice". Aging. 10 (9): 2338–2355. doi:10.18632/aging.101549. PMC 6188477. PMID 30222592.
Choi J, Lee JH, Koh I, Shim JK, Park J, Jeon JY, et al. (October 2016). "Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)". Oncotarget. 7 (40): 65643–65659. doi:10.18632/oncotarget.11595. PMC 5323181. PMID 27582539.

dailymed.nlm.nih.gov

"Glucophage (metformin hydrochloride) tablets, for oral use; Glucophage XR (metformin hydrochloride) extended-release tablets, for oral use Initial U.S. Approval:1995". DailyMed. Archived from the original on 6 March 2023. Retrieved 5 March 2023.
"Glucophage package insert". Princeton, NJ: Bristol-Myers Squibb Company. 2009. Archived from the original on 29 August 2021 – via DailyMed.
"Janumet- sitagliptin and metformin hydrochloride tablet, film coated". DailyMed. 12 August 2019. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Kombiglyze XR- saxagliptin and metformin hydrochloride tablet, film coated, extended release". DailyMed. 24 October 2019. Archived from the original on 25 September 2020. Retrieved 15 May 2020.
"Kazano- alogliptin and metformin hydrochloride tablet, film coated". DailyMed. 14 June 2019. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Jentadueto- linagliptin and metformin hydrochloride tablet, film coated". DailyMed. 18 July 2019. Archived from the original on 9 June 2021. Retrieved 31 March 2020.
"Jentadueto XR- linagliptin and metformin hydrochloride tablet, film coated, extended release". DailyMed. Archived from the original on 5 October 2021. Retrieved 4 October 2021.
"Qternmet XR (dapagliflozin, saxagliptin, and metformin hydrochloride) extended-release tablets, for oral use Initial U.S. Approval: 2019". DailyMed. Archived from the original on 6 March 2023. Retrieved 5 March 2023.

nytimes.com (Global: 7^th place; English: 7^th place)

Harris G (19 February 2010). "Controversial Diabetes Drug Harms Heart, U.S. Concludes". The New York Times. Archived from the original on 19 March 2017.

prnewswire.com (Global: 546^th place; English: 310^th place)

"Lupin Pharmaceuticals, Inc. Issues Voluntarily Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets, 500mg and 1000mg Due to the Detection of N-Nitrosodimethylamine (NDMA) Impurity" (Press release). Lupin Pharmaceuticals Inc. Archived from the original on 9 June 2021. Retrieved 9 July 2020 – via PR Newswire.

qub.ac.uk (Global: 8,484^th place; English: 4,941^st place)

pure.qub.ac.uk

Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, et al. (February 2018). "Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis". Diabetic Medicine. 35 (2): 160–172. doi:10.1111/dme.13523. hdl:10453/130987. PMID 29044702. S2CID 40045912. Archived from the original on 29 April 2023. Retrieved 7 April 2023.

rcog.org.uk (Global: low place; English: low place)

Balen A (December 2008). "Metformin therapy for the management of infertility in women with polycystic ovary syndrome" (PDF). Scientific Advisory Committee Opinion Paper 13. Royal College of Obstetricians and Gynaecologists. Archived from the original (PDF) on 18 December 2009. Retrieved 13 December 2009.

rcpe.ac.uk (Global: low place; English: low place)

Hadden DR (October 2005). "Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection" (PDF). The Journal of the Royal College of Physicians of Edinburgh. 35 (3): 258–60. doi:10.1177/1478271520053503010. PMID 16402501. Archived (PDF) from the original on 25 October 2020. Retrieved 21 December 2009.

regulations.gov (Global: low place; English: 8,383^rd place)

downloads.regulations.gov

Cavazzoni P (28 May 2020). "Re: Docket No. FDA-2020-P-0978" (PDF). U.S. Food and Drug Administration (FDA). Archived (PDF) from the original on 8 February 2021. Retrieved 2 June 2020.

reuters.com (Global: 38^th place; English: 30^th place)

"Teva Pharm announces settlement of generic Avandia, Avandamet, and Avandaryl litigation with GlaxoSmithKline". Reuters. 27 September 2007. Archived from the original on 3 May 2021. Retrieved 17 February 2009.

semanticscholar.org (Global: 15^th place; English: 8^th place)

api.semanticscholar.org

Sirtori CR, Franceschini G, Galli-Kienle M, Cighetti G, Galli G, Bondioli A, et al. (December 1978). "Disposition of metformin (N,N-dimethylbiguanide) in man". Clinical Pharmacology and Therapeutics. 24 (6): 683–93. doi:10.1002/cpt1978246683. PMID 710026. S2CID 24531910.
Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, Freeman R, et al. (January 2022). "9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022". Diabetes Care. 45 (Suppl 1): S125–S143. doi:10.2337/dc22-s009. PMID 34964831. S2CID 245538347.
Maruthur NM, Tseng E, Hutfless S, Wilson LM, Suarez-Cuervo C, Berger Z, et al. (June 2016). "Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes: A Systematic Review and Meta-analysis". Annals of Internal Medicine. 164 (11): 740–751. doi:10.7326/M15-2650. PMID 27088241. S2CID 32016657.
Triggle CR, Ding H (January 2017). "Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium". Acta Physiologica. 219 (1): 138–151. doi:10.1111/apha.12644. PMID 26680745. S2CID 312517.
Day EA, Ford RJ, Smith BK, Mohammadi-Shemirani P, Morrow MR, Gutgesell RM, et al. (December 2019). "Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss". Nature Metabolism. 1 (12): 1202–1208. doi:10.1038/s42255-019-0146-4. PMID 32694673. S2CID 213199603.
Pappachan JM, Viswanath AK (January 2017). "Medical Management of Diabesity: Do We Have Realistic Targets?". Current Diabetes Reports. 17 (1) 4. doi:10.1007/s11892-017-0828-9. PMID 28101792. S2CID 10289148.
Ghazeeri GS, Nassar AH, Younes Z, Awwad JT (June 2012). "Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview". Acta Obstetricia et Gynecologica Scandinavica. 91 (6): 658–78. doi:10.1111/j.1600-0412.2012.01385.x. PMID 22375613. S2CID 41145972.
Diamanti-Kandarakis E, Economou F, Palimeri S, Christakou C (September 2010). "Metformin in polycystic ovary syndrome". Annals of the New York Academy of Sciences. 1205 (1): 192–8. Bibcode:2010NYASA1205..192D. doi:10.1111/j.1749-6632.2010.05679.x. PMID 20840272. S2CID 44203632.
Butalia S, Gutierrez L, Lodha A, Aitken E, Zakariasen A, Donovan L (January 2017). "Short- and long-term outcomes of metformin compared with insulin alone in pregnancy: a systematic review and meta-analysis". Diabetic Medicine. 34 (1): 27–36. doi:10.1111/dme.13150. PMID 27150509. S2CID 3418227.
Nicholson W, Bolen S, Witkop CT, Neale D, Wilson L, Bass E (January 2009). "Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review". Obstetrics and Gynecology. 113 (1): 193–205. doi:10.1097/AOG.0b013e318190a459. PMID 19104375. S2CID 28115952.
Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, et al. (February 2018). "Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis". Diabetic Medicine. 35 (2): 160–172. doi:10.1111/dme.13523. hdl:10453/130987. PMID 29044702. S2CID 40045912. Archived from the original on 29 April 2023. Retrieved 7 April 2023.
Khurana R, Malik IS (January 2010). "Metformin: safety in cardiac patients". Heart. 96 (2): 99–102. doi:10.1136/hrt.2009.173773. PMID 19564648. S2CID 9746741.
Fujita Y, Inagaki N (January 2017). "Metformin: New Preparations and Nonglycemic Benefits". Current Diabetes Reports. 17 (1) 5. doi:10.1007/s11892-017-0829-8. PMID 28116648. S2CID 9277684.
Wulffelé MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, et al. (November 2003). "Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial". Journal of Internal Medicine. 254 (5): 455–63. doi:10.1046/j.1365-2796.2003.01213.x. PMID 14535967. S2CID 12507226.
Kirpichnikov D, McFarlane SI, Sowers JR (July 2002). "Metformin: an update". Annals of Internal Medicine. 137 (1): 25–33. doi:10.7326/0003-4819-137-1-200207020-00009. PMID 12093242. S2CID 9140541.
Forrester MB (July 2008). "Adult metformin ingestions reported to Texas poison control centers, 2000-2006". Human & Experimental Toxicology. 27 (7): 575–83. Bibcode:2008HETox..27..575F. doi:10.1177/0960327108090589. PMID 18829734. S2CID 5413561.
Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, et al. (August 2015). "Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup". Critical Care Medicine. 43 (8): 1716–30. doi:10.1097/CCM.0000000000001002. PMID 25860205. S2CID 13861731.
Teale KF, Devine A, Stewart H, Harper NJ (July 1998). "The management of metformin overdose". Anaesthesia. 53 (7): 698–701. doi:10.1046/j.1365-2044.1998.436-az0549.x. PMID 9771180. S2CID 45218798.
Jayasagar G, Krishna Kumar M, Chandrasekhar K, Madhusudan Rao C, Madhusudan Rao Y (2002). "Effect of cephalexin on the pharmacokinetics of metformin in healthy human volunteers". Drug Metabolism and Drug Interactions. 19 (1): 41–8. doi:10.1515/dmdi.2002.19.1.41. PMID 12222753. S2CID 26919498.
Burcelin R (May 2014). "The antidiabetic gutsy role of metformin uncovered?". Gut. 63 (5): 706–7. doi:10.1136/gutjnl-2013-305370. PMID 23840042. S2CID 42142919.
Nikolakis G, Kyrgidis A, Zouboulis CC (August 2019). "Is There a Role for Antiandrogen Therapy for Hidradenitis Suppurativa? A Systematic Review of Published Data". American Journal of Clinical Dermatology. 20 (4): 503–513. doi:10.1007/s40257-019-00442-w. PMID 31073704. S2CID 149443722.
MacNeil LT, Schertzer JD, Steinberg GR (January 2020). "Bacteria transmit metformin-associated lifespan extension". Nature Reviews. Endocrinology. 16 (1): 9–10. doi:10.1038/s41574-019-0278-3. PMID 31645681. S2CID 204836737.
Jones GR, Molloy MP (June 2020). "Metformin, Microbiome and Protection Against Colorectal Cancer". Digestive Diseases and Sciences. 66 (5): 1409–1414. doi:10.1007/s10620-020-06390-4. PMID 32533543. S2CID 219607625.
Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, et al. (February 2011). "Clinical pharmacokinetics of metformin". Clinical Pharmacokinetics. 50 (2): 81–98. doi:10.2165/11534750-000000000-00000. PMID 21241070. S2CID 1440441.
Bailey CJ, Day C (2004). "Metformin: its botanical background". Practical Diabetes International. 21 (3): 115–17. doi:10.1002/pdi.606. S2CID 208203689.
Bailey CJ, Day C (June 2009). "Fixed-dose single tablet antidiabetic combinations". Diabetes, Obesity & Metabolism. 11 (6): 527–33. doi:10.1111/j.1463-1326.2008.00993.x. PMID 19175373. S2CID 6569131.
Panikar V, Chandalia HB, Joshi SR, Fafadia A, Santvana C (November 2003). "Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy". The Journal of the Association of Physicians of India. 51: 1061–4. PMID 15260389. S2CID 22085315.
Campbell JM, Bellman SM, Stephenson MD, Lisy K (November 2017). "Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis". Ageing Research Reviews. 40: 31–44. doi:10.1016/j.arr.2017.08.003. PMID 28802803. S2CID 20334490.
Jalali M, Rahimlou M, Mahmoodi M, Moosavian SP, Symonds ME, Jalali R, et al. (September 2020). "The effects of metformin administration on liver enzymes and body composition in non-diabetic patients with non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis: An up-to date systematic review and meta-analysis of randomized controlled trials". Pharmacological Research. 159 104799. doi:10.1016/j.phrs.2020.104799. PMID 32278041. S2CID 215741792.
Ibáñez L, Díaz R, López-Bermejo A, Marcos MV (March 2009). "Clinical spectrum of premature pubarche: links to metabolic syndrome and ovarian hyperandrogenism". Reviews in Endocrine & Metabolic Disorders. 10 (1): 63–76. doi:10.1007/s11154-008-9096-y. PMID 18726694. S2CID 9129907.
Gantois I, Popic J, Khoutorsky A, Sonenberg N (January 2019). "Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders". Annual Review of Medicine. 70: 167–181. doi:10.1146/annurev-med-081117-041238. PMID 30365357. S2CID 53093694. Archived from the original on 6 March 2023. Retrieved 9 October 2022.

stuff.co.nz (Global: 387^th place; English: 194^th place)

"Diabetes drug withdrawn". Stuff.co.nz. NZPA. 17 February 2011. Archived from the original on 13 October 2013. Retrieved 5 November 2011.

tga.gov.au (Global: 4,353^rd place; English: 2,806^th place)

"Metformin Sandoz metformin hydrochloride 850mg tablet bottle (148270)". Therapeutic Goods Administration (TGA). 27 May 2022. Retrieved 29 April 2023.
"Blooms Metformin XR (Medreich Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 13 September 2024. Retrieved 15 September 2024.

thewitfire.in (Global: low place; English: low place)

Sharma A (29 October 2023). "The Role of Metformin in Gastric Cancer Treatment". Witfire. Archived from the original on 3 November 2023. Retrieved 3 November 2023.

viamedica.pl (Global: low place; English: low place)

journals.viamedica.pl

Strojek K, Wróbel M, Szymborska-Kajanek A, Rokicka D (2013). "Metformin — new reimbursement indications". Clinical Diabetology (in Polish). 2 (4). ISSN 2450-8187. Archived from the original on 17 September 2021.

web.archive.org (Global: 1^st place; English: 1^st place)

"Metformin Use During Pregnancy". Drugs.com. 10 September 2019. Archived from the original on 16 April 2020. Retrieved 4 February 2020.
"Metformin Hydrochloride". Health Canada. Archived from the original on 6 March 2023. Retrieved 6 March 2023.
"Glucophage 500 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 25 October 2022. Archived from the original on 20 June 2022. Retrieved 5 March 2023.
"Glucophage (metformin hydrochloride) tablets, for oral use; Glucophage XR (metformin hydrochloride) extended-release tablets, for oral use Initial U.S. Approval:1995". DailyMed. Archived from the original on 6 March 2023. Retrieved 5 March 2023.
"Metformin and metformin-containing medicines". European Medicines Agency (EMA). 13 October 2016. Archived from the original on 18 November 2023. Retrieved 10 June 2024.
"Metformin". www.chemsrc.com. Archived from the original on 12 June 2017. Retrieved 10 May 2018.
"Metformin Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 24 December 2016. Retrieved 2 January 2017.
Fischer J (2010). Analogue-based Drug Discovery II. John Wiley & Sons. p. 49. ISBN 978-3-527-63212-1. Archived from the original on 8 September 2017.
Stargrove MB, Treasure J, McKee DL (2008). Herb, nutrient, and drug interactions: clinical implications and therapeutic strategies. St. Louis, Mo.: Mosby/Elsevier. p. 217. ISBN 978-0-323-02964-3. Archived from the original on 8 September 2017.
"The Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
"Medicines in the health system". Australian Institute of Health and Welfare. 2 July 2024. Archived from the original on 30 September 2024. Retrieved 30 September 2024.
"Glucophage package insert". Princeton, NJ: Bristol-Myers Squibb Company. 2009. Archived from the original on 29 August 2021 – via DailyMed.
National Collaborating Centre for Women's and Children's Health (2004). Fertility: assessment and treatment for people with fertility problems (PDF). London: Royal College of Obstetricians and Gynaecologists. pp. 58–59. ISBN 978-1-900364-97-3. Archived (PDF) from the original on 11 July 2009.
Strojek K, Wróbel M, Szymborska-Kajanek A, Rokicka D (2013). "Metformin — new reimbursement indications". Clinical Diabetology (in Polish). 2 (4). ISSN 2450-8187. Archived from the original on 17 September 2021.
Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, et al. (February 2018). "Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis". Diabetic Medicine. 35 (2): 160–172. doi:10.1111/dme.13523. hdl:10453/130987. PMID 29044702. S2CID 40045912. Archived from the original on 29 April 2023. Retrieved 7 April 2023.
"Metformin: medicine to treat type 2 diabetes". National Health Service. 25 February 2019. Archived from the original on 11 March 2021. Retrieved 15 October 2020.
"METFORMIN HYDROCHLORIDE". NICE. Archived from the original on 10 June 2021. Retrieved 15 October 2020.
Andrès E, Noel E, Goichot B (October 2002). "Metformin-associated vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (19): 2251–2. doi:10.1001/archinte.162.19.2251-a. PMID 12390080. Archived from the original on 10 June 2024. Retrieved 22 January 2024.
Gilligan MA (February 2002). "Metformin and vitamin B12 deficiency". Editor's Correspondence. Archives of Internal Medicine. 162 (4): 484–5. doi:10.1001/archinte.162.4.484. PMID 11863489. Archived from the original on 1 December 2020. Retrieved 22 January 2024.
"Vitamin B12 or folate deficiency anaemia - Symptoms". nhs.uk. 20 October 2017. Archived from the original on 22 November 2024. Retrieved 28 November 2024.
"FDA Drug Safety Communication: FDA revises warnings regarding the use of the diabetes medicine metformin in certain patients with reduced kidney function". U.S. Food and Drug Administration (FDA). 14 November 2017. Archived from the original on 25 May 2021. Retrieved 21 December 2018.
Heller JB (2007). "Metformin overdose in dogs and cats" (PDF). Veterinary Medicine (April): 231–33. Archived from the original (PDF) on 23 October 2007.
Werner E, Bell J (1922). "The preparation of methylguanidine, and of ββ-dimethylguanidine by the interaction of dicyandiamide, and methylammonium and dimethylammonium chlorides respectively". J. Chem. Soc., Trans. 121: 1790–95. doi:10.1039/CT9222101790. Archived from the original on 8 June 2021. Retrieved 4 September 2020.
"Statement from Janet Woodcock, M.D., director of FDA's Center for Drug Evaluation and Research, on impurities found in diabetes drugs outside the U.S." U.S. Food and Drug Administration (FDA). 5 December 2019. Archived from the original on 18 January 2021. Retrieved 4 February 2020. This article incorporates text from this source, which is in the public domain.
"Recalls and safety alerts". Health Canada evaluating NDMA in metformin drugs. 5 December 2019. Archived from the original on 17 April 2020. Retrieved 4 February 2020.
"Laboratory Tests - Metformin". U.S. Food and Drug Administration (FDA). 3 February 2020. Archived from the original on 25 February 2020. Retrieved 4 February 2020.
"FDA Updates and Press Announcements on NDMA in Metformin". U.S. Food and Drug Administration (FDA). 4 February 2020. Archived from the original on 25 February 2020. Retrieved 4 February 2020.
"APO-Metformin (2020-02-04)". Health Canada. 4 February 2020. Archived from the original on 27 December 2020. Retrieved 2 June 2020.
"Ranbaxy Metformin Product Recall (2020-02-26)". Health Canada. 26 February 2020. Archived from the original on 26 November 2020. Retrieved 2 June 2020.
"Jamp-Metformin Product Recall (2020-03-10)". Health Canada. 10 March 2020. Archived from the original on 26 November 2020. Retrieved 2 June 2020.
"FDA Alerts Patients and Health Care Professionals to Nitrosamine Impurity Findings in Certain Metformin Extended-Release Products" (Press release). U.S. Food and Drug Administration (FDA). 28 May 2020. Archived from the original on 22 March 2021. Retrieved 2 June 2020.
"Questions and Answers: NDMA impurities in metformin products". U.S. Food and Drug Administration (FDA). 28 May 2020. Archived from the original on 2 March 2021. Retrieved 5 June 2020.
"Amneal Pharmaceuticals LLC Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended Release Tablets, USP, 500 mg and 750 mg, Due to Detection of N-Nitrosodimethylamine (NDMA) Impurity". U.S. Food and Drug Administration (FDA). 29 May 2020. Archived from the original on 16 January 2021. Retrieved 2 June 2020.
"Apotex Corp. Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets 500mg Due to the Detection of N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 27 May 2020. Archived from the original on 4 March 2021. Retrieved 2 June 2020.
"Teva Pharmaceuticals USA, Inc. Initiates Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets USP 500 mg and 750 mg Due to Detection of N-Nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 2 June 2020. Archived from the original on 21 January 2021. Retrieved 5 June 2020.
"Marksans Pharma Limited Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets, USP 500mg, Due to the Detection of N-Nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 2 June 2020. Archived from the original on 23 January 2021. Retrieved 5 June 2020.
Cavazzoni P (28 May 2020). "Re: Docket No. FDA-2020-P-0978" (PDF). U.S. Food and Drug Administration (FDA). Archived (PDF) from the original on 8 February 2021. Retrieved 2 June 2020.
"Laboratory Tests - Metformin". U.S. Food and Drug Administration (FDA). 5 June 2020. Archived from the original on 22 April 2021. Retrieved 5 June 2020. This article incorporates text from this source, which is in the public domain.
"Lupin Pharmaceuticals, Inc. Issues Voluntarily Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets, 500mg and 1000mg Due to the Detection of N-Nitrosodimethylamine (NDMA) Impurity" (Press release). Lupin Pharmaceuticals Inc. Archived from the original on 9 June 2021. Retrieved 9 July 2020 – via PR Newswire.
"Bayshore Pharmaceuticals, LLC Issues Voluntary Nationwide Recall of Metformin Hydrochloride Extended-Release Tablets USP, 500 mg and 750 mg Due to the Detection of N-Nitrosodimethylamine (NDMA) Impurity". U.S. Food and Drug Administration (FDA). 19 August 2020. Archived from the original on 19 December 2020. Retrieved 25 August 2020.
"Control of Nitrosamine Impurities in Human Drugs". U.S. Food and Drug Administration. 24 February 2021. Archived from the original on 24 September 2024. Retrieved 6 September 2024.
About Eusebio Y. Garcia, see: Carteciano J (2005). "Search for DOST-NRCP Dr. Eusebio Y. Garcia Award". Philippines Department of Science and Technology. Archived from the original on 24 October 2009. Retrieved 5 December 2009.
About Janusz Supniewski, see: Wołkow PP, Korbut R (April 2006). "Pharmacology at the Jagiellonian University in Kracow, short review of contribution to global science and cardiovascular research through 400 years of history" (PDF). Journal of Physiology and Pharmacology. 57 (Suppl 1): 119–136. PMID 16766803. Archived from the original (PDF) on 24 October 2009. Retrieved 22 December 2009.
Hadden DR (October 2005). "Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection" (PDF). The Journal of the Royal College of Physicians of Edinburgh. 35 (3): 258–60. doi:10.1177/1478271520053503010. PMID 16402501. Archived (PDF) from the original on 25 October 2020. Retrieved 21 December 2009.
"FDA Approves New Diabetes Drug" (Press release). U.S. Food and Drug Administration (FDA). 30 December 1994. Archived from the original on 29 September 2007. Retrieved 6 January 2007.
"Drug Approval Package: Glucophage (metformin)" (PDF). U.S. Food and Drug Administration (FDA). Archived from the original (PDF) on 5 February 2020. Retrieved 8 January 2007.
"Metformin Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 15 September 2024. Retrieved 15 September 2024.
"Metformin Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 8 December 2023. Retrieved 15 September 2024.
"EU/3/16/1803 - orphan designation for treatment of progressive myoclonic epilepsy type 2 (Lafora disease)". European Medicines Agency (EMA). 12 December 2016. Archived from the original on 15 September 2024. Retrieved 15 September 2024.
"Metformin". Drugs.com. Archived from the original on 28 November 2020. Retrieved 17 July 2020.
"Drug Approval Package: Avandamet (rosiglitazone maleate/metformin HCL) NDA #021410". U.S. Food and Drug Administration (FDA). 30 April 2003. Archived from the original on 10 June 2024. Retrieved 10 June 2024.
"FDA Approves GlaxoSmithKline's Avandamet (rosiglitazone maleate and metformin HCl), The Latest Advancement in the Treatment of Type 2 Diabetes" (Press release). GlaxoSmithKline. 12 October 2002. Archived from the original on 21 January 2007. Retrieved 27 December 2006.
"Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 21 March 2021. Retrieved 21 July 2020.
"2009 Top 200 branded drugs by total prescriptions" (PDF). Archived from the original (PDF) on 14 July 2011. (96.5 KB). Drug Topics (17 June 2010). Retrieved 2 September 2010.
"Questions and Answers about the Seizure of Paxil CR and Avandamet" (Press release). U.S. Food and Drug Administration (FDA). 4 March 2005. Archived from the original on 14 October 2007. Retrieved 27 December 2006.
"Teva Pharm announces settlement of generic Avandia, Avandamet, and Avandaryl litigation with GlaxoSmithKline". Reuters. 27 September 2007. Archived from the original on 3 May 2021. Retrieved 17 February 2009.
"European Medicines Agency recommends suspension of Avandia, Avandamet and Avaglim" (Press release). European Medicines Agency (EMA). 23 September 2010. Archived from the original on 24 September 2015.
"Call to 'suspend' diabetes drug". BBC News Online. 23 September 2010. Archived from the original on 24 September 2010.
"Drugs banned in India". Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India. Archived from the original on 21 February 2015. Retrieved 17 September 2013.
"Diabetes drug withdrawn". Stuff.co.nz. NZPA. 17 February 2011. Archived from the original on 13 October 2013. Retrieved 5 November 2011.
Harris G (19 February 2010). "Controversial Diabetes Drug Harms Heart, U.S. Concludes". The New York Times. Archived from the original on 19 March 2017.
"Updated Risk Evaluation and Mitigation Strategy (REMS)". U.S. Food and Drug Administration (FDA). 1 July 2021. Archived from the original on 6 March 2023. Retrieved 6 March 2023.
"FDA Drug Safety Communication: FDA requires removal of some prescribing and dispensing restrictions for rosiglitazone-containing diabetes medicines". U.S. Food and Drug Administration (FDA). 21 June 2019. Archived from the original on 4 September 2022. Retrieved 6 March 2023.
"Glaxo's Avandia Cleared From Sales Restrictions by FDA". Bloomberg. Archived from the original on 9 November 2014.
"FDA requires removal of certain restrictions on the diabetes drug Avandia". U.S. Food and Drug Administration (FDA) (Press release). 25 November 2013. Archived from the original on 4 May 2015.
"US agency reverses stance on controversial diabetes drug". Archived from the original on 11 December 2015.
"Glubrava EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 31 March 2020.
"Competact EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 31 March 2020.
"Pioglitazone (marketed as Actos, Actoplus Met, Duetact, and Oseni) Information". U.S. Food and Drug Administration (FDA). 11 January 2017. Archived from the original on 17 January 2021. Retrieved 31 March 2020.
"FDA Drug Safety Communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with reduced kidney function". U.S. Food and Drug Administration (FDA). 3 April 2013. Archived from the original on 25 May 2021. Retrieved 31 March 2020.
"FDA Drug Safety Communication: Updated FDA review concludes that use of type 2 diabetes medicine pioglitazone may be linked to an increased risk of bladder cancer". U.S. Food and Drug Administration (FDA). 4 August 2011. Archived from the original on 26 January 2021. Retrieved 31 March 2020.
"Janumet- sitagliptin and metformin hydrochloride tablet, film coated". DailyMed. 12 August 2019. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Janumet EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Kombiglyze XR- saxagliptin and metformin hydrochloride tablet, film coated, extended release". DailyMed. 24 October 2019. Archived from the original on 25 September 2020. Retrieved 15 May 2020.
"Komboglyze EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 30 October 2020. Retrieved 15 May 2020.
"Kazano- alogliptin and metformin hydrochloride tablet, film coated". DailyMed. 14 June 2019. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Vipdomet EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 15 May 2020.
"Jentadueto EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 9 June 2021. Retrieved 31 March 2020.
"Jentadueto- linagliptin and metformin hydrochloride tablet, film coated". DailyMed. 18 July 2019. Archived from the original on 9 June 2021. Retrieved 31 March 2020.
"Jentadueto XR- linagliptin and metformin hydrochloride tablet, film coated, extended release". DailyMed. Archived from the original on 5 October 2021. Retrieved 4 October 2021.
"Linagliptin and Metformin Hydrochloride: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 25 September 2021. Retrieved 24 September 2021.
"The Use of Medicines in the United States: Review of 2010" (PDF). Archived (PDF) from the original on 22 April 2011. (1.79 MB). IMS Institute for Healthcare Informatics (April 2011). Retrieved 28 April 2011.
"Drug Approval Package: PrandiMet (repaglinide/metformin HCI fixed-dose combination) NDA 22386". U.S. Food and Drug Administration (FDA). Archived from the original on 21 July 2020. Retrieved 21 July 2020.
"Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 22 July 2020. Retrieved 21 July 2020.
"Drug Approval Package: Qternmet XR". U.S. Food and Drug Administration (FDA). 27 January 2020. Archived from the original on 17 February 2020. Retrieved 10 June 2024.
"Qternmet XR (dapagliflozin, saxagliptin, and metformin hydrochloride) extended-release tablets, for oral use Initial U.S. Approval: 2019". DailyMed. Archived from the original on 6 March 2023. Retrieved 5 March 2023.
Sharma A (29 October 2023). "The Role of Metformin in Gastric Cancer Treatment". Witfire. Archived from the original on 3 November 2023. Retrieved 3 November 2023.
Gantois I, Popic J, Khoutorsky A, Sonenberg N (January 2019). "Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders". Annual Review of Medicine. 70: 167–181. doi:10.1146/annurev-med-081117-041238. PMID 30365357. S2CID 53093694. Archived from the original on 6 March 2023. Retrieved 9 October 2022.

webcitation.org (Global: 25^th place; English: 771^st place)

Balen A (December 2008). "Metformin therapy for the management of infertility in women with polycystic ovary syndrome" (PDF). Scientific Advisory Committee Opinion Paper 13. Royal College of Obstetricians and Gynaecologists. Archived from the original (PDF) on 18 December 2009. Retrieved 13 December 2009.

worldcat.org (Global: 4^th place; English: 4^th place)

search.worldcat.org

Strojek K, Wróbel M, Szymborska-Kajanek A, Rokicka D (2013). "Metformin — new reimbursement indications". Clinical Diabetology (in Polish). 2 (4). ISSN 2450-8187. Archived from the original on 17 September 2021.

zenodo.org (Global: 737^th place; English: 426^th place)

Werner E, Bell J (1922). "The preparation of methylguanidine, and of ββ-dimethylguanidine by the interaction of dicyandiamide, and methylammonium and dimethylammonium chlorides respectively". J. Chem. Soc., Trans. 121: 1790–95. doi:10.1039/CT9222101790. Archived from the original on 8 June 2021. Retrieved 4 September 2020.

Metformin (English Wikipedia)

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